Publications

[round table on the current status of vascular surgery].		2009	2729653
low nanogram detection of nucleotides using fast atom bombardment-mass spectrometry.	the effect of trimethylsilyl (tms) derivatization on detection limits of mononucleotides in fast atom bombardment-mass spectrometry (fab-ms) was examined. fab-ms methods were developed to optimize sensitivity using adenosine 5'-monophosphate as a model compound and then applied to reference standards of two clinically important nucleotides: tricyclic nucleoside-5'-monophosphate (tcnmp) and 5-fluoro-2'-deoxyuridine-5'-monophosphate (fdump). the detection limit for the tms derivative of tcnmp was ...	2009	2729562
negative ion fast atom bombardment mass spectrometry for native gangliosides using a neutral matrix.	a hexamethylphosphoric triamide proved to be a useful solvent for negative ion fast atom bombardment mass spectrometry (fabms) of underivatized gangliosides, using a conventional glycerol matrix. analysis of the gangliosides using a hexamethylphosphoric triamide was more convenient and more efficient not only for molecular weight determination but also for elucidating the structure of the carbohydrate sequence. we also noted the significance of the high polarity of the solvent as well as the ele ...	1989	2729549
negative ion fast atom bombardment mass spectrometry for native gangliosides using a neutral matrix.	a hexamethylphosphoric triamide proved to be a useful solvent for negative ion fast atom bombardment mass spectrometry (fabms) of underivatized gangliosides, using a conventional glycerol matrix. analysis of the gangliosides using a hexamethylphosphoric triamide was more convenient and more efficient not only for molecular weight determination but also for elucidating the structure of the carbohydrate sequence. we also noted the significance of the high polarity of the solvent as well as the ele ...	1989	2729549
correction of microcytosis following elimination of an occult source of aluminum contamination of dialysate.	a higher prevalence of aluminum-associated microcytic anemia was noted in hemodialysis unit a (n = 67) compared to unit b (n = 39). this finding could not be explained by differences in the aluminum content of reverse osmosis (ro) water or intake of antacids containing aluminum by patients in the two units. an intermittent source of aluminum contamination was suspected when water aluminum and total dissolved solutes (tds) were measured at several sites in the water treatment facility of unit a. ...	2009	2729267
distribution of different fiber types in whole cross-sections of human platysma. a histological and morphometric study.	analysis of cryostat cross-sections of the entire platysma muscle from human autopsies revealed enzyme histochemical and morphometric differences between normal human limb and facial muscles. the mean diameter of platysma fibers was about 50% of that of normal limb muscle fibers. fiber type diameter increased from the medial to the lateral parts of the platysma. a variability coefficient of 356 indicated great variation in fiber caliber, with many fibers of 10 microns and less. type i fibers sho ...	1989	2728841
[use of the dna-dna hybridization method on filters for determining the toxic potency of atypical strains of vibrio cholerae isolated from natural sources].	the methods of the radioimmunoassay and the blot hybridization of restricted fragments of chromosomal dna have been used for the characterization of v. cholerae atypical strains isolated from the natural environment. for all strains under study, the radioimmunoassay has been found to yield the most sharply defined data characterizing their atoxigenicity. the absence of the structural genes of toxin in the chromosomes of these strains has been shown by the method of blot hybridization. some metho ...	1989	2728700
[minimal osteosynthesis of fractures of the head of the humerus. indications, technic, results].	between 1983 and 1987 minimal osteosynthesis for proximal humeral fractures was performed in 30 patients, 23 women and 7 men, with an average age of 58.5 years. according to the neer classification there were 10 two-part, 9 three-part and 11 four-part fractures. internal fixation was achieved with kirschner wire (n = 9), cancellous screws (n = 4) or tension band (n = 17). the technique of internal fixation with kirschner wire and lateral tension band is described. follow-up examination was possi ...	2009	2727711
[aerosol therapy (3). the ultrasonic nebulizer].		2009	2727484
molindone: effects in pigeons responding under conditional discrimination tasks.	pigeons were trained to respond under three conditional discrimination procedures; 1) a fixed-consecutive-number procedure with (fcn 8-sd) and without (fcn 8) an added external discriminative stimulus, 2) a delayed matching-to-sample (dmts) procedure using 0-sec, 2-sec and 8-sec delay intervals, and 3) a repeated acquisition of behavioral chains (ra) procedure using a four-link response chain with three stimulus keys. the atypical neuroleptic agent molindone decreased accuracy under the fcn 8 at ...	2009	2727003
conjugated diene production after airway acid aspiration.		1989	2726984
discussion of diffusion of medical innovations.		2009	2726946
[the best ways of the control of inflammatory diseases of the lung].	three approaches to optimal control of inflammatory diseases of the lungs are described. the first approach includes improvement of the diagnostic procedure. the second approach is based on development of new complexes of drug therapy and organization of nondrug therapy. the third approach is prophylactic. the main goals of the approaches are formulated.	2009	2726713
