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nature of "memory" in t-cell mediated antibacterial immunity: cellular parameters that distinguish between the active immune response and a state of "memory".immunizing infection in mice with listeria monocytogenes resulted in the generation of two distinct states of immunological reactivity. there was generated (i) a short-lived state of active immunity that functioned to urgently eliminate the infection organism from the tissues and (ii) a long-lives state of increased immunological potential that enabled the host to respond to seconday infection in an accelerated manner. short-lived active immunity was mediated by replicating t cells and expressed ...1975811559
nature of "memory" in t-cell-mediated antibacterial immunity: anamnestic production of mediator t cells.mice that survived an immunizing infection with listeria monocytogenes remained specifically resistant to lethal secondary infection for several months. this acquired, long-lived state of resistance was not dependent on activated macrophages that remained after the primary response. it depended, instead, on an acquired long-lived capacity on the part of immunized mice for generating mediator t cells faster and in larger numbers than normal mice. the number of mediator t cells generated in respon ...1975811558
new selective media of rivanol content for listeria monocytogenes cultures. 1975809949
further observations of changed growth of listeria monocytogenes on salt agar.the changes produced in listeria monocytogenes grown on salt media were studied. high concentration of nacl is really a possible inducer of filamentation as well as of spheroplasting in l. m. it acts by inhibiting the cell division of these bacteria.1975809946
[listeriosis during pregnancy and excretion of listeria by laboratory workers (author's transl)].the occurence of listeriosis during pregnancy in a medical technician and listeriosis in a neonate gave rise to an investigation of all laboratory workers being employed in this medical institute for the excretion of l.m. there had been no work with listeria or material containing listeria. in 11 out of 12 female employees, excretion of l.m. was observed over an extended period of time, also with a change of serotypes (see table 1 or fig. 1). it was supposed that frequent contact with laboratory ...1975809945
[listeria meningoencephalitis (3 cases)]. 1975809824
immunity to toxoplasma gondii induced in vitro in non-immune mouse macrophages with specifically immune lymphocytes.male and female cba mice were used to study in vitro the mechanisms involved in the development and expression of cellular immunity to toxoplasma infection. the lag phase preceding toxoplasma division was delayed in nonimmune macrophages obtained from peritoneal cavities stimulated with thioglycollate. specific anti-toxoplasma activity was conferred on nonimmune macrophages incubated with toxoplasma-immune spleen lymphocytes and soluble toxoplasma antigen. treatment of immune spleen cell populat ...1975809507
perinatal listeric septicemia in a celebese black ape.perinatal listeric septicemia was diagnosed in a still-born celebese black ape (macaca niger). the disease was characterized by prominent focal hepatic necrosis and a diffuse, acute, fibrinopurulent placentitis. small, gram-positive rods were demonstrable in sections of the placenta and in the liver and lungs of the fetus. listeria monocytogenes 1a was isolated from the liver of the fetus.1975809391
blastogenesis as an in vitro correlate of delayed hypersensitivity in guinea pigs infected with listeria monocytogenes.randomly bred guinea pigs of both sexes were injected intracardially with one-half a 50% lethal dose of listeria monocytogenes. when these animals were skin tested with 30 mug of a water-soluble extract of sonically disrupted listeria, animals had uniformly detectable levels of delayed-type hypersensitivity (dth) 6 days after infection. histological examination of skin test reaction sites, after fixation in helly fixative and giemsa staining, revealed a classical tuberculin-type infiltrate consi ...1975809361
effect macrophage activation on infection with treponema pallidum.infection of rabbits with treponema pallidum induces nonspecific acquired cellular resistance (acr) to listeria monocytogenes. this resistance can be adoptively transferred using thymus-dependent lymphocytes. since infections that induce acr are usually brought under control by cellular mechanisms, we sought to determine whether induction of acr in rabbits stimulates resistance to challenge with t. pallidum. when bcg-infected rabbits which suppressed the growth of listeria were challenged intrav ...1975809355
listeria as a cause of abortion and neonatal mortality in sheep. 1975809030
perinatal lamb mortality in western australia. 6. listeric infection.listeric abortion was diagnosed in sheep on 14 occasions between 1963-65, and 4 of these were associated with other major abortion pathogens. except for infection in one district, the outbreaks were scattered sporadically over the southern agricultural area. the diagnosis in 1963 was the first time listeriosis had been found in animals or man in western australia. l. monocytogenes was readily recovered in pure culture from all organs and sites cultured. all the strains were serotype 5 ivanov, wi ...1975809029
