Publications

gonadotropin-releasing hormone molecular forms in mammalian hypothalamus.	multiple forms of gnrh have been detected in brain tissue of species from all nonmammalian vertebrate classes, but in mammals it is generally believed a single molecular form of gnrh is present. we have investigated the possibility that additional structural variants of gnrh are present in mammalian (sheep, rat, and human) hypothalamus. hypothalami were extracted with acetic acid and subjected to gel filtration chromatography and reverse phase hplc systems specifically designed to separate gnrh ...	1988	3131123
characterization of prolactin-releasing factor in the rat posterior pituitary.	we previously reported that the rat posterior pituitary contains a potent prl-releasing factor (prf) which is distinct from oxytocin (ot), trh, and angiotensin ii (aii). the objectives of this study were 1) to examine whether posterior pituitary extracts stimulate prl release in the presence of dopamine (da), 2) to determine the chemical nature of prf, and 3) to estimate its mol wt. perifused anterior pituitary cells were used to assess prf activity. posterior pituitaries and medial basal hypoth ...	1988	3131118
anomeric specificity of d-glucose metabolism in human erythrocytes.	the metabolism of d-[5-3h]glucose and d-[u-14c]glucose displays anomeric specificity in human erythrocytes. at close-to-physiological hexose concentrations, pure beta-d-[5-3h]glucose is metabolized at a higher rate than the corresponding pure alpha-anomer in most, but not all, subjects. this situation represents a mirror image of that found in rat erythrocytes. the anomeric preference is modulated by the extracellular concentration of d-glucose and may differ for distinct metabolic variables. th ...	1988	3131049
comparative observations of fever and associated clinical haematological and blood biochemical changes after intravenous administration of vibrio cholerae enterotoxin, staphylococcal enterotoxins and escherichia coli endotoxin in goats.		1988	3130732
human rabies--california, 1987.		1988	3130561
synergistic activation of human t cells by interleukin 1 and interleukin 6.	purified human interleukin 6 (il 6) was found to stimulate the proliferation of human tonsillar and peripheral rosetting t cells subliminally activated with phytohemagglutinin (pha). this response seemed independent of il 2 but highly dependent on the presence of accessory cells. indeed, when accessory cell-depleted tonsillar t cells were activated with pha and exposed to il 6, only minimal proliferations were observed. a similar result was obtained with il 1. however, a combination of these two ...	1988	3130269
survival of pathogenic bacteria in environmental microcosms.	the survival times of salmonella enteritidis, pseudomonas aeruginosa, staphylococcus aureus, and vibrio cholerae in natural soil and river water samples were monitored by using various differential media. s. aureus and v. cholerae failed to survive in samples of soil, groundwater, and river water with various degrees of eutrophication. the population of the introduced s. enteritidis remained fairly constant in all three samples of soils tested. in water samples, numbers of s. enteritidis and p. ...	1987	3130237
effects of calcium ionophore, a23187 and calmodulin inhibitors on intercellular communication in the rat myometrium.	we have studied the effect of a calcium ionophore, a23187, and the purported calmodulin inhibitors, calmidazolium and chlorpromazine, on direct intercellular communication between smooth muscle cells in the myometrium of delivering rats. the extent of cell-to-cell coupling was determined by exposing one portion of small strips of longitudinal myometrium to 2-[3h] deoxy-d-glucose (2-dg) and determining the distribution and apparent diffusion coefficient (da) for this tracer after a 5-h period for ...	1988	3130110
dental service in a geriatric institution.		2011	3129461
the omega-hydroxylation of arachidonic acid by human polymorphonuclear leukocytes.	incubations of [1-14c]arachidonic acid with unstimulated human polymorphonuclear leukocytes resulted in the formation of four new metabolites in a previously described reverse-phase hplc system. three of these metabolites were largely suppressed in a co/o2 (80/20, by vol.) atmosphere indicating a cytochrome-p450-dependent monooxygenase reaction. in agreement with this assumption is their nadph/o2-dependent formation in the microsomal fraction. one metabolite was identified by gas chromatography/ ...	1988	3129296
clinical findings in 12 patients with mps iv a (morquio's disease). further evidence for heterogeneity. part ii: dental findings.	typical dental changes were present in all cases, although they were of variable degree. however, the tooth morphology would appear to be highly specific for mps iv a, and is not found in mps iv b (beta-galactosidase deficiency) or the recently delineated mps iv c (enzyme defect unknown). thus the dental changes have a very useful diagnostic potential in mild atypical cases of mps iv a, although they may only be demonstrable radiologically in some such cases.	2011	3129222
