Publications

localization and heterogeneity of central benzodiazepine receptors.		2010	2993939
syntheses and differentiating action of vitamin d endoperoxides. singlet oxygen adducts of vitamin d derivatives in human myeloid leukemia cells (hl-60).	singlet oxygen adducts of various vitamin d derivatives, 6,19-dihydro-6,19-epidioxyvitamin d (vitamin d endoperoxides, 2 and 2'), were chemically synthesized, and their biological activity in inducing differentiation of a human myeloid leukemia cell line (hl-60 cells) was examined. the potency of the endoperoxides derived from vitamin d derivatives possessing the 1 alpha-hydroxyl group such as 1 alpha, 25-dihydroxyvitamin d3 endoperoxides (2b and 2b') was markedly (10(-2)) diminished relative to ...	1985	2993611
ouabain-evoked norepinephrine release from intact rat sympathetic neurons: evidence for carrier-mediated release.	inhibition of the na,k-atpase is known to cause transmitter release from many neurons. the mechanism of [3h]norepinephrine release was examined in primary cultures of sympathetic neurons. ouabain caused [3h]norepinephrine release at concentrations that produced 80 to 90% inhibition of na,k-atpase activity. the effect of ouabain was compared with the effects of high k+ and the ca2+ ionophore a23187. [3h]norepinephrine release elicited by depolarization with high extracellular k+ was dependent on ...	1985	2993543
the structure of the double-stranded rna pentamer 5'(cacag) . 5'(cugug) determined by nuclear overhauser enhancement measurements: interproton distance determination and structure refinement on the basis of x-ray coordinates.	the structure in solution of the duplex rna pentamer 5'(cacag) . 5'(cugug), comprising the stem of the t psi c loop of yeast trnaphe, has been investigated by means of one- and two-dimensional nuclear overhauser enhancement measurements. all non-exchangeable base and sugar proton resonances with the exception of the h5'/h5" sugar resonances are assigned in a sequential manner. from the relative intensities of the cross-peaks obtained in the pure-phase absorption two-dimensional nuclear overhause ...	1985	2992954
the structure of the double-stranded rna pentamer 5'(cacag) . 5'(cugug) determined by nuclear overhauser enhancement measurements: interproton distance determination and structure refinement on the basis of x-ray coordinates.	the structure in solution of the duplex rna pentamer 5'(cacag) . 5'(cugug), comprising the stem of the t psi c loop of yeast trnaphe, has been investigated by means of one- and two-dimensional nuclear overhauser enhancement measurements. all non-exchangeable base and sugar proton resonances with the exception of the h5'/h5" sugar resonances are assigned in a sequential manner. from the relative intensities of the cross-peaks obtained in the pure-phase absorption two-dimensional nuclear overhause ...	1985	2992954
pheochromocytoma and asthma.		2010	2992890
rates of cholesterol synthesis and low-density lipoprotein uptake in the adrenal glands of the rat, hamster and rabbit in vivo.	the absolute rate of cholesterol acquisition from de novo synthesis and from receptor-dependent and receptor-independent low-density lipoprotein (ldl) uptake was determined in the adrenal glands of the rat, hamster and rabbit under in vivo conditions. the rate of incorporation of [3h]water into cholesterol in the adrenal gland was much higher in the hamster (1727 nmol/h per g) and rabbit (853 nmol/h per g) than in the rat (71 nmol/h per g). assuming that 23 atoms of 3h are incorporated into the ...	1985	2992599
macrophage colony-stimulating factor (m-csf) enhances the capacity of murine macrophages to secrete oxygen reduction products.	the capacity of macrophage colony-stimulating factor (m-csf) to enhance respiratory burst activity in peritoneal macrophages was measured. macrophages incubated for 48 hr or more with concentrated l cell-conditioned medium as a source of m-csf released two to three times as much o2- in response to pma as did unexposed macrophages. stimulation was noted at concentrations of colony-stimulating activity from 0.1 to 2000 u/ml and was maximal at 10 to 100 u/ml. purified, endotoxin-free csf enhanced s ...	2010	2991376
receptor (norepinephrine), p-site (2',5'-dideoxyadenosine), and calcium-mediated inhibition of prostaglandin and forskolin-activated cyclic amp-generating systems in human platelets.	prostaglandin d2, 2-chloroadenosine, forskolin and combinations of these agents increase cyclic amp-levels in intact human platelets. the inhibition of activated cyclic amp-generating systems by 1) alpha2-adrenergic receptor-mediated hormonal input (norepinephrine), 2) a p-site agent (2',5'-dideoxyadenosine) and 3) a divalent cation (calcium) were examined: 1) norepinephrine produces non-competitive inhibition of both forskolin and prostaglandin d2(pgd2)-stimulated cyclic amp-accumulation in int ...	1985	2991349
mapping of a gene that regulates hemolysin production in vibrio cholerae.	a gene that regulates the hemolysin structural gene (hly) was found to be tightly linked to the tox-1000 locus of vibrio cholerae rj1 and separated from hly by a large section of the v. cholerae genetic map. this hemolysin regulatory gene was designated hlyr.	1985	2991206
