Publications

genetic control of the immune response to ferritin in f1 hybrid mice.	the immune response to the antigen horse spleen ferritin, has been investigated in ten inbred parental strains and seven different f1 hybrid strains of mice, using an antigen excess technique. the degree of dominance in an f1 hybrid system can be estimated by using the fisher dominance index. the responses in f1 hybrid animals, obtained from crosses of high and low responder parents, varied from dominant to recessive but the overall mean dominance index for the ferritin immunogenetic system was ...	1977	415964
the influence of the mating system on the maintenance of genetic variability in polygenic characters.	the traditional models of the effect of assortative mating and inbreeding on the genetic variance of polygenic characters (fisher 1918; wright 1921) presume that there is no natural selection or mutation. in a large population, the genetic variance determined by additive genes may then increase by up to a factor of two with local inbreeding, and even more with assortative mating. the classical models are still used to interpret data from natural populations. but contrary to their assumptions, mo ...	1977	407132
an animal model for the study of prostatic adenocarcinoma.	after the injection of the potent carcinogen 9,10-dimethyl-1,2-benzanthracene (dmba) male rats (fisher/furth), mice (strong a/j), and golden hamsters, which had been previously conditioned by castration and in which the prostate had become histologically atrophic, developed tumors consistent with prostatic adenocarcinoma. one month after castration, intravenous injections of dmba were given in the vena cava or jugular vein once a month for 3 months. three to four months later, histologic evidenc ...	1977	406218
analytical characterization of lipopolysaccharide antigens from seven strains of pseudomonas aeruginosa.	lipopolysaccharide antigens from seven different serotype strains (antigen immunotypes nos. 1-7 in the classification of fisher et al.3) of pseudomonas aeruginosa have been analyzed for neutral carbohydrate, amino sugars, lipid, protein, 3-deoxy-manno-octulosonic acid, and phosphorus. the individual amino sugars were determined for each antigen type; all contained 2-amino-2-deoxy-d-glucose and -d-galactose, together with 2-amino-2,6-dideoxygalactose; the latter as isolated from the type 2 antige ...	1977	405103
exotoxin production by clinical isolates of pseudomonas aeruginosa.	seventy-five consecutive clinical pseudomonas aeruginosa isolates were tested for in vitro exotoxin production. exotoxin was demonstrated in culture filtrates biologically, by its ability to produce characteristic dermonecrotic lesions in guinea pigs, and seriologically, by counterimmunoelectrophoresis (cie) with rabbit antiserum elicited with purified exotoxin. by these two methods, exotoxin was detected in 87 and 89% of p. aeruginosa strains, respectively (r = 0.48, p less than 0.001). althoug ...	1977	404244
[effects of methamphetamine and enriched experience on behavioral recovery after brain damage (author's transl)].	two factorial experiments (brain status x environment x drug) were designed to measure the effects of methamphetamine and enriched experience on recovery after bilateral cortical lesions. fisher male rats were operated or sham operated when 30 days old and thereafter raised in either an enriched (ec) or impoverished (ic) condition while daily injected with either methampheteamine (2 mg/kg) or saline. in ec, 12 rats lived together in a large cage with stimulus objects that were changed daily. in ...	1977	403543
selective lymphoid irradiation. i. an approach to transplantation.	the kinetics, distribution, and radiobiologic effects of palladium (pd)-109-hematoporphyrin were determined in the rat. in addition, we studied the effect on rat heart allograft survival of pd-109-hematoporphyrin, with and without antilymphocyte serum (als). a single sublethal dose of pd-109-hematoporphyrin (up to 36 muci/kg) resulted in the following: predominant concentration in lymphoid tissue and proximal bone marrow, complete central and proximal bone marrow ablation with preservation of di ...	1979	380034