infections associated with ovine perinatal mortality in victoria.the occurrence of infections associated with perinatal mortality was investigated. in 1970, carcasses from 94 flocks distributed throughout victoria were examined by microbiological and histopathological techniques. carcasses from 4 of the same flocks were similarly examined in 1971. widespread occurrence of listeria monocytogenes and campylobacter fetus was demonstrated with l. monocytogenes being recognised in 25% of the flocks examined. no other bacterial pathogens commonly associated with ov ...1975809028
intermittent neutrophil-monocyte bactericidal defects in a patient with sarcoidosis.reccurrent abnormalities of polymorphonuclear leukocyte and monocyte bactericidal activity were demonstrated in a patient with sarcoidosis. defective function occurred during hypercalcemia complicating recovery from listeria meningitis, and during separate, unrelated episodes of erythema nodosum, staphylococcal cellulitis, and pneumococcal pneumonia. leukocyte morphology, oxidative metabolism, degranulation, and content of myeloperoxidase and lysozyme were normal, but low leukocyte alkaline phos ...1975808991
corynebacterium aquaticum septicemia. characterization of the microorganisms.an 85-year-old woman with the diagnosis of diabetic ketoacidosis developed septicemia during hospitalization. cultures of the patient's blood revealed the presence of gram-variable coccobacilli, later identified as corynebacterium aquaticum. the microorganisms grew aerobically on blood agar plates after incubation overnight. the colonies were convex, non-hemolytic and slightly yellow-pigmented. no growth was observed on macconkey and endo agar plates. the organisms were catalase-positive, oxidas ...1975808959
intracellular killing of listeria monocytogenes by activated macrophages (mackaness system) is due to antibiotic. 1975808734
[listeria excreters and their epidemiological significance (author's transl)].by using the best bacteriological methods of investigation and reading techniques we were able to discover 82 excreters from stool samples of 841 persons and to culture 113 listeria monocytogenes strains of different serotypes (1/2a, 4a, 4b, 4ab). following up several excreters over a longer time (1 1/2 years) revealed periods with positive and negative results. strains of listeria isolated from the stool samples of pregnant women have a particular significance and act as pointers to virulence. ...1975808708
listeria monocytogenes meningitis in a transplant recipient. 1975808652
cytotoxicity mediated by soluble macrophage product(s).the soluble macrophage product(s) released by nonimmune mouse peritoneal macrophages exposed to endotoxin or from listeria-immune macrophages after incubation with specific antigen mediated cytotoxic activity against malignant cell types and, to a lesser extent, against normal cells. only undiluted supernatants from nonimmune or listeria-immune macrophages cultured with medium 199 alone exerted some degree of cytotoxicity on the different target cell types tested. the macrophage product(s) retai ...1975808640
interrelations between mammals and pathogens of some bacterial diseases.various interrelations of mammals with some bacterial pathogens are analyzed. plaque and tularemia are the most thoroughly investigated infectious diseases in this respect. the importance of a different degree of susceptibility and sensitivity to infection for its development in mammalian reservoirs is underlined.1975808461
effect of corynebacterium parvum on the course of a listeria monocytogenes infection in normal and congenitally athymic (nude) mice.spleen counts of listeria monocytogenes in normal mice challenged with various numbers of organisms were generally lower in mice injected 3 days previously with killed corynebacterium parvum. this increased resistance was unexpected since c. parvum generally inhibits t cell-mediated immunity, the functional immunity against listeria being t cell-dependent. the inhibitory effect on t cells seemed to be compensated by the stimulatory effect of c. parvum on macrophages. therefore, the experiments w ...1975808049
[diagnosis of listeria monocytogenes by immunofluorescence].for precision of bacteriological diagnosis of listeria monocytogenes (l. m.) the immune fluorescent technique (ift) was assessed. on using the described immunization pattern high titres of specific antibodies were obtained from the immunized rabbits. the obtained hyperimmune sera yielded very good results when used in ift, and they were suitable for conjugate production. by means of ift l.m. was demonstrated from cultures, organ replicas and tissue sections of experimentally infected rabbits. th ...1975808008
listeria monocytogenes septicemia in pregnancy.a case of listeria monocyto-enes septicemia in a patient with a poor reproductive history is presented. the clinical aspects and implications of this infectious disease during pregnancy are discussed, and the role of listeria as a cause of recurrent pregnancy wastage is summarized.1975807894
listeria monocytogenes isolated from wapiti (cervus canadensis roosevelti).serotypes 1 and 4 listeria monocytogenes were isolated from 14 of 72 wapiti among four of five herds studied in northwestern california. more isolations of listeria were made during the summer months than during the other months of the study from one of the herds. the pathogenicity of the strains varied with their ability to ferment xylose and rhamnose.1975807750
