Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| etiology of dna virus infections in liver transplant recipients with neonatal hepatitis. | neonatal hepatitis is a syndrome of symptoms associated with a history that includes any type of infectious, genetic, toxic, or metabolic causation. various infectious agents have been implicated in hepatic inflammation in neonates including bacterial and viral pathogens, especially dna viruses. we used molecular and antigenic methods to evaluate the role of dna viruses, such as hepatitis type b viruses (hbv), human cytomegalovirus (hcmv), herpes simplex virus (hsv), and adenovirus, in neonatal ... | 2010 | 20430185 |
| socio-demographic and behavioral correlates of herpes simplex virus type 1 and 2 infections and co-infections among adults in the usa. | although herpes simplex virus (hsv)-1 and hsv-2 may co-exist and interact, some epidemiologic features including geographical distribution, secular trends, route of transmission, and established risk factors may distinguish these hsv sub-types. with recent data indicating a link between genital herpes and either strain, a re-evaluation of risk factors for hsv-1/hsv-2 infection and co-infection is needed. | 2010 | 20418142 |
| neighbor effects of neurons bearing protective transgenes. | viral vectors bearing protective transgenes can decrease neurotoxicity after varied necrotic insults. a neuron that dies necrotically releases glutamate, calcium and reactive oxygen species, thereby potentially damaging neighboring neurons. this raises the possibility that preventing such neuron death via gene therapy can secondarily protect neighboring neurons that, themselves, do not express a protective transgene. we determined whether such "good neighbor" effects occur, by characterizing neu ... | 2010 | 20417625 |
| increased risk of hiv acquisition among kenyan men with human papillomavirus infection. | few data on the effect of human papillomavirus (hpv) infection on human immunodeficiency virus (hiv) acquisition are available. | 2010 | 20415595 |
| seroprevalence of herpes simplex virus type 2 among persons aged 14-49 years--united states, 2005-2008. | herpes simplex virus type 2 (hsv-2) is one of the most common sexually transmitted infections worldwide and the primary cause of genital and neonatal herpes and genital ulcer disease. multiple studies have shown that hsv-2 infection increases the risk for human immunodeficiency virus (hiv) infection by at least twofold. hsv-2 infection is lifelong, and serologic testing provides the best method to estimate hsv-2 prevalence. since 1976, cdc has monitored hsv-2 seroprevalence in the united states ... | 2010 | 20414188 |
| characterization of structures and antiviral effects of polysaccharides from portulaca oleracea l. | three polysaccharides including a neutral polysaccharide (rn), an acidic polysaccharide (ra) and a pectic polysaccharide (rp) were isolated from aerial part of portulaca oleracea l. and evaluated for their anti-herpes simplex virus type 2 (hsv-2) and anti-influenza a virus (ifv-a). rn was found to consist of glucose (glc), mannose (man) and arabinose (ara) with small amounts of galactose (gal), and identified to be an arabinoglucomannan. ra was mainly composed of gal and ara with a small proport ... | 2010 | 20410633 |
| apoe genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding. | apolipoprotein e is polymorphic in the human population. apoe4 has previously been reported to correlate with symptomatic oral and genital herpes disease. | 2010 | 20410080 |
| herpes infects one in six in united states. | 2010 | 20405533 | |
| seroprevalence of herpes simplex virus-2 in kidney transplant recipients: a single-center experience. | viral infections are a real threat in kidney transplant recipients because of their immunocompromised condition. this study aimed to evaluate herpes simplex virus-2 (hsv-2) seropositivity among kidney transplant recipients. | 2010 | 20404429 |
| recurrent meningitis attributable to herpes simplex virus-2 in a child. | a boy manifested episodes of recurrent meningitis that were attributed to herpes simplex virus-2 infection. he presented no concurrent or previous history of involvement of the genitourinary system. he exhibited headaches, dizziness, photophobia, loss of balance, and vomiting. he underwent three episodes of aseptic meningitis. the herpes simplex virus-2 etiology was confirmed by polymerase chain reaction of the cerebrospinal fluid in the last two episodes. after the third occurrence, he was trea ... | 2010 | 20399396 |
| anti-hsv activity of camptothecin analogues. | in order to explore the range of biological activities of the camptothecin compound class, the in vitro antiviral efficacies of series i-iv of representative members from camptothecin analogues on herpes simplex virus type 2 (hsv-2) were evaluated on vero cells. several compounds exhibited similar or better antiviral activity against hsv-2 in vitro than acyclovir. among them, compound 6 showed the highest anti-hsv-2 activity, with ic(50) values of 1.3 microg ml(-1) and si values of 27.04, respec ... | 2010 | 20397103 |
| abundant expression of hiv target cells and c-type lectin receptors in the foreskin tissue of young kenyan men. | a biological explanation for the reduction in hiv-1 (hiv) acquisition after male circumcision may be that removal of the foreskin reduces the number of target cells for hiv. the expression of potential hiv target cells and c-type lectin receptors in foreskin tissue of men at risk of hiv infection were thus analyzed. thirty-three foreskin tissue samples, stratified by herpes simplex virus type 2 status, were obtained from a randomized, controlled trial conducted in kenya. the samples were analyze ... | 2010 | 20395432 |
| male sex workers in moscow, russia: a pilot study of demographics, substance use patterns, and prevalence of hiv-1 and sexually transmitted infections. | the russian federation has been undergoing a concentrated epidemic of hiv-1 with high rates of infection among injecting drug users. less is known about the relative risk and contribution to the country's hiv epidemic by other at-risk populations including sex workers and men who have sex with men. the goals of this project were to explore demographic characteristics, substance use patterns, and estimate the prevalence of sexually transmitted infections (stis) and high-risk behaviors among male ... | 2010 | 20390488 |
