Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [requirement of cyclic 3',5'-monophosphate in the production of a permeability increasing factor by vibrio cholerae]. | 1986 | 3018312 | |
| cytotoxic and cytotonic factors produced by campylobacter jejuni, campylobacter coli, and campylobacter laridis. | complete toxigenicity studies were performed on 341 strains of campylobacter spp., including 23 nonhuman isolates. toxin profiles based on both cytotonic and cytotoxic factors were determined after analyzing responses in vero, hela, cho and y-1 cells. suckling mouse assays were consistently negative for all culture filtrates tested. toxin-producing strains were frequently encountered among both the human and nonhuman strains of campylobacter jejuni, c. coli, and c. laridis investigated. strains ... | 1986 | 3018039 |
| the isolation of genomic recombinants for the human apolipoprotein b gene and the mapping of three common dna polymorphisms of the gene--a useful marker for human chromosome 2. | we have used four independently isolated cdna probes for human apolipoprotein b (apo b), to isolate overlapping genomic recombinants for the 3' portion of the apo b gene. the cdna clones and a unique fragment from the genomic recombinant have been used to identify the human apo b gene in dna from a series of rodent x human somatic cell hybrids. our results provide evidence for the assignment of this gene to the short arm of human chromosome 2 (p23-pter). we have used the cdna probes to identify ... | 1986 | 3017840 |
| modification of the hyperthermic response on neuroblastoma cells by camp and sodium butyrate. | the role of adenosine 3',5'-cyclic monophosphate (camp) and sodium butyrate in modifying the effect of heat on murine neuroblastoma cells (nbp2) in culture was evaluated on the criterion of survival. an elevation of cellular camp level by prostaglandin (pg) a2, a stimulator of adenylate cyclase, and 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (r020-1724), an inhibitor of cyclic nucleotide phosphodiesterase, only during heat treatment (43 degrees c and 40 degrees c) was sufficient to enhance t ... | 2011 | 3017539 |
| [analysis of the spectrum of acth-immunoreactive peptides in the brain of inbred mice]. | the acth-immunoreactive peptides (ip) distribution in the acid extract of brain and plasma fractions of c57bl/6, balb/c and f1 (c57bl/6 x balb/c) mice was investigated. ip were isolated by high-performance liquid chromatography. interstrain differences in the ip spectrum were found in intact mice and mice after exposure to stress in the "open-field" test. | 2010 | 3017474 |
| effects of trazodone treatment on alpha-2 adrenoceptor function in depressed patients. | tricyclic antidepressant drugs reduce the sensitivity of alpha 2 adrenoceptors during long-term treatment. in the present study, the alpha 2 adrenergic agonist clonidine was administered to 11 depressed patients before and during treatment with the triazolopyridine antidepressant trazodone (trz). clonidine's ability to decrease blood pressure (bp) and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyleneglycol (mhpg), and to increase sedation and plasma growth hormone ... | 2003 | 3016788 |
| anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters. | aromatic and heterocyclic esters of 1-methyl-4-piperidinol and 1,4-dimethyl-4-piperidinol and aromatic esters of (dialkylamino)alkanols were prepared and evaluated for antiepileptic activity by the maximal electroshock seizure (mes) and subcutaneous pentylenetetrazole seizure threshold (scmet) assays and for minimal central neurotoxicity by the rotorod ataxia test. the most potent compound, namely the 2-phenylbenzoate (57) of 3-(diethylamino)propanol, was slightly more potent than diphenylhydant ... | 1986 | 3016269 |
| stool cyclic amp in diarrhoea due to different causative organisms. | 1985 | 3016069 | |
| the adenosine triphosphate-pyrophosphate isotopic exchange reaction: a tool for determination of tryptophan. | quantitative determination of tryptophan at the picomole level is described, using the atp-[32p]ppi isotopic exchange reaction catalyzed by tryptophanyl-trna synthetase. sensitivity limits of 500 fmol were obtained. the presence of other amino acids at a 1000-fold excess over tryptophan did not interfere significantly with the quantitative determination of tryptophan. the specificity of the reaction was checked using five tryptophan analogs. these analogs did not prevent the determination of try ... | 2010 | 3014918 |
| reversibility of oxygen-induced injury to the alveolar epithelium: an ultrastructural study. | continuous exposure of rabbits to 100% o2 at one atmosphere (1 ata) for 48 h damages the alveolar epithelium increasing its permeability to lipid insoluble molecules. the purpose of this study was to quantify the reversibility of this injury upon resumption of air breathing, using a cytochemical technique. rabbits were exposed to 100% o2 at 1 ata for either 48 or 63 h and then returned to air. cytochrome c (cyt) was instilled into the alveolar space and detected ultrastructurally in the differen ... | 1986 | 3014700 |
| the beta-subunit of follicle-stimulating hormone is deleted in patients with aniridia and wilms' tumour, allowing a further definition of the wagr locus. | one in 10,000 children develops wilms' tumour, an embryonal malignancy of the kidney. although most wilms' tumours are sporadic, a genetic predisposition is associated with aniridia, genito-urinary malformations and mental retardation (the wagr syndrome). patients with this syndrome typically exhibit constitutional deletions involving band p13 of one chromosome 11 homologue. it is likely that these deletions overlap a cluster of separate but closely linked genes that control the development of t ... | 1986 | 3014343 |
| transposable resistance to trimethoprim and 0/129 in vibrio cholerae. | vibrio cholerae biotype el tor strain bm2508, resistant to trimethoprim, 0/129, streptomycin and spectinomycin was isolated from the faeces of a child with severe diarrhoea. resistance to trimethoprim and 0/129 was due to a dihydrofolate reductase type i and resistance to streptomycin-spectinomycin to a 3'',9-aminoglycoside-aminocyclitol adenylyltransferase. the resistance genes were not transferable to escherichia coli and, as inferred from ultracentrifugation in cesium chloride-ethidium bromid ... | 1986 | 3013828 |
