Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| in vitro activities of beta-lactam-beta-lactamase inhibitor combinations against stenotrophomonas maltophilia: correlation between methods for testing inhibitory activity, time-kill curves, and bactericidal activity. | the activities of ampicillin, ampicillin-sulbactam, amoxicillin, amoxicillin-clavulanic acid, ticarcillin, ticarcillin-clavulanic acid, piperacillin, piperacillin-tazobactam, aztreonam, and aztreonam-clavulanic against stenotrophomonas maltophilia strains for which the mics of penicillins and commercially available beta-lactam-beta-lactamase inhibitor combinations were higher than the breakpoints usually recommended for pseudomonas aeruginosa in commercially available broth microdilution methods ... | 1997 | 9420028 |
| inhibition of metallo-beta-lactamases by a series of thiol ester derivatives of mercaptophenylacetic acid. | a series of mercaptophenylacetic acid thiol esters bearing a phenyl substituent adjacent to the carboxylic acid function has been shown to be inhibitors of metallo-beta-lactamases. the inhibition of the bacteroides fragilis cfia and bacillus cereus ii metallo-beta-lactamases was zn2- dependent, greater inhibition being observed at 1 microm znso4 than at 100 microm znso4. despite this zn2+ dependency, isothermal titration calorimetry studies illustrated that representative compounds had no detect ... | 1997 | 9418252 |
| [the role of carbapenems in the treatment of nosocomial infection]. | carbapenems are active beta-lactam antibiotics versus most of the gram positive and gram negative microorganisms and anaerobes although their activity is lacking in the case of staphylococcus sp. resistant to methicillin, enterococcus faecium and streptococcus pneumoniae with high resistance to penicillin and some gram negative bacilli which naturally produce an methaloenzyme able to hydrolyze them such as stenotrophomonas maltophilia. imipenem, the first synthetized carbapenem requires administ ... | 1997 | 9410075 |
| [meropenem: microbiologic perspective]. | meropenem is a beta-lactamic carbapenem derived from thienamycin and is structurally characterized by the presence of a beta-methyl group in position c1 which confers stability to the molecule versus renal dehydropeptidase 1 (dhp-1), thereby making the coadministration of an enzyme inhibitor unnecessary. its esterochemical configuration of the lateral chain in c2 (dimethyl carbomoilpyrrolidenethium) increases the activity versus gram negative bacteria (enterobacteria and pseudomonas) and moreove ... | 1997 | 9410064 |
| resistance pattern of 2816 isolates isolated from 17631 blood cultures and etiology of bacteremia and fungemia in a single cancer institution. | the resistance pattern of 2816 isolates from 17631 blood cultures and the etiology of isolates causing bacteremia and fungemia among 14591 admissions were investigated in an 80-bed single cancer institute during seven years (1990-1996) under the same empiric therapeutic antibiotic policy but with different prophylactic strategies. no change was found in the proportion of gram-positive versus gram-negative bacteria isolated from bacteremias (70% vs. 30%) during the past seven years. furthermore, ... | 1997 | 9408157 |
| isolation and characterization of novel iron-oxidizing bacteria that grow at circumneutral ph. | a gel-stabilized gradient method that employed opposing gradients of fe2+ and o2 was used to isolate and characterize two new fe-oxidizing bacteria from a neutral ph, fe(2+)-containing groundwater in michigan. two separate enrichment cultures were obtained, and in each the cells grew in a distinct, rust-colored band in the gel at the oxic-anoxic interface. the cells were tightly associated with the ferric hydroxides. repeated serial dilutions of both enrichments resulted in the isolation of two ... | 1997 | 9406396 |
| antimicrobial activity of 12 broad-spectrum agents tested against 270 nosocomial blood stream infection isolates caused by non-enteric gram-negative bacilli: occurrence of resistance, molecular epidemiology, and screening for metallo-enzymes. | a total of 270 recent nosocomial blood stream isolates of non-enterobacteriaceae gram-negative bacilli representing nearly 50 u.s. medical centers were characterized. the numbers of isolates of individual organisms were: pseudomonas aeruginosa (n = 204), acinetobacter spp. (n = 48), and stenotrophomonas maltophilia (n = 18). mics were determined using the broth microdilution susceptibility method with 12 antimicrobial agents: piperacillin, piperacillin/tazobactam, ceftriaxone, ceftazidime, cefep ... | 1997 | 9401811 |
| transferable antibiotic resistance in nosocomial stenotrophomonas maltophilia strain. | stenotrophomonas maltophilia (298/85) was isolated from the extensively inflamed conjunctiva of a neonate in a regional hospital in ostrava, czech republic. it was resistant to all available antibiotics except cefepime and trimethoprim. the donor s. maltophilia strain 298/85 transferred carbenicillin and cephaloridine resistance determinants to recipient strains of escherichia coli k-12 3110 rif+ and proteus mirabilis p-38 rif+. all transconjugant colonies were co-resistant also to kanamycin, ce ... | 1997 | 9401804 |
| infections in patients with cystic fibrosis following lung transplantation. | there is controversy over whether colonization with drug-resistant organisms is a contraindication to lung transplantation. | 1997 | 9377954 |
| sequence analysis of a 1296-nucleotide plasmid from xylella fastidiosa. | a cryptic plasmid from xylella fastidiosa strain atcc 35868 was cloned, sequenced, and the sequence entered into genbank (u71220). the plasmid is 1296 nucleotides in length with 55% gc content and three open reading frames. a plasmid with sequence homology was found in only one other strain of x. fastidiosa, atcc 35878. searches of the genbank reveal nucleotide sequence homology with plasmid pnkh43 from stenotrophomonas maltophilia, and amino acid sequence homology with phage pf3 from pseudomona ... | 1997 | 9351204 |
| molecular epidemiology of acquisition of ceftazidime-resistant gram-negative bacilli in a nonoutbreak setting. | we prospectively studied the acquisition of ceftazidime-resistant gram-negative bacilli (caz-rgn) in two surgical intensive care units (sicu) during a nonoutbreak period. surveillance cultures were obtained from patients at the time of admission and serially thereafter. caz-rgn isolates were typed by pulsed-field gel electrophoresis (pfge). three hundred and forty-three patients were enrolled from whom 1,621 baseline and follow-up cultures were obtained. the most common species isolated from pat ... | 1997 | 9316915 |
| [bacteremia caused by stenotrophomonas (xanthomonas) maltophila]. | 1997 | 9312285 | |
| cleavage of influenza a virus h1 hemagglutinin by swine respiratory bacterial proteases. | cleavage of influenza a virus hemagglutinin (ha) is required for expression of fusion activity and virus entry into cells. extracellular proteases are responsible for the proteolytic cleavage activation of avirulent avian and mammalian influenza viruses and contribute to pathogenicity and tissue tropism. the relative contributions of host and microbial proteases to cleavage activation in natural infection remain to be established. we examined 23 respiratory bacterial pathogens and 150 aerobic ba ... | 1997 | 9311838 |
