Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| q fever endocarditis. | coxiella burnetii, the agent of q fever, produces a variety of clinical syndromes. the most frequent and serious chronic presentation is endocarditis, which presents unspecifically as a blood-culture negative endocarditis. it occurs almost exclusively in patients who have pre-existing valvular disease or who are immunocompromised. without prompt recognition and appropriate antimicrobial therapy, the course of q fever endocarditis is severe and potentially fatal. the epidemiology, signs and sympt ... | 2010 | 20218950 |
| q fever in greenland. | we report a patient with q fever endocarditis in a settlement in eastern greenland (isortoq, ammassalik area). likely animal sources include sled dogs and seals. q fever may be underdiagnosed in arctic areas but may also represent an emerging infection. | 2010 | 20202433 |
| polar localization of the coxiella burnetii type ivb secretion system. | coxiella burnetii is a gram-negative pleomorphic bacterium and the causative agent of q fever. during infection, the pathogen survives and replicates within a phagosome-like parasitophorous vacuole while influencing cellular functions throughout the host cell, indicating a capacity for effector protein secretion. analysis of the c. burnetii (rsa 493 strain) genome sequence indicates that c. burnetii contains genes with homology to the legionella pneumophila dot/icm type ivb secretion system (t4b ... | 2010 | 20199576 |
| seroprevalence of q fever in a district located in the west black sea region of turkey. | q fever is a worldwide zoonosis caused by coxiella burnetii. in turkey, it has been reported from the late 1940s that q fever is endemic in humans and animals. our objective was to evaluate the seroprevalence in samsun tekkeköy (north turkey), where an outbreak of q fever occurred in 2002. in this cross-sectional study, subjects were selected by the random proportional sampling method. all subjects were healthy with no specific symptoms and tested by the microimmunofluorescent antibody test. in ... | 2010 | 20195671 |
| review of microarray studies for host-intracellular pathogen interactions. | obligate intracellular bacteria are privileged soldiers on the battlefield that represent host-pathogen interactions. microarrays are a powerful technology that can increase our knowledge about how bacteria respond to and interact with their hosts. this review summarizes the limitations inherent to host-pathogen interaction studies and essential strategies to improve microarray investigations of intracellular bacteria. we have compiled the comparative genomic and gene expression analyses of obli ... | 2010 | 20188126 |
| [the fight against q fever. experts about the cleanup and the future of the goat husbandry in the netherlands]. | 2010 | 20178298 | |
| a dna-binding peroxiredoxin of coxiella burnetii is involved in countering oxidative stress during exponential-phase growth. | coxiella burnetii is a gram-negative, obligate intracellular bacterial pathogen that resides within the harsh, acidic confines of a lysosome-like compartment of the host cell that is termed a parasitophorous vacuole. in this study, we characterized a thiol-specific peroxidase of c. burnetii that belongs to the atypical 2-cysteine subfamily of peroxiredoxins, commonly referred to as bacterioferritin comigratory proteins (bcps). coxiella bcp was initially identified as a potential dna-binding prot ... | 2010 | 20173000 |
| [infection by coxiella burnetii (q fever)]. | in spite of being described over 60 years, q fever is still a little known disease. the exact prevalence is also unknown, but probably the number of cases of q fever is underestimated. there is much variation in the clinical presentation, including severe forms with a poor prognosis. acute cases often present as an asymptomatic infection, flu-like syndrome, pneumonia or hepatitis. presumably, host factors play an important role in the development of chronic disease, which may present as endocard ... | 2010 | 20172420 |
| european homograft bank: twenty years of cardiovascular tissue banking and collaboration with transplant coordination in europe. | established in 1989 in brussels as an international nonprofit association, the european homograft bank (ehb) has been collaborating closely with the transplant coordination of the different centers in belgium and other european countries. donor selection is made after discussion of exclusion criteria with the transplant coordinator of the procurement center. ehb collaborates with 15 belgian, 11 german, 10 french, 10 swiss, 3 italian, 3 dutch, and some other procurement and/or implantation center ... | 2010 | 20172310 |
| q fever pneumonia. | q fever is a disease found in both humans and animals, caused by the bacterium coxiella burnetii. the epidemiology of q fever is that of the animal reservoirs of the infection including both direct and indirect contact and use of a variety of products from such animals as cattle, sheep, and goats. pneumonia is the major manifestation of q fever in some countries. it is mild to moderate in severity, and mortality is unusual. it can occur as sporadic or outbreak cases. | 2010 | 20171543 |
| considering q fever when working with laboratory sheep. | the sheep (ovis aries) is somewhat less common than smaller species in laboratory settings, but personnel who work with sheep or in a facility that houses sheep should be aware that certain zoonotic diseases are common in sheep. they should also know how to prevent transmission of zoonotic disease in facilities that house or work with small ruminants. knowledge of diseases such as query fever (q fever), which can cause severe human morbidity (and in some cases death), needs to be especially emph ... | 2010 | 20164950 |
