Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| malignancies in women with hiv infection. | women with hiv infection have an increased risk of developing certain malignancies. these malignancies are commonly human papillomavirus (hpv)-related, reflecting the high rate of coinfection with hpv in women with underlying hiv infection. these women also have a high incidence of premalignant hpv-related changes, such as high-grade squamous intraepithelial lesions as diagnosed on pap smears and cervical intraepithelial neoplasia on cervical biopsy. screening recommendations for hiv-infected wo ... | 2008 | 19072501 |
| self-collection of genital human papillomavirus specimens in heterosexual men. | we assessed the accuracy of self-collected human papillomavirus (hpv) specimens in men compared with clinician-collected specimens from men in british columbia and determined the prevalence of hpv subtypes at different male genital sites. | 2009 | 19066196 |
| distribution and density of cd1a+ and cd83+ dendritic cells in hpv-associated laryngeal papillomas. | respiratory papillomatosis associated with human papilloma virus (hpv) infection is the most common benign laryngeal neoplasm. the age of patients at disease onset, hpv type, number of surgeries are well known prognostic factors of the disease course. the correlation between dendritic cell (dc) density in tumor tissue and clinical prognosis was established. | 2009 | 19062106 |
| whim syndrome: congenital immune deficiency disease. | warts, hypogammaglobulinemia, infections, and myelokathexis (whim) syndrome is characterized by susceptibility to human papilloma virus infection-induced warts and carcinomas; neutropenia, b-cell lymphopenia and hypogammaglobulinema-related infections; and bone marrow myelokathexis (myeloid hyperplasia with apoptosis). the purpose of this report is to review new findings about whim. | 2009 | 19057201 |
| prevalence of human papillomavirus types in cervical and oral cancers in central india. | cervical cancer that is associated with high-risk human papillomaviruses (hpv) is the most common malignancy in indian women. therefore, the establishment of a prevention program is urgently required considering both vaccination and screening. however, relatively little is known about the prevalence of the different hpv types in cervical cancers in different regions of india, particularly central india. in this study, we have determined the hpv type distribution in 180 cervical cancers of women ... | 2009 | 19056450 |
| medicines management. | 2008 | 19051531 | |
| anal intraepithelial neoplasia in a multisite study of hiv-infected and high-risk hiv-uninfected women. | to study anal intraepithelial neoplasia and its associations with anal and cervical human papillomavirus (hpv), cervical neoplasia, host immune status, and demographic and behavioral risk factors in women with and at risk for hiv infection. | 2009 | 19050387 |
| p16 ink4a immunostaining identifies occult cin lesions in hpv-positive women. | to evaluate whether p16 staining could help to recognize underestimated cervical intraepithelial neoplasia (cin) in women positive for high-risk human papillomavirus (hr-hpv) with negative biopsy. out of 1,259 women undergoing a histologic study and a simultaneous hr-hpv detection using the hybrid capture 2 test, we selected all patients testing positive for hr-hpv and having a negative biopsy (n=139), as well as all women testing negative for hr-hpv with a biopsy of either cin 1 (26 cases) or c ... | 2009 | 19047902 |
| oral rinses may help detect human papillomavirus-positive head, neck cancers. | 2008 | 19047664 | |
| activation of the enhancer of zeste homologue 2 gene by the human papillomavirus e7 oncoprotein. | the malignant phenotype of human papillomavirus (hpv)-positive cancer cells is maintained by the activity of the viral e6 and e7 genes. here, we identified the polycomb group gene enhancer of zeste homologue 2 (ezh2) as a novel downstream target for the viral oncogenes in hpv-transformed cells. ezh2 expression was activated by hpv16 e7 at the transcriptional level via e7-mediated release of e2f from pocket proteins. rna interference analyses showed that continuous ezh2 expression is required for ... | 2008 | 19047178 |
| analytical evaluation of the papillocheck test, a new commercial dna chip for detection and genotyping of human papillomavirus. | recently, a commercially available hpv dna chip, the papillocheck test, developed by greiner bio-one, has become available for human papillomavirus (hpv) genotyping. the papillocheck test is a pcr-based test using a new consensus primer set targeting the e1 hpv gene. hpv oligoprobes immobilized on a dna chip allow for the identification of 24 hpv types from the amplified product. in the present study, the analytical performance of the papillocheck test is compared to the linear array hpv genotyp ... | 2009 | 19041893 |
| augmentation of alphavirus vector-induced human papilloma virus-specific immune and anti-tumour responses by co-expression of interleukin-12. | to enhance the efficacy of a therapeutic immunisation strategy against human papillomavirus-induced cervical cancer we evaluated the adjuvant effect of interleukin-12 (il12) expressed by a semliki forest virus vector (sfv) in mice. depending on the dose and schedule, sfv-il12 stimulated antigen-specific ctl responses elicited upon immunisation with recombinant sfv expressing hpv16-e6e7 (sfvee6,7). sfvee6,7-ctl and anti-tumour activity were enhanced by a low dose of sfv-il12 to the prime immunisa ... | 2009 | 19041356 |
| acog practice bulletin no. 99: management of abnormal cervical cytology and histology. | recent evidence has shown that the risk of malignant and premalignant cervical disease and human papillomavirus (hpv) infections varies significantly with age (1,2). furthermore, evidence now shows that treatment for cervical disease carries significant risk for future pregnancies (3-7). these factors have led to a re-evaluation of the guidelines for the management of premalignant cervical disease. the purpose of this document is to define strategies for diagnosis and management of abnormal cerv ... | 2008 | 19037054 |