low trh-tsh responses in human essential hypertension.	thirty female and male essential hypertensive patients and eighteen normotensive controls were submitted to the trh-tsh conventional test (200 ug intravenously, bolus injection of trh). supramaximal doses of 400 and 600 ug were repeated with a week interval to each subject. hypertensives showed a significant lower response to both conventional and supramaximal trh doses. hypothalamic-pituitary-thyroid axis abnormalities, secondary to trh-receptor alterations, could account for this result.	1988	3129219
antinuclear antibody-negative systemic lupus erythematosus (sle) and severe renal involvement: close correlation between disease activity and appearance of circulating anticoagulant.	a 16-year-old girl meeting the criteria for sle is described. salient features of the clinical course included active glomerulonephritis with dense subepithelial deposits on electron microscopy, pulmonary embolism, axillary vein thrombosis, arthritis, serositis and fever. disease activity correlated with the presence of lupus anticoagulant as measured by vdrl and partial thromboplastin time (ptt). her serum was consistently negative to ana, anti-ds-dna, anti-ss-dna, ena, anti-ro, anti-la, and le ...	2007	3128493
human antibody responses against schistosomal antigens. i. antibodies from patients with ancylostoma, ascaris lumbricoides or schistosoma mansoni infections react with schistosome antigens.	sera of patients with either hookworm infections or ascariasis, who are from areas nonendemic for schistosoma mansoni, contain antibody reactivity against extracts of s. mansoni schistosomula. such patients with hookworm, but not those with ascaris lumbricoides, also express considerable antibody activity against intact schistosomula and schistosomular membrane preparations. sera from patients with schistosomiasis mansoni also contain these activities. because these three helminthic infections o ...	1988	3128128
association between o blood group and occurrence and severity of diarrhoea due to escherichia coli.	during studies of diarrhoea due to escherichia coli in 316 adult volunteers, abo and rh blood group determinations were done to look for differences in the occurrence or severity of illness in association with certain blood groups. in studies using heat-labile enterotoxin-producing e. coli, volunteers with o blood group had a significantly higher attack rate for diarrhoea than persons with other blood groups. in contrast, in studies with enteropathogenic or heat-stable enterotoxin-producing e. c ...	1987	3127953
the ideological construction of risk: an analysis of corporate health promotion programs in the 1980s.	the nature of theoretical knowledge about health promotion and disease prevention programs at the worksite is examined in the context of knowledge as ideological construction. the emergence of the discourse about health promotion is linked to corporate attempts to reduce their share of medical expenditures and solve problems of productivity and absenteeism which plague the american workforce. although not always evident, corporate managers choose selectively from a body of knowledge about medica ...	2011	3127894
disease and non-battle injuries among u.s. marines in vietnam.		2011	3127752
[enterostoma therapy--a pilot course in the essen education center of the german nursing association].		2011	3127632
an interleukin 2 binding factor in human serum.		1988	3127085
herpes zoster, postherpetic neuralgia, and interferon-gamma.		2011	3126691
renal aspergilloma--a case illustrating the problems of medical therapy.	the second documented case of renal aspergilloma due to aspergillus flavus is presented. the merits of the medical therapy that failed are discussed. pathological examination showed a nidus of aspergillus around suture material persisting from a pyelolithotomy operation 2 years before in india. we argue that this was the reason for the failure of the medical therapy. this is the first case of its kind reported.	1987	3126459
early treatment of adult respiratory distress syndrome with positive end-expiratory pressure.		2011	3126425
[magnetic resonance imaging in dissection of the aorta].	in order to evaluate the usefulness of this new exploratory method in dissection of the aorta, 13 patients (10 men and 3 women, mean age 58 +/- 14 years) were examined by means of an 0.5 tesla magniscan 5000 nuclear magnetic resonance machine. fifteen examinations were performed: 5 in patients with actual aortic dissection (type a 4 including one acute, type b1), 5 in patients previously operated upon for type a dissection and 5 for suspected acute aortic dissection unconfirmed by other examinat ...	2011	3125805
