Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| increasing hepatitis b vaccine prevalence among refugee children arriving in the united states, 2006-2012. | to determine whether the addition of hepatitis b virus (hbv) vaccine to national immunization programs improved vaccination rates among refugee children, a marginalized population with limited access to care. | 2016 | 27310356 |
| expression profile of interferon regulatory factor 1 in chronic hepatitis b virus-infected liver transplant patients. | hepatitis b virus, which mainly affects normal liver function, leads to severe acute and chronic hepatitis, resulting in cirrhosis and hepatocellular carcinoma, but can be safely treated after liver transplant. evaluation of determinative biomarkers may facilitate more effective treatment of posttransplant rejection. therefore, we investigated interferon regulatory factor 1 expression in hepatitis b virus-infected liver transplant patients with and without previous rejection compared with contro ... | 2016 | 27310137 |
| comparison of droplet digital pcr to real-time pcr for quantification of hepatitis b virus dna. | quantitative real-time pcr (qpcr) has been widely implemented for clinical hepatitis b viral load testing, but a lack of standardization and relatively poor precision hinder its usefulness. droplet digital pcr (ddpcr) is a promising tool that offers high precision and direct quantification. in this study, we compared the ddpcr qx100 platform by bio-rad with the cfx384 touch real-time pcr detection system (bio-rad, usa) to detect serial plasmid dna dilutions of known concentrations as well as hbv ... | 2016 | 27310131 |
| regulation of viral oncogenesis by micrornas. | viral infection may play a causative role in human cancers, for example hepatitis b virus (hbv) or hepatitis c virus (hcv) in liver cancer, human papilloma virus (hpv) in cervical cancer, and epstein-barr virus (ebv) in nasopharyngeal carcinoma. virally infected cells express viral-encoded genes that are critical for oncogenesis. some viruses also encode microrna (mirna) species. mirnas are small noncoding rna molecules that play an important role in cancer development and progression. recent st ... | 2014 | 27308317 |
| kinetics of serum hbsag and intrahepatic cccdna during pegylated interferon therapy in patients with hbeag-positive and hbeag-negative chronic hepatitis b. | this study was aimed at comparing clinical applicability of serum hbsag quantification in relation to intrahepatic covalently closed-circular dna (cccdna) in patients with hbeag-positive and hbeag-negative chronic hepatitis b (chb) treated with pegylated interferon (peg-ifn) monotherapy for 48 weeks. overall, 32 and 36 patients with hbeag-positive and hbeag-negative chb, respectively were recruited. paired liver biopsies at baseline and end of therapy were analyzed for cccdna. virological respon ... | 2017 | 27307409 |
| gene expression and antiviral activity of interleukin-35 in response to influenza a virus infection. | interleukin-35 (il-35) is a newly described member of the il-12 family. it has been reported to inhibit inflammation and autoimmune inflammatory disease and can increase apoptotic sensitivity. little is known about the role of il-35 during viral infection. herein, high levels of il-35 were found in peripheral blood mononuclear cells and throat swabs from patients with seasonal influenza a virus (iav) relative to healthy individuals. iav infection of human lung epithelial and primary cells increa ... | 2016 | 27307042 |
| a fast and low-cost genotyping method for hepatitis b virus based on pattern recognition in point-of-care settings. | a fast and low-cost method for hbv genotyping especially for genotypes a, b, c and d was developed and tested. a classifier was used to detect and analyze a one-step immunoassay lateral flow strip functionalized with genotype-specific monoclonal antibodies (mabs) on multiple capture lines in the form of pattern recognition for point-of-care (poc) diagnostics. the fluorescent signals from the capture lines and the background of the strip were collected via multiple optical channels in parallel. a ... | 2016 | 27306485 |
| the prognosis of hepatitis b inactive carriers in japan: a multicenter prospective study. | hepatitis b e antigen (hbeag)-negative inactive carriers, the majority of hepatitis b virus (hbv) carriers, are considered to have a good prognosis. the definition of the inactive hbv carrier state has been based on hbv dna and alanine aminotransferase (alt) levels. here we conducted a prospective study involving 18 hospitals to clarify the prognosis of hbeag-negative inactive carriers. | 2017 | 27306374 |
| prevalence of malnutrition in children with chronic hepatitis b infection. | there have been limited studies investigating the impact of chronic hepatitis b virus infection on the growth of children. | 2017 | 27305414 |
| tenofovir to prevent hepatitis b transmission in mothers with high viral load. | few data are available regarding the use of tenofovir disoproxil fumarate (tdf) during pregnancy for the prevention of mother-to-child transmission of hepatitis b virus (hbv). | 2016 | 27305192 |
| prkaa/ampk restricts hbv replication through promotion of autophagic degradation. | adenosine monophosphate-activated protein kinase (ampk) is a crucial energy sensor that maintains cellular energy homeostasis. ampk plays a critical role in macroautophagy/autophagy, and autophagy facilitates hepatitis b virus (hbv) replication. to date, the intrinsic link among ampk, autophagy and hbv production remains to be elucidated. here, we demonstrate that prkaa (a catalytic subunit of ampk) is activated in response to hbv-induced oxidative stress, which in turn decreases the production ... | 2016 | 27305174 |
| higher ratio of serum alpha-fetoprotein could predict outcomes in patients with hepatitis b virus-associated hepatocellular carcinoma and normal alanine aminotransferase. | the role of serum alpha-fetoprotein (afp) levels in the surveillance and diagnosis of hepatocellular carcinoma (hcc) is controversial. the aim of this study was to investigate the value of serially measured serum afp levels in hcc progression or recurrence after initial treatment. | 2016 | 27304617 |
| hepatitis b virus core promoter double mutations (a1762t, g1764a) are associated with lower levels of serum dihydrolipoyl dehydrogenase. | the aim of this study was to identify serum proteins with differential concentrations between hepatocellular carcinoma (hcc) patients and hbsag asymptomatic carriers among individuals infected with hepatitis b virus (hbv) with basal core promoter (bcp) double mutations (a1762t, g1764a). | 2016 | 27303803 |
