Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| a unique t-cell line derived from an htlv-1-negative adult t-cell leukemia patient. | a unique t-cell line, designated atl-5t, was established from lymphoma cells in pericardial effusion of an adult t-cell leukemia (atl) patient not carrying htlv-1 provirus. the cell line is okt4 and/or leu3a+ and okt8 and/or leu2a+, but interleukin 2 receptor (il2r)- and htlv-1 provirus genome negative, and has cytogenetically abnormal karyotypes. the cell line contains rearranged t-cell receptor beta-chain gene, which was identical in rearrangement pattern to the t-cell receptor beta-chain gene ... | 1987 | 2890613 |
| the kidd (jk) blood group locus assigned to chromosome 18 by close linkage to a dna-rflp. | the close linkage between the psti-restriction fragment length polymorphism (rflp) disclosed by the l2.7 genomic dna probe and the kidd blood group locus is described. the maximum lod score is +8.53 at recombination fraction theta = 0.03. the upper probability limit of the recombination fraction is theta 1 = 0.11. the l2.7 probe, previously assigned provisionally to chromosome 17, is by the present study assigned to chromosome 18. this also assigns the kidd blood group locus (jk) to chromosome 1 ... | 1987 | 2890568 |
| cytopathic effect of verotoxin on endothelial cells. | 1987 | 2889952 | |
| measurement of six enzymes with the kodak dtsc module, a physician's office analyzer. | we evaluated the performance of the kodak dtsc module for determination of alanine aminotransferase (alt; ec 2.6.1.2), aspartate aminotransferase (2.5.1.2), alkaline phosphatase (3.1.3.1), creatine kinase (2.7.3.2), gamma-glutamyltransferase (2.3.2.2), and lactate dehydrogenase (1.1.1.27). the dtsc is a "special chemistry" accessory for the dt60 analyzer; the same multilayer film technology as that of the ektachem 700 is used. the overall precision, assessed over a three-month period with two se ... | 2010 | 2889544 |
| airway responsiveness in infancy. | 2009 | 2889415 | |
| [surgical treatment of tumor-induced destruction of the spine]. | surgery for treatment of destructions of the spine varies depending on localization and tumour status. if the body of the vertebra is affected, the ventral approach allows radical tumour resection as far as possible. the following stabilization is effected by filling the defect and carrying out osteosynthetical fusion. of 38 patients, three had benign tumours, whereas ten patients had primary malignant and 25 had metastatic tumours. the results show that surgical treatment is justified also in p ... | 2010 | 2889329 |
| vitamin b12 deficiency, demyelination, and multiple sclerosis. | 2010 | 2889118 | |
| antibiotic dependence in a strain of neisseria pharyngis. | a strain of neisseria pharyngis was isolated in pure culture from a specimen of sputum. growth was markedly enhanced by sub-lethal concentrations of rifampicin, spectinomycin, erythromycin and clindamycin. the effect was temporary with tetracycline. the possible mechanisms of this phenomenon are discussed. | 1987 | 2888818 |
| a hypervariable repeated sequence on human chromosome 1p36. | when used to probe southern blots of taqi-digested dnas from unrelated individuals, p1-79, a 900 bp subclone of a random human cosmid, revealed at least 50 fragments, many of which were polymorphic. each of 27 unrelated individuals tested with p1-79 displayed a distinct band pattern. similar variation was seen with several other enzymes, including haeiii, mspi, psti and pvuii, whereas other enzymes yielded primarily large fragments of greater than 40 kb. in situ hybridization of p1-79 showed tha ... | 1987 | 2888721 |
| a hypervariable repeated sequence on human chromosome 1p36. | when used to probe southern blots of taqi-digested dnas from unrelated individuals, p1-79, a 900 bp subclone of a random human cosmid, revealed at least 50 fragments, many of which were polymorphic. each of 27 unrelated individuals tested with p1-79 displayed a distinct band pattern. similar variation was seen with several other enzymes, including haeiii, mspi, psti and pvuii, whereas other enzymes yielded primarily large fragments of greater than 40 kb. in situ hybridization of p1-79 showed tha ... | 1987 | 2888721 |
| immunoglobulin vh region genes of the mouse are organized in overlapping clusters. | restriction fragment length polymorphism has been compared between the igh loci of c57bl/6 and molf/ei (mus musculus molossinus) mice utilizing probes which detect the c gamma 2b gene and genes from nine vh-gene families. distinct restriction site patterns were found for the ch genes and for vh families pc7183, q52 and x24. vh families v31 and j558 showed identical patterns. mixed patterns of identical and distinct bands were detected in vh families s107, j606, v3660 and vgam3.8. this indicates ... | 1987 | 2888660 |
| influence of chemical factors on maximum temperature and residual monomer in cold curing acrylic resin. | 2010 | 2888404 | |
| [study on the incidence and anatomo-clinical forms of digestive alcoholic pathology in hospitalized patients]. | 2009 | 2888175 | |
| mechanism of action of somatostatin in the hippocampal slice. | 1987 | 2888131 | |