| peri- and intra-operative management of the goat during acute surgical experimentation. | goats are used as animal models for surgery and trauma research. the authors discuss appropriate methods for induction of anesthetics, intubation and surgical maintenance of the goat during acute experimentation. risks imposed by the q fever pathogen coxiella burnetii are described, as well as measures that have proven effective in minimizing zoonotic transmission of this pathogen to laboratory personnel. with appropriate knowledge of its applications, peri- and intra-operative management and li ... | 2010 | 20164949 |
| the changing etiology of fever of intermediate duration. | fever of intermediate duration (fid) is a common condition. currently, its most frequent causes are not well defined. | 2010 | 20153558 |
| a q fever outbreak in a psychiatric care institution in the netherlands. | in may 2008 the nijmegen municipal health service (mhs) was informed about an outbreak of atypical pneumonia in three in-patients of a long-term psychiatric institution. the patients had been hospitalized and had laboratory confirmation of acute q fever infection. the mhs started active case finding among in-patients, employees of and visitors to the institution. in a small meadow on the institution premises a flock of sheep was present. one of the lambs in the flock had been abandoned by its mo ... | 2011 | 20141644 |
| microbiological quality of milk from small processing units in senegal. | consumption of milk and dairy products has increased significantly in senegal in the last decade, and a large part of the local production comes from small processing units spread all over the country. we collected 85 bulk-tank milk samples from 68 smallholder dairy farms throughout the territory. microbiological quality of milk samples was analyzed according to the official standards. further, raw milk and pasteurized milk were screened for mycobacterium bovis, coxiella burnetii, and anti-bruce ... | 2010 | 20141346 |
| q fever: underdiagnosed in hong kong? | we report the first imported case of chronic q fever with multi-organ involvement seen in hong kong. although the disease is found worldwide, its chronic form is very rare in our locality. familiarity with the clinical presentation, useful diagnostic tools, and appropriate treatment is necessary for the prevention of the serious morbidity and mortality associated with chronic q fever. to the best of our knowledge, this article represents the first comprehensive review to compare the local experi ... | 2010 | 20124575 |
| [results of examination of healthy residents in the southern region of russia and patients feverish to pappataci fever virus antibodies]. | sera from patients with acute seasonal fevers and apparently healthy individuals living in the astrakhan region, krasnodar territory, or rostov region were examined in two modifications of enzyme immunoassay for detection of igm and igg antibodies to neapolitan and sicilian pappataci fever viruses. igm antibodies to sicilian pappataci fever virus were detected in a patient from the volodarsky district, astrakhan region, who had been admitted for the unverified diagnosis of q fever. a donor resid ... | 2009 | 20120368 |
| infectious complications in oif/oef veterans with traumatic brain injury. | of veterans from the u.s. global war on terrorism who have sought care in the department of veterans affairs, approximately 12% have an infectious disease diagnosis. infections in those veterans with traumatic brain injury (tbi) include infections associated with blast injuries and burns, such as skin and soft tissue infections; infections as a result of retained bullet or shrapnel fragments; pulmonary infections resulting from lung injury, intubation, or resultant tracheostomy; hospital-acquire ... | 2009 | 20104397 |
| [doxycycline]. | doxycycline is a semi-synthetic derivative of tetracycline family exhibiting an interesting pharmacokinetic profile since no dosage adjustment is required for renal failure. doxycycline displays good bacteriostatic activity against most bacteria as well as anti-inflammatory activity. bacterial resistance is mainly acquired. many infectious diseases can be treated with doxycycline including brucellosis, pasteurellosis, borreliosis, rickettsioses, trepanomatosis, cholera, leptospirosis, q fever, p ... | 2009 | 20099667 |
| serological patterns of brucellosis, leptospirosis and q fever in bos indicus cattle in cameroon. | brucellosis, leptospirosis and q fever are important infections of livestock causing a range of clinical conditions including abortions and reduced fertility. in addition, they are all important zoonotic infections infecting those who work with livestock and those who consume livestock related products such as milk, producing non-specific symptoms including fever, that are often misdiagnosed and that can lead to severe chronic disease. this study used banked sera from the adamawa region of camer ... | 2010 | 20098670 |
| epstein-barr virus infection associated with bone marrow fibrin-ring granuloma. | we previously reported 24 cases of marrow fibrin-ring granuloma (frg) encountered in 1 institution and concluded that, contrary to previous studies showing marrow frg as a diagnostic marker for q fever, epstein-barr virus (ebv) was the most common proven cause of such frg. the present study characterized patients with ebv-associated marrow frg. we retrospectively reviewed 17 cases of ebv-associated frg (43% of 40 cases with marrow frg) diagnosed by bone marrow biopsy. patients with ebv-associate ... | 2010 | 20093240 |
| prevalence of coxiella burnetii antibodies in danish dairy herds. | during recent years in denmark higher rates of antibodies to coxiella burnetii have been detected in animals and humans than previously reported. a study based on bulk tank milk samples from 100 randomly selected dairy herds was performed to estimate the prevalence and geographical distribution of antibody positive dairy herds. using the chekit q-fever antibody elisa test kit (idexx), the study demonstrated a prevalence of 59% antibody positive herds, 11% antibody intermediate herds and 30% anti ... | 2010 | 20092653 |