genetic analysis of the cholera toxin-positive regulatory gene toxr.	southern blot analysis with a toxr-specific gene probe indicates that vibrio cholerae 569b has a 1.2-kilobase deletion near the toxr gene. heterologous conjugative crosses were carried out between the ei tor strain rv79 and 569b tox mutants. tox+ recombinants showed the same linkage properties to the his locus as to the previously mapped tox locus of 569b. southern blot analysis with the toxr probe of the tox+ recombinants obtained in these heterologous crosses showed that these recombinants had ...	1985	2991197
characteristics of hypertensive patients with increased plasma na+-k+ pump inhibitory activity.	recent studies in our laboratories and in the laboratories of other investigators suggest the presence of a sodium-potassium pump inhibitor in the plasma of some patients with arterial hypertension. we here review these studies in an attempt to determine what characteristics increase the likelihood of detecting the inhibitor. the review suggests but does not prove that the inhibitor is most likely to be found in males with increased sodium intake, decreased renal function, and decreased plasma r ...	2010	2990770
metastasis of an occult gastric carcinoma suggesting growth of a prolactinoma during bromocriptine therapy: a case report with a review of the literature.	the treatment of a slowly growing invasive prolactinoma with bromocriptine for 8 months resulted in a substantial decrease in plasma prolactin levels despite rapid suprasellar tumor expansion. on exploration, this uncommon observation could be attributed to hematogenous metastasis from an occult gastric adenocarcinoma to the pituitary tumor. apart from infiltration of neighboring parts of the hypothalamus, autopsy revealed no other hematogenous metastases. this extraordinary type of neoplasm-to- ...	2010	2989726
conditioned taste aversion suppresses induction of delayed-type hypersensitivity immune reactions.	conditioned taste aversion was induced in mice by pairing saccharin drinking with an intraperitoneal injection of lithium chloride, a toxic but nonimmunosuppressive drug. conditioned mice showed not only suppressed saccharin drinking but also a 75% reduction in the induction of delayed-type hypersensitivity immune responses to low doses of sheep erythrocytes. this effect was observed with doses of lithium chloride which had no effect of their own on immune functions. in addition, a reduction in ...	1985	2987987
organization, structure and expression of murine interferon alpha genes.	using a human interferon-alpha probe we have isolated recombinant phages containing murine interferon-alpha (mu ifn-alpha) genes from a genomic library. one of these phages contained two complete mu ifn-alpha genes and part of a third gene. the insert of a second phage held two ifn genes. this indicates that the mu ifn-alpha genes are clustered in the genome as is the case for the analogous human genes. the nucleotide sequences of these 5 genes were determined. they show that the genes are all d ...	1985	2987810
electron microscopy after direct ultracentrifugation.	a direct ultracentrifugation technique was used in the preparation of skin lesion specimens for examination by electron microscopy. the concentration factor of centrifuged specimens was estimated to be in excess of 1,000-fold compared to conventional adsorption techniques. this resulted in an increase of over 300% in the detection rate of herpesviruses and poxviruses from skin lesion specimens.	2010	2987776
enterotoxin-induced fluid accumulation during experimental salmonellosis and cholera: involvement of prostaglandin synthesis by intestinal cells.	challenge of rabbit intestinal loops with salmonella typhimurium or vibrio cholerae resulted in significant elevation of mucosal cyclic adenosine monophosphate (camp) and prostaglandin concentrations. this effect could be reproduced in vitro by exposing either isolated epithelial cells from normal rabbits or chinese hamster ovary cells to purified cholera toxin or cell-free lysates of salmonella. indomethacin treatment of animals challenged with salmonella resulted in less fluid accumulation, in ...	1985	2986318
a new beta-lactamase plasmid in neisseria gonorrhoeae.		1985	2984155
cloning of extracellular dnase and construction of a dnase-negative strain of vibrio cholerae.	the structural gene xds for extracellular dnase of vibrio cholerae was cloned and inactivated by insertion of the transposon tn5. the inactivated gene was introduced into the chromosome of v. cholerae by recombination to construct an extracellular dnase-negative strain. tn5-mediated transposon-facilitated recombination was used to establish the position of xds between the pro-1 and ile-201 markers on the genetic map of v. cholerae. the extracellular dnase-negative strain described here should be ...	1985	2982738
human endothelial cells modulate granulocyte adherence and chemotaxis.	although human endothelial cells (ec) and granulocytes interact in several ways, the factors that regulate such interactions are not well defined. in this study we found that ec and their products directly altered granulocyte adherence (ga) and chemotactic activity. the spontaneous adherence of granulocytes to human umbilical vein ec monolayers was significantly reduced at 5, 15 and 30 min if the granulocytes were preincubated with ec that were stimulated by rocking. at 30 min the spontaneous ad ...	1985	2981924