| analysis of human papillomavirus type 18 load and integration status from low-grade cervical lesion to invasive cervical cancer. | the clinical value of viral load and integration testing for human papillomavirus (hpv) remains unclear. data on hpv type 18 (hpv18) is limited. we examined the hpv18 viral load and integration status of 78 women with normal cervix or neoplasia. while the crude viral load appeared to increase with lesion severity, the association was not significant after normalization with sample cellularity. unlike reports for hpv16, the amino-terminal 1 region of hpv18 e2 was most frequently (71.0%) disrupted ... | 2009 | 19036939 |
| gene expression profile of cervical and skin tissues from human papillomavirus type 16 e6 transgenic mice. | although k14e6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17beta-estradiol. these findings suggest that e6 performs critical functions in normal adult cervix and skin, highlighting the need to define e6-controlled transcriptional programs in these tissues. | 2008 | 19036130 |
| different outcome of invasive cervical cancer associated with high-risk versus intermediate-risk hpv genotype. | human papillomavirus (hpv) dna sequences are associated with the large majority of invasive cervical carcinoma but the role of specific genotype(s) in the outcome of the disease is still debated. to determine the viral epidemiology in the french population of patients and the prognostic value of hpv genotypes in cervical cancer, we performed a retrospective study in 515 patients treated in our institution from 1985 to 2005. ninety-six percent of the cases were found associated with hpv dna where ... | 2009 | 19035459 |
| [laryngeal papillomatosis: etiology, diagnostics and therapy]. | papillomas are rare tumors that originate from the mucosa. they may appear in the nose, paranasal sinuses, oral cavity, larynx, trachea, or the skin. papillomas are mainly asymptomatic and are therefore mostly diagnosed coincidentally. in contrast, laryngeal papillomatosis may cause stridor, dyspnoea, and hoarseness. a viral cause of the disease seems likely, especially human papilloma virus. mechanical irritation is also a possible reason when the nose, oral cavity, or oropharynx is affected. a ... | 2008 | 19034400 |
| [construction of recombinant vaccinia virus expressing hpv18e7e6 fusion proteins and detection of its immunogenicity in mice]. | to construct one recombinant vaccinia virus expressing the hpv18 e6 and e7 fusion proteins as hpv18 therapeutic vaccine candidate, and test its immunogenicity. | 2008 | 19031699 |
| [human papilloma virus and cervical cancer]. | cervical cancer (cc) is the second most common cause of death from cancer among women worldwide and about 80% of the half of million new cases detected every year, occurs in less-developed countries. human papillomavirus is an obligate factor for the development of cc, since some hpvtype are detected in 100% of cc. hpv16 and hpv18 are the most common viral types, accounting for about 50% and 15% of cc, respectively. hpv infection is the most common sexual transmitted infection, with an estimated ... | 2006 | 19031679 |
| human papillomavirus vaccination in the united kingdom: what about boys? | in september 2008 the uk department of health initiated a human papillomavirus (hpv) immunisation programme for girls aged 12-13 for prevention of cervical cancer, which is most often caused by two hpv types. an important question, yet to be addressed, is whether boys should also be vaccinated. men also get hpv and transmit it sexually, not just women. certain hpv types are associated with genital warts, which have significant morbidity, and with difficult to treat non-cervical malignancies, inc ... | 2008 | 19027627 |
| prevention of cervical cancer. | this article reviews the burden of cervical cancer in south africa and shows that it remains the most common cancer among south african women, particularly women with least access to cervical cancer screening. it explains the rationale behind the south african cervical cancer screening policy, which is to offer all asymptomatic women three free cervical smears in a lifetime, beginning at age 30, 10 years apart. further, it illustrates that cervical cancer screening offers unique opportunities fo ... | 2008 | 19027619 |
| oropharyngeal carcinoma in non-smokers and non-drinkers: a role for hpv. | incidence of oropharyngeal squamous cell carcinoma (oscc) increased 3% annually from 1973 to 2001. oscc's can be attributed to tobacco and alcohol, but 25% are unlinked to typical risks. case-control studies on hpv detection in non-smoking/non-drinking (ns/nd) oscc patients have not previously been performed. the primary objective of this study was to determine whether high-risk hpv infection was significantly associated with development of oral squamous malignancy in non-smokers/non-drinkers. a ... | 2009 | 19027350 |
| alaska native parental attitudes on cervical cancer, hpv and the hpv vaccine. | to describe alaska native parents' knowledge of and attitudes towards cervical cancer, the human papillomavirus (hpv) and the hpv vaccine. | 2008 | 19024805 |
| viral vaccines for dermatologic disease: some additional information regarding hpv and hsv. | 2008 | 19022110 | |
| scythe/bat3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. | papillomavirus binding factor (pbf) was first identified as a transcription factor regulating the promoter activity of human papillomavirus. we previously demonstrated that pbf is an osteosarcoma-associated antigen and 92% of osteosarcoma tissues express pbf in the nucleus. moreover, pbf-positive osteosarcoma has a significantly poorer prognosis than that with negative expression of pbf. in the present study, we assessed the biological role of pbf in cell survival. overexpression of pbf induced ... | 2009 | 19018758 |