| seroepidemiological study of q fever in domestic ruminants in semi-extensive grazing systems. | q fever, a worldwide zoonotic disease caused by coxiella burnetii, is endemic in northern spain where it has been reported as responsible for large series of human pneumonia cases and domestic ruminants' reproductive disorders. to investigate pathogen exposure among domestic ruminants in semi-extensive grazing systems in northern spain, a serosurvey was carried out in 1,379 sheep (42 flocks), 626 beef cattle (46 herds) and 115 goats (11 herds). serum antibodies were analysed by elisa and positiv ... | 2010 | 20089188 |
| infectious diseases. questions abound in q-fever explosion in the netherlands. | 2010 | 20075230 | |
| development of a novel dna microarray to detect bacterial pathogens in patients with chronic obstructive pulmonary disease (copd). | a novel microarray was constructed with dna pcr product probes targeting species specific functional genes of nine clinically significant respiratory pathogens, including the gram-positive organisms (streptococcus pneumoniae, streptococcus pyogenes), the gram-negative organisms (chlamydia pneumoniae, coxiella burnetii haemophilus spp., legionella pneumophila, moraxella catarrhalis, and pseudomonas aeruginosa), as well as the atypical bacterium, mycoplasma pneumoniae. in a "proof-of-concept" eval ... | 2010 | 20074591 |
| fibrin ring granulomas in rickettsia typhi infection. | we describe a 71-year-old man hospitalized for fever and productive cough. laboratory investigation showed anemia, thrombocytopenia, elevated transaminases, hyponatremia, and hypoalbuminemia. computerized tomography of the abdomen, thorax, and sinuses, echocardiography, and a gallium scan did not reveal the source of the fever. the patient remained febrile despite courses of piperacillin-tazobactam/azithromycin and ceftriaxone/vancomycin. a bone marrow biopsy showed fibrin ring granulomas, and 2 ... | 2010 | 20071129 |
| prevalence of coxiella burnetii antibodies in wild ruminants in kavecany zoo, kosice, eastern slovakia. | coxiella burnetii is an obligate intracellular agent that causes q fever in humans and animals. the most important reservoirs of c. burnetii in nature are small wild rodents, but infection was also demonstrated in other animals, including ruminants. samples of blood were obtained from 4 mouflons, 60 fallow deer, 9 cameroun goats, 8 carpathian goats, and 8 cameroun sheep living in a zoo. antibodies to phase i and phase ii c. burnetii antigens were determined in sera by elisa. antibody titres were ... | 2009 | 20055359 |
| prevalence of coxiella burneti antibodies in wild ruminants in kaveeany zoo, kosice, eastern slovakia. | coxiella burnetii is an obligate intracellular agent that causes q fever in humans and animals. the most important reservoirs of c. burnetii in nature are small wild rodents, but infection was also demonstrated in other animals, including ruminants. samples of blood were obtained from 4 mouflons, 60 fallow deer, 9 cameroun goats, 8 carpathian goats, and 8 cameroun sheep living in a zoo. antibodies to phase i and phase ii c. burnetii antigens were determined in sera by elisa. antibody titres were ... | 2009 | 20054886 |
| seroprevalence of q fever, brucellosis and leptospirosis in farmers and agricultural workers in bari, southern italy. | to establish the seroprevalence of antibodies to c. burnetii, leptospira and brucella in subjects at risk of exposure, 128 workers exposed to farm animals and 280 healthy blood donors were studied. antibodies to c. burnetii, leptospira and brucella were determined by indirect immunofluorescence assay, by microagglutination test (mat) and by standard tube agglutination test, respectively. of subjects exposed to farm animals 73.4 % were positive for anti c. burnetii igg (titer > or = 20) compared ... | 2009 | 20047252 |
| proteomic screening for possible effector molecules secreted by the obligate intracellular pathogen coxiella burnetii. | coxiella burnetii is a gram-negative, gamma-proteobacteria with nearly worldwide distribution, and it is the pathogenic agent of q-fever in man. it is an obligate intracellular parasite that is highly adapted to reside within the eukaryotic phagolysosome. in fact, it is the only known intracellular bacterium that manages to survive and replicate within a fully formed, acidic phagolysosome. c. burnetti possesses a functional type 4 secretion system (t4ss), similar to the dot/icm system of legione ... | 2010 | 20044831 |
| mycotic splenic artery aneurysm secondary to coxiella burnetii endocarditis. | mycotic artery aneurysms are rare but potentially lethal vascular lesions due to their high risk of rupture. bacterial endocarditis as well as trauma and inadequate immunity are predisposing factors. surgery remains the treatment of choice, although alternative methods have been used. we report the first known case of a 6 cm mycotic splenic artery aneurysm proximal to the splenic hilum, secondary to bacterial endocarditis from coxiella burnetii. resection of the aneurysm, splenectomy, and distal ... | 2010 | 20036491 |
| a survey of western australian sheep, cattle and kangaroos to determine the prevalence of coxiella burnetii. | the objective of this study was to investigate the prevalence of coxiella burnetii in two domestic ruminant species (cattle and sheep) and the western grey kangaroo (macropus fuliginosus) in western australia (wa). the idexx chekit q fever elisa and cft were used to test sera from 50 sheep and 329 head of cattle for anti-c. burnetii antibodies and 343 kangaroo sera were tested using an indirect elisa developed specifically for this study. faecal or urine samples collected from the same animals w ... | 2010 | 20036083 |
| real-time pcr with serum samples is indispensable for early diagnosis of acute q fever. | the world's largest q fever outbreak is ongoing in the netherlands with around 3,000 confirmed cases since the first half of 2007. increased awareness has resulted in early referral of patients for diagnostics. an important drawback to serological diagnosis of acute q fever is the lag phase in antibody response. therefore, we evaluated the performance of a real-time pcr for detection of coxiella burnetii dna using serum samples from patients with acute q fever. pcr, targeting is1111, was retrosp ... | 2010 | 20032219 |
