Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| epstein-barr virus-positive posttransplant lymphoproliferative disease after solid organ transplantation: pathogenesis, clinical manifestations, diagnosis, and management. | posttransplant lymphoproliferative disease (ptld) is a potentially fatal complication after (solid organ) transplantation, which is highly associated with epstein-barr virus (ebv). the ebv-specific cytotoxic t cell response that is essential in controlling the virus in healthy individuals is suppressed in transplant recipients using immunosuppressive drugs. a primary ebv infection in ebv-seronegative patients receiving an ebv-seropositive donor organ or a reactivation in those who are already la ... | 2016 | 27500242 |
| hla associations and risk of posttransplant lymphoproliferative disorder in a danish population-based cohort. | posttransplant lymphoproliferative disorder (ptld) is a feared complication to organ transplantation, associated with substantial morbidity and inferior survival. risk factors for ptld include t cell-depleting induction therapy and primary infection or reactivation of epstein-barr virus. possible associations between certain hla types and the risk of developing ptld have been reported by other investigators; however, results are conflicting. | 2015 | 27500227 |
| cd30+ primary cutaneous post-transplant lymphoproliferative disorder with signet-ring cell features. | we report a case of primary cutaneous cd30+ post-transplant lymphoproliferative disorder with an uncommon finding of signet ring cell features in a heart transplant patient. the neoplastic cells were cd4 and cd30 positive, and negative for s-100, pancytokeratin, myeloperoxidase, and cd56. in situ hybridization for epstein barr virus (ebv) was negative, even though the patient did have ebv viremia. | 2016 | 27499836 |
| the influence of human papillomavirus on nasopharyngeal carcinoma in japan. | although japan is a non-endemic area with nasopharyngeal carcinoma (npc), the proportion of who type i npc in japan are different from that in non-endemic areas such as north america and europe. recently, it is said that not only epstein-barr virus (ebv) but also human papillomavirus (hpv) has an influence on npc in non-endemic areas. the aim of this study is to clarify the influence of hpv on npc in japan. | 2017 | 27499435 |
| herpes and alzheimer's disease: subversion in the central nervous system and how it might be halted. | the last 8 or so years have seen a large increase in the number of studies supporting the concept of a major role for herpes simplex virus type 1 (hsv1) in alzheimer's disease (ad). the main advances have been made through studies in humans and in mice, investigating the likelihood of reactivation of the latent virus in brain. others have aimed to explain the mechanisms in cells whereby the increase in amyloid-beta (aβ) production on hsv1 infection of cells and mouse brains occurs, and the reaso ... | 2016 | 27497484 |
| hodgkin lymphoma: pathology and biology. | the hodgkin and reed-sternberg (hrs) tumor cells of classical hodgkin lymphoma (hl), as well as the lymphocyte predominant (lp) cells of nodular lymphocyte predominant hl (nlphl), are derived from mature b cells. however, hrs cells have largely lost their b-cell phenotype and show a very unusual expression of many markers of other hematopoietic cell lineages, which aids in the differential diagnosis between classical hl (chl) and nlphl and distinguishes chl from all other hematopoietic malignanc ... | 2016 | 27496304 |
| fulminant epstein-barr virus-associated hemophagocytic syndrome in a renal transplant patient and review of the literature. | we describe a rare fulminant case of epstein-barr virus-associated hemophagocytic syndrome (hps) in a 37-year-old female renal transplant patient, indistinguishable from severe sepsis clinically and in the laboratory. hps involves rapidly escalating immune system activation, resulting in a cytokine cascade, which can, especially in immunocompromised patients, lead to multi-organ failure, and even death. thirty-two herpesviridae-associated hps cases in renal transplant patients have been reported ... | 2016 | 27496079 |
| early diagnosis and follow-up of chronic active epstein-barr-virus-associated cardiovascular complications with cardiovascular magnetic resonance imaging: a case report. | chronic active epstein-barr virus (ebv) infection (caebv) is characterized as chronic or recurrent mononucleosis-like symptoms and elevated ebv deoxyribonucleic acid (ebv-dna) copies. cardiovascular complications have high morbidity and mortality. the treatment regimen for caebv has not been established yet, resulting in poor prognoses. herein, we present a case of cardiovascular magnetic resonance imaging (cmri) evaluation with a series of sequences for caebv-associated cardiovascular involveme ... | 2016 | 27495050 |
| extranodal nk/t cell lymphoma causing cardiorespiratory failure. | extranodal nk/t cell lymphoma is an uncommon malignancy usually involving the sinonasal area. we report an unusual case of extranodal nk/t cell lymphoma diagnosed in a 62-year-old caucasian male who died of progressive cardiorespiratory failure but had no clinically detectable upper respiratory system lesions. the initial diagnosis was made cytologically on a sample of pericardial fluid that contained neoplastic lymphoid cells. these cells were positive for cd2, cytoplasmic cd3, and epstein-barr ... | 2016 | 27493813 |
| etiology and clinical pattern of cervical lymphadenopathy in sudanese children. | cervical lymphadenopathy (cla) is a common childhood problem in clinical practice which poses diagnostic difficulties to pediatricians. the aims of this study were to determine the causes of cla in sudanese children and to evaluate the value of routine laboratory tests in determining the etiology. demographic and clinical data were prospectively collected from eighty children with palpable cervical nodes. children were then subjected to complete blood count, esr, mantoux test, aspiration cytolog ... | 2012 | 27493336 |
| x-linked inhibitor of apoptosis complicated by granulomatous lymphocytic interstitial lung disease (glild) and granulomatous hepatitis. | the x-linked inhibitor of apoptosis (xiap) deficiency is a primary immunodeficiency characterized by epstein-barr virus (ebv)-driven hemophagocytic lymphohistiocytosis (hlh), splenomegaly, and colitis. here, we present, for the first time, granulomatous hepatitis and granulomatous and lymphocytic interstitial lung disease (glild) as manifestations of xiap deficiency. we report successful treatment of glild in xiap deficiency with rituximab and azathioprine and discuss the role of xiap deficiency ... | 2016 | 27492372 |
| lymphoma secondary to congenital and acquired immunodeficiency syndromes at a turkish pediatric oncology center. | the prevalence of lymphoma in primary immunodeficiency cases and autoimmune diseases, as well as on a background of immunodeficiency following organ transplants, is increasing. the lymphoma treatment success rate is known to be a low prognosis. our study aimed to emphasize the low survival rates in immunodeficient vs. immunocompetent lymphoma patients and also to investigate the effect of rituximab in patients with ataxia telangiectasia and other immunodeficiencies. we summarized the clinical ch ... | 2016 | 27492260 |
