Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| prevalence of human papillomavirus infection in the oropharynx and urine among sexually active men: a comparative study of infection by papillomavirus and other organisms, including neisseria gonorrhoeae, chlamydia trachomatis, mycoplasma spp., and ureaplasma spp. | oropharyngeal squamous cell carcinoma (oscc) has shown a gradual increase in male predominance due to the increasing incidence of human papillomavirus (hpv)-associated oscc. however, the mode of hpv transmission to the oral cavity is poorly understood, and little is known about the epidemiology of oral hpv infection in men. the prevalence rates of hpv, neisseria gonorrhoeae, chlamydia trachomatis, mycoplasma spp., and ureaplasma spp. were compared in the oropharynx (oral cavity) and urine of mal ... | 2014 | 24468054 |
| the e2-like conjugation enzyme atg3 promotes binding of irg and gbp proteins to chlamydia- and toxoplasma-containing vacuoles and host resistance. | cell-autonomous immunity to the bacterial pathogen chlamydia trachomatis and the protozoan pathogen toxoplasma gondii is controlled by two families of interferon (ifn)-inducible gtpases: immunity related gtpases (irgs) and guanylate binding proteins (gbps). members of these two gtpase families associate with pathogen-containing vacuoles (pvs) and solicit antimicrobial resistance pathways specifically to the intracellular site of infection. the proper delivery of irg and gbp proteins to pvs requi ... | 2014 | 24466199 |
| the intracellular bacteria chlamydia hijack peroxisomes and utilize their enzymatic capacity to produce bacteria-specific phospholipids. | chlamydia trachomatis is an obligate intracellular pathogen responsible for loss of eyesight through trachoma and for millions of cases annually of sexually transmitted diseases. the bacteria develop within a membrane-bounded inclusion. they lack enzymes for several biosynthetic pathways, including those to make some phospholipids, and exploit their host to compensate. three-dimensional fluorescence microscopy demonstrates that small organelles of the host, peroxisomes, are translocated into the ... | 2014 | 24465954 |
| prevalence of sexually transmitted infections among healthy korean women: implications of multiplex pcr pathogen detection on antibiotic therapy. | in this study, we investigated the prevalence of sexually transmitted infections (stis) using multiplex real-time pcr assay in healthy korean women. we also evaluated the risk factors of stis, and compared the various factors between the sti-positive and the sti-negative groups. a total of 799 endocervical swab samples from healthy korean women who visited our hospital for general medical check-ups during january 2012 to october 2012 were included. eight stis including human papillomavirus (hpv) ... | 2014 | 24462432 |
| the value of simple microbiological studies for on-site screening of acute neonatal conjunctivitis in angola. | neonatal conjunctivitis or ophthalmia neonatorum (on) is an acute bacterial conjunctivitis contracted by newborns during delivery. in non-industrialized countries, detection of the etiological agent is difficult due to the unavailability of modern diagnostic resources. therefore, we analyzed the effectiveness of gram and methylene blue staining techniques, which are simple microbiological methods in suspecting the aetiology of on in a maternity ward in luanda, angola. | 2014 | 24460893 |
| development of a rectal sexually transmitted infection--hiv coinfection model utilizing chlamydia trachomatis and shivsf162p3. | rectal sexually transmitted infections (stis) may increase hiv susceptibility in men who have sex with men (msm), and chlamydia trachomatis is prevalent among hiv-positive msm. to study stis and hiv infection in msm, we first evaluated whether cynomolgus macaques can sustain both c. trachomatis and shivsf162p3 infections. | 2014 | 24460742 |
| complete genome sequence of chlamydia trachomatis ocular serovar c strain tw-3. | chlamydia trachomatis is the etiological agent of trachoma, the leading infectious cause of blindness worldwide. we report here the first complete and annotated genome of a c. trachomatis trachoma-causing serovar c strain (strain tw-3). the chromosome and plasmid are 1,043,554 bp and 7,501 bp in length, respectively. | 2014 | 24459269 |
| hepatitis b virus surface antigen as delivery vector can enhance chlamydia trachomatis momp multi-epitope immune response in mice. | chlamydia trachomatis is the leading cause of sexually transmitted infections worldwide. there is currently no commercially available vaccine against c. trachomatis. major outer membrane protein (momp) of c. trachomatis is considered to be an ideal candidate for prophylactic vaccine. we designed a momp multi-epitope containing t- and b-cell epitope-rich peptides and developed hepatitis b surface antigen (hbsag) as antigen delivery vehicle. in order to study the immunogenicity and efficacy of the ... | 2014 | 24458565 |
| correlates of chlamydia and gonorrhea infection among female sex workers: the untold story of jiangsu, china. | to estimate the prevalence of sexually transmitted infections (stis) among female sex workers (fsws) in the jiangsu province, china and measure the association of chlamydia trachomatis (ct) and neisseria gonorrhoeae (ng) infections with their potential correlates. | 2014 | 24454950 |
| review of use of a new rapid real-time pcr, the cepheid genexpert® (xpert) ct/ng assay, for chlamydia trachomatis and neisseria gonorrhoeae: results for patients while in a clinical setting. | rapid diagnostics for chlamydia trachomatis and neisseria gonorrhoeae are desirable so that patients can be treated while they are still in the clinic or doctor's office. the cepheid genexpert(®) (xpert) ct/ng assay was us fda-cleared in december 2012. the assay is a rapid real-time pcr nucleic acid amplified test. the cartridge-based assay detects dna of chlamydia trachomatis and neisseria gonorrhoeae. it is fda-cleared for use in female endocervical swabs, patient-collected vaginal swabs and f ... | 2014 | 24450867 |
| reinfection by untreated partners of people treated for chlamydia trachomatis and neisseria gonorrhoeae: mathematical modelling study. | reinfection after treatment for chlamydia trachomatis or neisseria gonorrhoeae reduces the effect of control interventions. we explored the impact of delays in treatment of current partners on the expected probability of reinfection of index cases using a mathematical model. | 2014 | 24448560 |
| cohort and age effects of mass drug administration on prevalence of trachoma: a longitudinal study in rural tanzania. | mass drug administration (mda) is part of the safe strategy for trachoma elimination. this study examined the effect of three annual mdas on prevalence of trachoma among 13 longitudinal cohorts of tanzanian children. | 2014 | 24448262 |