electrical and mechanical properties of spontaneous contraction in hypertensive rat portal vein.	contractile and electrical activities of longitudinal smooth muscle of portal vein from normotensive wistar kyoto rats (wky) and stroke-prone spontaneously hypertensive rats (shrsp) were compared. amplitude and duration of spontaneous contraction of shrsp portal vein were greater than those of wky portal vein. no significant differences were observed in the resting membrane potentials between these preparations. spontaneous spike activity appeared as a form of bursts. duration of the burst and t ...	1989	2726435
the battered nurse executive.		2007	2725981
effects of reserpine on dopamine metabolite in the nucleus accumbens and locomotor activity in freely moving rats.	the effect of reserpine (2 mg/kg i.p.) on both locomotor activity and the turnover of dopamine metabolite in the rat nucleus accumbens was estimated by using an activity monitor (animex) and by in vivo brain microdialysis. three to five hours after reserpine administration locomotor activity was reduced and there was a concomitant increase in the level of the dopamine metabolite, homovanillic these findings suggest that depletion of dopamine from the nucleus accumbens may result in decreased loc ...	1989	2725828
a child with phenotypic laron dwarfism and normal somatomedin levels.		2009	2725626
industrial marketing and medical ethics.		2009	2725621
the residency years.		2009	2725620
pattern of malformations in the children of women treated with carbamazepine during pregnancy.	in an attempt to determine whether and to what extent carbamazepine is teratogenic, we evaluated eight children whom we identified retrospectively as having had prenatal exposure to carbamazepine alone or in combination with a variety of anticonvulsants other than phenytoin. in addition, in a prospective study, we documented the outcome of the pregnancies of 72 women who contacted us early in pregnancy because they were concerned about the potential teratogenicity of carbamazepine. a pattern of ...	2009	2725616
case records of the massachusetts general hospital. weekly clinicopathological exercises. case 24-1989. a 77-year-old man with back pain and acute inability to walk.		1989	2725601
primary structures of sm31/32 diagnostic proteins of schistosoma mansoni and their identification as proteases.	we have constructed cdna clones containing the complete nucleotide sequences coding for two highly antigenic schistosoma mansoni adult worm proteins, sm31 and sm32. the predicted amino acid sequence of sm31 shows significant homology to mouse, rat and human cathepsin b. the nucleotide sequence of sm32 is identical to that reported by others for s. mansoni "haemoglobinase'. the different nucleotide sequences demonstrate the existence of two different proteolytic enzymes, both of which are synthes ...	1989	2725581
myopathy and accumulation of amiodarone.		2009	2725579
characterization and purification of h1tf2, a novel ccaat-binding protein that interacts with a histone h1 subtype-specific consensus element.	definition of mechanisms regulating human histone h1 gene transcription during the cell cycle requires the isolation and biochemical characterization of protein factors which interact with specific promoter elements. two distinct binding activities have been identified in nuclear extracts from hela cells and mapped within a 180-base-pair (bp) region of a cell cycle-regulated h1 gene promoter. h1tf1 bound to an h1-specific a + c-rich sequence (ac box), 100 bp upstream of the cap site; h1tf2 inter ...	1989	2725515
electrophoretic analysis of histoplasma capsulatum chromosomal dna.	seven chromosome-sized dna molecules in the downs strain of histoplasma capsulatum were resolved by using chromosome-specific dna probes in blot hybridizations of contour-clamped homogeneous electric field (chef) and field-inversion gel electrophoresis (fige) agarose gels. the sizes of the chromosomal dna bands extended from that of the largest saccharomyces cerevisiae chromosome to beyond that of the schizosaccharomyces pombe chromosomes. under our experimental conditions, the order of the five ...	1989	2725508
tetrahydroaminoacridine and other allosteric antagonists of hippocampal m1 muscarine receptors.	tetrahydroaminoacridine (tha) and a variety of other nonclassical antagonists of muscarine receptors were studied for their ability to bind to primary and allosteric sites on muscarine receptors in rabbit hippocampal membranes. competition curves between 13 antagonists and 1 nm [3h]pirenzepine (kd = 3 nm) were simple mass action curves, but tha produced steeper curves, indicating positive cooperativity. nonetheless, tha inhibited the binding of low concentrations of [3h]pirenzepine, [3h]n-methyl ...	1989	2725474
primary structures of cytochrome p-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome p-450 gene subfamily ivb.	the primary structure of rabbit cytochrome p-450 isozyme 5 has been derived from the nucleotide sequence of cloned cdna. identical sequences were obtained for cdnas constructed with mrna from four different sources, lung and liver of untreated rabbits and liver from rabbits treated once or four times with phenobarbital. isozyme 5 shows significant sequence identity only with rabbit p-450p2 (54%) and rat p-450la omega (53%), which places it in a previously unrecognized cytochrome p-450 gene subfa ...	1989	2725471
alterations in offspring behavior induced by chronic prenatal cocaine dosing.	sperm-positive female long-evans hooded rats were dosed subcutaneously with 10 mg/kg/day cocaine or an equal volume of vehicle (0.9% sterile saline) from gestation day 4 (gd4) through gd18. offspring were assessed for development of negative geotaxis, righting reflex, spontaneous alternation, and open field activity, and for adult behaviors including drl-20 acquisition, water maze, visual discrimination, barbiturate sleep time, shuttlebox avoidance, footshock sensitivity, and tail flick latency. ...	1989	2725438