| epidemiological typing of stenotrophomonas maltophilia. | stenotrophomonas maltophilia is increasingly recognized as a cause of hospital-acquired infection and respiratory tract colonization in cystic fibrosis patients. a number of methods have been described for the typing of strains in epidemiological studies. pulsed-field gel electrophoresis (pfge) of total chromosomal dna cleaved by low-frequency restriction site endonucleases (xbai, spei) is highly discriminatory and defines populations at the strain level. other molecular methods such as ribotypi ... | 1997 | 9261755 |
| analysis of 553 episodes of monomicrobial bacteraemia in cancer patients: any association between risk factors and outcome to particular pathogen? | relationships between aetiology, various risk factors (such as neutropenia, catheter insertion, endoscopy, therapy with corticosteroids, therapeutic use of antimicrobials, antibiotic prophylaxis, source of infection), symptomatology and outcome were studied in 553 monomicrobial bacteraemic episodes in cancer patients observed within 7 years at the national cancer institute of the slovak republic. the ratio of gram-positive to gram-negative bacteraemia was 1:1 (43.5% vs 43.8%), and yeasts caused ... | 1997 | 9257432 |
| susceptibility testing of stenotrophomonas maltophilia to carbapenems. | the susceptibility of 20 clinical isolates of stenotrophomonas maltophilia to the carbapenems imipenem and meropenem was investigated by various methods. s. maltophilia appeared sensitive to meropenem but resistant to imipenem by disc testing in iso-sensitest agar. agar dilution mics were performed using iso-sensitest agar and with incubation under three sets of atmospheric conditions. mics of meropenem were considerably lower than those of imipenem; this effect was maximal after incubation in 5 ... | 1997 | 9249199 |
| temperature-dependent resistance to gentamicin in graft keratitis by stenotrophomonas (xanthamonas) maltophilia. | 1997 | 9246293 | |
| in vitro antimicrobial activity of ru-59863, a c-7 catechol substituted cephalosporin. | the in vitro activity of ru-59863, a so-called "fifth generation" catechol cephalosporin, was evaluated against 606 bacterial isolates and compared with the activities of cefotaxime, ceftazidime, cefepime, and cefpirome. ru-59863 demonstrated a broad spectrum of inhibition and superior overall activity than comparators when tested against enterobacteriaciae (mic90s, 0.015 to 2 micrograms/ml), pseudomonas aeruginosa (mic90, 0.5 microgram/ml), stenotrophomonas maltophilia (mic90, 0.25 microgram/ml ... | 1997 | 9239501 |
| 16s rrna gene sequence analyses and inter- and intrageneric relationships of xanthomonas species and stenotrophomonas maltophilia. | the nearly complete, pcr-amplified, 16s rrna gene sequences have been determined from the representative type strains of eight xanthomonad phena, including six validly described species of the genus xanthomonas and stenotrophomonas maltophilia. pairwise sequence comparisons and phylogenetic analysis demonstrated that the xanthomonads comprise a monophyletic lineage-within the gamma-subclass of the proteobacteria. although the genus xanthomonas was observed to comprise a cluster of very closely r ... | 1997 | 9228747 |
| infectious crystalline keratopathy caused by gram-negative bacteria. | to identify the characteristics and outcomes of infectious crystalline keratopathy caused by gram-negative bacteria. | 1997 | 9222227 |
| in-vitro activity of trovafloxacin against sensitive and resistant aerobic bacteria using the standard microdilution broth method and etest. | a comparison of mics of trovafloxacin (cp-99,219) determined by the standard microdilution broth method versus the etest was performed for multiple strains of gram-positive and gram-negative bacteria. a comparison was also made of the in-vitro activity of trovafloxacin versus ciprofloxacin and ofloxacin. the mic50 and mic90 were determined by both methods for each species tested. the etest resulted in mics one to two dilutions higher than the microdilution broth method. trovafloxacin was the mos ... | 1997 | 9222068 |
| antibacterial activity of trovafloxacin against nosocomial gram-positive and gram-negative isolates. | a total of 1132 clinical isolates from 952 patients with nosocomial infections were tested against the fluoroquinolone trovafloxacin by the agar dilution method. they comprised 285 staphylococci, 111 streptococci, 94 enterococci and 470 isolates of enterobacteriaceae, 92 pseudomonas aeruginosa, 27 stenotrophomonas maltophilia, 28 haemophilus influenzae and 25 acinetobacter calcoaceticus. the in-vitro activity of trovafloxacin was compared with that of ciprofloxacin, norfloxacin, beta-lactam and ... | 1997 | 9222067 |
| in-vitro activity of trovafloxacin against clinical bacterial isolates from patients with cancer. | the antibacterial activity of trovafloxacin was compared with that of ciprofloxacin, levofloxacin, ofloxacin, sparfloxacin and norfloxacin against bacterial isolates from patients with cancer. in general, the activity of trovafloxacin was comparable to that of ciprofloxacin, levofloxacin and sparfloxacin against most gram-negative isolates tested (minor differences in the activity of each agent against individual species were seen) and it was the most active agent tested against stenotrophomonas ... | 1997 | 9222065 |
| subcutaneous lesions and bacteraemia due to stenotrophomonas maltophilia in three leukaemic patients with neutropenia. | subcutaneous lesions were seen in three of 13 neutropenia patients who had stenotrophomonas (xanthomonas) maltophilia bacteraemia. the characteristic clinical presentation resembled leukaemic infiltrates, and were different from deep ulcers or subcutaneous nodules caused by pseudomonas aeruginosa. the three patients had acute leukaemia and were treated with intensive combination chemotherapy. all had previously been treated with broad-spectrum antibiotics, and each patient recovered after proper ... | 1997 | 9217834 |
| comparative activity of trovafloxacin, alone and in combination with other agents, against gram-negative nonfermentative rods. | in the first part of this study, agar dilution mics were used to test the activities of trovafloxacin, ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin, clinafloxacin, ceftazidime, and imipenem against 458 gram-negative nonfermenters. the overall respective mics at which 50% of isolates are inhibited (mic50s) and mic90s were as follows: trovafloxacin, 1.0 and 16.0 microg/ml; ciprofloxacin, 2.0 and 16.0 microg/ml; ofloxacin, 2.0 and 32.0 microg/ml; levofloxacin, 1.0 and 16.0 microg/ml; sparfl ... | 1997 | 9210669 |
