Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| sensitivity and specificity of microscopic examination of gallbladder bile for gallstone recognition and identification. | during cholecystectomy, gallbladder bile and gallstones were obtained from 77 patients and gallbladder bile was obtained from 39 patients free of stones (11 patients had biliary stenosis). according to their chemical composition, gallstones were classified as cholesterol (n = 46) or pigment (n = 31) stones. in patients with gallstones (a) cholesterol crystals better helped to identify cholesterol gallstones (sensitivity, 87%; specificity, 97%; positive predictive value, 97%) than did an abnormal ... | 2011 | 3049219 |
| the role of heterochromatin in the origin of isochromosome 1 in neoplastic cells. | 1988 | 3049113 | |
| abdominal cryptococcoma in aids: a case report. | cryptococcosis is a recognized opportunistic pathogen in the acquired immune deficiency syndrome. although central nervous system infection and disseminated cryptococcosis is common in acquired immune deficiency syndrome, localized infection is rare. we present a case of massive retroperitoneal and mesenteric adenopathy in a male homosexual patient with acquired immune deficiency syndrome with clinical and radiologic features suggestive of lymphoma. however, this was proven pathologically to rep ... | 1988 | 3048904 |
| national institutes of health consensus statement. health implications of smokeless tobacco use. nih consensus development panel. | national data indicate that at least 10 million persons have used smokeless tobacco within the past year. the human evidence that use of snuff causes cancer of the mouth is strong. smokeless tobacco use increases the frequency of localized gum recession and leukoplakia where the snuff is usually placed. the presence of lead in smokeless tobacco may pose a special risk for the developing fetus. use of smokeless tobacco releases nicotine into the bloodstream and produces blood levels of nicotine c ... | 1988 | 3048429 |
| porcine muscle prolyl endopeptidase: limited proteolysis of tryptic peptides from hemoglobin beta-chains at prolyl and alanyl bonds. | tryptic peptides from hemoglobin (hb) beta-chains were used as model substrates for limited proteolysis by prolyl endopeptidase (ec 3.4.21.26) from porcine muscle. from the physicochemical and enzymatic properties of prolyl endopeptidase the conditions for routine digestion were established as follows: the molar ratio of enzyme to substrate was 1 to 100, and the reaction was carried out in sodium phosphate buffer (ph 6.4) at 37 degrees c for 4 h. under these conditions the peptide bonds on the c ... | 1988 | 3048412 |
| porcine muscle prolyl endopeptidase: limited proteolysis of tryptic peptides from hemoglobin beta-chains at prolyl and alanyl bonds. | tryptic peptides from hemoglobin (hb) beta-chains were used as model substrates for limited proteolysis by prolyl endopeptidase (ec 3.4.21.26) from porcine muscle. from the physicochemical and enzymatic properties of prolyl endopeptidase the conditions for routine digestion were established as follows: the molar ratio of enzyme to substrate was 1 to 100, and the reaction was carried out in sodium phosphate buffer (ph 6.4) at 37 degrees c for 4 h. under these conditions the peptide bonds on the c ... | 1988 | 3048412 |
| bimaxillary proclination in patients of afro-caribbean origin. | the facial morphology of the afro-caribbean negro is reviewed and the aims of treatment for bimaxillary proclination and its subsequent stability are discussed. treatment approaches to various clinical situations are described, together with their known limitations. | 2011 | 3048380 |
| pulmonary involvement in ulcerative colitis. | pulmonary involvement in ulcerative colitis usually presents as a rapidly progressive cough with copious amounts of sputum. although it is rare, distressing symptoms may be relieved by inhaled steroids in 50-60% of cases. three case reports are presented along with a review of the features of 28 other cases. | 2011 | 3048360 |
| past and present strategies of research on the hpa-axis in psychiatry. | hypercortisolism in depression has been extensively studied during the last three decades. the main hypothesis regarding origin and clinical relevance of this phenomenon, however, has changed significantly. up to the mid-seventies hypercortisolism was conceived as consequence of stress modified by the degree of unconscious defense mechanisms in different forms of depressive or non-depressive psychiatric disorders. at the end of the seventies this point of view changed considerably. hypercortisol ... | 2010 | 3048048 |
| panic disorder, cardiology patients, and atypical chest pain. | although patients with angiographically normal coronary arteries have low mortality, several studies have indicated that their social and work morbidity is high. panic disorder appears to be a major contributor to the continuing chest pain in this population. there are also many chest pain patients appearing in cardiology clinics who also do not have heart disease but who are not given the opportunity to be evaluated for psychiatric disorders. among those presenting with atypical or nonanginal c ... | 2010 | 3047707 |
| the nucleotide sequence and gene organization of red clover necrotic mosaic virus rna-2. | red clover necrotic mosaic virus, a member of the dianthovirus group, is characterized by a genome composed of two nonhomologous single-stranded rnas of approximately 4.0 (rna-1) and 1.4 kb (rna-2). the complete nucleotide sequence of the rna-2 has been determined. rna-2 is 1448 nucleotides in length with a 5' terminal m7g cap and no 3' terminal poly-a tail or 5' terminal vpg. an open reading frame beginning at the first initiation codon at nucleotide 80 and ending at nucleotide 1030 has been id ... | 1988 | 3047682 |
| [the role of the rs1 sequence of vibrio cholerae in the amplification of a segment of plasmid dna carrying the tetracycline resistance gene and cholera toxin genes]. | the clones with 4 to 30-fold increased level of tetracycline resistance (tcr) were selected from the strain of escherichia coli k-12 carrying the pco107 plasmid. the plasmid is the cointegrate formed from the plasmids pox38 (f-derivative) and pct105 (pbr322-derivative carrying the vct operon of vibrio cholerae eltor and the rsi sequence). pco107 contains rsi at the junctions of two plasmid genomes. using restriction analysis and southern blot hybridization technique it was shown that increased t ... | 1988 | 3047003 |