characterization of an rna polymerase activity from hela cell mitochondria, which initiates transcription at the heavy strand rrna promoter and the light strand promoter in human mitochondrial dna.	an rna polymerase activity capable of initiating transcription at both the heavy strand rrna promoter and the light strand promoter of human mitochondrial dna has been partially purified from hela cell mitochondria and characterized in its requirements and products. the ratio of the two transcription initiating activities varied considerably from preparation to preparation. the human mtrna polymerase partially purified by deae-cellulose and heparin-agarose chromatography exhibits a great sensiti ...	1985	2981880
autoregulation of the bacteriophage p22 scaffolding protein gene.	during the formation of each bacteriophage p22 head, about 250 molecules of the product of gene 8, scaffolding protein, coassemble with and dictate correct assembly of the coat protein into a proper shell structure. at approximately the time that dna is inserted inside the coat protein shell, all of the scaffolding protein molecules leave the structure. they remain active and participate in several subsequent rounds of shell assembly. previous work has shown that scaffolding protein gene express ...	1985	2981337
middle tumor antigen of polyomavirus transformation-defective mutant ng59 is associated with pp60c-src.	we have found that lysis of mouse embryo cells infected with the polyomavirus host range transformation-defective (hr-t) mutant ng59 under gentle conditions that avoid ionic detergents results in detectable ng59-encoded middle tumor antigen (mtag) associated with pp60c-src. this mtag-pp60c-src complex could be immunoprecipitated from ng59-infected cell lysates by either sera from animals bearing polyomavirus-induced tumors or by monoclonal antibodies directed against mtag. immune complex kinase ...	1985	2981329
differential stability of host mrnas in friend erythroleukemia cells infected with herpes simplex virus type 1.	the consequences of herpes simplex virus type 1 infection on cellular macromolecules were investigated in friend erythroleukemia cells. the patterns of protein synthesis, examined by polyacrylamide gel electrophoresis, demonstrated that by 4 h postinfection the synthesis of many host proteins, with the exception of histones, was inhibited. examination of the steady-state level of histone h3 mrna by molecular hybridization of total rna to a cloned mouse histone h3 complementary dna probe demonstr ...	1985	2981326
herpes simplex virus and cytomegalovirus infections in burned patients.	herpesvirus infections are commonly seen in immunosuppressed patients and may account for considerable morbidity and some mortality. we prospectively studied 52 patients with severe burn injuries in order to determine the prevalence of viral infections in this group of patients. serologic testing was done each week to diagnose primary and reactivation infections. twenty-seven of 52 patients (52%) became infected with either herpes simplex virus (hsv) or cytomegalovirus (cmv) or both. hsv infecti ...	1985	2981325
the modification of the oxidative metabolism of cells derived both locally and at distance from the site of an acute inflammatory reaction.	during an acute nonspecific inflammatory reaction initiated in the pleural cavity by a nondiffusible stimulus (calcium pyrophosphate crystals), the oxidative metabolism, as measured by chemiluminescence and superoxide release, of cells harvested from both the inflammatory site and at points distant from it was studied. the oxidative metabolism of peritoneal macrophages, obtained from rats undergoing an inflammatory reaction (pleurisy), demonstrated a transient decrease in activity compared with ...	1985	2981279
inhibition of cytotoxic t lymphocyte-mediated lysis by etya: effect independent of arachidonic acid metabolism.	cytotoxic t lymphocyte (ctl)-mediated lysis of target cells was inhibited by 5,8,11,14-eicosatetraynoic acid (etya) and other inhibitors of the lipoxygenase pathway at concentrations that inhibited arachidonic acid metabolism in mixed lymphocyte cultures. inhibition was reversible and selective for the "lethal hit" stage in the ctl-target interaction. studies to define ctl-specific arachidonic acid metabolites demonstrated that cloned ctl populations have little or no capacity to metabolize arac ...	2010	2981259
cloning of the gene for the common pathogenic neisseria h.8 antigen from neisseria gonorrhoeae.	neisseria gonorrhoeae dna that encodes the pathogenic neisseria h.8 common antigen was cloned in the lambda phage sep6. the recombinant phage, designated s6h.8, was detected immunologically with a monoclonal antibody that binds to the h.8 antigen. the gonococcal and s6h.8 forms of the antigen yielded identical partial proteolysis epitope maps. neisseria species that did not manifest the h.8 antigen showed little or no dna homology with s6h.8. this clone should facilitate investigation into the c ...	1985	2981198
murine natural resistance to trypanosoma lewisi involves complement component c3 and radiation-resistant, silica dust-sensitive effector cells.	the phenomenon of natural (innate) resistance is exemplified by the solid resistance of mice to infection with the rat-specific trypanosoma lewisi. we provide more information about the mechanism of resistance in this model system. resistance was not diminished in aged mice or reduced by ionizing radiation or splenectomy. there was no difference in resistance of c5-deficient mice (b10.d2/osn and akr) compared with their normocomplementemic counterparts (b10.d2/nsn and c57bl/6). treatment of mice ...	1985	2981195
