Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| immunogenicity of two formulations of oral cholera vaccine comprised of killed whole vibrios and the b subunit of cholera toxin. | two formulations of oral cholera vaccine were evaluated for safety and immunogenicity in adult volunteers in thailand, an area with sporadic cholera outbreaks. one formulation consisted of 2 x 10(11) killed vibrios and 5 mg of cholera toxin b subunit, as was previously evaluated in north american volunteers, and the other consisted of 1 x 10(11) killed vibrios and 1 mg of b subunit, as was recently evaluated in a field trial in bangladesh. three doses of each formulation were given with citrate- ... | 1989 | 2909484 |
| abortive replication of choleraphage phi 149 in vibrio cholerae biotype el tor. | choleraphage phi 149 adsorbed irreversibly to vibrio cholerae biotype el tor cells, and 50% of the injected phage dna bound to the cell membrane. although no infectious centers were produced at any time during infection, the host macromolecular syntheses were shut off and the host dna underwent chloramphenicol-inhibitable degradation. synthesis of monomeric phage dna continued similar to that observed in the permissive host. however, the concatemeric dna intermediates produced were unstable and ... | 1989 | 2908925 |
| neuropeptide-dopamine interactions. iii. cyclo(his-pro) and persistence of dopaminergic supersensitivity on withdrawal from one year continuous neuroleptic treatment. | when rats are given dopaminergic antagonists (neuroleptics) continuously for several days behavioral supersensitivity to dopaminergic agonists results. this supersensitivity, however, declines rapidly on neuroleptic withdrawal. the data presented here, however, are the first to show that the supersensitivity persists for a longer duration (greater than 100 days) if the neuroleptic is administered continuously for 1 year. oral administration of 0.76 +/- 0.13 mg/kg/day cyclo(his-pro), a peptide ex ... | 1988 | 2908706 |
| recent preclinical studies on neurotransmitter function after ecs. | 2010 | 2908676 | |
| subunit structure and enzymic activity of pertussis toxin. | pertussis toxin, an adp-ribosylating toxin, interacts with vertebrate cells of many types and inhibits the ability of these cells to respond to certain hormones and neurotransmitters, resulting in a multitude of biological effects. the structure and mechanism of action of this toxin are described. | 1988 | 2908558 |
| naloxone, but not tyr-mif-1, reduces volitional ethanol drinking in rats: correlation with degree of spontaneous preference. | the possible relationship between the actions of ethanol and opiates led us to examine the effect of opiate antagonists on ethanol intake in rats with a free choice of water. naloxone (nal) significantly reduced intake of ethanol. this effect was much greater in "high-preferring" (ethanol/total fluid intake greater than 60%) than in "low-preferring" (ethanol/total fluid intake less than 30%) rats. furthermore, a correlation was found between the degree of spontaneous preference (ethanol/total fl ... | 1988 | 2908062 |
| the androgenicity of progestational agents. | androgenic potency of the progestational component in oral contraceptives (ocs) is difficult to assess. all the 19-nor testosterone progestogens in oc formulations basically have similar potencies and androgenic activities with the exception of norgestrel (ng). ng is the most potent and androgenic of these agents. it is five to ten times as potent as norethindrone (net); levonorgestrel (1-ng), one of the two isomers of ng and the one responsible for its potency, is ten to 20 times more potent th ... | 2009 | 2908040 |
| [genes for enzymes of glutathione biosynthesis]. | 2008 | 2907942 | |
| [purification and characterization of vibrio parahaemolyticus pili isolated from a patient with diarrhea: comparative studies with vibrio cholerae o1 pili]. | 1988 | 2907917 | |
| [comparative characteristics of the hemodynamic and antianginal actions of obzidan and albetol in patients with stenocardia]. | 2009 | 2907700 | |
| early intravenous beta-adrenoceptor blockade for victims of heart attack. | 2009 | 2907695 | |
| eukaryote membrane genetics: the fo sector of mitochondrial atp synthase. | 1988 | 2907692 | |
| chronic cocaine enhances defensive behaviour in the laboratory mouse: involvement of d2 dopamine receptors. | c57bl/6 male mice injected with a challenge dose (20 mg/kg) of cocaine 72 h after the end of chronic intermittent treatment with the psychostimulant (two daily injections of 20 mg/kg for 10 days) exhibited a clear-cut increase in defensive upright and sideways postures and escape when confronted with a non-drugged conspecific. treated mice spent 40% of time showing defensive acts over the 5-min testing session. administration of the selective d2 receptor antagonist (-)-sulpiride (25 mg/kg) befor ... | 1988 | 2907661 |
| changes in the metabolic profile of the equine gluteus medius as a function of sampling depth. | 1. cross sections from the middle of the gluteus medius were removed from 10 adult horses and used to evaluate changes in histochemically determined muscle fiber type and biochemically determined metabolic enzyme activities as a function of sample depth. 2. muscle fiber types determined using histochemical methods for myosin atpase (ph 9.4) and succinic dehydrogenase (sdh) activity indicated percent fast-twitch glycolytic (fg) muscle fibers decreased and slow-twitch oxidative (so) fibers increas ... | 1988 | 2907449 |