| fanconi anemia deficiency stimulates hpv-associated hyperplastic growth in organotypic epithelial raft culture. | fanconi anemia (fa) is a recessive genome instability syndrome characterized by heightened cellular sensitivity to dna damage, aplastic anemia and cancer susceptibility. leukemias and squamous cell carcinomas (sccs) are the most predominant fa-associated cancers, with the latter exhibiting markedly early disease onset and aggressiveness. although studies of hematopoietic cells derived from fa patients have provided much insight into bone marrow deficiencies and leukemogenesis, molecular transfor ... | 2009 | 19015634 |
| mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with human papilloma virus: a new tool to further the study of rpe biology. | development of immortalized mouse retinal pigmented epithelial cell (rpe) lines that retain many of their in vivo phenotypic characteristics, would aid in studies of ocular diseases including age related macular degeneration (amd). rpe cells were isolated from 18-month-old (estrogen receptor knockout) erkoalpha and erkobeta mice and their c57bl/6 wildtype littermates. rpe65 and cellular retinaldehyde binding protein (cralbp) expression, in vivo markers of rpe cells, were detected by real-time rt ... | 2009 | 19013153 |
| surgery followed by persistence of high-grade squamous intraepithelial lesions is associated with the induction of a dysfunctional hpv16-specific t-cell response. | to characterize hpv16 e6- and e7-specific t-cell immunity in patients with high-grade squamous intraepithelial lesions (hsil). | 2008 | 19010835 |
| human papillomavirus in hnscc: a european epidemiologic perspective. | the aim of this study was to assess incidence and survival of human papillomavirus-related and unrelated head and neck squamous cell carcinoma sites from 15 european population-based cancer registries. this analysis was performed on 29,265 adult (aged approximately 15 years) cancer patients diagnosed in the period from 1988 to 2002. the human papillomavirus-unrelated cancer sites had an age-standardized incidence higher than the human papillomavirus-related cancer cases (3.8 versus 2.5/100,000 y ... | 2008 | 19010264 |
| recurrent respiratory papillomatosis: update 2008. | recurrent respiratory papillomatosis (rrp) is the most common benign neoplasm of the larynx in children. over the past several years some exciting new therapeutic options as well as some relevant research into the disease process has emerged that may offer new insight and methods in managing this frustrating disease. | 2008 | 19005325 |
| high-risk human papillomavirus dna load in a population-based cervical screening cohort in relation to the detection of high-grade cervical intraepithelial neoplasia and cervical cancer. | in a population-based cervical screening cohort, we determined the value of type-specific viral load assessment for the detection of high-grade cervical intraepithelial neoplasia and cervical cancer (>or=cin2). viral load was determined by type-specific real-time pcr in women with single hpv16,-18,-31 and -33 infections, as determined by gp5+/6+-pcr. study endpoints were the detection of cumulative >or=cin2 or>or=cin3 within 18 months of follow-up. high viral loads of hpv16,-31, and -33 were pre ... | 2009 | 19003961 |
| human papillomavirus vaccine: are the concerns unfounded? | 2008 | 18997145 | |
| identification of the nuclear localization and export signals of high risk hpv16 e7 oncoprotein. | the e7 oncoprotein of high risk human papillomavirus type 16 (hpv16) binds and inactivates the retinoblastoma (rb) family of proteins. our previous studies suggested that hpv16 e7 enters the nucleus via a novel ran-dependent pathway independent of the nuclear import receptors (angeline, m., merle, e., and moroianu, j. (2003). the e7 oncoprotein of high-risk human papillomavirus type 16 enters the nucleus via a nonclassical ran-dependent pathway. virology 317(1), 13-23.). here, analysis of the lo ... | 2009 | 18996550 |
| prevalence and age distribution of human papillomavirus infection in a population of inuit women in nunavik, quebec. | our aim was to study the prevalence and age distribution of human papillomavirus (hpv) infection among inuit women in nunavik, northern quebec, a population at high risk of cervical cancer. | 2008 | 18990756 |
| infectious agents and colorectal cancer: a review of helicobacter pylori, streptococcus bovis, jc virus, and human papillomavirus. | based on the high volume of bacteria and viruses that the intestine is exposed to and the importance of infectious agents in some gastrointestinal and anogenital cancers, it is not surprising the many studies have evaluated the association between colorectal cancer and infectious agents. this review highlights investigations of four agents in relation to colorectal cancer. helicobacter pylori, streptococcus bovis, jc virus, and human papillomavirus have all been evaluated as possible etiologic a ... | 2008 | 18990738 |
| cervical cancer control research in vietnamese american communities. | census data show that the u.s. vietnamese population now exceeds 1,250,000. cervical cancer among vietnamese american women has been identified as an important health disparity. available data indicate the cervical cancer disparity may be due to low papanicolaou (pap) testing rates rather than variations in human papillomavirus infection rates and/or types. the cervical cancer incidence rates among vietnamese and non-latina white women in california during 2000 to 2002 were 14.0 and 7.3 per 100, ... | 2008 | 18990732 |
| aetiology of cancer in asia. | cancer has become the leading cause of death in many asian countries. there is an increasing trend in breast, prostate and colon cancers, which are considered as typical of economically developed countries. although breast and prostate cancer rates are still lower than in western countries, they are particularly rapidly increasing. in this paper, we review recently published literature to identify important etiologic factors affecting the cancer risk in asian populations. infectious agents such ... | 2008 | 18990005 |