| prevalence of hbsag, knowledge, and vaccination practice against viral hepatitis b infection among doctors and nurses in a secondary health care facility in lagos state, south-western nigeria. | hepatitis b virus, a highly infectious blood-borne virus poses a major threat to public health globally due to its high prevalence rate and grave consequence in causing liver cirrhosis and hepatocelullar carcinoma, the third cause of cancer death worldwide. the aim is determine the prevalence of hbsag, knowledge, and vaccination practices against viral hepatitis b infection among doctors and nurses in a health care facility. | 2016 | 27303576 |
| review article: novel therapies for hepatitis b virus cure - advances and perspectives. | current anti-viral therapies, interferon and nucleos(t)ide analogues, have been proven to reduce the progression of chronic hepatitis b (chb). however, covalently closed circular dna (cccdna) of hepatitis b virus (hbv) persists, resulting in viral relapse after the discontinuation of treatment. | 2016 | 27302653 |
| global re-wiring of p53 transcription regulation by the hepatitis b virus x protein. | the tumour suppressor p53 is a central player in transcription regulation and cell fate determination. by interacting with p53 and altering its sequence-specific binding to the response elements, the hepatitis b virus x protein (hbx) was reported to re-direct p53 regulation of some genes. | 2016 | 27302019 |
| hbv-associated intrahepatic cholangiocarcinoma with high serum alpha-fetoprotein: a case report with review of literature. | intrahepatic cholangiocarcinoma (icc) is a rare malignant tumor. the etiology of icc remains poorly understood. recently, hepatitis b virus (hbv) infection has been implicated as a potential risk factor for icc, particularly in hbv-endemic areas. elevation of serum alpha-fetoprotein (afp) is seen in approximately 20 % of icc patients. however, serum afp levels higher than 10,000 ng/ml have only been reported in a few icc patients. we report an unusual case of hbv-associated icc occurring in a ma ... | 2016 | 27301956 |
| urinary β-2 microglobulin levels sensitively altered in an osteomalacia patient receiving add-on adefovir dipivoxil therapy for hepatitis b virus infection. | adefovir dipivoxil (adv) is effective for hepatitis b virus (hbv) infection; however, adv may provoke renal injury resulting in osteomalacia, and this side effect is seldom recognized until bone fractures emerge. we herein present a 66-year-old woman with hbv infection who received adv for 6 years. although she exhibited no sign of bone fractures, her urinary β-2 microglobulin (β2mg) level increased to 83,837 μg/l and scintigraphy revealed minimal fractures of the third rib. adv was subsequently ... | 2016 | 27301512 |
| serum wfa(+) -m2bp levels for evaluation of early stages of liver fibrosis in patients with chronic hepatitis b virus infection. | accurate evaluation of liver fibrosis is crucial for predicting progression of chronic hepatitis b virus (hbv) infection. we assessed the utility of a novel fibrosis glycobiomarker wisteria floribunda agglutinin-positive mac-2-binding protein (wfa(+) -m2bp) for evaluating liver fibrosis and disease progression in patients with chronic hbv infection. | 2017 | 27300763 |
| hepatitis b virus genotypes: epidemiological and clinical relevance in asia. | hepatitis b virus (hbv) is characterized by a high genetic heterogeneity since it replicates via a reverse transcriptase that lacks proofreading ability. up to now, ten genotypes (a-j) have been described, with genotype a and d being ubiquitous but most prevalent in europe and africa, genotype b and c being confined to asia and oceania. infections with other genotypes such as e, f, g and h are also occasionally observed in asia. genotype i is rare and can be found in laos, vietnam, india and chi ... | 2016 | 27300749 |
| [thyroid dysfunction among hiv infected patients]. | thyroid dysfunction is common among patients infected with human immunodeficiency virus (hiv). it presents in different forms and has a multifactorial etiology. | 2016 | 27299819 |
| beneficial therapeutic effects of nigella sativa and/or zingiber officinale in hcv patients in egypt. | hepatitis c is a major global health burden and egypt has the highest prevalence of hepatitis c virus (hcv) worldwide. the current study was designed to evaluate the beneficial therapeutic effects of ethanolic extracts of nigella sativa, zingiber officinale and their mixture in egyptian hcv patients. sixty volunteer patients with proven hcv and fifteen age matched healthy subjects were included in this study. exclusion criteria included patients on interferon alpha (ifn-α) therapy, infection wit ... | 2013 | 27298610 |
| mir-106b promotes cancer progression in hepatitis b virus-associated hepatocellular carcinoma. | to investigate the effect of mir-106b on tumor progression in hepatitis b virus (hbv)-associated hepatocellular carcinoma (hcc). | 2016 | 27298561 |
| anti-virus prophylaxis withdrawal may be feasible in liver transplant recipients whose serum hbeag and hbv dna are negative. | anti-virus prophylactic therapy may be not necessary for the prevention of hepatitis b virus (hbv) recurrence after hbv-related liver transplantation (lt). however, studies on completely stopping the hepatitis b immune globulin (hbig) and nucleos(t)ide analogs (nuc) after lt are few. the aim of the current study was to evaluate the safety of anti-virus prophylaxis withdrawal in liver recipients whose serum hepatitis b e antigen (hbeag) and hbv dna are negative. we analyzed 190 patients undergone ... | 2016 | 27298109 |
| mannose-binding lectin 2 rs11003123 polymorphism is associated with the development of hepatocellular carcinoma in patients with hepatitis b-related cirrhosis in the chinese population. | mannose-binding lectin 2 (mbl2) plays a key role in the host immune response, but whether it is associated with hepatocellular carcinoma (hcc) is not clear. the present study aimed to identify the association between mbl2 gene polymorphisms and hcc in patients with hepatitis b virus (hbv)-related cirrhosis in the chinese population. | 2016 | 27298104 |
| plasma exchange-centered artificial liver support system in hepatitis b virus-related acute-on-chronic liver failure: a nationwide prospective multicenter study in china. | plasma exchange (pe)-centered artificial liver support system reduced the high mortality rate of hepatitis b virus (hbv)-related acute-on-chronic liver failure (aclf). but the data were diverse in different medical centers. the present prospective nationwide study was to evaluate the effects of pe on patients with hbv-aclf at different stages. | 2016 | 27298103 |
