Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| correction for mavigner et al., "simian immunodeficiency virus persistence in cellular and anatomic reservoirs in antiretroviral therapy-suppressed infant rhesus macaques". | 2019 | 30655382 | |
| simian immunodeficiency virus transiently increases brain temperature in rhesus monkeys: detection with magnetic resonance spectroscopy thermometry. | to evaluate brain temperature effects of early simian immunodeficiency virus (siv) infection in rhesus macaques using proton magnetic resonance spectroscopy (mrs) thermometry (mrst) and to determine whether temperature correlates with brain choline or myo-inositol levels. | 2019 | 30652349 |
| functional characterization for polymorphic organic anion transporting polypeptides (oatp/slco1b1, 1b3, 2b1) of monkeys recombinantly expressed with various oatp probes. | the hepatic uptake of clinical drugs mediated by human hepatic organic anion transporting polypeptides (oatp/slco) has been reported extensively. in this study, hepatic uptake by recombinantly expressed monkey oatp1b1, oatp1b3 and oatp2b1 was investigated using three human oatp1b1 and oatp1b3 substrates (pitavastatin, pravastatin and rosuvastatin) and one oatp1b3 substrate (telmisartan), as the governmental drug interaction guidelines recommend, and seven reported clinical drugs. the uptake of k ... | 2019 | 30652318 |
| clade c hiv-1 envelope vaccination regimens differ in their ability to elicit antibodies with moderate neutralization breadth against genetically diverse tier 2 hiv-1 envelope variants. | the goals of preclinical hiv vaccine studies in nonhuman primates are to develop and test different approaches for their ability to generate protective immunity. here, we compared the impact of 7 different vaccine modalities, all expressing the hiv-1 1086.c clade c envelope (env), on (i) the magnitude and durability of antigen-specific serum antibody responses and (ii) autologous and heterologous neutralizing antibody capacity. these vaccination regimens included immunization with different comb ... | 2019 | 30651354 |
| clinical characterization of host response to simian hemorrhagic fever virus infection in permissive and refractory hosts: a model for determining mechanisms of vhf pathogenesis. | simian hemorrhagic fever virus (shfv) causes a fulminant and typically lethal viral hemorrhagic fever (vhf) in macaques (cercopithecinae: macaca spp.) but causes subclinical infections in patas monkeys (cercopithecinae: erythrocebus patas). this difference in disease course offers a unique opportunity to compare host responses to infection by a vhf-causing virus in biologically similar susceptible and refractory animals. patas and rhesus monkeys were inoculated side-by-side with shfv. unlike the ... | 2019 | 30650570 |
| altered expression of p63 isoforms and expansion of p63- and club cell secretory protein-positive epithelial cells in the lung as novel features of aging. | aging is a key contributor for subclinical progression of late-onset lung diseases. basal, club, and type ii alveolar epithelial cells (aecs) are lung epithelial progenitors whose capacities of differentiation are extensively studied. the timely transition of these cells in response to environmental changes helps maintain the intricate organization of lung structure. however, it remains unclear how aging affects their behavior. this paper demonstrates that the protein expression profiles of a ty ... | 2019 | 30649915 |
| chronic ethanol drinking increases during the luteal menstrual cycle phase in rhesus monkeys: implication of progesterone and related neurosteroids. | sporadic reports of alcohol consumption being linked to menstrual cycle phase highlight the need to consider hormonally characterized menstrual cycle phase in understanding the sex-specific effects of risk for alcohol drinking in women. | 2019 | 30645681 |
| doppler and oscillometric mean blood pressure best represent direct blood pressure measurements in anesthetized rhesus macaques (macaca mulatta). | indirect blood pressure measurements are often used to guide clinical decisions, but few studies have verified their agreement with direct arterial blood pressure in nonhuman primates. here, the accuracy and precision of doppler (dop) and oscillometric (os) [systolic (ossys), mean (osmean), and diastolic (osdias)] blood pressure readings were assessed in rhesus macaques. | 2019 | 30644561 |
| mr extracellular volume mapping and non-contrast t1ρ mapping allow early detection of myocardial fibrosis in diabetic monkeys. | to detect diffuse myocardial fibrosis in different severity levels of left ventricular diastolic dysfunction (dd) in spontaneous type 2 diabetes mellitus (t2dm) rhesus monkeys. | 2019 | 30643944 |
| vaccine protection against sivmac239 acquisition. | the biological characteristics of hiv pose serious difficulties for the success of a preventive vaccine. molecularly cloned sivmac239 is difficult for antibodies to neutralize, and a variety of vaccine approaches have had great difficulty achieving protective immunity against it in rhesus monkey models. here we report significant protection against i.v. acquisition of sivmac239 using a long-lasting approach to vaccination. the vaccine regimen includes a replication-competent herpesvirus engineer ... | 2019 | 30642966 |
| immunological responses to the relapsing fever spirochete borrelia turicatae in infected rhesus macaques: implications for pathogenesis and diagnosis. | the global public health impact of relapsing fever (rf) spirochetosis is significant, since the pathogens exist on five of seven continents. the hallmark sign of infection is episodic fever and the greatest threat is to the unborn. with the goal of better understanding the specificity of b-cell responses and the role of immune responses in pathogenicity, we infected rhesus macaques with borrelia turicatae (a new world rf spirochete species) by tick bite and monitored the immune responses generat ... | 2019 | 30642902 |
| needle-free delivery of dna: targeting of hemagglutinin to mhc class ii molecules protects rhesus macaques against h1n1 influenza. | conventional influenza vaccines are hampered by slow and limited production capabilities, whereas dna vaccines can be rapidly produced for global coverage in the event of an emerging pandemic. however, a drawback of dna vaccines is their generally low immunogenicity in non-human primates and humans. we have previously demonstrated that targeting of influenza hemagglutinin to human hla class ii molecules can increase antibody responses in larger animals such as ferrets and pigs. here, we extend t ... | 2019 | 30638800 |
| very long-chain c24:1 ceramide is increased in serum extracellular vesicles with aging and can induce senescence in bone-derived mesenchymal stem cells. | extracellular vesicles (evs), including exosomes and microvesicles, function in cell-to-cell communication through delivery of proteins, lipids and micrornas to target cells via endocytosis and membrane fusion. these vesicles are enriched in ceramide, a sphingolipid associated with the promotion of cell senescence and apoptosis. we investigated the ceramide profile of serum exosomes from young (24⁻40 yrs.) and older (75⁻90 yrs.) women and young (6⁻10 yrs.) and older (25⁻30 yrs.) rhesus macaques ... | 2019 | 30634626 |