| malaria as anthropo-ecosystem. part i: general concept. | 1988 | 2906647 | |
| metabolism of lovastatin by rat and human liver microsomes in vitro. | the metabolism of lovastatin (mevacor) was examined using isolated microsomes derived from the livers of normal and phenobarbital-treated rats and from human liver samples. incubation of lovastatin with rat liver microsomes resulted in the formation of several polar metabolites of lovastatin. the metabolites were isolated by hplc and identified by nmr and mass spectrometry. one fraction consisted of a 2:1 mixture of 6-hydroxy-lovastatin and the rearrangement product delta 4,5-3-hydroxy lovastati ... | 1988 | 2906589 |
| [an operative case of multiple endocrine neoplasia type 1 (men type 1) with insulinoma]. | 2009 | 2906375 | |
| pharmacological properties of the positive inotropic and alpha 1-adrenoceptor blocking agent saterinone. | the pharmacological properties of saterinone [+/-)-1,2-dihydro-5-[4-[2-hydroxy-3-[4-(2-methoxyphenyl)-1-piperazinyl] propoxy]phenyl]-6-methyl-2-oxo-3-pyridine-carbonitrile, bdf 8634) were investigated in isolated organs of the guinea pig and in human platelets. saterinone was found to be a potent antagonist at vascular alpha 1-adrenoceptors with a pa2-value of 8.46 +/- 0.12. besides its affinity for alpha 1-adrenoceptors saterinone exerted a positive inotropic effect in the isolated papillary mu ... | 1988 | 2906245 |
| production of pili on vibrio parahaemolyticus. | electron microscopic examination showed that all strains of vibrio parahaemolyticus examined had pili on their surface when the organism was grown on marine agar at 28 degrees c for 6-12 h. the pili were morphologically stable on heat treatment at 60 degrees c for 10 min, but both the lateral and polar flagella possessed by this organism were labile. no immunological cross-reactivity between pili of enterotoxigenic escherichia coli and vibrio cholerae non-01 and those of v. parahaemolyticus was ... | 1988 | 2905206 |
| the sequential sampling of psorophora columbiae larvae in rice fields. | sequential sampling plans were developed for larval populations of psorophora columbiae developing in rice fields during the growth of rice for a 2nd crop in southwestern louisiana. two types of plans were developed: 1) sequential counting plans to estimate the true mean of a population with a prespecified coefficient of variation and 2) sequential decision plans to assist in deciding whether the mean larval count/dip lies outside preselected upper or lower levels. the procedure by which the pla ... | 2008 | 2904961 |
| family planning practice among nigerian student midwives. | an analysis of the various contraceptive methods practiced by a total of 462 student midwives from the northern and southern parts of nigeria over a 3-years period is presented. the differences in age distribution, the type of contraceptive agents used, the reasons for using them, and the side effects in the two groups are statistically significant. the need to provide acceptable contraceptive advice to the rural communities by the midwives is discussed. | 2010 | 2904908 |
| the pathogenesis and immunology of vibrio cholerae and bordetella pertussis. | 1988 | 2904796 | |
| morphological studies on fimbriae expressed by vibrio cholerae 01. | colonization of the small intestine is an essential step in the pathogenesis of vibrio cholerae diarrhea. at least one type of fimbriae, known as tcpa are required for the colonization process. this paper reports electron microscopic evidence that v. cholerae strains can express at least two other fimbrial types. classical strains express three types: tcpa fimbriae are 5-6 nm in diameter and form bundles of parallel undulating filaments up to 15 micron long; type b are 3 nm wide and of wavy morp ... | 1988 | 2904642 |
| clinical isolates of vibrio cholerae o1 not producing cholera toxin. | 1988 | 2904592 | |
| the organization of the cholinergic synapse. | 2010 | 2904504 | |
| maintenance of integrity, viability, and adhesion of entamoeba histolytica trophozoites in different incubation media. | we have determined the integrity, viability and adhesion of entamoeba histolytica hk9 and hm1 trophozoites during their incubation in two basal culture media (tp and tyi) and three saline media ("maintenance medium" mm-1 and two others buffered with hepes). in basal culture media, more than 70% of the trophozoites maintained their integrity and adhesion to human red blood cells (rbc) for up to 4 h, and the proportion of those excluding trypan blue decreased slowly after 2 h. in saline media, the ... | 1988 | 2904497 |
| genetic characterization and use of a restriction fragment length variant in the hypotrichous ciliate euplotes crassus. | two forms of a macronuclear dna molecule differing in the presence or absence of a restriction endonuclease recognition site have been detected in the hypotrichous ciliate euplotes crassus. through a series of genetic crosses the two forms were shown to be allelic, being derived from a single micronuclear genetic locus. this restriction fragment length variant (rflv) was used as a genetic marker to determine that the migratory and stationary pronuclei generated during mating can be genetically n ... | 2010 | 2904496 |