specific detection and semiquantitation of micro-organisms in tissue by nucleic acidhybridization. i. characterization of the method and application to model systems.on the basis of circumstantial evidence, a number of human diseases have been postulated to result from the presence of occult infection. to investigate this problem amethod of specifically detecting and semiquantitaing trace quantities of bacterial dna in infected tissue has been devised. it is based on rna-dna hybridization using radiolabeled rnacomplementary to the dna of the organism being sought. the characteristics of the reaction are shown to conform to those expected for rna-dna hybri ...1975807659
activated macrophages in congenitally athymic "nude mice" and in lethally irradiate mice.resistance to the facultative intracellular bacteria, brucella abortus and listeria monocytogenes, is principally the result of acquisition of enhanced antibacterial activity by host macrophages, probably in response to lymphokines released by t lymphocytes. however, the present paper describes a surprisingly high resistance on the part of both congenitally athymic "nude" mice and of lethally irradiated mice compared with normal controls. this enhanced bactericidal activity was evident 24 hr aft ...1975807647
listeria monocytogenes infection in nude mice.as compared to phenotypically normal (nu/+)nmri mice showing the typical course of an experimental listeric infection, that of congenitally hypothymic (nude, nu/nu)nmri mice was found to be characterized from the outset bya chronic trend. during the early phase of the infection, significantly reduced numbers of listeria monocytogenes were observed in the spleens of nude mice.1975807526
phagocytosis and intracellular killing of staphylococcus aureus by normal mouse peritoneal macrophages.although staphylococcus aureus is incapable of intracellular multiplication in cultured mouse peritoneal macrophages, it is killed at a much slower rate than the avirulent staphylococcus epidermidis. in addition to the presence of capsular material which inhibits phagocytosis of specific strains of s. aureus, the data show that a number of cellular and environmental factors affect the functional capacities of mononuclear phagocytic cells. the data obtained by varying the initial level of infecti ...1975807524
incidence of listeria monocytogenes in nature.during a research project on the occurrence of listeria monocytogenes 194 strains were isolated in southern west germany during the years 1972 to 1974:154 from soil and plant samples (20.3%), 16 from feces of deer and stag (15.7%), 9 from old moldy fodder and wildlife feeding grounds (27.2%), and 8 from birds (17.3%). the highest number of isolates was obtained from uncultivated fields. the beta-hemolytic serovars 1/2b and 4b were were predominant; other serovars (some of them identified for the ...1975807164
[isolation of bacterial cultures from anabiosis]. 1975807022
letter: isolating listeria monocytogenes. 1975807018
rate of listeria monocytogenes shedding from frogs.leopard frogs (rana pipiens) were orally inoculated with listeria monocytogenes. most listeriae were shed 3-6 days after inoculation. the evidence indicated that the listeriae did not multiply in frogs and were unable to become established in the gastrointestinal tract.1975806711
killing in vitro of trypanosoma cruzi by macrophages from mice immunized with t. cruzi or bcg, and absence of cross-immunity on challege in vivo.peritoneal macrophages from t. cruzi-immune mice were resistant to infection in vitro with culture forms of the parasite. macrophage resistance appeared in infected mice about 21 days postinfection when parasitemia was still rising. resistance in vitro was nonspecific since macrophages from bcg-immune mice were resistant to t. cruzi, and since macrophages from t. cruzi-immune mice were resistant to infection in vitro with listeria were not resistant to challenge with t. cruzi even when the par ...1975806649
activation of mouse peritoneal cells to kill listeria monocytogenes by t-lymphocyte products.an in vitro system has been used to demonstrate that glass-adherent mouse peritoneal cells can be activated to kill intracellular listeria monocytogenes by antigen-stimulated t-lymphocytes derived from immunized mice. the soluble products of such stimulated lymphocyte cultures could only be shown to similarly activate peritoneal cells if the antigen used in both the immunization and lymphocyte stimulation was also present on the target intracellular organism.1975806534
effect of cell dose and dose of infectious agent on expression of protection against listeria monocytogenes and ectromelia virus in cell transfer models.two parameters (immune cell dose and dose of infectious agent) influencing the expression of protection by transferred immune spleen cells in listeria monocytogenes and ectromelia virus infection in mice were investigated. first, when recipient mice were infected with a constant dose of ectromelia virus, a linear relationship between log(10) cells transferred and the protection obtained expressed as log(10) decrease in virus plaque-forming units per spleen was obtained, as has been described pre ...1975806519
macrophage activation in mice lacking thymus-derived (t) cells. 1975806463
bacterial infections of the nervous system; etiologic and therapeutic aspects. 1975806402
