Publications

rapid decline of clonogenic hemopoietic progenitors in semisolid cultures of bone marrow samples derived from patients with chronic myeloid leukemia.	bone marrow samples, from newly diagnosed patients with chronic myeloid leukemia (cml) and normal individuals, were grown in methylcellulose and serially recultured under identical conditions. specimens derived from normal individuals gave rise to multilineage and megakaryocyte colonies for one to two sequential cultures. erythroid bursts and granulocyte-macrophage colonies were observed for three to five sequential cultures. cultures initiated from samples of patients with cml showed a rapid de ...	2009	2768845
vibrio cholerae non-serogroup o1 cystitis.	we report a case of a patient who developed cystitis caused by non-serogroup o1 vibrio cholerae after swimming in the chesapeake bay. treatment was empirical, with complete symptomatic resolution. genitourinary tract infections by vibrio spp. are uncommon but should be considered when cystitis occurs after saltwater exposure in appropriate geographic regions.	1989	2768474
detection of trypsin- and chymotrypsin-like proteases using p-nitroanilide substrates after sodium dodecyl sulphate polyacrylamide gel electrophoresis.	specific chromogenic p-nitroanilide substrates have proved useful for localizing proteolytic enzymes, such as trypsin, chymotrypsin and elastase after separation by agarose gel electrophoresis and when immobilized on nitrocellulose. this procedure was further developed for use with sodium dodecyl sulphate-polyacrylamide gel electrophoresis (sds-page). after sds-page, proteins were transferred electrophoretically to a nitrocellulose membrane. the membrane was incubated for 10-60 min with bz-ile-g ...	1989	2768384
exclusion of clinically atypical or microbiologically mixed diarrhoeal episodes from outcome events in a field trial of oral cholera vaccines.	we investigated whether alternative clinical and microbiological criteria for outcome events affected estimates of vaccine efficacy in a randomized, double-blind field trial of b subunit-killed whole cell (bs-wc) and killed whole cell-only (wc) oral cholera vaccines among 62,285 rural bangladeshi participants. at one year of follow-up estimates of vaccine protective efficacy (pe = 60%, p less than 0.0001 for bs-wc; pe = 54%, p less than 0.0001 for wc) against all treated diarrhoeal episodes asso ...	1989	2767860
cultural contributions to constructing locus-of-control attributions.	locus of control attribution patterns have been demonstrated to predict a variety of behavioral and adaptational characteristics in a number of societies. as a consequence, questions concerning the comparability of those attributions across cultures have been of interest to social and personality theorists as well as to their more action-oriented colleagues. in the present study, the processes used by indian college students to form those attributions have been studied and compared with those us ...	2009	2767420
transcriptional start site in the mouse cyp1a1 (cytochrome p1450) gene.	two transcriptional initiation sites have been described by different laboratories for the mouse cyp1a1 (cytochrome p1450) gene: start site ti, at the beginning of the nontranslated 87-bp first exon, and start site tii, 635 bp downstream from site ti within the 2,380-bp first intron. site ti was characterized in normal c57bl/6 mouse liver, whereas site tii was described in a high activity variant line (hav cells) derived from the mouse hepatoma hepa-1c1c7 wild type (wt) established cell line. it ...	1989	2766934
treatment of childhood bacterial meningitis with ceftriaxone once daily: open, prospective, randomized, comparative study of short-course versus standard-length therapy.	fifty-two children were included in this study to evaluate and compare short- versus standard-length ceftriaxone therapy for bacterial meningitis. the duration of the short-course regimens was 4, 6 and 7 days for neisseria meningitidis, hemophilus influenzae and streptococcus pneumoniae, respectively. the standard-length regimens were twice as long. on the basis of a computer-generated randomization list, 26 children were assigned either to the short- or to the standard-treatment regimen. ceftri ...	1989	2766869
improved subclavian introduction technique of the pulmonary artery catheter sheath.		2009	2766775
purification and partial characterization of a cytotonic enterotoxin produced by aeromonas hydrophila.	this report describes the purification and partial characterization of a cytotonic enterotoxin produced by a human diarrheal isolate (ssu) of aeromonas hydrophila. the extracellular enterotoxin was purified by (nh4)2so4 precipitation, hydrophobic column chromatography, and chromatofocusing. the highly purified enterotoxin exhibited a molecular mass of 44 kda and an isoelectric point in the range of 4.3 - 5.5 as determined by chromatofocusing. western blot analysis using aeromonas anti-enterotoxi ...	1989	2766121
factors affecting the colonization of isolated rabbit intestinal epithelial cells by vibrio cholerae 01 in vitro.	the adhesive capability of vibrio cholerae 01 strains to isolated rabbit intestinal epithelial cells was maximally expressed when the bacteria were grown in synthetic broth and was enhanced by the presence of ca2+ in the growth media. n-acetyl-d-glucosamine could inhibit the adhesion of the bacteria to rabbit intestinal epithelial cells as could lipopolysaccharide o-antigen from vibrio cholerae 01 and lectin from triticum vulgaris. since the lipopolysaccharide is known to contain n-acetyl-d-gluc ...	1989	2766118
hamster circadian rhythms are phase-shifted by electrical stimulation of the geniculo-hypothalamic tract.	the suprachiasmatic nuclei (scn) contain the major pacemaker for mammalian circadian rhythms. the scn receive photic input both directly, via the retinohypothalamic tract (rht), and indirectly, via the geniculohypothalamic tract (ght), which originates in cells in the intergeniculate leaflet (igl) and anterior portions of the ventral lateral geniculate nucleus (vlgn). we tested whether electrical stimulation of the ght would induce phase shifts in wheel-running activity rhythms of syrian hamster ...	1989	2765900
