Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| genetic contributions to dental dimensions in brown-mantled tamarins (saguinus fuscicollis) and rhesus macaques (macaca mulatta). | the use of dental metrics in phylogenetic reconstructions of fossil primates assumes variation in tooth size is highly heritable. quantitative genetic studies in humans and baboons have estimated high heritabilities for dental traits, providing a preliminary view of the variability of dental trait heritability in nonhuman primate species. to expand upon this view, the heritabilities and evolvabilities of linear dental dimensions are estimated in brown-mantled tamarins (saguinus fuscicollis) and ... | 2019 | 30508220 |
| male-inflicted wounds have opposite effects on hair cortisol for captive male and female rhesus macaques (macaca mulatta) following new group formation. | sexual dimorphism in body size, aggression, and dispersal patterns may affect the degree to which males and females perceive aggression from either sex as stressful. whereas male macaques typically disperse to new groups at maturity, thus encountering many unfamiliar individuals of both sexes, females are philopatric, usually only encountering unfamiliar males who transfer into their natal groups. in rare circumstances, however, group fusions can expose both males and females to many novel indiv ... | 2019 | 30506293 |
| nonverbal working memory for novel images in rhesus monkeys. | human working memory is greatly facilitated by linguistic representations-for example, by verbal rehearsal and by verbal recoding of novel stimuli. the absence of language in nonhumans raises questions about the extent to which nonhuman working memory includes similar mechanisms. there is strong evidence for rehearsal-like active maintenance in working memory when monkeys are tested with highly familiar stimuli, but not when tested with novel stimuli, suggesting that working memory depends on th ... | 2018 | 30503618 |
| hiv-1 t cell epitopes targeted to rhesus macaque cd40 and dcir: a comparative study of prototype dendritic cell targeting therapeutic vaccine candidates. | hiv-1 infection can be controlled by anti-retroviral drug therapy, but this is a lifetime treatment and the virus remains latent and rapidly rebounds if therapy is stopped. hiv-1-infected individuals under this drug regimen have increased rates of cancers, cardiovascular diseases, and autoimmunity due to compromised immunity. a therapeutic vaccine boosting cellular immunity against hiv-1 is therefore desirable and, possibly combined with other immune modulating agents, could obviate the need for ... | 2018 | 30500852 |
| vitamin d3 regulates follicular development and intrafollicular vitamin d biosynthesis and signaling in the primate ovary. | there is an increasing recognition that vitamin d plays important roles in female reproduction. recent studies demonstrated that 1α,25-dihydroxyvitamin d3 (vd3), the biologically active form of vitamin d, improved ovarian follicle survival and growth in vitro. therefore, we investigated the direct effects of vd3 at the specific preantral and antral stages of follicular development, and tested the hypothesis that vitamin d receptor (vdr) and enzymes critical for vitamin d biosynthesis are express ... | 2018 | 30487754 |
| identification and functional characterization of a novel fc gamma-binding glycoprotein in rhesus cytomegalovirus. | receptors recognizing the fc part of immunoglobulin g (fcγrs) are key determinants in antibody-mediated immune responses. members of the herpesviridae interfere with this immune regulatory network by expressing viral fcγrs (vfcγrs). human cytomegalovirus (hcmv) encodes four distinct vfcγrs that differ with respect to their igg subtype specificity and their impact on antibody-mediated immune function in vitro the impact of vfcγrs on hcmv pathogenesis and immunomodulation in vivo is not known. the ... | 2019 | 30487278 |
| longitudinal mri evaluation of ischemic stroke in the basal ganglia of a rhesus macaque (macaca mulatta) with seizures. | an adult rhesus macaque developed seizures after the induction of ischemic stroke. initially, on the day of surgery, a focal ischemic lesion was present exclusively in the right caudate nucleus. by 48 h after stroke induction, the lesion had extended into the putamen, when a seizure was observed. our report highlights the temporal changes in infarction of unilateral basal ganglia after acute stroke and the accompanying clinical symptoms. this unusual case may provide additional information regar ... | 2018 | 30486918 |
| neural dynamics at successive stages of the ventral visual stream are consistent with hierarchical error signals. | ventral visual stream neural responses are dynamic, even for static image presentations. however, dynamical neural models of visual cortex are lacking as most progress has been made modeling static, time-averaged responses. here, we studied population neural dynamics during face detection across three cortical processing stages. remarkably,~30 milliseconds after the initially evoked response, we found that neurons in intermediate level areas decreased their responses to typical configurations of ... | 2018 | 30484773 |
| estrogen alters the synaptic distribution of phospho-glun2b in the dorsolateral prefrontal cortex while promoting working memory in aged rhesus monkeys. | age- and menopause-related deficits in working memory can be partially restored with estradiol replacement in women and female nonhuman primates. working memory is a cognitive function reliant on persistent firing of dorsolateral prefrontal cortex (dlpfc) neurons that requires the activation of glun2b-containing glutamate nmda receptors. we tested the hypothesis that the distribution of phospho-tyr1472-glun2b (pglun2b), a predominant form of glun2b seen at the synapse, is sensitive to aging or e ... | 2018 | 30482274 |
| coping style and cortisol levels in infancy predict hair cortisol following new group formation in captive rhesus macaques (macaca mulatta). | social instability in primate groups has been used as a model to understand how social stress affects human populations. while it is well established that individual cercopithecines have different temperaments or personalities, little is known about how temperament mediates the experience of social instability in large, naturalistic groups. here, we report findings from a study tracking a newly formed group of captive rhesus macaques (macaca mulatta). we examine whether inter-individual differen ... | 2018 | 30480316 |
| low-frequency fluctuation characteristics in rhesus macaques with siv infection: a resting-state fmri study. | simian immunodeficiency virus (siv)-infected macaque is a widely used model to study human immunodeficiency virus. the purpose of the study is to discover the amplitude of low-frequency fluctuation (alff) and fractional alff (falff) changes in siv-infected macaques. seven rhesus macaques were involved in the longitudinal mri scans: (1) baseline (healthy state); (2) siv infection stage (12 weeks after siv inoculation). alff and falff were subsequently computed and compared to ascertain the change ... | 2019 | 30478797 |
| 2d/3d cmr tissue tracking versus cmr tagging in the assessment of spontaneous t2dm rhesus monkeys with isolated diastolic dysfunction. | spontaneous t2dm in rhesus monkeys manifests as isolated diastolic dysfunction in the early stage of diabetic cardiomyopathy, similar to humans. myocardial deformation measurements have emerged as a superior way to measure left ventricular (lv) function in the early stage of cardiac dysfunction, making it possible to further evaluate early-stage lv dysfunction in spontaneous t2dm rhesus monkeys. | 2018 | 30477437 |