| the wellcome foundation lecture, 1986. the molecular regulators of normal and leukaemic blood cells. | the development of a cell-culture system for the cloning and clonal differentiation of different types of blood cell has made it possible to identify: (i), the proteins that regulate growth and differentiation of different cell lineages in normal and leukaemic blood cells; (ii), the molecular basis of normal and abnormal control of cell development in blood-forming tissue; and (iii), how to suppress malignancy in leukaemic cells. by using myeloid blood cells as a model system, it has been shown ... | 2009 | 2888120 |
| activation of a common effector system by different brain neurotransmitter receptors in xenopus oocytes. | xenopus oocytes possess 'native' muscarinic receptors, which give rise to oscillatory chloride currents; similar responses are elicited by activation of foreign receptors to serotonin, glutamate and noradrenaline, expressed in oocytes after injection of messenger rna from rat brain. when low concentrations of two agonists are applied together, the combined response is greater than would be expected from the sum of the responses to each agonist applied alone. potentiation of acetylcholine by sero ... | 1987 | 2888117 |
| cells, vaccines, and world health. | 2010 | 2887947 | |
| british nutrition foundation. | 2010 | 2887815 | |
| combination treatment: colloidal bismuth subcitrate with h2-antagonists. | a formal single-blind multicentre study has been set up to investigate the probable benefit of combined therapy of the cytoprotective agent de-nol (colloidal bismuth subcitrate, cbs) and an acid-suppressing drug (cimetidine) in the treatment of duodenal ulcer. the protocol compares the therapeutic benefit of cbs alone and cimetidine alone with cbs + cimetidine, the treatment period being 28 or 56 days. patients whose ulcers heal within the therapeutic phase will be followed up until relapse or 1 ... | 2010 | 2887475 |
| serum levels of bilirubin and biliverdin in the sea lamprey, petromyzon marinus l., before and after their biliary atresia. | 1. the sera of ammocoetes, juvenile adults, and upstream migrants of the sea lamprey, petromyzon marinus l., were analyzed for the presence of the bile pigments, biliverdin and bilirubin. 2. bile pigment was not detected in the sera of ammocoetes. 3. after biliary atresia (degeneration of bile ducts at metamorphosis), bilirubin and biliverdin were detected in the sera of both juvenile adults and upstream migrants. 4. these data suggest that lampreys have some bile stasis following biliary atresi ... | 2010 | 2887360 |
| short-term intensive therapy for childhood non-hodgkin lymphoma. | 2009 | 2886850 | |
| antibiotics for exacerbations of chronic bronchitis. | 2009 | 2886848 | |
| spontaneous oscillation of the systemic arterial pressure during cardiopulmonary bypass in man. the effects of some drugs used during the operation. | despite the fact that the blood flow maintained during cardiopulmonary bypass is rather steady in the extracorporeal pump output, the arterial pressure under high-dose fentanyl anaesthesia quite often shows sinusoidal oscillations. in the present study the duration of an oscillatory cycle was on average 17.6 +/- 3.6 s, its amplitude 7.3 +/- 1.6 mm hg and mean systemic arterial pressure 75 +/- 12 mm hg. the oscillation is affected by the drugs used under bypass conditions. in our series of clinic ... | 1987 | 2886117 |
| involvement of cell envelope components in the pathogenesis of vibrio cholerae: targets for cholera vaccine development. | parenteral cholera vaccines have for some years been removed from the who recommendations. with a greater understanding of the immunology of gut infections has come the realization that oral vaccines are the most promising approach. there are several possible approaches: killed vaccines, attenuated vibrio cholerae and true recombinants in which v. cholerae protective antigens are introduced into suitable carrier strains. this latter approach has perhaps greater potential as a carrier strain can ... | 1987 | 2885982 |
| a dot immunobinding assay (dia) on nitrocellulose membrane for the serological detection of antibodies to entamoeba histolytica. | a rapid, cheap, simple and specific serological test of adequate sensitivity for detecting igg antibodies against entamoeba histolytica antigen is described. axenically cultured amoebic antigen was used to precoat the nitrocellulose membrane. the strips were incubated with test samples and later with horseradish peroxidase (hrpo) labelled protein-a conjugate. a dark blue spot was obtained by treatment with peroxidase substrate, 4-chloro-1-naphthol, in positive samples. serum samples from 32 heal ... | 1986 | 2885949 |
| [correction of hemodynamics in patients with acute pneumonia]. | patients with acute pneumonia demonstrate disturbance of myocardial contractility manifesting itself in an increase of end diastolic and systolic volumes, a decrease in the ejection fraction and circular myocardial contractility rate. in a raised level of mean arterial pressure i.v. administration of strophanthin in acute pneumonia can produce a negative effect in the form of a decrease in the stroke volume and cardiac output. myofedrin promotes an increase in cardiac ejection and can be used fo ... | 2010 | 2885934 |
| [salazosulfapyridine or 5-aminosalicylic acid]. | 2010 | 2885762 | |
| ru 486 administration in a child with cushing's syndrome. | 2009 | 2885668 | |