portal hypertension following exchange blood transfusion with complications of listeria meningitis.a male infant, 17 months, developed portal hypertension after two exchange blood transfusions and a prolonged umbilical vein catheterization during the neonatal period. clinical course was characterized by an early onset of splenomegaly and after a latent period of time by a massive melena and hematemesis precipitated by listeria meningitis. treatment for portal hypertension consisted of splenectomy and proximal gastric devascularization. the importance of proper positioning of the catheter and ...1975806184
letter: isolating listeria monocytogenes. 1975806160
isolation of listeria monocytogenes type 04 from cases of keratoconjunctivitis in cattle and sheep.keratoconjunctivitis in cattle and sheep is usually recognized as a summer problem. the infective agency usually isolated from cattle is moraxella bovis. in sheep neisseria ovis and rickettsia (colesiota) conjunctivae are expected to be found. this report describes isolations of listeria monocytogenes from eye inflammations in housed cattle and sheep.1975806058
listeria monocytogenes. isolation from sheep and goats in northern norway. serogrouping and some biochemical reactions.listeriosis is a zoonosis of world-wide importance in many different animal species, especially cattle, sheep and goats. this report presents results of examinations of listeria monocytogenes strains from sheep and goats in northern norway.1975806057
[nature of bacteriocins].the bacteriocins comprise a large, heterogeneous group of bactericidal substances produced by bacteria from widely differing species. the best known bacteriocins are the colicins. some aspects of research on colicins are discussed especially their chemical nature and mode of action, and their genetic determinants.1975806026
resistance to infection with nocardia asteroides.mechanisms of host resistance to nocardia asteroides were studied in mice. two to six weeks after intraperitoneal or intravenous immunization with viable n. asteroides, mice were significantly resistant to intraperitoneal challenge with ld50-100 of n. asteroides in gastric mucin when compared with control (unimmunized) mice (p smaller than 0.03). resistance could not be transferred to normal mice with serum (1.5 ml administered intraperitoneally) or spleen cells (10-8 cells administered intraven ...1975805811
listeroisis in immunosuppressed patients. a cluster of eight cases.bactermia due to listeria monocytogenes developed in eight patients who were receiving immunosuppresive medications during a 15 month period at one hospital. seven survived. meningitis was documented in only the four who received kidney transplants. their neurologic signs were minimal, indicating a need to treat any immunosuppressed patient with listeria bacteremia for meningitis. during this period the incidence of listeria bactermia in immunosuppressed patients greatly exceeded that previously ...1975805536
nursing care study: an unusual cause of septicaemia in the neonate. 1975805420
[the rate of healthy carriers of listeria monocytogenes].the feces of 318 healthy adults were examined for l. monocytogenes by means of the cold enrichment and of two different selective media (nalidixic acid-trypaflavin-serum agar; braveny medium). 15 persons (4.7 percent) proved to be carriers. three of the 15 strains only caused hemolysis on sheep blood agar and belonged to serotypes 1/2b, 1/2c and 3c. the nonhemolytic strains without exception belonged to serotypes 4f and 4g. the braveny medium proved to be superior to the nalidixic acid-trypaflav ...1975805357
in-vitro effect of edta-tris-lysozyme solutions on selected pathogenic bacteria.the in-vitro effect of edta-tris-lysozyme solution on 16 pathogenic bacteria of medical or veterinary importance was determined. marked decreases in bacterial count occurred with pseudomonas aeruginosa, escherichia coli, moraxella osloensis and campylobacter fetus, and smaller decreses with salmonella typhimurium, shigella boydii, aeromonas hydrophila, proteus mirabilis, listeria monocytogenes and erysipelothrix insidiosa. the test solution had no effect on klebsiella ozaenae, brucella canis, co ...1975805241
the mediator of cellular immunity. ix. the relationship between cellular hypersensitivity and acquired cellular resistance in rats infected with listeria monocytogenes.acquired resistance to the intracellular bacterial parasite, listeria monocytogenes can be transferred to normal recipients by thoracic duct lymphocytes or peritoneal exudate cells obtained from rats infected with this organism; the appearance of protective cells in thoracic duct lymph coincides with the development in the donors of delayed-type hypersensitivity to listeria antigens and accumulation in induced peritoneal exudates of cells which are responsive to these antigens in the migration i ...1975805208
effect of nonspecific stimulation on the defense mechanisms of inbred mice.acquired resistance to facultative intracellular parasites was investigated in c57bl/6j inbred mice susceptibe to salmonella typhimurium but inherently resistant to listeria monocytogenes and in a/j inbred mice which showed the reverse relationship. a/j but not c57bl/6j mice were protected against s. typhimurium challenge by s. typhimurium phenol vaccine, s. typhimurium purified rna, or l. monocytogenes purified rna. c57bl/6j but not a/j could be protected against l. monocytogenes challenge by ...1975805175
