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spleen cell responses in experimental murine toxocariasis.splenic responses of cba/j mice infected with 250 embryonated ova of the nematode, toxocara canis were characterized during the first month post-inoculation (p.i.). by the 6th day of infection, spleen to body weight ratios were over 3.5 times greater in infected mice than uninfected controls. this ratio peaked at 5.0 on day 14 and declined slightly by day 36 p.i. lymphocyte transformation studies were carried out using the t cell mitogens, con a and pha and the b mitogen, lps. the responses of i ...19846334150
immunodiagnosis of parasitic zoonoses: sensitivity and specificity of in vitro lymphocyte proliferative responsiveness using nematode antigens purified by affinity chromatography.the sensitivity of in vitro lymphocyte proliferative responsiveness using antigens purified by affinity chromatography, was greater than that of three serological tests and allowed the specific identification of dirofilaria immitis, toxocara canis, angiostrongylus cantonensis and ascaris lumbricoides in animals sensitized with parasite antigens, and the diagnosis of natural (d. immitis, t. canis and angiostrongylus cantonensis) and zoonotic nematode infections. lymphocytes remained viable in who ...19816168047
a collaborative study on larval excretory/secretory antigens of toxocara canis for the immunodiagnosis of human toxocariasis with elisa.two batches of excretory/secretory (e/s) antigens from second stage larvae of toxocara canis maintained in vitro were prepared independently in two different laboratories (zürich and basel) and analysed in order to obtain information for future efforts to standardize the enzyme-linked immunosorbent assay (elisa) used for the serodiagnosis of human toxocariasis. sds-page and "western-blotting" revealed at least 10 different antigenic components common to the two antigen preparations. however, dis ...19846084948
[toxocara canis of the eye]. 19676080326
human toxocara canis encephalopathy in a case of visceral larva migrans. 19676066953
incidence of toxocara canis and other helminth parasites of dogs in mexico city. 19676035723
anaphylactic and reagin-like antibody in rats infected with toxocara canis larvae. 19676017229
the prenatal migration of toxocara canis larvae and their relationship to infection in pregnant bitches and in pups. 19666006715
[localization in the brain of the guinea pig of 2nd stage larvae of toxocara canis (werner, 1782). electroencephalographic, parasitological and anatomo-histopathological documentation]. 19665991288
[clinical case with parasitological confirmation of migratory visceral larva caused by toxocara canis in colombia]. 19665990128
the migratory behaviour of the larvae of toxocara canis (werner 1782) in white mice. 19665980873
[the development of the canine ascarid toxocara canis (werner 1782) in the adequate and non-adequate host. experimental chemotherapeutic influencing of its larvae ("larva migrans visceralis") in the animal experiment (mouse)]. 19665974165
infection with adult toxocara canis. 19665940227
effect of toxocara canis infection on the ability of white rats to solve maze problems. 19665925491
[intraocular toxocara canis infestation]. 19655895724
[case of extreme eosinophilia in toxocara canis infestation]. 19655851202
toxocara canis infection in a jamaican child. 19695821281
immunological response of the hosts to toxocara canis (werner, 1782) infection. i. effect of superinfection on naturally infected puppies. 19685754272
experimental studies on toxascaris leonina. vi. experimental infection of mice, chickens and earthworms with toxascaris leonina, toxocara canis and toxocara cati. 19685750134
experimental toxocariasis. ii. toxocara canis in the mouse as a system for testing compounds of potential anthelmintic acitivity. 19685706751
experimental toxocariasis. i. some observations on the histopathology of the migration of toxocara canis larvae in the mouse. 19685706750
experimental studies on toxascaris leonina. iv. development of eggs of three ascarids, t. leonina, toxocara canis and toxocara cati, in dogs and cats. 19685692326
heterophile antibodies in toxocara canis infection in rabbits. 19685669563
age resistance to toxocara canis in ascarid-free dogs. 19715567417