| the rna stability regulator hur regulates l1 protein expression in vivo in differentiating cervical epithelial cells. | human papillomavirus (hpv) l1 and l2 capsid protein expression is restricted to the granular layer of infected, stratified epithelia and is regulated at least partly at post-transcriptional levels. for hpv16, a 79 nt late regulatory element (lre) is involved in this control. using w12 cells as a model for hpv16-infected differentiating cervical epithelial cells we show that hur, a key cellular protein that controls mrna stability, binds the lre most efficiently in nuclear and cytoplasmic extract ... | 2009 | 18986664 |
| [item no 149: epithelial and melanoma skin tumors: tumors due to human papillomavirus]. | 2008 | 18984204 | |
| descriptive epidemiology of vaginal cancer incidence and survival by race, ethnicity, and age in the united states. | vaginal cancer is a rare malignancy. it has many of the same risk factors as cervical cancer, including a strong association with persistent human papillomavirus infection. descriptive studies of the epidemiology of vaginal cancer are scarce in the literature. | 2008 | 18980291 |
| predicting the effect of successful human papillomavirus vaccination on existing cervical cancer prevention programs in the united states. | the development of a prophylactic human papillomavirus (hpv) vaccine that potentially may eliminate a majority of cervical cancers is a landmark in cancer prevention. cervical screening, however, will continue to play an important role for the foreseeable future. maintaining screening at the same intensity and simply adding on the expense of vaccination would result in redundancy of prevention efforts at enormously increased costs without necessarily further reducing cervical cancer mortality. e ... | 2008 | 18980285 |
| human papillomavirus and molecular considerations for cancer risk. | human papillomaviruses (hpvs) are a major cause of cancer globally, including cervical cancer. the hpv 'early' proteins, e6 and e7, are the chief oncoproteins involved in cancer progression. these oncoproteins are more highly expressed in high-grade dysplasias and invasive cancer coincident with reduced viral dna replication and reduced production of infective progeny virions. the e6 and e7 oncoproteins interact with several cellular proteins-classically tp53 and rb1, respectively-leading to the ... | 2008 | 18980282 |
| examining the association between socioeconomic status and potential human papillomavirus-associated cancers. | this study examined the association between county-level measures of socioeconomic status (ses) and the incidence rate of human papillomavirus(hpv)-associated cancers, including cervical, vulvar, vaginal, anal, penile, and oral cavity and oropharyngeal cancers. | 2008 | 18980274 |
| prevalence of high-risk human papillomavirus among older women. | to estimate the prevalence, genotypes, and individual-level correlates of high-risk human papillomavirus (hpv) among women aged 57-85. | 2008 | 18978096 |
| preparing for hpv vaccination in south africa: key challenges and opinions. | this article reports on qualitative research investigating key challenges and barriers towards human papillomavirus (hpv) vaccine introduction in the western cape province, south africa. a total of 50 in-depth interviews and 6 focus groups were conducted at policy, health service and community levels of enquiry. respondents expressed overall support for the hpv vaccine, underscored by difficulties associated with the current cervical screening programmes and the burgeoning hiv/aids epidemic in s ... | 2009 | 18977271 |
| prevalence, acquisition, and clearance of cervical human papillomavirus infection among women with normal cytology: hawaii human papillomavirus cohort study. | few natural history studies of cervical human papillomavirus (hpv) incidence and duration have been conducted among older women, especially from multiethnic populations. viral and nonviral determinants of hpv acquisition and clearance were examined among 972 sexually active women, ages 18 to 85 years, recruited from clinics on oahu, hawaii, and followed for a mean duration of 15 months (range, 2-56 months). interviews and cervical cell specimens for cytology and hpv dna detection by pcr, using t ... | 2008 | 18974124 |
| national ambulatory medical care survey: 2006 summary. | this report describes ambulatory care visits made to physician offices in the united states. statistics are presented on selected characteristics of the physician's practice, the patient, and the visit. | 2008 | 18972720 |
| human papillomavirus in the placenta and umbilical cord blood. | to analyze human papillomavirus (hpv) dna in umbilical cord blood and in placenta, including its cellular localization. | 2008 | 18972230 |
| kinase requirements in human cells: ii. genetic interaction screens identify kinase requirements following hpv16 e7 expression in cancer cells. | human papillomavirus (hpv) oncoproteins subvert cellular signaling pathways, including kinase pathways, during the carcinogenic process. to identify kinases targeted by the hpv16 e7 oncoprotein, shrna kinase screens were performed in rko colorectal carcinoma cell lines that differ only in their expression of hpv16 e7. our screens identified kinases that were essential for the survival of rko cells, but not essential for rko cells expressing hpv16 e7. these kinases include cdk6, erbb3, fyn, aak1, ... | 2008 | 18948598 |
| public knowledge and attitudes towards human papilloma virus (hpv) vaccination. | human papilloma virus (hpv) vaccine has undergone successful trials and has recently been approved for use for the primary prevention of cervical cancer. the aim of this study was to determine knowledge and attitudes towards hpv vaccination. | 2008 | 18947430 |