| a primer set for comprehensive amplification of v-genes from rhesus macaque origin based on repertoire sequencing. | recombinant antibodies serve as therapeutic molecules for a broad range of applications. high affinity antibodies are typically isolated following an active and effective immunization. human-like antibodies may be obtained from immunized nonhuman primates (nhp), such as rhesus macaque, when immunized human origin is not available. for the isolation of such antibodies, strategies like phage and yeast display, are employed. these strategies are primarily based on the amplification of the rearrange ... | 2019 | 30471299 |
| comparative analysis of expression of microbial sensing molecules in mucosal tissues with periodontal disease. | host-derived pattern recognition receptors (prrs) are necessary for effective innate immune engagement of pathogens that express microbial-associated molecular patterns (mamp) ligands for these prrs. this study used a nonhuman primate model to evaluate the expression of these sensing molecules in gingival tissues. macaca mulatta aged 12-24 with a healthy periodontium (n = 13) or periodontitis (n = 11) provided gingival tissues for assessment of naturally-occurring periodontitis. an additional gr ... | 2019 | 30470434 |
| effects of acute treatments with the serotonin 2a antagonist m100907 alone or in combination with the serotonin 2c agonist way163909 on methamphetamine self-administration in rhesus monkeys. | serotonin 5-ht2a receptor antagonists and 5-ht2c receptor agonists have been proposed as important candidates for the development of pharmacotherapies for psychostimulant abuse, with evidence suggesting that those receptors may act together to control behavior. however, the role of 5-ht2a receptors on the reinforcing effects of psychostimulant drugs has not been fully elucidated. | 2019 | 30469095 |
| virome biogeography in the lower gastrointestinal tract of rhesus macaques with chronic diarrhea. | the composition of gastrointestinal tract viromes has been associated with multiple diseases. our understanding of virus communities in the gi tract is still very limited due to challenges in sampling from different gi sites. here we defined the gi viromes of 15 rhesus macaques with chronic diarrhea. luminal content samples from terminal ileum, proximal and distal colon were collected at necropsy while samples from the rectum were collected antemortem using a fecal loop. the composition of and e ... | 2019 | 30468938 |
| methylome profiling of healthy and central precocious puberty girls. | recent studies demonstrated that changes in dna methylation (dnam) and inactivation of two imprinted genes (mkrn3 and dlk1) alter the onset of female puberty. we aimed to investigate the association of dnam profiling with the timing of human puberty analyzing the genome-wide dnam patterns of peripheral blood leukocytes from ten female patients with central precocious puberty (cpp) and 33 healthy girls (15 pre- and 18 post-pubertal). for this purpose, we performed comparisons between the groups: ... | 2018 | 30466473 |
| early t follicular helper cell responses and germinal center reactions are associated with viremia control in immunized rhesus macaques. | t follicular helper (tfh) cells are fundamental in germinal center (gc) maturation and selection of antigen-specific b cells within secondary lymphoid organs. gc-resident tfh cells have been fully characterized in human immunodeficiency virus (hiv) infection. however, the role of gc tfh cells in gc b cell responses following various simian immunodeficiency virus (siv) vaccine regimens in rhesus macaques (rms) has not been fully investigated. we characterized gc tfh cells of rms over the course o ... | 2019 | 30463978 |
| reversal and prevention of the respiratory-depressant effects of heroin by the novel μ-opioid receptor antagonist methocinnamox in rhesus monkeys. | one consequence of the ongoing opioid epidemic is a large number of overdose deaths. naloxone reverses opioid-induced respiratory depression; however, its short duration of action limits the protection it can provide. methocinnamox (mcam) is a novel opioid receptor antagonist with a long duration of action. this study examined the ability of mcam to prevent and reverse the respiratory-depressant effects (minute volume [ve]) of heroin in five monkeys. mcam (0.32 mg/kg) was given before heroin to ... | 2019 | 30463875 |
| macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brain. | the brain displays a remarkable ability to adapt following injury by altering its connections through neural plasticity. many of the biological mechanisms that underlie plasticity are known, but there is little knowledge as to when, or where in the brain plasticity will occur following injury. this knowledge could guide plasticity-promoting interventions and create a more accurate roadmap of the recovery process following injury. we causally investigated the time-course of plasticity after hippo ... | 2018 | 30462609 |
| multisensory perception of looming and receding objects in human newborns. | when newborns leave the enclosed spatial environment of the uterus and arrive in the outside world, they are faced with a new audiovisual environment of dynamic objects, actions and events both close to themselves and further away. one particular challenge concerns matching and making sense of the visual and auditory cues specifying object motion [1-5]. previous research shows that adults prioritise the integration of auditory and visual information indicating looming (for example [2]) and that ... | 2018 | 30458145 |
| cortical decoding of individual finger group motions using refit kalman filter. | objective: to date, many brain-machine interface (bmi) studies have developed decoding algorithms for neuroprostheses that provide users with precise control of upper arm reaches with some limited grasping capabilities. however, comparatively few have focused on quantifying the performance of precise finger control. here we expand upon this work by investigating online control of individual finger groups. approach: we have developed a novel training manipulandum for non-human primate (nhp) studi ... | 2018 | 30455621 |
| which male and female characteristics influence the probability of extragroup paternities in rhesus macaques, macaca mulatta? | extragroup paternity (egp) is found across a wide range of species and may entail reproductive benefits, but may also entail costs to both sexes. while population and group parameters affecting the degree of egps are relatively well established, less is known about the individual characteristics that make males and females engage in alternative reproductive tactics such as egp. applying a combination of long-term demographic and genetic data from the rhesus macaque population of cayo santiago (p ... | 2018 | 30455506 |
| effect of menstrual cycle on ethanol drinking in rhesus monkeys. | sex differences in the abuse-related effects of alcohol have been demonstrated in the clinic and in preclinical animal models. less is known about the influence of menstrual cycle phase on drinking. | 2019 | 30453105 |