| development and in vivo evaluation of a κ-opioid receptor agonist as a pet radiotracer with superior imaging characteristics. | studies have shown κ-opioid receptor (kor) abnormalities in addictive disorders, other central nervous system diseases, and alzheimer's disease. we have developed the first set of agonist 11c-gr103545 and antagonist 11c-ly2795050 radiotracers for pet imaging of kor in humans. nonetheless, 11c-gr103545 displays protracted uptake kinetics and is not an optimal radiotracer. here, we report the development and evaluation of 11c-methyl-(r)-4-(2-(3,4-dichlorophenyl)acetyl)-3-((diethylamino)methyl)pipe ... | 2019 | 30630942 |
| regional anesthesia for dentistry and orofacial surgery in rhesus macaques (macaca mulatta). | regional anesthesia is a commonly used adjunct to orofacial dental and surgical procedures in companion animals and humans. however, appropriate techniques for anesthetizing branches of the mandibular and maxillary nerves have not been described for rhesus monkeys. skulls of 3 adult rhesus monkeys were examined to identify relevant foramina, establish appropriate landmarks for injection, and estimate injection angles and depth. cadaver heads of 7 adult rhesus monkeys (4 male, 3 female) were then ... | 2019 | 30630557 |
| a computational model of dual competition between the basal ganglia and the cortex. | we propose a model that includes interactions between the cortex, the basal ganglia (bg), and the thalamus based on a dual competition. we hypothesize that the striatum, the subthalamic nucleus (stn), the internal globus pallidus (gpi), the thalamus, and the cortex are involved in closed feedback loops through the hyperdirect and direct pathways. these loops support a competition process that results in the ability of bg to make a cognitive decision followed by a motor one. considering lateral c ... | 2020 | 30627653 |
| rescue of rhesus macaques from the lethality of aerosolized ricin toxin. | ricin toxin (rt) ranks at the top of the list of bioweapons of concern to civilian and military personnel alike, due to its high potential for morbidity and mortality after inhalation. in nonhuman primates, aerosolized ricin triggers severe acute respiratory distress characterized by perivascular and alveolar edema, neutrophilic infiltration, and severe necrotizing bronchiolitis and alveolitis. there are currently no approved countermeasures for ricin intoxication. here, we report the therapeuti ... | 2019 | 30626745 |
| rhesus macaque rhadinovirus encodes a viral interferon regulatory factor to disrupt promyelocytic leukemia nuclear bodies and antagonize type i interferon signaling. | interferon (ifn) production and the subsequent induction of ifn-stimulated genes (isgs) are highly effective innate strategies utilized by cells to protect against invading pathogens, including viruses. critical components involved in this innate process are promyelocytic leukemia nuclear bodies (pml-nbs), which are subnuclear structures required for the development of a robust ifn response. as such, pml-nbs serve as an important hurdle for viruses to overcome to successfully establish an infect ... | 2019 | 30626678 |
| histopathological features of the development of intestine and mesenteric lymph node injury in a nonhuman primate model of partial-body irradiation with minimal bone marrow sparing. | male rhesus macaques were subjected to partial-body irradiation at 10, 11, or 12 gy with 5% bone marrow protection. animals were euthanized when dictated by prospectively determined clinical parameters or at approximately 180 d following irradiation. histological sections of jejunum, colon, and mesenteric lymph node were stained with hematoxylin and eosin as well as a battery of histochemical and immunohistochemical stains. the immediate postirradiation histopathological alterations in the jejun ... | 2019 | 30624355 |
| the gastrointestinal subsyndrome of the acute radiation syndrome in rhesus macaques: a systematic review of the lethal dose-response relationship with and without medical management. | well-characterized animal models that mimic the human response to potentially lethal doses of radiation are required to assess the efficacy of medical countermeasures under the criteria of the us food and drug administration's animal rule. development of a model for the gastrointestinal acute radiation syndrome requires knowledge of the radiation dose-response relationship and time course of mortality and morbidity across the acute and prolonged gastrointestinal radiation syndrome. the nonhuman ... | 2019 | 30624353 |
| radiation nephropathy in a nonhuman primate model of partial-body irradiation with minimal bone marrow sparing-part 2: histopathology, mediators, and mechanisms. | male rhesus macaques were subjected to partial-body irradiation at 10, 11, or 12 gy with 5% bone marrow protection. animals were euthanized when dictated by prospectively determined clinical parameters or at approximately 180 d following irradiation. histological sections of kidney were stained with hematoxylin and eosin as well as a battery of histochemical and immunohistochemical stains. histopathological alterations were centered on glomerular changes and fibrosis of glomeruli and the interst ... | 2019 | 30624348 |
| plasma lipidomic signatures of spontaneous obese rhesus monkeys. | obesity plays crucial roles in the pathogenesis of metabolic diseases such as hyperlipidemia, nonalcoholic fatty liver disease (nafld), and type 2 diabetes (t2d). the underlying mechanisms linking obesity to metabolic diseases are still less understandable. | 2019 | 30621707 |
| contrast sensitivity reveals an oculomotor strategy for temporally encoding space. | the contrast sensitivity function (csf), how sensitivity varies with the frequency of the stimulus, is a fundamental assessment of visual performance. the csf is generally assumed to be determined by low-level sensory processes. however, the spatial sensitivities of neurons in the early visual pathways, as measured in experiments with immobilized eyes, diverge from psychophysical csf measurements in primates. under natural viewing conditions, as in typical psychophysical measurements, humans con ... | 2019 | 30620333 |
| rotavirus is associated with decompensated diarrhea among young rhesus macaques (macaca mulatta). | diarrhea with secondary decompensation is the main cause of morbidity and mortality in captive young rhesus macaque (macaca mulatta) colonies. approximately 25% of diarrhea cases with secondary decompensation are considered to be idiopathic chronic diarrhea. the purpose of this study was to investigate the suspected but not systematically examined association between rotavirus infection and diarrhea with secondary decompensation among young rhesus macaques at the california national primate rese ... | 2019 | 30620103 |
| varicella virus-host interactions during latency and reactivation: lessons from simian varicella virus. | varicella zoster virus (vzv) is a neurotropic alphaherpesvirus and the causative agent of varicella (chickenpox) in humans. following primary infection, vzv establishes latency in the sensory ganglia and can reactivate to cause herpes zoster, more commonly known as shingles, which causes significant morbidity, and on rare occasions mortality, in the elderly. because vzv infection is highly restricted to humans, the development of a reliable animal model has been challenging, and our understandin ... | 2018 | 30619226 |
| anti-hypercholesterolemic effects and a good safety profile of scm-198 in animals: from apoe knockout mice to rhesus monkeys. | although several lipid-lowering agents have been introduced for the treatment of atherosclerosis (as), currently marketed medications have not solved the problem completely. this study aims to investigate the effects of leonurine (scm-198) on dyslipidemia in mammals with apoe knockout (apoe-/-) mice, new zealand white rabbits and senile rhesus monkeys fed with high fat diet were dosed daily with leonurine or atorvastatin. the serum total cholesterol (tc), triglyceride (tg), low density lipoprote ... | 2018 | 30618759 |