| chronic viral infection and primary central nervous system malignancy. | primary central nervous system (cns) tumors cause significant morbidity and mortality in both adults and children. while some of the genetic and molecular mechanisms of neuro-oncogenesis are known, much less is known about possible epigenetic contributions to disease pathophysiology. over the last several decades, chronic viral infections have been associated with a number of human malignancies. in primary cns malignancies, two families of viruses, namely polyomavirus and herpesvirus, have been ... | 2010 | 20387126 |
| type-specific cervico-vaginal human papillomavirus infection increases risk of hiv acquisition independent of other sexually transmitted infections. | sexually transmitted infections (stis) such as herpes simplex virus (hsv)-2 are associated with an increased risk of hiv infection. human papillomavirus (hpv) is a common sti, but little is know about its role in hiv transmission. the objective of this study was to determine whether cervico-vaginal hpv infection increases the risk of hiv acquisition in women independent of other common stis. | 2010 | 20386706 |
| clinical reactivations of herpes simplex virus type 2 infection and human immunodeficiency virus disease progression markers. | the natural history of hsv-2 infection and role of hsv-2 reactivations in hiv disease progression are unclear. | 2010 | 20376310 |
| religious involvement and seroprevalence of six infectious diseases in us adults. | in the united states, religious practice is inversely associated with several chronic conditions, but no reports show whether it is inversely associated with prevalence of positive serology for infections. | 2010 | 20375957 |
| effectiveness of hiv prevention for youth in sub-saharan africa: systematic review and meta-analysis of randomized and nonrandomized trials. | systematically assess the effectiveness of hiv-prevention interventions in changing sexual behaviour of young people (10-25 years) in sub-saharan africa. | 2010 | 20375876 |
| toll-like receptor 3 immune deficiency may be causative for hsv-2-associated mollaret meningitis. | 2010 | 20375513 | |
| a rare case of absent corpus callosum with severe ventriculomegaly due to congenital herpes simplex infection. | 2010 | 20373944 | |
| [inactivated herpes simplex virus types 1 and 2 divaccine as an agent for effective immunoprophylaxis of recurrent genital herpes]. | prevention of recurrent genital herpes with the inactivated herpetic divaccine vitaherpavac against herpes simplex virus types 1 and 2 has a number of advantages over the most commonly used symptomatic therapy: it ceases or significantly reduces the number of recurrences and accordingly prolongs a relapse-free interval, abolishes viremia and the manifestations of clinical symptoms of recurrences, induces no dependence to the vaccine. coadministration of the vitaherpavac vaccine and the immunomod ... | 2010 | 20364670 |
| immunostimulating effects of a sulfated galactan from codium fragile. | a pyruvylated sulfated galactan from codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal d-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. this particular polysaccharide was found to stimulate the production of nitric oxide by inducing inos at the mrna and protein levels. in addition, the polysaccharide also induced several cytokine mrna expressions such as il ... | 2010 | 20362278 |
| new analogues of acyclovir--synthesis and biological activity. | new acyclovir esters with peptidomimetics were synthesized and evaluated in vitro for their antiviral activity against the replication of herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2). the influence of peptidomimetics containing oxazole and thiazolyl-thiazole moieties on the antiviral activity is also reported. the esters were synthesized using the coupling reagents n-ethyl-n'-(3-dimethylaminopropyl)carbodiimide hydrochloride (edc) and n,n-dimethyl-4-aminopyridine (dmap) as a catalyst. | 2010 | 20355317 |
| population level impact of an imperfect prophylactic vaccine for herpes simplex virus-2. | the continuation of developing herpes simplex virus type-2 (hsv-2) prophylactic vaccines requires parallel mathematical modeling to quantify the effect on the population of these vaccines. | 2010 | 20351622 |
| association of autism with polyomavirus infection in postmortem brains. | autism is a highly heritable behavioral disorder. yet, two decades of genetic investigation have unveiled extremely few cases that can be solely explained on the basis of de novo mutations or cytogenetic abnormalities. vertical viral transmission represents a nongenetic mechanism of disease compatible with high parent-to-offspring transmission and with low rates of disease-specific genetic abnormalities. vertically transmitted viruses should be found more frequently in the affected tissues of au ... | 2010 | 20345322 |
| [establishment of a cell model system of herpes simplex virus type ii latent infection and reactivation in sh-sy5y cells]. | to establish an experimental culture system of herpes simplex virus type ii (hsv-2) latent infection and reactivation in sh-sy5y cells. | 2010 | 20344947 |
| head and neck squamous cell carcinomas in hiv-positive patients: a preliminary investigation of viral associations. | oncogenic human papillomaviruses (hpvs) are associated with oropharyngeal squamous cell carcinoma (scc). infection with human immunodeficiency virus (hiv) increases susceptibility to opportunistic infections and viral-promoted cancers. the prevalences of hpv, herpes simplex virus (hsv), epstein-barr virus (ebv), and human herpesvirus-8 (hhv-8) have not been established for head and neck squamous cell carcinoma in hiv-positive patients (hiv+ hnscc). we have observed that hiv+ hnscc tend to contai ... | 2010 | 20333562 |