| self-injurious behaviours in rhesus macaques: potential glial mechanisms. | self-injurious behaviour (sib) can be classified as intentional, direct injuring of body tissue usually without suicidal intent. in its non-suicidal form it is commonly seen as a clinical sign of borderline personality disorder, autism, ptsd, depression, and anxiety affecting a wide range of ages and conditions. in rhesus macaques sib is most commonly manifested through hair plucking, self-biting, self-hitting, and head banging. sib in the form of self-biting is observed in approximately 5-15% o ... | 2018 | 30450801 |
| effect of vasopressin v1b receptor blockade on activity of the hypothalamic-pituitary-adrenal axis in old monkeys with depression-like and anxious behavior subjected to stress or injected with vasopressin. | the effect of selective antagonist of the arginine vasopressin (avp) v1b receptors on the secretion of acth and corticosteroids in response to insulin-induced hypoglycemia and injection of avp is studied in old macaca mulatta females with depression-like and anxious behavior. intravenous antagonist in a dose of 1.1-1.7 μg/kg inhibits the increase of acth concentration, induced by hypoglycemia or injection of avp. the degree of increase in the concentrations of hydrocortisone and dehydroepiandros ... | 2018 | 30450521 |
| true homoplasy of retrotransposon insertions in primates. | how reliable are the presence/absence insertion patterns of the supposedly homoplasy-free retrotransposons, which were randomly inserted in the quasi infinite genomic space? to systematically examine this question in an up-to-date, multigenome comparison, we screened millions of primate transposed alu sine elements for incidences of homoplasious precise insertions and deletions. in genome-wide analyses, we identified and manually verified nine cases of precise parallel alu insertions of apparent ... | 2019 | 30445649 |
| early life exposure to extended general anesthesia with isoflurane and nitrous oxide reduces responsivity on a cognitive test battery in the nonhuman primate. | despite the widespread use of general anesthesia, a growing body of research suggests that anesthesia exposure early in life may be associated with acute neurotoxicity and lasting behavioral changes. to better evaluate the risk posed by early life anesthesia on cognitive development, infant rhesus monkeys were exposed to an anesthesia regimen previously shown to be neurotoxic and their cognitive development was subsequently measured using a translational operant test battery. on postnatal day 5 ... | 2019 | 30445043 |
| estimation of neural inputs and detection of saccades and smooth pursuit eye movements by sparse bayesian learning. | eye movements reveal a great wealth of information about the visual system and the brain. therefore, eye movements can serve as diagnostic markers for various neurological disorders. for an objective analysis, it is crucial to have an automatic and robust procedure to extract relevant eye movement parameters. an essential step towards this goal is to detect and separate different types of eye movements such as fixations, saccades and smooth pursuit. we have developed a model-based approach to pe ... | 2018 | 30440945 |
| specific members of the gut microbiota are reliable biomarkers of irradiation intensity and lethality in large animal models of human health. | the development of effective biomarkers for detecting the magnitude of radiation exposure and resiliency of host response is crucial to identifying appropriate treatment strategies after radiation exposure. we hypothesized that the gastrointestinal resident bacteria would demonstrate predictable, dose-dependent changes after radiation exposure across two large animal models of acute radiation syndrome. here, göttingen minipigs (gmp) (n = 50) and rhesus macaques (n = 48) were exposed to five dose ... | 2019 | 30430918 |
| treatment of female rhesus macaques with a somatostatin receptor antagonist that increases oocyte fertilization rates without affecting post-fertilization development outcomes. | to determine the effects of pgl1001, a somatostatin receptor isoform-2 (sstr-2) antagonist, on ovarian follicle development, oocyte fertilization, and subsequent embryo developmental potential in the rhesus macaque. | 2019 | 30430314 |
| optimization of preclinical metabolism for somatostatin receptor subtype 5-selective antagonists. | a series of structurally diverse azaspirodecanone and spirooxazolidinone analogues were designed and synthesized as potent and selective somatostatin receptor subtype 5 (sstr5) antagonists. four optimized compounds each representing a subseries showed improvement in their metabolic stability and pharmacokinetic profiles compared to those of the original lead compound 1 while maintaining pharmacodynamic efficacy. the optimized cyclopropyl analogue 13 demonstrated efficacy in a mouse oral glucose ... | 2018 | 30429950 |
| priming with a potent hiv-1 dna vaccine frames the quality of immune responses prior to a poxvirus and protein boost. | the use of heterologous immunization regimens and improved vector systems has led to increases in immunogenicity of hiv-1 vaccine candidates in nonhuman primates. in order to resolve interrelations between different delivery modalities, three different poxvirus boost regimens were compared. three groups of rhesus macaques were each primed with the same dna vaccine encoding gag, pol, nef, and gp140. the groups were then boosted with either the vaccinia virus strain nyvac or a variant with improve ... | 2019 | 30429343 |
| replication-competent nyvac-kc yields improved immunogenicity to hiv-1 antigens in rhesus macaques compared to nonreplicating nyvac. | as part of the continuing effort to develop an effective hiv vaccine, we generated a poxviral vaccine vector (previously described) designed to improve on the results of the rv144 phase iii clinical trial. the construct, nyvac-kc, is a replication-competent, attenuated recombinant of the vaccinia virus strain nyvac. nyvac is a vector that has been used in many previous clinical studies but is replication deficient. here, we report a side-by-side comparison of replication-restricted nyvac and rep ... | 2019 | 30429340 |
| non-synonymous genetic variants of flavin-containing monooxygenase 3 (fmo3) in cynomolgus macaques. | polymorphic human flavin-containing monooxygenase (fmo) 3 is an important drug-metabolizing enzyme for nitrogen- or sulfur-containing compounds. cynomolgus macaques, a non-human primate species widely used in drug metabolism studies, have corresponding fmo3 molecular and enzymatic similarities to humans; however, genetic polymorphisms have not been investigated in macaques. in this study, re-sequencing of fmo3 in 64 cynomolgus and 32 rhesus macaques found a total of 18 non-synonymous variants. n ... | 2019 | 30420260 |
| construction of spatiotemporal infant cortical surface atlas of rhesus macaque. | as a widely used animal model in mr imaging studies, rhesus macaque helps to better understand both normal and abnormal neural development in the human brain. however, the available adult macaque brain atlases are not well suitable for study of brain development at the early postnatal stage, since this stage undergoes dramatic changes in brain appearances and structures. building age matched atlases for this critical period is thus highly desirable yet still lacking. in this paper, we construct ... | 2018 | 30416671 |