| is there evidence for resistance of ocular chlamydia trachomatis to azithromycin after mass treatment for trachoma control? | trachoma, caused by repeated infections with ocular chlamydia trachomatis, is targeted for elimination using multiple annual rounds of mass drug administration (mda) in endemic communities. infection rates do not decline as expected in some communities, leading to concerns about azithromycin resistance. | 2014 | 24446528 |
| expression and targeting of secreted proteins from chlamydia trachomatis. | chlamydia trachomatis is an obligate intracellular pathogen that replicates in a vacuole termed the inclusion. many of the interactions of chlamydiae with the host cell are dependent upon bacterial protein synthesis and presumably exposure of these proteins to the cytosol. because of the dearth of genetic tools for chlamydiae, previous studies examining secreted proteins required the use of heterologous bacterial systems. recent advances in genetic manipulation of chlamydia now allow for transfo ... | 2014 | 24443531 |
| co-infection of mycoplasma genitalium and chlamydia trachomatis in an infertile female patient with genital tuberculosis. | genital tuberculosis is a common cause of female infertility in india. but, it is important to screen for other agents like chlamydia trachomatis and genital mycoplasmas as well to avoid persistence of infection and its long-term sequelae. timely diagnosis of these infections using nucleic acid amplification tests and institution of appropriate therapy will improve the conception rates in infertile women. we report a case of co-infection of mycoplasma genitalium and chlamydia trachomatis in an i ... | 2014 | 24441248 |
| chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth. | intracellular pathogens directly alter host cells in order to replicate and survive. while infection-induced changes in host transcription can be readily assessed, posttranscriptional alterations are more difficult to catalog. we applied the global protein stability (gps) platform, which assesses protein stability based on relative changes in an adjoining fluorescent tag, to identify changes in the host proteome following infection with the obligate intracellular bacteria chlamydia trachomatis. ... | 2014 | 24439903 |
| valuing the health states associated with chlamydia trachomatis infections and their sequelae: a systematic review of economic evaluations and primary studies. | economic evaluations of interventions to prevent and control sexually transmitted infections such as chlamydia trachomatis are increasingly required to present their outcomes in terms of quality-adjusted life-years using preference-based measurements of relevant health states. the objectives of this study were to critically evaluate how published cost-effectiveness studies have conceptualized and valued health states associated with chlamydia and to examine the primary evidence available to info ... | 2014 | 24438725 |
| an atypical cd8 t-cell response to chlamydia muridarum genital tract infections includes t cells that produce interleukin-13. | chlamydia trachomatis urogenital serovars d-k are intracellular bacterial pathogens that replicate almost exclusively in human reproductive tract epithelium. in the c. muridarum mouse model for human chlamydia genital tract infections cd4 t helper type 1 cell responses mediate protective immunity while cd8 t-cell responses have been associated with scarring and infertility. scarring mediated by cd8 t cells requires production of tumour necrosis factor-α (tnf-α); however, tnf-α is associated with ... | 2014 | 24428415 |
| [the importance of using a test to detect chlamydia trachomatis infection in patients undergoing counseling and testing for sexually transmitted diseases at a public health center]. | serum levels of antibody against chlamydia trachomatis are used routinely to diagnose chlamydial infection among patients undergoing counseling and testing for sexually transmitted disease at public health centers in japan, whereas tests for pathogen detection are conducted at most clinics. the objective of the present study was to evaluate the usefulness of a test for detecting c. trachomatis and to compare it with that of screening for serum chlamydia antibodies at a public health center. | 2013 | 24418917 |
| an association between trichomonas vaginalis and high-risk human papillomavirus in rural tanzanian women undergoing cervical cancer screening. | the goal of this study was to determine the prevalence of vaginitis and its association with high-risk human papillomavirus (hr hpv) in women undergoing cervical cancer screening in rural tanzania. | 2014 | 24417784 |
| prevalence and diagnostic significance of specific iga and anti-heat shock protein 60 chlamydia trachomatis antibodies in subfertile women. | the objective of the present study was to evaluate the clinical usefulness of the simultaneous measurement of three serological markers of chlamydial infection in women with tubal factor infertility (tfi) and spontaneous miscarriage. serum was collected from 87 patients (33 with tfi and 54 with spontaneous miscarriage) and analyzed for the presence of igg and iga antibodies against chlamydia trachomatis momp antigen (dia.pro) and igg antibodies to chlamydial heat shock protein 60 (chsp60) antige ... | 2014 | 24413970 |
| comparing azithromycin and doxycycline for the treatment of rectal chlamydial infection: a retrospective cohort study. | centers for disease control and prevention guidelines recommend azithromycin or doxycycline for treatment of rectal chlamydial infection. | 2014 | 24413484 |
| prevalence of ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis infections, and semen quality in infertile and fertile men in china. | to study the prevalence of ureaplasma urealyticum (uu), mycoplasma hominis (mh), and chlamydia trachomatis (ct) infections among infertile and fertile men and to study the effects of these infections on semen quality. | 2014 | 24411218 |
| male immunity to the chlamydial 60 kda heat shock protein (hsp 60) - associated with semen quality? | the role of chlamydia trachomatis for male infertility is a matter of constant debate. it is assumed that in its persistent form this pathogen may produce high levels of 60 kd heat shock protein (chlam hsp60). cross-reactivity between epitopes of the bacterial and human hsps, involved in many steps of the reproductive process, might induce an autoimmune response with potential impairment of semen quality and sperm fertilising capacity. this prospective study included asymptomatic males of a tota ... | 2015 | 24404853 |