[incidence of cholera outbreaks in the world: distribution in the environment and imported seafoods].		1989	2724570
[current status of imported infectious diseases and control policy of the ministry of health and welfare].		1989	2724553
incidence of local complications after intramedullary nailing and after plate fixation of femoral shaft fractures.	a consecutive series of 378 patients with 381 acute adult femoral shaft fractures in previously intact femora admitted during a 10-year period was reviewed for the incidence of local complications including malunion. the majority, 282 fractures (74%), were caused by motor vehicle accidents. the median age of the patients was 28 years. the policy of management was internal fixation of the fracture on the day of admission. the method of treatment was intramedullary nailing (küntscher or interlocki ...	2009	2724381
identification of some antigenically related outer-membrane proteins of strains of vibrio cholerae o1 and non-o1 serovars involved in intestinal adhesion and the protective role of antibodies to them.	outer-membrane proteins (omps) of vibrio cholerae strains of o1 and non-o1 serovars were studied. marked similarity was found in the omp profiles of different v. cholerae o1 strains but the omp profile of a non-o1 strain was somewhat different. antigenic relatedness between the omps of different v. cholerae strains was established by enzyme-linked immunosorbent assay (elisa). immunoblotting experiments demonstrated that at least two omps of 36 and 25-26 kda were immunogenic and common to strains ...	1989	2724325
synthesis and biological evaluation of s-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase.	as part of a continuing search for specific inhibitors of the enzymes involved in polyamine biosynthesis, we have designed and synthesized a multisubstrate adduct inhibitor, s-adenosyl-1,12-diamino-3-thio-9-azadodecane (adodatad), in which critical portions of the nucleophilic aminopropyl acceptor are covalently linked to critical portions of the electrophilic aminopropyl donor to form a potent and specific inhibitor of spermine synthase. in addition, the corresponding desamino analogue which wa ...	1989	2724300
how accurate are faculty evaluations of clinical competence?	to determine the degree and sources of variability faculty evaluations of residents for the american board of internal medicine (abim) clinical evaluation exercise (cex).	2009	2723833
role of extracellular space in hyperosmotic suppression of potassium-induced electrographic seizures.	1. focal electrographic seizures arose in the ca1 region of rat hippocampal slices bathed in elevated (8.5 mm) external potassium [( k+]o). high [k+]o also induced spontaneous interictal bursts that originated in area ca3 and propagated to ca1. to examine the contribution to electrographic seizure initiation of excitatory mechanisms that are influenced by extracellular volume, we studied the effect of hyperosmotic expansion of interstitial volume on seizure occurrence, interictal bursts, and exc ...	1989	2723735
can the family physician avoid conflict of interest in the gatekeeper role? an affirmative view.		2000	2723596
the effects of amphetamine on synaptic plasticity in rat's medial prefrontal cortex.	morphometric analysis of medial prefrontal cortex (layer vi) of rats treated daily with amphetamine in a dose of 2.5 mg/kg during 3 weeks was performed on the electron microscopic level. the efficacy of the amphetamine dosage was tested on behavioral observation. synapses on dendritic shafts and spines were studied. the density of axo-dendritic synapses increase on 74%, while the density of synapses on spine's neck decreased on 53%. most synaptic parameters measured in axo-dendritic (1) and axo- ...	1989	2723411
bilateral chorioretinitis, centripetal optic neuritis, and encephalitis in a llama.	blindness characterized by dilated, unresponsive pupils and ophthalmoscopic evidence of optic nerve atrophy and retinal degeneration developed in a 5-year-old llama. lesions were not progressive during 2 months of observation. the llama was euthanatized and necropsied. histopathologic findings included chorioretinitis, optic neuritis, and encephalitis characterized by mononuclear perivascular infiltration. attempts to prove an infectious cause were unsuccessful.	1989	2722665
vibrio cholerae expresses cell surface antigens during intestinal infection which are not expressed during in vitro culture.	vibrio cholerae o1 bacteria harvested directly from ligated or nonligated intestines of rabbits with experimental cholera expressed at least 7 to 8 novel, in vivo-specific cell envelope (env) proteins that were not found on vibrios after in vitro culture in various ordinary liquid media. at the same time, several of the env proteins ordinarily expressed in vitro had disappeared or become much reduced. the infection-induced novel env protein were immunogenic. in immunoblot analyses, antisera rais ...	1989	2722240
protection by desferrioxamine against histopathological changes of the liver in the post-oligaemic phase of clinical haemorrhagic shock in dogs: correlation with improved survival rate and recovery.	haemorrhagic shock was produced in anaesthetized dogs, by rapid arterial bleeding to mean arterial blood pressure 35 mmhg, and maintained oligaemic for 4 h followed by return of withdrawn blood(rowb). dogs were observed for 72 h after rowb for survival and recovery, and, for histopathological (hp) studies on liver, dogs were sacrificed 2 h after rowb in non-survival experiments. desferrioxamine mesylate (25 mg/kg) was administered intra-muscularly at 2,3 and 4 h after blood loss in survival expe ...	1989	2722020