| [errors in diagnosis and treatment of immunodependent pathology (original concept)]. | based on many years of experience in 2009, we developed the original concept of a mixed approach to the treatment of infectious diseases in patients. during 2.5 years(from 2013 to june 2015) to have applied for consultative-diagnostic help of 3965 patients who had not verified the primary diagnosis. the basic principle of verification of the pathology of the removal of various causes immunosuppression. based on our extensive, research and observation was often found in patients ascaridosis (55%) ... | 2016 | 27491144 |
| myc activation and bcl2l11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs. | lymphomagenesis in the presence of deregulated myc requires suppression of myc-driven apoptosis, often through downregulation of the pro-apoptotic bcl2l11 gene (bim). transcription factors (ebnas) encoded by the lymphoma-associated epstein-barr virus (ebv) activate myc and silence bcl2l11. we show that the ebna2 transactivator activates multiple myc enhancers and reconfigures the myc locus to increase upstream and decrease downstream enhancer-promoter interactions. ebna2 recruits the brg1 atpase ... | 2016 | 27490482 |
| a clinicopathological study of primary central nervous system lymphomas & their association with epstein-barr virus. | primary central nervous system lymphomas (pcnsls) are relatively uncommon, accounting for 2-3 per cent of primary brain tumours. majority of these are diffuse large b cell lymphomas (dlbcl) occurring both in immunocompromised and immunocompetent patients. we undertook this study to classify pcnsl into germinal centre (gc) and non-germinal centre (ngc) type based on hans classification and to find the role of epstein-barr virus (ebv) in pathogenesis both by conventional immunohistochemistry (ihc) ... | 2016 | 27488004 |
| cxcr5(+) follicular cytotoxic t cells control viral infection in b cell follicles. | during unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types, such as human immunodeficiency virus (hiv), which persists in follicular helper t cells (tfh cells), and epstein-barr virus (ebv), which persists in b cells. here we identified a specialized group of cytotoxic t cells (tc cells) that expressed the chemokine receptor cxcr5, selectively entered b cell follicles and eradicated infected tfh cells and b cells. the differ ... | 2016 | 27487330 |
| herpesvirus respiratory infections in immunocompromised patients: epidemiology, management, and outcomes. | among immunocompromised individuals, members of the human herpesviridae family are frequently encountered pathogens. cytomegalovirus, herpes simplex virus 1 and 2, varicella zoster virus, epstein-barr virus, and human herpesvirus-6, -7, and -8 all establish latency after infection and can reactivate during periods of immunosuppression, leading to both direct and indirect adverse effects on the host including severe organ dysfunction as well as allograft rejection and loss after transplantation. ... | 2016 | 27486740 |
| ablation of stat3 in the b cell compartment restricts gammaherpesvirus latency in vivo. | a challenging property of gammaherpesviruses is their ability to establish lifelong persistence. the establishment of latency in b cells is thought to involve active virus engagement of host signaling pathways. pathogenic effects of these viruses during latency or following reactivation can be devastating to the host. many cancers, including those associated with members of the gammaherpesvirus family, kaposi's sarcoma-associated herpesvirus and epstein-barr virus, express elevated levels of act ... | 2016 | 27486189 |
| active cmv and ebv infections in renal transplant recipients with unexplained fever and elevated serum creatinine. | proper identification of active cytomegalovirus (cmv) and epstein-barr virus (ebv) infections are helpful for monitoring antiviral treatment in transplant recipients. qualitative and quantitative cmv, ebv dna pcr techniques in the context of serological tests are performed for early detection and differentiation of active and latent cmv and ebv infections in renal transplantation. basically, 129 renal transplanted recipients monitored carefully and hospitalized for unexplained elevated creatinin ... | 2016 | 27484706 |
| rapid reconstitution of cd4 t cells and nk cells protects against cmv-reactivation after allogeneic stem cell transplantation. | epstein-barr virus and cytomegalovirus reactivations frequently occur after allogeneic stem cell transplantation (sct). | 2016 | 27484705 |
| brincidofovir clearance of acyclovir-resistant herpes simplex virus-1 and adenovirus infection after stem cell transplantation. | infections with adenovirus (adv) and herpesviruses can result in considerable morbidity and mortality in pediatric hematopoietic stem cell transplant (sct) recipients. herpes simplex virus (hsv) reactivations are usually prevented by acyclovir (acv) prophylaxis, whereas cidofovir (cdv) has been used off indication to manage adv infections. we report a child with myelodysplastic syndrome undergoing multiple sct, who experienced hsv-1 disease including severe mucositis and herpetic whitlow, as wel ... | 2016 | 27482652 |
| epstein-barr virus infection and opisthorchiasis: a story of cholangiocarcinoma in the highly endemic area. | 2016 | 27482325 | |
| oral environment and cancer. | cancer is now the leading cause of death in japan. a rapid increase in cancer mortality is expected as japan is facing a super-aged society. many causes of cancer are known to be closely linked to life style factors, such as smoking, drinking, and diet. the oral environment is known to be involved in the pathogenesis and development of various diseases such as bronchitis, pneumonia, diabetes, heart disease, and dementia. because the oral cavity acts as the bodily entrance for air and food, it is ... | 2016 | 27482300 |
| [clinical features and prognosis of cd20-positive classical hodgkin lymphoma]. | to explore the clinical characteristics and prognosis of cd20-positive classical hodgkin lymphoma (chl). | 2016 | 27480653 |
| [an analysis of risk factors and prognosis of epstein-barr virus infection after allogeneic hematopoietic stem cell transplantation]. | to analyze the incidence of epstein-barr virus (ebv) infection in patients after allogeneic hematopoietic stem cell transplantation (hsct), and investigate its risk factors and prognosis. | 2016 | 27480556 |
| quantification of total and 2-ltr (long terminal repeat) hiv dna, hiv rna and herpesvirus dna in pbmcs. | almost all individuals infected with human immunodeficiency virus (hiv) are also infected with cytomegalovirus (cmv) and epstein barr virus (ebv). the aims of our studies have included characterizing and measuring the latent hiv reservoir and understanding the association between asymptomatic replication of cmv (and other herpesvirus, including ebv) and this hiv reservoir (gianella et al., 2014). this protocol was designed to simultaneously co-extract dna and rna from the same peripheral blood m ... | 2015 | 27478862 |