sclerosing hemangioma of the lung. immunohistochemical characterization of its origin as related to surfactant apoprotein.	lung tissues from 13 patients with pulmonary sclerosing hemangioma were studied with antibody against surfactant apoprotein, factor viii-related antigen, or lysozyme. surfactant apoprotein was detected in the cytoplasm of the cells lining cystic spaces and papillary projections. surfactant apoprotein was found in a small number of stromal cells with abundant eosinophilic or clear cytoplasm and round to oval nuclei, which were characteristic in pulmonary sclerosing hemangioma as the main componen ...	2010	2981138
plasma atrial natriuretic peptide concentrations during induction of anesthesia and acute volume loading in patients undergoing cardiac surgery.	induction of anesthesia with fentanyl for coronary artery bypass grafting decreased (p less than .05) plasma atrial natriuretic peptide (anp) concentrations from awake values in twelve patients. during a steady state of anesthesia before surgery, isotonic saline solution (10 ml/kg) was infused simultaneously with the elevation of the lower extremities in six patients, while six subjects served as controls receiving no volume loading and having no leg raising. the anp levels returned to the awake ...	2010	2980951
choledochal cysts in the adult.	although choledochal cyst is generally considered a disorder of childhood, in approximately 20% of patients a cyst is first recognized in adult life. we reviewed nine adults who underwent operation for choledochal cyst from 1974-1985 at yale new haven hospital. presenting symptoms included: crampy right upper quadrant pain, jaundice, pruritus, cholangitis, pancreatitis, hepatomegaly, and elevated liver function tests. seven patients had undergone previous biliary surgery. the eight patients with ...	2008	2980768
comparative investigation of human endomyocardial biopsy.		1986	2979163
oral manifestations of beckwith-wiedemann syndrome.	a report of case of a patient with beckwith-wiedemann syndrome is presented. the macroglossia associated with the syndrome necessitated long-term dental follow-up to prevent and treat problems with occlusion, speech, and esthetic appearance that might develop. early intervention might be required if feeding or respiratory difficulties, resulting from the macroglossia, arise. the diagnosis of the syndrome should alert the dentist to the increased incidence of intra-abdominal malignancies and the ...	2010	2978762
oral manifestations of beckwith-wiedemann syndrome.	a report of case of a patient with beckwith-wiedemann syndrome is presented. the macroglossia associated with the syndrome necessitated long-term dental follow-up to prevent and treat problems with occlusion, speech, and esthetic appearance that might develop. early intervention might be required if feeding or respiratory difficulties, resulting from the macroglossia, arise. the diagnosis of the syndrome should alert the dentist to the increased incidence of intra-abdominal malignancies and the ...	2010	2978762
[plasma level of atrial natriuretic peptide in patients with uncomplicated essential hypertension].		2010	2978726
tissue-derived biomaterials and their use in cardiovascular prosthetic devices.	a variety of tissues and tissue components, ranging from allograft and xenograft tissues to albumin- and collagen-coated synthetic materials, have been used to fabricate cardiovascular prosthetic devices. tissue-derived biomaterials include both viable and non-viable tissues as well as individual tissue components which have undergone some degree of preimplantation processing. a review of the biochemistry, immunogenicity, mechanical properties, physicochemical properties, preimplantation process ...	2010	2978589
cell surface heparan sulphate implicated in haemopoietic growth factor signalling.		2010	2978375
aids: clinic v and the role of gdps.		2010	2978300
[long-term follow-up on change of antithyroid antibody in chronic lymphocytic thyroiditis].		2010	2978256
[cyclosporin a inhibits arachidonic acid metabolism in cultured cells].		1988	2978254
[transcranial pulsed doppler in the diagnosis of cerebrovascular pathology: methodology, indications and limitations].	doppler analysis of flow in intracranial arteries is now possible using a 2 mhz probe, allowing sufficient penetration of bone to obtain signals noninvasively and to measure rate of flow in middle (mca), anterior (aca) and posterior (pca) cerebral arteries and in basilar trunk. practical applications of this new method are numerous in cerebrovascular disease and, despite certain limitations due to anatomic factors, transcranial doppler may identify stenosis of the intracranial arteries and study ...	2010	2977876
changes in colour temperature characteristic of cholesteric temperature indicators provoked by uv radiation.		2009	2977692
expression of the escherichia coli lamb gene in vibrio cholerae.	a phage lambda mediated transduction system was devised to facilitate molecular analysis of vibrio cholerae. a lamb expression plasmid, pamh62 was introduced into vibrio cholerae by conjugation. the resulting v. cholerae derivatives harboring pamh62 produced substantial amounts of the lamb protein. this protein was properly inserted into the outer membrane, as suggested by (i) its localization into the cell envelope, (ii) its association with the peptidoglycan layer of the cell wall, and (iii) i ...	1986	2977630
[myosin isoforms of the developing skeletal muscles in the loach].	changes in the myosin isozyme spectrum were studied in the loach developing skeletal muscle. it was shown using disk-electrophoresis in polyacrylamide gel and peptide mapping that light and heavy myosin chains from the larval muscles, as well as from the red and white muscle of adult fish differ from each other. forms of myosin light and heavy chains were found which were characteristic of the larval muscle only.	2009	2976485