| type-specific human papillomavirus biological features: validated model-based estimates. | infection with high-risk (hr) human papillomavirus (hpv) is considered the necessary cause of cervical cancer. vaccination against hpv16 and 18 types, which are responsible of about 75% of cervical cancer worldwide, is expected to have a major global impact on cervical cancer occurrence. valid estimates of the parameters that regulate the natural history of hrhpv infections are crucial to draw reliable projections of the impact of vaccination. we devised a mathematical model to estimate the prob ... | 2013 | 24400036 |
| chlamydia trachomatis infection and human papillomavirus in women with cervical neoplasia in pernambuco-brazil. | chlamydia trachomatis (ct) is the most common bacterial cause of sexually transmitted disease. high-risk human papillomavirus (hr-hpv) is considered the main etiological agent for cervical neoplasia. evidences showed that the presence of co-infection of ct and hr-hpv plays a central role in the etiology of cervical intraepithelial neoplasia (cin) and cervical cancer. the goals of this study were: evaluate the human papillomavirus (hpv) and ct prevalence among brazilian women with abnormal cytolo ... | 2014 | 24395291 |
| the protease inhibitor jo146 demonstrates a critical role for cthtra for chlamydia trachomatis reversion from penicillin persistence. | the chlamydia trachomatis serine protease htra (cthtra) has recently been demonstrated to be essential during the replicative phase of the chlamydial developmental cycle. a chemical inhibition strategy (serine protease inhibitor jo146) was used to demonstrate this essential role and it was found that the chlamydial inclusions diminish in size and are lost from the cell after cthtra inhibition without formation of viable elementary bodies. the inhibitor (jo146) was used in this study to investiga ... | 2013 | 24392355 |
| site-specific, insertional inactivation of inca in chlamydia trachomatis using a group ii intron. | chlamydia trachomatis is an obligate, intracellular bacterial pathogen that has until more recently remained recalcitrant to genetic manipulation. however, the field still remains hindered by the absence of tools to create selectable, targeted chromosomal mutations. previous work with mobile group ii introns demonstrated that they can be retargeted by altering dna sequences within the intron's substrate recognition region to create site-specific gene insertions. this platform (marketed as target ... | 2013 | 24391860 |
| potential influence of the microbiome on infertility and assisted reproductive technology. | although an altered vaginal microbiota has been demonstrated to affect parturition, its role in assisted reproductive technologies is uncertain. nevertheless, the effect of known pathogens such as mycoplasma tuberculosis, chlamydia trachomatis, and neisseria gonorrhoeae is clear, causing subclinical changes thought to be risk factors in subfertility. the human microbiome project (hmp) has allowed for metagenomic studies to aid in characterizing normal vaginal flora. recent findings from the hmp ... | 2014 | 24390919 |
| associated factors with and genotypes of chlamydia trachomatis infection among clients seeking voluntary counseling and testing for hiv infection in taiwan. | this study aimed to investigate the factors associated with chlamydia trachomatis infection and the genotype distribution of the strains among the clients seeking voluntary counseling and testing (vct) for human immunodeficiency virus (hiv) in taiwan. | 2014 | 24387885 |
| serovar d and e of serogroup b induce highest serological responses in urogenital chlamydia trachomatis infections. | chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection (sti) worldwide. a strong link between c. trachomatis serogroup/serovar and serological response has been suggested in a previous preliminary study. the aim of the current study was to confirm and strengthen those findings about serological igg responses in relation to c. trachomatis serogroups and serovars. | 2014 | 24383586 |
| chlamydia trachomatis infection in hiv-infected women: need for screening by a sensitive and specific test. | reproductive tract infection (rtis)/sexually transmitted infections (stis) are recognized as a major public health problem, particularly due to their relationship with hiv infection. early detection and treatment of chlamydia trachomatis infection (cti) among hiv-infected and hiv-uninfected women may impact heterosexual hiv transmission. a total of 120 participants were enrolled: 30 hiv seropositive women with symptoms of rtis, 30 hiv seropositive women without symptoms of rtis, 30 hiv seronegat ... | 2013 | 24382941 |
| enigmatic question of early reactive arthritis disclosed after researches of mycoplasmas, chlamydia trachomatis and enteropathogens following the holistic vision of human being. | an hla-b27 genetic profile patient is fully investigated by molecular analyses after an anamnestic assessment of multi-site ecosystems, following the holistic vision of human being.vdrl and widal-wright (wwr) resulted positive, showing at wrights reaction a title of 1:40. of all the enzymatic activities measured, only the alp enzymatic pool activities showed a low increasing value of 297 u/l. of all later acute phase proteins, only c3 c protein value (127 mg/dl) and fibrinogen (376 mg/dl) were ... | 2014 | 24382185 |
| laboratory diagnosis of persistent human chlamydial infection. | diagnostic assays for persistent chlamydial infection are much needed to conduct high-quality, large-scale studies investigating the persistent state in vivo, its disease associations and the response to therapy. yet in most studies the distinction between acute and persistent infection is based on the interpretation of the data obtained by the assays developed to diagnose acute infections or on complex assays available for research only and/or difficult to establish for clinical use. novel biom ... | 2013 | 24381934 |
| detection of chlamydia trachomatis and neisseria gonorrhoeae in an sti population: performances of the presto ct-ng assay, the lightmix kit 480 ht ct/ng and the cobas amplicor with urine specimens and urethral/cervicovaginal samples. | this study assessed the performances of the presto ct-ng assay, the lightmix kit 480 ht ct/ng and the cobas amplicor for chlamydia trachomatis and neisseria gonorrhoeae detection. | 2013 | 24381252 |
| infectivity of urogenital chlamydia trachomatis plasmid-deficient, ct135-null, and double-deficient strains in female mice. | chlamydia trachomatis is the most common cause of human bacterial sexually transmitted infections and is the world's leading cause of infectious preventable blindness. the chlamydial 7.5-kb plasmid and chromosomal gene ct135 have been shown to be important virulence factors in both nonhuman primate and mouse infection models. chlamydia trachomatis plasmid-deficient urogenital isolates and a predicted ct135 null mutant have been evaluated independently in the female mouse genital tract model and ... | 2014 | 24376189 |