| hepatitis delta virus detected in salivary glands of sjögren's syndrome patients and recapitulates a sjögren's syndrome-like phenotype in vivo. | low-level, chronic viral infections have been suspect in the development of select autoimmune diseases, including primary sjögren's syndrome (pss). multiple studies have shown stimulation of antiviral response pathways in pss tissues suggestive of a viral infection. yet, with this data in hand, a causal link between a viral infection and development of pss had not been identified. therefore, a study was designed to further define the viral landscape within pss-affected salivary gland tissue to i ... | 2016 | 27294212 |
| infection-related focal segmental glomerulosclerosis in children. | focal segmental glomerulosclerosis (fsgs) is the most common cause of steroid resistant nephrotic syndrome in children. it describes a unique histological picture of glomerular damage resulting from several causes. in the majority of patients the causing agent is still unknown, but in some cases viral association is evident. in adults, the most established fsgs causing virus is the human immune-deficiency virus, which is related to a collapsing variant of fsgs. nevertheless, other viruses are al ... | 2016 | 27294131 |
| human leukocyte antigen-e alleles are associated with hepatitis c virus, torque teno virus, and toxoplasma co-infections but are not associated with hepatitis b virus, hepatitis d virus, and gb virus c co-infections in human immunodeficiency virus patients. | data regarding the distribution of human leukocyte antigen (hla)-e alleles and their association with blood-borne pathogen infections/co-infections are limited for many populations, including indonesia. | 2017 | 27293362 |
| prevention of hepatitis b reactivation in the setting of immunosuppression. | advances in the treatment of malignant and inflammatory diseases have developed over time, with increasing use of chemotherapeutic and immunosuppressive agents of a range of drug classes with varying mechanism and potency in their effects on the immune system. these advances have been met with the challenge of increased risk of hepatitis b virus (hbv) reactivation in susceptible individuals. the magnitude of risk of hbv reactivation is associated with the individual's hbv serological status and ... | 2016 | 27291888 |
| association of human leukocyte antigen dp/dq gene polymorphisms with chronic hepatitis b in chinese han and uygur populations. | several genome-wide association studies (gwas) have shown that human leukocyte antigen (hla) dp/dq gene polymorphisms are associated with susceptibility to chronic hepatitis b virus (hbv) infection. we clarified the roles of the hla-dp/dq gene in hbv infection in different nationalities. three single nucleotide polymorphisms (snps) in hla-dp (rs9277471, rs9277535 and rs9277542) and the snp rs9272346 in hla-dq were studied. in total, 779 patients were recruited to this study, including 400 chines ... | 2016 | 27291710 |
| effectiveness of the south african expanded program of immunization against hepatitis b in children infected with human immunodeficiency virus-1 living in a resource-limited setting of kwazulu-natal. | prevalence of human-immunodeficiency-virus/hepatitis-b-virus (hiv/hbv) coinfection and hbv vaccination response in children are unknown in kwazulu-natal. this study included 183 hiv-infected and 108 hiv-uninfected children aged between 5 and 15 years screened for hbv infection and vaccination. hbv infection occurred in 2.1% and 0% of hiv-infected and uninfected children respectively. serological response to immunization was shown in 15.8% and 61.1% of hiv-infected and uninfected children, respec ... | 2017 | 27291342 |
| apobec3de antagonizes hepatitis b virus restriction factors apobec3f and apobec3g. | the apobec3 locus consists of seven genes (a3a-a3c, a3de, a3f-a3h) that encode dna cytidine deaminases. these enzymes deaminate single-stranded dna, the result being dna peppered with cg →ta mutations preferentially in the context of 5'tpc with the exception of apobec3g (a3g), which prefers 5'cpc dinucleotides. hepatitis b virus (hbv) dna is vulnerable to genetic editing by apobec3 cytidine deaminases, a3g being a major restriction factor. apobec3de (a3de) stands out in that it is catalytically ... | 2016 | 27289067 |
| clinicopathological characteristics of non-b non-c hepatocellular carcinoma without past hepatitis b virus infection. | past hepatitis b virus (hbv) infection is considered a risk factor for hepatocarcinogenesis, but the clinicopathological characteristics of non-b non-c hepatocellular carcinoma (nbnc-hcc) excluding past hbv infection have not been investigated. this study aimed to clarify the clinicopathological features of strictly defined nbnc-hcc. | 2016 | 27288988 |
| hepatitis b virus and dna stimulation trigger a rapid innate immune response through nf-κb. | cell-intrinsic innate immunity provides a rapid first line of defense to thwart invading viral pathogens through the production of antiviral and inflammatory genes. however, the presence of many of these signaling pathways in the liver and their role in hepatitis b virus (hbv) pathogenesis is unknown. recent identification of intracellular dna-sensing pathways and involvement in numerous diverse disease processes including viral pathogenesis and carcinogenesis suggest a role for these processes ... | 2016 | 27288535 |
| polymorphisms of hla-dqb1 predict survival of hepatitis b virus-related hepatocellular carcinoma patients receiving hepatic resection. | human leukocyte antigen (hla)-dqb1 genetic polymorphisms are associated with an increased risk of hepatitis b virus-related hepatocellular carcinoma (hbv-related hcc). we aimed to evaluate the influence of genetic polymorphisms in hla-dqb1 exon region and neighboring single nucleotide polymorphisms (snps rs9275572 and rs2244546) on survival of hbv-related hcc patients undergoing hepatic resection. | 2016 | 27288300 |
| control and eradication strategies of hepatitis b virus. | hepatitis b virus (hbv) is a major human pathogen, and chronic hepatitis can lead to cirrhosis and malignant hepatocellular carcinoma. while hbv vaccine and treatment are available, it has remained a challenge to completely eradicate the virus from patients. current therapy using either interferon or polymerase inhibitors cannot cure hbv with a high efficacy. lifelong therapy is needed to suppress hbv in patients who achieve no seroconversion. here, we review recent exciting advances of new stra ... | 2016 | 27287929 |
| metabolic characterization of the natural progression of chronic hepatitis b. | worldwide, over 350 million people are chronically infected with the hepatitis b virus (hbv) and are at increased risk of developing progressive liver diseases. the confinement of hbv replication to the liver, which also acts as the central hub for metabolic and nutritional regulation, emphasizes the interlinked nature of host metabolism and the disease. still, the metabolic processes operational during the distinct clinical phases of a chronic hbv infection-immune tolerant, immune active, inact ... | 2016 | 27286979 |