| melbourne trial of adjuvant immunotherapy in operable large bowel cancer. | a controlled randomized clinical trial was undertaken to assess the ability of combined non-specific and specific immunotherapy to alter the disease-free interval and overall survival of patients with stage b or c large bowel cancer. the immunotherapy consisted of a 2 year programme of vaccinations with bcg and neuraminidase-treated autologous tumour cells. three hundred and one patients entered the trial. at 5 years of follow-up there is no evidence that this form of immunotherapy can alter eit ... | 1988 | 3046593 |
| [the protective properties of myelopeptides in the development of infectious processes caused by bacteria of the genus salmonella]. | the protective properties of myelopeptides in the development of bacterial infection in mice and young pigs, caused by s. typhimurium 415, s. cholerae-suis 1422 and 370, have been studied. myelopeptides have been found to possess protective properties when injected into animals infected with s. typhimurium and s. cholerae-suis in lethal doses. the best protective effect (survival rate of 100%) has been achieved by the injection of myelopeptides 24 hours before challenge. myelopeptides have also ... | 1988 | 3046197 |
| [use of quantitative immunofluorescence for determining the adsorption capacity of magnetic immunosorbents]. | the adsorption capacity of microgranulated polyacrylamide magnetic immunosorbents has been studied by the method of quantitative immunofluorescence as applied to the causative agents of plague, cholera, and melioidosis. similar regularity in the dynamics of antigen adsorption on the granules of magnetic immunoadsorbents has been established. this regularity consists in the direct relationship between this process and the concentration of infective agents interacting with magnetic sorbents. | 1988 | 3046196 |
| [silanization of the adhesive bridge attachments]. | 2011 | 3046175 | |
| history of discoveries of malaria parasites and of their life cycles. | 1988 | 3045856 | |
| primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. | endothelin is a potent vasoconstrictor/pressor peptide, which we recently characterized from the conditioned culture medium of porcine aortic endothelial cells. we report here the cloning and partial sequencing of the rat endothelin gene. the nucleotide sequence predicted a 21-residue peptide similar to, but distinct from, porcine endothelin; 15 residues of rat endothelin were identical and 3 residues were substitutions by chemically similar amino acid residues to those in the porcine peptide. s ... | 1988 | 3045827 |
| erythematous gingival enlargement in diabetic patients: a report of four cases. | 2011 | 3045273 | |
| regulation of glucose homeostasis in rat jejunum by despentapeptide-insulin in vitro. | the regulation of the absorption and metabolism of glucose in rat small intestine by insulin was studied by the perfusion of isolated loops of proximal jejunum in vitro. the addition of an active, monomeric form of insulin, despentapeptide-insulin, to the serosal side of the intestine from normal rats inhibited luminal glucose absorption (421 (11) to 285 (11) mumol/h/g dry wt, p less than 0.001) and lactate production (340 (28) to 192 (26) mumol/h/g dry wt, p less than 0.001), but had no effect ... | 1988 | 3044931 |
| [congenital hypoplastic left ventricle--a case report]. | a case of congenital hypoplasia of left heart ventricle is presented with regard to its clinical and pathophysiological aspects. a detailed prenatal ultrasonic or echocardiographic diagnosis seems to be absolutely necessary. each sonographer should at least be able to advise of any suspicion of fetal heart abnormalities. | 2010 | 3043980 |
| [congenital hypoplastic left ventricle--a case report]. | a case of congenital hypoplasia of left heart ventricle is presented with regard to its clinical and pathophysiological aspects. a detailed prenatal ultrasonic or echocardiographic diagnosis seems to be absolutely necessary. each sonographer should at least be able to advise of any suspicion of fetal heart abnormalities. | 2010 | 3043980 |
| [x-ray computed tomography in venous pathology]. | after presenting the tomodensitometric semiology of venous thromboses in various territories, the authors define its indications. it is essentially in deep territories, head, chest and abdomen that the ct-scan is used to study and diagnose unrecognized thromboses as well as determine the venous repercussion of various neighboring ailments. the respective place of the ct-scan, ultrasonography and various phlebographies is analyzed. | 2011 | 3043474 |
| prostaglandins and the release of insulin. a review and a proposal. | the effect of prostaglandins or the inhibition of their synthesis on the release of insulin is controversial. dispute exists because there are apparently disparate experimental results. when the following factors are considered, however, much of the disparity is eliminated: 1) the experimental setting--in vitro or in vivo; 2) the experimental model--animal or human; 3) the experimental additive--the type of nonsteroidal antiinflammatory drug or specific prostaglandin; 4) the relationship of insu ... | 1988 | 3043468 |
| a glycolipid precursor of bacterial lipopolysaccharide (lipid x) lacks activity against endothelial cells in vitro and is not toxic in vivo. | lipid x (2,3-diacylglucosamine-1-phosphate) accumulates in mutants of escherichia coli incapable of assembling the disaccharide backbone of lipid a, the principle endotoxic moiety of bacterial lipopolysaccharide (lps). we compared the effects of lipid x on cultured bovine aortic endothelial cell (bec) viability and prostacyclin (pgi2) release with those of lipid a and lps. at 10(-5) m, both lps and lipid a produced significant bec cytotoxicity (percentage cytotoxicity 69 +/- 4 for lps and 51 +/- ... | 1988 | 3043110 |
| correlations between gingival crevicular fluid enzymes and the subgingival microflora. | bacteroides gingivalis is a gram-negative micro-organism implicated in the pathogenesis of adult periodontitis and producing relatively large amounts of specific enzymes. in the present study, subgingival samples taken from adults with moderate periodontitis were examined for the presence and relative amounts of enzymatic activity toward certain substrates. enzyme levels were then correlated with clinical periodontal indices and microbiological analysis of subgingival plaque, including darkfield ... | 1988 | 3042823 |
| may non-invasive methods replace catheterization in quantification of aortic stenosis? | 2011 | 3042401 | |
| [2 cases of creutzfeldt-jacob disease with bilateral vocal cord paralysis]. | 2009 | 3042238 | |