| the 'gastrointestinal syndrome' after chemotherapy: inferences from mouse survival time, and from histologically- and clonogenically-defined cell death in intestinal crypts. | 1986 | 3013268 | |
| [response of polymorphonuclear neutrophils to monosodium urate crystals: production of oxygen free radicals]. | 2006 | 3013256 | |
| bacterial protein toxins with latent adp-ribosyl transferases activities. | 1986 | 3012972 | |
| cloning and expression in escherichia coli of a reca-like gene from vibrio cholerae. | a library containing more than 80% of the vibrio cholerae genome was constructed by cloning bamh1 restriction fragments into pbr322. using interspecific complementation of an escherichia coli reca mutant with plasmids containing the gene bank of v. cholerae, a reca-like gene was identified. the recombinant plasmid, designated as pdp145, contained a 1.45 kb segment of v. cholerae dna which codes for a protein of molecular weight 39,000. the product of this gene confers methyl methane sulphonate r ... | 1986 | 3012281 |
| genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (dearing). | in this paper we provide a step by step comparison of the pathogenesis of murine infection caused by reovirus type 3 (dearing) and an antigenic variant (k) selected by its resistance to neutralization with a monoclonal antibody (g5) directed against the t3 hemagglutinin. to show that specific changes in the biologic properties of variant k were due to mutation in the s1 double-stranded rna segment (gene), which encodes the viral hemagglutinin, we generated a reassortant virus ("1 ha k") containi ... | 1986 | 3012122 |
| adrenocortical responses to corticotropin-releasing factor in the rat. | the time course of plasma corticosterone was measured in male sprague-dawley rats whose endogenous release of acth had been blocked following rapid i.v. injections of doses ranging from 0.003 to 10 micrograms corticotropin-releasing factor (crf) per rat and during i.v. infusions at rates ranging from 0.001 to 20 ng crf x min-1 x 100 g body weight-1. the range of the dose-response curve, following rapid injection, extends from 0.01 to 0.37 micrograms crf, whereas it extends over a 20 000-fold ran ... | 1986 | 3011231 |
| iron-histidine stretching raman line and enzymic activities of bovine and bacterial cytochrome c oxidases. | resonance raman spectra of the reduced form of cytochrome c oxidase isolated from bovine heart and the thermophilic bacterium ps3 were investigated in relation to their h+-pumping- and cytochrome-c-oxidizing activities, which were varied by incubating the enzyme at raised temperatures or at alkaline ph at room temperature. for both the bovine and ps3 enzymes, the intensity of the iron-histidine stretching raman line of the ferrous a3 heme (214 cm-1) exhibited an incubation-temperature-dependent ... | 1986 | 3011089 |
| iron-histidine stretching raman line and enzymic activities of bovine and bacterial cytochrome c oxidases. | resonance raman spectra of the reduced form of cytochrome c oxidase isolated from bovine heart and the thermophilic bacterium ps3 were investigated in relation to their h+-pumping- and cytochrome-c-oxidizing activities, which were varied by incubating the enzyme at raised temperatures or at alkaline ph at room temperature. for both the bovine and ps3 enzymes, the intensity of the iron-histidine stretching raman line of the ferrous a3 heme (214 cm-1) exhibited an incubation-temperature-dependent ... | 1986 | 3011089 |
| sequence dependent dna conformations: raman spectroscopic studies and a model of action of restriction enzymes. | raman spectra have been examined to clarify the polymorphic forms of dna, a, b, and z forms. from an analysis we found that the guanine ring breathing vibration is sensitive to its local conformation. examination of nine crystals of guanosine residues in which the local conformations are well established revealed that a guanosine residue with a c3'endo-anti gives a strong line at 666 +/- 2 cm-1, o4'endo-anti at 682 cm-1, c1'exo-anti at 673 cm-1, c2'endo-anti at 677 cm-1 and syn-forms around 625 ... | 2010 | 3010660 |
| maxillary progonoma of infancy. | 2010 | 3009735 | |
| familial human parvovirus infection associated with anemia in siblings with heterozygous beta-thalassemia. | 1986 | 3009639 | |
| activities of deglycosylated thyrotropin at the thyroid membrane receptor-adenylate cyclase system. | a bovine thyrotropin (btsh) preparation was deglycosylated by treatment with anhydrous hydrogen fluoride (hf) in the presence of anisole. the resulting material consisted of tsh derivatives that exhibited different molecular sizes, all smaller than the native hormone. the majority (62%) of the deglycosylated tsh derivatives did not bind to the lectin concanavalin a, while 98% of the native tsh was able to bind. the deglycosylated tsh derivatives bound to the high affinity-high specificity tsh bi ... | 1985 | 3009595 |
| cloning and expression of the exfoliative toxin b gene from staphylococcus aureus. | exfoliative toxin type b is produced by bacteriophage group ii strains of staphylococcus aureus and is a causative agent of staphylococcal scalded-skin syndrome. in addition to exfoliative toxin b, most isolates also produce a bacteriocin and are immune to the action of the bacteriocin. these phenotypes, as well as resistance to cadmium, were lost after elimination of a 37.5-kilobase plasmid, prw001, from s. aureus ut0007. transduction and transformation showed that prw001 carries the structural ... | 1986 | 3009410 |
| evidence for the functional role of monosialoganglioside gm1 in synaptic transmission in the rat hippocampus. | the hippocampal slices were incubated with compounds which hydrolyze, modify or bind with sialic acid containing molecules. the efficiency of synaptic transmission was tested in the presence of these compounds. the size of the evoked extracellularly recorded potential following schaffer collateral stimulation was used as an indicator of synaptic transmission efficiency. sodium periodate (10 mm) and sodium perchlorate (59.2 mm) evoked a reversible (after washout) decrease in the size of the popul ... | 1986 | 3008944 |