| widespread hepatitis b virus genotype g (hbv-g) infection during the early years of the hiv epidemic in the netherlands among men who have sex with men. | hepatitis b virus (hbv) variants belong to different genotypes, a-j, whose worldwide distribution is linked with geography, probably because viral spread was associated with ancient human migrations. hbv genotype g (hbv-g) is an aberrant genotype with little sequence divergence, suggesting a recent origin. hbv-g is strongly associated with certain risk groups such as intravenous drug users (idus) and men who have sex with men (msm), but hardly with geography. the origin and epidemiology of hbv-g ... | 2016 | 27286832 |
| expression of oncofetal antigen glypican-3 associates significantly with poor prognosis in hbv-related hepatocellular carcinoma. | hepatocellular carcinoma (hcc) is one of the most common malignancies worldwide with poor prognosis. however, its prognostic evaluation is still an urgent problem. the objectives of this present study were to investigate oncofetal antigen glypican-3 (gpc-3) expression in hcc and their match para-cancerous tissues by the array technology with immunohistochemistry and estimate its value as a novel prognostic marker for hcc. the incidence of gpc-3 expression was 95.7 % in the cancerous tissues with ... | 2016 | 27286460 |
| hepatitis b virus genotypes, expression quantitative trait loci for znrd1-as1 and their interactions in hepatocellular carcinoma. | genetic variants in zinc ribbon domain-containing 1 antisense rna 1 (znrd1-as1) have been reported to be associated with development of hepatocellular carcinoma (hcc). we sought to determine the influences of znrd1-as1 polymorphisms and their interactions with hepatitis b virus (hbv) genotypes on the risk of hcc. in this study, we conducted a large population case-control study with 1,507 hbv-related hcc cases and 1,560 hbv persistent carriers. three single-nucleotide polymorphisms (snps) in znr ... | 2016 | 27286450 |
| comprehensive analysis of long non-coding rna expression profiles in hepatitis b virus-related hepatocellular carcinoma. | hepatocellular carcinoma (hcc) is one of the most common kinds of malignancies and is closely correlated with hepatitis b virus (hbv) infection. recent evidence has proved that long non-coding rnas (lncrnas) are implicated in development and progression of cancer. however, the contributions of lncrnas to hbv-related hcc remain largely unknown. here, we comprehensively investigated lncrna expression profiles in hbv-related hcc by annotating and analyzing microarray datasets. by analyzing 42 hcc t ... | 2016 | 27285756 |
| a potential association between exposure to hepatitis b virus and small bowel adenocarcinoma. | chronic infection with hepatitis b virus (hbv) has never been described as a risk factor for small bowel adenocarcinoma, although infection is a known risk factor for hepatocellular carcinoma. from may 2009 to december 2014, we implemented an institution-wide screening program for hepatitis b viral serologies prior to starting chemotherapy. evidence of exposure [hepatitis b core antibody (anti-hbc) positivity in the absence of hepatitis b surface antigen (hbsag) positivity] was highest in patien ... | 2016 | 27284484 |
| hbv x gene point mutations are associated with the risk of hepatocellular carcinoma: a systematic review and meta-analysis. | previous evidence suggests that the accumulation of the hepatitis b virus (hbv) x gene region point mutations may be associated with the development of hepatocellular carcinoma (hcc). however, the pathogenesis of hcc remains to be elucidated. the aim of the present meta-analysis was to investigate the association between the hbv x gene point mutations and the risk of hcc. studies were collected regarding the association between hbv x gene point mutations and the risk of hcc, which were identifie ... | 2016 | 27284442 |
| virus-associated haemophagocytic lymphohistiocytosis in a young filipino man. | haemophagocytic lymphohistiocytosis (hlh) is a rare syndrome of pathological immune activation characterised by extreme inflammation. we present a case of a young filipino man consulting for non-specific symptoms of fever, body malaise and weight loss. prominent physical examination findings included gross pallor, cachexia and hepatosplenomegaly. laboratory results revealed pancytopaenia, while bone marrow examination revealed haemophagocytosis. further workup for hlh showed hypertriglyceridaemi ... | 2016 | 27284096 |
| effects of nucleos(t)ide analogs on body composition in hbv-infected men: an age- and bmi-matched, cross-sectional study. | chronic hepatitis b (chb) requires long-term treatment with nucleos(t)ide analogs (nas). the goal of the present study was to evaluate the effects of long-term treatment with nas on body composition in men with chb. | 2017 | 27283043 |
| hepatitis b virus is associated with the clinical features and survival rate of patients with intrahepatic cholangiocarcinoma. | the pathogenesis and development of intrahepatic cholangiocarcinoma (icc) may be triggered by hepatitis b virus (hbv). we conducted this retrospective study to explore the potential association between hbv infection and the clinical features and survival rate of patients with icc. | 2016 | 27282820 |
| effect of adjuvant interferon therapy on hepatitis b virus-related hepatocellular carcinoma: a systematic review. | the objective of this study is to evaluate the efficacy of adjuvant interferon therapy for hepatitis b virus-related hepatocellular carcinoma (hcc) after different previous therapy. | 2016 | 27282382 |
| lamivudine versus entecavir for newly diagnosed hepatitis b virus-related hepatocellular carcinoma. | antiviral therapy is a key component in the management of hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc) patients. however, whether the potent drug entecavir is more effective than a less potent drug, such as lamivudine, in hbv-related hcc is not clear. | 2016 | 27282264 |
| predictive value of antiviral effects in the development of hepatocellular carcinoma in the general korean population with chronic hepatitis b. | the benefit of oral antiviral therapy in preventing hepatocellular carcinoma (hcc) in the general population is not well understood. we used a novel prediction method to estimate the risk of hcc in the korean population based on various treatment guidelines. | 2016 | 27282260 |