| sequence analysis and enzyme kinetics of the l2 serine beta-lactamase from stenotrophomonas maltophilia. | the l2 serine active-site beta-lactamase from stenotrophomonas maltophilia has been classified as a clavulanic acid-sensitive cephalosporinase. the gene encoding this enzyme from s. maltophilia 1275 iid has been cloned on a 3.3-kb fragment into pk18 under the control of a ptac promoter to generate recombinant plasmid pub5840; when expressed in escherichia coli, this gene confers resistance to cephalosporins and penicillins. sequence analysis has revealed an open reading frame (orf) of 909 bp wit ... | 1997 | 9210666 |
| aztreonam/clavulanic acid in the treatment of serious infections caused by stenotrophomonas maltophilia in neutropenic patients: case reports. | two seriously neutropenic patients (a 23-year-old man with a promyelocytic acute myeloid leukemia [aml-m3] and a 77-year old male with an immature acute myeloid leukemia [aml-m1] diagnosis) with severe infections caused by stenotrophomonas maltophilia were treated with aztreonam/clavulanic acid (2:1) combination. in the first patient the infection was caused by a multiresistant strain and in the second, by a strain with poor response to trimethoprim-sulfamethoxazole and other antimicrobial agent ... | 1997 | 9210009 |
| stenotrophomonas maltophilia meningitis. report of two cases and review of the literature. | the authors report two cases of meningitis caused by stenotrophomonas maltophilia in cancer patients following placement of an ommaya reservoir for treatment of meningeal carcinomatosis. in addition, they review eight other cases of s. maltophilia that have been reported to date. stenotrophomonas maltophilia meningitis is often associated with neurosurgical procedures; however, spontaneous infection may also occur, mainly in neonates. the disease's clinical presentation is similar to that of oth ... | 1997 | 9202275 |
| comparison of treatment with imipenem vs. ceftazidime as a predisposing factor for nosocomial acquisition of stenotrophomonas maltophilia: a historical cohort study. | imipenem is considered to confer greater risk for the acquisition of stenotrophomonas maltophilia than are other beta-lactam antibiotics. we conducted a historical cohort study to directly compare the risks of s. maltophilia acquisition in patients treated with imipenem vs. ceftazidime during a 2-year period; 843 hospitalizations of 759 patients treated with ceftazidime (465 hospitalizations), imipenem (294), or both agents (84) were included. acquisition, as measured by clinical detection, occu ... | 1997 | 9195070 |
| trimethoprim/sulfamethoxazole-induced hypoglycemia in a patient with acute renal failure. | to report a case of trimethoprim/sulfamethoxazole (tmp/smx)-induced hypoglycemia in a patient with acute renal failure. | 1997 | 9184713 |
| in-vitro microbiological assessment of a new penem, men 10700. | the in-vitro antibacterial activity of men 10700, a novel penem, has been compared with that of ritipenem, ciprofloxacin, amikacin, cefotaxime and co-amoxiclav against 539 strains taken from 17 genera. men 10700 was most active against staphylococci and streptococci (mic90 < 0.5 mg/l), slightly less active against escherichia coli, klebsiella pneumoniae, enterobacter spp., citrobacter spp., moraxella catarrhalis and peptostreptococci (mic90 0.5-2 mg/l), moderately active against enterococcus fae ... | 1997 | 9184355 |
| fatal pulmonary hemorrhage in patients with acute leukemia and fulminant pneumonia caused by stenotrophomonas maltophilia. | pulmonary hemorrhage is a rare cause of death in patients with acute leukemia. within a 3-month period we observed three such cases, all of which were associated with the gram-negative opportunistic pathogen stenotrophomonas maltophilia. since fatal lung bleeding had previously not been observed in conjunction with this organism, we collected the data from all patients with documented s. maltophilia infections or colonizations of the past year and analyzed the risk factors for a lethal outcome. ... | 1997 | 9174542 |
| comparison of axenic and monoxenic media for isolation of acanthamoeba. | acanthamoeba is a genus of ubiquitous, free-living amebae that can be difficult to isolate by standard microbiologic techniques. we retrospectively reviewed the laboratory records of patients with ocular acanthamoebic infection for the period from january 1973 to june 1996 and found that acanthamoeba isolates were recovered from 73, 71, and 70% of clinical specimens inoculated onto buffered charcoal-yeast extract agar (bcye), nonnutrient agar with live or dead escherichia coli, and tryptic soy a ... | 1997 | 9157153 |
| risk factors associated with isolation of stenotrophomonas (xanthomonas) maltophilia in clinical specimens. | to determine risk factors for patients whose cultures grew stenotrophomonas maltophilia. | 1997 | 9154473 |
| multiple antibiotic resistance in stenotrophomonas maltophilia. | a cryptic multidrug resistance (mdr) system in stenotrophomonas maltophilia, the expression of which is selectable by tetracycline, is described. tetracycline resistance was the consequence of active efflux of the antibiotic, and it was associated with resistance to quinolones and chloramphenicol, but not to aminoglycosides or beta-lactam antibiotics. mdr is linked to the expression of an outer membrane protein (omp54) both in a model system and in multidrug-resistant clinical isolates. | 1997 | 9145884 |
| antibacterial activity of bms-180680, a new catechol-containing monobactam. | the in vitro activities of a new catechol-containing monobactam, bms-180680 (sq 84,100), were compared to those of aztreonam, ceftazidime, imipenem, piperacillin-tazobactam, ciprofloxacin, amikacin, and trimethoprim-sulfamethoxazole. bms-180680 was often the most active compound against many species of the family enterobacteriaceae, with mics at which 90% of the isolates were inhibited (mic90s) of < or = 0.5 microg/ml for escherichia coli, klebsiella spp., citrobacter diversus, enterobacter aero ... | 1997 | 9145861 |
| the activity of the methylpiperazinyl fluoroquinolone cg 5501: a comparison with other fluoroquinolones. | the in-vitro activity of cg 5501 against a wide range of recent clinical isolates was compared with that of three fluoroquinolones. cg 5501 inhibited 90% of the species of the family enterobacteriaceae at 0.5 mg/l or less, exceptions being enterobacter spp. (mic90 2 mg/l) and serratia spp. (mic90 4 mg/l). ninety per cent of pseudomonas aeruginosa, stenotrophomonas maltophilia and acinetobacter spp. were inhibited by 16, 4 and 1 mg/l respectively. cg 5501 had high activity against gram-positive c ... | 1997 | 9145816 |
| different effects of zinc ions on in vitro susceptibilities of stenotrophomonas maltophilia to imipenem and meropenem. | 1996 | 9124868 | |
| stenotrophomonas maltophilia: emergence of multidrug-resistant strains during therapy and in an in vitro pharmacodynamic chamber model. | emergence of stenotrophomonas maltophilia as a nosocomial pathogen is becoming increasingly apparent. pleiotropic resistance characterizes s. maltophilia. furthermore, a slow growth rate and an increased mutation rate generate discordance between in vitro susceptibility testing and clinical outcome. despite original susceptibility, drug-resistant strains of s. maltophilia are often recovered from patients receiving beta-lactams, quinolones, or aminoglycosides. given the disparity among various i ... | 1996 | 9124855 |