| ketamine blocks an nmda receptor-mediated component of synaptic transmission in rat hippocampus in a voltage-dependent manner. | we have examined the voltage dependence of the effects of ketamine on synaptic currents in hippocampal ca1 neurons in vitro under conditions where there is a large n-methyl-d-aspartate (nmda) receptor mediated component of the response. ketamine reduced inward currents to a greater extent than outward currents of a corresponding size. d-2-amino-5-phosphonovalerate (apv) substantially reduced the residual outward currents recorded in ketamine, but had only a small effect on the residual inward on ... | 1988 | 2903476 |
| coronary heart disease prevention. | 2010 | 2903393 | |
| abdominal wall defects and cryptorchidism: an animal model. | intra-abdominal pressure has been implicated in the mechanism of testicular descent. boys born with abdominal wall defects reportedly have an increased incidence of cryptorchidism. to examine this relationship further a rat model was developed. the rat testis normally descends postnatally on or about day 21. in this study newborn male rats underwent surgical excision of all anterior abdominal musculature from the umbilicus to the xiphoid, while a control group had a sham procedure. in both group ... | 1988 | 2903256 |
| apical membrane endocytosis via coated pits is stimulated by removal of antidiuretic hormone from isolated, perfused rabbit cortical collecting tubule. | antidiuretic hormone increases the water permeability of the cortical collecting tubule and causes the appearance of intramembrane particle aggregates in the apical plasma membrane of principal cells. particle aggregates are located in apical membrane coated pits during stimulation of collecting ducts with adh in situ. removal of adh causes a rapid decline in water permeability. we evaluated apical membrane retrieval associated with removal of adh by studying the endocytosis of horseradish perox ... | 1988 | 2903250 |
| antiallergy agents. 1. substituted 1,8-naphthyridin-2(1h)-ones as inhibitors of srs-a release. | a novel class of antiallergy agents, the substituted 1,8-naphthyridin-2(1h)-ones, is described. the present compounds are orally active, potent inhibitors of allergic and nonallergic bronchospasm in animal models. structure-activity studies of the lead compound in this series, 1-phenyl-3-n-butyl-4-hydroxynaphthyridin-2(1h)-one (11), identified three compounds of interest, 1-phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1h)-one (12), 1-(3'-chlorophenyl)-3-(2-propenyl)-4-acetoxy-1,8-naphthyri ... | 1988 | 2903244 |
| vibrio cholerae non-o1: production of cell-associated hemagglutinins and in vitro adherence to mucus coat and epithelial surfaces of the villi and lymphoid follicles of human small intestines treated with formalin. | clinically isolated vibrio cholerae non-o1 strains produced more cell-associated hemagglutinins (has) on colonization factor antigen agar after ca. 3 h than after ca. 20 h of incubation at 37 degrees c. a high cell-associated ha producer variant of strain tvn-318, grown for 3 h at 37 degrees c, was entrapped in a native mucus coat covering the human ileal mucosa and displayed a striking ability to adhere to the surface of a formalin-treated mucus coat, in contrast to a poor cell-associated ha pr ... | 1988 | 2903173 |
| vibrio cholerae o1 adherence to villi and lymphoid follicle epithelium: in vitro model using formalin-treated human small intestine and correlation between adherence and cell-associated hemagglutinin levels. | formalin-fixed human small intestinal mucosa possessing villi and lymphoid follicle epithelium of peyer's patches at the mucosal surface was used to test the adherence ability of clinically isolated strains of vibrio cholerae o1. v. cholerae o1 grown on cfa agar for approximately 3 h at 37 degrees c had various levels of cellular hemagglutinins (has) and manifested adherence abilities that were roughly correlated with the cellular ha levels, irrespective of cellular ha types. v. cholerae o1 adhe ... | 1988 | 2903129 |
| effect of oversulphated chondroitin and dermatan sulphate upon thrombin and factor xa inactivation by antithrombin iii or heparin cofactor ii. | the kinetics of inhibition of human thrombin and factor xa by antithrombin iii or heparin cofactor ii were examined under pseudo-first-order conditions as a function of the concentration of naturally occurring oversulphated chondroitin and dermatan sulphates. the sulphated glycosaminoglycans (gags) studied were chondroitin sulphate d (csd) (glca-2-so4-galnac-6-so4), chondroitin sulphate k (csk) (glca-3-so4-galnac-4-so4), chondroitin sulphate h (csh) (ida-galnac-4,6-diso4) and polysulphated derma ... | 1988 | 2902851 |