listeria cell wall fraction: adjuvant activity in vivo and in vitro. 1975805002
new evidence for the non-infectivity of treponema pallidum for mice.we have recently shown that syphilitic rabbits are resistant to challenge with listeria monocytogenes. this resistance was thought to reflect stimulation of cell-mediated immunity by active infection with treponema pallidum. we now report data which show that the growth of listeria was not suppressed in mice inoculated with t. pallidum. re-inoculation with t, pallidum or with a large dose of an avirulent treponeme also failed to suppress the growth of listeria. these results contrast with those ...1975804955
serovariants of listeria monocytogenes and other listeria species. 1975804804
clinical listeriosis in renal allotransplantation.two cases of listeria monocytogens meningitis among 212 kideney transplanted patients (total of 339 patient years of observation) under immunosuppression with azathioprine and prednisone are presented. both cases developed shortly after an increase of the immunosuppression. the first case appeared in a 27-year-old man 5 days after a minor increase of the azathioprine dose from 75 to 100 mg/day. the course was relatively mild, and the patient was cured by tetracycline. the second case appeared in ...1975804802
transfer of nonspecific resistance to listeria monocytogenes using spleen cells from syphilitic rabbits (38574).the data presented show that spleen cells obtained from syphilitic rabbits can be used to transfer nonspecific resistance to listeria to normal recipients. this supports the hypotheisis that infection caused by t. pallidum induces a cell-mediated immune response.1975804700
antitumor activity of bacterial infection. i. effect of listeria monocytogenes on growth of a murine fibrosarcoma.growth of a murine fibrosarcoma was suppressed when tumor cells were mixed with viable listeria monocytogenes (lm) before intradermal injection into nonimmune syngeneic recepients. immunization of recipients, by intravenous injection of lm 11 days before transplantation of lm-tumor cell mixtures, eliminated the mortality associated with large doses of lm but did not alter the antitumor activity of the microorganisms. simultaneous injection of lm and tumor cells at separate sites failed to affect ...1975804566
cytokinetics and fate of sensitized lymphocytes. 1975804548
induction of acquired cellular resistance following transfer of thymus-dependent lymphocytes from syphilitic rabbits.syphilitic rabbits have previously been shown to resist challenge with listeria monocytogenes. thirty days after rabbits were infected with treponema pallidum, transfer of 4 to 6 times 10-8 viable spleen cells along with t. pallidum conferred resistance to listeria on normal recipients. treatment of the spleen cells with anti-thymus serum and complement inhibited or abolished their ability to transfer resistance to listeria. these results support the hypothesis that the ability of syphilitic rab ...1975804508
requirement for a bone marrow-derived component in the expression of cell-mediated antibacterial immunity.mice were x irradiated with 400 r and 1 week post-irradiation were found to be unable to develop antilisterial immunity after active or passive immunization with immunologically committed spleen lymphocytes from listeria-immune donors. this consequence of irradiation disappeared spontaneously within 21 days of exposure to x rays. mice irradiated with as much as 900 r could be passively protected by immunologically committed lymphoid cells from listeria-immune donors 10 days after irradiation if ...1975804449
susceptibility of thymectomized and irradiated mice to challenge with several organisms and the effect of dapsone on infection with mycobacterium leprae.b6c3f1 mice that had been thymectomized at 8 to 12 weeks of age, subjected to 950 r of whole-body x irradiation, and transfused with syngeneic bone marrow were challenged in a footpad with mycobacterium leprae or m. marinum, or intravenously or intraperitioneally with listeria monocytogenes. also, mice inoculated with m. leprae in a hind footpad were administered dapsone in the mouse chow. the thymectomized-irradiated (t + r) mice did not survive as well as non-thymectomized mice when housed in ...1975804443
editorial: delayed hypersensitivity and immunity in tuberculosis. 1975804285
bacterial endocarditis produced by listeria monocytogenes. case presentation and review of literature.a patient with endocarditis produced by listeria monocytogenes is presented, the twelfth such case reported. a review of the available literature shows that the infection has involved only the left side of the heart, has not been associated with debilitating diseases, and carries a significant mortality rate. otherwise, clinical and laboratory features have been the same as those of usual forms of bacterial endocarditis. it is pointed out that the listeria organism is commonly mistaken for erysi ...1975804251
[diagnostic value of agglutination reaction to listeria monocytogenes]. 1975804165