[the classification of industrial chemical allergens].	the classification of industrial chemical allergenic compounds has been developed. the criterion of noxious effect of allergenic chemicals is described not only by experimentally valid allergenic signs of the compound but also by clinical manifestations of allergosis in workers and sanitary diagnostic reliability of occupational allergic diseases. numerous allergens are classified according to the chemical systematization of compounds. the classification contains 2 classes: the 1st class involve ...	2006	2722011
a light microscopic and autoradiographic study of non-irradiated and irradiated ocular wounds.	focal gamma irradiation was used to limit the intraocular extension of scar tissue which typically occurs after posterior perforating injury to the eye. standard posterior perforating injuries were created in the right eye of forty-eight rabbits, half of which had the site of perforation focally irradiated using a cobalt 60 ophthalmic plaque. non-irradiated wounds healed with profuse formation of highly cellular and vascularised granulation tissue which invaded the vitreous to form contractile v ...	1989	2721224
a light microscopic and autoradiographic study of non-irradiated and irradiated ocular wounds.	focal gamma irradiation was used to limit the intraocular extension of scar tissue which typically occurs after posterior perforating injury to the eye. standard posterior perforating injuries were created in the right eye of forty-eight rabbits, half of which had the site of perforation focally irradiated using a cobalt 60 ophthalmic plaque. non-irradiated wounds healed with profuse formation of highly cellular and vascularised granulation tissue which invaded the vitreous to form contractile v ...	1989	2721224
composition of very-low-density lipoproteins in non-insulin-dependent diabetes mellitus.	we studied the characteristics of very-low-density lipoproteins (vldls) composition in patients with non-insulin-dependent diabetes mellitus. vldls were isolated from 28 diabetics and 33 nondiabetics with a wide range of plasma lipid concentrations, so we could compare vldl composition between the two groups at similar lipid concentrations. the mean cholesterol and triglyceride concentrations in plasma of diabetic subjects were 2170 (sd 570) and 2510 (sd 2230) mg/l, respectively, and 2230 (sd 56 ...	2009	2720974
complications of cardiac catheterization and angiography in patients with valvular heart disease. va cooperative study on valvular heart disease.	complications were surveyed prospectively in 2,029 catheterizations performed on 1,483 patients from the 13 centers participating in the va cooperative study on valvular heart disease. complications were reported in 6.9% of 1,559 preoperative procedures of which 2.6% were major and 0.2% fatal. clinical predictors of complications were hypertension and the precatheterization diagnosis of aortic stenosis. nevertheless, patients with aortic stenosis successfully tolerated left ventriculography, whi ...	2009	2720763
non-oi vibrio cholerae septicemia associated with a motor vehicle accident.		1989	2720517
genetic susceptibility to environmental mutagens and carcinogens.		2008	2720142
on the kinetic depth effect.	the problem of the kinetic depth effect is revisited. we study how many points in how many views are necessary and sufficient to recover structure. the constraints in the cases where the velocities of the image points are known, and the positions of the image points are known with the correspondence between them established, are different and they have to be studied separately. in the case of two projections of any number of points there are infinitely many solutions, but if we regularize the pr ...	2008	2719982
preventing infant mortality.		2009	2719787
genetic and environmental contributions to the covariance between occupational status, educational attainment, and iq: a study of twins.	scores of occupational status, educational attainment, and iq were obtained for 507 monozygotic and 575 dizygotic male twin pairs born 1931-1935 and 1944-1960. a multivariate genetic analysis with statistics from different cohorts showed heterogeneity between cohorts, and analyses were performed in four separate cohorts. the only set of results which departed clearly from the rest was found for the group born 1931-1935, where the ratio of environmental to genetic effects exceeded those of the ot ...	2009	2719624
[viral infection and obstructive cholangiography in children].	in the last years it has been suggested that idiopathic obstructive cholangiopathy is a pathologic process with evolutive studies: extrahepatic biliary atresia and neonatal hepatitis. the possibility of a viral agent as the inciting factor has been investigated. this report shows four male and one female with confirmed idiopathic obstructive cholangiopathy with different clinical picture. there was evidence of cytomegalovirus infection in two patients, rubella infection in one patient, hepatitis ...	1989	2719422
analysis of the quantitative relationship between anemia and chronic renal failure.	the authors analyzed data from 106 adults with chronic renal failure [(crf), serum creatinine (scr) greater than 132.6 mumol/l (1.5 mg/dl)], to define the precision of, and effects of covariables on, the relationship between anemia and crf. we excluded dialyzed or patients who had received transplants and those with obvious potential nonrenal causes of anemia. hct was a linear function of bun and scr (r = -0.48, and r = -0.67, respectively), and a curvilinear function of creatinine clearance (r ...	2009	2719057
improved catheter introducer with recessed sheath.		2009	2718884