| genetic basis of trimethoprim and o/129 resistance in vibrio cholerae. | because of its important consequences on prophylaxis and therapy of cholera and on bacterial identification, we have studied the genetic basis of cross-resistance to trimethoprim and o/129 of strains of vibrio cholerae o1 independently isolated in africa. two classes of bacteria were found. in the first class, the strains were also resistant to ampicillin and kanamycin and to high levels of streptomycin by synthesis of a 3"- or 6-aminoglycoside phosphotransferase. the strains hybridized weakly w ... | 1985 | 3008635 |
| radioisotopic evaluation of adenocarcinoma and solitary cyst of the kidney. | 2010 | 3008536 | |
| near infrared optical monitoring of intact skeletal muscle during hypoxia and hemorrhagic hypotension in cats. | 1985 | 3008518 | |
| [radiation exposure and risk of radon in the room air of swiss houses]. | the radioactive noble gas radon, a member of the natural decay chains of uranium and thorium, enters the indoor environment in regionally highly diverging amounts. subsoil of dwellings, building materials and drinking water are the main sources. in switzerland and in many other countries, exposure of the lung tissue to the short lived radon decay products is the most important component of the radiation dose of the general public. annual doses in areas with crystalline rock of high uranium conte ... | 1986 | 3008463 |
| interest of the dosage of the h.c.g. in the spermatical blood at the moment of the castration for a testicular tumor (about 28 cases 1978-1984). | 2010 | 3008177 | |
| 2-5a analogs as mechanistic probes of the 2-5a system: stereoconfiguration of phosphorothioate analogs of 2-5a markedly influences metabolic stability. | the stereoconfiguration of the diester bond of phosphorothioate analogs of 2-5a strongly influenced lability to enzymatic hydrolysis by cellular and serum phosphodiesterases. bonds containing the sp configuration were extremely resistant to hydrolysis compared to the corresponding rp configuration linkages. the rate of hydrolysis of the diester bond was influenced by chain length of the adenylate oligomer, with a stability ranking of dimer greater than trimer greater than tetramer; as well as by ... | 1985 | 3008174 |
| the interaction of recombinant huifn-gamma 1 and recombinant huifn-alpha 2 on the 2-5a system in two distinct cell types. | 1985 | 3008171 | |
| molecular epidemiology of non-o1 vibrio cholerae and vibrio mimicus in the u.s. gulf coast region. | ten toxigenic vibrio cholerae non-o1 and v. mimicus strains isolated from clinical and environmental sources in the u.s. gulf coast region were examined for genetic relatedness. restriction digest patterns of chromosomal dna and southern blot analysis with a cholera toxin gene probe revealed that the strains exhibited greater genetic divergence than the highly conserved v. cholerae o1 strains isolated from clinical and sewage samples in this region. | 1986 | 3007571 |
| molecular cloning and expression in escherichia coli k-12 of the gene for a hemagglutinin from vibrio cholerae. | using antiserum to the purified soluble hemagglutinin we isolated an escherichia coli k-12 clone expressing the gene for a hemagglutinin from vibrio cholerae 569b. the plasmid present in this clone was designated ppm471. by deletion analysis with both specific restriction endonucleases and bal 31 nuclease, we localized the gene, to a 0.72-kilobase region of dna, implying a molecular weight of less than 27,000 for the protein. analysis in e. coli k-12 minicells of plasmids containing the cloned g ... | 1986 | 3007362 |
| the role of ethanol in the etiology of primary liver cancer. | 2010 | 3006453 | |
| the role of ethanol in the etiology of primary liver cancer. | 2010 | 3006453 | |
| detection of neoplastic lymph nodes in hodgkin's disease and non-hodgkin lymphoma. comparison between tomography and lymphography. | during a period of 17 months, 98 consecutive patients with malignant lymphoma were examined for initial staging before therapy. both ct and lymphography were performed in 58 patients (19 patients with hodgkin's disease (hd) and 39 patients with non-hodgkin lymphoma (nhl], and these were included in the investigation. the results were discrepant in 26 cases where lymph node lesions were detected by only one of the two methods. in 10 patients, 5 with hd and 5 with nhl, the positive finding by one ... | 2010 | 3006438 |
| distribution of type d retrovirus sequences in tissues of macaques with simian acquired immune deficiency and retroperitoneal fibromatosis. | horizontally acquired saids retrovirus type 2 (srv-2), a type d retrovirus related to the mason-pfizer monkey virus, has been associated with the simian acquired immunodeficiency syndrome (saids) including retroperitoneal fibromatosis (rf) in several macaque species at two primate research centers. virus specific gene sequences are present in lymphoid and rf tissues but not in muscle tissue of diseased macaques or in any tissues of uninfected normal monkeys. serologic and restriction endonucleas ... | 1986 | 3006332 |
| effects of anethole dithiolthione and 2(3)-tert-butyl-4-hydroxyanisole on schistosome granuloma formation. | administration of the antioxidants 2(3)-tert-butyl-4-hydroxyanisole (bha) or 5-(p-methoxyphenyl)-3h-1,2-dithiol-3-thione (adt) to female cd-1 mice starting 4 weeks after infection with 70 cercariae of schistosoma mansoni resulted in a decrease in the size of the inner fibrotic region of the hepatic granuloma. the cellular composition of the granuloma was not altered by treatment with these two compounds. the administration of the specific superoxide scavenger copper diisopropylsalicylate (cudips ... | 1985 | 3005948 |
| effects of anethole dithiolthione and 2(3)-tert-butyl-4-hydroxyanisole on schistosome granuloma formation. | administration of the antioxidants 2(3)-tert-butyl-4-hydroxyanisole (bha) or 5-(p-methoxyphenyl)-3h-1,2-dithiol-3-thione (adt) to female cd-1 mice starting 4 weeks after infection with 70 cercariae of schistosoma mansoni resulted in a decrease in the size of the inner fibrotic region of the hepatic granuloma. the cellular composition of the granuloma was not altered by treatment with these two compounds. the administration of the specific superoxide scavenger copper diisopropylsalicylate (cudips ... | 1985 | 3005948 |