man's place in hominoidea as inferred from molecular clocks of dna.	divergence dates among primates were estimated by molecular clock analysis of dna sequence data. a molecular clock of eta-globin pseudogene was calibrated by setting the date of divergence between catarrhini and platyrrhini at 38 million years (myr) ago. the clock gave dates of 25.3 +/- 2.4, 11.9 +/- 1.7, 5.9 +/- 1.2, and 4.9 +/- 1.2 myr ago ( +/- refers to standard error) for the separation of rhesus monkey, orangutan, gorilla, and chimpanzee, respectively, from the line leading to humans. in p ...	1987	3125331
regulation of ige synthesis in atopic disease.		2011	3125207
hip pain in an anticoagulated patient.		2011	3125206
epidermal growth factor, but not thyrotropin, stimulates the expression of c-fos and c-myc messenger ribonucleic acid in porcine thyroid follicle cells in primary culture.	previous studies have shown that tsh stimulates functional parameters in cultures of porcine follicle cells, but has no stimulatory effect on their growth. epidermal growth factor (egf), on the other hand, is a potent mitogen in such cells. the aim of the present investigation was to study the effect of egf and tsh on the expression of proto-oncogene mrna in porcine thyroid follicle cells. the addition of egf caused a marked increase in the c-fos and c-myc mrna levels. stimulation of cells with ...	1988	3125035
inhibition of adenylate cyclase from luteinized rat ovary by monovalent cations: roles of the stimulatory guanine nucleotide-binding regulatory component and stimulatory hormone receptor.	sodium and other monovalent cations (added as chloride salts) inhibited adenylate cyclase of luteinized rat ovary. sodium chloride (150 mm) inhibited basal enzyme activity by 20%. sodium chloride inhibition was enhanced to 34-54% under conditions of enzyme stimulation by guanine nucleotides (gtp and its nonhydrolyzable analog 5'-guanylyl imidodiphosphate), fluoride anion, and agonists (ovine luteinizing hormone (olh) and the beta-adrenergic catecholamine isoproterenol) acting at stimulatory rece ...	1988	3124764
study protocol: a randomized clinical trial of total parenteral nutrition in malnourished surgical patients.	csp #221 is a randomized multiinstitutional clinical trial to assess the efficacy of 10 d of perioperative total parenteral nutrition (tpn) in reducing morbidity and mortality in malnourished patients undergoing intraperitoneal and/or intrathoracic operations. in this paper a detailed protocol for the clinical efficacy trial is presented primarily as a reference document for use in interpretation of the results of the clinical trial. it is also anticipated, however, that review of this protocol ...	2011	3124598
[potential use of serological methods in detecting cholera toxin].	in the study of 50 vibrio cholerae museum strains, 45 of them producing cholerigenic effect in suckling rabbits, cholera toxin, determined by means of the passive immune hemolysis (pih) test, has been detected in the supernatant of the culture fluid of only two strains: v. cholerae 569 b, a well-known producer of cholera toxin, and v. cholerae (eltor) 1310, from whose population a toxigenic variant has been obtained by selection. to study the capacity of v. cholerae for producing toxin in vitro, ...	1987	3124418
isolation of salmonella using three selective enrichment broths from sausages naturally contaminated. its relationship with other microorganisms that produce food toxi-infections.	recently a great number of cases of human salmonellosis has been observed, and contaminated foods are the most important source of gastro-intestinal diseases by salmonella. a comparative study of the efficiency of salmonella spp. isolation from different kinds of sausage was carried out, using selenite-cystine (sc), müller-kauffmann tetrathionate (mk) and rappaport-vassiliadis (rv/43) broths. in addition, other microorganisms that produced food toxi-infections were investigated. the percentage o ...	1987	3124372
characterization of the pseudomonas aeruginosa reca gene: the les- phenotype.	the les- phenotype (lysogeny establishment deficient) is a pleiotropic effect of the lesb908 mutation of pseudomonas aeruginosa pao. lesb908-containing strains are also (i) deficient in general recombination, (ii) sensitive to uv irradiation, and (iii) deficient in uv-stimulated induction of prophages. the p. aeruginosa reca-containing plasmid pkml3001 complemented each of these pleiotropic characteristics of the lesb908 mutation, supporting the hypothesis that lesb908 is an allele of the p. aer ...	1988	3123459
extracorporeal gas exchange in acute respiratory failure.		2011	3122975
plasmids in bacteria exposed to activated neutrophils mediate mutagenesis when transferred to new hosts.	the plasmid puc18 contains a lacz alpha-complementation gene that codes for a small peptide that can complement the delta m15 mutation of the escherichia coli lacz (beta-galactosidase) gene, converting bacteria carrying that mutated gene from the lacz- to the lacz+ phenotype. this plasmid was used in experiments designed to study mutagenesis by human neutrophils. e coli carrying puc18 were incubated with neutrophils under conditions in which little ingestion of the bacteria took place; the plasm ...	1988	3122860