| metabolic effects of continuous subcutaneous insulin infusion: evidence that a rise and fall of portal vein insulin concentration with each major meal facilitates post-absorptive glycemic control. | eighteen lean adult volunteers with insulin-requiring diabetes mellitus attempted to achieve normoglycemia using continuous subcutaneous insulin infusion (csii) or conventional insulin therapy (cit) in a randomized crossover trial of 68 +/- 2.5 weeks (mean +/- sem) duration. as reported (diabetes care 8: 447-55, 1985) the group with absent to low beta-cell function (c-peptide negative, n = 11) attained mean post-absorptive normoglycemia only during csii vs cit (p less than 0.05). only following ... | 2011 | 3042215 |
| acute soft-tissue injuries in the young athlete. | although the incidence of soft-tissue injury is high in the young athlete, one must be constantly aware of the tendency toward epiphyseal and apophyseal injuries in individuals with open growth plates. after the diagnosis of a soft-tissue injury (sprain, strain, or contusion) has been made, treatment must include an initial 24- to 48-hour period of rice. appropriate splinting may be required. rehabilitation then proceeds aggressively, with early restoration of strength, flexibility, and joint ra ... | 2011 | 3042162 |
| [ability of cholestyramine to bind escherichia coli and vibrio cholerae toxins]. | cholestyramine treatment of new born's infectious diarrhea has been shown to be effective. the study of in vitro binding of bacterial toxins from vibrio cholerae and from three strains of escherichia coli suggest an ionic adsorption of the four toxins to this anion-exchange resin. this immediate binding is effective at the ph of intestinal fluid, therefore the protection of the enterocytes from the biological action of the toxins result of the toxins sequestering effect of the cholestyramine. | 1988 | 3041907 |
| the benzodiazepine receptor inverse agonists fg 7142 and ro 15-4513 both reverse some of the behavioral effects of ethanol in a holeboard test. | the intrinsic effect of the benzodiazepine receptor inverse agonists ro 15-4513 and fg 7142 on the behavior of mice in a holeboard were investigated. both drugs caused dose-related decreases in exploratory head-dipping. the highest dose of fg 7142 (40 mg/kg) also reduced locomotor activity. ro 15-4513 (1.5 and 3.0 mg/kg) and fg 7142 (10 and 20 mg/kg) reversed the reductions in the number of head-dips caused by ethanol (2 g/kg). the higher doses of these two drugs also partially reversed the loco ... | 2011 | 3041144 |
| examination of cardiac alpha-adrenoceptors from pharmacological responses and radioligand binding. comparison of rat and guinea pig tissues. | the object of this study was to determine suitable experimental conditions for the pharmacological evaluation of cardiac alpha-adrenoceptors. atrial and ventricular preparations of the guinea pig and rat were employed, and the alpha-adrenoceptor responsiveness was compared with the binding of the alpha-adrenoceptor radioligand [3h]prazosin in membranes prepared from these cardiac regions. the experimental variables examined were the pacing frequency, bath temperature, choice of agonist, and card ... | 1987 | 3041119 |
| preferential repair of n-acetoxy-acetylaminofluorene lesions in the nuclease-hypersensitive region of simian virus 40. | we exposed simian virus 40-infected cv-1 monkey cells to the carcinogen n-acetoxy-acetylaminofluorene and monitored the removal of lesions from cellular dna and from various regions of viral dna. exposure to 5.5 microm 3h-labeled carcinogen produced 20-80 adducts per 10(6) bases in cellular dna in different experiments. the initial adduct concentration in viral dna was always approximately half that in cellular dna. at various times after treatment, cellular and viral dna, and restriction fragme ... | 1987 | 3040723 |
| comparative organization of nitrogen fixation-specific genes from azotobacter vinelandii and klebsiella pneumoniae: dna sequence of the nifusv genes. | in the facultative anaerobe klebsiella pneumoniae 17 nitrogen fixation-specific genes (nif genes) have been identified. homologs to 12 of these genes have now been isolated from the aerobic diazotroph azotobacter vinelandii. comparative studies have indicated that these diverse microorganisms share striking similarities in the genetic organization of their nif genes and in the primary structure of their individual nif gene products. in this study the complete nucleotide sequence of the nifusv ge ... | 1987 | 3040672 |
| opioid neuronal denervation in gilles de la tourette syndrome. | increased striatal dopaminergic functions with heightened postsynaptic receptor sensitivity has been proposed to underlie the major clinical symptoms of tourette's syndrome (ts). the beneficial response of the majority of ts patients to haloperidol supports the hyperdopaminergic pathophysiological concept of ts. however, in 5 recently encountered ts patients, haloperidol failed to ameliorate self-injurious behavior (sib) while the opiate antagonist, naloxone, attenuated sib, implicating deranged ... | 2010 | 3040612 |
| opioid neuronal denervation in gilles de la tourette syndrome. | increased striatal dopaminergic functions with heightened postsynaptic receptor sensitivity has been proposed to underlie the major clinical symptoms of tourette's syndrome (ts). the beneficial response of the majority of ts patients to haloperidol supports the hyperdopaminergic pathophysiological concept of ts. however, in 5 recently encountered ts patients, haloperidol failed to ameliorate self-injurious behavior (sib) while the opiate antagonist, naloxone, attenuated sib, implicating deranged ... | 2010 | 3040612 |
| etoposide combination therapy for small cell carcinoma of the lung. | sixty-three consecutive patients with small cell carcinoma of the lung were treated by six cycles at 3-week intervals of etoposide 120 mg/m2 i.v. on day 1 and orally on days 2-5, adriamycin 40 mg/m2 i.v. on day 1 and vincristine 1.4 mg/m2 i.v. on day 1. tumour bed irradiation was administered to patients with limited disease after chemotherapy. in limited-disease and extensive-disease patients the median survival was 12 and 6 months respectively. the 2-year survival rate (life table) in limited- ... | 2011 | 3040288 |
| site-specific recombination intermediates trapped with suicide substrates. | a family of novel substrates was designed to enable the efficient accumulation of intermediates in site-specific recombination. strategically placed nicks allow these "suicide substrates" to initiate the reaction but prevent its completion or reversal. consequently, it has been possible to determine that lambda site-specific recombination proceeds by a pair of sequential single-strand exchanges. these results rule out that class of models invoking a concerted cutting of all four dna strands. the ... | 2011 | 3040260 |