| beclin 1 modulates the anti-apoptotic activity of bcl-2: insights from a pathogen infection system. | coxiella burnetii is an obligate intracellular bacterium that generates large vacuoles in which this pathogen replicates and survives. we have previously demonstrated that c. burnetii interacts with the autophagic pathway as a strategy for its survival and replication. coxiella displays an anti-apoptotic activity to maintain host cell viability, leading to a persistent infection. our recent study reveals that beclin 1 is recruited to the coxiella-membrane vacuole favoring its development and bac ... | 2010 | 20023428 |
| a case of person-to-person transmission of q fever from an active duty serviceman to his spouse. | coxiella burnetii has recently gained military relevance given its potential as a bioterrorism agent, and the multiple cases reported among u.s. military personnel deployed to the middle east. sexual transmission of q fever is rare but has been reported in the literature. we describe the possible sexual transmission of q fever from a returning serviceman from iraq to his wife. in a recent editorial commentary, dr. raoult wrote about the reemergence of q fever after september 11, 2001 (raoult 200 ... | 2010 | 20020811 |
| [pandora's box: pathogens in ixodes ricinus ticks in central europe]. | among the various species of hard ticks, ixodes ricinus is the most frequently found tick throughout europe. as with other ixodid ticks, the developmental cycle runs through three stages. in each stage a blood meal is required in order to develop to the next stage. ixodes ricinus has been found to feed on more than 300 different vertebrate species. usually, larval ticks feed on small mammals such as mice and become infected with various microorganisms and viruses, of which some are substantial p ... | 2009 | 19998007 |
| seroprevalence of neospora caninum antibodies and its consequences for reproductive parameters in dairy cows from dakar-senegal, west africa. | the aim of this study was to determine the seroprevalence of neospora caninum antibodies and its effects on reproductive parameters in cows in intensive dairy herds in dakar. randomised blood samples were taken for serology from 196 cows in four herds with a history of sporadic abortion. all of the sera were assayed for antibodies against n. caninum, candida guillermondii, coxiella burnetii, and chlamydophila sp. the associations between serostatus and reproductive parameters (abortion, number o ... | 2010 | 19997972 |
| detection of coxiella burnetii by nested pcr in bulk milk samples from dairy bovine, ovine, and caprine herds in iran. | the epidemiology of q-fever in iran is essentially unknown. this study was conducted to determine the prevalence rate of coxiella burnetii in bulk milk samples from dairy bovine, ovine, and caprine herds in chaharmahal va bakhtiari province, iran. in this study, 376 bulk milk samples from 79 dairy bovine, ovine, and caprine herds were tested for c. burnetii using a nested pcr assay. the animals whose milk samples collected for this study were clinically healthy. in total, 13 of 210 (6.2%) bovine ... | 2010 | 19968851 |
| identification of risk factors of coxiella burnetii (q fever) infection in veterinary-associated populations in southern taiwan. | the first case of q fever in taiwan was reported in 1993. the disease is considered to be emerging in taiwan, but the route of transmission has remained unclear. the annual number of confirmed q fever cases has been increasing up to more than 100 cases since 2005, comparing with less than 30 before 2003. the purpose of this study was to determine the seroprevalence and risk factors of coxiella burnetii infection in veterinary-associated populations in southern taiwan. a total of 228 serum sample ... | 2010 | 19968850 |
| dual high titer antineutrophil cytoplasmic autoantibodies in association with systemic q fever. | 2009 | 19956002 | |
| microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis. | the authors have previously reported genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis (cfs/me) based on expression of 88 human genes. | 2010 | 19955554 |
| c. pneumoniae community-acquired pneumonia (cap) in mimicking mycoplasma pneumoniae meningoencephalitis complicated by asthma. | chlamydophila (chlamydia) pneumoniae is a common, non-zoonotic cause of community-acquired pneumonia (cap) in ambulatory young adults. c. pneumoniae clinically presents as a mycoplasma-like illness frequently accompanied by laryngitis. c. pneumoniae cap may also cause nursing home outbreaks in the elderly. similar to mycoplasma pneumoniae in immunocompetent hosts, c. pneumoniae cap usually manifests as a mild/moderately severe cap. in contrast with legionnaire's disease, central nervous system i ... | 2009 | 19944878 |
| dengue fever scoring system: new strategy for the early detection of acute dengue virus infection in taiwan. | dengue fever is an important public health problem in southern taiwan. the purpose of this study was to develop a dengue scoring system using a three-stage process, which may be used as a guidance tool for the early diagnosis of dengue fever. | 2009 | 19933032 |
| tricuspid and aortic valve and ventricular septal defect endocarditis: an unusual presentation of acute q fever. | q fever is a rare systemic infection caused by coxiella burnetii. the presentation with endocarditis is insidious, with negative blood cultures, and oftentimes it is not obvious in diagnostic imaging studies until hemodynamic changes or valve destruction is reached. we report a case of q fever endocarditis involving the tricuspid and aortic valves and a congenital ventricular septal defect. surgical treatment and distinct aspects of this unusual case are herein described. | 2009 | 19932290 |