[prospects for measuring the rheologic characteristics of human soft tissues based on the recording of their transverse rigidity].	it is shown by an example of a forearm that to determine objective characteristics of rheological properties of soft human tissues by measuring their transverse stiffness (k) one should first investigate the relation between k and the diameter of the used indentor (d). the nonlinearity of the dependence k(d) for indentor diameters from 2 to 8 mm is demonstrated and it is assumed that this nonlinearity is due to heterogeneity of tissue properties in the directions normal to the axis of force acti ...	1989	2765581
[the role of tracking in the perception of objects, moving toward each other in a narrow vertical slit line].	it has been shown by means of calculation and device modeling that the observed subjective pressure of two objects moving toward one another behind a narrow vertical slit corresponds to the pressure of objects retinal projections, induced in its turn by a slowed down tracing. 180e turn of one of the moving objects is also explained by tracing.	2009	2765575
[clinical manifestations of infection by human immunodeficiency virus in children].	hiv infection in children presents a wide spectrum of clinical manifestations, from asymptomatic to opportunistic infections, neurologic deterioration and malignancy. this retrospective study describes the characteristics of 30 hiv infected children, attended at the hospital infantil de méxico. six patients were asymptomatic and 24 symptomatic. twenty four patients presented a secondary infection, 66% opportunistic infections, compared against the 100% who presented around 3 serious bacterial in ...	1989	2765158
effects of antibodies against chicken riboflavin carrier protein on fetal hepatic cell ultrastructure.	day 12 pregnant mice administered antibodies to crcp exhibited riboflavin deprival, which resulted in progressive alteration in the fetal hepatic cell structure, which eventually led to fetal wastage and termination of pregnancy. these changes were evident as early as 1 h following antiserum treatment. three hours following treatment, other degenerative changes such as disorganization of glycogen particles and endoplasmic reticulum and degranulation of mitochondria were observed. nuclear pycnosi ...	1989	2765133
high altitude can accurately be simulated by using altered oxygen concentrations.		2009	2764856
effects of co-administration of di(2-ethylhexyl)phthalate and testosterone on several parameters in the testis and pharmacokinetics of its mono-de-esterified metabolite.	the administration of 1 g/kg di(2-ethylhexyl)phthalate (dehp) or 5 mg/kg testosterone for 1 week did not affect the testicular and prostatic gland weights in rats. however, co-administration of dehp and testosterone induced severe testicular atrophy accompanied by a decrease of zinc concentration in the testis and reduction of the activity of testicular specific lactate dehydrogenase isozyme. these changes were similar to the results of high dose administration of dehp alone. values of biologica ...	1989	2764717
ecology of vibrio cholerae non-o1 and salmonella spp. and role of zooplankton in their seasonal distribution in fukuyama coastal waters, japan.	seasonal variation of human pathogens such as vibrio cholerae non-01 and salmonella spp. in fukuyama coastal waters and the role of zooplankton in their distribution were studies for a period of 1 year. comparison of two established methods, viz., the elevated temperature method and the two-step enrichment method of enumerating v. cholerae, showed that the former is superior in the recoveries of v. cholerae non-01. isolation of this pathogen on a wider range of salinities (0.4 to 32.5%) revealed ...	1989	2764569
experimental atherosclerosis and oxygen free radicals.	oxygen free radicals are known to produce cellular injury by peroxidation of phospholipids in the cell membrane. these free radicals might damage the endothelial cell and thus set the stage for atherosclerosis. the authors studied the effect of high-cholesterol diets on the genesis of atherosclerosis and lipid peroxidation products, malondialdehyde (mda) in rabbits. the animals were divided into four groups each comprising 5 rabbits, on the basis of their diets. group i, control diet; group ii, ...	1989	2764311
[our experience in treating peritonitis following cesarean section].	fourteen parturients were admitted and treated in the ward of emergency operative gynecology of the "n. i. pirogov" rnpismp for the period of 1980-1986 in connection with peritonitis after caesarean section. four out of 14 parturients died. the clinical course of peritonitis after caesarean section is changed considerably under present conditions. nontypical symptoms of its course create considerable difficulties in diagnosis and lead to late therapeutic measures, which worsen the outcome of tre ...	2009	2764246
severity of precipitated opiate withdrawal predicts drug dependence by dsm-iii-r criteria.	drug diagnoses in dsm-iii-r are based on the dependence syndrome concept which hypothesizes that dependence on drugs is defined by behavioral and physiological changes but is separate from the social problems related to drug use. previous studies provide support for the dependence syndrome in drug use; however, no study has examined whether biological indications of addiction are related to the dependence syndrome. the present study tests this relationship in 52 opiate addicts who were administe ...	2009	2763981
[of course, one can measure quality of care!].		2009	2763666
multiple pregnancy as a risk factor in rural tanzania.		2009	2763366
[activation of the complement system in dilated cardiomyopathy].	the levels of anaphylatoxins (c3a, c5a) in blood, components of complements c3 and c4, antibodies to cardiolipin, igg, iga, igm, ige and circulating immune complexes were measured in 21 patients with dilated and hypertrophic cardiomyopathy (dcmp and hcmp) and in 11 donors. the mean level of c3a in dcmp patients (572 +/- 55 ng/ml) was significantly higher than in hcmp patients (344 +/- 30 ng/ml) and in donors (294 +/- 43 ng/ml) (p less than 0.001). on comparison of c5a concentrations in dcmp pati ...	2009	2763196
[break with a good examination tradition].		2009	2763101
mri of the mandible.	eighteen patients with abnormalities of the mandible and two normal volunteers were studied with mri. correlation was made with mr, ct, plain x-rays, clinical examination, and surgical findings when possible. in primary tumors of the mandible, mr was able to differentiate between solid and cystic lesions. in the cases of secondary invasion of the mandible by malignant tumors, mr was able to demonstrate replacement of the normal high signal bone marrow by low signal tumor. in some cases, the exte ...	2009	2763009