| etiology of bacteraemia in patients with various malignancies: is there association between certain antineoplastic drugs and microorganism? | the authors studied a relationship between particular bacterial or fungal organisms isolated from blood cultures and type of malignancy and antineoplastic drugs in 237 cancer patients. sixty four had acute myelogenous leukemia (aml), 43 non-hodgkin's lymphoma (nhl) and 140 solid tumors (st). all patients had at least one positive blood cultures for one or more microorganism drawn during 1-10 days after cytotoxic chemotherapy, viridans streptococcal bacteremia was more frequently observed in pati ... | 1996 | 9117432 |
| antibacterial activities of grepafloxacin, ciprofloxacin, ofloxacin and fleroxacin. | grepafloxacin (opc-17116) and three other fluoroquinolones were tested against 461 bacterial isolates representing 44 species. grepafloxacin was superior to ciprofloxacin, ofloxacin and fleroxacin in its activity against the gram-positive cocci, including staphylococci, pneumococci and hemolytic streptococci. attempts to select grepafloxacin-resistant mutants from a methicillin-resistant staphylococcus aureus strain were unsuccessful, although ciprofloxacin readily selected quinolone-resistant m ... | 1997 | 9106012 |
| comparison of 16s ribosomal dna sequences of all xanthomonas species. | the phylogenetic relationships of all validly described species of the genus xanthomonas and the type strain of stenotrophomonas maltophilia were analyzed by sequencing and comparing 16s ribosomal dnas (rdnas). the two genera exhibited a mean sequence similarity value of 96.6%, corresponding to differences at 50 nucleotide positions on average. the species of the genus xanthomonas exhibited relatively high levels of overall sequence similarity; the mean similarity value was 98.2%, which correspo ... | 1997 | 9103617 |
| structure of the o2 antigen of stenotrophomonas (xanthomonas or pseudomonas) maltophilia. | an o antigenic polymer containing l-rhamnose, d-mannose, and l-xylose was isolated from the lipopolysaccharide present in the reference strain for stenotrophomonas (xanthomonas or pseudomonas) maltophilia serogroup o2, by mild acid hydrolysis and gel-permeation chromatography. by means of nmr spectroscopy and chemical degradations, the polysaccharide was found to be based on a branched trisaccharide repeating-unit of the structure shown. [formula: see text]. | 1997 | 9090815 |
| sensitivity of aeromonas hydrophila carbapenemase to delta3-cephems: comparative study with other metallo-beta-lactamases. | ceftriaxone and ceftriaxone s-oxide behaved as inactivators against the metallo-beta-lactamase of aeromonas hydrophila ae036 and as substrates for the zinc beta-lactamase produced by bacillus cereus (569/h/9) and stenotrophomonas maltophilia ula 511. moreover, ro 09-1428, a catechol-cephalosporin, was not recognized by the a. hydrophila enzyme. panipenem, cephalosporin c, cephalosporin c-gamma-lactone, and loracarbef were substrates for the three studied beta-lactamases. | 1997 | 9087509 |
| stenotrophomonas (xanthomonas) maltophilia: a multidrug-resistant nosocomial pathogen. | stenotrophomonas (xanthomonas) maltophilia is emerging as a multidrug-resistant nosocomial pathogen. in general, the organism is opportunistic, colonizing or infecting patients with predisposing risk factors such intensive care unit residence, malignancy, mechanical ventilation, and previous antibiotic exposure. it can cause a variety of infections depending on underlying patient-specific medical conditions. it is often part of multimicrobial infections, and determining its role as a pathogen is ... | 1997 | 9085321 |
| effect of bacteria on survival and growth of acanthamoeba castellanii. | the growth and survival of acanthamoeba castellanii in the presence of gram-negative bacteria such as pseudomonas aeruginosa, escherichia coli, serratia marcescens, and stenotrophomonas maltophilia varied with the densities and species of bacteria. all species of bacteria suspended in a buffered saline at densities of 10(5) to 10(6)/ml supported the growth and survival of 10(6)/ml trophozoites of acanthamoeba castellanii in a buffered saline solution. at densities of bacteria to amoebae of 100:1 ... | 1997 | 9058539 |
| in-vitro pharmacodynamic studies of piperacillin/tazobactam with gentamicin and ciprofloxacin. | six isolates each of enterococcus faecium, staphylococcus aureus, staphylococcus epidermidis, streptococcus pyogenes, stenotrophomonas maltophilia, pseudomonas aeruginosa, citrobacter spp., serratia spp., acinetobacter spp. and enterobacter spp. (total 60 strains) were studied against the combination of piperacillin/tazobactam plus gentamicin or ciprofloxacin at physiological concentrations by the microtitre chequerboard method incorporating simultaneous time-kill curves. tazobactam was fixed at ... | 1997 | 9044028 |
| the in-vitro activity of faropenem, a novel oral penem. | the in-vitro activity of faropenem, a novel oral penem, was studied in comparison with other beta-lactam antimicrobials against 711 recent clinical isolates including gram-negative, gram-positive and anaerobic bacteria. mic data showed that faropenem was active against most members of the enterobacteriaceae (mics < or = 4 mg/l), with reduced activity against serratia spp. (mic90 = 32 mg/l). in common with its comparators, faropenem had weak activity against pseudomonas aeruginosa and stenotropho ... | 1997 | 9044026 |
| effect of temperature on aminoglycoside binding sites in stenotrophomonas maltophilia. | in this study we used strains of stenotrophomonas maltophilia grown at 30 degrees c and 37 degrees c to investigate the role of lipopolysaccharide (lps) in temperature-dependent variations in sensitivity (tdvs) to gentamicin. tdvs was scored as 'good' if a four-fold or greater difference in minimum inhibitory concentration (mic) was found between the two incubation temperatures (good tdvs strains; n = 23), and otherwise as 'poor' (poor tdvs strains; n = 15). phosphate content of isolated lps in ... | 1997 | 9044023 |
| production and characterization of monoclonal antibodies specific for the lipopolysaccharide of escherichia coli o157. | identification of the o157 antigen is an essential part of the detection of escherichia coli o157:h7, which is recognized as a major etiologic agent of hemorrhagic colitis. however, polyclonal antibodies produced against e. coli o157:h7 lipopolysaccharide (lps) may react with several other bacteria including brucella abortus, brucella melitensis, yersinia enterocolitica o9, escherichia hermannii, and stenotrophomonas maltophilia. we produced eight monoclonal antibodies (mabs) specific for the lp ... | 1997 | 9041412 |
| identification of burkholderia cepacia isolates from patients with cystic fibrosis and use of a simple new selective medium. | we evaluated 819 isolates referred to us as "burkholderia cepacia" from cystic fibrosis (cf) clinics and research laboratories from five countries; 28 (3.4%) were not b. cepacia. a further 12 (1.5%) organisms appeared to be other burkholderia species, but identification could not be confirmed by conventional means. the most prevalently misidentified organisms were stenotrophomonas maltophilia, alcaligenes xylosoxidans, and comamonas acidovorans. many of these organisms grew on oxidation-fermenta ... | 1997 | 9041399 |