| human papillomavirus type 16 e2 protein transcriptionally activates the promoter of a key cellular splicing factor, sf2/asf. | human papillomavirus (hpv) gene expression is regulated in concert with the epithelial differentiation program. in particular, expression of the virus capsid proteins l1 and l2 is tightly restricted to differentiated epithelial cells. for hpv16, the capsid proteins are encoded by 13 structurally different mrnas that are produced by extensive alternative splicing. previously, we demonstrated that upon epithelial differentiation, hpv16 infection upregulates hnrnp a1 and sf2/asf, both key factors i ... | 2009 | 18945764 |
| control of the papillomavirus early-to-late switch by differentially expressed srp20. | the viral early-to-late switch of papillomavirus infection is tightly linked to keratinocyte differentiation and is mediated in part by alternative mrna splicing. here, we report that srp20, a cellular splicing factor, controls the early-to-late switch via interactions with a/c-rich rna elements. an a/c-rich se4 element regulates the selection of a bovine papillomavirus type 1 (bpv-1) late-specific splice site, and binding of srp20 to se4 suppresses this selection. expression of late bpv-1 l1 or ... | 2009 | 18945760 |
| recommendations for cervical cancer prevention in asia pacific. | asia oceania includes countries from both the asia pacific region and australasia, which cover very diverse geographical areas and populations as well as bearing 52% of the cervical cancer burden in the world. human papillomavirus (hpv) genotype distribution in women with normal cytology varies between countries in this region, as well as with the distribution typically observed in worldwide estimates or in western countries. hpv-16 remains the predominant oncogenic type for high-grade cervical ... | 2008 | 18945418 |
| human papillomavirus infection and cervical cancer prevention in india, bangladesh, sri lanka and nepal. | although one-third of the world cervical cancer burden is endured in india, bangladesh, nepal and sri lanka, there are important gaps in our knowledge of the distribution and determinants of the disease in addition to inadequate investments in screening, diagnosis and treatment in these countries. prevalence of human papillomavirus (hpv) infection among the general populations varies from 7-14% and the age-specific prevalence across age groups is constant with no clear peak in young women. this ... | 2008 | 18945413 |
| human papillomavirus infection and cervical cancer prevention in japan and korea. | cervical cancer is a common cancer among women in japan and korea. implementation of national cervical cancer screening programs has led to a reduction in the incidence of cervical cancer in both countries. however, over the past decade, there has been a recent marked increase in cervical cancer incidence among young women in japan. human papillomavirus (hpv) is found in the majority of cervical cancers, and hpv-16 and 18 are the two most common types. the next most frequent hpv types in cervica ... | 2008 | 18945412 |
| burden and trends of type-specific human papillomavirus infections and related diseases in the asia pacific region. | we present the burden of human papillomavirus (hpv)-related cancers (cancers of the cervix, anogenital areas, and oral cavity and pharynx) in terms of incidence and mortality, for the countries of the asia pacific region. the region contains more than half of the world population, and manifests a wide geographic diversity in the prevalence of infection with hpv, and of incidence (and mortality) rates of cancer of the cervix. in general, rates of cancer of the cervix have declined since the 1960' ... | 2008 | 18945410 |
| recommendations for cervical cancer prevention in latin america and the caribbean. | cervical cancer control in the latin america and caribbean (lac) region has been, and remains, a priority and a major public health challenge. it also provides the opportunity for the advancement of research into novel cervical cancer preventative tools including the use of prophylactic human papillomavirus (hpv) vaccines, hpv-based screening options and low technology visual inspection methods. the challenges for prevention are compounded because cervical cancer cases continue to cluster in the ... | 2008 | 18945407 |
| new approaches to cervical cancer screening in latin america and the caribbean. | cervical cancer remains an important public health problem in the latin america and caribbean region (lac), with an expected significant increase in disease burden in the next decades as a result of population ageing. prophylactic human papillomavirus (hpv) vaccine is currently unaffordable in lac countries. however, even if vaccination was implemented, an additional two decades will be required to observe its impact on hpv related disease and cancer. with some exceptions, cytology-based screeni ... | 2008 | 18945402 |
| optical detection and grading of lung neoplasia by raman microspectroscopy. | the aim of this study was to investigate whether raman spectroscopy could be used to identify and potentially grade lung neoplasia in cell samples. normal human bronchial epithelial cells (hbepcs) were analyzed by raman spectroscopy and compared with (i) hbepcs expressing human papillomavirus (hpv) type 16 e7 or cdk4; (ii) the immortalized bronchial epithelial cell line bep2d and (iii) its asbestos-transformed derivative asbtb2a. overall, raman spectroscopy, in combination with a linear discrimi ... | 2009 | 18942712 |
| hiv, human papillomavirus, and cervical neoplasia and cancer in the era of highly active antiretroviral therapy. | the objective of this study was to review the literature on the epidemiological association between human papillomavirus (hpv), hiv, and cervical neoplasia, and the impact of highly active antiretroviral therapy (haart) on this association. medline was searched using the terms 'human papillomavirus', 'hpv', 'hiv', 'cervix', 'neoplasm', and 'antiretroviral' to identify articles published before december 2006. hiv-infection was strongly associated with a higher prevalence, incidence, and persisten ... | 2008 | 18941376 |