rescue of menotrophin cycles prone to develop ovarian hyperstimulation.	in an attempt to prevent the loss of 'overstimulated cycles' associated with human menopausal gonadotrophin (hmg)-induced ovulation, oestradiol levels and ovarian follicular state were monitored in 12 women with 'overstimulated cycles' after withholding hmg for several days. human chorionic gonadotrophin (hcg) was administered when oestradiol levels were less than or equal to 1700 pg/ml and the leading follicles between 17 and 22 mm in diameter. during the withholding period follicular growth co ...	1987	3122819
differential effects of 15-hpete on arachidonic acid metabolism in collagen-stimulated human platelets.	the 15-hydroperoxyeicosatetraenoic acid (15-hpete) has been shown to affect platelet aggregation induced by collagen, arachidonic acid (aa), and pgh2-analogue. furthermore, it also inhibits the platelet cyclooxygenase and lipoxygenase enzymes, and prostacyclin synthase. the present study was designed to test the effect of 15-hpete on the mobilization of endogenous aa in collagen-stimulated human platelets. for this purpose, human platelets pretreated with bw755c (a dual inhibitor of cyclooxygena ...	1988	3122753
[24-hour efficacy of a system of transcutaneous administration of nitroglycerin. evaluation by the exercise test and gamma angiography].	the effects of a nitroglycerin transdermal therapeutic system (tts ng 10 mg/24 h) 24 hours after application were evaluated by exercise left ventricular radionuclide cineangiography. 20 patients with ischemic heart disease were included in a double-blind, within patient, acute study comparing tts ng to placebo. were measured: exercise-test parameters and global (ef) and regional (ref) ejection fractions at rest and during exercise. at maximum load, the double product rose from 18,680 +/- 4,118 w ...	2011	3122628
[fibrous lesions of the skeleton in infants and children].		2011	3122625
effects of methylprednisolone on acute lung paraquat toxicity in sheep.	infused into sheep, paraquat causes increased flow of protein-rich lung lymph, increased prostanoid production, and neutrophil accumulation in the lung. the effects of high-dose methylprednisolone on the response to paraquat infusion were studied in awake sheep with chronic lung lymph fistulas. seven sheep were infused with paraquat (30 mg/kg) alone. six sheep received methylprednisolone (1.0 g plus 0.5 g/h intravenously), beginning 30 min before paraquat (pretreatment), and 5 received methylpre ...	1988	3122611
encainide-induced hyperglycemia.	twenty-three patients were treated for at least one month with encainide, a new antiarrhythmic drug. no patient was treated for hyperglycemia prior to encainide therapy. during encainide administration, five episodes of marked hyperglycemia (serum glucose level greater than or equal to 200 mg/dl) developed in four patients. (one patient received encainide twice.) the mean pretreatment glucose level was 190 +/- 69 mg/dl and rose to 397 +/- 163 mg/dl after one month of encainide therapy in patient ...	2011	3122563
mucosal and serum immunity following commensal enteric colonization.		1987	3122537
purification of an octamer sequence (atgcaaat)-binding protein from human b cells.	the highly conserved octamer sequence atgcaaat or its inverse complement found in all human and murine immunoglobulin gene promoters has been demonstrated to be necessary in the lymphoid-specific transcription by deletion analysis. trans-acting factors that interact with the octamer motif are thought to be involved in this tissue-specific expression. using a gel mobility shift assay, we have identified both lymphoid-specific and ubiquitous nuclear factors that interact with a human gamma 1 heavy ...	1987	3122182
trials of furazol and some other drugs in intestinal amoebiasis.		2011	3121763
antibody to trypanosoma cruzi neuraminidase enhances infection in vitro and identifies a subpopulation of trypomastigotes.	a rabbit antibody to the neuraminidase of the infective form of trypanosoma cruzi identifies a subpopulation of trypomastigotes that expresses neuraminidase. complement-mediated lysis by the antibody selectively destroys 30 to 40% of the trypomastigotes, supporting the conclusion that the immune antibody binds to a subset of parasites. the trypomastigotes that react with the immune antibody are the only ones expressing neuraminidase because the trypomastigotes that survive complement-mediated ly ...	1988	3121750