[amborum special f and asfo--2 glucocorticoid-containing herbal remedies].	amborum special f and asfo are two names of a herbal remedy which is adulterated with the glucocorticoid betamethasone. patients with asthma, rheumatic and chronic diseases import the drug direct from burbank, california, usa. its impressive antiasthmatic effect is reported in two patients. while under therapy the first patient developed cushing's syndrome and the second showed suppression of adrenal cortisol production. the manufacturer, who claims that the drug contains no "western medicine" a ...	2009	2762789
final maturation and ovulation provoked by supply of homologous hypophysis in hoplias m. malabaricus (pisces, erythrinidae).	the final maturation and the ovulation were induced in recently collected specimenes of hoplias m. malabaricus that show oocytes with complete vitellogenesis, by using homologous hypophysis. the hormonal supply was a gradual and positive results were obtained with 9 to 10 hypophysis/kg injected according to 3 different methods. the time of oocytes' maturation from the first dose ranges between 32 and 60 hours a 18 degrees c. the stages of maturation of the oocyte were controlled by intraovaric c ...	2009	2762598
[infection caused by paracoccidioides brasiliensis in people living in cocle and veraguas, republic of panamá].	intradermal application of yeast phase paracoccidioidin antigen obtained by sonication and lysis from the fungus to 111 residents of veraguas province (68 men and 43 women) and 130 cocle province residents (57 men and 73 women) elicited a positive reaction in 9.01% (1/111) and 26.15% (34/30) of the veraguas and cocle residents respectively. positive reactions ranged between papules of 5 and 27 mm in diameter, the majority being between 11 and 20 mm. infection was more frequent in men (1:1.47 for ...	1989	2762594
spectroscopic imaging by dephasing amplitude changing (sidac).	a technique for spectroscopic imaging based on a new concept of dual encoding (i.e., both phase and frequency encoding) of position along the direction of the read-out gradient is proposed. the phase encoding is produced by changing the amplitude of the dephasing gradient as in conventional phase encoding. high-resolution spectroscopic images of a normal human thigh obtained by a 2.0 tesla whole body mr imaging system are presented.	1989	2762582
protein evolution on rugged landscapes.	we analyze a mathematical model of protein evolution in which the evolutionary process is viewed as hill-climbing on a random fitness landscape. in studying the structure of such landscapes, we note that a large number of local optima exist, and we calculate the time and number of mutational changes until a protein gets trapped at a local optimum. such a hill-climbing process may underlie the evolution of antibody molecules by somatic hypermutation.	2008	2762321
aids: not the only infectious killer.		2009	2761978
[methods for preparing patients to vascular surgery. our experience].	a personal series covering two years of vascular surgery involving 58 cases without problems of sepsis has been examined. the modalities employed for preventing wound infections and prosthesis suppuration when it occurred and consisting of showers, antibiotic prophylaxis and shaving are reported. in conclusion it is maintained that a specific, disciplined protocol must be followed in all candidates for prosthesis.	2009	2761719
survey of preclinical medical students: declining interest in becoming a physician.		2009	2761657
influence of alanylglutamine infusion on gastrointestinal glutamine and alanine metabolism in anesthetized dogs.	in this study we administered an infusion of alanylglutamine (10 mumol/kg.min) for 60 minutes to postoperative anaesthetized dogs with catheters placed in the portal and hepatic veins. arterial plasma levels of alanylglutamine were 83 +/- 27 mumol/l 20 minutes after the onset of the infusion and remained constant throughout the infusion period. plasma levels of glutamine and alanine approximately doubled compared with preinfusion levels, indicating a release of these amino acids from the dipepti ...	1989	2761423
[nursing experience through interactions with patients: passing of a patient surrounded by her family members].		2009	2761316
tamoxifen decreases the estradiol induced progesterone receptors by interfering with nuclear estrogen receptor accumulation.	the retention time of the estrogen receptor in the nucleus of target cells after antiestrogen treatment has been shown to be longer than after estradiol. this paper describes the accumulation of nuclear estrogen receptors and the obtention of estrogenic responses (i.e. synthesis of cytosolic progesterone receptors and dna) in the rat uterus after tamoxifen treatment in the presence or absence of estradiol. one-week ovariectomized adult rats were implanted with a silicone elastomer capsule contai ...	1989	2761261
2-bromo- and 16-bromo-estrogens and related compounds: potential inhibitors for both estradiol 2- and 16 alpha-hydroxylases in rat liver microsomes.	kinetic studies of inhibition of estradiol 2- and 16 alpha-hydroxylase activities in male rat liver microsomes with 2-bromoestrogens, 4-bromo-estrone (4-bre1), 16 alpha- and 16 beta-bromoestrones and 16 beta-acetylthioestrone (16-acse1) were carried out. 2-bromoestrogens and 4-bre1 nonspecifically blocked the two enzyme activities in a competitive manner, and 2-bromo-estradiol (2-bre2) was the most potent inhibitor for the two hydroxylases among the 2- and 4-bromo steroids. kinetic data, the app ...	1989	2761259
relationship between concentration and anticonvulsant effect of phenytoin against electroshock-induced seizures in rats: comparison of sampling sites for concentration determinations.	the purpose of this investigation was to determine the optimum sampling site for phenytoin concentration measurements in the context of pharmacodynamic studies of the anticonvulsant effect of phenytoin. determination of drug concentrations in the serum, serum water, brain, and cerebrospinal fluid (csf) of rats as a function of time after iv injection of a 6-mg/kg dose revealed a significant disequilibrium between brain and serum water for 15 min and between csf and serum water for 5 min after in ...	1989	2760817