| investigation of a q fever outbreak in a scottish co-located slaughterhouse and cutting plant. | outbreaks of q fever are rare in the uk. in 2006, the largest outbreak of q fever in scotland occurred at a co-located slaughterhouse and cutting plant with 110 cases. preliminary investigations pointed to the sheep lairage being the potential source of exposure to the infective agent. a retrospective cohort study was carried out among workers along with environmental sampling to guide public health interventions. a total of 179 individuals were interviewed of whom 66 (37%) were migrant workers. ... | 2010 | 19912614 |
| multicenter geosentinel analysis of rickettsial diseases in international travelers, 1996-2008. | we investigated epidemiologic and clinical aspects of rickettsial diseases in 280 international travelers reported to the geosentinel surveillance network during 1996-2008. of these 280 travelers, 231 (82.5%) had spotted fever (sfg) rickettsiosis, 16 (5.7%) scrub typhus, 11 (3.9%) q fever, 10 (3.6%) typhus group (tg) rickettsiosis, 7 (2.5%) bartonellosis, 4 (1.4%) indeterminable sfg/tg rickettsiosis, and 1 (0.4%) human granulocytic anaplasmosis. one hundred ninety-seven (87.6%) sfg rickettsiosis ... | 2009 | 19891867 |
| [many questions about q fever left]. | 2009 | 19891342 | |
| [erythema nodosum secondary to q fever]. | 2009 | 19889328 | |
| laboratory maintenance of coxiella burnetii. | coxiella burnetii, an obligate intracellular gram-negative bacterium, is the agent of q fever, a self-limited flu-like illness that may also present as chronic endocarditis. the ability to persist in the environment at a low infectious dose in aerosols resulted in the classification of c. burnetii as a bsl-3 select agent. routine propagation of this agent is in embryonated eggs or tissue culture. purification from host tissues includes multiple differential centrifugations to separate bacteria f ... | 2009 | 19885942 |
| q fever. | q fever is a zoonotic disease caused by the ubiquitous pathogen coxiella burnetii responsible for acute and chronic clinical manifestations. farm animals and pets are the main reservoirs of infection, and transmission to human beings is mainly accomplished through inhalation of contaminated aerosols. this illness is associated with a wide clinical spectrum, from asymptomatic or mildly symptomatic seroconversion to fatal disease. in humans q fever can manifest as an acute disease (mainly as a sel ... | 2010 | 19875249 |
| morphological structure of rickettsiae. | the morphological structures of the rickettsiae of epidemic and endemic typhus fever, rocky mountain spotted fever, and q fever are similar to one another and to certain bacteria. the rickettsial organisms in common with the elementary bodies of vaccinia virus and all bacteria would appear to have a limiting membrane which surrounds a substance that seems to be protoplasmic in nature; numbers of dense granules are embedded in the inner protoplasm. | 1943 | 19871289 |
| acute q fever and scrub typhus, southern taiwan. | acute q fever and scrub typhus are zoonoses endemic to southern taiwan. among the 137 patients with acute q fever (89, 65.0%) or scrub typhus (43, 31.4%), we identified 5 patients (3.6%) who were co-infected with coxiella burnetii and orientia tsutsugamushi. | 2009 | 19861068 |
| bone marrow involvement in q fever--detection by fluorine-18-labelled fluorodeoxyglucose pet. | 2009 | 19850230 | |
| emerging evidence for q fever in humans in denmark: role of contact with dairy cattle. | until recently, q fever was notified in very low numbers annually in denmark and it was always considered to be acquired abroad. preliminary reports now describe coxiella burnetii in milk samples from danish dairy cattle. serum samples of a large cohort of farmers, veterinarians, inseminators and hoof trimmers, all having occupational contact with dairy cattle, were tested for the presence of igg to phase i and phase ii antigens of c. burnetii. in 39 of 359 individuals studied (11%), the presenc ... | 2010 | 19832723 |
| coxiella burnetii as a possible cause of autoimmune liver disease: a case report. | q fever is a zoonotic infection that may cause severe hepatitis. q-fever hepatitis has not yet been associated with autoimmune hepatitis and/or primary biliary cirrhosis. | 2009 | 19830243 |
| [severe cholestatic hepatitis due to q fever: report of a case]. | severe cholestatic hepatitis due to coxiella burnetii is a rare form of clinical presentation of acute q fever that is only occasionally detected in association with this infectious disease. we report a case of severe cholestatic hepatitis due to acute q fever, with clinical signs of hepatic insufficiency, marked cholestasis, and renal insufficiency. the results of the initial serologic study using a complement fixation test were negative on two occasions, and transjugular biopsy and serological ... | 2010 | 19819043 |
| seroprevalence of q fever in the united states, 2003-2004. | we performed serum testing for igg antibodies against coxiella burnetii (phase i and phase ii) and analyzed questionnaire data from 4,437 adults > or = 20 years of age who participated in the national health and nutrition examination survey 2003-2004 survey cycle. national q fever seroprevalence was determined by enzyme-linked immunosorbent assay and confirmed by using immunofluorescent antibody testing. overall seroprevalence for coxiella burnetii was 3.1% (95% confidence interval [ci] = 2.1-4. ... | 2009 | 19815888 |
| [family outbreak of q fever]. | 2010 | 19811857 | |
| comparison of the q-fever complement fixation test and two commercial enzyme-linked immunosorbent assays for the detection of serum antibodies against coxiella burnetti (q-fever) in ruminants : recommendations for use of serological tests on imported animals in new zealand. | to make valid recommendations on the use of serological test methods for the detection of serum antibodies in ruminants against coxiella burnetii (q-fever), by comparing the performance of the complement fixation test (cft) and two elisa, and by identifying reasons for discrepancies between the test methods. | 2009 | 19802039 |