| rna exosome complex regulates stability of the hepatitis b virus x-mrna transcript in a non-stop-mediated (nsd) rna quality control mechanism. | hepatitis b virus (hbv) is a stealth virus, minimally inducing the interferon system required for efficient induction of both innate and adaptive immune responses. however, 90% of acutely infected adults can clear the virus, suggesting the presence of other, interferon-independent pathways leading to viral clearance. given the known ability of helicases to bind viral nucleic acids, we performed a functional screening assay to identify helicases that regulate hbv replication. we identified the su ... | 2016 | 27281821 |
| approved antiviral drugs over the past 50 years. | since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs categorized into 13 functional groups have been formally approved for the treatment of the following 9 human infectious diseases: (i) hiv infections (protease inhibitors, integrase inhibitors, entry inhibitors, nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and acyclic nucleoside phosphonate analogues), (ii) hepatitis b virus (hbv) infections (lamivudine, interferon ... | 2016 | 27281742 |
| serum progranulin levels are elevated in patients with chronic hepatitis b virus infection, reflecting viral load. | progranulin (pgrn) is implicated in infection, immunity and host defense, but its role in the pathogenesis of hbv infection remains unknown. here we investigated whether there is dysregulated production and the clinical significance of circulating pgrn in patients with chronic hbv infection. serum concentrations of pgrn were analyzed by enzyme-linked immunosorbent assay. serum pgrn levels were significantly higher in patients with chronic hbv infection than healthy subjects. pgrn levels were sig ... | 2016 | 27281451 |
| molecular evolution and phylodynamics of acute hepatitis b virus in japan. | hepatitis b virus (hbv) is prevalent worldwide and causes liver diseases, including acute and chronic hepatitis. ten hbv genotypes (a-j) with distinct geographic distributions have been reported. cases of acute hbv infection with genotype a have increased in japan nationwide since the 1990s, mainly through sexual transmission. to investigate the molecular evolution and phylodynamics of hbv genotypes, we collected acute hbv isolates acquired in japan from 1992-2002. full genomes were obtained for ... | 2016 | 27280441 |
| the prevalence of hepatitis b virus infection in nigerian children prior to vaccine introduction into the national programme on immunization schedule. | hepatitis b virus infection is a major global health problem of public health importance. in a bid to control the infection, the nigerian government in 2004 introduced hepatitis b vaccine into the national program on immunization. there are no studies on the prevalence of hepatitis b in adolescent prior to 2004. the study was aimed at determining the seroprevalence and predictors of viral hepatitis b in nigerian children aged 11-19 years. | 2016 | 27279955 |
| the safety of intracytoplasmic sperm injection in men with hepatitis b. | in this study, we aimed to evaluate the safety of using different sources of sperm when male partners were infected with hepatitis b virus (hbv). | 2016 | 27279852 |
| long-term outcomes of lung transplant recipients with hepatitis c infection: a retrospective study of the u.s. transplant registry. | chronic hepatitis c patients in need of a lung transplant are often considered ineligible due to their infection. | 2016 | 27279496 |
| extrahepatic portal vein aneurysm after orthotopic liver transplantation: a case with 9-year ultrasound observations. | we report a case of extrahepatic portal vein aneurysm (pva) in the late postoperative period after orthotopic liver transplantation (olt). a 46-year-old man underwent olt in 2001 for treatment of hepatitis b virus-induced cirrhosis and received ultrasound follow-up for 9 years. the long-term ultrasound observations showed that the diameter of the main portal vein had progressively increased from 12 mm in 2001 to 34 mm in 2007, and then remained at 34 mm from 2007 to 2010. the patient did not sho ... | 2012 | 27279116 |
| synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis c virus. | new derivatives of 2-thiobenzimidazole incorporating triazole moiety were synthesized, characterized and tested in vitro for antiviral activity against hepatitis c virus (hcv) and hepatitis b virus (hbv). their cytotoxicity was determined by the reduction in the number of viable cell. all of the synthesized compounds are inactive against hbv and some showed activity against hcv. in particular, two compounds showed significant activity, 2-{4-[(1-benzoylbenzimidazol-2-ylthio)methyl]-1h-1,2,3-triaz ... | 2016 | 27279065 |
| sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis b virus spread in mice with a humanized liver. | sodium taurocholate cotransporting polypeptide (ntcp) is a recently discovered hepatitis b virus (hbv) receptor. in the present study, we used tk-nog mice with a humanized liver to examine the impact of endogenous ntcp expression on hbv infection. upon inoculation with hbv, these mice exhibited clear viremia in 2 weeks, and serum hbv dna levels gradually increased. the frequency of hbsag-positive hepatocytes in the liver was 5.1 ± 0.6% at 2 weeks and increased with increasing hbv dna levels, rea ... | 2016 | 27278060 |
| dynamic changes in ultrasound characteristics of nodules in cirrhotic liver and their implications in surveillance for malignancy. | to investigate whether there are ultrasound characteristics that can suggest hcc in ultrasound surveillance of nodules in cirrhotic liver. | 2014 | 27277769 |
| hepatitis b and c surveillance and screening programmes in the non-eu/eea member states of the who european region: survey findings from 10 countries, 2012. | the hepatitis b virus (hbv) and hepatitis c virus (hcv) epidemics warrant a comprehensive response based on reliable population-level information about transmission, disease progression and disease burden, with national surveillance systems playing a major role. in order to shed light on the status of surveillance in countries of the world health organization (who) european region outside of the european union and european economic area (eu/eea), we surveyed 18 countries in central and eastern e ... | 2016 | 27277421 |
| hepatitis b virus surface protein-induced hpias1 transcription requires tal1, e47, myog, nfi, and mapk signal pathways. | the protein inhibitor of activated stat1 (pias1) plays important roles in regulating virus-induced chronic hepatitis, but the interaction between hepatitis b virus (hbv) and hpias1 is not clear. our aim was to verify if hbv encoding proteins enhance the transcription of hpias1 and which cis-elements and transcription factors were involved in the mechanism. in order to do, so a series of molecular biological methods, along with functional and histological studies, were performed. we found that th ... | 2016 | 27276529 |