clinical concentrations of volatile anesthetics reduce depolarization-evoked release of [3h]norepinephrine, but not [3h]acetylcholine, from rat cerebral cortex.	we compared the potencies of halothane, enflurane, and methoxyflurane in producing unconsciousness in vivo and in inhibiting the release of [3h]norepinephrine and [3h]acetylcholine in vitro. rats were anesthetized with various concentrations of each anesthetic, and responsiveness was determined by a hemostat tail pinch. slices of cerebral cortex were equilibrated with similar concentrations of each agent in vitro, and potassium-evoked release of [3h]norepinephrine and [3h]acetylcholine was deter ...	1989	2760627
hypersensitivity myocarditis and hepatitis associated with imipramine and its metabolite, desipramine.	we present two cases of myocarditis and hepatitis with histologic characteristics of hypersensitivity-mediated drug reactions associated with imipramine and its metabolite, desipramine. in one case, death was directly attributed to myocarditis; in the second case, the patient died of an acute myocardial infarct, but myocarditis may have played a contributory role. one patient was taking imipramine, and therapeutic concentrations of imipramine and desipramine were documented in postmortem blood. ...	2009	2760582
protection against infection with vibrio cholerae by passive transfer of monoclonal antibodies to outer membrane antigens.	ten monoclonal antibodies (mabs), produced by hybridomas obtained through the cell fusion of mouse myeloma cells and spleen cells from mice immunized with outer membrane antigens of vibrio cholerae, were mixed with suspensions of v. cholerae and administered orally to infant rabbits. six of these mabs, each one recognizing a different outer membrane antigen, did not confer protection from fatal v. cholerae infection. four mabs that reacted with the 18-kda antigen, also called the cholera protect ...	1989	2760481
survey of fatal anaphylactic reactions to imported fire ant stings. report of the fire ant subcommittee of the american academy of allergy and immunology.	a physician questionnaire survey was conducted by the fire ant subcommittee of the american academy of allergy and immunology to document deaths caused by imported fire ant stings. from the 29,300 physicians surveyed, reports of 83 fatal and two near-fatal fire ant-sting reactions were received. most anaphylactic deaths were reported from florida (22) and texas (19). after excluding duplicate reports, four confirmed deaths were documented in alabama, 10 in florida, two in georgia, two in louisia ...	2009	2760357
denervation of primate extraocular muscle. a unique pattern of structural alterations.	extraocular muscles differ from most other skeletal muscles in terms of constituent fiber types and innervation pattern. the rules that govern fiber responses to various experimental interventions for most skeletal muscles, therefore, may not strictly apply to the extraocular muscles. in this study, denervation of the extraocular muscles of cynomolgous monkeys, macaca fascicularis, was accomplished by intracranial transection of the oculomotor nerve. survival times of 3-167 days were allowed, an ...	1989	2759804
rhinomanometry in children.	during the period january 1982 to december 1985 nasal resistance (nr) was measured by computer-assisted 'head-out' plethysmography in 986 patients aged 4-18 years referred to the airflow laboratory at the hospital for sick children, toronto. nasal resistance was found to decline with increasing age, and it was elevated in the presence of mucosal swelling, adenoid enlargement and other significant nasal pathology. studies of variance on the equipment used indicated that in the assessment of nr re ...	2009	2759778
biological and immunological properties of sugi basic protein-pullulan conjugate. i. suppressive effect on ige antibody production and on ige-mediated reactions.	sugi basic protein (sbp), a major allergen of japanese cedar pollen, conjugated to pullulan acquires suppressive activities for ige, but not for igg antibody production, and for ige-mediated pk reactions in a sbp-specific manner. when either normal or ige anti-sbp antibody-producing mice were treated with the conjugate, ige anti-sbp antibody levels scarcely increased even after immunization with sbp + alum. this suppression was shown to be sbp specific and ige selective. the ability of sbp-pullu ...	1989	2759711
ethnic differences in blood pressure, pulse rate, and related characteristics in young adults. the cardia study.	this study examined ethnic differences in blood pressure and pulse rate in young adults to see whether the differences, if they exist, can be explained by differences in body mass index, lifestyle, psychological, and socioeconomic characteristics. data used were from the baseline examination of the coronary artery risk development in (young) adults study (cardia). cardia is a longitudinal study of lifestyle and evolution of cardiovascular disease risk factors in 5,116 young adults, black and whi ...	2008	2759681
effects of alpha-latrotoxin on the early developmental events of the sea urchin paracentrotus lividus: a histochemical study.	the effects of the spider toxin alpha-latrotoxin (alpha-ltx) on gametes, zygotes, and early embryos of the sea urchin paracentrotus lividus have been investigated by in vivo experiments and by histochemical studies of acetylcholinesterase (ache) activity. treatment of unfertilized eggs with nanomolar amounts (1 to 0.3 nmol/l) of alpha-ltx neither triggered cortical granule exocytosis, nor prevented the elevation of the fertilization layer by sperms. instead, fertilized eggs exposed to alpha-ltx ...	2009	2759409
an optimized synthesis of 18f-labelled 5-fluorouracil and a reevaluation of its use as a prognostic agent.	an optimized synthesis of 18f-labelled 5-fluorouracil (5-fu) is described. the biodynamics of this radiopharmaceutical were studied in nude mice bearing a 5-fu sensitive (colon 38 carcinoma) or a 5-fu resistant (r1-rhabdomyosarcoma) tumour. it was found that not the initial tumour uptake, but the efflux of the 18f activity from the tumour was correlated with the 5-fu sensitivity of the tumour.	2007	2759123
effects of public day-care: a longitudinal study.	119 swedish children were followed from their first year of life up to the age of 8. most could be classified according to (a) type of day-care they had experienced during their first 7 years of life and (b) time of first entrance into day-care. at 8 years, the children were tested with aptitude tests and rated by their teachers on school performance and social and personal development. hierarchical regression analyses and mancovas were used in the statistical treatment. time of entrance into da ...	2009	2758882