forecasting client transitions in british columbia's long-term care program.	this article presents a model for the annual transitions of clients through various home and facility placements in a long-term care program. the model, an application of markov chain analysis, is developed, tested, and applied to over 9,000 clients (n = 9,483) in british columbia's long term care program (ltc) over the period 1978-1983. results show that the model gives accurate forecasts of the progress of groups of clients from state to state in the long-term care system from time of admissio ...	2010	3121537
combined effects of the mycotoxins aflatoxin b1 and cyclopiazonic acid on sprague-dawley rats.	this study was conducted to determine whether exposure to cyclopiazonic acid (cpa) and aflatoxin b1 (afb1) would alter the toxicity associated with exposure to either toxin individually. groups of male rats were administered 0, 0.1 or 4.0 mg cpa/kg body weight/day intragastrically (three groups per dose level) for three consecutive days and 30 min after each of these cpa doses the rats were dosed by gavage with 0, 0.1 or 2.0 mg afb1/kg body weight/day. six of the 12 rats given each of these nine ...	1987	3121482
sequential antibiotic therapy in acute leukemia.		2011	3121466
how best to use nitrates.		2011	3120926
eczema after intravenous infusion of immunoglobulin.		2011	3120918
refractive surgery.		2011	3120886
novel transcripts from the ultrabithorax domain of the bithorax complex.	we present a detailed analysis of the transcriptional products of the bithoraxoid (bxd) region of the ultrabithorax domain in the bithorax complex of drosophila melanogaster. this region is transcribed twice during development: between 3 and 6 hr of embryogenesis, a set of early transcripts, 1.1 to 1.3 kb in size, is synthesized; from the midthird larval instar through the adult stages, a late 0.8-kb transcript is synthesized. we have sequenced five cloned cdnas representing early transcripts an ...	2010	3119423
specific reduction of n,n-dimethylnitrosamine mutagenicity in drosophila melanogaster by dimethyl sulfoxide.	dimethyl sulfoxide (dmso) used as a solvent has been observed to complicate mutagenicity screens by interacting with tested chemicals to yield false positives or negatives. we have used dmso as a solvent in the drosophila melanogaster recessive sex-linked lethal mutation assay and find that it reduces, but does not abolish, the detectable mutagenicity of n,n-dimethylnitrosamine (dmn). its use as a solvent with procarbazine, another promutagen, shows no effect on mutagenicity in drosophila. dmso ...	2011	3119334
[the structure of products of modification of nucleotides and dna by ethyleneimine and thio-tepa].	previously undescribed products of dgmp, gmp, amp, dcmp and tmp aminoethylation by ethylenimine and n,n',n"-triethylenethiophosphoamide (thio-tepa) have been obtained and shown to be aminoethyl esters of nucleotides with the free or substituted amino group. in case of dgmp and gmp ethylenimine and tio-tepa alkylate not only phosphate but also the base residue at the n7 position. the 7-aminoethyl derivatives of dgmp and gmp, which thio-tepa afforded, were characterized whereas the corresponding e ...	2011	3118884
antimicrobial activity of lysozyme against bacteria involved in food spoilage and food-borne disease.	egg white lysozyme was demonstrated to have antibacterial activity against organisms of concern in food safety, including listeria monocytogenes and certain strains of clostridium botulinum. we also found that the food spoilage thermophile clostridium thermosaccharolyticum was highly susceptible to lysozyme and confirmed that the spoilage organisms bacillus stearothermophilus and clostridium tyrobutyricum were also extremely sensitive. several gram-positive and gram-negative pathogens isolated f ...	1987	3118808
acute phase reaction following chemotherapy.		2011	3118119
intravenous therapy: expanding the bounds of safety.		2011	3118063
pseudoatrophy of the brain with valproic acid monotherapy.	a patient is described who, while on valproic acid monotherapy, developed reversible shrinkage of the brain, documented by computerized tomography with associated cognitive deficit. although pseudoatrophy has been reported with steroid therapy, this is the first implication of an anticonvulsant drug in the etiology of that condition.	2011	3117347
effect of anaemia on fetal acid-base status.	in 79 pregnancies with erythroblastosis fetalis, fetal blood was sampled to assess the level of anaemia. significant correlations were found between the haemoglobin concentration and umbilical artery ph, bicarbonate concentration and base excess. compensatory mechanisms help to maintain oxygen supply in anaemia but their failure is associated with hydrops fetalis.	2011	3117096
intestinal epithelial function and villus surface area in rats with bile fistulae.	we have previously found reduced absorption of vitamin b12 in rats with choledochocolic fistulae. to investigate whether the reduction is caused by epithelial dysfunction or mucosal hypoplasia, choledochocolic fistulae were made in 11 rats, whereas 10 rats were sham-operated. the epithelial function was evaluated 9 days later by measuring the uptake of 57cob12 and glucose in perfused intestinal segments and by determining the activities of 11 mucosal enzymes. hypoplasia was investigated by perfo ...	1987	3116662