| screening and evaluation of chronic and occult hepatitis b in chemo - radiotherapy patients with cancer. | hepatitis b virus infection (hbv) and its complications is one of the most serious problems of the health system in many parts of the world. in the present study, we will assess chronic and occult hbv and isolated anti-hepatitis b core antigen whose screening and evaluation is not routine in different populations. | 2016 | 27274500 |
| prevalence of hepatitis b virus infection in kenya, 2007. | current estimates put the prevalence of hepatitis b virus (hbv) infection in kenya at 5-8%. we determined the hbv infection prevalence in the human immunodeficiency virus (hiv)-negative kenyan adult and adolescent population based on samples collected from a national survey. we analyzed data from hiv-negative participants in the 2007 kenya aids indicator survey to estimate the hbv infection prevalence. we defined past or present hbv infection as presence of total hepatitis b core antibody (hbcab ... | 2016 | 27273644 |
| complete hepatitis b virus prophylaxis withdrawal in hepatitis b surface antigen-positive liver transplant recipients after longterm minimal immunosuppression. | tailored approaches have been attempted to prevent hepatitis b virus (hbv) reinfection in antibodies against hepatitis b surface antigen (hbsag)-positive liver transplantation (lt) recipients in order to minimize the use of hepatitis b immune globulin (hbig) and nucleoside analogues (nas). we report the results of complete hbv prophylaxis withdrawal after a follow-up of at least 6 years in lt recipients with undetectable serum hbv dna and intrahepatic total hbv dna and covalently closed circular ... | 2016 | 27272189 |
| effect of yttrium-90 radioembolization on outcomes in asian patients with early to advanced stage hepatocellular carcinoma. | the aim of this study was to investigate the effect of yttrium-90 radioembolization on the outcome of asian patients with early to advanced stage hepatocellular carcinoma (hcc). | 2016 | 27272116 |
| booster dose vaccination for preventing hepatitis b. | antibodies against hepatitis b surface antigen (hbsag) wane over time following hepatitis b immunisation; hence, it is unclear whether people vaccinated in three-dose or four-dose schedules of the hepatitis b vaccine are still immune when the hepatitis b surface antibody (anti-hbs) level in their body is undetectable, or lower than the level usually considered protective. this question may potentially be answered indirectly by measuring the anamnestic immune response to a booster dose of vaccine ... | 2016 | 27271960 |
| limited genetic diversity of hepatitis b virus in the general population of the offin river valley in ghana. | hepatitis b virus (hbv) infections account for approximately 780,000 deaths per year, most of which occur in the developing world. co-infection with hbv and hepatitis delta virus (hdv) may lead to the most severe form of viral hepatitis. in ghana, knowledge on the prevalence of hbv and hdv in the general population is scanty and the few genetic analyses of the prevailing hbv genotypes are dating back more than a decade. in the present study, 1,323 serum samples from individuals living in a rural ... | 2016 | 27271290 |
| aiming for cure in hbv and hdv infection. | chronic hepatitis b virus (hbv) infection continues to be a major health burden worldwide. currently available antiviral treatment options for chronic hepatitis b include pegylated interferon alpha2a (pegifn) or nucleos(t)ide analogues (nas). the major advantages of nas are good tolerance and potent antiviral activity associated with high rates of sustained on-treatment response to therapy. the advantages of pegifn include a finite course of treatment, the absence of drug resistance, and an oppo ... | 2016 | 27270043 |
| long-term effects of hepatitis b immunization of infants in preventing liver cancer. | the incidence of hepatocellular carcinoma (hcc) increases with age, but protective antibody responses decrease with time after infants are immunized against hepatitis b virus (hbv). we investigated whether immunization of infants against hbv prevents their developing hcc as adults. we also searched for strategies to maximize the cancer-preventive effects. | 2016 | 27269245 |
| interleukin-6-174 promoter polymorphism and susceptibility to hepatitis b virus infection as a risk factor for hepatocellular carcinoma in iran. | hepatitis b virus (hbv) is a major risk factor for hepatocellular carcinoma (hcc). cytokines play an important role in the regulation of immune responses and defense against viral infections. human interleukin 6 (il6) is a multifunctional cytokine that participates in these processes. | 2016 | 27268603 |
| time to seroconversion of hbsag to anti-hbs in individuals who lost hbsag during follow-up. | to determine the time to appearance of antibody against hepatitis b surface antigen (anti-hbs) after clearance of hepatitis b surface antigen (hbsag) in chronically infected individuals, we followed up 3963 cases with positive antibody against hepatitis b e antigen (anti-hbe) from 1991 to 2014. of these, 101 (67 males, 34 females) lost hbsag. these serocleared cases were checked every 6-month interval regarding hbsag, anti-hbs, liver function tests, and liver sonography. hepatitis b virus dna wa ... | 2016 | 27268129 |
| hiv infection, viral hepatitis and liver fibrosis among prison inmates in west africa. | prisoners represent a vulnerable population for blood-borne and sexually transmitted infections which can potentially lead to liver fibrosis and ultimately cirrhosis. however, little is known about the prevalence of liver fibrosis and associated risk factors among inmates in sub-saharan africa. | 2016 | 27267370 |
| high prevalence of hbv/a1 subgenotype in native south americans may be explained by recent economic developments in the amazon. | 2016 | 27267305 | |
| hepatitis b&c virus infection in cases of non-hodgkin's lymphoma in saudi arabia. | we followed 565 male patients with non-hodgkin's lymphoma (nhl) in two hospitals of saudi arabia. we investigated these cases for presence of hepatitis b virus (hbv) and hepatitis c virus (hcv) by determining the hbsag and anti-hcv. anti-hcv positive cases were confirmed by pcr. the nhl cases were classified on the basis of working formulation. the results of hbv and hcv in cases of nhl were compared with the prevalence of these viruses in healthy male blood donors. we found 11.2% of cases of nh ... | 2006 | 27265663 |