| [determination of serum aminoglycoside and vancomycin concentrations by the microbiological method in the presence of other antimicrobials]. | the determination of serum concentrations of antimicrobials with a narrow therapeutic range by microbiological method requires some modifications when the patient is under combined antimicrobial therapy. the methodological conditions for the appraisal of aminoglycosides and vancomycin in the presence of other drugs were evaluated by using strains with selective sensitivity to the antimicrobial to be tested or by the adding crude extracts of beta-lactamases for the inactivation of the beta-lactam ... | 1996 | 9026822 |
| polymerase chain reaction for the detection of pseudomonas aeruginosa, stenotrophomonas maltophilia and burkholderia cepacia in sputum of patients with cystic fibrosis. | occurrence of pseudomonas aeruginosa, stenotrophomonas (xanthomonas) maltophilia and burkholderia (pseudomonas) cepacia in sputum of cystic fibrosis (cf) patients was demonstrated with a simple and rapid polymerase chain reaction (pcr) technique. the pcr was performed with a set of three primer pairs based on 16s rrna sequences after sputum preparation with dithiothreitol and naoh lysis. all three pathogens could be individually detected by the use of this technique. to prevent carry-over contam ... | 1996 | 9025076 |
| in vitro activity and spectrum of ly333328, a novel glycopeptide derivative. | reference methods were used to determine the potency of ly333328, a semisynthetic glycopeptide derivative with a key n-alkylation substitution, against 833 strains (393 gram-positive strains and representative gram-negative bacilli) with various defined resistance mechanisms. the mics at which 90% of the isolates are inhibited (mic90s) (in micrograms per milliliter) of ly333328 and the percentages of strains at < or = 8 micrograms/ml were as follows: for oxacillin-susceptible staphylococcus aure ... | 1997 | 9021216 |
| activity of trimethoprim/sulfamethoxazole plus polymyxin b against multiresistant stenotrophomonas maltophilia. | the inhibitory activity of eight antibiotics and the inhibitory and bactericidal activities of combinations of trimethoprim/sulfamethoxazole (tmp/smx) plus three fixed concentrations of polymyxin b (0.01 microgram/ml, 0.1 microgram/ml and 0.5 microgram/ml) against 30 multi-resistant strains of stenotrophomonas maltophilia were tested. polymyxin b at 0.01 microgram/ml modified the inhibitory activity of tmp/smx against only 40% of strains. at 0.1 microgram/ml and 0.5 microgram/ml, polymyxin b enh ... | 1996 | 8997563 |
| molecular epidemiology of burkholderia cepacia, stenotrophomonas maltophilia, and alcaligenes xylosoxidans in a cystic fibrosis center. | burkholderia cepacia, stenotrophomonas maltophilia, and alcaligenes xylosoxidans have been isolated with increasing frequency from the sputum of patients with cystic fibrosis in a pediatric hospital. in 1994-95, 27 of 120 patients were persistently colonized, 17 with burkholderia cepacia, eight with alcaligenes xylosoxidans, and five with stenotrophomonas maltophilia. genotyping of 220 clinical isolates revealed that most of the burkholderia cepacia strains were clonally related, suggesting eith ... | 1996 | 8997562 |
| stenotrophomonas africana sp. nov., an opportunistic human pathogen in africa. | a gram-negative bacterium was isolated from a cerebrospinal fluid sample from an hiv-seropositive rwandan refugee with primary meningoencephalitis. this marseille-goma sample b isolate, strain mgbt (t = type strain), was found to exhibit evolutionary homology with stenotrophomonas maltophilia, as determined by a 16s rrna gene sequence analysis, and this finding was reflected by similar phenotypic traits. mgbt could, however, be distinguished from the s. maltophilia type strain by using a number ... | 1997 | 8995819 |
| maltophilin: a new antifungal compound produced by stenotrophomonas maltophilia r3089. | strains of stenotrophomonas maltophilia r3089, isolated from the rhizosphere of rape plants (brassica napus l.), produced a novel antifungal compound, named maltophilin, which inhibited the growth of various saprophytic, human-pathogenic and phytopathogenic fungi but was inactive against gram-positive and gram-negative bacteria. maltophilin is a novel macrocyclic lactam antibiotic with a molecular mass of 510 mu. the compound was isolated from the culture filtrate by ethyl acetate extraction and ... | 1996 | 8982338 |
| inhibition of metallo-beta-lactamases by a series of mercaptoacetic acid thiol ester derivatives. | a series of mercaptoacetic acid thiol esters have been identified as metallo-beta-lactamase inhibitors. electrospray mass spectrometry (esms) has shown that irreversible inhibition of the bacillus cereus ii metallo-beta-lactamase by sb214751, sb214752, and sb213079 was concomitant with a 90-da increase in mass of the enzyme. tryptic digestion of the b. cereus ii inhibited with sb214751 illustrated that the peptide fragment, containing the only cysteine of the enzyme, had undergone a mass increme ... | 1997 | 8980769 |
| in vitro activity of bay 12-8039, a new fluoroquinolone. | the in vitro activity of bay 12-8039, a new fluoroquinolone, was studied in comparison with those of ciprofloxacin, trovafloxacin (cp 99,219), cefpodoxime, and amoxicillin-clavulanate against gram-negative, gram-positive, and anaerobic bacteria. its activity against mycobacteria and chlamydia was also investigated. bay 12-8039 was active against members of the family enterobacteriaceae (mic at which 90% of strains tested were inhibited [mic90s] < or = 1 microgram/ml, except for serratia spp. mic ... | 1997 | 8980763 |
| structure of the o20 antigen of stenotrophomonas (xanthomonas or pseudomonas) maltophilia. | the o-antigen polymer recovered from the reference strain for stenotrophomonas (xanthomonas or pseudomonas) maltophilia serogroup o20, by mild acid hydrolysis of the lipopolysaccharide, was found to contain d-rhamnose and d-mannose. by means of chemical degradations and nmr studies, the repeating-unit of the polymer was deduced to be a linear tetrasaccharide with the structure shown. -->2)-alpha-d-manp-(1-->3)-beta-d-rhap-(1-->2)-alpha-d-rh ap-(1-->2)-alpha-d- rhap-(1-->. | 1996 | 8962488 |
| bacteremia and fungemia occurring during antimicrobial prophylaxis with ofloxacin in cancer patients: risk factors, etiology and outcome. | the authors analyzed 27 breakthrough bacteremias occurring during ofloxacin prophylaxis in afebrile neutropenia over 7 years in 9989 admissions and 979 bacteremic and fungemic episodes in a national cancer center in bratislava, slovak republic. the most frequently isolated organisms in breakthrough bacteremias were gram-positive (71.3%), mainly coagulase-negative staphylococci (41.3%), enterococci (9.2%) and corynebacteria (9.2%), followed by gram-negative rods-pseudomonas aeruginosa (13.2%) and ... | 1996 | 8957720 |