survival and weight increase in the fetal rat after selective hypophysectomy in utero.	rat fetuses were subjected to selective hypophysectomy in utero on day 16, 17 or 18 of gestation and inspected on day 22 (the day before birth). the survival rate of fetuses operated on day 17 and 18 was about 20 and 50%, respectively. losses were mostly caused by the surgery preceding the removal of the pituitary, and no significant survival-promoting activity of the gland could be demonstrated. the surgical injuries, as such, also reduced the weight increase substantially. still, the loss of t ...	1989	2718734
tumor necrosis factor enhances expression of tissue factor mrna in endothelial cells.	we have examined the effect of recombinant tumor necrosis factor on the expression of tissue factor activity and tissue factor mrna levels in vascular endothelial cells. following exposure of human umbilical vein endothelial cells to this cytokine, the appearance of tissue factor procoagulant activity was detected following cell disruption, and was maximal at 6 hours. northern blot analysis of cytokine-treated cells demonstrated a similar increase in the synthesis of tissue factor mrna, followed ...	1989	2718149
wound hematoma: prophylaxis with topical thrombin.	we studied 123 patients having elective exploratory laparotomy through a midline vertical incision for gynecologic disease; patients were randomized to receive wound irrigation with either saline or topical thrombin before closure of the incision. seven patients were not evaluable. no patient received low-dose heparin therapy perioperatively. no patient in either group had a clinically significant wound hematoma or disruption. minor wound hematomas were more common in the saline group, a finding ...	2009	2717986
epidermal growth factor receptor status and s-phase fractions in gastric carcinoma.	the correlation with epidermal growth factor (egf) receptor expression and clinicopathologic findings were studied in 242 gastric carcinomas. they were stained for egf receptor by means of an immunohistochemical technique using a monoclonal antibody against the receptor. s-phase fractions were measured by in vivo bromodeoxyuridine (brdu) labeling and indirect immunohistochemical staining using anti-brdu monoclonal antibody. in normal gastric epithelium, egf receptor immunoreactivity could not be ...	2009	2717125
patterns of ribosomal rna evolution in salamanders.	sequence comparisons are presented for four segments of the large subunit of ribosomal rna, including divergent domains d7a and d7b, portions of the large divergent domains d2, d3, and d8, and evolutionarily conservative sequences flanking divergent domains. these results resolve phylogenetic relationships among exemplars of seven families of salamanders and the three amphibian orders. phylogenetic analysis confirms the prediction that divergent domains feature the highest relative rates of base ...	2009	2716516
[the primary care physician and the problems of aid to patients with acquired immunodeficiency syndrome].		2009	2716378
blunt injury of the abdominal aorta.		2009	2716321
[fibrinogen, atherosclerosis, inflammation. satellite symposium. angio dyn 88. toulouse, 5 october 1988. proceedings].		2009	2715733
determination of stereo- and positional isomers of oxygenated triterpenoids by reversed phase high performance liquid chromatography.	twenty four oxygenated triterpenoids, including eight pairs of stereoisomers and five pairs of positional isomers, could be separated by reversed phase hplc. the capacity factors obtained in methanol-water and acetonitrile-water solvent systems made it possible to correlate the molecular polarities due to the presence of multiple oxygenated functional groups in these compounds. it was found that the number and position of functional groups as well as the stereochemistry of these functional group ...	2009	2715731
effects of inducers of differentiation on protein kinase c and cmp-n-acetylneuraminic acid:lactosylceramide sialyltransferase activities of hl-60 leukemia cells.	exposure of hl-60 leukemia cells to either 12-o-tetradecanoylphorbol-13-acetate (tpa), dimethylsulfoxide (dmso), exogenous gangliosides gm3, gm1, or bovine brain ganglioside mixture (bbg) resulted in a marked inhibition of the growth of cells. the order of the inhibitory potency was tpa greater than gm3 greater than dmso greater than bbg greater than gm1. in contrast, sulfatides were without effect on cellular replication. treatment of hl-60 cells with tpa or gm3 induced differentiation along th ...	1989	2715723
apolipoprotein b metabolism in homozygous familial hypercholesterolemia.	this report describes the metabolism of apolipoprotein b-containing lipoproteins in seven familial hypercholesterolemic (fh) homozygotes and compares the results to the values obtained from five healthy control subjects. the concentration, composition, and metabolism of large, triglyceride-rich very low density lipoproteins (vldl1, sf 60-400) were the same in the control and fh groups, indicating that this component of the vldl delipidation cascade ws unaffected by the absence of receptors. in c ...	2009	2715722
beyond the learning mystique: an interactional perspective on learning disabilities.		2009	2715715
right vocal cord paralysis after internal jugular vein cannulation.	neurological complications are rare after central venous cannulation. we report a case of right vocal cord paralysis after internal jugular vein cannulation. the mechanism of neural injury is discussed.	2009	2715702
flexible oesophagogastroscopy in otolaryngology.	we describe a technique of flexible endoscopy of the upper aerodigestive tract which provides excellent visualization for diagnostic and therapeutic purposes in ent practice. with the present day need to reduce costs it is helpful to reduce inpatient workload and perform procedures as day cases where appropriate. the previous criticisms of flexible oesophagoscopy by ent surgeons are unfounded and indeed there are situations where flexible endoscopy is superior to rigid examination. we would reco ...	2009	2715694