hypersensitivity to some nematode antigens.immediate and delayed skin reactions to antigens derived from ascaris suum, necator americanus, and toxocara canis are described in three subjects and related to eosinophil counts and serum ige levels. one, who had laboratory contact with ascarides but no known infection, gave positive immediate reactions to all three antigens. another, following repeated experimental infection with necator, gave positive immediate reactions to all three antigens and a delayed reaction to necator alone. the thir ...19715541233
toxoplasmal and toxocaral infections: a clinical investigation into their relationship.an investigation was carried out to determine whether a relationship existed between infections with toxoplasma gondii and toxocara canis. antibodies were sought by the toxoplasma dye test and the toxocara skin sensitivity test. sixty-seven patients were examined in the united kingdom; 38 had positive toxoplasma dye tests, two of these being toxocara-positive; and 29 had negative dye tests, six of them being toxocara-positive. from the total of eight toxocarapositive patients antibodies to toxop ...19705475821
resistance of mice to toxocara canis: effect of prechallenge infections and injections of worm extracts. 19705471781
visceral larva migrans (toxocara canis) in calves. 19705462751
toxocara canis infection in baboons. i. antibody, white-cell, and serum-protein responses following infection. 19705443075
an improved hemagglutination technique for detecting antibody against toxocara canis. 19705443074
toxocara canis transmitted by the common house-fly to the canine host. 19705442108
[pseudoglioma of the retina caused by toxocara canis. description of a suspected case]. 19695406016
correspondence scientific, toxocara canis as a support for cholelithiasis in the dog. 19695387809
infections of toxocara canis in dogs fed infected mouse tissues. 19695374712
infections of toxocara canis in dogs fed infected mouse tissues. 19695357321
visceral larva migrans--an immunofluorescent examination of rabbit and human sera for antibodies to the es antigens of the second stage larvae of toxocara canis, toxocara cati and toxascaris leonina (nematoda). 19665327555
[chronic endophthalmitis caused by toxocara canis]. 19715316934
infection of dogs by toxocara canis carried by flies. 19715091367
[a further case of endophthalmos due to toxocara canis]. 19725080363
[chronic endophthalmitis due to toxocara canis]. 19725065031
[visceral larva migrans, toxocara canis (werner, 1782) in man]. 19725063627
[findings related to the 1st ecdysis of ascaris lumbricoides, a. suum and toxocara canis larvae]. 19725049297
invasion of the spinal cord of mice by toxocara canis. 19725022883
ocular toxocara canis. i. experimental immunology. 19715005931
precipitin reactions in monkeys (macaca sinica) experimentally infected with toxocara canis and in children with visceral larva migrans syndrome. 19704991128
toxocara canis infections in baboons. ii. distribution of larvae and histopathologic responses. 19704989284
studies on the liver, lung, brain and blood of experimental animals infected with toxocara canis. 19694986046
further toxocara skin sensitivity tests in animals experimentally infected with toxocara canis. 19694978467
purification and immunochemical analysis of a genus-specific cuticular antigen of toxocara canis. 19694978144
immunological response of rabbits to toxocara canis infection. 19684966889
toxocara skin sensitivity tests and other observations in animals experimentally infected with toxocara canis. 19674965930
antigenic analysis of a metazoan parasite, toxocara canis. i. extraction and assay of antigens. 19674961050
immediate hypersensitivity and serological responses in guinea pigs infected with toxocara canis or trichinella spiralis. 19654953925
[ocular manifestations caused by migrating larva of toxocara canis]. 19694901863
the geography of ocular toxocara canis. 19744821365
helminthiasis in dogs in uganda. i. recovery of strongyloides stercoralis by lindsey's method. ii. recover of dirofilaria repens. iii. aberrant habitation by ancylostomum caninum, spirocerca lupi and toxocara canis. 19734802495
the nature of resistance of immune puppies to superinfection with toxocara canis: evidence that immunity affects second-but not fourth-stage larvae. 19734722664
thiabendazole for control of toxocara canis in the dog. 19734691488
[the visceral larva migrans syndrome due to toxocara canis]. 19724677981
experimental studies on visceral larva migrans of toxocara canis in laboratory animals. 19724669287
a study of the effect of diethylcarbamazine and thiabendazole on experimental toxocara canis infection in mice. 19724668710