[comparative in vitro activity of 10 new 4-quinolones against enteropathogenic bacteria].	the susceptibility has been determined of 169 shigella spp., 93 salmonella spp., 68 yersinia enterocolitica, 34 vibrio cholerae 0:1, and 34 campylobacter jejuni, isolated in central africa and in belgium, to ten fluoroquinolones: ciprofloxacin, ofloxacin, norfloxacin, pefloxacin, enoxacin, amifloxacin, ci-934, a-56619, a-56620 and ro 23-6240. all quinolones were active against the strains tested, showing an mic90 between 0.004 mg/l and 2 mg/l for strains susceptible to nalidixic acid and an mic9 ...	1987	3116489
[central mechanisms of the development of ischemic disorders of heart rhythm].	the activity of afferent and internuncial neurons of the bulbar cardiovascular centre (bcvc) was evaluated, using microelectrodes, in conditions of serotonin microinjections, altered blood gas composition and sensomotor cortical stimulation, in acute experiments in cats and rabbits. the afferent flow from ischemized myocardium was examined at the level of nodular-ganglion neurons. cortical stimulation, changed blood o2 and co2 proportions and the afferent message related to impaired coronary flo ...	1987	3116317
primary nursing. a modified approach to cost-effective quality care.		2011	3115890
hypophosphataemia: a feature of malaria?		1987	3115481
chorionic villi sampling: cytogenetic and clinical findings in 500 pregnancies.	the cytogenetic findings were analysed in a series of 500 pregnancies in which chorionic villi sampling was performed. in all cases a direct method was used, karyotyping being successful in 481 cases (96.2%). the main indication for sampling was maternal age over 36 (412 cases; 82.4%). abnormal laboratory findings resulted in 24 terminations of pregnancy (4.8%); in addition five unexpected balanced chromosome rearrangements were detected. twelve of 15 cytogenetic discrepancies were detected at a ...	2011	3115477
delay of development of transmural irreversible ischaemic injury in canine myocardium.	during the course of experimentally induced myocardial ischaemia affected tissue initially suffers reversible ischaemic injury or, if ischaemia persists, injury of increasing severity before becoming irreversibly damaged. this state is characterized by tissue necrosis and referred to as myocardial infarction. the purpose of this study was to investigate whether it is possible to delay or perhaps even prevent the development of irreversible ischaemic injury. ischaemia was induced by coronary arte ...	1987	3114945
characterization and cloning of alloreactive t lymphocytes from pancreas allografts transplanted into diabetics.		2011	3114928
implication of ornithine decarboxylase and polyamines in pancreatic growth of neonatal rats.	the current study examines the effects of alpha-difluoromethylornithine (dfmo), an irreversible ornithine decarboxylase inhibitor, on pancreatic growth and development of rat neonates. newborn rats were given daily subcutaneous injections of 300 or 500 mg kg-1 dfmo and killed after 7, 14, 21, and 28 days of treatment. pancreatic weights and dna, rna, protein, amylase and chymotrypsin total contents (per pancreas) and concentrations were evaluated at the end of each period. inhibition of body wei ...	1987	3114741
schistosoma mansoni: autoradiographic tracking studies of isotopically-labelled challenge parasites in naive and vaccinated cba/ca mice.	the migration of isotopically-labelled challenge parasites of schistosoma mansoni in naive cba/ca mice, and cba/ca mice vaccinated 4 weeks previously with about 600 radiation-attenuated cercariae, has been followed by means of compressed organ autoradiography. in naive mice, only 16% of the challenge parasites failed to migrate from the skin to the lungs, whereas up to half of the individuals that succeeded in reaching the pulmonary vasculature did not move on to the liver. the tracking techniqu ...	1987	3114702
structural and immunochemical characterization of the o-haptens of brucella abortus lipopolysaccharides from strains 19 and 2308.	the o-haptens of the major fraction (f5a) of b. abortus (strains 2308 and 19) membrane bound smooth lipopolysaccharide (slps) were prepared by hydrolysis of f5a native slps in 1% acetic acid at 100 degrees c for 2 h. after hydrolysis, o-haptens were separated from lipid a-protein complex by centrifugation, and from small fragments by ultrafiltration of molecular weight cut-off (mwco) 1.0 x 10(3). these carbohydrate haptens were identified by precipitin-inhibition assay and further fractionated b ...	1987	3114617
medical stereotypes and medical realities.		2011	3113577
oesophageal pain exacerbated by propranolol.		2011	3113570