corticosteroid therapy of alcoholic hepatitis.	fifty-five patients with alcoholic hepatitis were studied in a 28- to 32-day randomized double blind treatment trial comparing prednisolone (40 mg per day) with placebo therapy. of 31 placebo-treated patients, 4 died during the study interval and 2 more died within 5 days of study completion. only 1 of 24 prednisolone-treated patients died during the same interval (fisher exact test; p = 0.10). stepwise discriminant analysis of laboratory factors associated with death revealed independently sign ...	1978	352788
[role of normal microflora in the treatment of vibrio carrier state in rat gnotobionts].	materials on the study of interactions between vibrio cholera el tor and some indigenous bacteria of human intestinal tract, which proved to be active antagonists in vitro, are presented in this work. experiments were conducted on gnotobiotic rats (fisher), using various combinations and variants of the order of the microorganism administration; there were revealed no antagonistic relations between virbrio cholerae el tor and escherichia coli m-17, lactobacillus fermenti, lactobacillus plantarum ...	1978	352437
the capacity of histocompatibility antigens solubilized in hypertonic salt solution to induce allograft tolerance in rats.	treatment of fisher rats (agb 1,26,28) with a soluble extract of histocompatibility antigens (sae) prepared from the liver of donor august rats (agb 5, 28, 31) associated with a few injections of anti-lymphocyte serum (als) provoked a specific prolongation of the median survival time of skin grafts from 27.6 +/- 11.4 days in als-treated controls to 55.1 +/- 8.8 days (p less than 0.01). the sae was obtained from liver homogenates by hypertonic kcl (3m) extraction. further purification by chromato ...	1978	350127
preliminary observation on the immunology of nerve allograft rejection.	a preliminary experiment was devised to delineate the specificity of nerve allograft rejection. skin grafts were performed between inbred strains of fisher, agb1, and buffalo, agb6, rats to determine the time required for a first set rejection, which occurred at day 9. skin grafts also were performed two weeks after orthotopic placement of whole nerve or fascicular grafts. the rats that had previously been exposed to whole nerve showed skin graft rejection at six days, while those exposed to ner ...	1978	337545
collection of a clean voided urine specimen: a comparison among spoken, written, and computer-based instructions.	in an effort to compare different methods of instructing patients, 99 women 18-25 years of age were given computer, spoken, weitten, or no instructions for the collection of a clean voided urine specimen. the group who received computer instructions was the most uniform in its performance (p less than 0.002, f-test) and reported the fewest procedural problems (p less than 0.02, fisher test). in addition, this group had fewer contaminating bacteria than the group who received written instructions ...	1977	327837
the case of the outspoken medical examiner or an exclusive journal interview with russell s. fisher, md, chief medical examiner of the state of maryland.		1977	321887
ouabain on active transepithelial sodium transport in frog skin: studies with microelectrodes.	studies were done with isolated frog skin to determine the effects of 10(-4) m ouabain on the electrophysiological parameters of outer and inner barriers of the na-transporting cells. microelectrodes were used to impale the skins from the outer surface to determine the intracellular voltages (vsco) under conditions of short-circuiting and under conditions where a voltage clamp was used to vary the transepithelial voltage, vt. from this, the electrical resistances of outer (rfo) and inner (ri) ba ...	1979	314494
[bone marrow lymphoid follicles in myelofibrosis compared with chronic myelogenous leukaemia (author's transl)].	the trephine bone marrow biopsies of 51 patients with myeloproliferative syndromes were revised searching for lymphoid follicles and lymphoplasmocytosis: 18 of these had idiopathic myelofibrosis and 33 chronic myelogenous leukaemia. six of the 18 biopsies on patients with myelofibrosis showed lymphoid follicles but only one of the 33 with chronic meylogenous leukaemia did (p = 0.01, fisher exact test). in addition, four of the six myelofibrosis having follicles had two or more of them. when the ...	1979	296376
error estimate for the diffusion approximation of the wright--fisher model.	the wright--fisher model and its approximating diffusion model are compared in terms of the expected value of a smooth but arbitrary function of nth-generation gene frequency. in the absence of selection, this expectation is shown to differ in the two models by at most a linear combination (with coefficients depending only on the derivatives of the smooth function involved) of the maximum mutation rate and the reciprocal of the population size.	1977	270745