| molecular evolution and nucleotide sequences of the maize plastid genes for the alpha subunit of cf1 (atpa) and the proteolipid subunit of cf0 (atph). | the nucleotide sequences of the maize plastid genes for the alpha subunit of cf1 (atpa) and the proteolipid subunit of cf0 (atph) are presented. the evolution of these genes among higher plants is characterized by a transition mutation bias of about 2:1 and by rates of synonymous and nonsynonymous substitution which are much lower than similar rates for genes from other sources. this is consistent with the notion that the plastid genome is evolving conservatively in primary sequence. yet, the mo ... | 1987 | 2885245 |
| synthesis of p-nitrophenyl 5-acetamido-3,5-dideoxy-alpha-d-glycero-d-galacto-2-nonulopyranosid onic acid, a chromogenic substrate for sialidases. | 1987 | 2885090 | |
| two distinct mechanisms for regulation of gamma-glutamyl transpeptidase in cultured rat hepatocytes by glucocorticoid-like steroids. | adult rat hepatocytes maintained in primary monolayer culture with defined medium were used to characterise two effects of glucocorticoid-like steroids in regulating gamma-glutamyltranspeptidase (ggt). low concentrations of glucocorticoids alone had little effect on ggt but synergistically enhanced induction of the enzyme by liver tumor-promoting xenobiotics such as 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)-ethane (ddt) and hexachlorocyclohexane. the enhancing effect appears to be mediated by the ... | 1987 | 2885003 |
| antihypertensive, hemodynamic and autonomic profile of a new angiotensin converting enzyme inhibitor, sch 33844 (spirapril). | sch 33844 is a new, potent and long-acting inhibitor of angiotensin converting enzyme (ace). antihypertensive, hemodynamic and autonomic actions of sch 33844 were examined in the present series of experiments. oral administration of 0.3-30 mg/kg reduced blood pressure of spontaneously hypertensive rats. the magnitude of the response was significantly enhanced by pretreatment of the animals with hydrochlorothiazide. blood pressure remained significantly depressed 24 hr following doses of 3 and 10 ... | 1987 | 2884941 |
| junior doctors' hours: a 60-hour week is a real possibility. | 2010 | 2884423 | |
| first-trimester prenatal diagnosis for huntington's disease with dna probes. | polymorphic dna probes linked to the locus for huntington disease (hd) were used for prenatal diagnosis of a 10-week fetus at 25% risk for the disease. the fetus proved to have a 48% risk of having inherited the hd mutation which was similar to that for the at-risk parent (50%). on this basis the parents elected to terminate the pregnancy. when appropriate family members are available and dna studies are informative, prenatal diagnosis of hd with polymorphic dna probes can determine the at-risk ... | 2010 | 2884412 |
| safety and efficacy of a recombinant dna plasmodium falciparum sporozoite vaccine. | a recombinant dna plasmodium falciparum sporozoite vaccine produced in escherichia coli (fsv-1) was tested in doses of 10 micrograms to 800 micrograms protein in fifteen volunteers. no serious adverse reactions occurred. antibodies that reacted with p falciparum sporozoite antigens by enzyme-linked immunoassay developed in twelve of the volunteers. the highest antibody titres induced were similar to those resulting from lifelong natural exposure to sporozoite-infected mosquitoes. postimmunizatio ... | 1987 | 2884410 |
| effect of isotretinoin on survival of patients with myelodysplastic syndrome. | 2010 | 2884408 | |
| thiols in oxidative phosphorylation: thiols in the f0 of atp synthase essential for atpase activity. | it was shown previously that the atp synthase complex of bovine heart mitochondria contains an essential set of thiols or dithiols in its membrane sector (f0), whose modification by various reagents results in uncoupling [yagi, t., and hatefi, y. (1984) biochemistry 23, 2449-2455]. the sensitivity to modifiers was increased by membrane energization, and the uncoupling was reversed by membrane-permeable thiol compounds when modifiers other than alkylating agents were used to uncouple. the present ... | 1987 | 2883930 |
| polyester film as an advantageous tool for light and ultrastructural examination of single cells infected with viruses. | the use of marked transparent polyester film as a support of cell monolayer, smears or sections (cryostat or paraffin), makes possible to examine the same cell preselected in the light microscope by electron microscope (em). consequently, this technique enables to use histological or immunohistological investigations (using immunofluorescence or peroxidase (px) labelling) by light microscopy before examination in em. as example we used herpes simplex virus (hsv) type 1-infected cells grown on th ... | 1987 | 2883863 |
| a competitive receptor binding radioassay for beta-1 and beta-2 adrenergic agents. | a rapid and sensitive competitive receptor binding assay for beta-1 and beta-2 adrenergic binding for adrenergic agents has been developed. the steps that are critical for the success of the assay are given in detail so that the assay can be set up in any routine laboratory with relative ease. the rationale behind the use of specific reagents is discussed. the assay requires microgram quantities of test compound, a radiolabeled specific beta adrenergic antagonist [3h]dihydroalprenolol (dha), and ... | 1987 | 2883662 |