[myosin isoforms of the developing skeletal muscles in the loach].	changes in the myosin isozyme spectrum were studied in the loach developing skeletal muscle. it was shown using disk-electrophoresis in polyacrylamide gel and peptide mapping that light and heavy myosin chains from the larval muscles, as well as from the red and white muscle of adult fish differ from each other. forms of myosin light and heavy chains were found which were characteristic of the larval muscle only.	2009	2976485
regulation of ca2+-pump from cardiac sarcoplasmic reticulum.		2010	2976454
the relationships between oligomeric structure and function of band 3 protein from human erythrocyte membranes: present knowledge and suggestions for further experiments.		1988	2976450
[treatment of chronic cardiac decompensation in patients 70 years of age and older].		2010	2976342
ex vivo platelet studies following oral nisoldipine in normotensive insulin-dependent diabetics and non-diabetic controls.	the effect of 24 hours and 7 days treatment with nisoldipine (10 mg, twice daily) on platelet function was studied in 12 normotensive volunteers of whom six were insulin-dependent diabetics without clinical evidence of vascular complications. platelet aggregation was assessed by platelet rich plasma (prp) and whole blood (wb) techniques. in addition, the effect of nisoldipine on platelet hyperaggregability following exercise was assessed. after taking nisoldipine for 24 hours, in vitro platelet ...	2010	2976336
hyperresponsiveness to water immersion in sodium retaining cirrhotics: the role of atrial natriuretic factor.	cirrhotics do not respond uniformly to head-out water immersion (hwi). some cirrhotics have an exaggerated natriuresis while others are unresponsive. we studied the humoral and urinary responses to hwi in 5 cirrhotics and compared this to 5 normals on the same 20 mm sodium intake. these cirrhotics had a documented tendency to salt and water retention but had minimal or no evidence of significant ascites. plasma levels of atrial natriuretic factor (anf) increased during immersion in both groups. ...	2010	2976331
[biosynthesis of prostaglandin endoperoxide intermediates and its application].		2010	2976314
pharmacological and behavioral effects of d1 dopamine antagonists.	this work includes the effects of sch 23390 and related benzazepines on behavior and attempts to relate these effects to their d1 dopamine antagonist action. effects on conditioned avoidance responding (car) in rats were studied under the same conditions in which in vivo binding of the radioiodinated d1 specific benzazepine 125i-sch 38840 was measured. it was found that there is very close agreement between the time-course for antagonism of car and for in vivo displacement of 125i-sch 38840 from ...	1988	2976247
[mechanisms of cutaneous accidents related to non-steroidal anti-inflammatory agents].		2010	2976215
effects of ethanol withdrawal on beta-endorphin levels in rat brain and pituitary.	rats which received a liquid diet containing 6.5% (w/v) ethanol for three weeks became tolerant to the hypothermic effect of an acute dose of ethanol. withdrawal of this diet was followed by loss of the tolerance within 3 days, and by an accompanying pattern of changes in levels of immunoreactive-ir-beta-endorphin in several brain regions. an initial decrease in levels on days 1 and 3 of withdrawal was followed by recovery to control levels on days 8 and 15. this pattern was found in the arcuate ...	1988	2976169
acute intervention in myocardial infarction--role of thrombolytic therapy and adjuvant angioplasty.		2010	2976079
a device for microcomputer controlled stimulation of cardiac muscle.	an interface is described which substitutes a stimulator for analysis of contractile properties of a muscle. a solution is presented for use of a computer both for analysis and stimulation control. a programme for such a purpose is described.	2010	2975802
[application of ptca steerable guide wire for abdominal and peripheral interventional angiography].		2010	2975374
[contamination of cheese with listeria monocytogenes].		1988	2975368
translational signals of a major head protein gene of bacteriophage lambda.	the d gene of bacteriophage lambda which codes for a major head protein is expressed at a high level during lytic growth. we have constructed a set of d-lacz gene fusions in order to examine the factors determining the high efficiency of the d translational initiation signals. it was found that an integral sequence, 300 bp long and upstream of the atg initiation codon, is required for maximal protein synthesis.	1988	2975351
sequentially alternating hormone chemotherapy with high-dose medroxy-progesterone acetate and low-dose epirubicin for the treatment of hormone-resistant metastatic prostatic cancer.	thirty patients with hormone-resistant metastatic progressive prostatic carcinoma were treated with sequentially alternating hormone chemotherapy. they were given 1,000 mg medroxyprogesterone acetate (mpa) orally for 26 days followed by intravenous doses of 25 mg/m2 epirubicin weekly for 4 weeks. the median duration of the treatment was 29 weeks (range 8-84). in 2 patients a more than 50% reduction in the size of measurable lymph node metastases was observed and in 2 others skeletal metastases d ...	2010	2975221