superoxide production by phagocytic leukocytes.mononuclear phagocytic leukocytes, as well as polymorphonuclear leukocytes, produce and release superoxide at rest, and this is stimulated by phagocytosis. of the mouse monocytic cells studied, alveolar macrophages released the largest amounts of superoxide during phagocytosis, followed by normal peritoneal macrophages. casein-elicited and "activated" macrophages released smaller quantities. in the guinea pig, polymorphonuclear leukocytes and casein-elicited macrophages were shown to release sup ...1975804030
the effect of leukocyte hydrolases on bacteria. iii. bacteriolysis induced by extracts of different leukocyte populations and the inhibition of lysis by macromolecular substances.the lysis of 14c-labeled bacteria by hydrolases of human and rabbit leukocytes was studied in vitro. while staphylococcus albus, streptococcus faecalis, and streptococcus mutans were highly susceptible to lysis, staphylococcus auresus was intermediate in its susecptibility to lysis by the leukocyte enzymes. group a streptococcus, listeria monocytogenes, shigella flexneri, escherichia coli, and mycobacterium smegmatis were very resistant to degradation by these enzymes. the lytic activity of leuk ...1975804017
delayed hypersensitivity and acquired cellular resistance in guinea pigs infected with listeria monocytogenes.randomly bred pigs of both sexes were injected intracardially with one-half of a 50% lethal dose of listeria monocytogenes. when infected animals were skin tested with 30 mug of a water-soluble extract of sonically disrupted listeria, both males and females had uniformly detectable levels of delayed hypersensitivity (dh) 4 days after infection. in males, cutaneous hypersensitivity to listeria antigens reached a peak on day 5 or 6 of infection, and high levels of dh persisted through the 7th week ...1975803918
letter: listeria meningitis during cefazolin therapy. 1975803807
listeriosis among willow grouse (lagopus lagopus) in captivity. 1975803676
listeria cell wall fraction: a b cell mitogen.a crude cell wall-rich fraction of listeria monocytogenes contains a substance or substances which cause blast transformation and thymidine incorporation by mouse spleen cells. the substance, listeria cell wall fraction (lcwf), is a b cell mitogen in the mouse. it is not endotoxin, in that it stimulates b cells in c3h/hej mice. it is weakly mitogenic for rat spleen cells and not at all mitogenic for human peripheral blood or tonsil lymphocytes. thus, it is dissimilar to both endotoxin and purifi ...1975803536
cell-mediated immune phenomena induced by lymphokines from splenic lymphocytes of mice with chronic staphylococcal infection.splenic lymphocytes from normal mice and from mice displaying delayed hypersensitivity to staphylococcus aureus were cultured in the presence or absence of specific staphylococcal antigens. the cell-free supernatant fluids from these lymphocyte cultures were assessed for their ability to alter the functional capacities of normal macrophages. it was found that supernatants from staphylococcus-immune cells cultured in vitro with antigen possessed migration inhibitory factor activity and also were ...1975803469
neonatal sepsis. a survey of eight year's experience at the louisville general hospital.information from 50 infants with neonatal septicemia from the louisville general hospital during an eight-year period (1964-1972) is presented. twenty-five infants had gram-positive and the other 25 had gram-negative organisms. e. coli (13 cases), staphylococcus (10 cases), and hemolytic streptococcus non-group a (7 cases) were the mustcommon causative microorganisms. only one of the 25 infants with gram-positive sepsis died; three with gram-negative sepsis died. listeria monocytogenes was demon ...1975803422
septicemia in renal transplant recipients.thirty-six renal transplant recipients with 47 episodes of septicemia were studied carefully at the bedside, in the laboratory, and, all too frequently, at autopsy. gram-negative bacilli were the pathogens most commonly responsible, folloed in order of frequency by gram-positive cocci, polymicrobic etiologic agents, listeria monocytogenes, and fungi. infections of the transplant site (urinary tract or transplant wounds) caused septicemia in 51% of the cases. other portals of entry included the l ...1976790736
listeria monocytogenes. macroabscesses of placenta.macroabscesses of placenta caused by listeria monocytogenes were observed in a 37-year-old febrile primigravida. she was prematurely delivered of a depressed 2310-g infant, who was resuscitated and promptly treated with antibiotics. mother and child are well at 10-year followup. although perinatal listeriosis with placentitis is not rare, its presentation as macroabscesses of the placenta has until now gone unreported in the english language literature.1979760011
[internuclear ophthalmoplegia in infectious encephalitis: observation on a case of listeriosis].an internuclear ophthalmoplegia was diagnosed and recorded electro-oculographically in a patient with pontomedullary listeriosis. the etiological differential diagnosis in case of internuclear ophthalmoplegia is discussed. it is emphasized that listeria monocytogenes encephalitis should be considered because this pathology may be electively located in the pontomedullary area and because of the encreasing frequency of human listeriosis.1978754276