| comparison of small-incision femtosecond laser-assisted intrastromal keratoplasty and lamellar keratoplasty in rhesus monkeys using xenogenic corneal lamellae. | in our previous study, both allogeneic and xenogeneic smallincision femtosecond laser-assisted intrastromal keratoplasty were demonstrated to be safe and effective surgeries. glycerol-dehydrated corneal lamellae could serve as alternative xenogeneic inlay grafts. however, these xenogeneic lamellae have not been explored in lamellar keratoplasty (lk). the immunoreactivity differences between corneal intrastromal xenotransplantation and xenogeneic lk have not been assessed. | 2018 | 30411683 |
| synaptic distributions of ps214-tau in rhesus monkey prefrontal cortex are associated with spine density, but not with cognitive decline. | female rhesus monkeys and women are subject to age- and menopause-related deficits in working memory, an executive function mediated by the dorsolateral prefrontal cortex (dlpfc). long-term cyclic administration of 17β-estradiol improves working memory, and restores highly plastic axospinous synapses within layer iii dlpfc of aged ovariectomized monkeys. in this study, we tested the hypothesis that synaptic distributions of tau protein phosphorylated at serine 214 (ps214-tau) are altered with ag ... | 2019 | 30408169 |
| electrical microstimulation of visual cerebral cortex elevates psychophysical detection thresholds. | sensory prostheses can restore aspects of natural sensation by delivering electrical current directly into sensory circuits. an effective sensory prosthetic should be capable of generating reliable real-time perceptual signals for hours each day over many years. however, we still know little regarding the stability of percepts produced by electrical microstimulation of cerebral sensory cortex when stimulation is delivered repeatedly over long periods. developing methods that yield highly sensiti ... | 2019 | 30406199 |
| immune protection of siv challenge by pd-1 blockade during vaccination in rhesus monkeys. | though immune correlates for protection are still under investigation, potent cytotoxic t lymphocyte responses are desirable for an ideal hiv-1 vaccine. pd-1 blockade enhances siv-specific cd8+ t cells. however, little information has been reported about how it affects the immunogenicity and protection of prophylactic siv vaccines in nonhuman primates. here, we show that pd-1 blockade during vaccination substantially improved protective efficacy in siv challenged macaques. the pd-1 pathway was b ... | 2018 | 30405615 |
| cxcr4- and ccr5-tropic hiv-1 clones are both tractable to grow in rhesus macaques. | a major issue for present hiv-1 research is to establish model systems that reflect or mimic viral replication and pathogenesis actually observed in infected humans. to this end, various strategies using macaques as infection targets have long been pursued. in particular, experimental infections of rhesus macaques by hiv-1 derivatives have been believed to be best suited, if practicable, for studies on interaction of hiv-1 and humans under various circumstances. recently, through in vitro geneti ... | 2018 | 30405570 |
| reactivation of simian varicella virus in rhesus macaques after cd4 t cell depletion. | rhesus macaques intrabronchially inoculated with simian varicella virus (svv), the counterpart of human varicella-zoster virus (vzv), developed primary infection with viremia and rash, which resolved upon clearance of viremia, followed by the establishment of latency. to assess the role of cd4 t cell immunity in reactivation, monkeys were treated with a single 50-mg/kg dose of a humanized monoclonal anti-cd4 antibody; within 1 week, circulating cd4 t cells were reduced from 40 to 60% to 5 to 30% ... | 2019 | 30404798 |
| high-throughput sequencing of putative novel micrornas in rhesus monkey peripheral blood mononuclear cells following ev71 and ca16 infection. | enterovirus 71 (ev71) and coxsackievirus a16 (ca16) remain the major pathogens in hand, foot, and mouth disease (hfmd) cases, but the mechanisms of the different pathogeneses that follow ev71 and ca16 infection remain largely unknown. | 2018 | 30404089 |
| long-lasting effects of methocinnamox on opioid self-administration in rhesus monkeys. | opioid abuse remains a serious public health challenge, despite the availability of medications that are effective in some patients (naltrexone, buprenorphine, and methadone). this study explored the potential of a pseudoirreversible mu-opioid receptor antagonist [methocinnamox (mcam)] as a treatment for opioid abuse by examining its capacity to attenuate the reinforcing effects of mu-opioid receptor agonists in rhesus monkeys. in one experiment, monkeys responded for heroin (n = 5) or cocaine ( ... | 2019 | 30401680 |
| presence of pig igg and igm in sera samples from baboons after an orthotopic liver xenotransplantation. | the immunorejection in xenotransplantation has mostly been studied from the host's immune system activation point of view and there is very little information about the graft-vs-host reaction. | 2018 | 30401409 |
| analysis of erythrocyte dynamics in rhesus macaque monkeys during infection with plasmodium cynomolgi. | malaria is a major mosquito transmitted, blood-borne parasitic disease that afflicts humans. the disease causes anaemia and other clinical complications, which can lead to death. plasmodium vivax is known for its reticulocyte host cell specificity, but many gaps in disease details remain. much less is known about the closely related species, plasmodium cynomolgi, although it is naturally acquired and causes zoonotic malaria. here, a computational model is developed based on longitudinal analyses ... | 2018 | 30400896 |
| tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines. | tafenoquine was recently approved for plasmodium vivax radical cure (krintafel™) and malaria prevention (arakoda™). | 2018 | 30400893 |
| 2-(4-methylsulfonylphenyl)pyrimidines as prospective radioligands for imaging cyclooxygenase-2 with pet-synthesis, triage, and radiolabeling. | cyclooxygenase 2 (cox-2) is an inducible enzyme responsible for the conversion of arachidonic acid into the prostaglandins, pgg2 and pgh2. expression of this enzyme increases in inflammation. therefore, the development of probes for imaging cox-2 with positron emission tomography (pet) has gained interest because they could be useful for the study of inflammation in vivo, and for aiding anti-inflammatory drug development targeting cox-2. nonetheless, effective pet radioligands are still lacking. ... | 2018 | 30400142 |
| mucosal t helper 17 and t regulatory cell homeostasis correlate with acute simian immunodeficiency virus viremia and responsiveness to antiretroviral therapy in macaques. | depletion of gut t helper 17 (th17) cells during hiv infection leads to decreased mucosal integrity and increased disease progression. conversely, t regulatory (treg) cells may inhibit antiviral responses or immune activation. in hiv elite controllers, a balanced th17/treg ratio is maintained in the blood, suggesting a role for these responses in controlling inflammation and viral replication. hiv-infected individuals exhibit a range in responsiveness to combination antiretroviral therapy (cart) ... | 2019 | 30398361 |
| stage-specific modulation of antimüllerian hormone promotes primate follicular development and oocyte maturation in the matrix-free three-dimensional culture. | to study whether follicular growth and oocyte maturation can be improved by antimüllerian hormone (amh) modulation at specific stages of follicular development. | 2018 | 30396561 |