| arthritis associated with crystals containing calcium. | varying combinations of acute inflammatory and/or chronic degenerative arthritis have been found to be associated with crystals of calcium pyrophosphate dihydrate (cppd) and/or basic calcium phosphates (bcps). since the arthropathies associated with cppds and/or bcps occur in older individuals, while diagnosis and treatment for monosodium urate monohydrate crystal deposition disease (gout) have become extremely precise and effective, joint problems associated with calcium crystals have become mo ... | 2010 | 3005784 |
| ergot alkaloids and central monoaminergic receptors. | the interactions of ergolines and of ergopeptines with dopamine (da), alpha 1 and alpha 2 central adrenoreceptors were studied. ergolines and ergopeptines exert agonist activities at central da receptors and exhibit antiparkinsonian activities in monkeys with unilateral ventromedial tegmental lesions of the brain stem. both ergolines and ergopeptines are used in treatment of parkinson's disease and their therapeutic efficacy, as well as their propensity to develop undesirable side effects is und ... | 1985 | 3005775 |
| meiotic recombination between two polymorphic restriction sites within the beta globin gene cluster. | analysis of beta globin gene haplotypes for prenatal diagnosis of beta thalassaemia has revealed a recombination event within the beta globin gene cluster. both a change in the avaii polymorphic site within the beta globin gene and a change in the phenotype of the beta globin gene were observed. paternity was established by the pedigree analysis of hypervariable 'minisatellite' dna polymorphisms and the most probable explanation of the recombination event is a crossover between the psi beta glob ... | 2010 | 3005579 |
| collagenase activity in skin fibroblasts of patients with amyotrophic lateral sclerosis. | in the current study we have measured collagenase activity released from skin explants and fibroblasts of patients with both guam-type and sporadic amyotrophic lateral sclerosis and controls. the rationale for such a study derives from work reported more than 20 years ago demonstrating abnormalities in skin collagen metabolism in patients with the disease. we were not able to find significant differences in collagenase activity when fibroblasts were compared relative to the total protein secrete ... | 2011 | 3005515 |
| protective effect of interferon on infections with hand, foot, and mouth disease virus in newborn mice. | the protective effect of interferon on infection with coxsackievirus type a 16 (ca-16) or enterovirus type 71 (ev-71) in newborn mice was examined. subcutaneous administration of murine interferon (muifn-alpha/beta) into the infected mice produced a protective effect against infection with ca-16 or ev-71. it was found that the time of administration of muifn was important in relation to the cycle of infection. protection was observed when muifn was given once daily for several days, from one day ... | 1986 | 3005425 |
| functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. | we describe the successful reconstitution of functional interactions between an inhibitory adenylate cyclase-coupled receptor and various nucleotide-binding regulatory proteins in phospholipid vesicles. the receptor is the alpha 2-adrenergic receptor (alpha 2ar) which has been partially purified (approximately 500-5000-fold) from human platelet membranes. the nucleotide-binding regulatory proteins include purified preparations of human erythrocyte ni and ns, bovine retinal transducin and the rec ... | 1986 | 3005307 |
| cloning of the vibrio cholerae reca gene and construction of a vibrio cholerae reca mutant. | a recombinant plasmid carrying the reca gene of vibrio cholerae was isolated from a v. cholerae genomic library, using complementation in escherichia coli. the plasmid complements a reca mutation in e. coli for both resistance to the dna-damaging agent methyl methanesulfonate and recombinational activity in bacteriophage p1 transductions. after determining the approximate location of the reca gene on the cloned dna fragment, we constructed a defined reca mutation by filling in an xbai site locat ... | 1986 | 3005236 |
| alpha 2 adrenoceptors modulate the nociceptive jaw-opening reflex in rats. | the jaw-opening reflex in lightly anesthetized rats induced by intrapulpal (left maxillary) electrical tooth pulp stimulation and quantified by the electromyograms (threshold values) recorded from the ipsilateral digastric muscle was used as the experimental pain index. the threshold for the jaw-opening reflex was significantly elevated by clonidine (12.5 to 50 micrograms/kg, i.v.) and was inversely correlated with the frequency of stimulation. the analgesia elicited by clonidine was antagonized ... | 1986 | 3005019 |
| alpha 2 adrenoceptors modulate the nociceptive jaw-opening reflex in rats. | the jaw-opening reflex in lightly anesthetized rats induced by intrapulpal (left maxillary) electrical tooth pulp stimulation and quantified by the electromyograms (threshold values) recorded from the ipsilateral digastric muscle was used as the experimental pain index. the threshold for the jaw-opening reflex was significantly elevated by clonidine (12.5 to 50 micrograms/kg, i.v.) and was inversely correlated with the frequency of stimulation. the analgesia elicited by clonidine was antagonized ... | 1986 | 3005019 |
| effect of the hyp mutation and diet-induced hyperparathyroidism on renal parathyroid hormone- and forskolin-stimulated adenosine 3',5'-monophosphate production and brush border membrane phosphate transport. | the present study was undertaken to investigate the effect of the hyp mutation and diet-induced hyperparathyroidism on renal responsiveness to pth and forskolin and to determine whether the renal brush border membrane phosphate transport defect is expressed in the vitamin d- and calcium-deficient hyp mouse. our results indicate that pth is a potent activator of camp synthesis in renal slices obtained from vitamin d-replete normal mice and hyp littermates. however, in the mutants, the amount of c ... | 1986 | 3004890 |