| a method to investigate astrocyte and microglial morphological changes in the aging brain of the rhesus macaque. | with a rapidly aging population, studies of neuroinflammation and degeneration associated with eugeric aging are becoming critical. using the unique archive at the tulane national primate research center as a resource, we have developed tools to quantify morphological changes in astrocytes and microglia across the life span of monkeys. this method can be used for morphometric studies of multiple parameters simultaneously in an unbiased manner. | 2019 | 30617987 |
| modulation of gpr39, a g-protein coupled receptor associated with alcohol use in non-human primates, curbs ethanol intake in mice. | alcohol use disorder (aud) is a chronic condition with devastating health and socioeconomic effects. still, pharmacotherapies to treat aud are scarce. in a prior study aimed at identifying novel aud therapeutic targets, we investigated the dna methylome of the nucleus accumbens core (nacc) of rhesus macaques after chronic alcohol use. the g-protein coupled receptor 39 (gpr39) gene was hypermethylated and its expression downregulated in heavy alcohol drinking macaques. gpr39 encodes a zn2+-bindin ... | 2019 | 30610192 |
| frequency shifts and depth dependence of premotor beta band activity during perceptual decision-making. | neural activity in the premotor and motor cortices shows prominent structure in the beta frequency range (13-30 hz). currently, the behavioral relevance of this beta band activity (bba) is debated. the underlying source of motor bba and how it changes as a function of cortical depth are also not completely understood. here, we addressed these unresolved questions by investigating bba recorded using laminar electrodes in the dorsal premotor cortex of 2 male rhesus macaques performing a visual rea ... | 2019 | 30606756 |
| sevoflurane exposure has minimal effect on cognitive function and does not alter microglial activation in adult monkeys. | postoperative cognitive dysfunction (pocd) is a complication that has been observed in a subset of adult and elderly individuals after general anesthesia and surgery. although the pathogenesis of pocd is largely unknown, a growing body of preclinical research suggests that pocd may be caused by general anesthesia. a significant amount of research has examined the effects of general anesthesia on neurocognitive function in rodents, yet no studies have assessed the adverse effects of general anest ... | 2019 | 30605762 |
| the concentration of copper, zinc, manganese and selenium in the serum and liver of goats with caprine arthritis-encephalitis. | concentrations of four trace elements, copper (cu), zinc (zn), manganese (mn) and seleni- um (se), have thus far proven to be affected by lentiviral infections in people and rhesus monkeys. as small ruminant lentivirus (srlv) infection is responsible for one of the most important goat diseases, caprine arthritis-encephalitis (cae), we evaluated serum and liver concentrations of cu, zn, mn, se in goats severely affected by symptomatic cae and compared them with litera- ture reference intervals. s ... | 2018 | 30605285 |
| induction of rhesus keratinocytes into functional ameloblasts by mouse embryonic dental mesenchyme. | fast progresses in stem cell-based tooth tissue engineering have been achieved in recent years in several animal models including the mouse, rat, dog, and pig. moreover, various postnatal mesenchymal stem cells of dental origin have been isolated and shown capable of differentiating into odontoblasts and generating dentin. meanwhile, human keratinocyte stem/progenitor cells, gingival epithelial cells, and even ipsc-derived epithelium have been demonstrated to be able to differentiate into functi ... | 2018 | 30603545 |
| use of nonhuman primates for the development of bioengineered female reproductive organs. | nonhuman primates (nhps) have been widely used in reproductive biology, neuroscience, and drug development since a number of primate species are phylogenetically close to humans. in this review, we summarize the use of nhps for nonclinical application in the reproductive system disorders including the loss or failure of an organ or tissue. causes of infertility include congenital aplasia and acquired disorders of the reproductive organs. in addition, anti-cancer treatments can deplete ovarian fo ... | 2016 | 30603414 |
| functionally defined white matter of the macaque monkey brain reveals a dorso-ventral attention network. | classical studies of attention have identified areas of parietal and frontal cortex as sources of attentional control. recently, a ventral region in the macaque temporal cortex, the posterior infero-temporal dorsal area pitd, has been suggested as a third attentional control area. this raises the question of whether and how spatially distant areas coordinate a joint focus of attention. here we tested the hypothesis that parieto-frontal attention areas and pitd are directly interconnected. by com ... | 2019 | 30601116 |
| aging affects correlation within the v1 neuronal population in rhesus monkeys. | visual function declines with age. this deterioration results not only from changes in the optical system but also from the functional degradation of the central visual cortex. although numerous studies have explored the mechanisms of age-related influences on vision, they have failed to acknowledge the significance of neuronal correlation in dysfunction of the visual cortex. previous research has focused on the functional degradation of individual neurons, with age-induced changes in correlatio ... | 2019 | 30599290 |
| modeling the measles paradox reveals the importance of cellular immunity in regulating viral clearance. | measles virus (mv) is a highly contagious member of the morbillivirus genus that remains a major cause of childhood mortality worldwide. although infection induces a strong mv-specific immune response that clears viral load and confers lifelong immunity, transient immunosuppression can also occur, leaving the host vulnerable to colonization from secondary pathogens. this apparent contradiction of viral clearance in the face of immunosuppression underlies what is often referred to as the 'measles ... | 2018 | 30592772 |
| ratio of the bronchial lumen to pulmonary artery diameter in rhesus macaques (macaca mulatta) without clinical pulmonary disease. | in human medicine, ct is widely used to detect changes in bronchial luminal diameter. the diameter of the artery that runs adjacent to the bronchus does not change dramatically along the airway path, such that this artery can be used as a reference to detect changes in the bronchial luminal diameter. the bronchoarterial ratio is increasingly used in veterinary medicine for the detection of lower airway diseases in animals. the purpose of this study was to establish the bronchoarterial ratio in r ... | 2019 | 30591089 |
| gonadotrophin-mediated mirna expression in testis at onset of puberty in rhesus monkey: predictions on regulation of thyroid hormone activity and dlk1-dio3 locus. | molecular mechanisms responsible for the initiation of primate spermatogenesis remain poorly characterized. previously, 48 h stimulation of the testes of three juvenile rhesus monkeys with pulsatile lh and fsh resulted in down-regulation of a cohort of genes recognized to favor spermatogonia stem cell renewal. this change in genetic landscape occurred in concert with amplification of sertoli cell proliferation and the commitment of undifferentiated spermatogonia to differentiate. in this report, ... | 2019 | 30590698 |