| coxiella burnetii modulates beclin 1 and bcl-2, preventing host cell apoptosis to generate a persistent bacterial infection. | coxiella burnetii is the etiological agent of the human disease, q fever, and is an obligate intracellular bacterium that invades and multiplies in a vacuole with lysosomal characteristics. we have previously shown that coxiella interacts with the autophagic pathway as a strategy for its survival and replication. in addition, recent studies have shown that coxiella exerts anti-apoptotic activity to maintain the host cell viability, thus generating a persistent infection. in the present report, w ... | 2010 | 19798108 |
| seroprevalence of q-fever, brucellosis and leptospirosis in farmers and agricultural workers in bari, southern italy. | 2009 | 19793130 | |
| prevalence of coxiella burnetii and bartonella species as cases of infective endocarditis in marseilles (1994-2007). | 2009 | 19793124 | |
| seroprevalence of q-fever in algeria. | 2009 | 19793121 | |
| efficiency of a phase 1 vaccine for the reduction of vaginal coxiella burnetii shedding in a clinically affected goat herd. | 2009 | 19793119 | |
| coxiella burnetii isolates cause genogroup-specific virulence in mouse and guinea pig models of acute q fever. | q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium coxiella burnetii. humans with q fever may experience an acute flu-like illness and pneumonia and/or chronic hepatitis or endocarditis. various markers demonstrate significant phylogenetic separation between and clustering among isolates from acute and chronic human disease. the clinical and pathological responses to infection with phase i c. burnetii isolates from the following four genomic gr ... | 2009 | 19786560 |
| markers of infection in inpatients and outpatients with acute q-fever. | query-fever (q-fever) is a zoonotic infection caused by the intracellular gram-negative coccobacillus coxiella burnetii. a large ongoing outbreak of q-fever has been reported in the netherlands. we studied various markers of infection in inpatients (hospitalised) and outpatients (treated by a general physician) with acute q-fever in relation to disease severity. | 2009 | 19778289 |
| inducible bronchus-associated lymphoid tissue elicited by a protein cage nanoparticle enhances protection in mice against diverse respiratory viruses. | destruction of the architectural and subsequently the functional integrity of the lung following pulmonary viral infections is attributable to both the extent of pathogen replication and to the host-generated inflammation associated with the recruitment of immune responses. the presence of antigenically disparate pulmonary viruses and the emergence of novel viruses assures the recurrence of lung damage with infection and resolution of each primary viral infection. thus, there is a need to develo ... | 2009 | 19774076 |
| difficulties in the diagnosis and management of a us servicemember presenting with possible chronic q fever. | a 34 year old corpsman developed acute q fever upon return from iraq. subsequent testing demonstrated trace mitral regurgitation and widely discrepant serologic testing results between commercial and reference laboratories. we discuss the dilemma of isolated minor echocardiographic abnormalities and propose caution in the interpretation of q fever serologic tests. | 2010 | 19766138 |
| mycoplasma pneumoniae community-acquired pneumonia (cap) in the elderly: diagnostic significance of acute thrombocytosis. | the most common cause of nonzoonotic atypical community-acquired pneumonia (cap) is mycoplasma pneumoniae. m. pneumoniae cap is most common in young adults but may occur at any age. like other atypical caps, m. pneumoniae is associated with a characteristic pattern of extrapulmonary organ involvement and nonspecific laboratory tests. m. pneumoniae cap is frequently accompanied by gastrointestinal manifestations (eg, loose stools/diarrhea), nonexudative pharyngitis, or skin involvement (ie, eryth ... | 2009 | 19755196 |
| histopathology of a granulomatous lobular panniculitis in acute q fever: a case report. | q fever is a zoonotic infection caused by coxiella burnetii. two forms of the disease have been described: an acute form with pneumonia, hepatitis or a flu-like syndrome; and a chronic form in which endocarditis is the most frequent clinical expression. we report a 77 year old male with fever and an erythematous nodule on the right leg. biopsy revealed a granulomatous lobular panniculitis with some granulomas rimmed by an eosinophilic material, giving a "doughnut" or "fibrin-ring" appearance. q ... | 2010 | 19751228 |
| determination of new cutoff values for indirect immunofluorescence antibody test for q fever diagnosis in denmark. | q fever is a ubiquitous zoonosis caused by coxiella burnetii. the disease is emerging in many parts of the world, likely because of increased awareness and availability of better diagnostics. the diagnosis is primarily based on serology. because the prevalence of the disease varies worldwide, the establishment of local cutoff values is needed. a baseline for antibodies against c. burnetii in denmark was defined by testing sera from healthy danish volunteers using a commercially available immunof ... | 2009 | 19748417 |
| central nervous system manifestations of q fever responsive to steroids. | we report the clinical and radiological central nervous system manifestations of a 27-year-old man with q fever who subsequently developed acute disseminated encephalomyelitis and showed a significant response to steroids. the patient presented with headache and fever and quickly progressed to develop acute respiratory failure and hepatitis. a prompt evaluation revealed positive serology for q fever and doxycycline was initiated. approximately 1 week into his illness he was noted to be profoundl ... | 2009 | 19743743 |