| seroprevalence of human herpes simplex, hepatitis b and epstein-barr viruses in children with acute lymphoblastic leukemia in southern iran. | to investigate the seroprevalence of herpes simplex viruses (hsv1 and hsv2), ebstein-barr virus (ebv) and hepatitis b virus (hbv) in children with acute lymphoblastic leukemia (all) in southern iran. 90 patients with all and 90 age-sex matched healthy participants were enrolled in this study. antibodies (igg) against hbsag, hsv1, hsv2, ebv different antigens including epstein-barr nuclear antigen-1 (ebna-1), viral capsid antigen (vca) and early antigen (ea) were measured by enzyme-linked immunos ... | 2010 | 20309661 |
| lipophile-conjugated sulfated oligosaccharides as novel microbicides against hiv-1. | with the aim of providing compounds suitable for further development as microbicides active against human immunodeficiency virus 1 (hiv-1) a library containing 37 lipophile-conjugated sulfated oligosaccharides was screened for antiviral and virucidal activity against this virus. four highly active compounds had low drug inhibition concentrations (ic(50)) for hiv-1 and inactivated viral particles, suggestive of virucidal properties. two of these compounds comprising a sulfated tetrasaccharide lin ... | 2010 | 20307578 |
| pathogenesis of primary acquired nasolacrimal duct obstruction. | to assess the factors assumed to be contributed in pathogenesis of primary acquired nasolacrimal duct obstruction (pando). | 2010 | 20302403 |
| loop-mediated isothermal amplification assay for the diagnosis of retinitis caused by herpes simplex virus-1. | a loop-mediated isothermal amplification (lamp) assay was developed for the detection of herpes simplex virus 1 (hsv-1). the specificity of the assay was tested using dna extracted from hsv-1-infected rabbit corneal epithelium cultures, hsv-2 grown on vero cell line, cytomegalovirus (cmv) (ad-169), varicella zoster virus (vzv) (oka-vaccine), adenovirus, aspergillus flavus and staphylococcus aureus. the specificity of lamp was confirmed by bidirectional sequencing of the amplicons. the sensitivit ... | 2011 | 20298270 |
| adherence in hiv type 1 prevention trials. | 2010 | 20235837 | |
| long-term impact of acyclovir suppressive therapy on genital and plasma hiv rna in tanzanian women: a randomized controlled trial. | herpes simplex virus (hsv) suppressive therapy reduces genital and plasma human immunodeficiency virus type 1 (hiv-1) rna over periods up to 3 months, but the long-term effect is unknown. | 2010 | 20235836 |
| selective control of type i ifn induction by the rac activator dock2 during tlr-mediated plasmacytoid dendritic cell activation. | plasmacytoid dendritic cells (pdcs) play a key role in antiviral immunity, but also contribute to the pathogenesis of certain autoimmune diseases, by producing large amounts of type i ifns. although activation of pdcs is triggered by engagement of nucleotide-sensing toll-like receptors (tlr) 7 and 9, type i ifn induction additionally requires ikappab kinase (ikk) alpha-dependent activation of ifn regulatory factor (irf) 7. however, the signaling pathway mediating ikk-alpha activation is poorly d ... | 2010 | 20231379 |
| inhibition of herpes simplex virus type 2 by vaginal lactobacilli. | the protective effect of selected vaginal lactobacillus strains (l. brevis cd2, l. salivarius fv2, l. plantarum fv9) towards herpes simplex virus type 2 (hsv-2) infection in vitro has been analyzed. living bacterial cells affect different steps of virus multiplication. the effect on the early phases of virus infection appeared related to the bacterial adhesive potential to the cell membrane while all the strains strongly reduced intracellular events of virus multiplication. the anti hsv-2 activi ... | 2009 | 20224147 |
| herpes simplex virus type 2 infection in young adult women: risk factors for infection and frequency of viral shedding. | background:: population-based studies suggest that acquisition of herpes simplex virus 2 (hsv 2) is most common between ages 20 and 29, especially in minority women. we examined hsv 2 infection and viral shedding in a cohort of young women. methods:: women, age 18 to 24 (median 21), who were part of an observational cohort enrolled between ages 14 to 17, had blood obtained for hsv 2 antibody. intensive diary collections on sexual behavior and genital symptoms and weekly vaginal swabs were obtain ... | 2010 | 20216477 |
| comparative study on the antiherpetic activity of aqueous and ethanolic extracts derived from cajanus cajan (l.) millsp. | aqueous and ethanolic extracts of cajanus cajan (fabaceae) were examined in vitro for their antiviral activity against herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2). | 2010 | 20215758 |
| viral and bacterial aetiologies of male urethritis: findings of a high prevalence of epstein-barr virus. | male urethritis is one of the most common sexually transmitted infections (stis). however, the aetiology is still unclear in many cases. in this study the prevalences of epstein-barr virus (ebv), herpes simplex virus type 1 (hsv-1), hsv-2, cytomegalovirus (cmv), adenovirus, chlamydia trachomatis, mycoplasma genitalium and ureaplasma urealyticum (including subtyping) were investigated. samples from 112 male sti attendants with microscopically verified urethritis and from a control group of 103 me ... | 2010 | 20215624 |
| population-based seroprevalence of hsv-2 and syphilis in andhra pradesh state of india. | understanding the prevalence and risk factors for common causes of ulcerative genital disease in the general population would inform current sti syndromic management and hiv testing strategies in high hiv prevalence regions of india. | 2010 | 20214795 |
| clinical and virologic efficacy of herpes simplex virus type 2 suppression by acyclovir in a multicontinent clinical trial. | acyclovir suppressive therapy (400 mg twice daily) reduces herpes simplex virus (hsv) type 2-associated genital ulcer disease and lesional hsv shedding. in an international trial of acyclovir for suppression of hsv type 2 to prevent human immunodeficiency virus (hiv) acquisition (hiv prevention trials network 039), acyclovir had a smaller effect on the frequency of genital ulcer disease as well as a smaller effect on the frequency and quantity of lesional hsv dna in african women and peruvian me ... | 2010 | 20214474 |
| phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus. | sixteen herpes simplex virus type 1 (hsv-1) and four type 2 (hsv-2) isolates resistant to acyclovir (acv) were characterized retrospectively for drug resistance. phenotypic testing was performed by means of tetrazolium reduction assay and genotypic analysis was carried out by sequencing of thymidine kinase (tk) and dna-polymerase (pol) genes. all strains were characterized as cross-resistant to penciclovir, brivudin and susceptible to cidofovir. in addition, three strains were resistant to fosca ... | 2010 | 20211650 |
| and the winner is...hiv treatment and prevention. | 2007 | 20210119 | |
| design and synthesis of 3'-fluoropenciclovir analogues as antiviral agents. | based on fluorine switch approach, a series of 3'-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and synthesized. direct reduction of beta-fluoroester to the corresponding 3-fluoroalcohol provided an easy and new entry pathway towards the synthesis of 3'-fluoropenciclovir analogues. the synthesized 3'-fluoropenciclovir analogues were evaluated for their antiviral activities against the poliovirus, hsv-1, hsv-2 and hiv. | 2010 | 20195818 |
| [study on herpes simplex virus 2 infection and risky sexual behavior among hiv-infected patients in a county of yunnan province.]. | to explore the sero-prevalence and risk factors for herpes simplex virus 2 (hsv-2) infection and unprotected sexual behavior in an ethnically diverse population of hiv-infected subjects in a county of yunnan province. | 2009 | 20193582 |
| left out but not forgotten: should closer attention be paid to coinfection with herpes simplex virus type 1 and hiv? | herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) are among the most common coinfections seen in individuals infected with hiv-1. most research on hsv-hiv coinfection has focused on hsv-2, and in particular, on its impact on hiv transmission. hsv-2 is associated with micro- and macroulcerations in genital mucosal surfaces, increased numbers of hiv target cells in genital mucosal tissue and increases in plasma hiv viral load of up to 0.5 log(10) copies/ml, such that hsv-2 infection increases ... | 2009 | 20190881 |
| numerous conserved and divergent micrornas expressed by herpes simplex viruses 1 and 2. | certain viruses use micrornas (mirnas) to regulate the expression of their own genes, host genes, or both. previous studies have identified a limited number of mirnas expressed by herpes simplex viruses 1 and 2 (hsv-1 and -2), some of which are conserved between these two viruses. to more comprehensively analyze the mirnas expressed by hsv-1 or hsv-2 during productive and latent infection, we applied a massively parallel sequencing approach. we were able to identify 16 and 17 mirnas expressed by ... | 2010 | 20181707 |
| chronic active herpes simplex type 2 encephalitis in an asymptomatic immunocompetent child. | a unique form of chronic, active, granulomatous herpes simplex type 2 encephalitis is described in an asymptomatic, immunocompetent 8-year-old girl who acquired the virus as a neonate. the extensive, bilateral cerebral parenchymal involvement was discovered incidentally. diagnosis was confirmed by a combination of serial neuroimaging, brain biopsy, and quantitative polymerase chain reaction targeted to dna sequences in the glycoprotein g gene, allowing differentiation between herpes simplex viru ... | 2010 | 20179002 |
| determinants of hiv type 1 shedding from genital ulcers among men in south africa. | our study evaluated correlates of human immunodeficiency virus (hiv)-1 lesional shedding among men with genital ulcer disease (gud). | 2010 | 20178417 |
| a highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (pi-88) exhibits virucidal activity against herpes simplex virus. | although sulfated polysaccharides potently inhibit the infectivity of herpes simplex virus (hsv) and human immunodeficiency virus in cultured cells, these compounds fail to show protective effects in humans, most likely due to their poor virucidal activity. herein we report on sulfated oligosaccharide glycosides related to muparfostat (formerly known as pi-88) and their assessment for anti-hsv activity. chemical modifications based on the introduction of specific hydrophobic groups at the reduci ... | 2010 | 20176055 |
| distinct effects of knocking down mek1 and mek2 on replication of herpes simplex virus type 2. | during infection, viruses hijack various host cell components and programs for their amplification, among which is the canonical erk signaling pathway, mainly consisting of three tiered serine/threonine kinases, raf, mek and erk. mek1 and mek2 are two isoforms of the kinase operating immediately upstream of erk, and connecting raf and erk by phosphorylating erk. previous studies have suggested that different isoforms of mek have distinct biological functions, although their in vitro kinase funct ... | 2010 | 20172001 |
| the glycoproteins c and g are equivalent target antigens for the determination of herpes simplex virus type 1-specific antibodies. | seroreactivity to the glycoproteins c and g of herpes simplex virus type 1 (hsv-1) was compared in 310 serum samples using a western blot assay containing a whole antigen extract of hsv-1 and an elisa employing gc1 isolated from hsv-1. the prevalence of reactivity to gc1 was 75.8% by western blot and 73.9% by elisa, while antibody responses to gg1 were detected in 72.9% of sera by western blot. an absolute correlation of 96.1% between the reactivity to gc1 and gg1 was demonstrated using the west ... | 2010 | 20171247 |
| in vivo requirement for atg5 in antigen presentation by dendritic cells. | autophagy is known to be important in presentation of cytosolic antigens on mhc class ii (mhc ii). however, the role of autophagic process in antigen presentation in vivo is unclear. mice with dendritic cell (dc)-conditional deletion in atg5, a key autophagy gene, showed impaired cd4(+) t cell priming after herpes simplex virus infection and succumbed to rapid disease. the most pronounced defect of atg5(-/-) dcs was the processing and presentation of phagocytosed antigens containing toll-like re ... | 2010 | 20171125 |