intracranial tumors. vomiting as a presenting sign. a gastroenterologist's perspective.	vomiting is seen as a symptom in patients with brain tumors, but it rarely leads to the diagnosis in the absence of a recognized neurologic deficit. five patients were referred to a pediatric gastroenterologist for outpatient evaluation of persistent vomiting and were subsequently found to have an intracranial mass lesion. the paucity of neurologic findings and the absence of headaches in most of these patients caused the referring physicians to focus on the gastrointestinal tract and not the ce ...	2009	2758717
characterization of ion movements and their relationship to muscarinic receptor binding and excitation-contraction coupling in guinea pig ileal longitudinal smooth muscle.	the relationship between ion movements (sodium uptake and potassium release) and agonist-induced contractile responses or muscarinic receptor binding was investigated in the guinea pig ileal longitudinal muscle (gplm). sodium uptake and potassium release were agonist-dependent, concentration-dependent, and stereoselective, with the following rank order of maximum ion movement: muscarinic agonists greater than histamine greater than substance p = serotonin. potassium depolarization did not initia ...	1989	2758375
characterization of ion movements and their relationship to muscarinic receptor binding and excitation-contraction coupling in guinea pig ileal longitudinal smooth muscle.	the relationship between ion movements (sodium uptake and potassium release) and agonist-induced contractile responses or muscarinic receptor binding was investigated in the guinea pig ileal longitudinal muscle (gplm). sodium uptake and potassium release were agonist-dependent, concentration-dependent, and stereoselective, with the following rank order of maximum ion movement: muscarinic agonists greater than histamine greater than substance p = serotonin. potassium depolarization did not initia ...	1989	2758375
[microcomputer-assisted system for photographing the movements of biological valve prostheses].	the aim of the study was to develop a clinically usable system of photographic imaging of the movements of biological valve transplants and of evaluating temporal and spatial relationships. the system has been established by means of a microcomputer and associated peripheral electronic equipment so that there is no need to use a high-speed camera. functioning of the system was verified by testing 37 aortal valve allotransplants and the björk shiley mechanical valve prosthesis.	2009	2758334
age changes in the crystallinity of bone mineral and in the disorder of its crystal.	the crystallinity of bone mineral and disorder of the crystal at different ages were measured by the x-ray diffraction method of ruland. measurements were made on femoral mid-diaphyses of wistar rat from 2 weeks to 1 year of age. for a given animal age, the crystallinity of bone mineral increases with age, while the overall disorder of the crystal does not vary within experimental accuracy. the increase in the crystallinity with age is attributed to an increase in crystallite size, a decrease in ...	1989	2758062
reactive fetal heart rate response to vibroacoustic stimulation in fetuses with low scalp blood ph.	fetal vibroacoustic stimulation in fetuses with suspicious or ominous fetal heart rate traces in labour was followed by acid-base balance determination on fetal scalp blood within 30 min of the test. the mean fetal scalp blood ph values were significantly higher in fetuses that showed reactive responses with fetal heart rate acceleration compared with those who had no response or responded with a deceleration to the vibroacoustic stimulation (ph 7.30 and 7.22 respectively). however, acidotic sca ...	2009	2757982
factor ix kawachinagano: impaired function of the gla-domain caused by attached propeptide region due to substitution of arginine by glutamine at position -4.	factor ix kawachinagano (kwc) is a mutant factor ix protein initially recognized in a patient with severe haemophilia b, who had 46% of normal factor ix antigen and no detectable clotting activity. previous studies indicated that factor ix kwc was not activated by factor xia in the presence of ca ions. in the present study, we purified and analysed factor ix kwc at a structural level in an attempt to clarify the nature of the impaired reaction with factor xia. kinetic studies showed that activat ...	2009	2757966
attempted passive transfer of a serum factor in chronic urticaria from human to monkey.		1989	2757947
differential effects of flurbiprofen and aspirin on acetazolamide disposition in humans.	the plasma concentration-time profile of acetazolamide (az) following an intravenous bolus dose (5 mg kg-1) was determined during control, aspirin and flurbiprofen (flu) treatment periods. the unbound fraction of az in plasma increased three-fold in the presence of salicylate (sa) while, in contrast, flu produced consistent, but statistically insignificant, increases in binding. sa caused a two-fold decrease in both unbound az renal clearance and apparent volume of distribution at steady-state, ...	2009	2757898
reduction of doxorubicin toxicity by methylene blue in cultured rat myocardial cells.		1989	2757653
sex differences in property crime in a danish adoption cohort.	sex differences in genetic and environmental influences on criminal behavior against property were studied in a birth cohort of 6129 male and 7065 female danish adoptees and their biological and adoptive parents. both genetic and environmental factors were found to contribute to variation in liability to property criminality, the relative proportions of variance explained being similar in males and females. important shared- and nonshared-family environmental factors were present. in separate an ...	2008	2757590
perioral anesthesia disrupts maternal behavior during early lactation in long-evans rats.	the role of perioral somatosensory stimulation from pups in maternal behavior was investigated in lactating long-evans rats (rattus norvegicus) during early lactation by local anesthesia of the mystacial pads with lidocaine, which blocks conduction in the infraorbital nerve. it was concluded that (1) acute perioral anesthesia markedly inhibited pup retrieval when the subjects had no formal pretreatment retrieval experience. further, these dams displayed little tolerance to the lidocaine treatmen ...	1989	2757582