| synthesis and in vivo evaluation of a novel pet radiotracer for imaging of synaptic vesicle glycoprotein 2a (sv2a) in nonhuman primates. | structural disruption and alterations of synapses are associated with many brain disorders including alzheimer's disease, epilepsy, depression, and schizophrenia. we have previously developed the pet radiotracer 11c-ucb-j for imaging and quantification of synaptic vesicle glycoprotein 2a (sv2a) and synaptic density in nonhuman primates and humans. here we report the synthesis of a novel radiotracer 18f-sdm-8 and its in vivo evaluation in rhesus monkeys. the in vitro binding assay of sdm-8 showed ... | 2019 | 30396272 |
| neutrophil progenitor populations of rhesus macaques. | captive-bred rhesus macaques of indian origin represent one of the most important large animal models for infectious disease, solid organ transplantation, and stem cell research. there is a dearth of information defining hematopoietic development, including neutrophil leukocyte differentiation in this species using multicolor flow cytometry. in the current study, we sought to identify cell surface markers that delineate neutrophil progenitor populations with characteristic immunophenotypes. we d ... | 2019 | 30395351 |
| homology and specificity of natural sound-encoding in human and monkey auditory cortex. | understanding homologies and differences in auditory cortical processing in human and nonhuman primates is an essential step in elucidating the neurobiology of speech and language. using fmri responses to natural sounds, we investigated the representation of multiple acoustic features in auditory cortex of awake macaques and humans. comparative analyses revealed homologous large-scale topographies not only for frequency but also for temporal and spectral modulations. in both species, posterior r ... | 2019 | 30395192 |
| development of a motor and somatosensory evoked potentials-guided spinal cord injury model in non-human primates. | background nonhuman primates (nhp) may provide the most adequate (in terms of neuroanatomy and neurophysiology) model of spinal cord injury (sci) for testing regenerative therapies, but bioethical considerations exclude their use in severe sci. new method a reproducible model of sci at the lower thoracic level has been developed in rhesus macaques. the model comprises surgical resection of 25% of the spinal cord in the projection of the dorsal funiculus and dorsolateral corticospinal pathways, c ... | 2019 | 30393204 |
| clonal expansion and compartmentalized maintenance of rhesus macaque nk cell subsets. | natural killer (nk) cells recognize and eliminate infected and malignant cells. their life histories are poorly understood, particularly in humans, due to lack of informative models and endogenous clonal markers. here, we apply transplantation of barcoded rhesus macaque hematopoietic cells to interrogate the landscape of nk cell production, expansion, and life histories at a clonal level long term and after proliferative challenge. we identify oligoclonal populations of rhesus cd56-cd16+ nk cell ... | 2018 | 30389798 |
| plasma derived exosomal biomarkers of exposure to ionizing radiation in nonhuman primates. | exposure to ionizing radiation induces a cascade of molecular events that ultimately impact endogenous metabolism. qualitative and quantitative characterization of metabolomic profiles is a pragmatic approach to studying the risks of radiation exposure since it provides a phenotypic readout. studies were conducted in irradiated nonhuman primates (nhp) to investigate metabolic changes in plasma and plasma-derived exosomes. specifically, rhesus macaques (macaca mulatta) were exposed to cobalt-60 g ... | 2018 | 30388807 |
| population genetics of the abo locus within the rhesus (macaca mulatta) and cynomolgus (m. fascicularis) macaque hybrid zone. | knowledge of the macaque abo blood group system has been critical in the development of nonhuman primates (nhps) as a translational model. serving not only as a useful homologue of the disease-linked abo system in humans, macaque abo blood groups must be typed in colonies prior to performing experimental procedures requiring blood transfusion or transplantation. while the rates of blood type incompatibility and the distributions of a, b and ab blood groups are known in large samples of rhesus (m ... | 2019 | 30387553 |
| two herpesviral noncoding pan rnas are functionally homologous but do not associate with common chromatin loci. | during lytic replication of kaposi's sarcoma-associated herpesvirus (kshv), a nuclear viral long noncoding rna known as pan rna becomes the most abundant polyadenylated transcript in the cell. knockout or knockdown of kshv pan rna results in loss of late lytic viral gene expression and, consequently, reduction of progeny virion release from the cell. here, we demonstrate that knockdown of pan rna from the related rhesus macaque rhadinovirus (rrv) phenocopies that of kshv pan rna. these two pan r ... | 2018 | 30383841 |
| lymph nodes are sites of prolonged bacterial persistence during mycobacterium tuberculosis infection in macaques. | tuberculosis is commonly considered a chronic lung disease, however, extrapulmonary infection can occur in any organ. even though lymph nodes (ln) are among the most common sites of extrapulmonary mycobacterium tuberculosis (mtb) infection, and thoracic lns are frequently infected in humans, bacterial dynamics and the effect of mtb infection in ln structure and function is relatively unstudied. we surveyed thoracic lns from mtb-infected cynomolgus and rhesus macaques analyzing pet ct scans, bact ... | 2018 | 30383808 |
| model of parafoveal chromatic and luminance temporal contrast sensitivity of humans and monkeys. | rhesus monkeys are a valuable model for studies of primate visual contrast sensitivity. their visual systems are similar to that of humans, and they can be trained to perform detection tasks at threshold during neurophysiological recording. however, the stimulus dependence of rhesus monkey contrast sensitivity has not been well characterized. temporal frequency, color, and retinal eccentricity affect the contrast sensitivity of humans in reasonably well-understood ways. to ask whether these fact ... | 2018 | 30383213 |
| effects of lorcaserin on reinstatement of responding previously maintained by cocaine or remifentanil in rhesus monkeys. | drug abuse remains a serious public health issue, underscoring the need for additional treatment options. agonists at serotonin (5-ht)2c receptors, particularly lorcaserin, are being considered as pharmacotherapies for abuse of a variety of drugs, including cocaine and opioids. the current study compared the capacity of lorcaserin to attenuate reinstatement of extinguished responding previously maintained by either cocaine or an opioid; this type of procedure is thought to model relapse, an impo ... | 2019 | 30382731 |
| dolutegravir monotherapy of simian immunodeficiency virus-infected macaques selects for several patterns of resistance mutations with variable virological outcomes. | drug resistance remains a major concern for human immunodeficiency virus (hiv) treatment. to date, very few resistance mutations have emerged in first-line combination therapy that includes the integrase strand transfer inhibitor (insti) dolutegravir (dtg). in vitro, dtg selects for several primary mutations that induce low-level dtg resistance; secondary mutations, while increasing the level of resistance, however, further impair replication fitness, which raised the idea that dtg monotherapy m ... | 2019 | 30381490 |