| recurrent vaginal shedding of herpes simplex type 2 virus in the mouse and effects of antiviral therapy. | a mouse model of recurrent herpes simplex type 2 (hsv-2) would improve our understanding of the immunobiology of recurrent disease and provide a useful model for evaluating antiviral treatments. we developed a model to evaluate recurrent vaginal hsv-2 shedding using high-dose acyclovir (acv) therapy beginning at 3 days post infection (dpi). treatment with 150mg/kg of acv for 10 days increased survival to 80% following vaginal challenge with hsv-2 strain 186 and to 100% after challenge with strai ... | 2010 | 20167236 |
| detailed characterization of t cell responses to herpes simplex virus-2 in immune seronegative persons. | in 2003, we described a small cohort of subjects (n = 6) who possessed no detectable serum abs to hsv-1 or hsv-2 and no clinical or virological evidence of mucosal hsv infection yet possessed consistently detectable hsv-specific t cell responses measured primarily by lymphoproliferative (lp) and ctl assays to whole hsv-2 ag. we termed these persons immune seronegative (is). this report characterizes the t cell responses in 22 is subjects largely recruited from studies of hsv-seronegative subject ... | 2010 | 20164419 |
| sexually transmitted diseases and anorectum. | sexually transmitted diseases (std) are a major public health problem because their incidence is increasing worldwide despite prevention campaigns and because they raise the risk of hiv infection. anorectal localisations of std are common among men who have sex with men (msm) but can also be seen among heterosexuals (men or women). transmission of such infections is due to anal sex or to other sexual behaviours like "fisting". although some pathogens (like human papillomavirus-hpv) are common in ... | 2009 | 20163035 |
| frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model. | herpes simplex virus-2 (hsv-2) is a sexually transmitted infection that is the leading cause of genital ulcers worldwide. infection is life long and is characterized by repeated asymptomatic and symptomatic shedding episodes of virus that are initiated when virus is released from neurons into the genital tract. the pattern of hsv-2 release from neurons into the genital tract is poorly understood. we fit a mathematical model of hsv-2 pathogenesis to curves generated from daily quantification of h ... | 2009 | 20161655 |
| neuroanatomic and cognitive abnormalities related to herpes simplex virus type 1 in schizophrenia. | herpes simplex virus 1 (hsv-1) tends to replicate in the temporal cortex and can damage the limbic system. the presence of serum antibodies to hsv-1 is associated with cognitive impairment in adults with schizophrenia, suggesting that cerebral gray matter abnormalities might distinguish patient subgroups defined by hsv-1 exposure. we assessed 43 adult outpatients with schizophrenia. the assessment included clinical interviews, neurocognitive testing, anatomic brain magnetic resonance imaging and ... | 2010 | 20153952 |
| treating hiv infection with drugs for hsv-2 infection? | 2010 | 20153889 | |
| daily acyclovir for hiv-1 disease progression in people dually infected with hiv-1 and herpes simplex virus type 2: a randomised placebo-controlled trial. | most people infected with hiv-1 are dually infected with herpes simplex virus type 2. daily suppression of this herpes virus reduces plasma hiv-1 concentrations, but whether it delays hiv-1 disease progression is unknown. we investigated the effect of acyclovir on hiv-1 progression. | 2010 | 20153888 |
| risk factors for herpes simplex virus type 2 and its association with hiv among pregnant teenagers in zimbabwe. | herpes simplex virus type 2 (hsv-2) causes a chronic infection that is recognised as the leading cause of genital ulcer disease worldwide and is known to increase the risk of hiv infection. in a cross-sectional study we examined risk factors for hsv-2 among 176 pregnant teenagers recruited from three primary health care clinics in zimbabwe. the prevalence of hsv-2 and hiv were 41.6% and 29.2% respectively. hiv-infected teenagers were more likely to be hsv-2 seropositive compared with the hiv uni ... | 2010 | 20152103 |
| molecular evaluation of extracellular activity of medicinal herb clinacanthus nutans against herpes simplex virus type-2. | clinacanthus nutans (burm. f.) lindau (c. nutans), a medicinal herb belonging to the family acanthaceae, has traditionally been used in herpes simplex virus (hsv) treatment in thailand. clinical trials have indicated that topical preparations produced from its extracts were effective in hsv-2 treatment. however, there is no clear evidence of the mechanism of action or a molecular target of c. nutans. in this study, the extracellular activity of c. nutans extracts against hsv-2 infected on hep-2 ... | 2010 | 20140802 |
| a qualitative study of participant adherence in a randomized controlled trial of herpes suppressive therapy for hiv prevention in tanzania. | poor participant adherence to treatment may contribute to lack of impact in some biomedical hiv prevention trials. this qualitative study explored adherence in a randomized controlled trial of herpes suppressive therapy to reduce hiv acquisition and infectivity among 1305 tanzanian women. the trial found participants completed 72% of visits on treatment; 52-56% of women on treatment had > or = 90% adherence by pill count estimate; and between six and nine months 30/86 (35%) of urine samples from ... | 2010 | 20140794 |
| public tcr use by herpes simplex virus-2-specific human cd8 ctls. | recombination of germline tcr alpha and beta genes generates polypeptide receptors for mhc peptide. ag exposure during long-term herpes simplex infections may shape the t cell repertoire over time. we investigated the cd8 t cell response to hsv-2 in chronically infected individuals by sequencing the hypervariable regions encoding tcr alpha and beta polypeptides from t cell clones recognizing virion protein 22 aa 49-57, an immunodominant epitope. the most commonly detected tcrbv gene segment, fou ... | 2010 | 20139278 |
| efficacy of continuous acyclovir infusion in neonatal herpes virus encephalitis. | we have successfully eliminated herpes simplex virus-2 from the central nervous system in a case of neonatal herpes simplex virus encephalitis with a continuous acyclovir infusion. a male infant delivered from a healthy 22-year-old woman without genital or systemic herpes symptoms around delivery began to develop fever and intractable seizures. he was started on intermittent intravenous acyclovir (20 mg/kg every 8 h) based on the diagnosis of herpes encephalitis. the virus was not eliminated wit ... | 2010 | 20135579 |