proteinuria: value as predictor of cardiovascular mortality in insulin dependent diabetes mellitus.	the relation between diabetic microangiopathy and macroangiopathy was studied by analysing the relative mortality from cardiovascular disease in patients with insulin dependent diabetes mellitus with and without persistent proteinuria. the study group comprised 2890 diabetics diagnosed between 1933 and 1972 before the age of 31, and the study was conducted by using the linear logistic discrete failure time model. in patients with proteinuria the relative mortality from cardiovascular disease was ...	2011	3113569
studies on transmission of human non-a, non-b hepatitis to marmosets.	two sera obtained from four healthy blood donors, which caused non-a, non-b post-transfusion hepatitis in two recipients, were experimentally inoculated into nine marmosets. three of seven marmosets developed acute hepatitis characterized by the elevation of serum concentrations of glutamic pyruvic transaminase (gpt) and/or isocitric dehydrogenase (icd) 8-11 weeks after inoculation. four of seven showed histopathological changes of acute hepatitis in liver biopsy specimens during the biochemical ...	1987	3112304
[in vitro antibacterial activity of new derivatives of pyridonecarboxylic acid, norfloxacin, ofloxacin, enoxacin and ciprofloxacin, against vibrio cholerae o-1].		1987	3112282
[drug-resistance and transferable r plasmids in vibrio cholerae o-1 and non o-1, v. fluvialis and v. parahaemolyticus recently isolated from human sources].		1987	3112272
distinct culture requirements for activation and proliferation of human peripheral blood b lymphocytes by staphylococcus aureus cowan strain and growth factors.	the concentration of fetal calf serum (fcs) and the culture period were the crucial culture conditions in measuring b cell growth factor (bcgf) and il-2 activity in vitro. higher concentrations of fcs (10-15%) significantly inhibited bcgf activity; whereas, lower concentrations of fcs (less than 2.5%) were not sufficient for the response to il-2. kinetic experiments showed that the culture period for bcgf should be shorter than that for il-2, while bcgf in combination with il-2 induced a synergi ...	1987	3112237
anemia-inducing substance (ais) in advanced cancer: inhibitory effect of ais on the function of erythrocytes and immunocompetent cells.	the effects of anemia-inducing substance (ais), found in the plasma of tumor-bearing subjects, on red blood cells (rbc) and cellular immunity were examined. the results obtained may be summarized as follows: 1) the osmotic resistance and the deformability of rbc were decreased in patients with terminal cancer. 2) normal human rbc were made less deformable and their membrane was made fragile by treatment with cachectic plasma from those patients, and these changes in physical properties were irre ...	1987	3112075
my personal impressions at the national cancer center research institute during my 4 months' stay as a fellow of the foundation for promotion of cancer research, 1986.		2011	3112066
expression of genes in cloned murine cell lines that can be maintained in both interleukin 2- and interleukin 3-dependent growth states.	two cloned murine cell lines, fd.c/1 and 32dcl-23 exhibit switching of lymphokine-dependent growth states. the bone marrow-derived fd.c/1 and 32dcl-23 cell lines are normally grown in culture medium supplemented with interleukin 3 (il3). the replacement of il3 with interleukin 2 (il2) in the medium results in an increase in il2 receptor expression in fd.c/1 and 32dcl-23 cells and the switching of cells to an il2-dependent growth state. we have compared patterns of protein and phosphoprotein synt ...	2011	3111985
lower oesophageal contractility as an indicator of brain death in paralysed and mechanically ventilated patients with head injury.		2011	3111608
analogs of 9-deazaadenosine: potent inhibitors of methylthioadenosine phosphorylase.		1987	3111473
[orodental pathology in algerian preschool children].		2011	3111430
oculocerebrorenal syndrome: case report with ct and mr correlates.		2011	3111218
measurement of changes in cellular calcium metabolism in response to thyrotropin-releasing hormone.		2011	3110553
t suppressor cell growth factor and anti-cd3 antibodies stimulate reciprocal subsets of t lymphocytes.	because of the central role of il-2 in clonal expansion of t cells, we have postulated that lymphocyte subpopulations with opposing regulatory functions might be independently regulated by differential requirements for expression of cell-surface il-2-r. purified cd4+ and cd8+ cells proliferated in an il-2-dependent manner to crosslinked anti-t cell receptor antibodies (anti-cd3-seph). similarly, both cd4+ and cd8+ cells became il-2 responsive after incubation in t suppressor cell growth factor ( ...	2011	3110353