| a muscle-activity-dependent gain between motor cortex and emg. | whether one is delicately placing a contact lens on the surface of the eye or lifting a heavy weight from the floor, the motor system must produce a wide range of forces under different dynamical loads. how does the motor cortex, with neurons that have a limited activity range, function effectively under these widely varying conditions? in this study, we explored the interaction of activity in primary motor cortex (m1) and muscles (electromyograms, emgs) of two male rhesus monkeys for wrist move ... | 2019 | 30379603 |
| visual preferences for direct-gaze faces in infant macaques (macaca mulatta) with limited face exposure. | from birth, human and nonhuman primates attend more to faces with direct gaze compared with averted gaze, and previous studies report that attention to the eyes is linked to the emergence of later social skills. here, we explored whether early experiences influence attraction to eye contact in infant macaques by examining their attention to face pairs varying in their gaze direction across the first 13 weeks of life. infants raised by human caretakers had limited conspecific interactions (nurser ... | 2019 | 30378109 |
| hepatitis b vaccination using a dissolvable microneedle patch is immunogenic in mice and rhesus macaques. | chronic hepatitis b virus infection remains a major global public health problem, accounting for about 887,000 deaths in 2015. perinatal and early childhood infections are strongly associated with developing chronic hepatitis b. adding a birth dose of the hepatitis b vaccine (hepb bd) to routine childhood vaccination can prevent over 85% of these infections. however, hepb bd coverage remains low in many global regions, with shortages of birth attendants trained to vaccinate and limited hepb bd s ... | 2018 | 30377659 |
| immune priming and long-term persistence of memory b cells after inactivated poliovirus vaccine in macaque models: support for at least 2 doses. | as a risk-mitigation strategy to minimize paralytic polio following withdrawal of sabin type 2 from the oral poliovirus vaccine in april 2016, a single full dose or 2 fractional doses of inactivated poliovirus vaccine (ipv) are recommended. however, limited knowledge exists on long-term persistence of immune memory following 1- or 2-dose ipv schedules. | 2018 | 30376091 |
| two case reports of unusual phimosis in rhesus monkeys (macaca mulatta). | phimosis is the inability of the penis to protrude from the prepuce. in the present report, we present two cases of phimosis in two rhesus monkeys. surgical enlargement of preputial orifice was performed for unrestricted movement of penis. the exact cause of this condition is unknown to us. | 2019 | 30375654 |
| static magnetic fields reduce epileptiform activity in anesthetized rat and monkey. | increasing evidence indicates that static magnetic fields (smf) reduce cortical activity in both human and animal models. the aim of this work was to investigate the effect of smf on epileptiform cortical activity, a condition related to an abnormal increase in neuronal excitability. the first experimental block included a pilocarpine rat model of epilepsy, in which a magnetic neodymium nickel-plated cylinder, a magnetic field of 0.5 t, or "sham" were placed over the skull. in the second experim ... | 2018 | 30375430 |
| implicit preference for human trustworthy faces in macaque monkeys. | it has been shown that human judgements of trustworthiness are based on subtle processing of specific facial features. however, it is not known if this ability is a specifically human function, or whether it is shared among primates. here we report that macaque monkeys (macaca mulatta and macaca fascicularis), like humans, display a preferential attention to trustworthiness-associated facial cues in computer-generated human faces. monkeys looked significantly longer at faces categorized a priori ... | 2018 | 30375399 |
| freestanding bipedal posture and coordinated bimanual manipulation significantly influence lateralized hand use in rhesus monkeys (macaca mulatta) and chimpanzees (pan troglodytes). | investigations of behavioral lateralization in nonhuman primates yield important insights into brain-behavior relationships. in turn, they provide clues about both proximal and distal factors that shape the development and expression of association between motor asymmetries and underlying neural substrates. nonhuman primates afford unique comparative opportunities to evaluate potential routes for the evolution of handedness, as well as to uncover relationships between behavioral lateralization a ... | 2019 | 30372106 |
| rates of human-macaque interactions affect grooming behavior among urban-dwelling rhesus macaques (macaca mulatta). | the impact of anthropogenic environmental changes may impose strong pressures on the behavioral flexibility of free-ranging animals. here, we examine whether rates of interactions with humans had both a direct and indirect influence on the duration and distribution of social grooming in commensal rhesus macaques (macaca mulatta). | 2019 | 30368773 |
| microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. | although thimerosal, an ethylmercury-based preservative, has been removed from most pediatric vaccines in the united states, some multidose vaccines, such as influenza vaccines, still contain thimerosal. considering that a growing number of studies indicate involvement of the gut microbiome in infant immune development and vaccine responses, it is important to elucidate the impact of pediatric vaccines, including thimerosal-containing vaccines, on gut microbial structure and function. here, a no ... | 2018 | 30367140 |
| evidence for persistence of the shiv reservoir early after mhc haploidentical hematopoietic stem cell transplantation. | allogeneic transplantation (allo-hct) has led to the cure of hiv in one individual, raising the question of whether transplantation can eradicate the hiv reservoir. to test this, we here present a model of allo-hct in shiv-infected, cart-suppressed nonhuman primates. we infect rhesus macaques with shiv-1157ipd3n4, suppress them with cart, then transplant them using mhc-haploidentical allogeneic donors during continuous cart. transplant results in ~100% myeloid donor chimerism, and up to 100% t-c ... | 2018 | 30361514 |
| siv/shiv-zika co-infection does not alter disease pathogenesis in adult non-pregnant rhesus macaque model. | due to the large geographical overlap of populations exposed to zika virus (zikv) and human immunodeficiency virus (hiv), understanding the disease pathogenesis of co-infection is urgently needed. this warrants the development of an animal model for hiv-zikv co-infection. in this study, we used adult non-pregnant macaques that were chronically infected with simian immunodeficiency virus/chimeric simian human immunodeficiency virus (siv/shiv) and then inoculated with zikv. plasma viral loads of b ... | 2018 | 30359380 |
| neonatal hippocampal lesions facilitate biconditional contextual discrimination learning in monkeys. | this study examined whether selective neonatal hippocampal lesions in monkeys (macaca mulatta), which left the surrounding cortical areas (parahippocampal cortex) intact, affect contextual learning and memory compared with controls. monkeys were tested with an automated touch-screen apparatus so that stimuli and contextual cues could be manipulated independently of one another. the data suggest that animals with neonatal hippocampal lesions have sparing of function with regard to contextual lear ... | 2018 | 30359064 |