| hepatitis b virus (hbv) dna in leucocytes in acquired immune deficiency syndrome (aids). | earlier reported findings of hepatitis b virus (hbv) dna in white blood cells of patients with hepatoma, and in a patient with autoimmune haemolytic anaemia, led to the examination of hbv dna in a series of twenty three patients with acquired immune deficiency syndrome (aids), including nine with opportunistic infections and fourteen with kaposi's sarcoma, by southern blot hybridization method, using 32p labelled hbv dna specific probe obtained by nick translation of hbv dna cloned into plasmid ... | 1985 | 3004832 |
| [the afferent pathway of the hippocampus on participation in acupuncture analgesia. a study of retrograde transport method]. | 1985 | 3004787 | |
| novel retinoid-binding proteins from filarial parasites. | the present study deals with the discovery and partial characterization of specific binding proteins for retinol and retinoic acid from filarial parasites (worms of the superfamily filarioidea), including those from two species of onchocerca. these binding proteins, which are distinct in their physicochemical properties and in the mode of ligand interactions from the host-tissue retinoid-binding proteins, may be involved in the mediation of the putative biological roles of retinoids in the contr ... | 1985 | 3004410 |
| [comparative study of the action of vibrio cholerae enterotoxin, thermolabile escherichia coli toxin and a salmonella typhimurium filtrate on the small intestine of laboratory animals]. | the results of the comparative study of the effects produced by v. cholerae enterotoxin e. coli thermolabile toxin (tl-toxin) and s. typhimurum 415 filtrate on the loops of the small intestine of rabbits and c57bl/6 mice are presented. the results obtained in mice were considerably more uniform than those obtained in rabbits. for the first time the dose-effect curve for v. cholerae enterotoxin and tl-toxin, obtained on both animal species, was found to be bell-shaped. the concentration relations ... | 1985 | 3004071 |
| [cytostatic treatment of pseudomyxoma peritonei]. | clinic, pathomorphology and therapy of pseudomyxoma peritonei are explained and discussed by means of a women of 54 years. the prognosis in former times very bad could be improved by a combination of radical surgery and polychemotherapy. | 2011 | 3004068 |
| interaction of stable prostaglandin endoperoxide analogs u46619 and u44069 with human platelet membranes: coupling of receptors with high-affinity gtpase and adenylate cyclase. | it has been demonstrated using a membrane preparation of human platelets that stable analogs of pgh2, u46619 and u44069, control the activity of adenylate cyclase and a high-affinity hormone-sensitive gtpase. at 10(-8)-10(-6) m, the analogs inhibit the basal activity of adenylate cyclase by 20-25%. with a further rise in u46619 and u44069 concentrations up to 10(-5)-10(-4) m, the inhibition is abolished and adenylate cyclase activity is stimulated in a dose-dependent fashion. in the presence of ... | 1985 | 3003958 |
| characterization of electron transfer and proton translocation activities in trypsin-treated bovine heart mitochondrial cytochrome c oxidase. | bovine heart mitochondrial cytochrome c oxidase has been treated with trypsin in order to investigate the role of components a, b, and c (nomenclature of capaldi) in cytochrome c binding, electron transfer, and proton-pumping activities. cytochrome c oxidase was dispersed in nondenaturing detergent solution (b. ludwig, n. w. downer, and r. a. capaldi (1979) biochemistry 18, 1401) and treated with trypsin. this treatment inhibited electron transfer activity by 9% when compared to a similarly trea ... | 1985 | 3002279 |
| primary cytomegalovirus infection following open heart surgery. | among 674 patients undergoing open heart surgery in 1981-82, 86 (13%) were cytomegalovirus (cmv) antibody-negative when tested by an enzyme-linked immunosorbent assay prior to operation. at follow-up, 54 (67%) of 80 patients restudied had seroconverted after the operation, and 35 of the 54 seroconvertants had been ill with fever and elevated liver enzymes. among the latter 35 patients, 26 demonstrated a significant rise in cmv antibody titre, most often detected in the third week following the o ... | 1985 | 3002147 |
| heterogeneity of n-acetylglucosamine 1-phosphotransferase within mucolipidosis iii. | the primary defect responsible for mucolipidosis iii is a deficiency of udp-n-acetylglucosamine:lysosomal enzyme n-acetylglucosamine 1-phosphotransferase activity (glcnac phosphotransferase). genetic complementation analysis of cultured fibroblasts derived from 12 patients with mucolipidosis iii identified complementation groups a, b, and c (honey, n. k., mueller, o. t., little, l. e., miller, a. l., and shows, t. b. (1982) proc. natl. acad. sci. u.s.a. 79, 7420-7424). the glcnac phosphotransfer ... | 2010 | 3001079 |
| dimethylthiourea consumption reflects h2o2 concentrations and severity of acute lung injury. | even though dimethylthiourea (dmtu) effectively scavenges o2 metabolites in vitro, it is often unclear if scavenging of o2 metabolites is the mechanism by which dmtu decreases tissue injury in biological models. since dmtu not only scavenges o2 metabolites but is also consumed in a dose-response manner following reaction with hydrogen peroxide (h2o2) in vitro, we wondered whether dmtu would also be consumed by o2 metabolites in biological systems and if dmtu consumption would then reflect o2 met ... | 1985 | 3001019 |
| [analysis of epstein-barr virus transformation of human lymphocytes: susceptibility of b lymphocyte subpopulations and differentiation stage of the transformed cells]. | the subpopulations of b lymphocytes in human adult peripheral blood which are susceptible to infection and transformation by epstein-barr virus (ebv), and also the stage of ebv-transformed cells in b cell differentiation lineage were identified. the ebv susceptibility were analyzed by two-color immunofluorescence and colony formation in semisolid agar. surface ig-bearing lymphocytes of 3 major ig classes, igm, igg, and iga, in peripheral blood expressed viral nuclear antigen (ebna) after exposur ... | 1985 | 3000906 |