| reactivation of chromosomally integrated human herpesvirus-6 by telomeric circle formation. | more than 95% of the human population is infected with human herpesvirus-6 (hhv-6) during early childhood and maintains latent hhv-6 genomes either in an extra-chromosomal form or as a chromosomally integrated hhv-6 (cihhv-6). in addition, approximately 1% of humans are born with an inheritable form of cihhv-6 integrated into the telomeres of chromosomes. immunosuppression and stress conditions can reactivate latent hhv-6 replication, which is associated with clinical complications and even deat ... | 2013 | 24367281 |
| cross-sectional study of pharyngeal and genital chlamydia and gonorrhoea infections in emergency department patients. | chlamydia trachomatis (ct) and neisseria gonorrhoeae (gc) are the most commonly reported diseases in the usa, with increasing concern regarding cephalosporin-resistant gc strains and growing discussion of routine male screening and analysing extragenital sites. hospital emergency departments (eds) may be appropriate screening venues, and our objective was to identify the extent of genital and oropharyngeal ct/gc infection in ed patients. | 2014 | 24366777 |
| in vitro activity of nemonoxacin, a novel nonfluorinated quinolone antibiotic, against chlamydia trachomatis and chlamydia pneumoniae. | the in vitro activities of nemonoxacin, levofloxacin, azithromycin, and doxycycline were tested against 10 isolates each of chlamydia trachomatis and chlamydia pneumoniae. the mics at which 90% of the isolates of both c. trachomatis and c. pneumoniae were inhibited (mic90s) were 0.06 μg/ml (range, 0.03 to 0.13 μg/ml). the minimal bactericidal concentrations at which 90% of the isolates were killed by nemonoxacin (mbc90s) were 0.06 μg/ml for c. trachomatis (range, 0.03 to 0.125 μg/ml) and 0.25 fo ... | 2014 | 24366753 |
| characterization of protective immune responses promoted by human antigen targets in a urogenital chlamydia trachomatis mouse model. | a vaccine against genital tract infections caused by chlamydia trachomatis is urgently needed. we have previously identified a number of immunodominant human t- and/or b-cell antigen targets in patients with a c. trachomatis infection. herein we use a urogenital c. trachomatis mouse model to investigate the protective efficacy of these antigens. c3h/hen mice were immunized with recombinant antigens formulated in the adjuvant caf01. immunity post vaccination was analyzed and the protective effica ... | 2014 | 24365515 |
| performance of an automated multiplex immunofluorescence assay for detection of chlamydia trachomatis immunoglobulin g. | chlamydia serology is indicated to investigate etiology of miscarriage, infertility, pelvic inflammatory disease, and ectopic pregnancy. here, we assessed the reliability of a new automated-multiplex immunofluorescence assay (inodiag test) to detect specific anti-c. trachomatis immunoglobulin g. considering immunofluorescence assay (if) as gold standard, inodiag tests exhibited similar sensitivities (65.5%) but better specificities (95.1%-98%) than enzyme-linked immunosorbent assays (elisas). in ... | 2014 | 24365033 |
| a review of serological tests to assist diagnosis of reactive arthritis: critical appraisal on methodologies. | on a population-based level, the incidence of reactive arthritis (rea) is 0.6-27/100,000. the definition of rea varies and its pathogenesis is not yet clear. attempts in basic immunology to suggest hypotheses for proliferation of forbidden b cell clones, molecular mimicry, and involvement of cross-reactive antibodies are helpful but not sufficient. importantly, for the clinical diagnosis of the preceding infection, serology is widely used. unfortunately, the accuracy of associations between sero ... | 2013 | 24363655 |
| transformation of chlamydia muridarum reveals a role for pgp5 in suppression of plasmid-dependent gene expression. | transformation of chlamydia trachomatis should greatly advance the chlamydial research. however, significant progress has been hindered by the failure of c. trachomatis to induce clinically relevant pathology in animal models. chlamydia muridarum, which naturally infects mice, can induce hydrosalpinx in mice, a tubal pathology also seen in women infected with c. trachomatis. we have developed a c. muridarum transformation system and confirmed pgp1, -2, -6, and -8 as plasmid maintenance factors, ... | 2014 | 24363344 |
| chlamydia trachomatis ct771 (nudh) is an asymmetric ap4a hydrolase. | asymmetric diadenosine 5',5‴-p(1),p(4)-tetraphosphate (ap4a) hydrolases are members of the nudix superfamily that asymmetrically cleave the metabolite ap4a into atp and amp while facilitating homeostasis. the obligate intracellular mammalian pathogen chlamydia trachomatis possesses a single nudix family protein, ct771. as pathogens that rely on a host for replication and dissemination typically have one or zero nudix family proteins, this suggests that ct771 could be critical for chlamydial biol ... | 2014 | 24354275 |
| pd-l1 limits the mucosal cd8+ t cell response to chlamydia trachomatis. | chlamydia trachomatis infection is the most common bacterial sexually transmitted disease in the united states. repeated infections with c. trachomatis lead to serious sequelae, such as infertility. it is unclear why the adaptive immune system, specifically the cd8(+) t cell response, is unable to protect against subsequent c. trachomatis infections. in this article, we characterize the mucosal cd8(+) t cell response to c. trachomatis in the murine genital tract. we demonstrate that the immunoin ... | 2014 | 24353266 |
| exploration of gender differences of chlamydia trachomatis infection amongst young people reveals limitations of using sexual histories to assess risk in high-prevalence areas. | in england, chlamydia positivity in young men occurs at a slightly older age group (20-24 years) than positivity among young women (16-20 years) but total rates of infection among the population aged under 25 years are similar. where there is variation, explanations often focus on individual sexual risk behaviours. we aimed to explore the extent to which variations in chlamydia positivity could be explained by reasons for attendance and sexual behaviour at a sexual health clinic in a high-preval ... | 2014 | 24352135 |
| rectal chlamydia in heterosexual women: more questions than answers. | the aim of this study was to observe the proportion of concurrent rectal chlamydia (rct) infection in women who have cervical chlamydia (cct) and to observe whether there was any correlation with receptive anal intercourse (rai). untreated cct-positive women were invited to take part. women chose either to have a physician-collected or self-taken rectal swab. treatment was then commenced. 17 samples were physician-collected and 80 were self-collected. 75/97 (77.3%, 95% confidence interval [95%ci ... | 2014 | 24352134 |