| the safety and immunological effects of rad5-ebv-lmp2 vaccine in nasopharyngeal carcinoma patients: a phase i clinical trial and two-year follow-up. | epstein-barr virus (ebv)-encoded latent membrane protein 2 (lmp2) promotes nasopharyngeal carcinoma (npc) progression. previously, we reported that the dendritic cells (dcs) transfected with ebv-lmp2 recombinant serotype 5 adenoviruses (rad5) induced anti-tumor effect by eliciting cytotoxic t lymphocytes (ctls)-mediated immune response in vitro and the adenoviral vaccine of ebv-lmp2 (rad5-ebv-lmp2) stimulated antigen-specific cellular immunity in mice. however, the safety and immunological effec ... | 2016 | 27477649 |
| spleen tyrosine kinase: a crucial player and potential therapeutic target in renal disease. | spleen tyrosine kinase (syk), a 72 kda cytoplasmic non-receptor protein-tyrosine kinase, plays an important role in signal transduction in a variety of cell types. ever since its discovery in the early 1990s, there has been accumulating evidence to suggest a pathogenic role of syk in various allergic disorders, autoimmune diseases and malignancies. additionally, there is emerging data from both pre-clinical and clinical studies that syk is implicated in the pathogenesis of proliferative glomerul ... | 2016 | 27476075 |
| the multiple faces of nervous system lymphoma. atypical magnetic resonance imaging features and contribution of the advanced imaging. | primary central nervous system lymphoma (pcnsl) is an uncommon variant of extranodal non-hodgkin lymphoma, which involves the brain, leptomeninges, eyes, or spinal cord without evidence of systemic disease. in addition to a detailed history and physical examination, the evaluation of patients suspected of having a pcnsl should include a contrast-enhanced magnetic resonance imaging. occassionaly, pcnsl shows peculiarities on magnetic resonance imaging, which delay the diagnosis and thus the start ... | 2017 | 27475832 |
| chromatin remodeling factor lsh affects fumarate hydratase as a cancer driver. | cancer metabolism and epigenetic alteration are two critical mechanisms for tumorigenesis and cancer progression; however, the dynamic interplay between them remains poorly understood. as reported in the article entitled "chromatin remodeling factor lsh drives cancer progression by suppressing the activity of fumarate hydratase," which was recently published in cancer research, our group examined the physiological role of lymphocyte-specific helicase (lsh) in nasopharyngeal carcinoma (npc) by fo ... | 2016 | 27473869 |
| prognostic value of neoadjuvant chemotherapy in locoregionally advanced nasopharyngeal carcinoma with low pre-treatment epstein-barr virus dna: a propensity-matched analysis. | the aim of this study is to investigate the prognostic value of neoadjuvant chemotherapy (nct) in locoregionally advanced nasopharyngeal carcinoma (npc) with low pre-treatment epstein-barr virus (ebv) dna in the era of intensity-modulated radiotherapy (imrt). | 2016 | 27471562 |
| direct versus sequential immunoglobulin switch in allergy and antiviral responses. | allergy is characterized by ige production to innocuous antigens. the question whether the switch to ige synthesis occurs via direct or sequential pathways is still unresolved. the aim of this work was to analyze the distribution of immunoglobulins (ig) to house dust mite d. farinae and a. alternata fungus in allergic children with primarily established diagnosis and compare it to epstein-barr antiviral (ebv) response in the same patients. in allergy patients the only significant difference was ... | 2016 | 27471213 |
| computational discovery of epstein-barr virus targeted human genes and signalling pathways. | epstein-barr virus (ebv) plays important roles in the origin and the progression of human carcinomas, e.g. diffuse large b cell tumors, t cell lymphomas, etc. discovering ebv targeted human genes and signaling pathways is vital to understand ebv tumorigenesis. in this study we propose a noise-tolerant homolog knowledge transfer method to reconstruct functional protein-protein interactions (ppi) networks between epstein-barr virus and homo sapiens. the training set is augmented via homolog instan ... | 2016 | 27470517 |
| global burden of cancers attributable to infections in 2012: a synthetic analysis. | infections with certain viruses, bacteria, and parasites are strong risk factors for specific cancers. as new cancer statistics and epidemiological findings have accumulated in the past 5 years, we aimed to assess the causal involvement of the main carcinogenic agents in different cancer types for the year 2012. | 2016 | 27470177 |
| beyond epstein-barr virus: genetic predisposition of natural killer t-cell lymphoma. | 2016 | 27470080 | |
| genetic risk of extranodal natural killer t-cell lymphoma: a genome-wide association study. | extranodal natural killer t-cell lymphoma (nktcl), nasal type, is a rare and aggressive malignancy that occurs predominantly in asian and latin american populations. although epstein-barr virus infection is a known risk factor, other risk factors and the pathogenesis of nktcl are not well understood. we aimed to identify common genetic variants affecting individual risk of nktcl. | 2016 | 27470079 |
| diagnostic value of serum epstein-barr virus capsid antigen-iga for nasopharyngeal carcinoma: a meta-analysis based on 21 studies. | epstein-barr virus capsid antigen immunoglobulin a (ebv vca-iga) exerts an important role in the diagnosis of nasopharyngeal carcinoma (npc). this meta-analysis aimed to evaluate the pooled diagnostic performance of vca-iga for npc. | 2016 | 27468579 |
| an early b cell line with a variant 11;19 translocation. | a cell line (bs) carrying a variant 11;19 translocation was established following exposure to epstein-barr virus (ebv) of the blast cells from an infant with null (b precursor) acute lymphoblastic leukaemia (all). morphology, cytochemistry and immunophenotype were identical to those of the original leukaemic blasts and characteristic of an early b cell neoplasm. both the cell line and the patient's blasts had an identical karyotype, 46.xy, t(11;19) (q23;p13), t(11;19)(q13;q13). immunoglobulin he ... | 1991 | 27467674 |
| serum antibodies to cytoskeletal systems in patients with adult t-cell leukemia and healthy htlv-1 carriers. | serum antibodies to cytoskeletal systems were detected, using indirect immunofluorescence in patients with adult t-cell leukemia (atl), healthy carriers of human t cell lymphotropic virus 1 (htlv-1), patients with infectious mononucleosis and healthy adults. healthy carriers of htlv-1 had igg antibodies to cytoskeletal systems as evidenced by an increased incidence of igg antibodies to actin and vimentin. decreased igg antibody levels to epstein-barr virus nucleic acid (ebna) were also evident. ... | 1991 | 27467671 |