| [analysis of epstein-barr virus transformation of human lymphocytes: susceptibility of b lymphocyte subpopulations and differentiation stage of the transformed cells]. | the subpopulations of b lymphocytes in human adult peripheral blood which are susceptible to infection and transformation by epstein-barr virus (ebv), and also the stage of ebv-transformed cells in b cell differentiation lineage were identified. the ebv susceptibility were analyzed by two-color immunofluorescence and colony formation in semisolid agar. surface ig-bearing lymphocytes of 3 major ig classes, igm, igg, and iga, in peripheral blood expressed viral nuclear antigen (ebna) after exposur ... | 1985 | 3000906 |
| [determination of serum angiotensin converting enzyme activity in normal children and in children with pulmonary disease]. | 2010 | 3000542 | |
| nad+-dependent conversion of 20-oh-ltb4 to 20-cooh-ltb4 by a cell-free system of human polymorphonuclear leukocytes. | human polymorphonuclear leukocytes, but not mononuclear leukocytes, platelets, or erythrocytes, oxidized 20-hydroxy-leukotriene b4 (20-oh-ltb4) to 20-carboxy-ltb4 (20-cooh-ltb4). 20-oh-ltb4 was quantitatively converted to 20-cooh-ltb4 by the sonicate of polymorphonuclear leukocytes in the presence of nad+, with an optimal ph of about 7.9. nadp+ could not replace nad+. the conversion was not inhibited by 2 mm pyrazole, a potent inhibitor of alcohol dehydrogenase. when ltb4 was incubated with the ... | 1985 | 3000366 |
| purification of a metalloproteinase inhibitor from human rheumatoid synovial fluid. | a metalloproteinase inhibitor present in human rheumatoid synovial fluid was purified by a combination of heparin-sepharose chromatography, concanavalin a-sepharose chromatography, ion-exchange chromatography and gel filtration. the mr of the purified inhibitor was 28000 by sds/polyacrylamide-gel electrophoresis and 30000 by gel filtration. the inhibitor blocked the activity of the metalloproteinases collagenase, gelatinase and proteoglycanase, but not thermolysin or bacterial collagenase. the s ... | 1985 | 3000352 |
| effect of pyrimidinone treatment on lethal and immunosuppressive murine cytomegalovirus infection. | the 2-amino-5-halo-pyrimidinones, which are potent interferon inducers and antiviral agents, were found to be protective against lethal cytomegalovirus (cmv) challenge in weanling or neonatal mice when administered before virus challenge. this protection was dependent upon the dosage of pyrimidinone administered. weanling mice infected with a sublethal challenge of cmv exhibited moderate to severe immunosuppression as measured by reduced splenic cell blastogenic responses in vitro to the mitogen ... | 1985 | 3000290 |
| acalculous cholecystitis and cytomegalovirus infection in the acquired immunodeficiency syndrome. | 1986 | 3000250 | |
| [comparative efficacy of disinfectants on the poliovirus]. | 2010 | 2999938 | |
| elicitation of conspecific attack or defense in the male rat by intraventricular injection of a gaba agonist or antagonist. | the involvement of central gabaergic mechanisms in the control over offensive and defensive behaviours in the rat was studied using intracerebroventricular injections (5 microliter) of a gaba agonist (thip) or a gaba antagonist (bicuculline methiodide). intracerebroventricular injections of thip (1.25 and 2.5 micrograms) induced attacks and offensive sideways towards an untreated partner, in animals placed in a neutral area where no aggressive reactions occur in controls. social approach behavio ... | 1985 | 2999844 |
| elicitation of conspecific attack or defense in the male rat by intraventricular injection of a gaba agonist or antagonist. | the involvement of central gabaergic mechanisms in the control over offensive and defensive behaviours in the rat was studied using intracerebroventricular injections (5 microliter) of a gaba agonist (thip) or a gaba antagonist (bicuculline methiodide). intracerebroventricular injections of thip (1.25 and 2.5 micrograms) induced attacks and offensive sideways towards an untreated partner, in animals placed in a neutral area where no aggressive reactions occur in controls. social approach behavio ... | 1985 | 2999844 |
| performance of broiler progeny of breeder flocks vaccinated with inactivated oil emulsion malabsorption syndrome virus vaccine. | broiler breeder pullets were vaccinated at 20 to 24 weeks of age with an inactivated, oil emulsion vaccine containing the co8 strain of avian reovirus. the vaccination induced a high and uniform antibody response that peaked 4 to 5 months postvaccination and persisted up to 11 months postvaccination. broiler production parameters in progeny of vaccinated breeders were compared weekly with parameters of the total broiler production. there was a consistent improvement in body weight at processing ... | 1985 | 2999744 |
| performance of broiler progeny of breeder flocks vaccinated with inactivated oil emulsion malabsorption syndrome virus vaccine. | broiler breeder pullets were vaccinated at 20 to 24 weeks of age with an inactivated, oil emulsion vaccine containing the co8 strain of avian reovirus. the vaccination induced a high and uniform antibody response that peaked 4 to 5 months postvaccination and persisted up to 11 months postvaccination. broiler production parameters in progeny of vaccinated breeders were compared weekly with parameters of the total broiler production. there was a consistent improvement in body weight at processing ... | 1985 | 2999744 |
| tryptophanase activity in different toxigenic and nontoxigenic strains of vibrio cholerae: effect of glucose. | tryptophanase activity was measured in eight different toxigenic and nontoxigenic strains of vibrio cholerae (v. cholerae) in presence and absence of inducer tryptophan (2 mm). stimulation of enzyme activity was observed in both toxigenic and nontoxigenic strains of v. cholerae in presence of inducer. tryptophanase activity remained much higher in toxigenic strains than that in nontoxigenic strains. low levels of enzyme activity in nontoxigenic strains could be increased by the addition of exoge ... | 1985 | 2999564 |