| 2013 european guideline on the management of proctitis, proctocolitis and enteritis caused by sexually transmissible pathogens. | proctitis is defined as an inflammatory syndrome of the distal 10-12 cm of the anal canal, also called the rectum. infectious proctitis can be sexually transmitted via genital-anal mucosal contact, but some also via mutual masturbation.n. gonorrhoeae,c. trachomatis(including lymphogranuloma venereum), herpes simplex virus andt. pallidumare the most common sexually transmitted anorectal pathogens. shigellosis can be transferred via oral-anal contact and may lead to proctocolitis or enteritis. alt ... | 2014 | 24352129 |
| chlamydia trachomatis infection during pregnancy: knowledge, test practices, and attitudes of dutch midwives. | chlamydia trachomatis infection in pregnancy may lead to adverse pregnancy outcomes. in the netherlands, testing for c. trachomatis is based on risk assessment. we assessed midwives' knowledge, test practices, assessment of risk behavior, and attitudes regarding testing for c. trachomatis infection during pregnancy. we evaluated the association between midwives' characteristics and their knowledge of c. trachomatis infection in terms of symptomatology and outcomes. | 2014 | 24350790 |
| chlamydia trachomatis infection: implications for hpv status and cervical cancer. | genital chlamydia trachomatis (ct) infections have been identified as a major health problem concern. ct is associated with adverse effect on women reproduction and also associated with cervical hypertrophy and induction of squamous metaplasia, providing a possible relationship with human papillomavirus (hpv) infection. infection by high-risk hpv types is crucial to the pathogenesis of invasive cervical cancer (icc), but other co-variants/cofactors must be present for the development of malignan ... | 2014 | 24346121 |
| chlamydia trachomatis-infected epithelial cells and fibroblasts retain the ability to express surface-presented major histocompatibility complex class i molecules. | the obligate intracellular bacterial pathogen chlamydia trachomatis is the causative agent of a variety of infectious diseases such as trachoma and sexually transmitted diseases. in infected target cells, c. trachomatis replicates within parasitophorous vacuoles and expresses the protease-like activity factor cpaf. previous studies have suggested that cpaf degrades the host transcription factors rfx5 and nf-κb p65, which are involved in the regulation of constitutive and inducible expression of ... | 2014 | 24343651 |
| reduced live organism recovery and lack of hydrosalpinx in mice infected with plasmid-free chlamydia muridarum. | plasmid-free chlamydia trachomatis and chlamydia muridarum fail to induce severe pathology. to evaluate whether the attenuated pathogenicity is due to insufficient infection or inability of the plasmidless chlamydial organisms to trigger pathological responses, we compared plasmid-competent and plasmid-free c. muridarum infections in 5 different strains of mice. all 5 strains developed hydrosalpinx following intravaginal inoculation with plasmid-competent, but not inoculation with plasmid-free, ... | 2014 | 24343644 |
| [comparison of two techniques for serological diagnosis of chlamydial infections: mif and immunoblotting]. | sera from a population of 58 patients were used for comparison of two techniques for serodiagnosis of chlamydia species: the mif (micro-immunofluorescence) and immunoblotting. the mif uses elementary bodies (ec) of chlamydia while immunoblotting using recombinant proteins specific synthetic species of chlamydia. the objective of this study was to determine the sensitivity and specificity of serological techniques evaluated on a population control but also ill, by a comparative study between mif ... | 2013 | 24342787 |
| [leading role of infection in formation of placental insufficiency]. | evaluate the role of endotoxinemia in pregnancy complicated with placental insufficiency. | 2013 | 24341208 |
| [mycoplasma and chlamydia as ethiological factors of bronchial asthma in terms of ethnogenesis]. | the study of the prevalence and clinical peculiarities of mycoplasmosis and chlamydiosis in patients with different pathogenic forms of bronchial asthma (ba) taking into account ethnicity of a patient. | 2013 | 24340964 |
| smoking as a major risk factor for cervical cancer and pre-cancer: results from the epic cohort. | a total of 308,036 women were selected from the european prospective investigation into cancer and nutrition (epic) study to evaluate the association between tobacco smoking and the risk of cervical intraepithelial neoplasia of grade 3 (cin3)/carcinoma in situ (cis) and invasive cervical cancer (icc). at baseline, participants completed a questionnaire and provided blood samples. during a mean follow-up time of 9 years, 261 icc cases and 804 cin3/cis cases were reported. in a nested case-control ... | 2014 | 24338632 |
| prospective seroepidemiologic study on the role of human papillomavirus and other infections in cervical carcinogenesis: evidence from the epic cohort. | to evaluate prospectively the association between serological markers of selected infections, including hpv, and risk of developing cervical cancer (cc) and precancer, we performed a nested case-control study within the european prospective investigation into cancer and nutrition (epic) study that included 184 cases of invasive cc (icc), 425 cases of cervical intraepithelial neoplasia (cin) grade 3 or carcinoma in situ (cis), and 1,218 matched control women. at enrollment participants completed ... | 2014 | 24338606 |
| maternal chlamydia trachomatis infections and preterm birth:the impact of early detection and eradication during pregnancy. | the risks for preterm birth are heterogeneous and there remains much to elucidate regarding etiology of this adverse perinatal outcome. antenatal infection with chlamydia trachomatis, a highly prevalent sexually-transmitted infection, may convey a higher risk of preterm birth. early detection and eradication of this sexually-transmitted infection without recurrent/persistent infection during pregnancy may serve as an intervention that reduces the risk of preterm birth. the objective of this stud ... | 2014 | 24337865 |
| field evaluation of the crt and acon chlamydia point-of-care tests in a tropical, low-resource setting. | to evaluate the clinical performance of two chlamydia point-of-care (poc) tests compared with a gold standard nucleic acid amplification testing (naat). | 2014 | 24337733 |
| neisseria gonorrhoeae and chlamydia trachomatis infection in hiv-1-infected women taking antiretroviral therapy: a prospective cohort study from burkina faso. | neisseria gonorrhoeae (ng) and chlamydia trachomatis (ct) are common sexually transmitted infections (sti). we assessed the cumulative risk of ng and ct in a cohort of hiv-1-infected high-risk women taking antiretrovirals over 4 years in burkina faso. | 2013 | 24337732 |