| toxin, toxin-coregulated pili, and the toxr regulon are essential for vibrio cholerae pathogenesis in humans. | isogenic mutant strains of v. cholerae o1 lacking elements of a genetic regulon controlled by toxr and implicated in virulence were tested in volunteers. a deletion mutation in ctxa, the gene encoding the a subunit of cholera toxin, markedly attenuated disease symptoms without affecting intestinal colonization. deletion of toxr, the gene encoding the cholera toxin-positive regulatory protein resulted in a diminution in colonizing capacity. a deletion mutation in tcpa, encoding the major subunit ... | 1988 | 2902187 |
| localization of plutonium retention in the small intestine of the neonatal rat, guinea pig, baboon and macaca after pu-citrate ingestion. | the retention of pu-citrate in the gastrointestinal wall was compared at similar post ingestion times after ingestion at 2 days of age by rats and guinea pigs and at 1 to 34 days by neonatal primates. the small intestine was the main site of the pu retention in all species. in rats and primates, most of the pu was retained in the distal ileum, whereas in guinea pigs it was more homogeneously distributed. in the rats, pu was retained in the epithelial cells on villi, but in the guinea pigs and pr ... | 1988 | 2902152 |
| characterization of the vibrio cholerae toxr regulon: identification of novel genes involved in intestinal colonization. | a gene fusion library of vibrio cholerae classical strain o395 was generated by using a broad host range vector for delivery of the transposon tnphoa. the insertion library was screened for colonies expressing alkaline phosphatase-positive (phoa+) fusion proteins on lb agar at 30 degrees c in the presence of 0.2% glucose. over 600 phoa+ strains were isolated and then tested for regulation of their gene fusions in broth media that permitted high or low expression of cholera toxin. this strategy r ... | 1988 | 2902009 |
| cloning and sequencing of a clostridium perfringens sialidase gene. | escherichia coli was transformed with puc vectors containing sau3a restriction fragments (rf) of clostridium perfringens dna. two clones expressed sialidase activity when assayed with the fluorogenic substrate 4-methylumbelliferyl-alpha-d-n-acetylneuraminic acid. a synthetic oligonucleotide representing the n-terminus of the expressed enzyme hybridized with the clostridial insert and with a corresponding 2.1 kb sau3a rf of the c. perfringens genome. the insert reduced to 1.4 kb, which still enco ... | 1988 | 2901987 |
| [new treatments of hemorrhagic rectocolitis]. | the treatment of ulcerative colitis has benefited from the development of new molecules (azo-disalicylates) or new galenic forms (pentasa, azacol...) permitting, via oral administration, to supply the colon with 5-aminosalicylic acid without the sulfapyridine with which it was combined in salazosulfapyridine and was responsible for most side effects. pentasa and steroids which are moderately absorbed by the colonic mucosa (tixocortol pivalate, prednisolone metasulfabenzoate may also be used un a ... | 2010 | 2901821 |
| dissociation-reconstitution experiments with nbd-modified f1: support for the presence of two catalytic beta-subunits. | 2010 | 2901754 | |
| haemophilia carrier detection using dna analysis. | 2010 | 2901705 | |
| pertussis toxin blocks the effects of alpha 2-agonists and antagonists on locus coeruleus activity in vivo. | this study assessed the effects of pertussis toxin, which is known to inactivate g proteins and therefore to block receptors linked to g proteins, on electrophysiological activity of the locus coeruleus in vivo. pertussis toxin was injected into the lateral cerebral ventricle of rats, and locus coeruleus activity was then recorded. compared to vehicle-injected control animals, pretreatment with pertussis toxin markedly increased the spontaneous firing rate of locus coeruleus neurons. in addition ... | 1988 | 2901703 |
| dopamine release in the nucleus accumbens of freely moving rats determined by on-line dialysis: effects of apomorphine and the neuroleptic-like peptide desenkephalin-gamma-endorphin. | this study examined the effects of apomorphine, sulpiride, desenkephalin-gamma-endorphin (de gamma e) and a combination of de gamma e with apomorphine on the release of dopamine (da) and its main metabolites 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the nucleus accumbens of freely moving rats. a fully automated on-line brain dialysis system was used. a small dose of s.c. administered apomorphine induced a decrease in the output of da and dopac. sulpiride, infused into ... | 1988 | 2901702 |
| a population of very small striatal neurons in the cat displays vasoactive intestinal polypeptide immunoreactivity. | cells displaying vasoactive intestinal polypeptide (vip) immunoreactivity were demonstrated in the feline striatum using a monoclonal antibody raised against natural porcine vip. the vip-immunoreactive neurons in the cat striatum were very small, (8 microns diameter) bipolar and multipolar cells. the vip-positive neurons were more numerous than the cholinergic neurons but less common than the somatostatin-immunoreactive cells in the cat caudate-putamen. the vip-immunoreactive cells were localize ... | 1988 | 2901699 |