atrial natriuretic factor alters autonomic interactions in the control of heart rate in conscious rats.	regulation of heart rate was studied in rats receiving either i.v. saline at 64 microl/min or synthetic 28-residue rat atrial natriuretic peptide (anf) at a dose sufficient to decrease mean arterial blood pressure by 10%. autonomic influences were deduced from steady-state heart rate responses of each group to propranolol, atropine, or propranolol and atropine combined. a multiplicative model of heart rate control was used to derive quantitatively from the data the modulation of intrinsic heart ...	1988	2975192
[systematic approach to the study of the health of schoolchildren].		2010	2975053
difference in second-formant transitions between aspirated and unaspirated stop consonants preceding [a].		2010	2974912
the ultrastructure and atpase nature of polar membrane in campylobacter jejuni.	polar membrane in campylobacter jejuni has been visualized on membrane vesicles. it was composed of doughnut-shaped particles 5-6 nm in diameter, with stalks, arranged in a hexagonal array. this structure was stabilized on the membrane by a high ionic strength buffer in the presence of 2-mercaptoethanol. histochemical staining indicated localized atpase activity at the poles of the cells. an atpase with distinctive properties has been isolated and purified from this organism; it gives a specific ...	1988	2974756
[cerebral edema with hyperammonemia in valpromide poisoning. manifestation in an adult, of a partial deficit in type i carbamylphosphate synthetase].	a case of cerebral oedema developed during an apparently common attempted suicide with valpromide is reported. the most conspicuous biochemical abnormality was hyperammonaemia. the oedema proved refractory to the standard medical treatment of intracranial hypertension, and decompressive craniectomy was performed with only minor sequelae. the cerebral oedema cum hyperammonaemia syndrome led to the discovery, in this hitherto asymptomatic adult subject, of a 50 per cent deficiency in type a carbam ...	2010	2974563
use of decision analysis in a complicated case of renovascular hypertension.		2010	2974442
activation of a cytosolic serine protein kinase by epidermal growth factor.	exposure of a-431 cells to epidermal growth factor (egf) results in a rapid enhancement (approximately 10-fold) of cytosolic serine protein kinase activity. the increase in serine kinase activity may be detected using a number of peptide and protein substrates. enhancement of kinase activity occurs within 1 min of exposure of the cells to egf and reaches a maximum in 5 min. similar results were obtained with a variety of cell lines. we have partially purified the egf-activated kinase from a-431 ...	2010	2974035
[preparation of 125i-labelled monoclonal antibodies of the insulin receptor].	three monoclonal anti-insulin receptor antibodies have been labelled with 125i according to various methods (cloramine t, lactoperoxidase and iodo-gen). the effect of labelling on antibody structure and function has been characterized using the following parameters: a) specific activity obtained in four different labelling procedures, at least; b) tca labelled antibody precipitable 90 days after labelling; c) interaction between labelled antibodies and the insulin receptor; d) ability of antibod ...	2010	2973824
assessment of the effectiveness of glove use as a barrier technique in the dental operatory.	to assess the effectiveness of routine glove use as a barrier technique in the dental operatory, the relationship between frequency of glove use and hepatitis b infection was examined. hepatitis b screening results and information on infection control practices of 1,109 dentists who attended the 1985 annual session were compiled and statistically analyzed. the results showed that 18% of the dentists wore gloves routinely, 65% wore gloves intermittently, and 17% never wore gloves. frequency of gl ...	2003	2972765
iron-regulated hemolysin production and utilization of heme and hemoglobin by vibrio cholerae.	el tor and non-o1 strains of vibrio cholerae were analyzed to determine whether synthesis of secreted hemolysin was influenced by the concentration of iron in the medium. synthesis of hemolysin was found to be iron regulated in both el tor and non-o1 isolates. increased levels of hemolytic activity were detected in supernatants of iron-starved cells. spontaneous hemolysin-deficient mutants of one non-o1 strain were found to occur at high frequency. these variants also failed to synthesize vibrio ...	1988	2971620
plasma concentrations of c4b-binding protein and vitamin k-dependent protein s in term and preterm infants: low levels of protein s-c4b-binding protein complexes.	we have determined the plasma concentrations of protein s and c4bp in 25 term and 26 preterm infants by radioimmunoassay. both the total concentration and the concentration of free protein s were quantified. the concentration of c4bp was very low in preterm infants (mean 6% of the adult level). in term infants, the level had increased to a mean of 18%. total protein s was decreased both in preterm and term infants, 4.0 mg/l and 6.8 mg/l respectively, as compared to the mean adult concentration, ...	2010	2967718