grandmultiparity: a continuing problem in developing countries.	four hundred and thirty-one grandmultiparae and 1,070 less parous women who delivered at civil hospital, karachi over a 2-year period (jan. 1982 to dec. 1983) have been reviewed retrospectively. the purpose was to estimate the incidence of grandmultiparity at this hospital and compare the incidence of obstetric and medical complications in the grandmultiparae with the less parous women. a higher incidence of anaemia, spontaneous abortions, abruptio placentae, postpartum haemorrhage, spontaneous ...	2009	2757575
closed endarterectomy. preferred operation for aortoiliac occlusive disease.	closed endarterectomy using the leveen plaque cracker was performed on isolated, clamped segments of the unopened aorta, iliac, and femoral arteries. the results of this type of endarterectomy have been analyzed for 111 patients who were followed up from 2 1/2 to nine years. the five-year patency rate was 99%. after nine years, 96.5% of the vessels that underwent surgery remained functionally and radiographically patent. closed endarterectomy is a substantial improvement over conventional open o ...	2009	2757515
time course of the anticonvulsant action of clonazepam during ontogenesis in the rat.	a time course of the protective action of clonazepam against metrazol-induced seizures was studied in 612 rats aged 7, 12, 18, 25 and 90 days. two doses of clonazepam (0.1 and/or 1 mg/kg) were used and metrazol (100 mg/kg in all but 18-day-old animals where 90 mg/kg were given) was administered s.c. from 30 min to 48 hr. not all time intervals were examined in all age groups. eight to 14 rats were used for each time interval, dose and age group. both doses exhibited a clear-cut antimetrazol acti ...	1989	2757463
assignment of human genes for phosphorylase kinase subunits alpha (phka) to xq12-q13 and beta (phkb) to 16q12-q13.	phosphorylase kinase (phk), the enzyme that activates glycogen phosphorylases in muscle, liver, and other tissues, is composed of four different subunits. recently isolated rabbit muscle cdnas for the larger two subunits, alpha and beta, have been used to map the location of their cognate sequences on human chromosomes. southern blot analysis of rodent x human somatic cell hybrid panels, as well as in situ chromosomal hybridization, have provided evidence of single sites for both genes. the alph ...	1989	2757032
predictive value of a short dietary questionnaire for changes in serum lipids in high-risk utah families.	dietary questionnaires and serum cholesterol, triglycerides, and high-density lipoprotein (hdl) cholesterol determinations were completed for 1239 subjects aged greater than or equal to 20 at each of two separate screenings. the mean time between screenings was 2.5 y. after correcting for potential confounding variables, reduction of a measure of dietary cholesterol and saturated fatty acids assessed by two simple questions was a significant independent predictor of reduction in total cholestero ...	2009	2756916
morbidity of very young infants with and without acute otitis media.	perinatal and other morbidity of 96 consecutive infants with acute otitis media (aom) before the age of 3 months is compared with that of 96 birthday- and sex-matched controls without aom. perinatal problems were found in 57 aom infants and in 38 controls, prematurity and asphyxia being significantly (p less than 0.05) more common in the study group than in the controls. at the time of aom, 51 infants had concurrent illnesses ('colds' excluded) or anomalies, while only 19 controls (p less than 0 ...	2009	2756838
[herpesvirus and acute peripheral facial paresis].		1989	2756590
protective effect of flavonoids on drug-induced hepatotoxicity in vitro.	primary cell cultures of neonatal hepatocytes were used to examine the protective effect of flavonoids in the presence of hepatotoxins. catechin (cat) and silybin (sil) protected the hepatocytes against cell injury produced by erythromycin estolate (ee), amitriptyline (at), nortriptyline (nt), and tert-butylhydroperoxide (tbooh). leakage of lactate dehydrogenase (ldh), aspartate aminotransferase (ast) and alanine aminotransferase (alt), as well as morphological parameters, were used as indices o ...	1989	2756528
the timing of bedtime and waketime decisions in free-running subjects.	twelve "free-running" temporal isolation studies were performed using healthy human subjects aged 20-81 years (4 males, 8 females). circadian rhythms were measured in subjective alertness (using a visual analogue scale technique) and rectal temperature. in all 12 subjects best fitting rhythm period were found to be shorter for rectal temperature (mean = 24.3 hours) than for subjective alertness (mean = 24.8 hours). both rhythms were predictive of bedtime and waketime decisions. bedtime decisions ...	1989	2756079
effects of kynurenic acid and ketamine on neonatal sleep in rats.	kynurenic acid and ketamine are, besides non-specific actions, antagonists of excitatory acidic amino acids in the rat brain. at intraperitoneal doses of 300 mg/kg (1.6 mmol/l) and 5 mg/kg (18 mmol/l), respectively, they are equipotent antagonists of n-methyl-d-aspartate receptors. we studied the acute effects of ketamine and kynurenic acid, at these doses, on sleep patterns of rats during the second and third postnatal weeks with the so called static charge sensitive mattress (scsb). both kynur ...	1989	2755918
uptake of gentamicin in foetal and newborn rats after a single intraperitoneal injection.	the aim of the present investigation has been to examine 1) the placental passage and uptake of gentamicin in foetal rat tissues and 2) uptake and organ distribution of this drug in neonatal rats with special reference to the kidney. after a single intraperitoneal injection of tritium-labelled gentamicin to the mother, we found a rapid passage of radioactivity across the rat placenta, but no pronounced tendency to accumulation in the foetus. after administration of 10 micrograms or 100 mg gentam ...	1989	2755903
challenges to conducting research with children with cancer.		2009	2755865
[clinical results of thermoradiotherapy of locally advanced and recurrent breast cancers--comparison of results with radiotherapy alone].	from august 1979 through january 1988, 23 breast cancer patients with 25 tumors supposed to be refractory to conventional treatment were treated by thermoradiotherapy. of the 25 tumors, 10 were locally advanced primary tumors [group 1], 4 locally advanced recurrent tumors after operation more than 5 cm in maximum diameter [group 2], and 11 locally recurrent tumors after radiotherapy [group 3]. the present study was not a formal randomised-trial, but a historical-controlled study. the results wer ...	2009	2755796