| directly observed 15n nmr spectra of uniformly enriched proteins. | the proteins cytochrome c2, cytochrome c', and ribulosebisphosphate carboxylase/oxygenase from rhodospirillum rubrum were enriched in 15n by growth of the organism on 15nh4cl. the proteins were purified to homogeneity and studied by 15n nmr. longitudinal and transverse relaxation times as well as the nuclear overhauser effects were determined for various groups of the proteins which vary in molecular weight from 13,000 to 114,000. the values of these parameters for the amide resonances or for gr ... | 1987 | 3040083 |
| [current role of radionuclide imaging in pediatric cardiology]. | three main nuclear medicine methods are used in paediatric cardiology: sequential first-pass radionuclide imaging of the cardiac cavities, radionuclide equilibrium ventriculography and radionuclide myocardial imaging. valuable functional information is obtained, and invasive explorations can be avoided in an ever increasing number of cases. of particular interest is left-to-right shunt measurement which indicates that atrial septal defects must be surgically corrected when the pulmonary/systemic ... | 2011 | 3039935 |
| the choice of opioid receptor subtype in isolated preparations by ohmefentanyl. | ohmefentanyl has significant inhibitory actions on the electrically evoked contractions of guinea pig ileum and mouse vas deferens. their ic50 values are 0.15 nm and 0.89 nm, respectively. in the guinea pig ileum and the mouse vas deferens, both mu-antagonist naloxone and (mu + kappa)-antagonist mr. 2266 antagonize readily the agonist action of ohmefentanyl, indicating that ohmefentanyl acts on mu-receptors in the guinea pig ileum and the mouse vas deferens. like other mu-agonists, ohmefentanyl ... | 1987 | 3039656 |
| antagonist effects of the enantiomers of 3-ppp towards alpha 1-adrenoceptors coupled to inositol phospholipid breakdown in the rat cerebral cortex. | the effects of the two enantiomers of 3-ppp upon alpha 1-adrenergic and muscarinic receptors coupled to the inositol phospholipid (pi) breakdown response have been investigated. 3-ppp(-) and 3-ppp(+) were found to antagonize the noradrenaline (10 microm)-stimulated pi breakdown in rat cerebral cortical miniprisms with ic50 values of 18 and 61 microm, respectively. the dopamine receptor antagonists haloperidol and raclopride were also antagonists, with ic50 values of 0.4 and 25 microm, respective ... | 1987 | 3039482 |
| establishment of a human t-cell hybridoma that produces human macrophage activating factor for superoxide production and translation of messenger rna of the factor in xenopus laevis oocyte. | human monoblast-like histiocytic lymphoma cell line u937 was induced by a macrophage activating factor for o2- production (maf-o) to produce o2- in response to phorbol myristate acetate stimulation. a maf-o-producing human t-cell hybridoma, f4-29-4, was established which was also found to produce macrophage activating factor for glucose consumption (maf-g) and colony stimulating factor (csf) when assayed against mouse bone marrow cells. maf-o could be successfully separated from csf but not from ... | 1987 | 3039355 |
| establishment of a human t-cell hybridoma that produces human macrophage activating factor for superoxide production and translation of messenger rna of the factor in xenopus laevis oocyte. | human monoblast-like histiocytic lymphoma cell line u937 was induced by a macrophage activating factor for o2- production (maf-o) to produce o2- in response to phorbol myristate acetate stimulation. a maf-o-producing human t-cell hybridoma, f4-29-4, was established which was also found to produce macrophage activating factor for glucose consumption (maf-g) and colony stimulating factor (csf) when assayed against mouse bone marrow cells. maf-o could be successfully separated from csf but not from ... | 1987 | 3039355 |
| the nucleotide sequence and genome organization of bovine papillomavirus type 4. | the nucleotide sequence of bovine papillomavirus type 4 (bpv-4) was determined. the viral genome is 7261 base pairs long. several overlapping open reading frames (orfs) have been identified both on the basis of amino acid comparison with other papillomaviruses and on their transcriptional pattern. eight early orfs (e1 to 8) were recognized, coding for dna replication and cell transformation functions, and three late orfs (l1 to 3), coding for structural proteins. like the e5 orf of human papillo ... | 1987 | 3039043 |
| two-year survey of etiologic agents of diarrheal disease at san lazaro hospital, manila, republic of the philippines. | the prevalence of bacterial pathogens and rotavirus in 2,908 patients with diarrhea who were admitted to san lazaro hospital in manila in 1983 and 1984 was determined. one or more enteric pathogens were isolated or detected in samples from 1,698 (58.4%) patients. isolation rates for the various enteropathogens were as follows: rotavirus, 30.6%; shigella spp., 11.6%; salmonella spp., 9.2%; enterotoxigenic escherichia coli (1983 only), 7.8%; vibrio cholerae biotype eltor, 3.8%; non-o1 v. cholerae, ... | 1987 | 3038946 |
| modulation of fibronectin gene expression in chondrocytes by viral transformation and substrate attachment. | chicken vertebral chondrocytes, which normally grow in suspension, synthesize large amounts of cartilage extracellular matrix proteins, but little fibronectin. we have analyzed the effects of both substrate attachment and transformation with a temperature-sensitive mutant of rous sarcoma virus on fibronectin gene expression in these cells. our experiments show that viral transformation increases fibronectin synthesis to a greater extent than substrate attachment. furthermore, transformed chondro ... | 1987 | 3038928 |
| adherence of streptococcus mutans to implant materials. | the adherence of streptococcus mutans omz-176 to six implant materials (poly-crystal alumina, single-crystal alumina, titanium alloy, cobalt-chromium-molybdenum alloy, hydroxyapatite, and heat-curing polymethylmethacrylate resin) was studied in vitro. the change of free energy, which corresponds to the adherence process, was also evaluated for hydrophobic interaction. adherence of s. mutans to poly-crystal alumina was lower than adherence to other materials. the adherence of s. mutans to the tes ... | 1987 | 3038919 |