the effect of an acute maternal stress on beta-endorphin and growth hormone releasing factor in the rat fetus.	pregnant rats were injected with saline or l-tyrosine methylester hcl (200 mg/kg) and subjected to an acute forced immobilization stress on day 20 of gestation. at 10, 30, 60, and 120 minutes after the onset of stress, their fetuses were dissected out, and the contents of hypothalamic and pituitary immunoreactive beta-endorphin (ir-beta-ep) and hypothalamic immunoreactive growth hormone-releasing factor (ir-grf) were determined by specific radioimmunoassays. the maternal stress arose a significa ...	1988	2967192
[193 cases of gastroschisis and omphalocele--postoperative results].	treatment was applied to 97 cases of omphalocele and 96 cases of gastroschisis at the dortmund department of paediatric surgery over the past 20 years. the survival rate was 122. follow-up checks were recently applied to 56 of those former patients, after nearly ten years had elapsed from surgery. thirty-eight of these patients were clinically examined, while questionnaires were completed for the rest. primary closures had been performed on 50 per cent of the cases, while the defects in the othe ...	2010	2966527
t lymphocyte infiltrates in inflammatory synovia are oligoclonal.		2010	2966470
[genetic epidemiology of huntington chorea in chile].		1987	2966430
hmos and the quality of care.	various studies of selected health maintenance organizations (hmos) suggest that the quality of their medical care is comparable to that delivered in the fee-for-service (ffs) sector. unfortunately, these studies are based on a small number of mature hmos that were operating in an environment less focused on competition and cost containment than is the case today. it is the thesis of this paper that the current environment increases the importance of quality assessment and assurance for both hmo ...	2010	2966120
[study of lymphocyte subpopulations in alcoholic liver cirrhosis].		2010	2965321
aseptic necrosis of bone in icr mice.	aseptic bone necrosis was observed in the tibia of 23 icr mice. histological changes were characterized by a loss of marrow tissue with proliferation of connective tissue and bone necrosis with empty osteocytic lacunae. focal necrosis was confined beneath the articular cartilage. extensive necrosis was present in half or all of the epiphysis. massive necrosis was noted in the diaphysis of one animal. it was considered that focal necrosis might be related to degenerative osteoarthritis, and that ...	2010	2965280
atrial natriuretic peptide levels during angiotensin infusion and indomethacin administration are consistent with angiotensin-mediated regulation in man.	low-dose angiotensin ii (ang ii) infusion raised plasma atrial natriuretic peptide (anp) levels only when endogenous renin-angiotensin levels were low, as in aldosterone-producing adenoma. when plasma renin activity (pra) levels rose tenfold following removal of the tumour, low-dose ang ii infusion no longer stimulated anp, but fivefold higher doses did. indomethacin lowered both pra and anp in bartter's syndrome and in normal subjects. the effect of indomethacin on anp is probably not direct, s ...	1987	2965235
evidence for in vitro regulation of ige receptors on the human basophil membrane by their removal and reexpression: effects of ca2+, mg2+, some metabolic inhibitors and fetal calf serum.	human basophils free of receptor-bound ige and suspended in rpmi-1640 + 0.2% edta or in a buffered salt solution lacking ca2+ and mg2+ bound optimal quantities of 125i ige. in media containing ca2+ and mg2+ such as rpmi-1640 alone or a buffered physiologic salt solution binding was reduced significantly in the first 60 min and remained essentially unchanged in the next 120 min. scatchard analysis showed the reduction to be due both to loss of number and affinity of receptors. the presence of bot ...	1988	2965111
[endogenous opioid system in the realization of the analgesic effect of alpha-tocopherol in reference to algomenorrhea].	beta-endorphin-like immunoreactivity was studied in 7 patients with algomenorrhea during pain attack and 15 minutes after alpha-tocopherol administration with a therapeutic aim (till the analgetic effect was reached). there was an increase in beta-endorphin-like immunoreactivity after alpha-tocopherol administration. naloxone administration to 9 patients with algomenorrhea of various etiology resumed the pain. the effect of alpha-tocopherol application for pain relief depended on the pathogenesi ...	2010	2964879
[therapeutic modes in obstructions due to colon cancer].		2010	2964681
gender differences in variables associated with psychosocial adjustment to a burn injury.	the purpose of this study was to determine whether variables associated with psychosocial adjustment to a burn injury vary by gender. male and female burned subjects (n = 260) were compared on their functional disability, disfigurement, coping responses, social resources, and psychosocial adjustment to a burn injury. both men and women had adjusted psychosocially to their burn injury. less functional disability (r = .57, p less than .001) for men and greater problem-solving (r = .57, p less than ...	2010	2964678
atrial natriuretic factor during head-out immersion at night.	the present investigation was undertaken to test the hypothesis that a circadian variation in the atrial natriuretic factor (anf) response is responsible for the nocturnal inhibition of renal responses to head-out immersion (hoi). plasma anf responses to a 3-h hoi (water temperature 34.5 +/- 0.5 degrees c) were studied during day (1000-1300) and night (2400-0300) in six hydropenic male human subjects. in agreement with the previous observations, the renal responses, especially the diuresis, to h ...	1988	2964206