| a likelihood approach to testing hypotheses on the co-evolution of epigenome and genome. | central questions to epigenome evolution include whether interspecies changes of histone modifications are independent of evolutionary changes of dna, and if there is dependence whether they depend on any specific types of dna sequence changes. here, we present a likelihood approach for testing hypotheses on the co-evolution of genome and histone modifications. the gist of this approach is to convert evolutionary biology hypotheses into probabilistic forms, by explicitly expressing the joint pro ... | 2018 | 30586383 |
| testosterone augments fsh signaling by upregulating the expression and activity of fsh-receptor in pubertal primate sertoli cells. | the synergistic actions of testosterone (t) and fsh via testicular sertoli cells (sc) regulate male fertility. we have previously reported that the actions of these hormones (t and fsh) in infant monkey testes are restricted only to the expansion of sc and spermatogonial cells. the robust differentiation of male germ cells (gc) occurs after pubertal maturation of testis. the present study was aimed to investigate the molecular basis of the synergy between t and fsh action in pubertal primate (ma ... | 2019 | 30579957 |
| prevention of sivmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy. | the precise time when the viral reservoir is seeded during acute hiv-1 infection remains unclear. we previously demonstrated that the viral reservoir was seeded by day 3 following sivmac251 infection in rhesus monkeys. here we report the impact of initiating art on day 0 (6 h), 1, 2, or 3 following intrarectal sivmac251 infection in 20 rhesus monkeys (n = 5/group). after 6 months of daily suppressive art, antiretroviral drugs were discontinued, and viral rebound was monitored. 0% (0 of 5), 20% ( ... | 2018 | 30575753 |
| the scalar property during isochronous tapping is disrupted by a d2-like agonist in the nonhuman primate. | dopamine, and specifically the d2 system, has been implicated in timing tasks where the absolute duration of individual time intervals is encoded discretely, yet the role of d2 during beat perception and entrainment remains largely unknown. in this type of timing, a beat is perceived as the pulse that marks equally spaced points in time and, once extracted, produces the tendency in humans to entrain or synchronize their movements to it. hence, beat-based timing is crucial for musical execution. ... | 2019 | 30575431 |
| dynamic changes in insulin and glucagon during disease progression in rhesus monkeys with obesity-related type 2 diabetes mellitus. | to investigate the progression of obesity-related type 2 diabetes mellitus (t2dm) in rhesus monkeys, especially dynamic changes in insulin and glucagon. | 2019 | 30575251 |
| optic nerve degeneration and reduced contrast sensitivity due to folic acid deficiency: a behavioral and electrophysiological study in rhesus monkeys. | the purpose of the research was to elucidate the role of folic acid (b9) deficiency in the development of nutritional optic neuritis and to characterize the neurophysiological consequences of optic nerve degeneration in the cortical visual system. | 2018 | 30574659 |
| neural coding of intended and executed grasp force in macaque areas aip, f5, and m1. | considerable progress has been made over the last decades in characterizing the neural coding of hand shape, but grasp force has been largely ignored. we trained two macaque monkeys (macaca mulatta) on a delayed grasping task where grip type and grip force were instructed. neural population activity was recorded from areas relevant for grasp planning and execution: the anterior intraparietal area (aip), f5 of the ventral premotor cortex, and the hand area of the primary motor cortex (m1). grasp ... | 2018 | 30573765 |
| the caudal part of putamen represents the historical object value information. | the basal ganglia, especially the circuits originating from the putamen, are essential for controlling normal body movements. notably, the putamen receives inputs not only from motor cortical areas but also from multiple sensory cortices. however, how these sensory signals are processed in the putamen remains unclear. we recorded the activity of tentative medium spiny neurons in the caudal part of the putamen when the monkey viewed many fractal objects. we found many neurons that responded to th ... | 2019 | 30573645 |
| 'artiphysiology' reveals v4-like shape tuning in a deep network trained for image classification. | deep networks provide a potentially rich interconnection between neuroscientific and artificial approaches to understanding visual intelligence, but the relationship between artificial and neural representations of complex visual form has not been elucidated at the level of single-unit selectivity. taking the approach of an electrophysiologist to characterizing single cnn units, we found many units exhibit translation-invariant boundary curvature selectivity approaching that of exemplar neurons ... | 2018 | 30570484 |
| neonatal rhesus monkeys as an animal model for rotavirus infection. | to establish a rotavirus (rv)-induced diarrhea model using rv sa11 in neonatal rhesus monkeys for the study of the pathogenic and immune mechanisms of rv infection and evaluation of candidate vaccines. | 2018 | 30568388 |
| concurrent influence of top-down and bottom-up inputs on correlated activity of macaque extrastriate neurons. | correlations between neurons can profoundly impact the information encoding capacity of a neural population. we studied how maintenance of visuospatial information affects correlated activity in visual areas by recording the activity of neurons in visual area mt of rhesus macaques during a spatial working memory task. correlations between mt neurons depended upon the spatial overlap between neurons' receptive fields. these correlations were influenced by the content of working memory, but the ef ... | 2018 | 30568166 |
| comparative analysis of gammaherpesvirus circular rna repertoires: conserved and unique viral circular rnas. | recent studies have identified circular rnas (circrnas) expressed from the epstein-barr virus (ebv) and kaposi's sarcoma herpesvirus (kshv) human dna tumor viruses. to gain initial insights into the potential relevance of ebv circrnas in virus biology and disease, we assessed the circrnaome of the interspecies homologue rhesus macaque lymphocryptovirus (rlcv) in a naturally occurring lymphoma from a simian immunodeficiency virus (siv)-infected rhesus macaque. this analysis revealed rlcv ortholog ... | 2019 | 30567979 |
| conservation implications of primate trade in china over 18 years based on web news reports of confiscations. | primate species have been increasingly threatened by legal and illegal trade in china, mainly for biomedical research or as pets and traditional medicine, yet most reports on trade from china regard international trade. to assess a proxy for amount of national primate trades, we quantified the number of reports of native primate species featuring in unique web news reports from 2000 to 2017, including accuracy of their identification, location where they were confiscated or rescued, and their co ... | 2018 | 30564524 |