| gamma-aminobutyric acid in peripheral tissues. | significant amounts of gamma-aminobutyric acid (gaba), an endogenous amino acid, are present in mammalian peripheral tissues. this finding led to the suggestion that gaba may act as a neurotransmitter in the peripheral nervous system as it does in the central nervous system. this review deals with recent identification of gaba in the autonomic nervous system and the possible functional role of gaba in neuronal and non-neuronal tissues. the identification of gaba in the autonomic nervous system h ... | 1985 | 2999544 |
| activation of camp dependent protein kinase during surfactant release from type ii pneumocytes. | release of surfactant from pulmonary type ii epithelial cells was stimulated by the beta-adrenergic agonist terbutaline and the diterpene forskolin. cytosolic cyclic adenosine monophosphate (camp) concentrations increased significantly following exposure to terbutaline or forskolin and reached maximal levels within 5 min after treatment. terbutaline and forskolin had a synergistic effect on cytosolic camp levels when added simultaneously. camp-dependent protein kinase activity was identified in ... | 1985 | 2998742 |
| the role of monosialoganglioside gm1 in the synaptic plasticity: in vitro study on rat hippocampal slices. | rat hippocampal slices were incubated with neuraminidase from vibrio cholerae. this enzyme liberates sialic acid from polysialogangliosides converting them into monosialoganglioside gm1. thus, the tissue is enriched in gm1 content. another set of slices was incubated with gm1 itself. both treatments increased the magnitude of potentiation of synaptic response recorded from pyramidal cell layer following high frequency stimulation of schaffer collateral-commissural fibers. it is concluded that en ... | 1985 | 2998547 |
| autoxidation reactions of hemoglobin a free from other red cell components: a minimal mechanism. | rates of autoxidation reactions are determined for normal human hemoglobin a preparations which are extensively purified to remove all other redox active red cell components. the effects of superoxide dismutase, catalase, and hydroxyl radical scavengers on the reaction provide evidence for superoxide formation as the rate determing step followed by fast reactions that involve peroxide and hydroxyl radical. these results support a minimum overall mechanism for heme iron(ii) oxidation and dioxygen ... | 1985 | 2998382 |
| [surgery in the treatment of patients with small cell lung cancer]. | the data on surgical and combined treatment of 52 cases of small cell lung cancer are presented and the end results are evaluated. the findings on survival time make the case for surgery as a component of combined treatment of tumor. the best results were obtained in cases of stage i and ii tumor, absence of metastases into intrathoracic lymph nodes, tumor invasion limited to bronchopulmonary lymph nodes or the root of the lung, intermediate cell pattern of small cell lung cancer and surgery fol ... | 2010 | 2998088 |
| [chronic monoarthritis induced by a synovial sarcoma]. | 2010 | 2997898 | |
| [chronic monoarthritis induced by a synovial sarcoma]. | 2010 | 2997898 | |
| filiform polyposis: a manifestation of histiocytosis x. | 2010 | 2997881 | |
| effect of modification of lysine residues of fructose-6-phosphate 2-kinase:fructose-2,6-bisphosphatase with pyridoxal 5'-phosphate. | inactivation of a bifunctional enzyme, fructose-6-p,2-kinase:fructose-2,6-bisphosphatase by pyridoxal 5'-p followed by reduction with nabh4 was studied. fructose-6-p,2-kinase is over 80% inactivated by 2 mm pyridoxal 5'-p. the stoichiometry of the pyridoxyl-p incorporation and the inactivation of the kinase follows a biphasic curve. the first p-pyridoxyl residue incorporated per protomer does not affect fructose-6-p,2-kinase, but the next two p-pyridoxyl incorporation/protomer results in 80% ina ... | 1985 | 2997189 |
| the prognostic value of morphometry in ovarian epithelial tumors of borderline malignancy. | a fully "blind" morphometric analysis was made of 20 ovarian epithelial tumors; 18 of these were of borderline malignancy, one was a well-differentiated adenocarcinoma and one had been categorized as "borderline? malignant?" morphometry correctly identified the adenocarcinoma, which had proved fatal, and the two tumors of borderline malignancy that had directly led to the patients' deaths, as having a "poor" prognosis. one tumor thought to have a "poor" prognosis was associated with long-term su ... | 2010 | 2997053 |
| prolonged treatment with (+/-) propranolol induces supersensitivity to (l)noradrenaline in mesenteric arteries in the rat. | in the isolated perfused mesenteric arteries of the rat, neither (+/-) propranolol (0.1 microm) nor (+/-)isoproterenol (0.05 microm) modified the overflow of dl-[3h]noradrenaline (dl-[3h]na) induced by sympathetic nerve stimulation at either 5 or 10 hz. the blockade of alpha presynaptic receptors with phentolamine (4.7 microm) increased the 3h-transmitter overflow at 5 and 10 hz. (+/-)propranolol (0.1 microm) failed to modify this effect. vasoconstrictor responses to exogenous na or sympathetic ... | 1985 | 2996969 |
| [inheritance and expression of the restrictive activity of plasmids coding ecori restrictase in vibrio cholerae cells]. | recombinant e. coli plasmids are known to be obtained from e. coli cells using the plasmids coding ecor1 restriction endonuclease. these plasmids were shown to possess various chromosomal or plasmid genes. the paper presents data on the construction of conjugative recombinant plasmid psa1002, capable of conjugate transfer into v. cholerae cells. the stable maintenance and inheritance of the plasmid in v. cholerae cells have been demonstrated as well as phenotypic expression of its genes, includi ... | 1985 | 2996656 |
| vitreous surgery in patients with primary neuropathic amyloidosis. | pars plana vitrectomy was performed in 9 patients from the north of sweden because of amyloid deposits of the vitreous. operative technique and post-operative results are presented. | 2010 | 2996285 |