| downregulation of swi5 and ctc1 genes: hepatitis b virus dna polymerase transactivated protein 1-mediated inhibition of dna repair. | hepatitis b virus (hbv) dna polymerase transactivated protein 1 (hbvdnaptp1) is a novel protein upregulated by hbv dna polymerase, which has been screened by suppression subtractive hybridization technique (ssh) (genbank acc. no. ay450389). a vector pcdna3.1 (-)/myc-his a-hbvdnaptp1 was constructed and used to transfect acute monocytic leukemia cell line thp-1. hbvdnaptp1 expression was detected by western blot analysis in the cells. a cdna library of genes downregulated by hbvdnaptp1 in thp-1 c ... | 2016 | 27265469 |
| high prevalence of active and occult hepatitis b virus infections in healthcare workers from two provinces of south africa. | hepatitis b (hb) is a vaccine-preventable liver disease caused by infection with the blood-borne hepatitis b virus (hbv). south african healthcare workers (hcws) may be at high risk of occupational exposure to hbv infection, since previous studies have found suboptimal levels of protection against hbv in hcws. | 2016 | 27265453 |
| an hbv-tolerant immunocompetent model that effectively simulates chronic hepatitis b virus infection in mice. | hepatitis b virus (hbv) is the leading cause of liver disease and hepatic carcinoma (hcc). approximately 350 million people worldwide are infected with hbv and at risk of chronicity. an efficient hbv-tolerant murine model that mimics hbv infection in humans is desirable for hbv-related research. in this study, we investigated and established a murine model by hydrodynamic injection (hdi) of paav/hbv into the tail vein of aavs1 site element-transgenic mice. in 80% of the injected mice, the serum ... | 2016 | 27264142 |
| efficacy of immunization against hepatitis b virus infection in acute leukemia. | the aim of this study was to assess the antibody response to combined passive-active immunization versus active immunization against hepatitis b in 71 patients with acute leukemia with negative hepatitis b virus serology at presentation. | 2010 | 27263599 |
| seropositivity rates of hbsag, anti-hcv, anti-hiv and vdrl in blood donors in eastern turkey. | infections caused by hepatitis b virus (hbv), hepatitis c virus (hcv), and human immunodeficiency viruses (hiv) remain the leading most important health problems worldwide. screening tests such as hbsag, anti-hcv, anti-hiv and vdrl are mandatory tests to look at before transfusion of blood or blood components. in this study, donors who applied to our blood center in a nine-year period were retrospectively evaluated with respect to hbsag, anti-hcv, anti-hiv and syphilis seroprevalence. hbsag, ant ... | 2007 | 27263477 |
| development and evaluation of a double antibody sandwich elisa for the detection of human sdc-sign. | sdc-sign is the soluble form of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (dc-sign, cd209), which is a molecule involved with pathogen recognition and immune regulation. however, there is no commercially available elisa kit for detecting human sdc-sign, and the normal range of this molecule is unknown. here, we describe an elisa for detecting human sdc-sign with high specificity. first, sdc-sign protein was expressed and purified. monoclonal and polyclonal a ... | 2016 | 27262264 |
| chronic hepatitis b in children: therapeutic challenges and perspectives. | chronic hepatitis b virus (hbv) infection and hbv-related hepatitis in children remains an unmet medical need, as current treatments are only partially effective, and only in a limited number of affected children. so-called "immunotolerant" children have not shown increased serological responses to available treatments. in cases involving more active disease, serological response has only been obtained in approximately one-third of patients when using interferon, while other cases exhibited viro ... | 2017 | 27262164 |
| hepatitis b in the female population. | chronic hepatitis b infection in the female population has implications not just for the individual but for her children as well. this article discusses the natural history of hepatitis b and how it plays an important role in hepatitis b virus (hbv) transmission, the current strategies and new strategies to control hbv and reduce transmission, and the updated guidelines for the management of hbv. | 2016 | 27261904 |
| logistic regression model can reduce unnecessary artificial liver support in hepatitis b virus-associated acute-on-chronic liver failure: decision curve analysis. | several models have been proposed to predict the short-term outcome of acute-on-chronic liver failure (aclf) after treatment. we aimed to determine whether better decisions for artificial liver support system (alss) treatment could be made with a model than without, through decision curve analysis (dca). | 2016 | 27260306 |
| screening rate for hepatitis b virus infection in patients undergoing chemotherapy in japan. | the aim of this study was to investigate the screening rate for hepatitis b virus (hbv) infection, which is recommended by some guidelines for the prevention of hbv reactivation, in patients undergoing chemotherapy for malignancy in japan. | 2016 | 27260010 |
| prospective evidence of a circulating microrna signature as a non-invasive marker of hepatocellular carcinoma in hbv patients. | the predictive value of circulating micrornas (mirnas) in hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc) has been demonstrated in retrospective studies, but it has rarely been tested in prospective studies. in a cohort of 373 cancer-free hbv patients with a median follow-up of 4.5 years, we measured the expression of 24 retrospectively identified hcc-related mirnas in baseline serum samples. when we analyzed the prospective associations of mirna expression with hcc risk using the ... | 2016 | 27259992 |
| hepatitis b virus infection is a risk factor for periprosthetic joint infection among males after total knee arthroplasty: a taiwanese nationwide population-based study. | periprosthetic joint infection (pji) is a grave complication that can affect patients undergoing total knee arthroplasty (tka). in this study, we aim to determine whether hepatitis b virus (hbv) infection is a risk factor for pjis.all patients (1184 males, 3435 females) undergoing primary tka in taiwan from 2001 to 2010 were recruited for analysis.the incidence of pji was 523 among the males with hbv infection and 110 among the males without hbv (per 10,000 person-years, p < 0.001). the males wi ... | 2016 | 27258517 |