| diagnosis of neurological herpesvirus infections: real time pcr in cerebral spinal fluid analysis. | human herpesviruses (hhvs) cause many serious acute and persistent central nervous system (cns) disorders. because these infections manifest with various, often non-specific, symptoms and signs, and because specific therapy is often available, accurate diagnosis is essential. cerebrospinal fluid (csf) from 146 patients with acute meningitis or meningoencephalitis and 9 with "other neurological disorders" were analyzed by using an automatic system for nucleic acid extraction and quantitative real ... | 2009 | 20128439 |
| solvent-induced virus inactivation by acidic arginine solution. | viral clearance is a primary concern for parenteral protein biopharmaceuticals. low ph, detergent/solvent wash, or heating, called pasteurization, has been the main process for virus inactivation. detergent/solvent wash is also used to treat superficial infectious diseases, including herpes simplex virus (hsv) infections. herein we examined virus inactivation effects of acidic arginine on hsv type 2 (hsv-2) as a function of ph and temperature in an attempt to find solvent conditions that are eff ... | 2010 | 20127049 |
| causes of acute hospitalization in adolescence: burden and spectrum of hiv-related morbidity in a country with an early-onset and severe hiv epidemic: a prospective survey. | survival to older childhood with untreated, vertically acquired hiv infection, which was previously considered extremely unusual, is increasingly well described. however, the overall impact on adolescent health in settings with high hiv seroprevalence has not previously been investigated. | 2010 | 20126383 |
| low prevalence of varicella zoster virus and herpes simplex virus type 2 in saliva from human immunodeficiency virus-infected persons in the era of highly active antiretroviral therapy. | human herpesviruses, e.g., herpes simplex virus (hsv) type 1, epstein-barr virus, and cytomegalovirus, appear in saliva at greater frequency in persons infected with human immunodeficiency virus (hiv) than in healthy individuals. however, it is not known if varicella zoster virus (vzv) and hsv-2 appear simultaneously during hiv infection at greater frequency in saliva in this era of highly active antiretroviral therapy (haart). the aim of this study was to investigate the prevalence and amounts ... | 2010 | 20123407 |
| the term newborn potentially exposed to herpes simplex virus. | 2010 | 20122480 | |
| verbascoside isolated from lepechinia speciosa has inhibitory activity against hsv-1 and hsv-2 in vitro. | verbascoside has been isolated form l. speciosa after several different chromatographic methods. after its purification, the structure has been unequivocally established using modern spectroscopic techniques. as for the antiviral activity, the maximum non toxic concentration has been established and this concentration has been used in the anti herpes assay, in vitro. mechanism of action for this molecule regarding the anti-herpes activity has been studied encompassing the following assays: viruc ... | 2009 | 20120109 |
| synthesis and antiviral activity of phthiobuzone analogues. | a series of phthiobuzone analogs, prepared from potassium phthalimide or phthalandione, have been evaluated for their antiviral activities. among the candidates, compounds 5j and 5k, which contain the substituted 4-halogenated phenyl ring at n-4',4'' position, show more potent antiviral activity than phthiobuzone against herpes simplex virus 1 (ic(50)=8.56 and 2.85 microg/ml, respectively) and herpes simplex virus 2 (ic(50)=1.75 and 4.11 microg/ml, respectively). compounds 9c and 9d with a propy ... | 2010 | 20118580 |
| construction and properties of a herpes simplex virus 2 dl5-29 vaccine candidate strain encoding an hsv-1 virion host shutoff protein. | the replication-defective herpes simplex virus 2 (hsv-2) dl5-29 mutant virus strain with deletions in the u(l)5 and u(l)29 genes has been shown to protect mice and guinea pigs against challenge with wild-type (wt) hsv-2 and to protect against ocular disease caused by hsv-1 infection. the dl5-29 strain is currently being prepared for clinical trials as a herpes vaccine candidate. as a possible approach to improve the efficacy of dl5-29 as a genital herpes vaccine, we replaced the u(l)41 gene enco ... | 2010 | 20117270 |
| [seroepidemiological surveys of non vaccine-preventable diseases and their interest in public health]. | seroepidemiological surveys are epidemiological studies carried out by the use of serum tests to detect infection; they can be applied to infections in general and to vaccine-preventable diseases in particular. among other applications, seroepidemiological studies are useful for determining groups at risk for a specific disease; evaluating transmission mechanisms; and determining population groups who are critical in maintaining the transmission of infectious agents. we analysed the results of s ... | 2009 | 20111813 |
| interaction of herpes simplex virus type 2 (hsv-2) glycoprotein d with the host cell surface is sufficient to induce chlamydia trachomatis persistence. | when presented with certain unfavourable environmental conditions, chlamydia trachomatis reticulate bodies (rbs) enter into a viable, yet non-cultivable state called persistence. previously, we established an in vitro c. trachomatis and herpes simplex virus type 2 (hsv-2) co-infection model. these data indicate that (i) viral co-infection stimulates chlamydial persistence, (ii) productive hsv replication is not required for persistence induction, and (iii) hsv-induced persistence is not mediated ... | 2010 | 20110302 |
| condyloma and other infections including human immunodeficiency virus. | sexually transmitted diseases (stds) are a common public health problem and as such may be more common in a surgical practice than is believed. the recognition that a virus can be responsible for a cancer has profound significant public health implications. this article reviews the presentation and management of the more common perianal stds including human immunodeficiency virus, as well as the pathogenesis and management of anal intraepithelial neoplasia. | 2010 | 20109635 |