| use of phoa gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin. | the transposon tnphoa was used to generate fusions between phoa, the gene for alkaline phosphatase (phoa), and genes encoding proteins that are secreted by vibrio cholerae. one of the phoa+ mutants isolated showed a dramatic reduction in its ability to colonize the intestines of suckling mice. this mutant no longer produced a 20.5-kda protein (tcpa) that we show is the major subunit of a v. cholerae pilus. amino-terminal sequence analysis of the tcpa pilus subunit showed that it shares amino aci ... | 1987 | 2883655 |
| comparison of the effects of fe2+ and cu2+ on prostaglandin synthesis in rabbit kidney medulla slices. | the effects of fe2+ and cu2+ on the generation of medullary prostaglandins e2 and f2 alpha have been compared. fe2+ markedly promoted the lipid peroxidation of rabbit kidney medulla slices. the lipid peroxidation induced by fe2+ inhibited both prostaglandin e2 and prostaglandin f2 alpha formation to a similar extent. while cu2+ produced only a small increase in lipid peroxidation, it had a powerful inhibitory effect on prostaglandin e2 formation. simultaneously, prostaglandin f2 alpha production ... | 1987 | 2883291 |
| recent advances in the neurochemistry of alzheimer's disease. | this article reviews recent progress in research in the genesis of neurochemical changes in the alzheimer brain, which has been primarily in two areas: the cellular proteins associated with the pathologic structures and the neurotransmitter changes. research and clinical implications of recent studies and of works in progress are provided. | 2010 | 2883177 |
| glutathione metabolizing enzyme activities in human thyroid. | glutathione peroxidases, glutathione transferase, glutathione reductase and gamma-glutamyl transpeptidase activities were analyzed in human thyroid tissues obtained from 17 patients undergoing resectional surgery because of a malignancy. it was deduced, from measurements of glutathione peroxidase activity with both h202 and cumene hydroperoxide, that thyroid contains only the selenium enzyme. the absence of selenium independent glutathione peroxidase activity in thyroid was confirmed with gel fi ... | 1987 | 2883074 |
| detection of 3-deoxy-2-octulosonic acid in thiobarbiturate-negative endotoxins. | 1987 | 2882849 | |
| bw a575c, a chemically novel agent with angiotensin converting enzyme inhibitor and beta-adrenoceptor-blocking properties. | bw a575c (n-(1-(s)-carboxy-5-[4(3-isopropylamino-2-(r, s)-hydroxypropoxy)indole-2- carboxamido]pentyl)-(r, s)-alanyl-(s)-proline) is a chemically novel agent which exhibits in a single molecule both angiotensin converting enzyme (ace) inhibition and beta-adrenoceptor-blocking properties. bw a575c produced a competitive blockade of heart rate responses to isoprenaline in a guinea-pig right atrial preparation (pkb 7.18 +/- 0.05, cf. pindolol 8.9 +/- 0.7). bw a575c inhibited a partially purified pr ... | 1987 | 2882805 |
| effects of 5-hydroxy-propafenone in guinea-pig atrial fibres. | the effects of 5-hydroxy-propafenone (5-oh-p), an active metabolite of propafenone, were studied on isolated atrial muscle fibres obtained from non-treated guinea-pigs and from animals pretreated with 5-oh-p, 3 mg kg-1, for 28 days. in untreated atria 5-oh-p, 10(-8) m-10(-4) m, produced a dose-dependent decrease in amplitude and df/dtmax and reduced the amplitude of the slow contractions induced by isoprenaline and histamine in high k+ media. 5-oh-p also produced a dose-dependent decrease in atr ... | 1987 | 2882804 |
| effects of 5-hydroxy-propafenone in guinea-pig atrial fibres. | the effects of 5-hydroxy-propafenone (5-oh-p), an active metabolite of propafenone, were studied on isolated atrial muscle fibres obtained from non-treated guinea-pigs and from animals pretreated with 5-oh-p, 3 mg kg-1, for 28 days. in untreated atria 5-oh-p, 10(-8) m-10(-4) m, produced a dose-dependent decrease in amplitude and df/dtmax and reduced the amplitude of the slow contractions induced by isoprenaline and histamine in high k+ media. 5-oh-p also produced a dose-dependent decrease in atr ... | 1987 | 2882804 |
| autonomic nervous control of fundic secretion of somatostatin and antral secretion of gastrin and somatostatin in pigs. | by selective catheterization of gastric veins, we studied the secretion of gastrin and somatostatin from the antrum and of somatostatin from the gastric fundus-corpus region in anaesthetized pigs with or without acute adrenalectomy. the secretion was studied during electrical stimulation of the vagus nerves and the splanchnic nerves and simultaneous irrigation of gastric lumen with fluids of high, low, and neutral ph. the corpus-fundus somatostatin response to vagal stimulation was biphasic with ... | 1987 | 2881824 |
| when to operate on open angle glaucoma. | the aim of treatment in primary angle glaucoma should be to reduce the intraocular pressure throughout the 24 hours to a level where no damage is done to the optic nerve head, thus preventing any field defect. open angle glaucoma as it is presently defined requires a significantly raised intraocular pressure to be associated with detectable changes in the optic nerve and a consequent visual field defect. the goal is therefore unattainable whilst this definition remains. the best that can be achi ... | 2010 | 2881812 |