| extensive alternative splicing of kir transcripts. | the killer-cell ig-like receptors (kir) form a multigene entity involved in modulating immune responses through interactions with mhc class i molecules. the complexity of the kir cluster is reflected by, for instance, abundant levels of allelic polymorphism, gene copy number variation, and stochastic expression profiles. the current transcriptome study involving human and macaque families demonstrates that kir family members are also subjected to differential levels of alternative splicing, and ... | 2018 | 30564240 |
| the foxk1-ccdc43 axis promotes the invasion and metastasis of colorectal cancer cells. | the ccdc43 gene is conserved in human, rhesus monkey, mouse and zebrafish. bioinformatics studies have demonstrated the abnormal expression of ccdc43 gene in colorectal cancer (crc). however, the role and molecular mechanism of ccdc43 in crc remain unknown. | 2018 | 30562730 |
| human cytomegalovirus-vectored vaccines against hiv. | cmv-vectored vaccines expressing siv antigens have mediated unprecedented levels of virus control following siv challenge in rhesus macaques. remarkably, protection was dependent on nonclassically restricted cd8 t cells. here, we review the latest research in cmv-vectored vaccines in both humans and nonhuman primates as well as recent advances in the understanding nonclassically restricted t cells, particularly mhc-e-restricted cd8 t cells. | 2019 | 30562176 |
| neuronal variability and tuning are balanced to optimize naturalistic self-motion coding in primate vestibular pathways. | it is commonly assumed that the brain's neural coding strategies are adapted to the statistics of natural stimuli. specifically, to maximize information transmission, a sensory neuron's tuning function should effectively oppose the decaying stimulus spectral power, such that the neural response is temporally decorrelated (i.e. 'whitened'). however, theory predicts that the structure of neuronal variability also plays an essential role in determining how coding is optimized. here, we provide expe ... | 2018 | 30561328 |
| novel spheroid reservoir bioartificial liver improves survival of nonhuman primates in a toxin-induced model of acute liver failure. | this study aims to evaluate the effectiveness and safety of the spheroid reservoir bioartificial liver (srbal) with porcine hepatocyte organoids in a preclinical nonhuman primate model of acute liver failure (alf). methods: thirty healthy rhesus monkeys were infused with α-amanitin and lipopolysaccharide and randomized into five groups (alf alone control group; sham no-cell srbal treatment group; groups a, b and c with srbal treatment started at 12 h, 24 h and 36 h after induction of alf, respec ... | 2018 | 30555564 |
| synaptic adaptations in the central amygdala and hypothalamic paraventricular nucleus associated with protracted ethanol abstinence in male rhesus monkeys. | alcohol use disorder is a significant global burden. stress has been identified as an etiological factor in the initiation and continuation of ethanol consumption. understanding adaptations within stress circuitry is an important step toward novel treatment strategies. the effects of protracted abstinence following long-term ethanol self-administration on the central nucleus of the amygdala (cea) and the hypothalamic paraventricular nucleus (pvn) were evaluated in male rhesus monkeys. using whol ... | 2019 | 30555160 |
| a randomized controlled laboratory study on the long-term effects of methylphenidate on cardiovascular function and structure in rhesus monkeys. | whether long-term methylphenidate (mph) results in any changes in cardiovascular function or structure can only be properly addressed through a randomized trial using an animal model which permits elevated dosing over an extended period of time. | 2019 | 30555154 |
| absence of spontaneous regeneration of endogenous pancreatic β-cells after chemical-induced diabetes and no effect of gaba on α-to-β cell transdifferentiation in rhesus monkeys. | β-cell deficiency is common feature of type 1 and late-stage of type 2 diabetes mellitus. thus, β-cell replacement therapy has been the focus of regenerative medicine past several decades. particularly, evidences suggest that β-cell regeneration via transdifferentiation from sources including α-cells is promising. however, data using higher mammals besides rodents are scarce. here, we examined whether endogenous pancreatic β-cells could regenerate spontaneously or under normoglycemia following p ... | 2019 | 30553443 |
| role of mu-opioid agonist efficacy on antinociceptive interactions between mu agonists and the nociceptin opioid peptide agonist ro 64-6198 in rhesus monkeys. | mu-opioid receptor agonists are clinically effective analgesics, but also produce undesirable effects that limit their clinical utility. the nociceptin opioid peptide (nop) receptor system also modulates nociception, and nop agonists might be useful adjuncts to enhance the analgesic effects or attenuate the undesirable effects of mu-opioid agonists. the present study determined behavioral interactions between the nop agonist (-)-ro 64-6198 and mu-opioid ligands that vary in mu-opioid receptor ef ... | 2019 | 30552903 |
| periventricular microglial cells interact with dividing precursor cells in the nonhuman primate and rodent prenatal cerebral cortex. | cortical proliferative zones have been studied for over 100 years, yet recent data have revealed that microglial cells constitute a sizeable proportion of ventricular zone cells during late stages of cortical neurogenesis. microglia begin colonizing the forebrain after neural tube closure and during later stages of neurogenesis populate regions of the developing cortex that include the proliferative zones. we previously showed that microglia regulate the production of cortical cells by phagocyto ... | 2019 | 30552670 |
| vaccine-induced protection from homologous tier 2 shiv challenge in nonhuman primates depends on serum-neutralizing antibody titers. | passive administration of hiv neutralizing antibodies (nabs) can protect macaques from hard-to-neutralize (tier 2) chimeric simian-human immunodeficiency virus (shiv) challenge. however, conditions for nab-mediated protection after vaccination have not been established. here, we selected groups of 6 rhesus macaques with either high or low serum nab titers from a total of 78 animals immunized with recombinant native-like (sosip) env trimers. repeat intrarectal challenge with homologous tier 2 shi ... | 2019 | 30552025 |
| preference for attractive faces is species-specific. | studies on facial attractiveness in human adults, infants, and newborns have consistently reported a visual preference for faces rated as attractive compared with faces rated as unattractive. biological accounts of facial attractiveness have typically presented such preferences as arising from adaptations for mate choice or as by-products of general sensory bias. in this cross-species study, we examined whether explicit ratings of attractiveness made by human judges would predict implicit visual ... | 2019 | 30550303 |
| detecting neurodevelopmental effects of early-gestation ethanol exposure: a nonhuman primate model of ethanol drinking during pregnancy. | gestational ethanol (etoh) exposure is associated with multiple developmental abnormalities, collectively termed fetal alcohol spectrum disorder (fasd). while the majority of women abstain from etoh following knowledge of pregnancy, one contributing factor to the high fasd prevalence is that pregnancy is not detected until 4 to 6 weeks. thus, etoh consumption continues during the initial stages of fetal development. | 2019 | 30549282 |