toxocara canis: some characteristics of larval precipitating antibodies in rat serum. 19724661481
the distribution of toxocara canis larvae in the central nervous system of rodents. 19724653047
[intraocular infection by toxocara canis]. 19724638564
preparation of sterile toxocara canis larvae. 19744474384
[erg- and eog-examination results in cases of toxocara canis retinochorioiditis (author's transl)]. 19744449170
toxocara canis infestation with encephalitis. 19744434267
ascaris suum infection in calves. i. clinical signs.clinical signs consistent with those of atypical interstitial pneumonia (aip) were induced in calves sensitized with infective ascaris suum eggs at seven to 20 weeks of age and challenged at three-week intervals one or more times. these signs usually appeared on the sixth or seventh day postinfection and reached maximum severity between the tenth and 13th days following infection. prominent signs were: dyspnea, often with expiratory grunt, coughing, mouth breathing and emphysema as well as incre ...19704394225
electron microscopy of the lung in experimental toxocara canis infection. 19744368663
parasites of dogs from indian settlements in northwestern canada: a survey with public health implications.a total of 959 faecal samples were obtained from dogs in 12 native communities in northern saskatchewan, central and northern alberta and the northwest territories. all samples were examined using a flotation technique. samples from an area of endemic human amoebic infections were also examined by a formol-ether sedimentation method. eighteen necropsies were performed. entamoeba histolytica cysts were recovered from dog faeces at loon lake, saskatchewan. toxocara canis had low incidence in saska ...19734265550
[immunofluorescence diagnosis of experimental infection of mice with toxocara canis. antigen testing for the diagnosis of the disease in humans]. 19714258399
ascaris suum infection in calves. 3. pathology.gross changes in the lungs of ascaris suum- infected calves consisted of atelectasis and hemorrhagic foci, edema and emphysema, frequently with bullae. prominent microscopic lung lesions were edema and emphysema of the interlobular septa with large numbers of eosinophils within and around lymphatics, peribronchiolar lymphoid nodules and parasitic granulomas. many of the microscopic features were consistent with those found in atypical interstitial pneumonia. changes in the alveoli were atelectas ...19704248444
amino acid composition of ascaris lumbricoides, a. suum and toxocara canis. 19684234371
immunoglobulin class of antibodies in monkeys infected with toxocara canis. 19744219215
ascaris suum and toxocara canis: radioautographic detection of dna in feulgen-negative muscle nuclei. 19704192595
antigenic analysis of a metazoan parasite, toxocara canis. ii. purification and analysis of two antigenic components. 19674165232
[immunological diagnosis of larva migrans visceralis infection caused by toxocara canis (author's transl)]. 19744134613
the effect of toxocara canis on the spontaneous running activity of mice. 19854096567
transfer of infection-induced immune protection to toxocara canis in a mouse model.groups of mice were vaccinated twice with soluble extracts of embryonated eggs, females or males of toxocara canis, or horse serum, and infected with 2,000 homologous embryonated eggs. recovery of larvae on the fifth day by digestion of mesenteric lymph nodes, liver, lung, brain, and carcass revealed a slight but nonsignificant protection elicited by the parasite materials. other groups were immunized by homologous infections. a single, 200-day-old infection increased importantly the number of l ...19854090262
anthelmintic efficacy of flubendazole paste against nematodes and cestodes in dogs and cats.small dogs and cats, naturally infected with nematodes and cestodes, were used in a critical test under laboratory conditions to determine the palatability and efficacy of flubendazole as a past formulation. subsequently, a control test in dogs was conducted under field conditions. a 4.4% past formulation was given at a dosage of 22 mg/kg of body weight once a day for 2 or 3 consecutive days. in a critical test in dogs, the efficacy against toxocara canis was 97.4% after a 2-day administration a ...19854083589