patch clamp experiments on nicotinic acetylcholine receptor-ion channels in bullfrog sympathetic ganglion cells.	nicotinic acetylcholine-receptor ion channels (achr channels) were studied in bullfrog sympathetic ganglion cells cultured for 1 day to 3 weeks, using a patch clamp technique. microsuperfusion of ach (2-10 microm) to the ganglion cell under the whole cell clamp produced an inward current at membrane potentials negative to -60 mv, which had a fast onset and decay. this rapid ach-induced current was accompanied by a large current fluctuation, decreased and increased in amplitude by membrane depola ...	2006	2755769
antiulcer agents. 4. conformational considerations and the antiulcer activity of substituted imidazo[1,2-a]pyridines and related analogues.	definition of the interrelationship between the conformational characteristics of a series of substituted imidazo[1,2-a]pyridines and their antiulcer activity was investigated by examining the conformational properties of 3-cyano-2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine (1), using a variety of experimental and theoretical methods. the results of these studies was the identification of two distinctly different candidates, designated the "folded" and the "extended" conformation, respective ...	1989	2754693
retinal projections to the medial terminal nucleus of the rat with induced unilateral congenital eye defects.	retinal projections, particularly the ipsilateral projections, to the medial terminal nucleus (mtn) of the accessory optic system were investigated by autoradiography in adult rats after being reared in one of three different conditions: (1) normal visual experiences, (2) an application of trypan blue for intrauterine induction of congenital unilateral anophthalmia; and (3) the procedures for intrauterine production of congenital microphthalmia in which both eyes are reduced in size. in congenit ...	1989	2754416
quality-of-life measures.		2005	2754413
reasoning about conditional sentences: development of understanding of cues to quantification.	the previous literature has reported that when children are asked to judge the truth or falsity of universally quantified conditional sentences of the form if a thing is p then it is q they typically give responses, e.g., responding "true" whenever there is a case of p and q even if there are also cases of p and not-q. three experiments are reported that address possible sources of this error. experiment 1 shows that the error survives on sentences that refer to particular things as well as to t ...	2008	2754390
long-acting somatostatin analog controls acid and gastrin secretion in benign, not in malignant, zollinger-ellison syndrome.	the long-acting somatostatin (sms) analog, sms 201-995 has beneficial effects on apudomas. in two zollinger-ellison syndrome (zes) patients we assessed basal acid output (bao) and 24-h ph under sms and compared them to controls. we also assessed total gastrin, gastrin 17, insulin, glucagon, c-peptide, and sms by radioimmunoassay. in the benign gastrinoma, an acid-controlling action of sms was shown, elevating the 24-h ph threshold over the ph range 1.5-5 of 55-10% compared with control. a parall ...	2008	2754214
lipofibroma of the superficial branch of the radial nerve.	lipofibromas of nerve are rare hamartomatous lesions almost exclusively involving the median nerve. to our knowledge, this is the first reported case of a lipofibroma involving a branch of the radial nerve.	2006	2754204
distal interphalangeal joint flexible implant arthroplasty.	twenty-one osteoarthritic distal interphalangeal joints in 13 patients were treated by flexible implant arthroplasty. follow-up to 5 years showed results that were good to excellent, with only one complication, and a high degree of patient satisfaction. the procedure should be considered a good alternative to the more traditional distal interphalangeal joint arthrodesis.	2008	2754198
diagnosis of ganglion in guyon's canal by magnetic resonance imaging.	compression of the ulnar nerve at the wrist can be caused by a multitude of intrinsic and extrinsic factors. the exact diagnosis and location of compression can frequently be difficult to determine. magnetic resonance imaging can be a useful method in diagnosing the cause and location of ulnar nerve compression. a case is presented of ulnar nerve compression caused by a ganglion in guyon's and diagnosed preoperatively by magnetic resonance imaging.	2006	2754196
axonal pathfinding during the regeneration of the goldfish optic pathway.	retinal ganglion cells in fish and amphibians regenerate their axons after transection of the optic nerve. fiber tracing studies during the third month of regeneration show that the axons have reestablished a basically normal fiber order in the two brachia of the optic tract; axons originating in the ventral hemiretina are concentrated in the dorsal brachium, axons from the dorsal hemiretina in the ventral brachium. attardi and sperry (exp. neurol. 7:46-64, 1963) first suggested that the reestab ...	2007	2754027
on the asymmetry of the primary branching of vagal sensory axons: possible role of the supporting tissue.	central and peripheral nonmedullated processes of vagal nodosal neurons of the cat were studied in normal nerves and after regeneration along their anatomical course and along the hypoglossal nerve. nonmedullated fibers above the ganglion and in the root had comparable sizes (approximately 0.37 micron2) and caliber distribution. below the ganglion, the cross-sectional area increased to 1.0 micron2. in axons of equal caliber, supranodosal and radicular fibers had similar microtubular densities wh ...	1989	2754026
staphylococcus aureus strains which are not identified by rapid agglutination methods are of capsular serotype 5.	a total of 183 recent staphylococcus aureus clinical isolates were tested with three commercially available rapid agglutination methods. the capsular polysaccharide type and resistance to oxacillin of these isolates were also determined. seven isolates were not identified correctly by agglutination methods. all isolates not identified by the rapid methods were of capsular serotype 5, and of these isolates, six were resistant to oxacillin. the results suggest that these agglutination kits can be ...	1989	2754004