| quantification of infectious sendai virus using plaque assay. | sendai virus (sev) is an enveloped, single-stranded rna virus of the family paramyxoviridae. sev is a useful tool to study its infectious pathomechanism in immunology and the pathomechanism of a murine model of iga nephropathy. virus quantification is essential not only to determine the original viral titers for an appropriate application, but also to measure the viral titers in samples from the harvests from experiments. there are mainly a couple of units/titers for sendai viral quantification: ... | 2018 | 30547053 |
| aav8 gene therapy for crigler-najjar syndrome in macaques elicited transgene t cell responses that are resident to the liver. | systemic delivery of adeno-associated viral (aav) vectors has been evaluated for the treatment of several liver diseases, including homozygous familial hypercholesterolemia, ornithine transcarbamylase deficiency, and hemophilia. here, we evaluated this approach for the treatment of crigler-najjar syndrome. we administered wild-type rhesus macaques with 1.0 × 1013 or 2.5 × 1013 genome copies/kg of an aav serotype 8 vector expressing a codon-optimized version of human uridine diphosphate glucurono ... | 2018 | 30547050 |
| barcoding of macaque hematopoietic stem and progenitor cells: a robust platform to assess vector genotoxicity. | gene therapies using integrating retrovirus vectors to modify hematopoietic stem and progenitor cells have shown great promise for the treatment of immune system and hematologic diseases. however, activation of proto-oncogenes via insertional mutagenesis has resulted in the development of leukemia. we have utilized cellular bar coding to investigate the impact of different vector designs on the clonal behavior of hematopoietic stem and progenitor cells (hspcs) during in vivo expansion, as a quan ... | 2018 | 30547048 |
| spatiotemporal transcriptomic divergence across human and macaque brain development. | human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. we generated tissue-level and single-cell transcriptomic data from up to 16 brain regions covering prenatal and postnatal rhesus macaque development. integrative analysis with complementary human data revealed that global intraspecies (ontogenetic) and interspecies (phylogenetic) regional transcriptomic differences exhibit concerted cup-shaped patterns, with a ... | 2018 | 30545855 |
| early maternal recognition of offspring vocalizations in rhesus macaques (macaca mulatta). | this study investigated the development of maternal recognition of infant calls in rhesus macaques (macaca mulatta). fifteen mothers and their offspring, of age ranging from several hours to 28 days, served as subjects of an experiment in which the offspring's distress vocalizations were recorded and then played back to their mothers simultaneously with those of an age-matched control infant. the proportion of time looking at, but not the proportion of orientations to the speaker playing the off ... | 2000 | 30545206 |
| impaired reconciliation in rhesus macaques with a history of early weaning and disturbed socialization. | an attempt had been made to create five social groups from rhesus macaques with a history of early separation from their mothers, early weaning and hand feeding and, in most cases, previous housing in single cages. we investigated the exchange of affiliative behaviours after an aggressive encounter and selective attraction to the former opponent, a phenomenon previously well described in rhesus monkeys and called reconciliation. evidence for reconciliation was only found in one of the five group ... | 2000 | 30545193 |
| the development of behavioural sex differences in infant rhesus macaques (macaca mulatta). | studies of infant rhesus macaques have generally reported sex differences in the frequency of expression of some behaviour patterns, such as rough-and-tumble play and socio-sexual mounting. in contrast, sex differences in other behaviour patterns, such as proximity to the mother, have been less consistantly reported. using data on the behavioural development of infant rhesus macaques living in captive social groups, we have attempted to provide further evidence for, or against, sex differences i ... | 2000 | 30545192 |
| allelic variation of the serotonin transporter gene polymorphic region in apes. | to assess the change of serotonin transporter (5-htt) gene-linked polymorphic region that has occurred during the process of hominization, we examined the allelic variation of 5-htt gene-linked polymorphic region (5-httlpr) in anthropoid apes such as chimpanzees, gorillas, orang-utans, and gibbons, and determined the dna sequences of the alleles in each species. all chimpanzees examined shared only the 17.5 repeat allele, while polymorphism was observed in the other apes and the 16 and 20 repeat ... | 2000 | 30545178 |
| subclinical infection of macaques and baboons with a baboon simarterivirus. | simarteriviruses (arteriviridae: simarterivirinae) are commonly found at high titers in the blood of african monkeys but do not cause overt disease in these hosts. in contrast, simarteriviruses cause severe disease in asian macaques upon accidental or experimental transmission. here, we sought to better understand the host-dependent drivers of simarterivirus pathogenesis by infecting olive baboons (n = 4) and rhesus monkeys (n = 4) with the simarterivirus southwest baboon virus 1 (swbv-1). surpr ... | 2018 | 30544677 |
| immunotoxin-induced ablation of the intrinsically photosensitive retinal ganglion cells in rhesus monkeys. | purpose: intrinsically photosensitive retinal ganglion cells (iprgcs) contain the photopigment melanopsin, and are primarily involved in non-image forming functions, such as the pupillary light reflex and circadian rhythm entrainment. the goal of this study was to develop and validate a targeted iprgc immunotoxin to ultimately examine the role of iprgcs in macaque monkeys. methods: an immunotoxin for the macaque melanopsin gene (opn4), consisting of a saporin-conjugated antibody directed at the ... | 2018 | 30542318 |
| diversity of ulbp5 in old-world monkeys (cercopithecidae) and divergence of the ulbp gene family in primates. | non-human primates such as rhesus macaque and cynomolgus macaque are important animals for medical research. these species are classified as old-world monkeys (cercopithecidae), in which the immune-related genome structure is characterized by gene duplications. in the present study, we investigated polymorphisms in two genes for ulbp5 encoding ligands for nkg2d. we found 18 and 11 ulbp5.1 alleles and 11 and 13 ulbp5.2 alleles in rhesus macaques and cynomolgus macaques, respectively. in addition, ... | 2018 | 30541969 |
| the frequency of vaccine-induced t-cell responses does not predict the rate of acquisition after repeated intrarectal sivmac239 challenges in mamu-b*08+ rhesus macaques. | approximately 50% of rhesus macaques (rms) expressing the major histocompatibility complex class i (mhc-i) allele mamu-b*08 spontaneously control chronic-phase viremia after infection with the pathogenic simian immunodeficiency virus mac239 (sivmac239) clone. cd8+ t-cell responses in these animals are focused on immunodominant mamu-b*08-restricted siv epitopes in vif and nef, and prophylactic vaccination with these epitopes increases the incidence of elite control in sivmac239-infected mamu-b*08 ... | 2019 | 30541854 |