| analysis of htlv-i in hodgkin's disease. | both epstein-barr virus (ebv) and the human t-cell leukemia virus i (htlv-i) have been implicated in the generation of human lymphoproliferative disorders such as burkitt's lymphoma, hodgkin's disease (hd) and acute t-cell leukemia (atl). in hodgkin's disease ebv has been recently detected in hodgkin's and sternberg-reed cells in about 20% of the cases. we analysed if htlv-i is also involved in hodgkin's disease by using northern blot analysis and the polymerase chain reaction (pcr). in our expe ... | 1991 | 27467670 |
| the ubiquitin ligase itch and ubiquitination regulate bfrf1-mediated nuclear envelope modification for epstein-barr virus maturation. | the cellular endosomal sorting complex required for transport (escrt) was recently found to mediate important morphogenesis processes at the nuclear envelope (ne). we previously showed that the epstein-barr virus (ebv) bfrf1 protein recruits the escrt-associated protein alix to modulate ne structure and promote ebv nuclear egress. here, we uncover new cellular factors and mechanisms involved in this process. bfrf1-induced ne vesicles are similar to those observed following ebv reactivation. bfrf ... | 2016 | 27466427 |
| nuclear innate immune dna sensor ifi16 is degraded during lytic reactivation of kaposi's sarcoma-associated herpesvirus (kshv): role of ifi16 in maintenance of kshv latency. | ifi16 (interferon gamma-inducible protein 16) recognizes nuclear episomal herpesvirus (kaposi's sarcoma-associated herpesvirus [kshv], epstein-barr virus [ebv], and herpes simplex virus 1 [hsv-1]) genomes and induces the inflammasome and interferon beta responses. it also acts as a lytic replication restriction factor and inhibits viral dna replication (human cytomegalovirus [hcmv] and human papillomavirus [hpv]) and transcription (hsv-1, hcmv, and hpv) through epigenetic modifications of the vi ... | 2016 | 27466416 |
| primary extramedullary plasmacytoma in the gastroduodenal canal associated with epstein-barr virus-associated adenocarcinoma of the stomach: a case report. | the coexistent occurrence of a lymphoid neoplasm with adenocarcinoma of the stomach is rare. we report herein a case of gastroduodenal extramedullary plasmacytoma simultaneously complicated by multiple gastric epstein-barr virus (ebv)-associated adenocarcinomas. the patient underwent distal gastrectomy to treat an adenocarcinoma occupying the gastric antrum. histopathological examination revealed a massive submucosal plasma cell proliferation adjacent to the adenocarcinoma involving the pylorus ... | 2016 | 27466321 |
| programmed death-ligand 1 expression is common in gastric cancer associated with epstein-barr virus or microsatellite instability. | blockade of the programmed death 1 (pd-1) pathway has emerged as a novel therapy for cancer. therefore, development of biomarkers for response prediction, such as pd-ligand 1 (pd-l1) expression by immunohistochemistry, may help to stratify patients. solid tumors with cd8 t-cell rich tumor microenvironment have been implicated to be associated with increased pd-l1 expression. we hypothesized that gastric cancers associated with epstein-barr virus infection (ebv+) or microsatellite instability (ms ... | 2016 | 27465786 |
| epstein-barr virus gene expression in lymphoproliferative disease. | epstein-barr virus (ebv) is associated with burkitt lymphoma, nasopharyngeal carcinoma, and lymphoprolifcrative disease in patients with congenital or acquired immunodeficiencies. b lymphocytes in tissues from these patients often contain ebv genomes. expression of the ebv genes ebna-1, ebna-2, and lmp and the b cell genes cd23, icam-1, and lfa-3 has been demonstrated in lymphoblastoid cells in vitro and in b lymphocytes in tissues from patients with lymphoproliferative disease. in contrast, b c ... | 1991 | 27464244 |
| human herpesvirus multiplex ddpcr detection in brain tissue from low- and high-grade astrocytoma cases and controls. | glioblastoma (gbm) is a fatal cns malignancy, representing 50 % of all gliomas with approximately 12-18 months survival time after initial diagnosis. recently, the human herpesvirus cytomegalovirus (cmv) has been suggested to have an oncogenic role, yet this association remains controversial. in addition, human herpesvirus 6 (hhv-6) and epstein-barr virus (ebv) have also been associated with low-grade gliomas, but few studies have examined hhv-6 and ebv in glioblastomas. droplet digital pcr (ddp ... | 2016 | 27462365 |
| concurrent gastric adenocarcinoma of fundic gland type and carcinoma with lymphoid stroma: a rare case report. | both gastric adenocarcinoma of fundic gland type (adc-fg) and carcinoma with lymphoid stroma (lymphoepithelioma-like carcinoma, lelc) are relatively rare. epstein-barr virus (ebv) has been implicated in the pathogenesis of lelc. however, the pathogenesis of adc-fg, as well as the role of ebv in the carcinogenesis of lelc, remain unclear and under debate. the current study presents a case of concurrent adc-fg and lelc in the stomach in a 69-year-old man. total gastrectomy was performed, and two s ... | 2017 | 27462199 |
| a collaborative study to establish the 1st who international standard for epstein-barr virus for nucleic acid amplification techniques. | variability in viral load measurements using nucleic acid amplification techniques (nat) has a significant impact on the management of epstein-barr virus (ebv)-associated diseases, and has highlighted a need for standardisation of these measurements. the aim of this collaborative study was to evaluate the suitability of a range of candidate reference materials to harmonise ebv viral load measurements in a wide range of nat assays. candidate materials included lyophilised and liquid whole virus p ... | 2016 | 27461128 |
| novel hdad/ebv reprogramming vector and highly efficient ad/crispr-cas sickle cell disease gene correction. | crispr/cas enhanced correction of the sickle cell disease (scd) genetic defect in patient-specific induced pluripotent stem cells (ipscs) provides a potential gene therapy for this debilitating disease. an advantage of this approach is that corrected ipscs that are free of off-target modifications can be identified before differentiating the cells into hematopoietic progenitors for transplantation. in order for this approach to be practical, ipsc generation must be rapid and efficient. therefore ... | 2016 | 27460639 |
| pediatric miller fisher syndrome complicating an epstein-barr virus infection. | miller fisher syndrome, a variant of guillain-barré syndrome, is an acute inflammatory demyelinating polyradiculoneuropathy that may occur weeks after a bacterial or viral infection. campylobacter jejuni and haemophilus influenzae are frequently reported etiological agents. | 2016 | 27460528 |
| epidemiology of major neurodegenerative diseases in women: contribution of the nurses' health study. | to review the contribution of the nurses' health study (nhs) to identifying the role of lifestyle, diet, and genetic or biological factors in several neurodegenerative diseases, including cognitive decline, multiple sclerosis, parkinson's disease, and amyotrophic lateral sclerosis. | 2016 | 27459462 |