| donor spermatogenesis in de novo formed seminiferous tubules from transplanted testicular cells in rhesus monkey testis. | can transplanted primate testicular cells form seminiferous tubules de novo, supporting complete spermatogenesis? | 2018 | 30358843 |
| perfusion of the placenta assessed using arterial spin labeling and ferumoxytol dynamic contrast enhanced magnetic resonance imaging in the rhesus macaque. | to investigate the correspondence between arterial spin labeling (asl) flow-sensitive alternating inversion recovery (fair) and ferumoxytol dce mri for the assessment of placental intervillous perfusion. | 2019 | 30357902 |
| molecular analysis of two different mrsa clones st188 and st3268 from primates (macaca spp.) in a united states primate center. | methicillin-resistant staphylococcus aureus (mrsa) were identified in macaques, their environmental facility, and nasal cultures of personnel from the washington national primate research center [wanprc] and included mrsa st188 sccmec iv and mrsa st3268 sccmec v. the aim of the current study was to determine the carriage of virulence genes, antibiotic resistance genes, and other characteristics of the primate mrsa isolates to determine if there were any obvious differences that would account for ... | 2018 | 30356855 |
| natural history of postnatal rhesus cytomegalovirus shedding by dams and acquisition by infant rhesus monkeys. | human infants frequently acquire human cytomegalovirus (hcmv) through breastfeeding, resulting in persistent high-level viral shedding in saliva and urine and infectivity to others, including pregnant women. thus, vaccination to interrupt postnatal hcmv transmission is an attractive strategy to prevent hcmv spread and congenital infection. rhesus cmv (rhcmv) in nonhuman primates is a valuable model for the study of immune strategies to prevent cmv transmission. although rhesus monkeys typically ... | 2018 | 30356332 |
| encoding of reward and decoding movement from the frontal eye field during smooth pursuit eye movements. | expectation of reward potentiates sensorimotor transformations to drive vigorous movements. one of the main challenges in studying reward is to determine how representations of reward interact with the computations that drive behavior. we recorded activity in smooth pursuit neurons in the frontal eye field (fef) of two male rhesus monkeys while controlling the eye speed by manipulating either reward size or target speed. the neurons encoded the different reward conditions more strongly than the ... | 2018 | 30355635 |
| selective loss of thin spines in area 7a of the primate intraparietal sulcus predicts age-related working memory impairment. | brodmann area 7a of the parietal cortex is active during working memory tasks in humans and nonhuman primates, but the composition and density of dendritic spines in area 7a and their relevance both to working memory and cognitive aging remain unexplored. aged monkeys have impaired working memory, and we have previously shown that this age-induced cognitive impairment is partially mediated by a loss of thin spines in prefrontal cortex area 46, a critical area for working memory. because area 46 ... | 2018 | 30355632 |
| functional mri in macaque monkeys during task switching. | nonhuman primates have proven to be a valuable animal model for exploring neuronal mechanisms of cognitive control. one important aspect of executive control is the ability to switch from one task to another, and task-switching paradigms have often been used in human volunteers to uncover the underlying neuronal processes. to date, however, no study has investigated task-switching paradigms in nonhuman primates during functional magnetic resonance imaging (fmri). we trained two rhesus macaques t ... | 2018 | 30355629 |
| diversity of macaque microbiota compared to the human counterparts. | studies on the microbial communities in non-human primate hosts provide unique insights in both evolution and function of microbes related to human health and diseases. using 16s rrna gene amplicon profiling, we examined the oral, anal and vaginal microbiota in a group of non-captive rhesus macaques (n = 116) and compared the compositions with the healthy communities from human microbiome project. the macaque microbiota was dominated by bacteroidetes, firmicutes and proteobacteria; however, ther ... | 2018 | 30349024 |
| bridging the species gap in translational research for neurodevelopmental disorders. | the prevalence and societal impact of neurodevelopmental disorders (ndds) continue to increase despite years of research in both patient populations and animal models. there remains an urgent need for translational efforts between clinical and preclinical research to (i) identify and evaluate putative causes of ndd, (ii) determine their underlying neurobiological mechanisms, (iii) develop and test novel therapeutic approaches, and (iv) translate basic research into safe and effective clinical pr ... | 2019 | 30347236 |
| impact of dengue virus serotype 2 strain diversity on serological immune responses to dengue. | dengue is a mosquito-borne disease caused by four dengue virus serotypes (denv1-4) that are loosely categorized by sequence commonalities and antibody recognition profiles. the highly variable envelope protein (e) that is prominently displayed on the surface of denv is an essential component of vaccines currently under development, yet the impact of using single strains to represent each serotype in tetravalent vaccines has not been adequately studied. we synthesized chimeric e by replacing high ... | 2018 | 30347144 |
| antiretroviral concentrations and surrogate measures of efficacy in the brain tissue and csf of preclinical species. | 1. antiretroviral concentrations in cerebrospinal fluid (csf) are used as surrogate for brain tissue, although sparse data support this. we quantified antiretrovirals in brain tissue across preclinical models, compared them to csf, and calculated 90% inhibitory quotients (iq90) for nonhuman primate (nhp) brain tissue. spatial distribution of efavirenz was performed by mass-spectrometry imaging (msi). 2. hiv or rt-shiv-infected and uninfected animals from two humanized mouse models (hemopoietic-s ... | 2019 | 30346892 |
| comment on " in vivo [18f]ge-179 brain signal does not show nmda-specific modulation with drug challenges in rodents and nonhuman primates". | schoenberger and colleagues ( schoenberger et al. ( 2018 ) acs chem. neurosci. 9 , 298 - 305 ) recently reported attempts to demonstrate specific binding of the positron emission tomography (pet) radiotracer, [18f]ge-179, to nmda receptors in both rats and rhesus macaques. ge-179 did not work as expected in animal models; however, we disagree with the authors' conclusion that "the [18f]ge-179 signal seems to be largely nonspecific". it is extremely challenging to demonstrate specific binding for ... | 2019 | 30346706 |
| entrainment and maintenance of an internal metronome in supplementary motor area. | to prepare timely motor actions, we constantly predict future events. regularly repeating events are often perceived as a rhythm to which we can readily synchronize our movements, just as in dancing to music. however, the neuronal mechanisms underlying the capacity to encode and maintain rhythms are not understood. we trained nonhuman primates to maintain the rhythm of a visual metronome of diverse tempos and recorded neural activity in the supplementary motor area (sma). sma exhibited rhythmic ... | 2018 | 30346275 |