| hpv vaccines: are they the answer? | the burden of human papillomavirus (hpv)-associated ano-genital disease is significant but the ability to generate hpv virus-like particles by the synthesis and self-assembly in vitro of the major virus coat protein l1 has transformed our prospects for preventing benign and malignant ano-genital disease caused by the common genital hpv types. | 2008 | 18940889 |
| successful surgical management of giant condyloma acuminatum (buschke-löwenstein tumor) in the genitoanal region: a case report and evaluation of current therapies. | giant condyloma acuminatum (gca; buschke-lowenstein tumor) is a human-papillomavirus-induced cauliflower-like tumor of the genitoanal region. it is characterized by its size, capability of local infiltration and high recurrence rate. we report on a 50-year-old patient presenting with a maximum finding of gca with deep infiltration into the adductor and perineal musculature, the scrotum, the penis and the para-rectum. after performing a temporary loop colostomy, the tumor was removed by wide radi ... | 2009 | 18936533 |
| human papillomavirus type spectrum in normal skin of individuals with or without a history of frequent sun exposure. | cutaneous human papillomavirus (hpv) has been widely detected in healthy skin. previous studies have found that uv radiation can activate several hpv types, and a possible role for cutaneous hpv in the development of non-melanoma skin cancer has been suggested. this study investigated the prevalence and type-spectrum of cutaneous hpv in relation to uv radiation by studying forehead skin swab samples from 50 healthy males frequently exposed to the sun and 50 healthy males who were not frequently ... | 2008 | 18931088 |
| human papillomavirus vaccination: what is the best choice? a comparison of 16 strategies by means of a decisional model. | some european countries decided to include human papillomavirus (hpv) vaccines in national immunization schedules. in order to help decision makers choose the best vaccination policy for females, a decisional model has been developed. the study was performed from the national health service perspective. several hypotheses of multi-cohort vaccination policies were compared. 'potentially avoidable infections' were chosen as the outcome. the model envisioned a short-term scenario (2008-2011). the b ... | 2009 | 18925989 |
| the human papillomavirus vaccine: the promise of cervical cancer prevention. | 2007 | 18923736 | |
| controversies in the management of anal high-grade squamous intraepithelial lesions. | anal squamous dysplasia is recognized as a spectrum of disease that ranges from low-grade intraepithelial lesions (lsil) to high-grade squamous intraepithelial lesions (hsil) to invasive anal squamous cell carcinoma (scc). recent reports have shown a significant increase in both the incidence and prevalence of both hsil and anal scc, particularly in immunocompromised patients and in men who have sex with men. these lesions are associated with chronic infection with the human papillomavirus. the ... | 2008 | 18923350 |
| cutaneous and mucosal human papillomaviruses differ in net surface charge, potential impact on tropism. | papillomaviruses can roughly be divided into two tropism groups, those infecting the skin, including the genus beta pvs, and those infecting the mucosa, predominantly genus alpha pvs. the l1 capsid protein determines the phylogenetic separation between beta types and alpha types and the l1 protein is most probably responsible for the first interaction with the cell surface. virus entry is a known determinant for tissue tropism and to study if interactions of the viral capsid with the cell surfac ... | 2008 | 18854037 |
| immunogenic properties of recombinant and synthetic peptides of human papillomavirus. | 2008 | 18853768 | |
| hpv detection rate in saliva may depend on the immune system efficiency. | human papilloma virus (hpv) has been established as a major etiological factor of anogenital cancer. in addition, hpv has also been implicated in oral carcinogenesis but its detection rates appear to be highly variable, depending on the patient population tested, the molecular methodology used, as well as the type of oral specimen investigated. for example, saliva is an oral fluid that may play a role in hpv transmission, although the detection rates of the virus are lower than tissue. recent ev ... | 2008 | 18853753 |
| human papillomavirus, cervical cancer prevention, and more. | 2008 | 18847562 | |
| immunobiology of human papillomavirus infection and vaccination - implications for second generation vaccines. | prophylactic human papillomavirus (hpv) l1 virus like particle (vlp) vaccines have been shown, in large clinical trials, to be very immunogenic, well-tolerated and highly efficacious against genital disease caused by the vaccine hpv types. however these vaccines, at the present, protect against only two of the 15 oncogenic genital hpv types, they are expensive, delivered by intramuscular injection and require a cold chain. the challenges are to develop cheap, thermo-stable vaccines that can be d ... | 2008 | 18847558 |
| analysis of adverse events of potential autoimmune aetiology in a large integrated safety database of as04 adjuvanted vaccines. | newly licensed vaccines against human papillomavirus (hpv) and hepatitis b (hbv), and several vaccines in development, including a vaccine against genital herpes simplex virus (hsv), contain a novel adjuvant system, as04, composed of 3-o-desacyl-4' monophosphoryl lipid a and aluminium salts. given the background incidence of autoimmune disorders in some of the groups targeted for immunisation with these vaccines, it is likely that autoimmune events will be reported in temporal association with v ... | 2008 | 18845199 |
| human papillomavirus vaccines: an outsider's point of view. | 2008 | 18844585 | |
| [triage value of high risk human papilloma virus detection in women with abnormal cervical cytology]. | to evaluate the triage value of high risk human papilloma virus (hrhpv) detection in the women with abnormal cervical cytology. | 2008 | 18844110 |