| postcoital bioavailability and antiviral activity of 0.5% pro 2000 gel: implications for future microbicide clinical trials. | the pharmacokinetics and pharmacodynamics of vaginal microbicides are typically assessed among sexually abstinent women. however, the physical act of sex may modulate gel distribution, and preclinical studies demonstrate seminal plasma interferes with the antiviral activity of several microbicides. this study compared the biological activity and concentration of pro 2000 in cervicovaginal lavage (cvl) collected in the absence or following coitus. | 2010 | 20107502 |
| type-specific herpes simplex virus-1 and herpes simplex virus-2 seroprevalence in romania: comparison of prevalence and risk factors in women and men. | to determine herpes simplex virus (hsv)-2 and hsv-1 seroprevalence in women and men in romania. | 2010 | 20106695 |
| hiv/std prevalence among men who have sex with men in chengdu, china and associated risk factors for hiv infection. | to assess the prevalence of hiv and selected sexually transmitted diseases (stds) among men who have sex with men (msm) in chengdu, china, and the risk factors associated with hiv infection. | 2010 | 20104114 |
| hiv-1 and stis prevalence and risk factors of miners in mining districts of yunnan, china. | to assess hiv/sexually transmitted infection (sti) prevalence and associated risk factors among miners in yunnan, china. | 2010 | 20104111 |
| acyclovir and transmission of hiv-1 from persons infected with hiv-1 and hsv-2. | most persons who are infected with human immunodeficiency virus type 1 (hiv-1) are also infected with herpes simplex virus type 2 (hsv-2), which is frequently reactivated and is associated with increased plasma and genital levels of hiv-1. therapy to suppress hsv-2 reduces the frequency of reactivation of hsv-2 as well as hiv-1 levels, suggesting that suppression of hsv-2 may reduce the risk of transmission of hiv-1. | 2010 | 20089951 |
| an evolving understanding of genital herpes pathogenesis: is it time for our approach to therapy to change as well? | 2010 | 20088692 | |
| overlapping reactivations of herpes simplex virus type 2 in the genital and perianal mucosa. | genital shedding of herpes simplex virus (hsv) type 2 occurs frequently. anatomic patterns of genital hsv-2 reactivation have not been intensively studied. | 2010 | 20088691 |
| bayesian adjustment for exposure misclassification in case-control studies. | poor measurement of explanatory variables occurs frequently in observational studies. error-prone observations may lead to biased estimation and loss of power in detecting the impact of explanatory variables on the response. we consider misclassified binary exposure in the context of case-control studies, assuming the availability of validation data to inform the magnitude of the misclassification. a bayesian adjustment to correct the misclassification is investigated. simulation studies show th ... | 2010 | 20087839 |
| a new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2. | human immunodeficiency virus type 1 (hiv-1) and herpes simplex virus type 2 (hsv-2) are responsible for 2 intersecting epidemics in which the disease caused by 1 virus facilitates the transmission of and pathogenesis by the other. therefore, suppression of one virus infection will affect the other. acyclovir, a common antiherpetic drug, was shown to directly suppress both viruses in coinfected tissues. however, both antiviral activities of acyclovir are dependent on phosphorylation by the nucleo ... | 2010 | 20085496 |
| [hsv-1 and hsv-2 seropositivity rates in pregnant women admitted to izmir ataturk research and training hospital, turkey]. | in this study, the seropositivity rates of herpes simplex virus (hsv) types 1 and 2, and their distribution according to the age groups in the sera of asymptomatic pregnant women who were admitted to gynecology and obstetrics clinics of izmir ataturk research and training hospital for routine control, were investigated. igg and igm antibodies specific for hsv-1 and hsv-2 were screened by commercial elisa kits (radim spa-pomezia, italia). total igg seropositivity rates for hsv-1 and hsv-2 were fo ... | 2009 | 20084927 |
| iron metabolism markers and haptoglobin phenotypes in susceptibility to hsv-1 or/and hsv-2 lesion relapses. | different haptoglobin (hp) phenotypes play a role in several pathologic processes including infectious diseases. in order to evaluate the role of iron storage and metabolism in susceptibility to herpetic manifestations, we studied the frequency of the hp phenotypes and iron metabolism in patients affected by h. simplex virus 1 or 2 (hsv-1 or hsv-2), compared with controls. hp phenotype and iron metabolism were determined in 100 patients with recurrent hsv-1 or hsv-2 manifestations during the rel ... | 2010 | 20084673 |
| successful increase in contraceptive uptake among kenyan hiv-1-serodiscordant couples enrolled in an hiv-1 prevention trial. | to evaluate a multipronged approach to promote dual contraceptive use by women within heterosexual hiv-1-serodiscordant partnerships. | 2009 | 20081393 |
| caspase 9 is essential for herpes simplex virus type 2-induced apoptosis in t cells. | herpes simplex virus type 2 (hsv-2) induces apoptosis in t cells by a caspase-dependent mechanism. apoptosis can occur via extrinsic (death receptor) and/or intrinsic (mitochondrial) pathways. here, we show that the initiator caspase for the intrinsic pathway is activated in t cells following hsv-2 exposure. to determine the respective contributions of intrinsic and extrinsic pathways, we assessed apoptosis in jurkat cells that are deficient in caspase 8 or fas-associating protein with death dom ... | 2010 | 20071584 |
| herpes simplex virus infections in solid organ transplant recipients. | 2009 | 20070669 | |