the evolution of dominance: haldane v fisher revisited.	fisher's model for the evolution of dominance indicates that the accumulation of dominance modifiers will be accelerated by (1) an increased frequency of the mutant heterozygote, (2) increased selection for the phenotype of the normal homozygote. the model has been criticised by haldane on the grounds that point (1) is not fulfilled, that is dominance appears to be more common in populations with a low frequency of mutant heterozygotes (populations of inbreeders). in support of fisher's model it ...	1985	268310
dose response and time course effects of n,n-dimethyltryptamine on disruption of rat shuttlebox avoidance.	n,n-dimethyltryptamine (dmt) was given (ip) in different doses (0.25, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg) in a randomized order to a group of ten rats (fisher 344/mai) who were trained to a high, stable base line of conditioned avoidance responding in the shuttlebox. dmt produced dose-dependent disruptive effects, as a sigmoid function, with 1.0 mg/kg the minimal dose causing disruption and progressively more disruption with increasing doses, reaching a plateau at the highest dose. the disruptive eff ...	1977	266950
counselling. hidden conflicts: a case study of the fisher family.		1986	260965
complement in graft versus host disease: il depletion of complement components during a systemic graft versus host reaction in the rat (38499).	serum complement (c) and c components were examined during a systemic graft versus host (gvh) reaction in the rat. in our series of experiments (lewis times brown norway) f-1 hybrid rats (60-80g) were given 200 times 10-6 or 400 times 10-6 lewis spleen cells intravenously. clinical gvh disease appeared 5-7 days after cell injection. five of six rats in the experimental groups had a fall in levels of serum c2 (20-76%) and c4 (75-98%). only one of six rats in the control group had a significant fa ...	1975	236566
apolipoprotein b: its role in the control of fibroblast cholesterol biosynthesis and in the regulation of its own binding to cellular receptors.	apolipoprotein b transports cholesterol in plasma as low density lipoprotein (ldl) and targets its delivery to cells by binding to a specific plasma membrane receptor. the cellular consequences of apob binding to its receptor were investigated to determine whether it suppresses cholesterol biosynthesis and reduces the number of cellular receptors for the apoprotein. upon preincubation of fibroblasts with lipoprotein-deficient medium alone or supplemented with either ldl or apob complexed to bsa ...	1979	226637
experimental hyperlipidemia in rats.	implantation of mtt-f4 tumor, a mammotropic tumor that secretes large quantities of acth, gh and prolactin, into male fisher rats induced the development of hyperlipidemia. free fatty acid, triglyceride and cholesterol levels in the plasma were significantly increased at 31 days after tumor implantation. blood glucose and glycerol levels remained normal, while uric acid concentration in the blood was significantly decreased. the concentrations of the serum lipoproteins were significantly increas ...	1979	224751
development of hyperlipidemia associated with increased lipolytic response of isolated adipose tissue cells following prolonged stimulation by an ectopic pituitary tumor.	implantation of mtt-f4 tumor, a mammotropic tumor that secretes large quantities of acth, gh and prolactin, into male fisher rats induced the development of hyperlipidemia. free fatty acid, triglyceride and cholesterol levels in the plasma were significantly increased at 31 days after tumor implantation. blood glucose and glycerol levels remained normal, while uric acid concentration in the blood was significantly decreased. the lipolytic response of isolated adipose tissue cells to acth was sig ...	1978	217811
[fisher's syndrome. peripheral or central origin (author's transl)].	the syndrome described by m. fisher in 1956 includes ophtalmoplegia, ataxia, and generalized loss of reflexes. it is classically considered to be of peripheral origin and its relation to guillain and barre's syndrome in its mesencephalic form is debatable. the authors review 5 cases and discuss the question of a probable central origin. they base their opinion on the pathognomonic features of these cases and those in the literature, as well as the results of their oculographic and electromyograp ...	1978	214838