| detection of chlamydia trachomatis or neisseria gonorrhoeae in otorhinolaryngology patients with pharyngeal symptoms. | 2014 | 24337731 | |
| [epidemiological developments of selected sexually transmitted infections in germany]. | the number of people living with hiv infection has been increasing since the mid 1990s and is expected to rise further in the coming years. the hiv epidemic in germany is still most affected by developments in the group of men who have sex with men (msm). in this group, the number of newly diagnosed hiv infections has increased in recent years especially in large cities. despite increased efforts to motivate hiv-infected people, who were not previously diagnosed, to be tested as early as possibl ... | 2013 | 24337121 |
| a new metabolic cell-wall labelling method reveals peptidoglycan in chlamydia trachomatis. | peptidoglycan (pg), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure. bacteria comprising the chlamydiales were thought to be one of the few exceptions. chlamydia harbour genes for pg biosynthesis and exhibit susceptibility to 'anti-pg' antibiotics, yet attempts to detect pg in any chlamydial species have proven unsuccessful (the 'chlamydial anomaly'). we used a novel approach to metabolically ... | 2014 | 24336210 |
| the sexunzipped trial: young people's views of participating in an online randomized controlled trial. | incidence of sexually transmitted infections (stis) among young people in the united kingdom is increasing. the internet can be a suitable medium for delivery of sexual health information and sexual health promotion, given its high usage among young people, its potential for creating a sense of anonymity, and ease of access. online randomized controlled trials (rcts) are increasingly being used to evaluate online interventions, but while there are many advantages to online methodologies, they ca ... | 2013 | 24334198 |
| sensitive and rapid detection of chlamydia trachomatis by recombinase polymerase amplification directly from urine samples. | chlamydia trachomatis is the most common sexually transmitted human pathogen. infection results in minimal to no symptoms in approximately two-thirds of women and therefore often goes undiagnosed. c. trachomatis infections are a major public health concern because of the potential severe long-term consequences, including an increased risk of ectopic pregnancy, chronic pelvic pain, and infertility. to date, several point-of-care tests have been developed for c. trachomatis diagnostics. although m ... | 2014 | 24331366 |
| evaluation of who screening algorithm for the presumptive treatment of asymptomatic rectal gonorrhoea and chlamydia infections in at-risk msm in kenya. | the who recommends that men who have sex with men (msm) reporting unprotected receptive anal intercourse (rai) and either multiple partners or a partner with a sexually transmitted infection (sti) in the past 6 months should be presumptively treated for asymptomatic rectal neisseria gonorrhoeae (ng) and chlamydia trachomatis (ct) infections. we evaluated this recommendation in a cohort of 'high-risk' msm in coastal kenya. | 2013 | 24327758 |
| subversion of inflammasome activation and pyroptosis by pathogenic bacteria. | activation of the inflammasome occurs in response to a notably high number of pathogenic microbes and is a broad innate immune response that effectively contributes to restriction of pathogen replication and generation of adaptive immunity. activation of these platforms leads to caspase-1- and/or caspase-11-dependent secretion of proteins, including cytokines, and induction of a specific form of cell death called pyroptosis, which directly or indirectly contribute for restriction of pathogen rep ... | 2013 | 24324933 |
| the resveratrol tetramer (-)-hopeaphenol inhibits type iii secretion in the gram-negative pathogens yersinia pseudotuberculosis and pseudomonas aeruginosa. | society faces huge challenges, as a large number of bacteria have developed resistance towards many or all of the antibiotics currently available. novel strategies that can help solve this problem are urgently needed. one such strategy is to target bacterial virulence, the ability to cause disease e.g., by inhibition of type iii secretion systems (t3sss) utilized by many clinically relevant gram-negative pathogens. many of the antibiotics used today originate from natural sources. in contrast, m ... | 2013 | 24324737 |
| simultaneous transcriptional profiling of bacteria and their host cells. | we developed an rna-seq-based method to simultaneously capture prokaryotic and eukaryotic expression profiles of cells infected with intracellular bacteria. as proof of principle, this method was applied to chlamydia trachomatis-infected epithelial cell monolayers in vitro, successfully obtaining transcriptomes of both c. trachomatis and the host cells at 1 and 24 hours post-infection. chlamydiae are obligate intracellular bacterial pathogens that cause a range of mammalian diseases. in humans c ... | 2013 | 24324615 |
| transformation of sexually transmitted infection-causing serovars of chlamydia trachomatis using blasticidin for selection. | plasmid-free chlamydia trachomatis serovar l2 organisms have been transformed with chlamydial plasmid-based shuttle vectors pgfp::sw2 and pbrct using β-lactamase as a selectable marker. however, the recommendation of amoxicillin, a β-lactam antibiotics, as one of the choices for treating pregnant women with cervicitis due to c. trachomatis infection has made the existing shuttle vectors unsuitable for transforming sexually transmitted infection (sti)-causing serovars of c. trachomatis. thus, in ... | 2013 | 24303023 |
| young men's views toward the barriers and facilitators of internet-based chlamydia trachomatis screening: qualitative study. | there is a growing number of internet-based approaches that offer young people screening for sexually transmitted infections. | 2013 | 24300158 |
| new insights into chlamydia and arthritis. promise of a cure? | chlamydia trachomatis and chlamydia pneumoniae together comprise the most frequent causative pathogens that elicit reactive arthritis (rea). advances in our understanding of the molecular biology/molecular genetics of these organisms have improved significantly the ability to detect chlamydiae in the joint for diagnostic purposes, as well as extending our current understanding of the pathogenic processes they elicit in the joint and elsewhere. an important aspect of the latter is that synovial c ... | 2014 | 24297377 |