behavioral effects of early lead exposure and subsequent toxocariasis in mice.mice were maintained under standard conditions, or treated with lead from birth, until they were approximately 40 d of age. at that time the lead solution was replaced with tap water and all animals were gastrointestinally intubated with either the parasite toxocara canis or normal saline. at 2-5 wk following intubation the behavioral effects of t. canis in combination with the prior history of lead ingestion were compared to those produced by administration of either t. canis or lead alone or a ...19854078936
[effect of fenbendazole on resting somatic larvae of toxocara canis werner 1782 (anisakidae) in the pregnant bitch]. 19854072489
prenatal and lactational transmission of toxocara canis and ancylostoma caninum: experimental infection of the bitch at midpregnancy and at parturition. 19854066142
ocular toxocariasis studied by ct scanning.ocular toxocara canis infection causing larval granulomatosis and leading to chronic endophthalmitis and retinal detachment is a well-defined cause of unilateral leukokoria in children. the computed tomographic (ct) scan revealed a diffuse, nonenhancing, well-defined hyperdense lesion occupying most of the globe. the ct findings do not definitively differentiate the diffuse endophthalmitis of larval granulomatosis from retinoblastoma or other pseudogliomas.19854059556
the progression of behavioral and pathological effects of the parasite toxocara canis in the mouse.toxocara canis, the parasitic roundworm of the dog may infect aberrant hosts including mice and humans. the present study examined the behavioral and pathological changes at each of three postintubation periods (period 1: 8-10 days, 2: 49-51 days, and 3: 84-86 days postintubation, respectively) in independent groups of mice intubated with 1000 eggs of t. canis. eight-ten days after intubation toxocara infected animals typically showed depressed levels of activity relative to saline-intubated con ...19854059398
seroprevalence of zoonotic toxocariasis in the united states: 1971-1973.demographic characteristics associated with human toxocara canis infection in children aged one to 11 years were investigated using data from the health and nutrition examination survey of 1971 to 1973. an enzyme-linked immunosorbent assay with larval stage antigen was used to measure the concentration of antibodies to t. canis in 1,409 available sera. from 4.6 to 7.3% of the children in different geographic regions of the united states have been infected, with serologic prevalence approaching 3 ...19854050776
the radioallergosorbent test (rast) for the serological diagnosis of human anisakiasis.the serum of patients with parasitologically confirmed and one patient with a clinically presumptive case of anisakiasis were tested by the radioallergosorbent test (rast) and counter-electrophoresis (cep) for ige and igg antibodies, respectively, using antigens prepared from larval (l3) stage anisakis simplex and larval (l2) stage toxocara canis. all sera were rast-positive to the a. simplex antigen and rast-negative to the t. canis antigen. all sera were cep-negative to both antigens. the pres ...19854039859
toxocara canis larvae in the brain of a british child.the clinical and autopsy findings of a two and a half year-old infant with toxocara sp. infection of the brain and granulomatous lesions in the liver are reported. the cause of death was non-accidental injury. the relationship between toxocara infection and behavioural disorders is discussed.19854035735
regulation of toxocariasis in mice selectively reared for high and low immune responses to nematospiroides dubius.test mice have been selectively reared for high (h) or low (l) immune responses to nematospiroides dubius. after secondary infection with n. dubius, the l mice voided ten times as many eggs in their faeces as the h mice, and at necropsy, 71% versus 20% of the inoculum of n. dubius were recovered as adult worms from the l and h mice respectively. furthermore, n. dubius were more fecund in the l than in h mice. high or low immune responsiveness was not restricted to n. dubius infection in these mi ...19854031456
biosynthetic labelling of the excretory and secretory antigens of toxocara canis larvae.toxocara canis larvae were cultured in vitro in medium containing [35s-]methionine for six days. the medium and the larval tissues were analysed for biosynthetically labelled polypeptides by sodium dodecyl sulphate polyacrylamide gel electrophoresis and autoradiography. immunoprecipitates with positive and negative human antiserum were similarly analysed, using staphylococcus aureus to absorb immunocomplexes. the larvae secrete biosynthetically labelled polypeptides into the medium, with three m ...19854031454