| a comparative analysis of gut microbiota disturbances in the gottingen minipig and rhesus macaque models of acute radiation syndrome following bioequivalent radiation exposures. | in rodent studies, the gut microbiota has been implicated in facilitating both radioresistance, by protecting the epithelium from apoptotic responses and radiosensitivity, inducing endothelial apoptotic responses. despite the observation that large animal models, such as the chinese rhesus macaque and the gottingen minipig, demonstrate similarity to human physiologic responses to radiation, little is known about radiation-induced changes of the gut microbiome in these models. to compare the two ... | 2018 | 30343431 |
| social stability influences the association between adrenal responsiveness and hair cortisol concentrations in rhesus macaques. | hair cortisol concentrations are increasingly being used in both humans and nonhuman animals as a biomarker of chronic stress. however, many details regarding how hair cortisol concentrations relate to the dynamic activity and regulation of the hpa axis are still unknown. the current study explores 1) how the regulation of the hpa axis in infancy relates to hair cortisol concentrations (hcc) in infancy 2) whether this relationship persists into adulthood under conditions of social stability, and ... | 2019 | 30342315 |
| preconditioning in the rhesus macaque induces a proteomic signature following cerebral ischemia that is associated with neuroprotection. | each year, thousands of patients are at risk of cerebral ischemic injury, due to iatrogenic responses to surgical procedures. prophylactic treatment of these patients as standard care could minimize potential neurological complications. we have shown that protection of brain tissue, in a non-human primate model of cerebral ischemic injury, is possible through pharmacological preconditioning using the immune activator d192935. we postulate that preconditioning with d192935 results in neuroprotect ... | 2019 | 30341719 |
| modeling large fluctuations of thousands of clones during hematopoiesis: the role of stem cell self-renewal and bursty progenitor dynamics in rhesus macaque. | in a recent clone-tracking experiment, millions of uniquely tagged hematopoietic stem cells (hscs) and progenitor cells were autologously transplanted into rhesus macaques and peripheral blood containing thousands of tags were sampled and sequenced over 14 years to quantify the abundance of hundreds to thousands of tags or "clones." two major puzzles of the data have been observed: consistent differences and massive temporal fluctuations of clone populations. the large sample-to-sample variabili ... | 2018 | 30335762 |
| acute infection and subsequent subclinical reactivation of herpes simplex virus 2 after vaginal inoculation of rhesus macaques. | herpes simplex virus 2 (hsv-2) is a common sexually transmitted infection with a highly variable clinical course. many infections quickly become subclinical, with episodes of spontaneous virus reactivation. to study host-hsv-2 interactions, an animal model of subclinical hsv-2 infection is needed. in an effort to develop a relevant model, rhesus macaques (rm) were inoculated intravaginally with two or three hsv-2 strains (186, 333, and/or g) at a total dose of 1 × 107 pfu of hsv-2 per animal. in ... | 2019 | 30333177 |
| low level expression of the mitochondrial antiviral signaling protein (mavs) associated with long-term nonprogression in siv-infected rhesus macaques. | abnormally increased immune activation is one of the main pathological features of acquired immunodeficiency syndrome (aids). this study aimed to determine whether long-term nonprogression (ltnp) suppresses the upregulation of immune activation and to elucidate the mechanisms whereby the ltnp state is maintained. | 2018 | 30326919 |
| analysis of igg anti-hev antibody protective levels during hepatitis e virus reinfection in experimentally infected rhesus macaques. | secondary spread of hepatitis e virus (hev) infection occurs often in endemic settings in developing countries. the host immune signatures contributing to protection against subsequent hev reinfection are unknown. | 2019 | 30325442 |
| lawful tracking of visual motion in humans, macaques, and marmosets in a naturalistic, continuous, and untrained behavioral context. | much study of the visual system has focused on how humans and monkeys integrate moving stimuli over space and time. such assessments of spatiotemporal integration provide fundamental grounding for the interpretation of neurophysiological data, as well as how the resulting neural signals support perceptual decisions and behavior. however, the insights supported by classical characterizations of integration performed in humans and rhesus monkeys are potentially limited with respect to both general ... | 2018 | 30322919 |
| single-cell quantitation of mrna and surface protein expression in simian immunodeficiency virus-infected cd4+ t cells isolated from rhesus macaques. | single-cell analysis is an important tool for dissecting heterogeneous populations of cells. the identification and isolation of rare cells can be difficult. to overcome this challenge, a methodology combining indexed flow cytometry and high-throughput multiplexed quantitative polymerase chain reaction (qpcr) was developed. the objective was to identify and characterize simian immunodeficiency virus (siv)-infected cells present within rhesus macaques. through quantitation of surface protein by f ... | 2018 | 30320741 |
| a comprehensive analysis of the t and b lymphocytes repertoire shaped by hiv vaccines. | the exploitation of various human immunodeficiency virus type-1 (hiv-1) vaccines has posed great challenges for the researchers in precisely evaluating the vaccine-induced immune responses, however, the understanding of vaccination response suffers from the lack of unbiased characterization of the immune landscape. the rapid development of high throughput sequencing (hts) makes it possible to scrutinize the extremely complicated immunological responses during vaccination. in the current study, t ... | 2018 | 30319643 |
| the role of the motor system in action understanding and communication: evidence from human infants and non-human primates. | there is growing evidence that activation of the motor system during observation of actions, a phenomenon first observed in non-human primates, underlies action understanding and even communication. this review (a) examines the evidence on motor system activity as an underlying neural correlate of action understanding; (b) reviews the theoretical and empirical work linking action understanding and the development of communication, with a specific focus on the role that gestures play as an interm ... | 2019 | 30315570 |
| comparative genome-wide survey of single nucleotide variation uncovers the genetic diversity and potential biomedical applications among six macaca species. | macaca is of great importance in evolutionary and biomedical research. aiming at elucidating genetic diversity patterns and potential biomedical applications of macaques, we characterized single nucleotide variations (snvs) of six macaca species based on the reference genome of macaca mulatta. using eight whole-genome sequences, representing the most comprehensive genomic snv study in macaca to date, we focused on discovery and comparison of nonsynonymous snvs (nssnvs) with bioinformatic tools. ... | 2018 | 30314376 |