| a vaccine formulated with a combination of tlr-2 and tlr-9 adjuvants and the recombinant major outer membrane protein elicits a robust immune response and significant protection against a chlamydia muridarum challenge. | chlamydia trachomatis is the most common sexually transmitted bacterial pathogen in the world and there is a need for a vaccine. to enhance the immunogenicity of a vaccine formulated with the chlamydia muridarum (cm) mouse pneumonitis recombinant major outer membrane protein (momp), we used combinations of pam2csk4 + cpg-1826 and montanide isa 720 vg + cpg-1826 as adjuvants. neisseria gonorrhoeae recombinant porin b (ng-porb) was used as the antigen control with the same adjuvants. female balb/c ... | 2013 | 24291713 |
| prevalence, risk factors, and uptake of interventions for sexually transmitted infections in britain: findings from the national surveys of sexual attitudes and lifestyles (natsal). | population-based estimates of prevalence, risk distribution, and intervention uptake inform delivery of control programmes for sexually transmitted infections (stis). we undertook the third national survey of sexual attitudes and lifestyles (natsal-3) after implementation of national sexual health strategies, and describe the epidemiology of four stis in britain (england, scotland, and wales) and the uptake of interventions. | 2013 | 24286785 |
| reaching the unreachable: providing sti control services to female sex workers via mobile team outreach. | as part of a community-randomized trial of a multicomponent intervention to prevent sexually transmitted infections, we created mobile teams (mts) in ten intervention cities across peru to improve outreach to female sex workers (fsw) for strengthened sti prevention services. | 2013 | 24282565 |
| high prevalence of antibiotic-resistant mycoplasma genitalium in nongonococcal urethritis: the need for routine testing and the inadequacy of current treatment options. | empirical antibiotic therapy for nongonococcal urethritis (ngu) and cervicitis is aimed at chlamydia trachomatis, but mycoplasma genitalium, which also commonly causes undiagnosed ngu, necessitates treatment with macrolides or fluoroquinolones rather than doxycycline, the preferred chlamydia treatment. prevalence of m. genitalium and associated genotypic markers of macrolide and fluoroquinolone resistance among men symptomatic of urethritis were investigated. genetic diversity of m. genitalium p ... | 2013 | 24280088 |
| regulation of inflammatory pathways in cancer and infectious disease of the cervix. | cervical cancer is one of the leading gynaecological malignancies worldwide. it is an infectious disease of the cervix, associated with human papillomavirus infection (hpv), infection with bacterial agents such as chlamydia trachomatis and neisseria gonorrhoea as well as human immunodeficiency virus (hiv). furthermore, it is an aids-defining disease with an accelerated mortality in hiv-infected women with cervical cancer. with the introduction of robust vaccination strategies against hpv in the ... | 2012 | 24278714 |
| detection of anorectal and cervicovaginal chlamydia trachomatis infections following azithromycin treatment: prospective cohort study with multiple time-sequential measures of rrna, dna, quantitative load and symptoms. | determination of chlamydia trachomatis (ct) treatment success is hampered by current assessment methods, which involve a single post-treatment measurement only. therefore, we evaluated ct detection by applying multiple laboratory measures on time-sequential post-treatment samples. | 2013 | 24278400 |
| a case of late-stage lymphogranuloma venereum in a woman in europe. | lymphogranuloma venereum is caused by chlamydia trachomatis serovars l1-l3. the third stage of the disease leads to chronic progressive lymphangitis. the first european case of elephantiasic enlargement of the female genitalia caused by c. trachomatis l2 serovar in decades is reported. | 2013 | 24275729 |
| pelvic inflammatory disease: current concepts in pathogenesis, diagnosis and treatment. | pelvic inflammatory disease (pid) is characterized by infection and inflammation of the upper genital tract in women and can cause significant reproductive health sequelae for women. although a definitive diagnosis of pid is made by laparoscopic visualization of inflamed, purulent fallopian tubes, pid is generally a clinical diagnosis and thus represents a diagnostic challenge. therefore, diagnosis and treatment algorithms advise a high index of suspicion for pid in any woman of reproductive age ... | 2013 | 24275271 |
| zoonotic chlamydiaceae species associated with trachoma, nepal. | trachoma is the leading cause of preventable blindness. commercial assays do not discriminate among all chlamydiaceae species that might be involved in trachoma. we investigated whether a commercial micro-arraytube could discriminate chlamydiaceae species in dna extracted directly from conjunctival samples from 101 trachoma patients in nepal. to evaluate organism viability, we extracted rna, reverse transcribed it, and subjected it to quantitative real-time pcr. we found that 71 (70.3%) villager ... | 2013 | 24274654 |
| an early evaluation of clinical and economic costs and benefits of implementing point of care naat tests for chlamydia trachomatis and neisseria gonorrhoea in genitourinary medicine clinics in england. | to estimate the costs and benefits of clinical pathways incorporating a point of care (poc) nucleic acid amplification test (naat) for chlamydia and gonorrhoea in genitourinary medicine (gum) clinics compared with standard off-site laboratory testing. | 2014 | 24273127 |
| prevention and control of sexually transmissible infections among hotel-based female sex workers in dhaka, bangladesh. | hotel-based sex workers in bangladesh have high rates of sexually transmissible infections (stis), high client turnover and low condom use. two monthly clinic-based strategies were compared: periodic presumptive treatment (ppt) and enhanced syndromic management (esm) - one round of presumptive treatment followed by treatment based on assessment and laboratory tests. | 2013 | 24262217 |
| bilateral inflammation of the paraurethral glands around the external urethral orifice due to chlamydia trachomatis in a male. | 2013 | 24261726 | |
| prevalence of chlamydia trachomatis and herpes simplex virus type 2: results from the 2009 to 2011 canadian health measures survey. | chlamydia, caused by chlamydia trachomatis, and genital herpes, caused by simplex virus type 2 (hsv-2), are common sexually transmitted infections. their prevalence has been estimated in selected populations, but overall prevalence in canada is not known. | 2013 | 24258059 |
| [screening of neisseria gonorrhoeae and chlamydia trachomatis using techniques of self collected vaginal sample in young women]. | chlamydia trachomatis and neisseria gonorrhoeae are responsible for 3-10% of sexually transmitted diseases in adolescents. 75% are asymptomatic. international standards recommend annual screening for c. trachomatis in sexually active women under 26 years. self-collected vaginal swab is one of the less invasive screening methods, it is well accepted by patients and rarely used in our country. | 2013 | 24248162 |