| phosphoenolpyruvate carboxykinase as a selective indicator of ochratoxin a induced nephropathy. | 1986 | 2881768 | |
| a comparative study of high affinity choline uptake and choline utilization in cholinergic and non-cholinergic tissues. | comparative studies of [3h]choline accumulation were done in the limulus corpora pedunculata, abdominal ganglia and cardiac ganglion. dual uptake processes for choline were found in all three tissues. in acute experiments, the corpora pedunculata high affinity choline uptake system showed exclusive sensitivity to ouabain. prolonged exposure to ouabain revealed that the hachus of all three tissues were significantly inhibited. the metabolism of [3h]choline transported via the high affinity proces ... | 2010 | 2881705 |
| glucose intolerance in thyrotoxicosis roles of insulin, glucagon and somatostatin. | the responses in plasma glucose, insulin, c-peptide, glucagon and somatostatin to an oral glucose load were studied in 10 thyrotoxic patients and 10 matched euthyroid controls. the thyrotoxic patients had higher mean fasting plasma glucose (p less than 0.05) and responded to oral glucose with an earlier peak at 30 min which was higher than the corresponding glucose level in the controls (p less than 0.05). impaired glucose tolerance was found in 3 patients. fasting insulin and c-peptide levels w ... | 2010 | 2881418 |
| avaii polymorphism in the human ldl receptor gene. | 1987 | 2881256 | |
| [current data on insulin secretion and its regulation]. | glucose is the main stimulator and physiological regulator of insulin secretion. the great sensitivity of the b cell to glucose variations between 1 g/l (5.5 mm) and 3 g/l (16.6 mm) and its rapid response ensure the constant adaptation of its secretion to plasma glucose level. the cellular mechanisms involved in insulin response can be schematically represented in three stages: the first stage is the recognition of the insulinotropic agent. in the case of glucose, this involves its metabolism. t ... | 2010 | 2881028 |
| differential effect of growth factors on growth stimulation and phenotypic stability of glutamine-synthetase-positive and -negative hepatocytes in primary culture. | in rat liver parenchyma, two subpopulations of hepatocytes can be distinguished by the absence or presence of the marker enzyme, glutamine synthetase (gs). hepatocytes in the perivenous zone immediately adjacent to the hepatic venules in the liver acinus are positive for gs. using autoradiography in combination with immunocytochemistry, the response of these two hepatocyte populations (gs positive and gs negative) to a variety of growth factors (defined compounds or complex stimuli) was investig ... | 1986 | 2880778 |
| 1,4-dithiothreitol-induced changes in histamine h1-agonist efficacy and affinity in the longitudinal smooth muscle of guinea-pig ileum. | the effect of 1,4-dithiothreitol (dtt) on histamine h1-receptor agonist affinity and efficacy has been investigated in longitudinal muscle strips of guinea-pig ileum. exposure of ileal smooth muscle to dtt significantly increased the maximal responses to the partial agonists skf71473 and de-2pea, indicative of an increase in agonist efficacy. this effect was paralleled by a small decrease in ec50 values. in contrast, dtt produced a parallel displacement of the concentration-response curve to the ... | 1987 | 2880626 |
| 1,4-dithiothreitol-induced changes in histamine h1-agonist efficacy and affinity in the longitudinal smooth muscle of guinea-pig ileum. | the effect of 1,4-dithiothreitol (dtt) on histamine h1-receptor agonist affinity and efficacy has been investigated in longitudinal muscle strips of guinea-pig ileum. exposure of ileal smooth muscle to dtt significantly increased the maximal responses to the partial agonists skf71473 and de-2pea, indicative of an increase in agonist efficacy. this effect was paralleled by a small decrease in ec50 values. in contrast, dtt produced a parallel displacement of the concentration-response curve to the ... | 1987 | 2880626 |
| selectivity and sensitivity improvements at perfluorinated ionomer/cellulose acetate bilayer electrodes. | 2009 | 2880527 | |
| enhancer binding proteins predicted by informational spectrum method. | enhancer sequences analysed using the informational spectrum method (ism) show a characteristic frequency at .0488. it has been shown that the characteristic frequency for some dna binding proteins overlaps the characteristic frequency of their target dna sequences. we suggest here that two types of proteins, homeoproteins and the glucocorticoid receptors, might bind to enhancer sequences. | 2010 | 2879540 |
| phenotypic modification of human glioma and non-small cell lung carcinoma by glucocorticoids and other agents. | glucocorticoids are cytostatic for human glioma grown at a high cell density in cell culture. the effect is not cytotoxic, appears to involve a modification of the cell surface, and has been detected with methyl prednisolone, dexamethasone, and beta-methasone. glucocorticoids were also found to reduce malignancy-associated properties (plasminogen activator and endothelial mitogenesis) and enhance differentiation (glutamyl synthetase activity and high affinity gaba uptake). cytostasis was also se ... | 1986 | 2879508 |