| coadministration of ch31 broadly neutralizing antibody does not affect development of vaccine-induced anti-hiv-1 envelope antibody responses in infant rhesus macaques. | prevention of mother-to-child transmission (mtct) is an indispensable component in combatting the global aids epidemic. a combination of passive broadly neutralizing antibody (bnab) infusion and active vaccination promises to provide protection of infants against mtct from birth through the breastfeeding period and could prime the immune system for lifelong immunity. in this study, we investigate the impact of a single infusion of cd4 binding site (cd4bs) bnab administered at birth on de novo an ... | 2019 | 30541851 |
| novel modified vaccinia virus ankara vector expressing anti-apoptotic gene b13r delays apoptosis and enhances humoral responses. | modified vaccinia virus ankara (mva), an attenuated poxvirus, has been developed as a potential vaccine vector for use against cancer and multiple infectious diseases, including human immunodeficiency virus (hiv). mva is highly immunogenic and elicits strong cellular and humoral responses in preclinical models and humans. however, there is potential to further enhance the immunogenicity of mva, as mva-infected cells undergo rapid apoptosis, leading to faster clearance of recombinant antigens and ... | 2019 | 30541829 |
| longitudinal evaluation of pulmonary arterial hypertension in a rhesus macaque (macaca mulatta) model of hiv infection. | pulmonary arterial hypertension (pah) is a life-threatening disease with higher incidence in hiv-infected compared with noninfected patients. siv-infected nhp develop clinical manifestations of hiv infection, including pah. to understand the pathogenesis of pah and determine the relationship between hemodynamic changes and clinical characteristics associated with siv infection, we performed right heart catheterization and echocardiographic imaging of 21 rhesus macaques before and after siv infec ... | 2018 | 30541636 |
| transfer function of the rhesus macaque oculomotor system for small-amplitude slow motion trajectories. | two main types of small eye movements occur during gaze fixation: microsaccades and slow ocular drifts. while microsaccade generation has been relatively well studied, ocular drift control mechanisms are unknown. here we explored the degree to which monkey smooth eye movements, on the velocity scale of slow ocular drifts, can be generated systematically. two male rhesus macaque monkeys tracked a spot moving sinusoidally, but slowly, along the horizontal or vertical direction. maximum target disp ... | 2019 | 30540500 |
| author correction: transcription start site profiling of 15 anatomical regions of the macaca mulatta central nervous system. | the authors regret that luba m. pardo was omitted in error from the author list of the original version of this data descriptor. this omission has now been corrected in the html and pdf versions. the authors also regret that anemieke rozemuller was omitted in error from the acknowledgements of the original version of this data descriptor. this omission has now been corrected in the html and pdf versions. | 2018 | 30538238 |
| social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques. | low social status is an important predictor of disease susceptibility and mortality risk in humans and other social mammals. these effects are thought to stem in part from dysregulation of the glucocorticoid (gc)-mediated stress response. however, the molecular mechanisms that connect low social status and gc dysregulation to downstream health outcomes remain elusive. here, we used an in vitro gc challenge to investigate the consequences of experimentally manipulated social status (i.e., dominan ... | 2019 | 30538209 |
| dominance rank-associated gene expression is widespread, sex-specific, and a precursor to high social status in wild male baboons. | in humans and other hierarchical species, social status is tightly linked to variation in health and fitness-related traits. experimental manipulations of social status in female rhesus macaques suggest that this relationship is partially explained by status effects on immune gene regulation. however, social hierarchies are established and maintained in different ways across species: while some are based on kin-directed nepotism, others emerge from direct physical competition. we investigated ho ... | 2018 | 30538194 |
| quality, bioactivity study, and preclinical acute toxicity, safety pharmacology evaluation of pegylated recombinant human endostatin (m2 es). | endostar, a potent endogenous antiangiogenic factor, is wildly used in clinics. however, it was easily degraded by enzymes and rapidly cleared by the kidneys. to overcome these shortcomings, pegylated recombinant human endostatin was developed. in this study, the purity of m2 es was evaluated by silver stain and reversed-phase high-performance liquid chromatography. ultraviolet spectrum was used to examine the structural of m2 es and endostar. the bioactivity and antitumor efficacy of m2 es were ... | 2019 | 30536793 |
| complete genome sequences of six novel macaca mulatta papillomavirus types isolated from genital sites of rhesus monkeys in hong kong sar, china. | the complete genomes of six macaca mulatta papillomavirus types isolated from genital sites of rhesus monkeys were characterized, and less than 72% identity with the complete l1 genes of known papillomaviruses was found. macaca mulatta papillomavirus type 2 (mmpv2), mmpv3, and mmpv6 cluster into the genus alphapapillomavirus, and mmpv4, mmpv5, and mmpv7 cluster into the genus gammapapillomavirus. | 2018 | 30533857 |
| myeloid cells in intact human cervical explants capture hiv and can transmit it to cd4 t cells. | the importance of myeloid cells in hiv transmission in the female genital tract is uncertain. because it is difficult to study the early events in hiv transmission in humans, most of our knowledge is based on animal models of siv infection in rhesus macaques and more recently hiv infection in humanized mice. however, these models may not accurately recapitulate transmission in the human genital tract. cd14+ myeloid cells are the most abundant hematopoietic cells in the human cervical mucosa, com ... | 2018 | 30532754 |
| a novel large animal model of recurrent migraine established by repeated administration of inflammatory soup into the dura mater of the rhesus monkey. | several animal models of migraine have been established, and those based on trigeminovascular system activation are widely accepted. however, most of these models have been established on lower animals, such as rodents, and involve only a single administration of a noxious stimulus. in this study, an inflammatory soup (10 μl), consisting of prostaglandin e2 (0.2 mm), serotonin (2 mm), bradykinin (2 mm) and histamine (2 mm), was injected into the dura mater of conscious rhesus monkeys through an ... | 2019 | 30531083 |
| changes in endogenous dopamine induced by methylphenidate predict functional connectivity in nonhuman primates. | dopamine (da) levels in the striatum are increased by many therapeutic drugs, such as methylphenidate (mph), which also alters behavioral and cognitive functions thought to be controlled by the pfc dose-dependently. we linked da changes and functional connectivity (fc) using simultaneous [18f]fallypride pet and resting-state fmri in awake male rhesus monkeys after oral administration of various doses of mph. we found a negative correlation between [18f]fallypride nondisplaceable binding potentia ... | 2019 | 30530859 |