| occurrence of pyroglutamyl peptidase ii, a specific trh degrading enzyme in rabbit retinal membranes and in human retinoblastoma cells. | pyroglutamyl peptidase ii, a highly specific thyrotropin releasing hormone (trh)-degrading enzyme is found in highest concentration in brain where it is localized to synaptic membranes. retina contains relatively high concentrations of both immunoreactive trh and trh receptors. we report that the specific activity of pyroglutamyl peptidase ii in rabbit retinal membranes exceeds that of all non-cns tissues thus far studied. nine clonal cell lines were screened for this enzymatic activity. the spe ... | 1988 | 2901687 |
| changes in neurotransmitter release at a neuromuscular junction of the lobster caused by cannabinoids. | in vitro intracellular recording techniques were used on an excitatory neuromuscular junction of a walking-limb stretcher muscle of the lobster in order to define the synaptic pharmacology of delta-9-tetrahydrocannabinol (thc), 11-hydroxy-thc and cannabidiol. delta-9-tetrahydrocannabinol and 11-hydroxy-thc, in relatively small concentrations, increased the amplitude of the excitatory junctional potential and the mean quantum content of a muscle fiber, whereas larger concentrations produced depre ... | 2010 | 2901683 |
| human herpesvirus 6 and the henle-koch postulates. | 1988 | 2901654 | |
| serum from the cotton rat (sigmodon hispidus) lacks lytic activity against some trypanosoma vivax stocks. short communication. | 1988 | 2901208 | |
| adult t cell leukemia presenting with proliferative synovitis. | 1988 | 2900640 | |
| the role of cloned genes in the prevention of genetic disease. | the application of recombinant dna technology to the study of human genetic disease promises to increase the scope for carrier detection and prenatal diagnosis. here we summarize current experience with prenatal diagnosis of single-gene disorders by dna analysis and highlight some of the technical and organizational problems that remain to be solved. | 1988 | 2900519 |
| safety, immunogenicity, and efficacy of recombinant live oral cholera vaccines, cvd 103 and cvd 103-hgr. | the genes encoding the a (toxic) subunit of cholera toxin were deleted from pathogenic vibrio cholerae o1 strain 569b by recombinant techniques, leaving intact production of immunogenic, non-toxic b subunit. the resultant strain, cvd 103, evaluated for safety, immunogenicity, and efficacy as a live oral vaccine, was highly attenuated and elicited strong antibacterial and antitoxic immune responses; a single dose significantly protected volunteers against challenge with pathogenic v cholerae o1 o ... | 1988 | 2900401 |
| inhibitory effect of glycyrrhetinic acid derivatives on arachidonic acid-induced mouse ear oedema. | the inhibitory effects of glycyrrhetinic acid and its derivatives were examined on arachidonic acid (aa)-induced ear oedema in mice. of the compounds, dihemiphthalate derivatives of 18 beta-olean-12-ene-3 beta, 30-diol (iid, iid'), 18 beta-olean-9(11)12-diene-3 beta, 30-diol (iiia, iiia') and olean-11, 13(18)-diene-3 beta, 30-diol (iva, iva') showed a strong inhibition of ear oedema on both tropical (id50, 1.9, 2.8 and 1.7 mg/ear, respectively) and oral (id50, 90, 130 and 88 mg kg-1, respectivel ... | 1988 | 2900308 |
| importance of pulmonary blood volume and aortic blood pressure in regulation of left ventricular function. | 1988 | 2900297 | |
| repair of potentially mutagenic damage, sensitive to anisotonic treatment, in actively growing chinese hamster cells. | using exponentially growing chinese hamster v79 cells we studied the effect of anisotonic phosphate-buffered saline (pbs) treatment on the frequency of mutation following x-irradiation. induction of mutants was studied at the hypoxanthine-guanine phosphoribosyl transferase locus (hgprt). when cells were x-irradiated and immediately followed by 0.5 m nacl/pbs treatment for 20 min at 37 degrees c, cell survival was significantly decreased and a concomitant increase in the number of mutants was obs ... | 2010 | 2900279 |
| binding of mouse red blood cells (mrbc) by human thymocytes: augmentation of rosette formation by phospholipase c treatment. | the formation of rosettes with mrbc is not an exclusive property of chronic lymphocytic leukemia cells and of human b-lymphocytes. human thymus cells and the hd-mar t-cell line were also found to be capable of forming rosettes with mrbc. the binding of mrbc by thymocytes differed from that of sheep (srbc), rabbit (rrbc) and human (hrbc) erythrocytes by a number of parameters: monoclonal antibodies against the e-receptor inhibited the attachment of srbc, rrbc, and hrbc, but not of mrbc to thymus ... | 1988 | 2900227 |
| detergent-accelerated hydrolysis of bacterial endotoxins and determination of the anomeric configuration of the glycosyl phosphate present in the "isolated lipid a" fragment of the bordetella pertussis endotoxin. | due to the formation of micelles, severance of the hydrophilic (poly- or oligosaccharide) and hydrophobic ("lipid a") domains of bacterial lipopolysaccharides at ph 3.4 or 4.5 and 100 degrees is slow and sometimes does not proceed at all; partially degraded fragments are usually formed. at ph 3.4 (100 degrees) in aqueous 1% sodium dodecylsulphate (sds), both lipopolysaccharides of the bordetella pertussis endotoxin are cleaved within 20-30 min, but 80% of the glycosidically bound phosphate prese ... | 1988 | 2900066 |