| analysis of sialidase and n-acetylneuraminate pyruvate-lyase substrate specificity by high-performance liquid chromatography. | a rapid and sensitive assay by high-performance liquid chromatography for determination of the activity and substrate specificity of sialidase (ec 3.2.1.18) and n-acetylneuraminate lyase (ec 4.1.3.3) is described. sialic acids were separated on a strong anion-exchange resin using 0.75 mm sodium sulfate as elution medium. this method allows the determination of a minimum amount of 200 pg (0.6 pmol) of sialic acid. usually the enzyme mixtures were directly applied to the column without prior purif ... | 1986 | 2879483 |
| [treatment tactics in fractures of the midfoot]. | metatarsal fractures can occur as isolated lesions in combination with injuries of the ipsilateral tarsus, or in chain injuries of the lower extremity, or within a polytrauma. the choice of surgical or conservative therapy depends significantly on localisation and dislocation of the fracture (especially the involvement of the metatarsus i or v), as well as on the extent of the primary or expected soft part damage. from 1974 to 1984, 137 patients with metatarsal fractures were treated as in patie ... | 2010 | 2879425 |
| spatial distribution of langerhans' cells and t-lymphocyte subpopulations in human tympanic membrane and aural cholesteatoma. | immunohistochemical analysis of human cholesteatoma matrices revealed the presence of langerhans' cells and t-lymphocytes. through cell-to-cell interaction, langerhans' cells probably play a key role in skin-related disorders, including cholesteatomas. they probably originate from a mobile cell population of monocyte origin and migrate into and out of the body's lining. their custodial function is often carried out in close relation with t-lymphocytes. monoclonal antibodies against langerhans' c ... | 1986 | 2878530 |
| [advances in neurology]. | 2010 | 2878493 | |
| yellow fever in africa. | 2010 | 2878180 | |
| an outbreak of nosocomial cholera in a rural bangladesh hospital. | at a time of year when vibrio cholerae infection accounted for over 50% of admissions to a rural bangladeshi diarrhoea treatment centre, 29% of 48 patients hospitalized with non-cholera diarrhoea developed nosocomial v. cholerae infection. during an investigation of the 8-week outbreak, only the severity of the non-cholera diarrhoea which prompted hospital admission emerged as an important risk factor for nosocomial infection; food, intravenous solutions, oral rehydration fluid, patient attendan ... | 1986 | 2878033 |
| brown adipose tissue thermogenesis, torpor, and obesity of glutamate-treated mice. | mice treated with glutamate in the neonatal period are known to develop into stunted obese adults, despite hypophagia. our objective was to find out whether brown adipose tissue (bat) thermogenic function might be abnormal in the glutamate-obese mouse. at 10 wk of age, group-housed glutamate-obese mice exhibited nocturnal and early diurnal torpor, i.e., they thermoregulated at a lower than normal body temperature. when exposed to 4 degrees c, they died in hypothermia within 24 h. they could adap ... | 1986 | 2876642 |
| the neuropathology of aids. ucla experience and review. | the central nervous system (cns) has been examined at autopsy in 89 patients who died of the acquired immune deficiency syndrome (aids), including 14 patients who died primarily of neurologic complications of the disease. a total of 66 brains (74%) showed significant pathologic abnormalities, with opportunistic infections including cytomegalovirus (14) and cryptococcal (11) infections, progressive multifocal leukoencephalopathy (6), toxoplasmosis (6), and histoplasma microabscesses (1). incident ... | 1986 | 2876640 |
| reduction of pituitary size by the somatostatin analogue sms 201-995 in a patient with an islet cell tumour secreting growth hormone releasing factor. | acromegaly is rarely caused by the ectopic secretion of growth hormone releasing factor (grf) from peripheral neuroendocrine tumours. we evaluated the ability of a recently developed somatostatin analogue (sms 201-995, sandoz) to reduce hormone levels and pituitary size in a young woman with acromegaly and zollinger-ellison syndrome secondary to a metastatic pancreatic islet cell tumour secreting grf and gastrin. gastrin, grf, and growth hormone (gh) levels declined dramatically following the in ... | 2010 | 2876570 |
| [neuropharmacologic analysis of the process of developing extinctive inhibition in the lobectomized cat]. | pharmacological action on cholinergic and monoaminergic brain structures in the process of food-procuring reflex extinction was studied in intact and lobectomized cats. growing stimulation of cholinergic structures of lobectomized animals caused consecutive behavioural changes similar to those appearing during development of active reaction of intact animals to cancellation of the reflex reinforcement. in both cases influences on monoaminergic systems produced analogous effects, but suppressing ... | 1986 | 2876562 |
| [regulation of gamma-glutamyltransferase activity and synthesis in animal tissues]. | 2010 | 2876560 | |
| [beta-adrenergic blockers]. | 2010 | 2876553 | |