| the il-6 response to chlamydia from primary reproductive epithelial cells is highly variable and may be involved in differential susceptibility to the immunopathological consequences of chlamydial infection. | chlamydia trachomatis infection results in reproductive damage in some women. the process and factors involved in this immunopathology are not well understood. this study aimed to investigate the role of primary human cellular responses to chlamydial stress response proteases and chlamydial infection to further identify the immune processes involved in serious disease sequelae. | 2013 | 24238294 |
| il-23 induces il-22 and il-17 production in response to chlamydia muridarum genital tract infection, but the absence of these cytokines does not influence disease pathogenesis. | chlamydia trachomatis infections are a significant cause of reproductive tract pathology. protective and pathological immune mediators must be differentiated to design a safe and effective vaccine. | 2013 | 24238108 |
| [investigation of chlamydia trachomatis seropositivity in patients with cervical cancer]. | chlamydia trachomatis is the most frequent bacterial pathogen causing sexually transmitted diseases worldwide. many studies emphasize that chlamydial infections may play role as a cofactor in cervical cancers caused by high risk human papillomavirus types. the aim of this study was to investigate the presence of antibodies specific for c.trachomatis in patients with cervical cancer in order to detect the frequency of chlamydial infections. a total of 77 patients diagnosed as cervical cancer who ... | 2013 | 24237439 |
| the role of surinamese migrants in the transmission of chlamydia trachomatis between paramaribo, suriname and amsterdam, the netherlands. | the large surinamese migrant population in the netherlands is a major risk group for urogenital chlamydia trachomatis infection. suriname, a former dutch colony, also has a high prevalence of c. trachomatis. surinamese migrants travel extensively between the netherlands and suriname. our objective was to assess whether the surinamese migrants in the netherlands form a bridge population facilitating transmission of c. trachomatis between suriname and the netherlands. if so, joint prevention campa ... | 2013 | 24236009 |
| association of anti-chlamydia antibodies with ectopic pregnancy in benin city, nigeria: a case-control study. | ectopic pregnancy remains a major public health problem especially in many developing countries where it is a significant contributor to pregnancy related morbidity and mortality. | 2013 | 24235946 |
| clinical characteristics of adenovirus associated lower respiratory tract infection in children. | acute lower respiratory tract infection (alri) due to adenovirus infection is a low frequency event but often causes severe outcome. this study was undertaken to uncover the clinical and epidemiological features of adenovirus infection in children. | 2013 | 24235068 |
| use of chlamydia trachomatis high-resolution typing: an extended case study to distinguish recurrent or persistent infection from new infection. | repeated infections of chlamydia trachomatis may be new infections or persistent infections due to treatment failure or due to unresolved infections in sexual partners. we aimed to establish the value of using high-resolution multilocus sequence typing (ct-mlst) to discriminate repeated c trachomatis infections. | 2014 | 24234071 |
| microbiological etiology of bacterial prostatitis in general hospital and primary care clinic in korea. | the national institutes of health classification of prostatitis reported the proportion of chronic bacterial prostatitis, especially category ii, at 3% to 10%. because of the polymerase chain reaction (pcr) diagnosis technique, chronic prostatitis syndrome (cps) with a known bacterial origin has increased recently. in this study, we evaluated the proportion of chronic bacterial prostatitis in a general hospital and a primary care clinic (pcc) in addition to the distribution of the microorganism ... | 2013 | 24223415 |
| bacterial vaginosis-associated bacteria in men: association of leptotrichia/sneathia spp. with nongonococcal urethritis. | approximately 45% of nongonococcal urethritis cases have no identified etiology. novel bacteria recently associated with bacterial vaginosis (bv) in women may be involved. we evaluated the association of idiopathic nongonococcal urethritis and 5 newly described bv-associated bacteria (bvab). | 2013 | 24220356 |
| [pathogens of prostatitis and their drug resistance: an epidemiological survey]. | to investigate the epidemiological features of the pathogens responsible for prostatitis in the changshu area, and offer some evidence for the clinical treatment of prostatitis. | 2013 | 24218946 |
| chlamydia trachomatis in human immunodeficiency virus-infected men treated at a referral hospital for sexually transmitted diseases in the amazonas, brazil. | the aim of the present study was to determine the chlamydia trachomatis prevalence and to identify the demographic, behavioural and clinical factors associated with c. trachomatis in human immunodeficiency virus infected men. | 2014 | 24216156 |
| bubonic lymphogranuloma venereum with multidrug treatment failure. | a patient with proctitis and inguinal buboes diagnosed with lymphogranuloma venereum (lgv) was treated with doxycycline 21 days, azithromycin 20 days and moxifloxacin for a further 12 days because of progressive worsening of inguinal symptoms. despite extensive antibiotic treatment, the inguinal lgv lesions persisted; however, the patient recovered spontaneously after three months. | 2014 | 24216037 |
| prevalence of hiv, human papillomavirus type 16 and herpes simplex virus type 2 among female sex workers in guinea and associated factors. | female sex workers are at high risk for hiv infection. sexually transmitted infections are known to be co-factors for hiv infection. our aims were (1) to assess the prevalence of hiv and other sexually transmitted infections in this population; (2) to determine the association between sociodemographic characteristics, behavioural variables, and variables related to hiv prevention and hiv infection. a cross-sectional study was conducted in conakry, guinea, among a convenience sample of 223 female ... | 2014 | 24216036 |
| chlamydia prevalence in the general population: is there a sex difference? a systematic review. | the focus of chlamydia trachomatis screening and testing lies more on women than on men. the study aim was to establish by systematic review the prevalence of urogenital chlamydia trachomatis infection in men and women in the general population. | 2013 | 24215287 |