| complete amino acid sequence of cytochrome c551 from erythrobacter species strain och 114. | the complete amino acid sequence of cytochrome c551 isolated from an aerobic photosynthetic bacterium, erythrobacter sp. strain och 114, was determined. the cytochrome molecule was composed of a total of 119 amino acid residues and its molecular weight including heme was calculated to be 13,235. the sequence was (sequence: see text). its molecular weight indicates that this cytochrome is of the l-type. sequence alignment with other bacterial cytochromes c shows that this cytochrome is similar to ... | 1987 | 3038859 |
| peripheral benzodiazepines enhance the respiratory burst of macrophage-like p388d1 cells stimulated by arachidonic acid. | p388d1, a murine cell with macrophage properties, responds to exogenous arachidonic acid with superoxide anion production. this oxidative burst is enhanced by peripheral and mixed type benzodiazepines and this stimulation is specifically reversed by the peripheral antagonist pk 11195. in contrast, pk 11195 is unable to antagonize a stimulation caused by a non-benzodiazepine ligand such as the chemotactic peptide fmet-leu-phe. the optimal concentrations were close to 10 nm and corresponded to the ... | 2011 | 3038760 |
| evidence for a nigro-pulvinar-lateralis posterior complex projection in the cat using horseradish peroxidase neuronal retrograde technique. | the possible existence of a direct projection from the substantia nigra to the pulvinar-lateral posterior complex (pul-lp) was investigated in the cat by using the horseradish peroxidase technique. in particular horseradish peroxidase was injected in the pul-lp of 8 animals, either unilaterally or bilaterally. tissue sections obtained from the cat's brain 24-48 hrs. after injection were prepared according to mesulam's method as slightly modified by the authors. retrogradelly labelled neurons wer ... | 1987 | 3038046 |
| [computerized tomography imaging of the anterior cardiophrenic angle]. | the anterior cardiophrenic angle (aca) is the lowermost anterolateral portion of the mediastinum. it is limited inferiorly by the diaphragm, anteriorly by the chest wall, posteriorly by the pericardium, and laterally by the parietal pleura. in 20% computed tomography (ct) of the normal aca shows the diaphragm as a linear structure, and in 15% as a pseudotumorous structure that has to be differentiated from real tumours. the inferior sternopericardial ligament appears as a linear structure in 22% ... | 2010 | 3037635 |
| [computerized tomography imaging of the anterior cardiophrenic angle]. | the anterior cardiophrenic angle (aca) is the lowermost anterolateral portion of the mediastinum. it is limited inferiorly by the diaphragm, anteriorly by the chest wall, posteriorly by the pericardium, and laterally by the parietal pleura. in 20% computed tomography (ct) of the normal aca shows the diaphragm as a linear structure, and in 15% as a pseudotumorous structure that has to be differentiated from real tumours. the inferior sternopericardial ligament appears as a linear structure in 22% ... | 2010 | 3037635 |
| selective effects of ect on hypothalamic-pituitary activity. | the hypothesis that ect produces selective effects on hypothalamic-pituitary activity was investigated by determining the effect of ect on pituitary hormone release in nine depressed patients. after ect there were massive and rapid increases in the plasma concentrations of nicotine- and oestrogen-stimulated neurophysin (nsn and esn), prolactin (prl) and adrenocorticotropin (acth), smaller increases in plasma luteinizing hormone (lh) and cortisol, a significant decrease in plasma growth hormone ( ... | 2010 | 3037582 |
| in vivo transcription from multiple spacer rrna gene promoters during early development and evolution of the intergenic spacer in the brine shrimp artemia. | the control of ribosomal rna (rrna) gene expression during development can be productively studied by examination of the relationship between promoter structure and function as well as the processing of primary transcripts. toward this end total cell rna was extracted from embryos at various stages and probed with cloned rrna genes using the "dot blot" method. this exercise showed that rrna gene expression is a stage-specific process and is thus under developmental control. s1 nuclease protectio ... | 2010 | 3037491 |
| in vivo transcription from multiple spacer rrna gene promoters during early development and evolution of the intergenic spacer in the brine shrimp artemia. | the control of ribosomal rna (rrna) gene expression during development can be productively studied by examination of the relationship between promoter structure and function as well as the processing of primary transcripts. toward this end total cell rna was extracted from embryos at various stages and probed with cloned rrna genes using the "dot blot" method. this exercise showed that rrna gene expression is a stage-specific process and is thus under developmental control. s1 nuclease protectio ... | 2010 | 3037491 |
| [construction of recombinant plasmids encoding the biosynthesis of the beta-subunit of cholera toxin]. | the structure of the cholera toxin operon and the location of a and b toxin subunits have been studied by the southern blot hybridization on filters. the gene coding for the synthesis of the cholera toxin b-subunit has been cloned in the vector plasmid pbr322. the structural gene of a-subunit has been partially deleted by the restriction endonuclease bal31 digestion. the size of the 250 b. p. deletion has been defined by electron microscopy. the production of the cholera toxin b-subunit in esche ... | 1987 | 3037359 |
| [decrease of plasma prolactin in valproate therapy--expression of an increase in the activity of the central gabaergic system]. | the effect of valproat on plasma prolactin level in epileptic children with long term medication was investigated. valproat was able to decrease plasma prolactin level significantly. this result is a sign of an increase in the central gabaergic system activity. | 2011 | 3037356 |
| itraconazole treatment of experimental systemic candidiasis in male rats. | after intravenous infection with candida albicans, rats received daily doses of itraconazole for 3 days. all rats receiving 2.5 mg kg-1 day-1 survived while all rats receiving sham-treatment died. with subsequent reduction of the itraconazole dose to 0.63 mg kg-1 day-1, no survival occurred and mortality rates equalled those of the control group. | 1987 | 3037058 |