| peripheral blood epstein-barr viral nucleic acid surveillance as a marker for posttransplant cancer risk. | several viruses, such as epstein-barr virus, are now known to be associated with several human cancers, but not all patients with these viral infections develop cancer. in transplantation, such viruses often have a prolonged time gap from infection to cancer development, and many are preceded by a period of circulating and detectable nucleic acids in the peripheral blood compartment. the interpretation of a viral load as a measure of posttransplant risk of developing cancer depends on the virus, ... | 2017 | 27458691 |
| a central role for stat3 in gammaherpesvirus-life cycle and -diseases. | having co-evolved with humans, herpesviruses have adapted to exploit the host molecular machinery to ensure viral persistence. the cellular protein signal transducer and activator of transcription 3 (stat3) is a leading example. stat3 is a prominent transcription factor that functions in a variety of physiologic processes including embryonic development, inflammation, immunity, and wound healing. generally activated via growth factor and cytokine signaling, stat3 can transcriptionally drive onco ... | 2016 | 27458446 |
| epstein-barr virus and regulatory t cells in egyptian paediatric patients with acute b lymphoblastic leukaemia. | acute b lymphoblastic leukaemia (b-all) is the most common type of childhood malignancy worldwide but little is known of its origin. recently, many studies showed both a high incidence of epstein-barr virus (ebv) infection and high levels of cd4(+)cd25(+)foxp3(+)(treg cells) in children with b-all. in our study, we investigated the possible relationship between ebv infection and the onset of b-all, and its relation to expression of cd4(+), cd25(high+)foxp3+ t regulatory cells. | 2017 | 27458150 |
| polyclonal bence jones proteinuria associated with reactive plasmacytosis. | a 43 year old black male patient presented with progressive respiratory symptoms, fever and malaise of short duration accompanied by mild epistaxis. physical examination revealed generalised lymphadenopathy and hepatosplenomegaly. peripheral blood examination showed a striking plasmacytosis. further investigation revealed bence jones proteinuria consisting of both kappa and lambda light chains. there was no monoclonal peak on serum electrophoresis and cytoplasmic immunoglobulin and gene rearrang ... | 1990 | 27457302 |
| clinical features and treatment outcome of epstein-barr virus-positive nodal t-cell lymphoma. | the classification of mature nk-/t-cell lymphoma mainly originating from the t-cell lineage with predominantly nodal involvement and epstein-barr virus (ebv) positivity in a majority of tumor cells is unresolved. we analyzed the clinical features and treatment outcomes of such patients. five patients with ebv-positive nodal t-cell lymphoma were surveyed during follow-up period. the median age was 53 years (range 33-88 years), and all patients showed nodal involvement. the patients mostly present ... | 2016 | 27456462 |
| peptide based viral detection systems for effective diagnosis of common viral infections in india. | accurate and swift detection of viruses causing diseases in humans represent continuous challenges to diagnostic and epidemiological research. efficient and rapid diagnosis is also crucial for effective implication of diseases management strategies. multitude approaches attempted to identify individual viruses, includes serological assays and molecular methods. detection assays based on peptides have become increasingly substantial and indispensable for its advantages over conventional methods. ... | 2016 | 27455967 |
| considerations on risk factors correlated to the occurrence of gastric stump cancer. | gastric stump cancer (gsc) is the malignant tumor that develops in the gastric remnant after partial gastrectomy was performed both for benign and malignant lesions. this paper presents the results of the case studies from the scientific literature, which focused on gsc, and has been published in the last 10 years. the search was performed with the help of the specific tools offered by the international databases. the subject was approached because of the constant rising incidence of gsc in the ... | 2017 | 27453741 |
| [transformation of patient-derived tumor xenografts into lymphomas: characteristics, influence factors and precautions]. | the patient-derived tumor xenografts (pdx) model is an animal model established by directly engrafting fresh tumor tissue of patients into immunodeficiency mice after surgery or biopsy, which plays an important role in the study of tumor biology. however, the transformation of pdx into lymphoma limits the application of this model. the characters of this transformation include that epithelial tumors origin, predorminance of b-cell lymphomas, lost of architectural feature of primary tumor, absenc ... | 2016 | 27452762 |
| approach for identifying human leukocyte antigen (hla)-dr bound peptides from scarce clinical samples. | immune-mediated diseases strongly associating with human leukocyte antigen (hla) alleles are likely linked to specific antigens. these antigens are presented to t cells in the form of peptides bound to hla molecules on antigen presenting cells, e.g. dendritic cells, macrophages or b cells. the identification of hla-dr-bound peptides presents a valuable tool to investigate the human immunopeptidome. the lung is likely a key player in the activation of potentially auto-aggressive t cells prior to ... | 2016 | 27452731 |
| uncommon structural motifs dominate the antigen binding site in human autoantibodies reactive with basement membrane collagen. | autoantibodies mediate organ destruction in multiple autoimmune diseases, yet their origins in patients remain poorly understood. to probe the genetic origins and structure of disease-associated autoantibodies, we engrafted immunodeficient mice with human cd34+ hematopoietic stem cells and immunized with the non-collagenous-1 (nc1) domain of the alpha3 chain of type iv collagen. this antigen is expressed in lungs and kidneys and is targeted by autoantibodies in anti-glomerular basement membrane ... | 2016 | 27450516 |
| correlation between overall survival and differential plasma and tissue tumor marker expression in nasopharyngeal carcinoma patients with different sites of organ metastasis. | differential overall survival of nasopharyngeal carcinoma (npc) with different organ site metastases has been documented. here, we attempted to determine the underlying mechanisms by assessing plasma and tumor tissue markers in relation to patient survival. pretreatment plasma epstein-barr virus (ebv) dna concentrations, cytokines and tissue macrophages, proliferation and apoptosis markers were determined in 178 patients with metastatic npc. the median overall survival (os) was 19 months. patien ... | 2016 | 27448966 |