| endocarditis caused by stenotrophomonas maltophilia: case report and review. | stenotrophomonas (xanthomonas) maltophilia is a rare cause of endocarditis. the extensive resistance of this organism to several antibiotics leaves few options for antimicrobial therapy. in vitro synergism of the combination of trimethoprim-sulfamethoxazole (tmp-smz) and ticarcillin/clavulanic acid (tic/ca) has been demonstrated. to our knowledge, we report the first case of ventriculoatrial cerebrospinal fluid shunt-associated endocarditis due to s. maltophilia. the patient was cured with combi ... | 1996 | 8953069 |
| investigation of a multiyear multiple critical care unit outbreak due to relatively drug-sensitive acinetobacter baumannii: risk factors and attributable mortality. | from 1990 to 1993, an outbreak of respiratory acinetobacter baumannii infection occurred in five intensive care units (icus) of a tertiary care center. a. baumannii was subsequently isolated from disinfected temperature probes and ventilator circuits. pulsed-field gel electrophoresis suggested that a single strain accounted for 93% of patient isolates and 88% of environmental isolates. univariate risk factors for a. baumannii acquisition were tracheostomy (p < .01), ventilation >3 days (p < .01) ... | 1996 | 8940219 |
| [simultaneous isolation of mrsa and pseudomonas aeruginosa using a novel selective and differential pmac agar]. | pmac agar, a novel, selective and differential medium has been developed and was subjected for evaluation of its selective and differential capability of methicillin resistant staphylococcus aureus (mrsa) and pseudomonas aeruginosa from other bacteria such as bacillus, micrococcus, gram-negative bacteria and drug resistant ones. growth of mrsa and p. aeruginosa on pmac agar was facilitated and their colonies were easily differentiated. colonies of mrsa after 24 approximately 48 h incubation at 3 ... | 1996 | 8921677 |
| inhibition of growth of fungi pathogenic to man by stenotrophomonas maltophilia. | ten strains of stenotrophomonas maltophilia were tested by a cross-streaking method for in-vitro inhibition of 10 strains of fungi known to infect man; these were candida krusei, c. keyfr, c. guillermondii, c. tropicalis, c. lusitaniae, c. parapsilosis, c. pseudotropicalis, c. albicans, c. glabrata and aspergillus fumigatus. significant inhibition of fungal growth was observed with all 10 strains of s. maltophilia, but not with escherichia coli nctc 10418, staphylococcus aureus nctc 6571 and hae ... | 1996 | 8918956 |
| home-use nebulizers: a potential primary source of burkholderia cepacia and other colistin-resistant, gram-negative bacteria in patients with cystic fibrosis. | inhalation of aerosols contaminated with gram-negative bacteria generated from home-use nebulizers used by cystic fibrosis (cf) patients may be a primary route for bacterial colonization of the lung. burkholderia cepacia was isolated from 3 of [corrected] 35 home-use nebulizers, and stenotrophomonas maltophilia was isolated from 4 of 35 home-use nebulizers. sputum cultures for two patients whose nebulizers were contaminated with b. cepacia did not yield the organism. however, dna macrorestrictio ... | 1996 | 8904419 |
| use of random amplified polymorphic dna for epidemiological typing of stenotrophomonas maltophilia. | we used the technique of random amplification of polymorphic dna (rapd) to type 130 isolates of stenotrophomonas (xanthomonas) maltophilia, using four arbitrary short primers. of the 130 isolates, 51 were from the hospital environment, 48 from clinical specimens and 31 were geographically diverse environmental isolates. dna amplification with the four sets of primers generated 112 rapd patterns that differed by two or more bands in one of the four primers. sixteen pairs of isolates were of the s ... | 1996 | 8904371 |
| use of sterile compared with tap water in gastrointestinal endoscopic procedures. | because of the concern for infection risk, use of sterile water has been recommended in the water bottle for endoscopic equipment, although studies evaluating prevalence of contamination of the water bottle with clinical outcomes have not been performed. | 1996 | 8902118 |
| stenotrophomonas maltophilia bacteraemia in cancer patients: report on 31 cases. | 1996 | 8880554 | |
| bacteremia due to glucose non-fermenting gram-negative bacilli in patients with hematological neoplasias and solid tumors. | twenty-six patients with hematological or solid tumors who developed bacteremia caused by stenotrophomonas maltophilia (n = 10), pseudomonas putida (n = 6), sphingomonas paucimobilis complex (n = 4) or alcaligenes xylosoxidans (n = 6) in the period between 1993 and 1995 were studied. seventeen patients were neutropenic during the infection, and 13 were undergoing bone marrow or peripheral blood stem cell transplantation. twenty-three patients had catheter-related infections; only 3 of the 26 pat ... | 1996 | 8874083 |
| a new selective differential medium for isolation of stenotrophomonas maltophilia. | a new selective differential medium for the isolation of stenotrophomonas (formerly xanthomonas) maltophilia was developed. the medium, via agar, contained vancomycin, imipenem, and amphotericin b as selective agents and incorporated a mannitol/bromothymol blue indicator system. compared with xanthomonas maltophilia selective medium (xmsm), via agar was less inhibitory to stenotrophomonas maltophilia and was more selective than xmsm in preventing the growth of unwanted bacteria from contaminated ... | 1996 | 8874082 |
| clinical features of stenotrophomonas maltophilia pneumonia in immunocompromised patients. | between january 1988 and december 1992, 68 patients admitted to our department of internal medicine with haematological malignancies or solid tumours showed colonization of the respiratory tract with stenotrophomonas maltophilia. to characterize the significance of respiratory tract colonization by s. maltophilia, we retrospectively reviewed the medical records of the 68 patients colonized with this organism. twenty-nine of these 68 patients developed pneumonia, with s. maltophilia being implica ... | 1996 | 8857324 |
| mechanisms of bacterial antibiotic resistance. | infectious complications are major contributing factors to morbidity and mortality in the icu setting. organisms frequently encountered in the icu include pseudomonas aeruginosa, staphylococcus aureus, haemophilus influenzae (particularly in trauma victims), enterococci, klebsiella pneumoniae, enterobacter spp., acinetobacter baumanii, escherichia coli, and stenotrophomonas (xanthomonas) maltophilia. antibiotics have played a major role in the treatment of infections caused by such bacterial pat ... | 1996 | 8856749 |
| bacteremia due to stenotrophomonas (xanthomonas) maltophilia: a prospective, multicenter study of 91 episodes. | we identified 91 cases of bacteremia due to stenotrophomonas (xanthomonas) maltophilia in a prospective, multicenter observational study. the patients were highly compromised; the majority had an underlying malignancy, had received immunosuppressive therapy, and had indwelling venous catheters. although 94% of patients received an antimicrobial agent to which the blood isolate was susceptible, the mortality among these patients 14 days after the onset of bacteremia was 21%. mortality was signifi ... | 1996 | 8852971 |