| effect of sodium bicarbonate and tris (tham) infusion on intra- and extracellular acid-base status during experimental uremia in the rat. | the intra- and extracellular acid-base status of nephrectomized rats was determined following infusion of 10 mmol/kg body mass tris (tham) or sodium bicarbonate. the 'mean whole body phi', an overall estimate of the intracellular ph (complementary to the in vivo determined arterial plasma ph) was calculated from the distribution of 14c-labelled 5,5-dimethyl-2,4-oxazolidinedione. for evaluation of buffer effect of tris or sodium bicarbonate, extra- and intracellular bicarbonate concentration was ... | 1985 | 2996195 |
| the biologic significance of the mixed lymphocyte kidney culture in humans. | the mixed lymphocyte kidney culture (mlkc) in humans has been studied in normal and abnormal clinical conditions. human renal cortical cells were extracted by collagenase treatment from the kidneys of "normal" heart-beating cadaver organ donors (n = 13), patients with end-stage renal disease (esrd) at pretransplant bilateral nephrectomy and splenectomy (n = 13), and from irreversibly rejected renal allografts at the time of graft nephrectomy (n = 5). proliferation of peripheral blood t lymphocyt ... | 1985 | 2996186 |
| [comparative diagnosis of recurrent herpetic stomatitis by the methods of immunofluorescence and direct electron microscopy]. | 1985 | 2996184 | |
| dispute over access to reye's study data. | 2010 | 2996130 | |
| a nonsteroid anti-inflammatory drug exacerbates coxsackie b3 murine myocarditis. | nonsteroid anti-inflammatory drugs are often used to treat myalgias and arthralgias in enteroviral infections, but their effects on acute viral myocarditis are unknown. the effect of the nonsteroidal anti-inflammatory drug, ibuprofen, on acute viral myocarditis was studied in 75 four week old male balb/c mice infected with 1.75 x 10(7) plaque-forming units of coxsackie virus b3 on day 0. ibuprofen was given intraperitoneally at a dose of 15 mg/kg body weight daily. the mice were assigned to four ... | 1985 | 2995470 |
| new medium for the production of cholera toxin by vibrio cholerae o1 biotype el tor. | a new medium that stimulates in vitro production of cholera toxin by vibrio cholerae o1 el tor (el tor vibrios) was developed. the medium contains 0.5% nacl, 0.3% nahco3, 0.4% yeast extract, and 1.5% bacto-peptone. el tor vibrios were cultured in a stationary test tube at 37 degrees c for 20 h. the culture supernatant was assayed for cholera toxin by a reversed passive latex agglutination method. most vibrios grown in this medium produced 10 to 20 times more toxin than in traditional syncase med ... | 1985 | 2995438 |
| effect of naloxone on the hormone response to crf in normal man. | ovine corticotropin releasing factor (crf) was administered to six normal men and the plasma acth and cortisol responses compared with those following the same dose of crf (200 micrograms) plus the opiate receptor blocker naloxone (20mg). the addition of naloxone was associated with a significant increase in plasma acth, cortisol and aldosterone responses. no change was observed in peripheral plasma levels of epinephrine, norepinephrine, arginine vasopressin, angiotensin ii or renin activity in ... | 1985 | 2995021 |
| monoclonal antibodies for the diagnosis of sexually transmitted diseases. | monoclonal antibodies are already being used for the diagnosis of human sexually transmitted diseases. these antibodies can be used to detect a wide range of microorganisms, including bacteria, parasites, and viruses. for both culture and direct tests, monoclonal antibodies showed patterns of specificity and reproducibility that exceeded those available with conventionally prepared antisera. the direct tests for these organisms required less than an hour to perform, representing a major advancem ... | 1985 | 2994946 |
| monoclonal antibodies for the diagnosis of sexually transmitted diseases. | monoclonal antibodies are already being used for the diagnosis of human sexually transmitted diseases. these antibodies can be used to detect a wide range of microorganisms, including bacteria, parasites, and viruses. for both culture and direct tests, monoclonal antibodies showed patterns of specificity and reproducibility that exceeded those available with conventionally prepared antisera. the direct tests for these organisms required less than an hour to perform, representing a major advancem ... | 1985 | 2994946 |
| mn++-stimulated 3h-inositol incorporation in cultured vascular smooth muscle cells: deficiency in cells from spontaneously hypertensive rats. | incubation of cultured dissociated aortic smooth muscle cells from wistar-kyoto rats (wky) with mn++ resulted in a 10-fold stimulation of 3h-myo-inositol incorporation into membrane phospholipid. the stimulation was temperature and energy dependent. the mn++ ec50 was 1 mm and maximum stimulation occurred at 10 mm mn++. other cations were ineffective. in cells from spontaneously hypertensive rats (shr), the mn++ ec50 was unchanged whereas the maximum stimulation of 3h-inositol incorporation was r ... | 1985 | 2994913 |
| specific bindings of prostaglandin d2, e2 and f2 alpha in postmortem human brain. | binding activities specific for each of [3h]prostaglandin (pg) d2, e2 and f2 alpha were detected in the p2 fraction of the human brain homogenates. the bindings were time-dependent, saturable and of high affinity; kd values were 30 nm for all the pg bindings. regional distribution of these binding activities was determined by measuring specific bindings with 10 nm [3h]pg-d2, [3h]pg-e2 and [3h]pg-f2 alpha in the p2 fractions from 17 brain regions. the pg-d2 binding activity was high in the hypoth ... | 1985 | 2994820 |
| comparison of growth hormone binding and metabolic response in rat adipocytes of epididymal, subcutaneous, and retroperitoneal origin. | we undertook a comparison of human growth hormone (hgh) binding and metabolic responses in rat adipocytes of epididymal, subcutaneous, and retroperitoneal origin to determine whether the site of fat depot biopsy might affect the response to hgh stimulation. the results showed highest specific binding in epididymal (3.6%), followed by subcutaneous (2.3%) and retroperitoneal adipocytes (1.5%); half-maximal binding was achieved at 14-18 ng/ml hgh for the three sites. scatchard analysis of the bindi ... | 1985 | 2994338 |
| hemophilia and acquired immune deficiency syndrome. | 1985 | 2994104 |