| the fine structure of atypical ciliated cells in the human gastric epithelium. | gastric mucosa obtained from the body and pyloric portions of the human stomach were observed by light and transmission electron microscopy. ciliated cells were found in two of 18 subjects examined, one patient with gastric ulcer and the other one with gastric adenocarcinoma. the ciliated cells were found in epithelia at sites away from the main lesions. the tissues containing ciliated cells showed intestinal metaplasia combined with mild chronic gastritis in both cases. the epithelial layer fac ... | 1986 | 2876543 |
| [hemorrhagic fever with renal syndrome. a survey of zoonosis]. | 2010 | 2876539 | |
| directives, methods and suggestions for anti-ulcer drug therapy. | 2010 | 2876535 | |
| [intraventricular thrombosis and systemic thromboembolism following acute myocardial infarction--retrospective study of 709 patients]. | 2010 | 2876479 | |
| [prevention of the increase of exertional blood pressure in patients with borderline essential hypertension. comparative study of the effects of nifedipine and/or propranolol]. | 2010 | 2876475 | |
| [arterial hypertension in the aged]. | 2010 | 2876472 | |
| interaction of famotidine with rat liver microsomes, a study showing less inhibition of drug metabolism than with cimetidine. | interaction of famotidine with rat liver microsomes and its effect on drug metabolism in vitro were studied. famotidine interacted with liver microsomes obtained from untreated, phenobarbital-pretreated and 3-methylcholanthrene-pretreated rats to produce characteristic type ii spectral changes with peaks at 423-426 nm and troughs at 387-390 nm. the spectral dissociation constants were in the range of 0.84-0.94 mm. famotidine inhibited aminopyrine n-demethylase activity to a much lesser extent th ... | 1986 | 2876442 |
| stimulant action of ethanol on posttetanic potentiation of hindlimb monosynaptic reflexes. | 1986 | 2876435 | |
| [therapeutic consequences of glaucoma treatment with different beta blockers in patients with obstructive respiratory tract diseases]. | in patients in whom chronic obstructive bronchial disease and chronic glaucoma had been diagnosed, the most important ventilation parameters and intraocular pressures were investigated in a double-blind cross-over study. the airway resistance, the forced expiratory volume within the first second, the thoracic volume, and the mean expiratory flow in these patients exhibited significant differences after treatment with non-cardioselective beta-blocking agents, depending on the beta-receptor stimul ... | 2010 | 2876127 |
| cyclosporin and graft survival. | 2010 | 2875295 | |
| nonidentical expressions of multiple endocrine neoplasia, type i, in identical twins. | we studied 25-year-old hla- and blood group-identical male twins who had multiple endocrine neoplasia, type i (men i). at the time of initial examination, one twin (case 1) had epigastric pain and diarrhea; he was cushingoid in appearance. further evaluation revealed primary hyperparathyroidism, zollinger-ellison syndrome, cushing's disease, and hyperprolactinemia. immunostaining of a resected pituitary specimen demonstrated both prolactin and, to a lesser extent, growth hormone reactivity. the ... | 2010 | 2875227 |
| characterization of n-ethylmaleimide-sensitive proton pump in the rat kidney. localization along the nephron. | this study is aimed both at characterizing an atpase activity in rat kidney equivalent to the proton pump described in bovine kidney medulla and at localizing this enzyme along the nephron. membrane fractions isolated from kidney homogenates by differential and density gradient centrifugations were enriched 7-fold in atpase activity sensitive to n-ethylmaleimide (nem). these fractions also displayed atp-dependent proton transport. atpase activity and proton transport in vesicles had similar phar ... | 1986 | 2875072 |
| testosterone inhibition of tyrosine hydroxylase expression in the hypothalamic arcuate nucleus. | immunohistochemistry was used to detect tyrosine hydroxylase (th)-containing neurons in the hypothalamic arcuate nucleus in male rats. two weeks following castration, the number of th-positive cells was significantly greater than in intact controls. the castration-responsive th-positive cells were uniformly distributed throughout the mediolateral extent of the arcuate nucleus. treatment with testosterone significantly suppressed the castration response, whereas neither estradiol nor 5 alpha-dihy ... | 1986 | 2874533 |
| the accuracy of hysterosalpingography versus laparoscopy in evaluation of infertile women. | two hundred fifteen infertile women underwent hysterosalpingography (hsg) and laparoscopy. one hundred twenty-eight patients had bilaterally patent tubes on hysterosalpingography. thirty-one percent of these women had pelvic adhesions diagnosed by laparoscopy. eighty-seven women had either occluded tubes or suspected pelvic adhesions on hysterosalpingography. thirty-nine percent of these women had patent tubes without any pelvic pathology on laparoscopy. inaccurate diagnoses limit the value of h ... | 2010 | 2874076 |
| monoamines in tubero-hypophyseal structures of farm animals. | dopamine (da) and 5-hydroxytryptamine (5-ht) were measured in several regions of the pituitary gland of jersey steers, soay ewes and two breeds of pigs. the glands were collected from animals which had not been stressed and the amine concentrations were comparable to those found previously in the pituitary glands of laboratory animals. metabolites of both amines were present in the infundibulum, the pituitary stalk, the combined neural and intermediate lobe and the anterior lobe of all glands an ... | 1986 | 2873954 |