| safe, live vibrio cholerae vaccines? | mutants of vibrio cholerae defective in intestinal colonization have been constructed. characterization of these mutants has led to the identification of a gene cluster involved in the assembly of a pilus colonization factor called tcp. the tcp operon has been cloned and strains of v. cholerae have been constructed that overproduce this pilus and the b subunit of cholera toxin. together these studies may contribute to the eventual construction of efficient live and killed, oral cholera vaccines. | 1988 | 2898843 |
| impact of b subunit killed whole-cell and killed whole-cell-only oral vaccines against cholera upon treated diarrhoeal illness and mortality in an area endemic for cholera. | the impact of b subunit killed whole-cell (bs-wc) and killed whole-cell-only (wc) oral cholera vaccines was assessed in a randomised double-blind trial in rural bangladesh. 62,285 children aged 2-15 years and women aged over 15 ingested three doses of one of the vaccines or placebo. during the first year of follow-up there was a 26% reduction of all visits for treatment of diarrhoea in the bs-wc group and a 22% reduction in the wc group. the reduction of all admissions for fatal or severely dehy ... | 1988 | 2898052 |
| effects of psychotropic medications on hypothalamic-pituitary-adrenal regulation. | the psychotropic medications reviewed in this paper have widespread clinical applicability in psychiatry and other branches of medicine. these drugs clearly can alter peripheral regulation of hypothalamic-pituitary-adrenal axis hormones. in general, psychotropic medications when administered acutely have a tendency to increase the output of both adrenal and pituitary hormones associated with the axis; the benzodiazepines appear to be the exception and indeed may decrease axis activity. psychotro ... | 2010 | 2897911 |
| [parkinson disease. the clinical picture and therapy]. | 2010 | 2897901 | |
| mechanisms of altered hormone and neurotransmitter action during aging: the role of impaired calcium mobilization. | age-related changes in hormone and neurotransmitter regulation of physiological functions result from various mechanistic alterations. in many cases changes in the receptors for these agents appear to be closely linked to altered responsiveness. in other instances, receptors are unaffected by aging, and various post-receptor changes result in functional deterioration. examples of the latter situation include stimulation of cyclic amp production and high-affinity association of steroid receptor-h ... | 1988 | 2897815 |
| isolation and mapping of a polymorphic dna sequence (pynz32) on chromosome 4p [d4s125]. | 1988 | 2897672 | |
| rflp for taqi at the human neurofilament (nf-l) gene locus. | 1988 | 2897671 | |
| human taqi rflp recognized by neurofilament gene probes. | 1988 | 2897670 | |
| economic aspects of beta-blocker therapy following myocardial infarction. | 2010 | 2897465 | |
| involvement of prostaglandins in histamine-induced fluid and electrolyte secretion by rat colon. | histamine increased the transmural potential difference across rat colon in-vivo and induced a net secretion of fluid. both effects were inhibited by indomethacin. histamine increased the potential difference and short-circuit current, and reduced tissue resistance in colonic sheets in-vitro. this response was reduced in the absence of chloride in the bathing medium or in the presence of serosal frusemide, suggesting that histamine stimulated electrogenic chloride secretion by the colon. the ris ... | 1988 | 2897440 |
| [cryptococcal meningitis with human t-cell leukemia virus type i carrier: report of a case]. | 1987 | 2897417 | |
| induction of contrasuppression is restricted by genes mapping to the igh locus. | 2010 | 2897413 | |
| phenotypic and functional characterization of human contrasuppressor cell interactions. | 1988 | 2897409 | |
| [an immunological study of human t-cell leukemia virus type i (htlv-i) infection (ii)--radioimmunoprecipitation and sds-polyacrylamide gel electrophoretic analysis of antibody of carriers]. | 1987 | 2897404 | |
| pemphigus foliaceus-like, immunologically negative dermatosis in a patient with t cell chronic lymphocytic leukemia. | a 56-year-old black man developed a pemphigus foliaceus-like bullous eruption as the initial presentation of chronic t cell lymphocytic leukemia. histologic examination disclosed superficial acantholysis consistent with pemphigus foliaceus and an infiltrate of atypical lymphoid cells in the papillary dermis. repeated direct and indirect immunofluorescence studies yielded negative results. acantholysis could be reproduced in vitro by incubation of normal human skin with the patient's serum and pl ... | 1988 | 2897384 |
| supraspinal nocifensive responses of cats: spinal cord pathways, monoamines, and modulation. | these experiments were conducted to determine (1) whether dorsal and ventral ascending spinal pathways can each mediate unlearned supraspinal nocifensive responses of cats to noxious thermal stimuli and (2) whether interrupting the spinal projection of supraspinal monoaminergic neurons alters the excitability and natural modulation of these responses. in partially restrained cats, thermal pulses (greater than or equal to 47 degrees c) delivered to the hindlimbs of intact cats or rostral to lesio ... | 1988 | 2897383 |