anthelmintic efficacy of febantel combined with praziquantel in dogs.ninety-four dogs were randomly assigned to 1 of 6 groups (5 treated and 1 untreated control) for evaluation of anthelmintic efficacy. three anthelmintic formulations were studied: a febantel paste, a praziquantel paste, and a combination paste containing both active ingredients. treated dogs were dosed once daily for 3 days. the minimal effective dosages in combination were established as 10 mg of febantel and 1 mg of praziquantel/kg of body weight. at those dosages for the combination, 99.5% to ...19854030460
do toxocara canis larval antigens used in enzyme-linked immunosorbent assay for visceral larva migrans cross-react with ab isohemagglutinins and give false positive results?a variety of helminth parasites have a and b blood group antigens on their surface. these antigens may cross-react with elevated concentrations of a and b isohemagglutinins in some patients and give false-positive results in the serologic diagnosis of visceral larva migrans caused by t. canis. to clarify this point, serum from patients with visceral larva migrans and elevated t. canis antibody titers as determined by elisa were absorbed with ab blood cells and retested by elisa without a demonst ...19854013469
induction of a marked eosinophilia by cyclophosphamide in toxocara canis infected sjl mice.cyclophosphamide (cy) is known to produce a marked eosinophilia in mice after antigen challenge. in this study, we studied the effect of cy on eosinophilia in helminthic infection. peripheral blood eosinophils were counted in sjl mice following a large dose of cy injection, infection with toxocara canis, and both cy injection and t. canis infection simultaneously. following the injection with cy (150 mg/kg), the eosinophil counts fell sharply, then rose abruptly to six times the normal level fol ...19854011300
immune responses of cba/j mice to graded infections with toxocara canis.the immunological responsiveness of cba/j mice infected with various numbers of the canine ascarid, toxocara canis, was characterized after a single infection to ascertain the smallest infection capable of perturbing the immune system of the host. mice receiving the lowest inoculations (5 eggs per mouse or 0.25 larvae per g of body weight) had detectable alterations in the number of circulating peripheral blood eosinophils and spleen weight-to-body weight ratios. mice infected with 25 eggs each ...19853997242
in vitro translation of mrna from toxocara canis larvae.300 micrograms of total rna was extracted from 1 ml of packed toxocara canis larvae by centrifugation through a 5.7 m cesium chloride cushion. 60 micrograms of polyadenylated messenger rna was separated from 300 micrograms of total rna in an oligothymidylic acid-cellulose gel column. the in vitro translation of the mrna, isolated from t. canis larvae, was carried out using the rabbit reticulocyte cell-free translation system. incorporation of [35s]methionine into trichloroacetic acid precipitabl ...19853990707
toxocara canis in humans. 19853980978
prenatal and lactational transmission of toxocara canis and ancylostoma caninum: experimental infection of the bitch before pregnancy. 19853980144
induction of non-ige anaphylactic antibodies in dogs.dogs immunized with o-dncp-bsa or eggs of toxocara canis developed anaphylactic antibodies other than ige. the antibodies were heat-resistant at 56 degrees c for 2 hours, not reduced by 2-mercaptoethanol and pca and p-k reactivity was only observed at 3-4 h sensitized sites of recipient skin. high titres of antigen-specific iggd were determined by means of an elisa technique.19853978874
[migration and distribution of toxocara canis werner 1782 (anisakidae) larvae in the definitive host (beagle) following primary infection and reinfection]. 19853976310
specific antibody responses in dogs experimentally infected with echinococcus granulosus.six dogs reared helminth-free were divided into 2 groups. four dogs were infected per os with 200,000 protoscoleces each of echinococcus granulosus and 2 were kept as uninfected controls. all the dogs were kept together until 32 days after infection, when 1 infected dog was killed, its intestine removed and the contents examined to confirm that the infection with e. granulosus had been successful. the remaining 3 infected dogs were transferred to high security housing and their feces inspected d ...19863953947
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