| [detection of tick and tick-borne pathogen in some ports of inner mongolia]. | to investigate the distribution, composition and situation of natural infection pathogen of tick species in the main ports of inner mongolia. | 2009 | 19731529 |
| q fever cholecystitis in an unvaccinated butcher diagnosed by gallbladder polymerase chain reaction. | acalculous cholecystitis has been described in association with q fever. we describe the first known case of q fever cholecystitis diagnosed by polymerase chain reaction on gallbladder tissue. the presence of coxiella burnetii genome in the diseased gallbladder tissue argues for direct involvement of the organism in the pathogenesis of q fever cholecystitis. | 2010 | 19725764 |
| [vaccination: q fever is treated at the source]. | 2009 | 19697681 | |
| [serological diagnosis of q fever: a pending matter?]. | 2010 | 19683316 | |
| diagnosis of placental pathogens in small ruminants by immunohistochemistry and pcr on paraffin-embedded samples. | a histological study was carried out on 58 formalin-fixed and paraffin-embedded samples of placenta from sheep and goats that had aborted, and the placental lesions were graded. sequential histological sections of each cotyledon were then immunostained with specific antibodies and used for pcr detection of chlamydophila abortus, coxiella burnetii, salmonella abortusovis, brucella melitensis, listeria monocytogenes and toxoplasma gondii. most of the cotyledons showed different degrees of placenti ... | 2009 | 19666916 |
| acute q fever in pregnancy: report and literature review. | acute q fever in pregnancy is uncommon, but is probably underrecognized. it results in a significant risk of adverse pregnancy outcome and also predisposes to the development of chronic q fever in the mother. here, we review the clinical features, epidemiology, treatment and follow-up of acute q fever in pregnancy. the potential for transmission of coxiella to the neonate and birthing suite staff will also be highlighted. | 2009 | 19664158 |
| azithromycin for acute q fever in pregnancy. | q fever is a zoonosis caused by coxiella burnetii. although data on q fever during pregnancy are limited, they indicate that infection with c. burnetii is associated with high morbidity and mortality. the infection is usually asymptomatic in pregnant women but may result in obstetric complications such as spontaneous abortion, intrauterine growth retardation, intrauterine fetal death and premature delivery; in addition, pregnant women are at higher risk of developing chronic q fever. treatment o ... | 2009 | 19657611 |
| new approaches to detection and identification of rickettsia africae and ehrlichia ruminantium in amblyomma variegatum (acari: ixodidae) ticks from the caribbean. | imported from africa in the 1700s and despite frequent modern eradication efforts, amblyomma variegatum (f.) spread through the caribbean by cattle transport, small ruminants, and migrating birds. a. variegatum is a vector for rickettsia africae, the causative agent of african tick bite fever, and ehrlichia ruminantium, the causative agent of heartwater. we examined 95 a. variegatum and six rhipicephalus (boophilus) microplus (canestrini) collected from cattle at an abattoir in antigua. engorged ... | 2009 | 19645301 |
| actin dynamics and rho gtpases regulate the size and formation of parasitophorous vacuoles containing coxiella burnetii. | q fever is a disease caused by coxiella burnetii. in the host cell, this pathogen generates a large parasitophorous vacuole (pv) with lysosomal characteristics. here we show that f-actin not only is recruited to but also is involved in the formation of the typical pv. treatment of infected cells with f-actin-depolymerizing agents alters pv development. the small pvs formed in latrunculin b-treated cells were loaded with transferrin and lysotracker and labeled with an antibody against cathepsin d ... | 2009 | 19635823 |
| a case of q fever. | 2009 | 19626527 | |
| enhanced q fever risk exposure surveillance may permit better informed vaccination policy. | the association between farming risks and q fever is not well documented in australia. in a review of new south wales notifications, data were analysed using 3-year study periods from 1993 to 2007 to investigate possible trends and explore reported risk exposures. a retrospective case series was also conducted using acute q fever cases notified during 2007 from a rural area of new south wales. occupation was recorded for less than 50% of q fever notifications in new south wales during the study ... | 2009 | 19618770 |
| severe q fever community-acquired pneumonia (cap) mimicking legionnaires' disease: clinical significance of cold agglutinins, anti-smooth muscle antibodies and thrombocytosis. | atypical community-acquired pneumonia (cap) may be caused by zoonotic or nonpulmonary pathogens. however, atypical pathogens are systemic infectious disease accompanied by pneumonia in contrast with typical bacterial pathogens with infection limited to the lungs and absent extrapulmonary findings. clinically and radiologically, the atypical cap pathogens that most closely resemble each other are psittacosis, q fever, and legionnaires' disease. psittacosis can usually be readily suspected or elim ... | 2009 | 19577708 |
| [mycotic aneurysm of infrarenal abdominal aorta due to coxiella burnetii]. | 2010 | 19573882 | |
| simultaneous differential detection of chlamydophila abortus, chlamydophila pecorum and coxiella burnetii from aborted ruminant's clinical samples using multiplex pcr. | chlamydiosis and q fever, two zoonosis, are important causes of ruminants' abortion around the world. they are caused respectively by strictly intracellular and gram negative bacterium chlamydophila abortus (cp. abortus) and coxiella burnetii (c. burnetii). chlamydophila pecorum (cp. pecorum) is commonly isolated from the digestive tract of clinically inconspicuous ruminants but the abortive and zoonotic impact of this bacterium is still unknown because cp. pecorum is rarely suspected in abortio ... | 2009 | 19570194 |