heparin-associated thrombocytopenia and thrombosis.		2009	2715686
sabbatical leave: an important mechanism for revitalizing faculty.		2009	2715679
comparison of acral nevomelanocytic proliferations in japanese and whites.	the preponderance of malignant melanomas that occur in the japanese population affect the palmar and plantar areas, in contrast to those of whites, which occur predominantly on the head, neck, and trunk. furthermore, a precursor lesion, the dysplastic nevus, has been well defined in nonacral white skin but not in the japanese. in this paper, a similarity between benign and atypical acral nevomelanocytic proliferations in japanese and whites is described. however, it appears that in the japanese ...	2009	2715654
epidemiology and control of melanoma in white populations and in japan.	in white populations living at moderate or low latitudes, melanoma has become one of the most common tumors in young adults. epidemiologic studies show a complex association with sun exposure. risk is related positively to the levels of exposure typical of the place of residence, and also to personally controlled exposure, with the maximum risk being related to acute intermittent exposure. risk also varies with pigmentation, family history of melanoma, and the presence of benign and of dysplasti ...	2009	2715653
acute pseudobulbar palsy due to bilateral focal cortical damage: the opercular syndrome of foix-chavany-marie.	two children are described who suddenly developed an encephalitic illness with intractable bilateral facial seizures. the seizures subsided over several days, but the children were left with the signs of pseudobulbar palsy and are unable to speak or swallow effectively. bilateral destructive lesions in the opercular regions evolved on computed tomographic scans. both children were treated with acyclovir relatively early in the illness, and cerebrospinal fluid and serum antibodies support the dia ...	2009	2715610
congenital choroid plexus papilloma of the fourth ventricle.	a newborn infant with marked hydrocephalus had a large papilloma of the choroid plexus originating in the fourth ventricle and infiltrating the brain stem. the computed tomographic (ct) scan appearance was distinctive, showing vascularity and marked enhancement with contrast medium. histological confirmation was made from several surgical sites. total removal of the tumor was not possible. review of congenital choroid plexus brain tumors reveals the location of this child's tumor in the fourth v ...	2009	2715609
hydranencephaly and maximal hydrocephalus: usefulness of electrophysiological studies for their differentiation.	the eeg was evaluated in three cases of hydranencephaly and two cases of maximal hydrocephalus, and the visual evoked potential was studied in one case each of hydranencephaly and maximal hydrocephalus. the eeg tracing of hydranencephaly typically showed a flat pattern in most bipolar derivations because of the differential amplification of the same activity from remote generators. however, the eeg of maximal hydrocephalus did not demonstrate a flat pattern in bipolar as well as referential deri ...	2009	2715606
epidemiology of iddm in black and white children in jefferson county, alabama, 1979-1985.	for the period of 1 january 1979 through 31 december 1985, an average annual incidence rate (ir) of 12.1/100,000 (95% confidence interval [10.4/100,000, 14.0/100,000]) of insulin-dependent diabetes mellitus (iddm) was observed in jefferson county, alabama, among people less than 20 yr old. hospital medical-record review was the primary source of case ascertainment. a large proportion of black children in the county permitted race-specific analyses. the average annual ir among the black children ...	2009	2714520
effect of estradiol on the phosphorylation of rat liver ribosome proteins.	the effect of estradiol on phosphorylation with gamma-32p-atp of ribosome proteins from polyribosome fraction, isolated from female rat liver is found out. rats (180 g) used were: sham-operated, ovariectomized and treated after ovariectomy for 11 days with 20 micrograms 17 beta-estradiol-dipropionate per 100 g body weight. the estradiol deficiency after ovariectomy decreased phosphorylation, but the estrogenization of ovariectomized rats increases it twice. in vitro the hormone (1-2 mumol/l) [co ...	1989	2714224
examination, by 1h-n.m.r. spectroscopy, of the binding of a synthetic, high-affinity heparin pentasaccharide to human antithrombin iii.	binding of a synthetic, high-affinity heparin pentasaccharide and of intact heparin to both native and elastase-modified human antithrombin iii have been examined by 1h-n.m.r. spectroscopy. the pentasaccharide perturbs many protein resonances in the same way as does intact heparin. there are, however, differences that seem to arise both from fewer contacts in the heparin binding-site when the pentasaccharide binds and from dissimilar conformational changes in the protein. the resonance of the h- ...	1989	2713873
periosteal neochondrogenesis for biologically resurfacing joints: its cellular origin.	the purpose of this study was to determine if the hyaline-like cartilage produced in major full-thickness defects of a joint surface, treated by a free periosteal graft and subjected to continuous passive motion (cpm), originated exclusively from the progenitor cells of the cambium of the graft. free periosteal grafts were raised from the tibia of both hind legs of eight male new zealand rabbits and transplanted into full-thickness defects across the entire width of the patellar groove of 15 fem ...	1989	2713771