| chronic fatigue syndrome: searching for the cause and treatment. | chronic fatigue syndrome exploded into the nation's consciousness in 1985 with a pseudoepidemic in a nevada resort community. initially and erroneously linked to the epstein-barr virus, the cause of this puzzling blend of largely subjective features continues to elude researchers. | 1989 | 27447327 |
| ebv-negative monomorphic b-cell post-transplant lymphoproliferative disorders are pathologically distinct from ebv-positive cases and frequently contain tp53 mutations. | monomorphic post-transplant lymphoproliferative disorder commonly resembles diffuse large b-cell lymphoma or burkitt lymphoma, and most are epstein-barr virus (ebv) positive. we retrospectively identified 32 cases of monomorphic post-transplant lymphoproliferative disorder from two institutions and evaluated ebv in situ hybridization; tp53 mutation status; p53, cd30, myc, and bcl2 expression by immunohistochemistry; proliferation index by ki67; and germinal center vs non-germinal center immunoph ... | 2016 | 27443517 |
| short chain fatty acids (scfa) reprogram gene expression in human malignant epithelial and lymphoid cells. | the effect of short chain fatty acids (scfas) on gene expression in human, malignant cell lines was investigated, with a focus on signaling pathways. the commensal microbial flora produce high levels of scfas with established physiologic effects in humans. the most abundant scfa metabolite in the human microflora is n-butyric acid. it is well known to activate endogenous latent epstein-barr virus (ebv), that was used as a reference read out system and extended to ebv+ epithelial cancer cell line ... | 2016 | 27441625 |
| epstein-barr virus oncoprotein lmp1 mediates epigenetic changes in host gene expression through parp1. | the latent infection of epstein-barr virus (ebv) is associated with 1% of human cancer incidence. poly(adp-ribosyl)ation (parylation) is a posttranslational modification catalyzed by poly(adp-ribose) polymerases (parps) that mediate ebv replication during latency. in this study, we detail the mechanisms that drive cellular parylation during latent ebv infection and the effects of parylation on host gene expression and cellular function. ebv-infected b cells had higher par levels than ebv-negativ ... | 2016 | 27440880 |
| modulation of pd-l1 and cd8 activity in idiopathic and infectious chronic inflammatory conditions. | programmed death-ligand 1 (pd-l1) can reduce the immune response by inhibiting cd8 t-cell proliferation and cytotoxic activity. we studied a series of human viral (molloscum, human papillomavirus, herpes simplex, cytomegalovirus, epstein-barr virus, smallpox) and bacterial infections (helicobacter pylori) for the in situ expression of pd-l1, mononuclear cell infiltration, and cd8 activity and compared this to noninfectious idiopathic inflammatory conditions to better define which immune response ... | 2017 | 27438510 |
| epstein-barr virus barf1-induced nfκb/mir-146a/smad4 alterations in stomach cancer cells. | epstein-barr virus (ebv)-encoded bamhi-a rightward frame 1 (barf1) is a putative viral oncogene in ebv-infected stomach cancer. the aim of the present study was to investigate barf1-induced cellular protein and microrna alterations. in this study, barf1-expressing stomach cancer cells showed a high rate of proliferation, high levels of nfκb, and mir-146a upregulation, which was reversed by nfκb knockdown. during barf1-induced nfκb upregulation, hcsf1 receptor level was unchanged. knockdown of ba ... | 2016 | 27438138 |
| subcutaneous panniculitis-like t-cell lymphoma: a rare tumour. | subcutaneous panniculitis like t cell lymphoma (sptcl) is an uncommon variant and poorly differentiated type of cutaneous t cell lymphoma. here we describe the case of a 19-year-old female who presented with swelling of left half of the face with no regional lymphadenopathy and hepatosplenomegaly which was initially misdiagnosed as a benign cutaneous condition by various practitioners. histopathological examination revealed diffuse infiltration of subcutaneous plane by small to medium sized atyp ... | 2016 | 27437288 |
| chronic epstein barr virus infection leading to classical hodgkin lymphoma. | chronic epstein barr virus (ebv) infection in an immunocompetent host has been described however it is not a common entity. it has been linked to many lymphoproliferative disorders and achieves such via many molecular mechanisms, some of which are poorly understood. in addition to infectious mononucleosis, the ebv is linked to various other hematological pathologies and autoimmune disorders. | 2016 | 27437106 |
| tumor heterogeneity measured on f-18 fluorodeoxyglucose positron emission tomography/computed tomography combined with plasma epstein-barr virus load predicts prognosis in patients with primary nasopharyngeal carcinoma. | plasma epstein-barr virus (ebv) dna concentrations predict prognosis in patients with nasopharyngeal carcinoma (npc). recent evidence also indicates that intratumor heterogeneity on f-18 fluorodeoxyglucose positron emission tomography ((18) f-fdg pet) scans is predictive of treatment outcomes in different solid malignancies. here, we sought to investigate the prognostic value of heterogeneity parameters in patients with primary npc. | 2017 | 27435352 |
| cytomegalovirus and epstein-barr virus reactivation in the intensive care unit. | the purpose of this work was to evaluate the reactivation of cytomegalovirus (cmv) and epstein-barr virus (ebv) in immunocompetent patients in the intensive care unit (icu) and to identify risk factors associated with reactivation. | 2016 | 27435067 |
| pancreatitis and cholecystitis in primary acute symptomatic epstein-barr virus infection - systematic review of the literature. | acute pancreatitis and acalculous cholecystitis have been occasionally reported in primary acute symptomatic epstein-barr virus infection. we completed a review of the literature and retained 48 scientific reports published between 1966 and 2016 for the final analysis. acute pancreatitis was recognized in 14 and acalculous cholecystitis in 37 patients with primary acute symptomatic epstein-barr virus infection. in all patients, the features of acute pancreatitis or acalculous cholecystitis concu ... | 2016 | 27434148 |
| epstein-barr virus-associated acute cholecystitis in a teenager. | a 14-year-old girl was admitted to hospital with fever, headache, sore throat and abdominal pain. her blood lymphocyte count and inflammatory markers were raised. acute epstein-barr virus (ebv) infection was suspected and confirmed serologically and by measuring the viral load. on day 7, she developed jaundice with abnormal liver function tests. an abdominal ultrasound scan revealed thickening of the gallbladder and bile duct walls without calculi suggesting acute acalculous cholecystitis. the p ... | 2014 | 27433206 |
| infectious complications with the use of biologic response modifiers in infants and children. | biologic response modifiers (brms) are substances that interact with and modify the host immune system. brms that dampen the immune system are used to treat conditions such as juvenile idiopathic arthritis, psoriatic arthritis, or inflammatory bowel disease and often in combination with other immunosuppressive agents, such as methotrexate and corticosteroids. cytokines that are targeted include tumor necrosis factor α; interleukins (ils) 6, 12, and 23; and the receptors for il-1α (il-1a) and il- ... | 2016 | 27432853 |