| an outbreak of q fever in bulgaria. | q fever is an acute febrile illness due to coxiella burnetii. in the balkans, q fever in humans has been reported since world war ii, and in countries such as bulgaria the number of cases has increased since the early 1990s. we report an investigation of an outbreak in the town of botevgrad, western bulgaria. overall, 220 cases were identified between may 1 and june 9, 2004. of the cases, 168 were from botevgrad; the others were from neighbouring towns. this has been the largest outbreak in bulg ... | 2009 | 19567983 |
| etiology of acute undifferentiated febrile illness in the amazon basin of ecuador. | we conducted a longitudinal observational study of 533 patients presenting to two hospitals in the ecuadorean amazon basin with acute undifferentiated febrile illness (aufi) from 2001 through 2004. viral isolation, reverse transcription-polymerase chain reaction (rt-pcr), igm seroconversion, and malaria smears identified pathogens responsible for fever in 122 (40.1%) of 304 patients who provided both acute and convalescent blood samples. leptospirosis was found in 40 (13.2%), malaria in 38 (12.5 ... | 2009 | 19556580 |
| q fever: persistence of antigenic non-viable cell residues of coxiella burnetii in the host--implications for post q fever infection fatigue syndrome and other chronic sequelae. | our previous studies of persistence of coxiella burnetii in humans after an initial acute q fever infection revealed raised, maintained antibody levels and low levels of coxiella genomic dna at the age of 5 years from onset in australian patients and at 12 years in patients in the 1989 birmingham uk q fever outbreak. attempts to isolate the coxiella in standard cell culture and susceptible mice by serial passage of pcr positive pbmc and bone marrow were negative. | 2009 | 19556396 |
| duplex pcr assay simultaneously detecting and differentiating bartonella quintana, b. henselae, and coxiella burnetii in surgical heart valve specimens. | a duplex pcr (dpcr) assay was developed to simultaneously detect and differentiate bartonella quintana, bartonella henselae, and coxiella burnetii from surgical heart valve tissue specimens with an analytic sensitivity of 10 copies/reaction. among 17 specimens collected from patients with a clinical diagnosis of culture-negative endocarditis, 2, 4, and 2 were positive for b. quintana, b. henselae, and c. burnetii, respectively, by the dpcr assay, which matched the results obtained by universal b ... | 2009 | 19553582 |
| immunohistochemical detection of coxiella burnetii in chronic q fever hepatitis. | 2009 | 19548997 | |
| immunohistochemical detection of coxiella burnetii in an aortic graft. | 2009 | 19548996 | |
| diagnosis of coxiella burnetii pericarditis by using a systematic prescription kit in cases of pericardial effusion: an 8-year experience. | 2009 | 19548995 | |
| coinfection with coxiella burnetii in infectious endocarditis. | 2009 | 19548994 | |
| role of the cytoplasmic pattern recognition receptor nod2 in coxiella burnetii infection. | 2009 | 19548991 | |
| rickettsioses in australia. | the rickettsial diseases of australia are described in their chronological order of discovery. the include epidemic typhus (r. prowazekii); murine typhus (r. typhi) found australia-wide; scrub typhus (o. tsutsugamushi) only in tropical, northen australia; q. fever (c. burnetti) found australia-wide; queensland tick typhus (r. australis) along the east coast of australia; flinders island spotted fever (r. honei) in southeast australia; variant flinders island spotted fever (r. honei, strain "marm ... | 2009 | 19538275 |
| q fever in dairy animals. | this review evaluates the threat to human health--with the shedding of c. burnetii in dairy animals with reproductive disorders or those without clinical signs. the review also discusses the diagnosis of q fever in livestock and the possibility of coxiella-free herds, and it reports the available methods for controlling q fever. c. burnetii shedding seems to occur frequently in milk taken from asymptomatic dairy cows. the number of coxiella shed in milk is generally low. the phase i vaccine prev ... | 2009 | 19538267 |
| q fever during pregnancy: a cause of poor fetal and maternal outcome. | q fever is a worldwide zoonosis caused by coxiella burnetii. q fever may be present as an acute or a chronic infection and can be reactivated during subsequent pregnancies. although its exact prevalence remains unknown, it is likely that the number of cases of q fever in pregnant women is underestimated. during pregnancy, the illness is likely to be asymptomatic, and diagnosis is based on serology. acute infection results in appearance of igm and igg antibodies mainly directed against the avirul ... | 2009 | 19538266 |
| coxiella burnetii glycomics and proteomics--tools for linking structure to function. | coxiella burnetii, the causative agent of q fever, is an obligate intracellular bacterium and a highly infectious pathogen. the disease is a widespread zoonosis and is endemic throughout the world. an easy aerosol dissemination, environmental persistence, and high infectivity make the bacterium a serious threat for humans and animals. lipopolysaccharide is considered one of the major factors of virulence expression and infection of the bacterium. detailed glycomic studies enabled to better under ... | 2009 | 19538265 |
| intracellular life of coxiella burnetii in macrophages. | coxiella burnetii, the agent of q fever, is an obligate intracellular bacterium that is considered a potential biological weapon of category b. c. burnetii survives within myeloid cells by subverting receptor-mediated phagocytosis and preventing phagosome maturation. the intracellular fate of c. burnetii also depends on the functional state of myeloid cells. this review describes the mechanisms used by c. burnetii to circumvent uptake and trafficking events, and the role of cytokines on c. burne ... | 2009 | 19538264 |