| risk factors for squamous cell carcinoma of the penis--population-based case-control study in denmark. | few etiologic studies of squamous cell carcinoma (scc) of the penis have been carried out in populations where childhood circumcision is rare. a total of 71 patients with invasive (n=53) or in situ (n=18) penile scc, 86 prostate cancer controls, and 103 population controls were interviewed in a population-based case-control study in denmark. for 37 penile scc patients, tissue samples were pcr examined for human papillomavirus (hpv) dna. overall, 65% of pcr-examined penile sccs were high-risk hpv ... | 2008 | 18843010 |
| [hpv infection: comparison between morphological studies and molecular biology]. | human papilloma virus plays an essential role in the development of cervical cancer. we investigated the global prevalence of human papilloma virus infection in a population of 699 women recruited at the ospedali riuniti in foggia for gynaecological controls from september 2005 to march 2007, and compared with a group of 90 women, selected on clinical aspects for human papilloma virus features. the observed prevalence was 27.4%, which is higher that that reported in the literature. in the study ... | 2008 | 18841817 |
| hpv-16 e6 l83v variant in squamous cell carcinomas of the upper aerodigestive tract. | the aim of this prospective case series study was to determine the prevalence of hpv-dna, analyze the e6 mrna expression, identify intra-type variation in the e6 oncogene in upper aerodigestive tract (uadt) squamous cell carcinoma (scc), and correlate the presence of hpv-dna with several clinical parameters and outcome. | 2009 | 18841393 |
| cell-cycle and suppressor proteins expression in uterine cervix in hiv/hpv co-infection: comparative study by tissue micro-array (tma). | the oncoproteins of human papillomavirus (hpvs) directly effect cell-cycle control. we hypothesize that regulatory and cell cycle protein expression might be additionally modified in the cervix of hiv/hpv co-infected women. | 2008 | 18840277 |
| prevalence of human papillomavirus type 16 and its variants in abnormal squamous cervical cells in northeast thailand. | to investigate the prevalence of hpv, hpv16, and hpv16 variants in scraped cervical cells cytologically diagnosed as normal cervical cell and in formalin-fixed, paraffin-embedded tissues of cervical intraepithelial neoplasia ii-iii and squamous cervical carcinoma in northeast thailand. | 2009 | 18838282 |
| clathrin- and caveolin-independent entry of human papillomavirus type 16--involvement of tetraspanin-enriched microdomains (tems). | infectious entry of human papillomaviruses into their host cells is an important step in the viral life cycle. for cell binding these viruses use proteoglycans as initial attachment sites. subsequent transfer to a secondary receptor molecule seems to be involved in virus uptake. depending on the papillomavirus subtype, it has been reported that entry occurs by clathrin- or caveolin-mediated mechanisms. regarding human papillomavirus type 16 (hpv16), the primary etiologic agent for development of ... | 2008 | 18836553 |
| proex c immunocytochemistry and high-risk human papillomavirus dna testing in papanicolaou tests with atypical squamous cell (asc-us) cytology: correlation study with histologic biopsy. | papanicolaou tests with atypical squamous cells of undetermined significance (asc-us) cytology and adjunct testing for high-risk human papillomaviruses (hr-hpv) are helpful in detecting high-grade disease. detection of disease may be further improved with molecular markers known to be overexpressed in cervical carcinoma. proex c detects 2 such molecular markers, minichromosome maintenance protein 2 and topoisomerase ii, which are associated with abnormal cell cycle regulation. | 2008 | 18834224 |
| the new hpv vaccination. | 2008 | 18834017 | |
| [it's only afterwards the medical products agency can scrutinize advertisements]. | 2008 | 18833633 | |
| single large inguinal lymph node metastasis in human papillomavirus-induced early invasive vulvar cancer of the anterior fourchette in two young women. | the incidence of human papillomavirus (hpv)-induced vulvar cancer in young women is increasing and often presents as microinvasive or early invasive tumors in a grade 3 vulvar intraepithelial neoplasia. so far, the risk of lymph node metastases in early invasive vulvar carcinoma (depth of invasion 1.1-2.0 mm) is reported to be less than 8%. we present 2 cases of young women with early invasive vulvar cancers (depth of invasion 1.5 and 2.0 mm) induced by hpv 16 and 42. in both cases, the cancers ... | 2009 | 18832852 |
| cellular distribution of tumour suppressor protein p53 and high-risk human papillomavirus (hpv)-18 e6 fusion protein in wild-type p53 cell lines. | human papillomaviruses (hpvs) are very important pathogens that can be classified as high- and low-risk types based on the lesions they cause. mucosal high-risk hpv e6 can target and degrade the tumour suppressor p53, hence it is recognized as the major cause of cervical cancer, however, due to a lack of reliable anti-e6 antibodies, the distribution of high-risk hpv e6 protein remains elusive. the present study, therefore, used a mammalian green fluorescent protein (gfp) expression system to exp ... | 2008 | 18831896 |
| infection and cervical neoplasia: facts and fiction. | whilst there is strong evidence that human papillomavirus (hpv) is the principal aetiological agent in cervical neoplasia, some other sexually transmitted agents may either contribute or protect against cervical carcinogenesis, such as the herpes virus family (hsv), cytomegalovirus (cmv), epstein-barr virus (ebv), human immunodeficiency virus (hiv) or chlamydia trachomatis (ct). epidemiological studies suggest that hsv may have a role in cervical neoplasia, but there is no clear supportive exper ... | 2009 | 18830380 |