| validation of the model for end-stage liver disease score criteria in urgent liver transplantation for acute flare up of hepatitis b. | acute flare up of hepatitis b in noncirrhotic liver with rapid liver function deterioration is a critical condition. this flare up of hepatitis b may be subsided under medical treatments, otherwise urgent liver transplantation is needed. however, the necessity of urgent liver transplantation is hard to decide. in this institute, the indications of urgent liver transplantation for acute flare up of hepatitis b in noncirrhotic liver were settled according to the model for end-stage liver disease ( ... | 2016 | 27258492 |
| omission of dexamethasone from antiemetic treatment for highly emetogenic chemotherapy in breast cancer patients with hepatitis b infection or diabetes mellitus. | chemotherapy with anthracycline- and cyclophosphamide-containing regimens are classified as highly emetogenic. combinatory treatments of aprepitant (apr), palonosetron (pal), or granisetron (gra) with dexamethasone are recommended as antiemetic treatments for such emetogenic chemotherapy. we retrospectively examined whether omission of dexamethasone is tolerable for patients with hepatitis b virus (hbv) and diabetes mellitus (dm), for whom it is recommended not receive dexamethasone. | 2016 | 27258053 |
| hepatitis b reactivation during immunosuppressive therapy or cancer chemotherapy, management, and prevention: a comprehensive review-screened. | due to the close relationship between the immune system and the hepatitis b virus (hbv) replication, it is essential to monitor patients with current or past hbv infection under any type of immunosuppression. cancer chemotherapy, immunosuppressive therapies in autoimmune diseases, and immunosuppression in solid organ and stem cell transplant recipients are the major reasons for hepatitis b virus reactivation (hbvr). in this review, the challenges associated with hbvr are discussed according to t ... | 2016 | 27257429 |
| hepatitis b virus infection in the general population of iran: an updated systematic review and meta-analysis. | the hepatitis b virus (hbv) is a major global public health problem, affecting more than 2 billion people worldwide. accurate and updated data on hbv prevalence is important for further planning to control the infection. the aim of this study was to update the prevalence estimate of hbv infection in the general population of iran. | 2016 | 27257428 |
| prevalence of occult hepatitis b infection in patients visiting tertiary care hospital. | to study the prevalence of occult hepatitis b virus infection (obi) in a tertiary care hospital. | 2016 | 27257324 |
| [immunization strategy of hepatitis b vaccine among adults in china: evidence based-medicine and consideration]. | with the effective control of hepatitis b infection among children, the adults especial the young ones become the main population for new hepatitis b virus infection. now the adults receive hepatitis b vaccination voluntarily and at their own expense in china and the coverage is low. the high immunogenicity of hepatitis b vaccine has been proven among healthy adults. although the safety of hepatitis b vaccination has been documented among high-risk population such as hiv-infected people, injecti ... | 2016 | 27256724 |
| liver involvement in human immunodeficiency virus infection. | the advances in management of patients with acquired immunodeficiency syndrome (aids) with highly effective anti-retroviral therapy (haart) have resulted in increased longevity of patients with human immunodeficiency virus (hiv) infection. aids-related illnesses now account for less than 50 % of the deaths, and liver diseases have emerged as the leading cause of death in patients with hiv infection. chronic viral hepatitis, drug-related hepatotoxicity, non-alcoholic fatty liver disease, and oppo ... | 2016 | 27256434 |
| hepatitis b virus whole-x and x protein play distinct roles in hbv-related hepatocellular carcinoma progression. | the role of hbv x protein (hbx) in the development of hepatocellular carcinoma (hcc) has been well studied. however, little is known about the molecular functions of hbv whole-x protein (hbwx), a protein fused with hbx and upstream 56 amino acid, in hcc. in current study, the molecular functions of hbwx in hcc pathogenesis has been investigated, as well as comparison between hbwx and hbx. | 2016 | 27255760 |
| selection of affinity-improved neutralizing human scfv against hbv pres1 from cdr3 vh/vl mutant library. | a cdr3 mutant library was constructed from a previously isolated anti-hbv neutralizing homo sapiens scfv-31 template by random mutant primers pcr. then the library was displayed on the inner membrane surface in escherichia coli periplasmic space. seven scfv clones were isolated from the mutant library through three rounds of screening by flow cytometry. competition elisa assay indicates that isolated scfv fragments show more efficient binding ability to hbv pres1 compared with parental scfv-31. ... | 2016 | 27255707 |
| genome-wide identification of blood dna methylation patterns associated with early-onset hepatocellular carcinoma development in hepatitis b carriers. | the etiology of early-onset hepatocellular carcinoma (hcc) among hepatitis b virus (hbv) carriers remains unclear. dna methylation levels in peripheral leukocytes have been associated with different environmental exposures and immune or inflammatory response. we aimed to identify methylation signatures of peripheral leukocytes that could track hepatitis b progression to hcc, especially for early-onset hcc. we first performed an epigenome-wide association analysis on 48 matched case-control pairs ... | 2017 | 27254796 |
| molecular characterization of hepatitis b virus in blood donors from burkina faso: prevalence of quasi-subgenotype a3, genotype e, and mixed infections. | burkina faso is a highly endemic area for hepatitis b virus (hbv) which remains a major challenge for blood safety with >13% of candidate blood donors being chronically infected. however, little is known about the molecular epidemiology of the viral strains currently circulating. in this study, 99 hbv strains from hbsag positive candidate blood donors in ougadougou were genetically characterized by sequencing the pre-s/s region of the viral genome. phylogenetic analyses revealed a 25% prevalence ... | 2016 | 27253483 |
| tmem2 inhibits hepatitis b virus infection in hepg2 and hepg2.2.15 cells by activating the jak-stat signaling pathway. | we have previously observed the downregulation of tmem2 in the liver tissue of patients with chronic hepatitis b virus (hbv) infection and in hepg2.2.15 cells with hbv genomic dna. in the present study, we investigated the role and mechanism of tmem2 in hepg2 and hepg2.2.15 during hbv infection hepg2 and hepg2.2.15. hepg2 shtmem2 cells with stable tmem2 knockdown and hepg2 tmem2 and hepg2.2.15 tmem2 cells with stable tmem2 overexpression were established using lentivirus vectors. we observed red ... | 2016 | 27253403 |