| thin-layer chromatographic screening method for the tranquillizers azaperone, propiopromazine and carazolol in pig tissues. | a procedure is described for the detection of azaperone, propiopromazine and carazolol in pig muscle, liver and kidney tissue. the method comprises extraction from an alkaline tissue homogenate with diethyl ether, followed by cleaning up and concentration of the extract on a silica gel solid-phase extraction column. two-dimensional thin-layer chromatography on a silica plate was used for the detection of the tranquillizers. detection levels were 25 micrograms kg-1 for propiopromazine, 50 microgr ... | 1988 | 2897377 |
| fibronectin is a component of the sodium dodecyl sulfate-insoluble transglutaminase substrate. | liver plasma membranes contain a morphologically distinct protein complex which serves as a substrate for the plasma membrane-associated transglutaminase. the complex, which appears as a two-dimensional sheet, is insoluble in sodium dodecyl sulfate and reducing agents and has been named sits for sodium dodecyl sulfate-insoluble transglutaminase substrate (tyrrell, d. j., sale, w. s., and slife, c. w. (1988) j. biol. chem. 263, 1946-1951). polyclonal antibodies raised against sits were used to pr ... | 1988 | 2897368 |
| steroid regulation of somatostatin mrna in the rat hypothalamus. | the participation of gonadal steroid hormones in the regulation of the expression of the somatostatin gene in the hypothalamus and cerebral cortex was studied by using a quantitative densitometric hybridization assay which allows the direct measurement of specific somatostatin mrna levels. the levels of somatostatin mrna in hypothalamus were found to be significantly decreased following gonadectomy in both male and female rats (67% in males and 75% in females). moreover, with in situ hybridizati ... | 1988 | 2897361 |
| arylamine n-acetyltransferase from chicken liver ii. cloning of cdna and expression in chinese hamster ovary cells. | a cdna clone encoding the full coding region of chicken liver arylamine acetyltransferase (ec 2.3.1.5) was isolated from lambda gt10 cdna library by screening with the 32p-labeled oligonucleotide deduced from the amino acid sequence reported in the preceding paper. the complete nucleotide sequence of the cdna was determined, from which the amino acid sequence of n-acetyltransferase was deduced. it consisted of 1,302 nucleotides including a 861-nucleotide region coding for 287 amino acids with a ... | 1988 | 2897360 |
| use of ultrasonography to diagnose sertoli cell neoplasia and cryptorchidism in a dog. | unilateral cryptorchidism and sertoli cell tumor in the descended testis were provisionally diagnosed by use of ultrasonography in a 7-year-old keeshond. the left testis was thought to have degenerated, but ultrasonography of the scrotum did not reveal evidence of testicular or epididymal tissue. the contralateral testis contained a hypoechoic mass believed to be a testicular tumor. surgery and histopathologic findings confirmed the diagnosis. ultrasonography of the scrotum and its contents shou ... | 1988 | 2897351 |
| antimicrobial susceptibility of bordetella pertussis (part i). | in this review of the literature data are collected from the more recent studies on the susceptibility of bordetella pertussis to penicillins, cephalosporins, other beta-lactam antibiotics, aminoglycosides, tetracyclines, erythromycin, josamycin, co-trimoxazole and various other antibiotics. the methods of susceptibility testing of b. pertussis are discussed and suggestions for standardization are made. | 1988 | 2897337 |
| generation of l3t4-/ly-2- t cells in peyer's patches of mice treated with monoclonal antibody against helper t cells. | the effect of in vivo administration of anti-l3t4 monoclonal antibody on the generation of an l3t4-/ly-2- (cd4-/cd8-) population of thy-1.2+ cells was examined in peyer's patches of mice by two-color flow cytometry. female balb/c mice aged 8 wk were given 4-6 weekly injections of either anti-l3t4 (1 mg/wk) or phosphate-buffered saline (control group), and dispersed peyer's patch cells analyzed for the presence and absence of l3t4 and ly-2 on thy-1.2+ cells. in anti-l3t4 treated mice, l3t4-/ly-2- ... | 2010 | 2897329 |
| comparison of adrenal medullary, carotid body and pc12 cell grafts in 6-ohda lesioned rats. | the survival and functional properties of dispersed cell implants of catecholaminergic cells obtained from the peripheral nervous system of adult rats (adrenal medulla and carotid body glomus cells) and pc12 cells from a rat pheochromocytoma cell line were examined following transplantation into the striatum of the adult rat. the host animals, all with unilateral 6-hydroxydopamine (6-ohda) nigrostriatal lesions, were divided into 5 groups: (1) pc12 cells transplanted into cyclosporin-a treated h ... | 1988 | 2896533 |