periosteal neochondrogenesis for biologically resurfacing joints: its cellular origin.	the purpose of this study was to determine if the hyaline-like cartilage produced in major full-thickness defects of a joint surface, treated by a free periosteal graft and subjected to continuous passive motion (cpm), originated exclusively from the progenitor cells of the cambium of the graft. free periosteal grafts were raised from the tibia of both hind legs of eight male new zealand rabbits and transplanted into full-thickness defects across the entire width of the patellar groove of 15 fem ...	1989	2713771
an attempt to evaluate diagnostic and prognostic significance of blood endogenous ethanol in alcoholics and their relatives.	endogenous ethanol in the blood of human subjects was measured by gas chromatography. in healthy males, 12-13-year-old boys (sons of alcoholic and nonalcoholic fathers), and alcoholic inpatients (after cessation of all drugs), the endogenous ethanol levels ranged from 0 to 4.3 mg/l. the results showed no significant differences between the groups. at the period of alcohol withdrawal reactions the concentrations of endogenous ethanol were minimal in patients with delirium tremens and maximal in p ...	1989	2713093
isopropanol ingestion: case report with pharmacokinetic analysis.	an unusual case of acute isopropanol overdose which occurred within the confines of the emergency department is reported. serial serum concentrations of isopropanol and its metabolite acetone were followed for 43 hours. pharmacokinetic analysis is presented, as well as a brief literature review of diagnosis and management. cns toxicity was related mainly to isopropanol concentrations. the calculated half-life of isopropanol was 7.3 hours. because of the pharmacokinetic profile of isopropanol, ma ...	2009	2712894
[morphology of the palatine tonsil lymphocytes in chronic tonsillitis using data of electron microscopic radioautography].	electron-microscopic and electron-radioautographic examinations of the palatine tonsil lymphocytes in 20 patients with chronic decompensated tonsillitis, aged 21-50, have revealed the proliferation of poorly differentiated t- and b-lymphocyte pools in the lymphoid tissue of the tonsils; these processes manifest by an intensive 3h-thymidine incorporation into the minor lymphocytes of different types. a high level of the rna radioactive precursor incorporation in b-lymphocytes indicates a constant ...	2009	2712729
establishment of the experimental conditions for inducing saccular cerebral aneurysms in primates with special reference to hypertension.	to find out the optimum experimental conditions for the induction of saccular cerebral aneurysms in primates, various procedures for inducing renal hypertension were used in cynomolgus monkeys treated with ligation of unilateral carotid artery and beta-amino-propionitrile feeding. animals were divided into four groups. in the first group, both kidneys were simultaneously compressed with a figure-eight ligation. in the second group, the kidneys were ligated at an interval of one week. in the thir ...	1989	2711898
[preparation and in vitro study of suppositories containing no-spa. i. significance of choosing the basic substance. determination of physical parameters of suppositories].		2009	2711838
new hydrogen-bond potentials for use in determining energetically favorable binding sites on molecules of known structure.	an empirical energy function designed to calculate the interaction energy of a chemical probe group, such as a carbonyl oxygen or an amine nitrogen atom, with a target molecule has been developed. this function is used to determine the sites where ligands, such as drugs, may bind to a chosen target molecule which may be a protein, a nucleic acid, a polysaccharide, or a small organic molecule. the energy function is composed of a lennard-jones, an electrostatic and a hydrogen-bonding term. the la ...	2009	2709375
evaluation of infant feeding in acute gastroenteritis.	sixty-eight bottle-fed babies under 9 months of age with mild acute gastroenteritis were observed to evaluate current feeding regimens following acute gastroenteritis in infancy. all babies were fed for 24 h with a glucose-electrolyte mixture (gem) and then randomly assigned to either a gradual reintroduction to their normal milk, i.e., slow regrade; immediate return to full-strength formula; or a rapid regrade to a hypoallergenic whey hydrolysate formula. all groups were well matched for age, s ...	2009	2709254
stability of vinca alkaloid anticancer drugs in three commonly used infusion fluids.	the chemical stabilities of the vinca alkaloid anticancer drugs vinblastine, vincristine, and vindesine have been studied in three commonly used infusion fluids at 4 and 25 degrees c. the infusion fluids were: 0.9% sodium chloride, 5% dextrose, and ringer's lactate injection. stability has been measured by using a stability-indicating high performance liquid chromatographic assay with ultraviolet detection. at 4 degrees c no significant degradation of the vinca alkaloids occurred within a storag ...	2009	2709240
allocation and the physician: the impacts of aging and aids.		2009	2709175
lumboperitoneal shunt combined with myelotomy for treatment of syringohydromyelia.	this study was undertaken to investigate whether a direct communication between the fourth ventricle and the syrinx exists in the majority of patients with syringohydromelia and whether intraspinal pressure plays a role in the pathogenesis of this disorder. a series of 13 patients with syringohydromyelia delineated by magnetic resonance (mr) imaging was reviewed, and the intracranial pressure (icp) and lumbar spinal pressure (lsp) were recorded concomitantly in three patients. lumboperitoneal sh ...	2009	2709113