[assessment of endoscopic embolization in the management of esophageal varices].	between february 1984 and september 1987, endoscopic embolization (ee) was performed in 26 patients with esophageal varices. the effects of ee were evaluated with endoscopic findings according to the general rules for recording endoscopic findings on esophageal varices as specified by the japanese research society for portal hypertension. 1) when the result was regarded as effective if a patient had cw, f1, r-c sign (-), li and lm or disappearance of varices, the improvement was found in 66.7% f ...	2007	2753992
ascorbic acid facilitates chicken myoblast fusion in vitro.	addition of low concentrations of ascorbic acid (5 micrograms/ml to 10 micrograms/ml) to myogenic chick embryo cultures resulted in an early fusion. at 30 h cultures receiving small amounts of ascorbic acid presented fusion rates 3 times that of the control. however, control rates of fusion were not different from those of experimentals at 50 h. no such effect was seen with ascorbic acid added at 24 h of culture, or with ascorbic acid addition to a calcium-deprived system. these findings demonst ...	1989	2753849
duration of inhibition of immediate skin test reactivity by hydroxyzine hydrochloride in dogs.	the duration of hydroxyzine-mediated suppression of the immediate hypersensitivity reaction in the skin of dogs was assessed by intradermal administration of various dilutions of histamine phosphate and of aqueous flea antigen in 18 dogs known to be allergic to fleas. wheal diameters and scores were used to evaluate the strength of the resulting reactions. in most dogs, significant (p less than 0.05) inhibition lasted from 3 to 5 days after withdrawal from treatment. some dogs took up to 9 days ...	1989	2753775
status asthmaticus.		2009	2753556
acridine orange stain--a rapid method for diagnosis of neonatal septicemia.	the present study included 150 newborns; 100 clinically septic and 50 clinically aseptic who served as control. out of 100 clinically septic newborns, blood culture was positive in 33 (33%), serum crp was positive in 64 (64%) and acridine orange stained buffy coat smear was positive in 76 (76%). serum crp was found to be the most specific (specificity 96%) and acridine orange stained buffy coat smear examination the most sensitive (sensitivity 94.3%) test for diagnosis of neonatal septicemia.	2007	2753531
acridine orange stain--a rapid method for diagnosis of neonatal septicemia.	the present study included 150 newborns; 100 clinically septic and 50 clinically aseptic who served as control. out of 100 clinically septic newborns, blood culture was positive in 33 (33%), serum crp was positive in 64 (64%) and acridine orange stained buffy coat smear was positive in 76 (76%). serum crp was found to be the most specific (specificity 96%) and acridine orange stained buffy coat smear examination the most sensitive (sensitivity 94.3%) test for diagnosis of neonatal septicemia.	2007	2753531
you're supposed to feel abnormal.		2009	2753365
hepatic extraction of morphine is impaired in cirrhosis.	using hepatic vein catheterization this study has provided the first direct measurement of morphine hepatic extraction in 8 controls and 8 cirrhotics. the extraction ratio was 0.52 in the control group and was reduced by 25% in the cirrhotics. this reduction is due to impaired enzyme capacity rather than reduced blood flow. the effect of cirrhosis is less than that reported in similar studies of high clearance oxidized drugs and this lends support to the concept that glucuronidation may be relat ...	2009	2753069
mass treatment approach to acute diarrhoeal disease in afabet hospital, northern ethiopia.	during an outbreak of acute diarrhoeal disease in a military camp in afabet region from august to october 1985, 416 cases were admitted to afabet hospital. all were national military service recruitee males who developed signs of moderate to severe dehydration. simplified methods of diagnosing and treating the disease were used so that mass rehydration therapy could be instituted early, using locally available manpower and material resources. the severity of dehydration was graded, and rehydrati ...	2009	2753031
diagnostic utility of echocardiography in ethiopia.	consecutive requests of 1557 echocardiographic studies performed between january 1984 and june 1988 were analysed in order to identify common cardiac abnormalities encountered, the pattern of referral and most important the usefulness of the procedure at our hospital. organic heart disease was found in 1240 patients, of whom 541 (43.6%) had acquired valvular heart disease; 338 (27.4%) congenital heart abnormalities; 154 (12.4%) cardiomyopathies; 139 (11.2%) pericardial disease and 68 (5.4%) othe ...	2009	2753030
exposure level monitor of 3-amino-1,4-dimethyl-5h-pyrido[4,3-b]indole, a dietary carcinogen, in rabbits.	the present investigation describes a method for the detection of minute amounts of 3-amino-1,4-dimethyl-5h-pyrido[4,3-b]indole (trp-p-1), a carcinogenic tryptophan pyrolysate, bound to the hemoglobin of erythrocytes and plasma from rabbits dosed orally with the dietary carcinogen. the method consists of the acid-induced release of the dietary carcinogen adducts as the free carcinogen and their extraction with methylene chloride and subsequent quantitation by high-performance liquid chromatograp ...	1989	2753027
further studies on the role of the gonads in determining the ontogeny of gonadotropin secretion in the guinea pig (cavia porcelus).	to further examine whether nongonadal restraint of gonadotropin secretion during prepubertal development plays a major role in the timing of puberty in the guinea pig, as it does in the monkey and other primates, two experiments were performed. in the first, neonatal male and female guinea pigs were either bilaterally gonadectomized or sham gonadectomized on day 2 of age, or left intact. circulating lh concentrations were measured in blood samples collected by cardiac puncture every 4 days begin ...	1989	2752984
[transplantability and immunogenicity in mice of lymphoma nk/ly cells modified by concanavalin a and neuraminidase].	the modifying effect of con a, vibrio cholerae and non-vibrio cholerae neuraminidase (vcn, nvcn) on the proliferative potential and immunogenicity of experimental lymphoma nk/ly cells is shown in vitro and in vivo. the efficacy of immunization by the modified tumour cells of mice with transplantable lymphoma is evaluated. a considerable decrease in the proliferative potential of transplantability and a moderate increase in immunogenicity of con a treated cells were determined in vitro. the high ...	1989	2752940