| development of aids, hiv seroconversion, and potential co-factors for t4 cell loss in a cohort of intravenous drug users. | a cohort of 334 intravenous (iv) drug users from new york city drug treatment programs were followed over a mean 9-month period. among the 165 who were seropositive at enlistment, four developed clinical aids, for an annual rate of 3%. elevated iga was a significant predictor of developing aids. among 72 subjects who were initially seronegative and who were re-interviewed, four were seropositive at follow-up, for a seroconversion rate of 7% per year among seronegatives. among seropositive subjec ... | 1987 | 2896511 |
| x-linked lymphoproliferative disease: linkage studies using dna probes. | linkage studies have been carried out with 28 x-linked polymorphic probes to try to locate the gene for x-linked lymphoproliferative disease (xlp). dna from three families has been analysed, including three affected boys among 21 family members. none of the probes tested has been found to be linked to xlp. however, the data are recorded for the use of other workers on this rare disease. | 2010 | 2896078 |
| isolated duodenal tamponade for treatment of bleeding duodenal ulcer. | 2010 | 2895833 | |
| sex as a risk factor for htlv-i spread among intravenous drug abusers. | 1988 | 2895250 | |
| one-minute endoscopy room test for campylobacter pylori. | 1988 | 2895232 | |
| an outbreak of campylobacter jejuni infection in a neonatal intensive care unit. | 1988 | 2895144 | |
| dietary effects on initiation and promotion of hepatocarcinogenesis in rat. | female f344/n rats were initiated with den (10 mg/kg) 24 h after a 70% partial hepatectomy. groups of 10 rats were fed (a) ain, group-1; (b) pd, group-2; or (c) nih, group-3, for 1 week after initiation and were then fed nih plus the promoting agent pb at a level of 0.05% in the diets for 6 months. other groups were fed nih for 1 week after initiation and then nih without pb (group-4), ain + pb (group-5), ain without pb (group-6), pd + pb (group-7), or pd without pb (group-8) for 6 months. the n ... | 1988 | 2895112 |
| isms positions on aids and hiv antibody testing. | 1988 | 2895089 | |
| influence of bordetella avium infection on association of escherichia coli with turkey trachea. | four-week-old bordetella avium-infected and b avium-free turkeys were inoculated intratracheally with a suspension of fimbriated or nonfimbriated escherichia coli. numbers of e coli associated with tracheal sections were determined at postinoculation hour (pih) 1 or 6. significantly (p less than 0.05) greater numbers of e coli were isolated from the tracheas of b avium-infected turkeys compared with numbers in b avium-free turkeys. in b avium-free turkeys, tracheal associated e coli were 90% les ... | 1987 | 2893567 |
| [characteristics of the pharmacodynamics of alpha adrenergic receptor blockader pratsiol in various age groups]. | 2007 | 2892964 | |
| [characteristics of the pharmacodynamics of alpha adrenergic receptor blockader pratsiol in various age groups]. | 2007 | 2892964 | |
| identification of a pilus colonization factor that is coordinately regulated with cholera toxin. | 1986 | 2892514 | |
| antigenic recognition of pertussis and cholera toxin by the same antipeptide antibodies. | 1986 | 2892508 | |
| biochemical and cultural analysis of mycobacterial recombinants obtained by spheroplast fusion. | spheroplast fusion using polyethylene glycol 6000 resulted in mycobacterial recombinants with a frequency of about 10(-3). the parental strains were two carotenoid pigment mutants of mycobacterium aurum which were obtained by chemical mutagenesis of the wild-type strain with n-methyl-n'-nitro-n-nitrosoguanidine. isolation of recombinant clones was based on their pigmentation on löwenstein-jensen medium, and genetically stable recombinants were analysed for their carotenoid pigments and their alp ... | 1986 | 2892462 |
| mechanism of cell invasion by trypanosoma cruzi: importance of sialidase activity. | the sialidase activity of trypomastigotes of trypanosoma cruzi and its relationship to the ability of different stocks of the organism to infect cultured cells was examined. sialidase activity in lysates of trypomastigotes was confirmed and shown to be present in organisms of four different stocks of t. cruzi. in addition, sialidase activity was detected in sera of mice acutely infected with organisms of each of the stocks of t. cruzi examined. erythrocytes from these mice were agglutinated by p ... | 1987 | 2892363 |
| genetic study of piliation in escherichia coli: implications for understanding microbe-host interactions at the molecular level. | 1987 | 2892189 | |
| age-related changes of splenic t cells in mice--a flow cytometric analysis. | splenic t cells of c57bl/6 mice, ranging in age from newborn to 24 months old, were examined by two-colour flow cytometry using monoclonal antibodies (moabs) to thy-1, lyt-1, lyt-2 and l3t4. thy-1+ cells in the spleen increased gradually after the birth, and reached a plateau around at 3 months of age, but did not show a significant age-related decline even at 24 months of age. lyt subpopulations of t cells (lyt-1+2+, lyt-1+2-, lyt-1-2+) showed a proportional increase until 1 month of age, but t ... | 2009 | 2891881 |
| production and partial characterization of pili on non-o1 vibrio cholerae. | 1988 | 2891773 | |
| sewage pollution of bathing water. | 2010 | 2890829 |