listeria pneumonitis: induction of immunity after airborne infection with listeria monocytogenes.after implantation of approximately 10(3) listeria monocytogenes organisms into the lungs, mice develop an acute pneumonitis with dissemination of infection to a mediastinal lymph node (medln), liver, and spleen. the infections in a medln and spleen resolve in approximately 7 days, but the lung infection persists for a few days longer. pneumonitis is accompanied by a lymphoproliferative response in a medln and spleen, and immunity to listeria is conferred adoptively with medln and spleen cells b ...1978730382
[growth of some pathogenic microorganisms on chemically defined media which were proposed for sensitivity testing (author's transl)].the growth of 16 bacterial cultures, which belong to the frequently encountered pathogens, in three different chemically defined fluid media was investigated through turbidity measurements in comparison with mueller-hinton-broth. e. coli, salm. dublin, salm. typhi-murium, enterobacter cloacae, proteus mirabilis, pseud. aeruginosa and bac. cereus grew in two of the three tested defined media with approximately the same intensity as in the mueller-hinton broth. staph. aureus grew well only in one ...1978730218
[further observations on human infection by listeria monocytogenes].two cases of isolation of listeria monocytogenes type 1 from vaginal mucus of two pregnant women who underwent premature deliveries with death of foetuses are described.1978728263
listeria monocytogenes causing hospital-acquired enterocolitis and meningitis in newborn infants. 1978678926
neonatal listeria monocytogenes meningitis. a case report.the clinical presentation, bacteriological results, treatment, and outcome of listeria monocytogenes meningitis in a newborn infant are described. the neonatal listeriosis was of the late-onset variety, and the infant survived the infection, but hydrocephalus, which necessitated operative relief, developed. although 2 cases of listeria meningitis have previously been described in south africa, and opportunistic listeriosis is known to occur here, this is apparently the first documented case of n ...1978675389
suramin effects on macrophage phagolysosome formation and antimicrobial activity.the effects of suramin on phagolysosome formation and antimicrobial activity of mouse peritoneal macrophages cultivated in vitro have been studied. prolonged in vitro pretreatment of macrophages with high concentrations of suramin caused macrophages to form large fragile phagolysosomes in which the concentrations of the various lysosomal enzymes were inferred to be diminished. in addition, suramin-treated macrophages demonstrated enhanced exocytosis of acid phosphatase during phagocytosis of pol ...1978669808
changes in host resistance caused by nocardia brasiliensis in mice: cross-protection against listeria monocytogenes.listeria monocytogenes was used to study the rate of development, magnitude, and persistence of the antimicrobial resistance engendered by nocardia brasiliensis infection in mice. the growth of listeria in the liver and spleen was more effectively restricted in nocardia-infected mice than in noninfected animals. the development of delayed-type hypersensitivity to the nocardia antigen was closely correlated to the increased resistance to listeria, suggesting that both properties are the consequen ...1978640748
reversion of dextran sulfate-induced loss of antibacterial resistance by bordetella pertussis.parenteral injection of dextran sulfate 500 (ds 500; 50 mg/kg of body weight) into mice caused a complete loss of resistance to a sublethal (2 x 10(3) to 5 x 10(3)) infection with listeria monocytogenes. such loss could be prevented by pretreatment of animals with 3 x 10(9) heat-killed bordetella pertussis organisms (po) 5 to 30 days before the administration of ds 500. the increased phagocytic capcity induced by po was only exhausted when a fourfold dose of ds 500, effecting complete loss of an ...1978640739
[carrier state of listeria monocytogenes bacilli in pregnancy]. 1978640487
[listeria monocytogenes meningitis in the newborn and contamination in the maternity ward]. 1978637672
listeria monocytogenes infection with brain abscess formation--the first case in miyagi prefecture.a rare type of brain abscess formation caused by infection with listeria monocytogenes was observed in a 2-year-old boy. the patient did not respond to treatment with various antibiotics. the isolated organisms were found to be sero-type 4b. this is the first report of listeria monocytogenes infection in miyagi prefecture.1978635896
enumeration and ultrastructure of c4-producing free alveolar cells from guinea pig lung.free alveolar cells from guinea pig lung producing the fourth emoponent of c (c4) were identified, enumerated, and characterized by using anti-c4 fab-peroxidase conjugates in conjunction with transmission electron microscopy. the c4-producing cell population consisted of: 1) alveolar macrophages (am); 2) less well differentiated phagocytes similar in morphology to exudate macrophages; and 3) weakly phagocytic secretory cells with numerous profiles of rough-surfaced endoplasmic reticulum (er). in ...1978632583
prosthetic-valve endocarditis due to listeria monocytogenes.clinical and necropsy observations in the case of a patient with prosthetic-valve endocarditis due to listeria monocytogenes are presented. although rare cases of l. monocytogenes infection of natural cardiac valves have been reported, this represents the first known case of infection of a prosthetic cardiac valve by this organism.1978629227