protective immunity against vibrio cholerae infection in the rabbit.	the dic model (duodenal inoculation with ligation of the cecum in rabbits) was employed to study experimentally induced cholera and the related protective immunity. duodenal inoculation (di) without ligation of the cecum with live v. cholerae organisms did not cause any disease symptom but induced protection against subsequent challenges with homologous and heterologous organisms for up to 24 months. after 30 months this protective immunity began to decrease. a similar protective immunity could ...	1987	2964158
[physiological research in tadzhikistan].		2010	2963767
effect of route of administration on the pharmacokinetics of etretinate in the dog.		1988	2963666
identification of a unique lymphocyte subpopulation in the sheep uterus.	a panel of monoclonal antibodies was used to define the lymphocyte subpopulations in the sheep uterus at various stages of the oestrous cycle. a striking finding was that the majority of lymphocytes in the uterine and endometrial glandular epithelia belonged to a unique lymphocyte subpopulation that expressed the cd45r antigen but was negative for major histocompatibility complex (mhc) class ii molecules and expressed low or undetectable levels of the cd5 antigen. when examined under the electro ...	1988	2962930
comparison of prophylactic tetracycline and clioquinol in a rabbit model of intestinal infection with vibrio cholerae and escherichia coli.	the ability of tetracycline and clioquinol to prevent intestinal colonization of vibrio cholerae and escherichia coli was tested in a rabbit model. in the model 10(10) bacteria are given via oro-gastric tube following intravenous cimetidine and oral sodium bicarbonate and prior to intraperitoneal tincture of opium. eighteen hours after challenge the rabbits are sacrificed, and the numbers of the challenge strain remaining in the jejunum and ileum are determined. tetracycline interrupted the inte ...	1987	2962838
service delivery mechanisms in rehabilitation technology.	rehabilitation technology is a rapidly advancing area involving professionals from multiple disciplines, including engineers, occupational and physical therapists, speech pathologists, computer programmers, and many others. this paper focuses on the use of computers and other personal assistive devices by disabled persons, but the concepts presented apply to all areas of personal rehabilitation technology. the topics covered include a perspective on the use of advanced technology, technological ...	2010	2962501
time course of recovery of "stunned" myocardium following variable periods of ischemia in conscious and anesthetized dogs.	persistence of regional contractile dysfunction after restoration of blood flow to transiently ischemic myocardium has been well described. to date, most studies have been performed in anesthetized animals. the present investigation compared the time course of recovery of regional segment shortening (percentage of segment shortening) in anesthetized versus conscious dogs subjected to a brief period of total occlusion of the left anterior descending coronary artery. periods of occlusion lasting 5 ...	1987	2959132
percutaneous transluminal angioplasty improves blood pressure and renal function in renovascular hypertension.	thirty-three patients with renal angiographic evidence of significant renal artery stenosis were referred for percutaneous transluminal angioplasty. the indications were poorly controlled hypertension (n = 13) or hypertension associated with deteriorating renal function (n = 20). their mean age was 56 (23-73) years (12 males, 21 females). causes of the renal artery stenosis were fibromuscular dysplasia (n = 8) and atheromatous changes (n = 25). four patients were excluded, three due to technical ...	2010	2958895
chromosome changes in human malignancy, including the acute leukemias in down syndrome.		1987	2958882
[role of blocking antibodies in skin tests for mites].		2010	2958807
medical history as part of disability evaluation.		2003	2957977
percutaneous transluminal coronary angioplasty of a bifurcation narrowing using the kissing wire monorail balloon technique.		2010	2956851
[pathomorphological observations on endemic goiter].		2010	2955911
[role of helper t-lymphocytes in modulating the humoral immune response to cholera enterotoxin].	the role of helper t-lymphocytes in the modulation of humoral immune response to sheep red blood cells with choleragen has been studied in vivo, the populations of cooperating marrow cells, formed in mice under the action of hydrocortisone being used as a model. in adoptive transfer marrow cells, taken from mice on day 12 after thymectomy and from mice previously treated with antithymocyte serum, have proved incapable of humoral immune response. choleragen, similarly to theophylline, normalizes ...	1987	2954344
the balans chair and its semi-kneeling position: an ergonomic comparison with the conventional sitting position.	recently, the balans chair has been introduced with claims that, because of its semi-kneeling position, individuals will experience decreased low-back pain (lbp) as well as improvement in circulation. this study investigated the validity of these claims. twenty healthy subjects were randomly assigned to one of two groups. group 1 subjects sat in the balans chair for a 30-minute study period and then sat in a conventional office chair for an additional 30-minute period. group 2 subjects were stud ...	1987	2954222