growth control in simian virus 40-transformed rat cells: temperature-independent expression of the transformed phenotype in tsa transformants derived by agar selection.	fisher rat fibroblasts (fr 3t3), transformed with the tsa30 mutant of simian virus 40 and selected by colony formation in soft agar, maintained the transformed phenotype at high temperature, whereas most transformants isolated from foci were found to undergo a phenotypic reversion toward the normal state in their saturation density, ability to grow in soft agar, and rate of 2-deoxyglucose transport. the temperature-independent phenotype observed in agar-selected transformants was not due to a re ...	1978	212596
impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats.	a series of neurophysiological experiments was performed on the schaffercommissural system of the hippocampus of aged and young anesthetized fischer rats. the aged fisher rats were previously found to exhibit retention performance deficits. no obvious differences were found between aged and young animals in amplitude, latency, stimulation threshold, or wave forms of typical synaptic responses when these were elicited by control (0.3 hz) stimulation pulses. further, the temporal curves of facilit ...	1978	208716
temperature-sensitive growth regulation in one type of transformed rat cells induced by the tsa mutant of polyoma virus.	a fibroblast line of the 3t3 type with a low saturation density was established from fisher rat embryo cells. after infection with either wild-type or tsa mutant polyoma virus, transformants were isolated and cloned at 33 degrees c on the basis of their ability either to grow as dense foci on plastic in liquid medium (type n) or to form colonies in soft agar (type a). polyoma t antigen was detected in all of the transformed lines. the following growth characteristics were studied for both types ...	1977	201774
endogenous protein kinase inhibitors. purification, characterization, and distribution in different tissues.	a thermostable inhibition of atp-protein phosphotransferase (ec 2.7.1.37) (protein kinase) which is present in crude tissue extracts has been resolved by gel chromatography (sephadex g-100) into two molecular forms. these two forms will be referred to as type i and type ii inhibitor. the type i inhibitor (mr approximately or equal to 24,000) is specific for camp-dependent protein kinase and corresponds to the inhibitor described earlier (walsh, d. a., ashby, c. d., gonzalez, c., calkins, d., fis ...	1977	193848
[guillain barré- polyneuroradiculitis and fisher-syndrome in cytomegalovirus infections (author's transl)].	in seven patients suffering from polyneuroradiculitis of the guillain-barré type and one case of fisher syndrome, a cytomegalovirus infection was found. the elevation of the virus-specific igm-antibodies was confirmed in all cases. the clinical course was severe and acute with respiratory disturbances, but complete remission occurred within 1-4 months. the complement fixing antibodies were highest during the first week of illness, so that further elevations could not be demonstrated, therefore m ...	1976	189727
differential cytology in the diagnosis of astrocytary gliomas. a statistical study using the "t" students-fisher test.	the authors have used the "t" student-fisher test in order to verify the differences between two compared average values. the results show the anatomo-clinical individuality of four main types of astrocytary gliomas; multiform glioblastoma, malignant astrocytoma, protoplasmatic astrocytoma, and fibrillary astrocytoma. the occurrence of significant quantitative differences between these four astrocytary gliomas indicates that the histological diagnosis must be differentially made, because these a ...	2004	183105
fructose-1,6-bisphosphatase from young and adult rats.	fructose-1,6-bisphosphatase (e.c. 3.1.3.11) was purified from the livers of young (69-86 days) and adult (370-386 days) fisher rats. the enzyme preparations were examined for increasing amounts of missynthesized proteins by means of heat-inactivation as well as for differences in regulatory properties. no significant difference with respect to the fraction of rapidly heat-inactivated enzyme or km- and ki-values was found. these results do not support the hypothesis that error accumulation result ...	1976	178710