| itraconazole treatment of experimental systemic candidiasis in male rats. | after intravenous infection with candida albicans, rats received daily doses of itraconazole for 3 days. all rats receiving 2.5 mg kg-1 day-1 survived while all rats receiving sham-treatment died. with subsequent reduction of the itraconazole dose to 0.63 mg kg-1 day-1, no survival occurred and mortality rates equalled those of the control group. | 1987 | 3037058 |
| identification of human rotaviruses in stools from children with gastroenteritis. | 1987 | 3037006 | |
| changes of serum levels of lipid components and apo-lipoproteins after hepatectomy in patients with hepatocellular carcinoma. | 2011 | 3037004 | |
| diethylstilbestrol counteracts barbiturate narcosis and hypothermia in male mice. | treatment with des one hour prior to pentobarbital injection resulted in diminution of the narcotic sleep and hypothermia usually found after pentobarbital (50 mg/kg 1) injection in male mice. the effect was biphasic: significantly countered relative to saline pretreated controls at low (.001-.10 mg/kg 1) and at high (10-50 mg/kg -1) des doses only. giving des alone did not change core body temperature compared to saline injected controls, at either 25 degrees c or at 33 degrees c. at 33 degrees ... | 2011 | 3036728 |
| extracellular proteins of vibrio cholerae: molecular cloning, nucleotide sequence and characterization of the deoxyribonuclease (dnase) together with its periplasmic localization in escherichia coli k-12. | the gene encoding the extracellular dnase of vibrio cholerae was cloned into escherichia coli k-12. a maximal coding region of 1.2 kb and a minimal region of 0.6 kb were determined by transposon mutagenesis and deletion analysis. the nucleotide sequence of this region contained a single open reading frame of 690 bp corresponding to a protein of mr 26,389 with a typical n-terminal signal sequence of 18 aa which, when removed, would give a mature protein of mr 24,163. this is in good agreement wit ... | 1987 | 3036665 |
| isolation of a mouse heat-shock gene (hsp68) by recombinational screening. | we have used cloned fragments from a drosophila melanogaster hsp70 gene and a mouse hsp68 cdna in recombinational screens of mouse genomic libraries. using the mouse probe we have isolated two overlapping recombinant lambda phages comprising 22 kb of cloned dna. southern analysis has localized the homology with the drosophila hsp70 coding region to a 2.2-kb fragment containing the mouse heat-shock gene. insertion accompanying recombinational screening can disrupt interesting sequences; we have o ... | 1987 | 3036653 |
| [expressing plasmid vectors on the basis of escherichia coli beta-galactosidase gene fragments]. | with the use of synthetic dna fragments, a set of new plasmid vectors has been obtained. the vectors provided high level expression of peptides and small proteins in e. coli as fusions with fragments of beta-galactosidase of various length. these vectors were used to achieve expression of a synthetic gene for a functionally active fragment of bacteriorhodopsin. the yields of hybrid proteins consisting of beta-galactosidase and bacteriorhodopsin fragments were in the range of 5-30% from the total ... | 1987 | 3036168 |
| chronic food restriction and the circadian rhythms of pituitary-adrenal hormones, growth hormone and thyroid-stimulating hormone. | adult male sprague-dawley rats were subjected to food restriction so that they ate 65% of food ingested by control rats. while control rats had free access to food over the 24-hour period, food-restricted rats were provided with food daily at 10 a.m. the experimental period lasted for 34 days. on day 35, rats from both experimental groups were killed at 08.00, 11.00, 14.00, 24.00 and 02.00 h. food restriction modified the circadian rhythms of acth and corticosterone. in addition, total circulati ... | 1987 | 3035995 |
| chronic food restriction and the circadian rhythms of pituitary-adrenal hormones, growth hormone and thyroid-stimulating hormone. | adult male sprague-dawley rats were subjected to food restriction so that they ate 65% of food ingested by control rats. while control rats had free access to food over the 24-hour period, food-restricted rats were provided with food daily at 10 a.m. the experimental period lasted for 34 days. on day 35, rats from both experimental groups were killed at 08.00, 11.00, 14.00, 24.00 and 02.00 h. food restriction modified the circadian rhythms of acth and corticosterone. in addition, total circulati ... | 1987 | 3035995 |
| binding studies of dermorphin and its l-form on rat brain opioid receptors. | it is well known dermorphin is a potent and long-acting opioid peptide while its synthetic l-form is almost completely devoid of biological activity. we investigated whether the l-ala2 residue might affect the affinity of the compound for opioid receptors or make [l-ala2] dermorphin more sensitive to metabolic degradation. dermorphin and [l-ala2] dermorphin were assayed in [3h]naloxone binding to opioid receptors in rat brain preparations in the absence and presence of peptidase inhibitors besta ... | 1987 | 3035583 |
| malignant fibrous histiocytoma. | 2010 | 3035462 | |
| malignant fibrous histiocytoma. | 2010 | 3035462 | |
| the effect of chlorhexidine on blood cells. | 2010 | 3035162 | |
| the effect of chlorhexidine on blood cells. | 2010 | 3035162 | |
| confirmation of qualitative research findings in the clinical setting: a strategy to promote research application among baccalaureate nursing students. | 2010 | 3035144 | |
| communicating leveled clinical expectations to nursing students. | nurse educators agree on the need for objectives in the classroom situation and frequently communicate them in a written form. written expectations for clinical, however, are rarely given to student nurses prior to their clinical experience. clinical expectations are understood by instructors, but communicating them to students result in mixed interpretations. the article describes the development of a written method of communicating clinical expectations to solve this problem. this method corre ... | 2010 | 3035139 |
| effect of exogenous gangliosides on amino acid uptake and na+, k+-atpase activity in superior cervical and nodose ganglia of rats. | the effects of some gangliosides on active uptake of nonmetabolizable alpha-aminoisobutyric acid (aib) and na+, k+-atpase and ca2+, mg2+-atpase activities in superior cervical ganglia (scg) and nodose ganglia (ng) excised from adult rats were examined during aerobic incubation at 37 degrees c for 2 h. in ng, amino acid uptake was greatly accelerated with the addition of galactosyl-n-acetylgalactosaminyl-[n-acetylneuraminyl]-galactosylgluc osyl ceramide (gm1) (85%) and also with n-acetylgalactosa ... | 1987 | 3035095 |