| lack of comparability of two automated blood pressure monitors in a hypertensive population. | two frequently used automated, blood pressure monitors, the arteriosonde and the dinamap, were compared with each other and with a standard mercury sphygmomanometer. fifteen patients with elevated blood pressure were studied: 5 were untreated, 5 received a diuretic alone, and 5 received a beta blocker alone. one hundred and twenty blood pressure measurements were taken from each subject with two different instruments (one on each arm) in a 2 (supine or standing position) x 2 (left or right arm) ... | 2010 | 2873912 |
| design of eyedropper tips for topical beta-blocking agents. | 2003 | 2873745 | |
| [causes of death and follow-up in life insurance. 5 years' study]. | 2010 | 2873492 | |
| fatal temazepam overdoses. | 2010 | 2873474 | |
| rigidity and fever in two psychotic patients. | 2010 | 2873146 | |
| interaction between insulin and counterregulatory hormones in control of substrate utilization in health and diabetes during exercise. | in summary, the appropriate balance of glucagon and insulin at the liver and the catecholamines and insulin in the periphery provide the most optimal balance of substrate fluxes to the working muscle. when the hormonal balance is perturbed such as is seen in diabetes or with glucagon suppression, or when the effect of a hormone is impaired such as with beta blockade, optimal substrate balance is lost. the effects of these hormones can be overridden by metabolic factors in muscle, as evidenced by ... | 1986 | 2873005 |
| pharmacology of terazosin. | terazosin is a quinazoline antihypertensive agent that is chemically similar to prazosin. the saturated furan ring of terazosin distinguishes these two compounds. terazosin (0.1 to 3.0 mg/kg) lowered blood pressure without increasing heart rate when given orally to spontaneously hypertensive rats. no tolerance was observed during five days of repeated oral administration. although equally efficacious in spontaneously hypertensive rats as its congener prazosin, terazosin exhibited a more gradual ... | 1986 | 2872801 |
| pharmacology of terazosin. | terazosin is a quinazoline antihypertensive agent that is chemically similar to prazosin. the saturated furan ring of terazosin distinguishes these two compounds. terazosin (0.1 to 3.0 mg/kg) lowered blood pressure without increasing heart rate when given orally to spontaneously hypertensive rats. no tolerance was observed during five days of repeated oral administration. although equally efficacious in spontaneously hypertensive rats as its congener prazosin, terazosin exhibited a more gradual ... | 1986 | 2872801 |
| the politics of genocide. | 2010 | 2872434 | |
| immunomodulation by bordetella pertussis: antiviral effects. | treatment of mice by intraperitoneal inoculation of pertussis vaccine or lipopolysaccharide extracted from b. pertussis will effect resistance to rabies virus, encephalomyocarditis virus, semliki forest virus, and herpes simplex virus. our previous observations indicated that treatment of c3h/hen (+/nu) and bdf1 mice with pertussis vaccine injected i.p. five days prior to a mouse adenovirus lethal dose i.p. challenge elicited resistance to clinical disease and death. susceptibility returned to a ... | 1985 | 2872109 |
| the adjuvant effect of pertussis endotoxin protein in modulating the immune response to cholera toxoid in mice. | endotoxin protein represents a group of immunobiologically active p polypeptides which are associated with the lipopolysaccharide endotoxin in the outer membrane of gram-negative bacteria. to study the adjuvant effect of endotoxin protein, cf-1 mice were immunized intraperitoneally with graded doses of glutaraldehyde-inactivated cholera toxoid with and without endotoxin protein prepared from bordetella pertussis, salmonella typhi or vibrio cholerae. immune responsiveness was assessed by measurin ... | 1985 | 2872108 |
| differences in haemodynamic response to beta-blocking drugs between stable coronary artery disease and acute myocardial infarction. | theoretically the increased sympathoadrenal activity following acute myocardial infarction might augment the haemodynamic impact of beta-adrenoceptor blockade. to evaluate this question 32 haemodynamic studies were performed to compare the effects of equivalent beta-blocking doses of propranolol (8 mg i.v.) and pindolol (0.8 mg i.v.) in patients with a recent acute myocardial infarction (a.m.i.) or stable coronary artery disease (and a presumptive low sympathetic state). in stable coronary arter ... | 2010 | 2872054 |
| role of sialic acid in cell receptors for vesicular stomatitis virus. | the role of sialic acid in the receptors for vesicular stomatitis virus (vsv) was investigated by treating chick embryo related (cer) cells and goose erythrocytes with neuraminidases from different sources and studying the effects produced on both infection and haemagglutination. the virus attachment to cer cells was reduced by their treatment with c. perfringens and a. ureafaciens neuraminidases and the susceptibility to viral infection of desialylated cer cells was recovered by coating with ga ... | 1986 | 2871728 |