| topical cidofovir for severe warts in a patient affected by aids and hodgkin's lymphoma. | we describe a 42-year-old man with aids and hodgkin's lymphoma whose severe and recalcitrant cutaneous warts resolved following treatment with local 1% cidofovir. clinically significant improvements were observed in a two-week period of therapy. in advanced hiv disease complicated by additional haematological malignancy, cutaneous warts may be difficult to treat and present a challenge for the attending physicians. in similar clinical condition topical anti-human papillomavirus therapy may prove ... | 2008 | 18824628 |
| [testing of a new probe 16/18/45 hybrid capture (digene) in women with high risk hpv infection]. | hpv hr detection test are needed when ascus is diagnosed on pap test. the risk of progression to cervical cancer is dependant on the hpv genotype and three types (hpv 16, 18 and 45) are found in 77.4% of the cervical cancer. here we have tested a new probe 16/18/45 (digene) that is able to detect specifically these three types. | 2009 | 18824308 |
| the epidemiology and burden of hpv disease. | margaret stanley describes what human papillomavirus is and how it causes disease. she also outlines how the new vaccine to protect against hpv works. | 2008 | 18822547 |
| men's attitudes toward receiving the human papillomavirus vaccine. | to determine men's attitudes toward receiving the human papillomavirus (hpv) vaccine. | 2008 | 18820541 |
| association of hsp90 to the htert promoter is necessary for htert expression in human oral cancer cells. | enhanced expression of human telomerase reverse transcriptase (htert) occurs frequently during cellular immortalization. the current study was undertaken to determine the mechanism regulating the htert promoter activity during cellular immortalization of human oral keratinocytes. normal human oral keratinocytes (nhoks) were immortalized with bmi-1 and the e6 oncoprotein of human papillomavirus type 16 to establish the telomerase-positive hok-bmi-1/e6 cell line. using dna-protein-binding assay, w ... | 2008 | 18820283 |
| cell-restricted immortalization by human papillomavirus correlates with telomerase activation and engagement of the htert promoter by myc. | the high-risk human papillomaviruses (hpvs) are the causative agents of nearly all cervical cancers and are etiologically linked to additional human cancers, including those of anal, oral, and laryngeal origin. the main transforming genes of the high-risk hpvs are e6 and e7. e6, in addition to its role in p53 degradation, induces htert mrna transcription in genital keratinocytes via interactions with myc protein, thereby increasing cellular telomerase activity. while the hpv type 16 e6 and e7 ge ... | 2008 | 18818322 |
| infection: is it a cause of bladder cancer? | this article reviews the literature regarding the possible correlation between infection and occurrence of bladder cancer. the pubmed literature database was searched from inception to january 2008. keywords of bladder, cancer, parasitic, bacterial, viral and infection, were used. forty studies were included in the review. several investigators support the idea that schistosomiasis is aetiologically related to the development of bladder cancer in individuals infected with schistosoma haematobium ... | 2008 | 18815920 |
| hiv-1 tat enhances replicative potential of human oral keratinocytes harboring hpv-16 genome. | introducing highly active antiretroviral therapy (haart) has significantly decreased the morbidity and mortality in human immunodeficiency virus-positive (hiv+) individuals by decreasing the viral loads and increasing the cd4+ t-cell counts. subsequently, the occurrence of many hiv-associated diseases has been dramatically declined except human papillomavirus (hpv)-associated lesions. such notion suggests that immune response is not a major determinant, and that the direct interaction between hi ... | 2008 | 18813791 |
| oral human papillomavirus lesion identified using velscope instrumentation: case report. | the role of oral human papillomavirus (hpv) in the incidence of oral carcinoma has increased among traditional non-risk patients under the age 40. this case study describes how a squamous papilloma (attributed to the hpv) was discovered using the velscope oral screening device. photographs of the lesion that might help dentists to identify these areas, using both white light and fluorescence visualization with velscope, are included. | 2008 | 18810914 |
| trade-offs in cervical cancer prevention: balancing benefits and risks. | new screening and vaccination technologies will provide women with more options for cervical cancer prevention. because the risk of cervical cancer diminishes with effective routine screening, women may wish to consider additional attributes, such as the likelihood of false-positive results and diagnostic procedures for mild abnormalities likely to resolve without intervention in their screening choices. | 2008 | 18809815 |
| potential barriers to hpv vaccine provision among medical practices in an area with high rates of cervical cancer. | potential barriers to widespread vaccination of adolescent girls against human papillomavirus (hpv) infection are poorly understood. we provide an overview of potential barriers to provision of hpv vaccine and empirical data on the concerns of medical practices that may inhibit hpv vaccine provision. | 2008 | 18809147 |
| age-specific prevalence of infection with human papillomavirus in females: a global review. | global data on age-specific prevalence of human papillomavirus (hpv) infection overall, and for high-risk hpv types 16 and 18, are essential for the future implementation of hpv prophylactic vaccines for cervical cancer prevention. | 2008 | 18809145 |
| issues in human papillomavirus vaccination in adolescents. | 2008 | 18809142 | |
| topical treatment for human papillomavirus-associated genital warts in humans with the novel tellurium immunomodulator as101: assessment of its safety and efficacy. | various methods are currently used for the treatment of anogenital warts. however, a complete cure is unlikely, and the rate of recurrence is high. | 2009 | 18808418 |