| active lambda and kappa antibody gene rearrangement in abelson murine leukemia virus-transformed pre-b cell lines. | the two abelson murine leukemia virus (a-mulv)-transformed cell lines, bm18-4 and abc-1, undergo immunoglobulin l-chain gene recombination during passage in tissue culture. bm18-4 cells are capable of kappa gene recombination, whereas abc-1 cells are capable of both kappa and lambda gene recombination. the expression of h chains is apparently not necessary for continuing l chain gene recombination in either of these cells, although h-chain expression may have been involved in the initiation of l ... | 1987 | 3035056 |
| radiation-induced dna damage and its repair. | application of modern methods of organic chemistry and recombinant dna technologies has provided new insights in the field of dna radiation damage and its repair. an overview of the chemical nature of the lesions inflicted on dna by ionizing radiation is presented. the structures of 29 different dna modified base or sugar residues are shown in comprehensive formation schemes. a fraction of radiation-induced modified bases is spontaneously released from the dna chain during irradiation. another p ... | 1987 | 3034813 |
| radiation-induced dna damage and its repair. | application of modern methods of organic chemistry and recombinant dna technologies has provided new insights in the field of dna radiation damage and its repair. an overview of the chemical nature of the lesions inflicted on dna by ionizing radiation is presented. the structures of 29 different dna modified base or sugar residues are shown in comprehensive formation schemes. a fraction of radiation-induced modified bases is spontaneously released from the dna chain during irradiation. another p ... | 1987 | 3034813 |
| effect of recombinant human interferon gamma against human cytomegalovirus. | escherichia coli-derived human interferon-gamma (rifn-gamma) inhibited the replication of human cytomegalovirus (hcmv) synergistically when combined with ifn-alpha. the induction of hcmv dna polymerase was inhibited in rifn-gamma-treated cells. it is suggested that the induction of 2-5 a synthetase does not play an important role in the anti-hcmv actions of ifns. | 1987 | 3034215 |
| calmodulin-mediated cadmium inhibition of phosphodiesterase activity, in vitro. | ion-stripped bovine brain calmodulin (cam) binds 4 moles cd2+ as well as 4 moles ca2+ per mole protein, with similar affinity; in the presence of 1 mm mg2+ the molar binding ratio of cam for ca2+ decreased to 3, the apparent k0.5 for ca2+ nearly doubled, but the binding characteristics of cam for cd2+ were not changed. saturating concentrations ca2+ did not affect the molar binding ratio of cam for cd2+, but increased the apparent k0.5 for cd2+; vice versa, saturating concentrations cd2+ decreas ... | 1987 | 3034196 |
| molecular cloning of a xylanase gene from bacteroides succinogenes and its expression in escherichia coli. | a gene coding for xylanase synthesis in bacteroides succinogenes was isolated by cloning, with escherichia coli hb101 as the host. after partial digestion of b. succinogenes dna with sau3a, fragments were ligated into the bamhi site of pbr322 and transformed into e. coli hb101. of 14,000 colonies screened, 4 produced clear halos on remazol brilliant blue-xylan agar. plasmids from two stable clones recovered exhibited identical restriction enzyme patterns, with the same 9.4-kilobase-pair (kbp) in ... | 1987 | 3034151 |
| maturation antigen of the mouse sperm flagellum: ii. origin from holocrine cells of the distal caput epididymis. | during epididymal transit, the mouse sperm flagellum acquires a surface glycoprotein (sma4) from epididymal fluid that functions as a sperm antiagglutinin. to determine the origin of this molecule, testes and epididymides of male mice were sectioned for light microscopy and stained with wheat germ agglutinin (wga)-peroxidase, a probe that has been used previously to examine the biology of sma4. wga reactivity was localized to the cytoplasm in a small population of cells in the distal caput epidi ... | 1987 | 3034104 |
| cyclic amp phosphodiesterase in thermomonospora curvata. | cyclic amp phosphodiesterase (pde; ec 3.1.4.17) in thermomonospora curvata was purified and characterized. fractionation of cell extracts by ion-exchange and size-exclusion chromatography revealed four pde isozymes, which differed markedly in molecular weight, theophylline sensitivity, ph optima, and substrate affinity. although the enzyme was labile after purification, total recovery of pde activity was fivefold that of the crude extract. pde biosynthesis appeared sensitive to the growth phase, ... | 1987 | 3032914 |
| stress induced right ventricular dysfunction: an indication of reversible right ventricular ischaemia. | stress induced changes in left ventricular ejection fraction are widely used in the detection and assessment of coronary artery disease. this study demonstrates that right ventricular dysfunction may also occur, and assesses its significance in terms of coronary artery anatomy. this study involved 14 normal subjects and 26 with coronary artery disease investigated by equilibrium radionuclide ventriculography, at rest and during maximal dynamic exercise. mean normal resting right ventricular ejec ... | 2010 | 3032637 |
| stress induced right ventricular dysfunction: an indication of reversible right ventricular ischaemia. | stress induced changes in left ventricular ejection fraction are widely used in the detection and assessment of coronary artery disease. this study demonstrates that right ventricular dysfunction may also occur, and assesses its significance in terms of coronary artery anatomy. this study involved 14 normal subjects and 26 with coronary artery disease investigated by equilibrium radionuclide ventriculography, at rest and during maximal dynamic exercise. mean normal resting right ventricular ejec ... | 2010 | 3032637 |
| presence of gonadotropin-releasing hormone-like proteins in bovine and ovine ovaries. | recently, the rat ovary was shown to contain significant levels of a gnrh-like protein, but no detectable gnrh. in the present studies, extracts of bovine ovaries and ovine corpora lutea were examined for their content of both gnrh-like protein and gnrh. the gnrh-like proteins were detected with a rat ovarian membrane radioreceptor assay, and gnrh was detected with a specific gnrh ria. the biological activity of the gnrh-like protein was evaluated with a rat luteal cell assay. gnrh-like activity ... | 1987 | 3032569 |