| susceptibilities of non-pseudomonas aeruginosa gram-negative nonfermentative rods to ciprofloxacin, ofloxacin, levofloxacin, d-ofloxacin, sparfloxacin, ceftazidime, piperacillin, piperacillin-tazobactam, trimethoprim-sulfamethoxazole, and imipenem. | agar dilution mics of 10 agents against 410 non-pseudomonas aeruginosa gram-negative nonfermentative rods were determined. mics at which 50 and 90% of the isolates were inhibited, respectively, were as follows (in micrograms per milliliter): sparfloxacin, 0.5 and 8.0; levofloxacin, 1.0 and 8.0; ciprofloxacin, 2.0 and 32.0; ofloxacin, 2.0 and 32.0; d-ofloxacin, 32.0 and > 64.0; ceftazidime, 8.0 and 64.0; piperacillin with or without tazobactam, 16.0 and > 64.0; trimethoprim-sulfamethoxazole, 0.5 ... | 1996 | 8851609 |
| [utility of pyrrolidonyl-arylamidase detection for typing enterobacteriaceae and non-fermenting gram-negative bacteria]. | detection of pyrrolidonyl-aryl-amidase activity (pyr) is an important tool to identify gram-positive cocci, such as staphylococci, enterococci, streptococci, and other related genera. however, only few studies evaluating its usefulness with gram-negative rods have been published. thus, a prospective study including 542 and 215 unique clinical isolates of enterobacteriaceae and non-fermentative gram-negative rods, respectively, was undertaken. strains were identified by conventional methods. pyr ... | 1995 | 8850133 |
| septic prepatellar bursitis caused by stenotrophomonas (xanthomonas) maltophilia. | 1996 | 8838214 | |
| survey of antimicrobial activity of four commonly used third generation cephalosporins tested against recent bacterial isolates from ten american medical centers, and assessment of disk diffusion test performance. ast surveillance group. | over 2,000 clinical isolates from ten american medical centers were tested for susceptibility to cefotaxine, ceftriaxone, ceftizoxime, and ceftazidime by both broth microdilution and disk diffusion methods. typically resistant (e.g. enterococci) and highly susceptible (e.g. streptococci) isolates showed no change in susceptibility patterns compared to previous surveys. pseudomonas aeruginosa and stenotrophomonas maltophilia exhibited significant decreases in susceptibility to these cephalosporin ... | 1996 | 8831036 |
| adhesion of the positively charged bacterium stenotrophomonas (xanthomonas) maltophilia 70401 to glass and teflon. | medical implants are often colonized by bacteria which may cause severe infections. the initial step in the colonization, the adhesion of bacteria to the artificial solid surface, is governed mainly by long-range van der waals and electrostatic interactions between the solid surface and the bacterial cell. while van der waals forces are generally attractive, the usually negative charge of bacteria and solid surfaces leads to electrostatic repulsion. we report here on the adhesion of a clinical i ... | 1996 | 8808938 |
| role of anti-pseudomonal antibiotics in the emergence of stenotrophomonas maltophilia in cystic fibrosis patients. | a retrospective case-control study of 12 patients positive for stenotrophomonas maltophilia and 24 age-sex-matched controls revealed that in the year prior to initial isolation, colonised patients spent more days in hospital and received more days of oral ciprofloxacin, intravenous anti-pseudomonal antibiotics, and nebulised aminoglycosides. they were also more likely to have grown pseudomonas aeruginosa at some time in the past, despite there being no difference in current chronic infection wit ... | 1996 | 8793400 |
| [antibacterial activity of sulopenem, a new parenteral penem antibiotic]. | sulopenem, a new penem antibiotic, was compared with other antibiotics with regard to in vitro antibacterial and bactericidal activities, stabilization against beta-lactamases, and effect on the release of lipopolysaccharide from gram-negative bacteria. the results are summarized as follows. 1. sulopenem showed more potent activities than other antibiotics against both gram-positive and gram-negative bacteria except pseudomonas aeruginosa. 2. sulopenem showed potent bactericidal activities (mic/ ... | 1996 | 8786625 |
| [molecular typing by pulsed field gel electrophoresis of stenotrophomonas maltophilia isolated in a department of hematology]. | stenotrophomonas maltophilia is an important nosocomial pathogen. the increased isolates of s. maltophilia among hematology unit patients led to an epidemiological survey. over 26 months, 24 strains isolated from 23 patients and an environmental isolate from blood pressure armband have been identified. the isolated were first analysed by the use of phenotypical markers: biotype, antibiotic susceptibility, but the minor differences observed justified a genotypic analysis. pulsed field gel electro ... | 1996 | 8758490 |
| [kinetics of bactericidal activity of cefepime and cefpirome alone or combined with gentamicin, amikacin or ciprofloxacin against acinetobacter baumannii, stenotrophomonas maltophilia and enterobacter cloacae hyperproductive in cephalosporinase]. | nosocomial infections encountered in intensive care units are frequently due to gram negative bacilli among which stenotrophomonas maltophilia, acinetobacter sp., and enterobacter sp. the aim of the present study was to evaluate the in vitro bactericidal activity of the new broad spectrum cephalosporins cefepime (fep) and cefpirome (cpo) alone or in combination with amikacin (akn), gentamicin (gtn) or ciprofloxacin (cip) against acinetobacter baumannii, stenotrophomonas maltophilia and enterobac ... | 1996 | 8758478 |
| evaluation of the dna fingerprinting method aflp as an new tool in bacterial taxonomy. | we investigated the usefulness of a novel dna fingerprinting technique, aflp, which is based on the selective amplification of genomic restriction fragments by pcr, to differentiate bacterial strains at the subgeneric level. in totals, 147 bacterial strains were subjected to aflp fingerprinting: 36 xanthomonas strains, including 23 pathovars of xanthomonas axonopodis and six pathovars of xanthomonas vasicola, one strain of stenotrophomonas, 90 genotypically characterized strains comprising all 1 ... | 1996 | 8757752 |
| a reappraisal of the diversity and class distribution of aspartate transcarbamoylases in gram-negative bacteria. | recently, the subunit composition of class a aspartate transcarbamoylases (atcases) in fluorescent pseudomonads has been clarified. we present evidence that distribution of this type of atcase may be more widespread than at first suspected. bacterial atcases exist in three forms: class a (molecular mass approximately 450-500 kda); class b, typified by escherichia coli atcase (approximately 300 kda); and class c, typified by bacillus subtilis atcase (approximately 100 kda). using gradient gel ele ... | 1996 | 8757751 |