| microrna-183 suppresses cancer stem-like cell properties in ebv-associated nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is an epstein-barr virus (ebv)-associated epithelial malignancy that exhibits distinct geographical and ethnic prevalence. although the contemporary therapeutic approach of radio-/chemotherapy provides excellent results for patients with early-stage disease, it is far from satisfactory for those with disease remission and distant metastasis. promising therapeutic strategies for advanced and relapsed npc are still lacking. we recently identified and characterized a ... | 2016 | 27431799 |
| epstein-barr virus-negative diffuse large b cell lymphoma with aberrant expression of cd3 and other t cell-associated antigens: report of three cases with a review of the literature. | expression of cd3 on a mature b cell neoplasm, such as diffuse large b cell lymphoma (dlbcl), is extremely rare. when it is present, it will cause diagnostic confusion since the classification of lymphoid neoplasms is largely based on immunophenotyping to determine the cell lineage. we report three cases of dlbcl with cd3 and other t cell-associated antigens. a literature search identifies 30 additional cases of dlbcl expressing cd3, with the majority (78.6 %) displaying cytoplasmic expression, ... | 2016 | 27431583 |
| decitabine inhibits tumor cell proliferation and up-regulates e-cadherin expression in epstein-barr virus-associated gastric cancer. | the present study investigated the effect of a dna demethylating agent, decitabine, against epstein-barr virus-associated gastric cancer (ebvagc). decitabine inhibited cell growth and induced g2/m arrest and apoptosis in ebvagc cell lines. the expression of e-cadherin was up-regulated and cell motility was significantly inhibited in the cells treated with decitabine. the promoter regions of p73 and runx3 were demethylated, and their expression was up-regulated by decitabine. they enhanced the tr ... | 2017 | 27430892 |
| epstein-barr virus strains and variations: geographic or disease-specific variants? | the epstein-barr virus (ebv) is associated with the development of several diseases, including infectious mononucleosis (im), burkitt's lymphoma (bl), nasopharyngeal carcinoma, and other neoplasias. the publication of ebv genome 1984 led to several studies regarding the identification of different viral strains. currently, ebv is divided into ebv type 1 (b95-8 strain) and ebv type 2 (ag876 strain), also known as type a and type b, which have been distinguished based upon genetic differences in t ... | 2017 | 27430663 |
| cytotoxic effects of nf‑κb inhibitors in combination with anti‑herpes agents on epstein‑barr virus‑positive gastric carcinoma in vitro. | epstein-barr virus (ebv) infection in tumor cells is usually restricted to the latent form, indicating that the induction of viral lytic infection may present a novel approach for the treatment of ebv‑associated tumors. by contrast, ebv lytic replication is inhibited by high‑levels of nuclear factor (nf)‑κb, which suggests that nf‑κb inhibitors may activate lytic replication from the latent form. in the current study, the addition of nf‑κb inhibitors (bay11‑7082, z‑llf‑cho and aspirin) was obser ... | 2016 | 27430429 |
| axonal polyneuropathy as an unusual manifestation of acute epstein-barr virus infection in an adult. | 2016 | 27430089 | |
| viral colonization in exhaled breath condensate of lung cancer patients: possible role of ebv and cmv. | today, an increasing interest is being addressed to the viral etiology of lung tumors. as a consequence, research efforts are currently being directed to the identification of the new viruses involved in lung carcinogenesis toward which the screening programs could be directed. | 2016 | 27421948 |
| gene sharing between epstein-barr virus and human immune response genes. | epstein-barr virus (also termed hhv-4, ebv), a component of the human virome or metagenome, is associated as a co-factor in many common human autoimmune diseases through epidemiologic evidence. numerous ebv genes are functional as well as structural homologues of important immune response genes. for example, ebv-encoded bcrf1 is a functional homologue of il-10, a critical cytokine regulator of immune tolerance. bzlf-1, an ebv-encoded transcription factor, contains regions with functional homolog ... | 2016 | 27421718 |
| secondary malignant neoplasms following haematopoietic stem cell transplantation in childhood. | improving survival rates in children with malignancy have been achieved at the cost of a high frequency of late adverse effects of treatment, especially in intensively treated patients such as those undergoing haematopoietic stem cell transplantation (hsct), many of whom suffer the high burden of chronic toxicity. secondary malignant neoplasms (smns) are one of the most devastating late effects, cause much morbidity and are the most frequent cause of late (yet still premature) treatment-related ... | 2015 | 27417356 |
| the haematologist and the infective complications of hiv infection. | patients with aids often have haematological abnormalities consequent on opportunistic infections, superimposed on abnormalities caused by hiv itself. it is important for the haematologist to recognize characteristic features such as a marked increase in plasma cells and the presence of pleomorphic lymphoid aggregates in order to avoid misdiagnosis of a plasma cell dyscrasia or a lymphoma. examination of the peripheral blood and bone marrow can also be useful in permitting the diagnosis of speci ... | 1998 | 27416480 |
| how genetic testing can lead to targeted management of xiap deficiency-related inflammatory bowel disease. | x-linked lymphoproliferative disease type 2 (xlp-2, omim 300635) is a primary immunodeficiency caused by the loss of x chromosome-linked inhibitor of apoptosis (xiap), the x-linked inhibitor of apoptosis gene at xq25. xlp-2 individuals are susceptible to several specific and potentially fatal infections, such as epstein-barr virus (ebv). children with xiap-related xlp-2 may present with either familial hemophagocytic lymphohistiocytosis, often triggered in response to ebv infection, or with a tr ... | 2017 | 27416006 |
| epstein-barr virus gastric ulcer associated with ruxolitinib. | 2016 | 27411541 | |
| can burkitt's lymphoma and hodgkin's lymphoma occur in siblings simultaneously? | familial clustering of hodgkin lymphoma (hl) and increased risk of developing disease among the siblings has been reported earlier. usually familial lymphoma in sibling pairs occurs in the pairs of either non-hodgkin lymphoma or hl. in the familial hl, same type of human leukocyte antigens (hla) is responsible in the affected family members. there are also some studies stating "killer cell immunoglobulin like receptor (kir)" genotypes can be important in the etiology of familial hl. here we repo ... | 2017 | 27411427 |