| neural intrinsic timescales in the macaque dorsal premotor cortex predict the strength of spatial response coding. | our brain continuously receives information over multiple timescales that are differently processed across areas. in this study, we investigated the intrinsic timescale of neurons in the dorsal premotor cortex (pmd) of two rhesus macaques while performing a non-match-to-goal task. the task rule was to reject the previously chosen target and select the alternative one. we defined the intrinsic timescale as the decay constant of the autocorrelation structure computed during a baseline period of th ... | 2018 | 30529952 |
| spike detection and spike sorting with a hidden markov model improves offline decoding of motor cortical recordings. | detection and sorting (classification) of action potentials from extracellular recordings are two important pre-processing steps for brain-computer interfaces (bcis) and some neuroscientific studies. traditional approaches perform these two steps serially, but using shapes of action potential waveforms during detection, i.e. combining the two steps, may lead to better performance, especially during high noise. we propose a hidden markov model (hmm) based method for combined detecting and sorting ... | 2019 | 30523823 |
| a comparative study of the pharmacokinetics of clozapine n-oxide and clozapine n-oxide hydrochloride salt in rhesus macaques. | translating chemogenetic techniques from nonhuman primates to potential clinical applications has been complicated in part due to in vivo conversion of the chemogenetic actuator, clozapine n-oxide (cno), to its pharmacologically active parent compound, clozapine, a ligand with known side effects, including five boxed warnings from the food and drug administration. additionally, the limited solubility of cno requires high concentrations of potentially toxic detergents such as dimethylsulfoxide (d ... | 2019 | 30523062 |
| comparison of vaccination with rhesus cmv (rhcmv) soluble gb with a rhcmv replication-defective virus deleted for mhc class i immune evasion genes in a rhcmv challenge model. | a human cytomegalovirus (hcmv) vaccine to prevent infection and/or reduce disease associated with congenital infection or visceral disease in transplant recipients is a high priority, but has remained elusive. we created a disabled infectious single cycle rhesus cmv (rhcmv) deleted for glycoprotein l (gl) and the mhc class i immune evasion genes rh178 and rh182-189, and restored its epithelial cell tropism by inserting the rh128-131a genes. the resulting virus, rhcmvrδgl/178/182-189, was used to ... | 2019 | 30522906 |
| 13c-lutein is differentially distributed in tissues of an adult female rhesus macaque following a single oral administration: a pilot study. | despite the growing awareness regarding lutein's putative roles in eyes and brain, its pharmacokinetics and tissue distribution in primates have been poorly understood. we hypothesized that 13c-lutein will be differentially distributed into tissues of an adult rhesus macaque (macaca mulatta) 3 days following a single oral dose. after a year of prefeeding a diet supplemented with unlabeled lutein (1 μmol/kg/d), a 19-year-old female was dosed with 1.92 mg of highly enriched 13c-lutein. tissues of ... | 2019 | 30522845 |
| cmv primes functional alternative signaling in adaptive δg nk cells but is subverted by lentivirus infection in rhesus macaques. | despite burgeoning evidence demonstrating the adaptive properties of natural killer (nk) cells, mechanistic data explaining these phenomena are lacking. following antibody sensitization, nk cells lacking the fc receptor (fcr) signaling chain (δg) acquire adaptive features, including robust proliferation, multifunctionality, rapid killing, and mobilization to sites of virus exposure. using the rhesus macaque model, we demonstrate the systemic distribution of δg nk cells expressing memory features ... | 2018 | 30517864 |
| vectored delivery of anti-siv envelope targeting mab via aav8 protects rhesus macaques from repeated limiting dose intrarectal swarm sivsme660 challenge. | gene based delivery of immunoglobulins promises to safely and durably provide protective immunity to individuals at risk of acquiring infectious diseases such as hiv. we used a rhesus macaque animal model to optimize delivery of naturally-arising, autologous anti-siv neutralizing antibodies expressed by adeno-associated virus 8 (aav8) vectors. vectored transgene expression was confirmed by quantitation of target antibody abundance in serum and mucosal surfaces. we tested the expression achieved ... | 2018 | 30517201 |
| altering alpha-frequency brain oscillations with rapid analog feedback-driven neurostimulation. | oscillations of the brain's local field potential (lfp) may coordinate neural ensembles and brain networks. it has been difficult to causally test this model or to translate its implications into treatments, because there are few reliable ways to alter lfp oscillations. we developed a closed-loop analog circuit to enhance brain oscillations by feeding them back into cortex through phase-locked transcranial electrical stimulation. we tested the system in a rhesus macaque with chronically implante ... | 2018 | 30517149 |
| identification of expressed mirnas in human rheumatoid arthritis using computational approach - discovery of a new mir-7167 from human. | rheumatoid arthritis (ra) is a chronic inflammatory and autoimmune disease leading to bones and joints destruction. it is one of the major causes of lifetime disability and mortality among humans in the developing and developed countries. it was evident that epigenetic dysregulation is related to the pathogenesis of ra. micrornas (mirnas) are small non-coding rnas that are epigenetic regulators for diverse biological processes and also provided novel molecular insights in the formation of arthri ... | 2019 | 30514198 |
| recognition memory in marmoset and macaque monkeys: a comparison of active vision. | the core functional organization of the primate brain is remarkably conserved across the order, but behavioral differences evident between species likely reflect derived modifications in the underlying neural processes. here, we performed the first study to directly compare visual recognition memory in two primate species-rhesus macaques and marmoset monkeys-on the same visual preferential looking task as a first step toward identifying similarities and differences in this cognitive process acro ... | 2019 | 30513042 |
| genetic and environmental factors in the intergenerational transmission of maternal care in rhesus macaques: preliminary findings. | early life experiences reorganize the brain and behavior of the developing infant, often with lifelong consequences. there is perhaps no more potent developmental influence than the quality of parental care: it is an experience common to all mammals, and its effects have been observed across species. the effects of parental care can be particularly difficult to abolish, as levels of care are often perpetuated across generations. however, genetic relatedness between parents can obscure the true m ... | 2018 | 30512216 |
| in vitro analysis of synthetic peptides in blocking the entry of dengue virus. | dengue fever is the most prevalent arthropod-borne viral disease, and no specific therapeutic or promising antiviral drug is available for its treatment. peptide inhibitors are less toxic than synthetic compounds and have found proven effective against viral infections. here, three peptides that mimic part of the e protein of the dengue virus (denv) were synthesized and evaluated for their inhibitory activity against four serotypes of denv in african green monkey kidney (vero) and rhesus macaque ... | 2019 | 30508603 |