pancreatic inclusions and its relation to boric acid poisoning: review of the literature and report of a case.	it is known among forensic and pediatric pathologists that the demonstration of pancreatic inclusions is considered to have diagnostic significance in cases of boric acid poisoning. fisher was the first to suggest a causal relationship between the inclusions and boric acid toxicity. valdes-dapena and arey paid particular attention to the pancreatic inclusions in reviewing the literature of cases of boric acid poisoning. they found the inclusions in 6 of the 55 autopsies. this paper describes the ...	1996	178584
pure motor hemiplegia secondary to brain-stem tumour.	'pure motor hemiplegia' is a common stroke syndrome defined by fisher as paralysis of face, arm, and leg on one side, unaccompanied by sensory signs, visual field defect, aphasia, or apractognosia. it occurs almost exclusively in hypertensive patients and carried a good prognosis. we report a case of a normotensive patient in whom pure motor hemiplegia was the presenting feature, not of a cerebrovascular syndrome, but of a pontine glioblastoma. we note that brain-stem tumours may masquerade as b ...	1975	176327
experimental chronic serum sickness in rats. a model of immune complex glomerulonephritis and systemic immune complex deposition.	this article describes a method of immunization that produces chronic serum sickness in rats within a relatively short time. fisher rats, which were immunized subcutaneously three times with bovine serum albumin (bsa) in adjuvant, responded with high titers of antibodies to bsa. 2 weeks after the third subcutaneous immunization, daily increasing amounts of bsa were injected either intraperitoneally or intravenously. when an intravenous dose of 2mg of bsa was reached, the rats were given daily in ...	1979	156700
[bushke-fisher keratoderma of the palms and soles].		2003	154793
ma changes in institutionalized down's syndrome persons: a semi-longitudinal approach.	a semi-longitudinal approach was employed in this partial replication of a larger study of ma changes in institutionalized retarded persons (fisher & zeaman, 1970). curves were fitted to ma data for a down's syndrome group and a group of retarded subjects matched on the basis of initial ma and ca. the findings generally replicated those of the earlier study. specifically, the results of a multiple regression/correlation analysis indicated that the two curves were similar in shape, but differed w ...	1978	147627
[2 cases of arthrogryposis].	the authors report two cases of arthrogryposis in two children of 7 1/2 and 13 years; the diagnostic criteria were those of fisher, combining the joint limitations present since birth in at least two different regions, the absence of progressive neurological involvement, and evident amyotrophy. the different etiopathogenic theories are then discussed: review of the literature concerning cases of myopathic arthrogryposis is not very useful; the twelve cases mentioned in the literature are not hom ...	1977	138180
[quantitative study of serotonin-containing cells in fetal rabbit duodenum].	in order to attempt identification in vitro of parameters involved in the cellular differenciation, it was necessary to possess a standard material with identical content and distribution of serotonin cells; these two properties are investigated in this paper. falck's technic is the only sensitive and specific method in demonstrating serotonin young cells devoid of argentaffinity. from 21, 22, 23 and 25 days old rabbit foetuses, 10 mm length duodenal pieces were treated according to falck and se ...	1975	129233
interaction of bacterial cell wall polymers and rat macrophages.	processing of group a and group d streptococcal cell wall was measured after phagocytosis by normal rat peritoneal cells in tissue culture. group a cell wall was practically non-biodegradable in contrast to group d, which was over 80% degraded by 4-8 days in culture. there was no difference in elimination or degradation of mucopeptide or polysaccharide of group a cell walls. neither antiserum or sensitized lymphocytes affected persistence. macrophages from fisher rats (susceptible to group a cel ...	1975	126561