| association of epstein-barr virus (ebv) but not human papillomavirus (hpv) with gingivitis and/or periodontitis in transplanted individuals. | the aim of this study was to investigate the association of ebv and hpv with gingivitis and/or periodontitis according to the immunologic status. to this end, 74 oral biopsies from transplanted and non-transplanted individuals with the abovementioned oral manifestations were submitted to a screening by pcr for both viruses. according to the results, ebv was strongly associated with gingivitis and/or periodontitis in transplanted individuals (p = 0.011) but not hpv (p = 0.766). ebv-hpv co-detecti ... | 2016 | 27410918 |
| global transcript structure resolution of high gene density genomes through multi-platform data integration. | annotation of herpesvirus genomes has traditionally been undertaken through the detection of open reading frames and other genomic motifs, supplemented with sequencing of individual cdnas. second generation sequencing and high-density microarray studies have revealed vastly greater herpesvirus transcriptome complexity than is captured by existing annotation. the pervasive nature of overlapping transcription throughout herpesvirus genomes, however, poses substantial problems in resolving transcri ... | 2016 | 27407110 |
| the value of circulating cyfra21-1 expression in patients with nasopharyngeal carcinoma: a study of 529 subjects. | early diagnosis of nasopharyngeal carcinoma (npc) needs more reliable biomarkers. the aim of this study was to investigate serum cytokeratin 19 fragment 21.1 (cyfra21-1) as an npc biomarker based on data from a large sample. | 2016 | 27405513 |
| recipient-derived ebv-positive monomorphic plasmacytoma type posttransplant lymphoproliferative disorder after allogeneic stem cell transplant for severe aplastic anemia: a case report. | monomorphic plasmacytoma-type posttransplant lymphoproliferative disorder (ptld) has not been reported after pediatric hematopoietic stem cell transplantation. we present a child with hepatitis-associated severe aplastic anemia who underwent an unrelated allogeneic hematopoietic stem cell transplantation and subsequently developed graft failure and an epstein-barr virus-positive monomorphic plasmacytoma-type ptld of recipient origin. despite broad-spectrum antimicrobials, weaning immunosuppressi ... | 2016 | 27403771 |
| co-infection with helicobacter pylori and epstein-barr virus in benign upper digestive diseases: an endoscopic and serologic pilot study. | some gastric cancers are epstein-barr virus associated. | 2016 | 27403305 |
| follicular dendritic cell sarcoma: clinicopathologic study of 15 cases with emphasis on novel expression of mdm2, somatostatin receptor 2a, and pd-l1. | follicular dendritic cell sarcoma (fdcs) is a rare low-grade neoplasm with the phenotype of fdc cells. this rare sarcoma has been well known for being mistaken for a variety of neoplasms (mainly meningioma), particularly at extranodal sites. diagnosis of fdcs mainly relies on characteristic histologic appearance supplemented by immunohistochemistry and electron microscopy. in this study, we reviewed 15 fdcss retrieved from our consultation files and stained them for newly reported or novel marke ... | 2016 | 27402219 |
| a comprehensive next generation sequencing-based virome assessment in brain tissue suggests no major virus - tumor association. | next generation sequencing (ngs) can globally interrogate the genetic composition of biological samples in an unbiased yet sensitive manner. the objective of this study was to utilize the capabilities of ngs to investigate the reported association between glioblastoma multiforme (gbm) and human cytomegalovirus (hcmv). a large-scale comprehensive virome assessment was performed on publicly available sequencing datasets from the cancer genome atlas (tcga), including rna-seq datasets from primary g ... | 2016 | 27402152 |
| biological and molecular characterization of a rare case of cutaneous richter syndrome. | richter syndrome (rs) is the transformation of chronic lymphocytic leukemia in a high-grade lymphoma usually presenting nodal and bone marrow involvement. richter syndrome can be localized at extranodal sites including the gastrointestinal tract, lungs, and skin. cutaneous rs is an extremely rare disease apparently showing a less aggressive course than common presentations. while nodal rs has been extensively investigated in literature, pathogenesis and prognosis of cutaneous rs are still partia ... | 2016 | 27400669 |
| interleukin (il)-39 [il-23p19/epstein-barr virus-induced 3 (ebi3)] induces differentiation/expansion of neutrophils in lupus-prone mice. | interleukin (il)-12 family cytokines play critical roles in autoimmune diseases. our previous study has shown that il-23p19 and epstein-barr virus-induced 3 (ebi3) form a new il-12 family heterodimer, il-23p19/ebi3, termed il-39, and knock-down of p19 or ebi3 reduced diseases by transferred gl7(+) b cells in lupus-prone mice. in the present study, we explore further the possible effect of il-39 on murine lupus. we found that il-39 in vitro and in vivo induces differentiation and/or expansion of ... | 2016 | 27400195 |
| a nomogram for predicting survival of nasopharyngeal carcinoma patients with metachronous metastasis. | patients with metachronous metastatic nasopharyngeal carcinoma (npc) differ significantly in survival outcomes. the aim of this study is to build a clinically practical nomogram incorporating known tumor prognostic factors to predict survival for metastatic npc patients in epidemic areas.a total of 860 patients with metachronous metastatic nasopharyngeal carcinoma were analyzed retrospectively. variables assessed were age, gender, body mass index, karnofsky performance status (kps), union for in ... | 2016 | 27399084 |
| increased epstein-barr virus in breast milk occurs with subclinical mastitis and hiv shedding. | epstein-barr virus (ebv) in breast milk and subclinical mastitis (scm) are both associated with human immunodeficiency virus (hiv) shedding and possibly with postnatal hiv transmission. the objective of this nested case-control study was to investigate the interplay between scm and ebv replication in breast milk of hiv-infected mothers.the relationships between ebv deoxyribonucleic acid (dna) shedding, hiv-1 ribonucleic acid (rna) level, and scm were explored in breast milk samples of zambian mo ... | 2016 | 27399077 |
| the effect of self-reported health on latent herpesvirus reactivation and inflammation in an ethnically diverse sample. | self-rated health (srh) is a reliable predictor of health outcomes including morbidity and mortality. immune dysregulation is one hypothesized mechanism underlying the association between srh and health outcomes. indeed, poorer srh is associated with greater inflammation. the association between srh and reactivation of latent herpesviruses is unknown, representing an important gap in the literature given that reactivation of latent herpesviruses leads to enhanced inflammation. the present study ... | 2016 | 27398881 |