| in vitro activities of quinolones, beta-lactams, tobramycin, and trimethoprim-sulfamethoxazole against nonfermentative gram-negative bacilli. | from 1991 to 1995, 8,975 nonfermentative gram-negative bacilli were isolated from patients at the ohio state university medical center: 71% pseudomonas aeruginosa, 14% stenotrophomonas maltophilia, 7.6% acinetobacter baumannii, and < 2% each of 25 other species. the mics of trovafloxacin (cp-99,219), ciprofloxacin, ofloxacin, ampicillin-sulbactam, piperacillin, piperacillin-tazobactam, ceftazidime, cefoperazone, ceftriaxone, imipenem, tobramycin, and trimethoprim-sulfamethoxazole (tmp-smz) were ... | 1996 | 8726011 |
| in vitro activity of the tricyclic beta-lactam gv104326. | gv104326 is a novel tricyclic beta-lactam (a trinem or, formerly, tribactam). the in vitro activity of gv104326 was compared with those of cefuroxime, cefixime, amoxicillin, amoxicillin-clavulanic acid, cefpirome, and ciprofloxacin. gv104326 had in vitro activity generally similar to that of cefixime against members of the family enterobacteriaceae (mic at which 90% of the isolates are inhibited [mic90], < or = 2 micrograms/ml), with cefuroxime and amoxicillin-clavulanic acid being 8- to 32-fold ... | 1996 | 8723475 |
| temperature-dependent aminoglycoside resistance in stenotrophomonas (xanthomonas) maltophilia; alterations in protein and lipopolysaccharide with growth temperature. | clinical strains of stenotrophomonas (xanthomonas) maltophilia often show large, growth temperature-dependent, variations in their susceptibility (tdvs) to aminoglycoside antibiotics. strains showing more than a fourfold increase in susceptibility between 30 degrees and 37 degrees c (tdvs+ strains; n = 23) were contrasted with those showing lesser variation (tdvs- strains; n = 15) in studies of growth temperature-dependent variation in protein and cell-wall lipopolysaccharide (lps) electrophores ... | 1996 | 8722532 |
| structure of the o3 antigen of stenotrophomonas (xanthomonas or pseudomonas) maltophilia. | the o antigen isolated from the lipopolysaccharide of a strain of stenotrophomonas (xanthomonas or pseudomonas) maltophilia serogroup o3 was found to contain 4-acetamido-4,6-dideoxy-d-galactose, d-fucose, and n-acetyl-d-glucosamine. by means of chemical degradations and nmr spectroscopy the repeating unit of the o-specific polymer was determined to be a branched trisaccharide repeating-unit of the structure shown. | 1996 | 8721742 |
| sensitivity of l-2 type beta-lactamases from stenotrophomonas maltophilia to serine active site beta-lactamase inhibitors. | 1996 | 8707755 | |
| stenotrophomonas maltophilia: an unusual cause of biliary sepsis. | we report three cases of cholangitis caused by stenotrophomonas maltophilia and review two other cases reported in the literature. all five episodes occurred in patients with hepatobiliary malignancy complicated by biliary tract obstruction. all five episodes occurred in patients with hepatobiliary malignancy complicated by biliary tract obstruction. all patients had undergone biliary tract instrumentation. before infection developed, four of the five patients had received therapy with antibioti ... | 1995 | 8645796 |
| isepamicin (sch 21420, 1-n-hapa gentamicin b): microbiological characteristics including antimicrobial potency of spectrum of activity. | isepamicin (formerly sch 21420 or 1-n-hapa-gentamicin b) is a novel broad-spectrum aminoglycoside which possesses a high level of stability to aminoglycoside inactivating enzymes and low levels of toxicity to the kidney and inner ear. the only modifying enzymes capable of inactivating isepamicin are ant(4')-i (staphylococci), ant(4')-ii and aph(3')-vi, in addition to resistance mediated by permeability mutations. the spectrum of isepamicin is most similar to that of amikacin, another aminoglycos ... | 1995 | 8622113 |
| in vitro susceptibility of 124 xanthomonas maltophilia (stenotrophomonas maltophilia) isolates: comparison of the agar dilution method with the e-test and two agar diffusion methods. | the in vitro susceptibility of 124 xanthomonas maltophilia isolates was tested by four methods: agar dilution (reference method), e-test, a disk diffusion and a tablet diffusion method. trimethoprim-sulfamethoxazole had the highest activity against x. maltophilia, followed by a combination of aztreonam-clavulanic acid at different ratios, the ratio 1:1 being the most active with a susceptibility rate of 85% as compared to 2% for aztreonam alone. addition of the beta-lactamase inhibitor tazobacta ... | 1996 | 8619912 |
| antimicrobial activity of cs-940, a new trifluorinated quinolone. | the antimicrobial activity of cs-940, a new trifluorinated quinolone drug, was tested against 761 clinical isolates. cs-940 activity against members of the family enterobacteriaceae was most similar to that of ciprofloxacin and ofloxacin, with a large range of mics inhibiting 90% of isolates tested (mic90s) of 0.015 to 16 micrograms/ml (median mic90, 0.06 micrograms/ml). cs-940 had greater activity than ciprofloxacin or ofloxacin when they were tested against acinetobacter spp. (mic90s, 0.03 mic ... | 1995 | 8619590 |
| in vitro activities of antimicrobial combinations against stenotrophomonas (xanthomonas) maltophilia. | stenotrophomonas (xanthomonas) maltophilia is inherently resistant to multiple antimicrobial agents. in order to investigate the in vitro potential of combinations of antimicrobial agents, we obtained 230 epidemiologically unrelated clinical isolates from seven hospitals across canada and from northwestern memorial hospital in chicago. ticarcillin-clavulanate combined with ciprofloxacin or trimethoprim-sulfamethoxazole were assayed for synergy against 31 ticarcillin-resistant strains of s. malto ... | 1995 | 8619571 |
| stenotrophomonas (xanthomonas) maltophilia urinary tract infection. a disease that is usually severe and complicated. | stenotrophomonas (xanthomonas) maltophilia has emerged as a causative agent of serious nosocomial infections. however, well-documented cases of urinary tract infection with this organism have rarely been reported. | 1996 | 8607729 |
| transfer of ceftazidime and aztreonam resistance from nosocomial strains of xanthomonas (stenotrophomonas) maltophilia to a recipient strain of pseudomonas aeruginosa ml-1008. | 1995 | 8605913 | |
| stenotrophomonas maltophilia ocular infections. | to determine if the number of ocular infections associated with stenotrophomonas maltophilia is increasing, to identify predisposing factors, and to evaluate antimicrobial susceptibility. | 1996 | 8602781 |
| purification and characterization of a newly screened microbial peptide amidase. | a microbial peptide amidase was found in a limited screening and purified about 500-fold from stenotrophomonas maltophilia. the native enzyme has a molecular mass of 38 kda (gel filtration). the sequence of the first 16 amino acids was determined by edman degradation. the isoelectric point was found to be around 5.8. the peptide amidase exhibited a ph optimum of 6.0 and a temperature optimum of about 39-45 degrees c. the enzyme is stable in 50 mm tris/hcl, ph 7.5, at 30 degrees c, and the residu ... | 1995 | 8597540 |