neurogenesis of glutamic acid decarboxylase immunoreactive cells in the hippocampus of the mouse. i: regio superior and regio inferior.	the neurogenetic gradients of neurons showing glutamic acid decarboxylase (gad) immunoreactivity were determined in the regio superior and in the regio inferior of the mouse hippocampus. pregnant c57bl mice received pulse injections of (3h)thymidine from e11 through e17 (e0 being the day of mating). distributions of (3h)thymidine-labeled, gad-positive neurons in the different strata of the hippocampus proper were recorded in adult animals. gad-positive neurons in this region are generated prenat ...	1989	2708583
ultrastructural analysis of axosomatic contacts on functionally identified primate spinothalamic tract neurons.	the morphology and frequency of axosomatic contacts on three functionally identified primate spinothalamic tract (stt) cells were analyzed at the electron microscopic level. the stt cells analyzed were wide-dynamic-range neurons responsive to activation of low- and high-threshold cutaneous afferents innervating the foot. the somas were located in the lateral border of lamina v; the dendritic trees were oriented dorsally and were very extensive. numerous spinelike appendages were observed emanati ...	2009	2708581
a case of acute psychosis in temporal association with theophylline toxicity.		2009	2708558
reduced renal clearance of oxypurinol during a 400 calorie protein-free diet.	a decrease in dietary protein intake lowers the clearance of a number of substances excreted principally by the kidney including uric acid and oxypurinol, the major metabolite of allopurinol. we studied the kinetics of uric acid and oxypurinol in seven healthy volunteers on a normal protein diet (2600 calories; 100 g protein) followed by a 400 calorie, protein-free diet. a 600 mg dose of allopurinol was given orally after 6 days of the normal protein diet and again after 2 days of the 400 calori ...	2009	2708550
effects of coadministration of propafenone on the pharmacokinetics of digoxin in healthy volunteer subjects.	previous reports have suggested an interaction between propafenone and digoxin. we investigated the pharmacokinetics of iv digoxin when given alone (phase i), after pretreatment with propafenone 150 mg every 8 hours for seven days (phase ii), and after propafenone 300 mg every 8 hours for 7 days (phase iii). the total body clearance of digoxin during phase i was 2.45 ml/min/kg and was 2.17 ml/min/kg during phase ii (ns) and decreased to 1.92 ml/min/kg during phase iii (p less than 0.05). the ren ...	2009	2708548
determination of elastase activity by reversed-phase high-performance liquid chromatography.	the action of elastase on elastin was measured by high-performance liquid chromatography with on-line post-column derivatization. after alkaline hydrolysis, a 20-ml sample was injected into a ods-2 gel column. an elastin-specific dipeptide, val-pro, and the internal standard, gly-leu, were eluted by a linear gradient of 0 to 10% of 1-propanol in 50 mm heptafluorobutyrate (ph 3) at a flow-rate of 1 ml/min. the eluent was reacted with fluorescamine, and the fluorescent products were measured. rete ...	2009	2708474
development of personality and intelligence in children with congenital heart disease.	one hundred and twenty-eight children with congenital heart disease (chd) and 89 healthy controls were compared according to their development of personality and intelligence. presence of physical disability in daily life was the independent variable for dividing children with chd into two groups: children with physical handicap due to chd (n = 77) have lower iq scores than healthy children. unexpectedly, in the parents' opinion they show no difference in behaviour patterns. on introspective exa ...	2009	2708467
cortisol induction of metallothionein in primary culture of rainbow trout hepatocytes.	in the present experiment, metabolically active primary cultures of rainbow trout hepatocytes were utilized to study the inducibility of metallothionein after cortisol treatment. glucocorticoid induction of metallothionein has previously only been demonstrated in mammalian systems. we now demonstrate the inducibility of rainbow trout metallothionein by cortisol treatment of primary hepatocytes. a 90% elevation above control levels was achieved within 8 days of treatment. zinc treatment was perfo ...	2009	2708457
when headaches are good.	occasionally patients with headache present with the complaint of "a really good one." this paper examines three cases of patients with migraine who often referred to their headaches as "good." when the patients were asked what made the headaches good, they immediately tried to clarify their terminology as "just a figure of speech" that really meant bad. further exploration usually revealed the headache symptoms had indeed been "good" in a relative sense, in that it had somehow served to help th ...	2008	2708037
when headaches are good.	occasionally patients with headache present with the complaint of "a really good one." this paper examines three cases of patients with migraine who often referred to their headaches as "good." when the patients were asked what made the headaches good, they immediately tried to clarify their terminology as "just a figure of speech" that really meant bad. further exploration usually revealed the headache symptoms had indeed been "good" in a relative sense, in that it had somehow served to help th ...	2008	2708037
increased hepatic lipid peroxidation with methionine toxicity in the rat.	consumption of excess methionine by rats is known to cause membrane damage, liver enlargement and accumulation of iron in the spleen. in this study two groups (n = 5) of male, wistar rats were pair-fed either a methionine supplemented (20.0 g/kg) or control (2.0 g/kg) diet for 7 weeks. hepatic and erythrocyte copper-zinc superoxide dismutase activities were significantly reduced (p less than 0.05 and p less than 0.001 respectively) by methionine supplementation while the activities of catalase ( ...	1989	2707623