effect of antithymocyte globulin on islet of langerhans transplantation.	lewis rats were treated with streptozotocin to induce hyperglycemia and glycosuria (400-600 mg/dl). transplantation of approximately 1,000 dissociated islets obtained from collagenase-treated pancreases from 4 donors will promptly correct induced diabetes. functional survival of islet allografts is related to genetic disparity between donor and recipient strains. in the closely matched fisher-to-lewis combination, islets functioned for a mean of 4.2+/-1 days while in the agb-incompatible wistar/ ...	1978	106312
specific neutralization of defective spleen focus-forming virus in friend virus complex by rat antiserum.	the spleen focus-forming virus (sffv), a rapidly transforming, replication-defective virus in friend virus (fv) complex that is readily neutralized by antisera directed against its helper virus, was examined for the presence of sffv-specific antigens. antisera prepared in fisher rats against an sffv-infected fisher rat embryo fibroblast line (sffv-fre) neutralized sffv effectively, but not friend-associated murine leukemia virus (f-mulv) whether the latter was tested alone or was mixed with sffv ...	1979	90172
alpha benzene hexachloride inhibition of aflatoxin b1-induced hepatocellular carcinoma. a preliminary report.	alpha benzene hexachloride protected against the development of liver carcinoma in male albino fisher rats ingesting aflatoxin b1.	1978	81137
john own fisher davies.		1978	76163
[quick's hippuric test - a daison, alliot and fisher colorimetric method].		1977	70552
robert henry fisher smith.		1977	63707
electrophysiological findings in the syndrome of acute ocular muscle palsy with ataxia (fisher syndrome).	4 patients are described with ophthalmoplegia (figs. 1 and 2) and ataxia with acute onset. three of them showed only very slight symptoms of generalized polyneuritis. measurement of sensory nerve conduction velocity (fig. 4, table 2) and determination of vibration sense by an electrical vibrator (fig. 3) proved to be helpful for diagnosis. the ocular emg revealed signs of peripheral denervation in 3 cases. pathological changes of the somatosensory evoked potential (fig. 5) which has been registe ...	1976	62826
cordycepin inhibition of 3-methylcholanthrene-induced transformation in vitro.	cordycepin (3-deoxyadenosine), an inhibitor of poly (a) synthesis, was found to inhibit the induction of the endogenous type "c" rna virus by 5-iodo-2'-deoxyuridine in a line of fisher rat embryo cells (h43) grown in vitro, and when continuously incorporated into the medium at those same concentrations, it was found to protect the cells from transformation by the chemical carcinogen 3-methylcholanthrene.	1975	54927
relative tissue distribution of radioactivity in rats with endocrine "autonomous" breast carcinomas after 3h-,99mtc-, and 64cu-bleomycin.	the localization of 64cu-, 3h-, and 99mtc-labeled bleomycin was studied in tissues of fisher rats bearing an endocrine autonomous breast tumor. the 64cu-bleomycin showed a greater uptake than 3h- and 99mtc-bleomycin in the breast tumor at all time intervals studied, from 2 to 72 hr after the tracer. this same differential uptake was shared by the liver and kidney.	1975	45938
the measurement of the adhesion of film coatings to tablet surfaces: the effect of tablet porosity, surface roughness and film thickness.	the effect of tablet porosity, surface roughness and film thickness on the adhesion of hydroxypropyl methyl cellulose films to placebo tablet substrates have been studied using a specially designed tensile tester (fisher & rowe, 4976). there were direct relations between measured adhesion and tablet porosity and also surface roughness and tablet porosity. the effect of film thickness on the measured adhesion is complex with an initial decrease with thicknesses up to 35 micron and then a gradual ...	1999	26762
the adhesion of film coatings to tablet surfaces--the effect of some direct compression excipients and lubricants.	the effect of some direct compression excipients and lubricants on the adhesion of hydroxypropyl methyl cellulose films has been examined using a specially designed tensile testing apparatus (fisher & rowe, 1976). the adhesion was found to be influenced by both the roughness, including microporosity, of the tablet surface and its polarity. tablets prepared from microcrystalline cellulose showed very high adhesions despite having relatively smooth surfaces, owing to the surface being saturated wi ...	1998	22617