| growth hormone-releasing factor-44 specificity for components of somatotroph and lactotroph immediate release pool substructures. | rat somatotroph and lactotroph hormone storage is divisible into at least two functional compartments: an immediate release pool (irp) and a pool that responds to prolonged stimulation. an irp substructure has been defined by release in response to potassium ion (k+), prostaglandin e1 (pge1), and bu2camp. the somatotroph irp is expandable; the lactotroph irp is fixed in size. the present experiments examined which irp components contribute to the rapid release of stored gh in response to gh-rele ... | 1987 | 3032568 |
| role of postnatal gonadal function in the determination of thyrotropin (tsh) releasing hormone-induced tsh response in adult male and female rats. | permanent effects of postnatal gonadal function on the hypothalamo-pituitary-thyroid axis were examined in male and female rats of the wistar-imamichi strain. animals were used at the age of about 10 weeks. neonatally castrated (nc) males showed a significantly higher plasma tsh response to trh (10 micrograms/kg bw, ip) than males castrated at 1, 2, 3, 4, or 6 weeks of age. the tsh response in intact males was similar to that seen in nc males. neonatal androgenization of nc males with 100 microg ... | 1987 | 3032567 |
| membrane phospholipids alter nutrient transport and drug toxicity in tumorigenic fibroblasts. | the phospholipid polar head group composition of lm cell plasma membranes was nutritionally altered by choline analogue supplementation. phosphatidylcholine (pc), normally 60% of total phospholipid, was depleted by 60 to 90% in membranes from cells cultured with n, n'-dimethylethanolamine (dme), n-monomethylethanolamine (me), and ethanolamine (e). enrichment of lm cell membranes with choline analogues, such as dme-, me-, and e-containing phospholipids, decreased the transport of [3h]thymidine, [ ... | 2011 | 3032553 |
| [effect of cholera enterotoxin on carbohydrate metabolism of the liver and small intestine mucosa in the rabbit]. | changes in carbohydrate metabolism were studied in the isolated intestinal loops of rabbits during secretory diarrhea, induced by cholera enterotoxin. glucose synthesis level in the small intestinal mucosa and liver was measured by isotope technique, using l-alanine as a precursor. intestinal gluconeogenesis, calculated per mg of protein, appeared to be twice higher than in the liver of fasting rabbits. cholera enterotoxin administration enhanced gluconeogenesis in the liver by 60%, as compared ... | 1987 | 3032299 |
| evolution of localization of reactions of adenosine triphosphatase (mg++-atp-ase), 5'nucleotidase (5'nt), alkaline phosphatase (ap), and acid phosphatase (acp) in developing rat testis. ii. after cdcl2 treatment. | the described experiments show the influence of a single dose of cadmium chloride (1.5 mg cdcl2/kg body weight applied intraperitoneally) on development of the male gonads from the 1st d of post-fetal life to 1.5 a of life. in the case of the enzymes triggering transportation processes, adenosine triphosphatase stimulated by mg++ (mg++-atp-ase), alkaline phosphatase (ap), and 5'nucleotidase (5'nt), a considerable damages begin to appear in the 15th d of life whereas in the case of acid phosphata ... | 1987 | 3031915 |
| a cellular protein binds to a conserved sequence in the adenovirus type 2 enhancer. | a sensitive gel retention assay has been utilized to detect proteins from uninfected hela nuclei which interact with the adenovirus type 2 enhancer. this assay has been employed to monitor fractionation of nuclear extracts. three enhancer binding factors were resolved by chromatography on deae-sepharose and one of the factors was further purified by chromatography on heparin-sepharose. dnase protection experiments have shown that the heparin-sepharose fraction contains a factor which binds predo ... | 1987 | 3031610 |
| nucleotide sequence of ompv, the gene for a major vibrio cholerae outer membrane protein. | the nucleotide sequence of the ompv gene of vibrio cholerae was determined. the product of the gene is a 28,000 dalton protein which, after the removal of a 19 amino acid signal sequence, produces a mature outer membrane protein of 26,000 daltons. the cleavage site was determined by amino-terminal amino acid sequencing of the purified mature protein. the dna upstream of the gene shows the presence of a typical promoter region as judged from the escherichia coli consensus information; however, th ... | 1986 | 3031428 |
| pharmacological modification of pulmonary vascular injury: possible role of camp. | experiments were designed to test the hypothesis that drugs which increase adenosine 3',5'-cyclic monophosphate (camp) in the lung would prevent the pulmonary hypertension and the increase in vascular permeability caused by the infusion of the oxidant lipid peroxide, tert-butyl hydroperoxide (t-bu-ooh), in isolated rabbit lungs perfused with krebs-henseleit buffer. pretreatment with indomethacin or verapamil was also studied, since these drugs block the increase in pulmonary arterial pressure ca ... | 1987 | 3031002 |
| current concepts in the management of soft tissue sarcomas of the extremities. | in recent years the orthopaedist has become the initial physician to see soft tissue neoplasms. a review of the current concepts of treatment of these lesions, therefore, seems to be in order. | 2010 | 3030471 |
| carbamate kinase of lactobacillus buchneri ncdo110. i. purification and properties. | carbamate kinase has been prepared from lactobacillus buchneri ncdo110. an approximately 91-fold increase in the specific activity of the enzyme was achieved. the purified extract exhibited a single band following polyacrylamide gel electrophoresis. the apparent molecular weight as determined by gel electrophoresis was about 97,000. the enzyme is stable for 2 weeks at -20 degrees c. maximum enzymatic activity was observed at 30 degrees c and ph 5.4 in 0.1 m acetate buffer. l. buchneri carbamate ... | 1986 | 3030360 |
| carbamate kinase of lactobacillus buchneri ncdo110. i. purification and properties. | carbamate kinase has been prepared from lactobacillus buchneri ncdo110. an approximately 91-fold increase in the specific activity of the enzyme was achieved. the purified extract exhibited a single band following polyacrylamide gel electrophoresis. the apparent molecular weight as determined by gel electrophoresis was about 97,000. the enzyme is stable for 2 weeks at -20 degrees c. maximum enzymatic activity was observed at 30 degrees c and ph 5.4 in 0.1 m acetate buffer. l. buchneri carbamate ... | 1986 | 3030360 |
| primary amyloid polyneuropathy with myocardial uptake of technetium-99m-diphosphonate. | 2010 | 3030187 |