| estradiol limits viral replication following intravaginal immunization leading to diminished mucosal igg response and non-sterile protection against genital herpes challenge. | previously we reported that ovariectomized (ovx) mice receiving estradiol (e) prior to immunization with an attenuated strain of hsv-2 (tk-hsv-2) were not protected. lack of protection in the e group was because of the inability of tk-hsv-2 to penetrate the thick keratinized epithelium. in this study, we determined the outcome of immunization after the thickening of vaginal epithelium following e-treatment waned. ovx, c57bl/6 mice were given progesterone (p), e or saline (s) for 3 days and immun ... | 2010 | 20070285 |
| [mechanisms of chlamydia trachomatis and herpes simplex virus persistence during viral-bacterial infection]. | possible mechanisms of persistence on the example of chlamydia trachomatis in conditions of herpes simplex virus type 2 (hsv-2) superinfection in vitro and in vivo are described. emergence of persisting forms of chlamydia as well as factors influencing on this process are considered. contemporary views on pathogenesis of viral-bacterial infection with hsv-2 and c. trachomatis as well as interactions of the agents with local immunity factors are described. it was suggested that there are signalin ... | 2009 | 20066779 |
| synthesis and antiviral activity of scopadulane-rearranged diterpenes. | a new bioactive diterpene skeleton resulting from a backbone rearrangement is described. activity of the rearranged product and several derivatives against herpes virus simplex type 2 is reported. | 2010 | 20064563 |
| the prevalence, incidence and risk factors of herpes simplex virus type 2 infection among pregnant zimbabwean women followed up nine months after childbirth. | herpes simplex virus type 2 (hsv-2) is the leading cause of genital ulcer disease worldwide. the virus can be transmitted to neonates and there are scarce data regarding incidence of hsv-2 among women in pregnancy and after childbirth. the aim of this study is to measure the incidence and risk factors for hsv-2 infection in women followed for 9 months after childbirth. | 2010 | 20064273 |
| critical issues related to porcine xenograft exposure to human viruses: lessons from allotransplantation. | xenotransplantation of tissues from swine into humans poses the threat of bidirectional transfer of porcine or human microorganisms to the recipient or to the xenograft, respectively. this review focuses on recipient-derived infection. recent data are reviewed that assess the susceptibility of porcine cells to human viruses. on the basis of the experience in allotransplantation, potential consequences for the xenograft are discussed. | 2010 | 20061950 |
| simian trim5alpha proteins reduce replication of herpes simplex virus. | old world monkey trim5alpha proteins are known to block the replication of human immunodeficiency virus and other retroviruses in a species-specific fashion. in this report, we show that specific forms of simian trim5alpha proteins can restrict herpes simplex virus (hsv) infection. to define the effect of trim5alpha on hsv replication, we examined hsv infection in hela cell lines that stably express simian and human orthologs of trim5alpha proteins. we demonstrated that several simian trim5alpha ... | 2010 | 20060996 |
| effect of combinations of antiviral drugs on herpes simplex encephalitis. | 2-phenylamino-6-oxo-9-(4-hydroxybutyl)purine (hbpg) is a thymidine kinase inhibitor that prevents encephalitic death in mice caused by herpes simplex virus (hsv) types 1 and 2, although its potency is somewhat less than that of acyclovir (acv). the present study was undertaken to determine the effect of combinations of hbpg and either acv, phosphonoformate (pfa), or cidofovir (cdf) against hsv encephalitis. balb/c mice were given ocular infections with hsv-1 or hsv-2, and treated twice daily int ... | 2009 | 20054446 |
| male circumcision for the prevention of acquisition and transmission of sexually transmitted infections: the case for neonatal circumcision. | the american academy of pediatrics (aap) male circumcision policy states that while there are potential medical benefits of newborn male circumcision, the data are insufficient to recommend routine neonatal circumcision. since 2005, however, 3 randomized trials have evaluated male circumcision for prevention of sexually transmitted infections. the trials found that circumcision decreases human immunodeficiency virus acquisition by 53% to 60%, herpes simplex virus type 2 acquisition by 28% to 34% ... | 2010 | 20048246 |
| herpes simplex virus type-2 in egyptian patients with bladder cancer or cystitis. | the present study was designed to investigate the prevalence of herpes simplex virus type-2 (hsv-2) in egyptian patients with bladder cancer or cystitis and to evaluate the performance of different diagnostic hsv-2 assays. the study included 50 patients: 27 with bladder cancer (group i), 23 with cystitis (group ii) and 20 subjects as controls (group iii). hsv-2 dna was detected using polymerase chain reaction (pcr) on bladder tissue and buffy coat cells (bcc). electron microscopic studies (ems) ... | 2010 | 20041869 |
| toll-like receptor-mediated recognition of herpes simplex virus. | herpes simplex virus type 1 and 2 (hsv-1 and hsv-2, respectively) are two important human pathogens that belong to the genus simplex within the subfamily alpha of the herpesvirinae. toll-like receptors (tlrs) constitute a family of conserved sensors that play a prominent role during the early anti-viral response, including that against herpesviruses. although substantial progress has been made, central questions remain to be solved to figure out how tlrs modulate viral pathogenesis. the aim of t ... | 2010 | 20036979 |
| susceptibility to genital herpes as a biomarker predictive of increased hiv risk: expansion of a murine model of microbicide safety. | a crucial gap in the development of microbicides for hiv prevention is the absence of models predictive of safety. previous studies have demonstrated an increased susceptibility to genital herpes in mice following repeated applications of nonoxynol-9 (n-9). this study was designed to explore the underlying mechanisms, focusing on the effects that n-9 has on genital tract epithelium and to apply this expanded model to evaluate the safety of microbicides that have been advanced to clinical trials. | 2009 | 20032541 |