chronic active hepatitis, haemolytic anaemia and listeria monocytogenes bacteraemia.the association of chronic active hepatitis with haemolytic anaemia is well known. both conditions may respond to steroid therapy which, in common with other causes of suppressed t-lymphocyte function, predispose to many types of infection. a case is described in which transient listeria monocytogenes bacteraemia occurred and the patient recovered without antimicrobial therapy.1978625461
bacterial endocarditis due to listeria monocytogenes in a pregnant diabetic.a case of bacterial endocarditis due to listeria monocytogenes in a pregnant, class d diabetic patient is presented. the importance of obtaining proper cultures and instituting appropriate antibiotic therapy promptly is emphasized. a favorable outcome was achieved in spite of the combined risk to the fetus of maternal diabetes and listeria endocarditis.1978618485
listeria monocytogenes endocarditis in hypertrophic cardiomyopathy. 1978565238
[different courses of listeria monocytogenes infection in canaries]. 1977557974
[cellular antibacterial immunity (author's transl)].facultatively intracellular bacteria (mycobacteria, brucellae, listeria monocytogenes, salmonella typhi etc.) may not necessarily be killed after having being phagocytosed by polymorphonuclear leucocytes or macrophages, cellular immunity having first to be built up. this results in the formation of specifically committed t-lymphocytes, which in turn release lymphokines after restimulation by homologous antigen. under the effect of lymphokines, mononuclear phagocytes are chemotactically attracted ...1979551085
anti-infective properties of vitamin a.1. six months after feeding a vitamin a free diet the liver content of mice was markedly reduced but not yet completely exhausted. these vitamin a deprived mice were either immunized with sheep erythrocytes or infected with listeria monocytogenes. in comparison to normal control mice no significant difference ws observed. this indicates that neither the immune system nor the mononuclear-phagocytic system was involved. 2. mice treated with a high dose of vitamin a showed increased antibody produc ...1979549269
[infectious listeria monocytogenes endocarditis. apropos of a case]. 1979543809
[bacterial meningitis in newborn infants. a retrospective study from a pediatric clinic 1967-1978].a total of 22 newborn infants (14 boys, 8 girls) have been admitted and treated for bacterial meningitis in the university pediatric service of geneva over a period of 11 years (may 1967 to may 1978). the three most common infectious agents were: group b beta-hemolytic streptococcus (6/22 cases), escherichia coli (6/22 cases), and listeria monocytogenes (4/22 cases). thirteen of the 22 infants died (a 59% mortality, in keeping with that observed in other centers). follow-up of the nine survivors ...1979541219
evaluation of gentamicin and penicillin as a synergistic combination in experimental murine listeriosis.the administration of a combination of penicillin and gentamicin to mice given an intraperitoneal challenge of a highly pathogenic strain of listeria monocytogenes resulted in increased survival as compared with groups receiving penicillin alone or gentamicin alone or a control group that received no antibiotic. the median survival of animals that eventually died was no longer than in groups receiving single antibiotics and suggests that additional studies should be carried out to further invest ...1979533266
mouse strain difference in the protection against listeria monocytogenes. 1979527919
simultaneous listeria monocytogenes septicaemia in mother and pre-term infant. 1979523369
infection of the brainstem by listeria monocytogenes.a case of brainstem infection by listeria monocytogenes is described. the patient was a 63 year old man previously in good health and his illness did not follow the usual bi-phasic pattern. there was no prodromal phase, and the progressive brainstem signs with a lymphocytosis and a normal sugar level in the csf led to a tentative diagnosis of viral brainstem encephalitis. ampicillin was begun only when signs of pulmonary infection developed. clinical diagnosis is difficult but ampicillin should ...1979512667
cns listeriosis: rhomboencephalitis in a healthy, immunocompetent person.a previously healthy woman had a febrile illness resembling aseptic meningoencephalitis. with the exception of mild increase in both csf pressure and protein concentration, initial findings were normal, including negative bacterial cultures. bilateral pyramidal and cerebellar signs with multiple lower cranial nerve pareses developed over a 48-hour period beginning on the tenth hospital day. repeated blood and csf studies had previously been nondiagnostic, but at that time, cultures became positi ...1979508167
mechanisms of listeria monocytogenes-mediated modulation of tumor growth.studies using listeria monocytogenes as an antitumor agent were initiated to determine the requirements for listeria-mediated tumor inhibition to occur. when strain 13 guinea pigs were injected with an admixture of viable listeria and a methylcholanthrene-induced fibrosarcoma in a ratio of 1 bacterium to 100 tumor cells, listeria had a marked capacity to inhibit tumor growth. this confirms an earlier study in our laboratory (m. m. dustoor, a. fulton, w. croft, and a. a. blazkovec, infect. immun. ...1979489127
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