caloric requirements in total parenteral nutrition.	resting energy expenditure (ree) was measured in 100 consecutive total parenteral nutrition (tpn) patients. only forty-eight percent of the measured rees were within 90-110% of the predicted harris-benedict values. a literature review revealed 191 published guidelines for non-protein caloric requirements of hospitalized tpn patients. these guidelines were appropriately matched and applied to the 100 individual tpn patients. the relationship between the recommended caloric supply and measured cal ...	2011	3110244
experimental vibrio el-tor infected water fish breeding. stressing reservoir establishment in loach and finless eels.		1987	3109842
clinical algorithms: irregular vaginal bleeding.		2010	3109594
differences between saccharomyces cerevisiae and bacillus subtilis in secretion of human lysozyme.	saccharomyces cerevisiae secreted human lysozyme in the medium as an active form when the signal peptides of chicken lysozyme and a chicken lysozyme-aspergillus awamori glucoamylase hybrid were used, whereas it did not synthesize any human lysozyme protein by using the signal peptide of a. awamori glucoamylase. the secreted lysozyme was easily purified and crystallized. on the other hand, bacillus subtilis secreted an inactive human lysozyme, which seemed to have incorrect disulfide bonds, with ...	1987	3109419
differences between saccharomyces cerevisiae and bacillus subtilis in secretion of human lysozyme.	saccharomyces cerevisiae secreted human lysozyme in the medium as an active form when the signal peptides of chicken lysozyme and a chicken lysozyme-aspergillus awamori glucoamylase hybrid were used, whereas it did not synthesize any human lysozyme protein by using the signal peptide of a. awamori glucoamylase. the secreted lysozyme was easily purified and crystallized. on the other hand, bacillus subtilis secreted an inactive human lysozyme, which seemed to have incorrect disulfide bonds, with ...	1987	3109419
histamine binding proteins identified in healthy subjects and asthmatic patients.	histamine-binding proteins have been isolated from healthy subjects and patients with endogenous bronchial asthma. histaminopectic properties were exhibited mainly by iga, igg, igm immunoglobulins, orosomucoid, albumin and ceruloplasmin. quantitative determination of the identified proteins showed that in the control group immunoglobulins bound histamine in 97.5%, whereas in asthmatics the corresponding percentage (about 81%) was statistically significantly lower.	2011	3109351
immunological relationship among glycogen-protein complexes of different species.	glycogen-protein complexes from the muscles of celerio euphorbiae and horse as well as from the livers of frog, carp and man were isolated and used as antigens. after immunization of rabbits antisera were obtained from which fractions of immunoglobulins were isolated. antibodies were used in agar immunodiffusion tests and in quantitative reaction of immunoprecipitation with glycogens. the immunoprecipitation test proved the occurrence of quantitative differences in cross reaction of complexes wi ...	1986	3109350
altered metabolic properties of cultured skin fibroblasts in alzheimer's disease.	alzheimer's disease is associated with selective neuronal loss, the cause of which is undetermined. evidence indicating a predisposing genetic factor associated with this disease suggests that important alterations may be expressed in tissues other than the brain. because abnormal glucose and energy-related metabolism have been identified in both in vivo and in vitro studies of brain, we conducted a study to examine related measures in cultured skin fibroblasts from six patients with alzheimer's ...	2010	3109316
drug-resistant tuberculosis in a southern california hospital. trends from 1969 to 1984.	resistance to one or more antituberculosis drugs was found in 98 of 281 (35%) patients hospitalized at harbor-ucla with culture-positive tuberculosis between 1980 and 1984. resistance to antituberculosis drugs occurred in 23% of patients who had not been previously treated, whereas previously treated patients had a 59% rate of resistance. the overall rates of drug resistance had not significantly changed from prior studies at this hospital. drug resistance was also found in patients with extrapu ...	1987	3109291
reflex regulation of atrioventricular conduction.	we evaluated the time course of baroreflex modulation of atrioventricular (av) nodal conduction in anesthetized dogs (n = 28). beat-by-beat changes in heart rate (hr) and av interval (avi) evoked by transient alterations in arterial pressure (ap) were recorded in the intact state, after vagotomy, and following stellectomy. under each experimental condition, alterations in ap induced parallel changes in hr and avi with maximum hr and avi responses occurring simultaneously. in three animals, ap al ...	1987	3109256
cigarette smoking among blacks and other minority populations.		2010	3108653
[influence of bcg in the control of humoral deficiency induced by mastocytoma p-815].	viable bcg bacilli, in a lipid emulsion, inoculated intravenously, were capable of reverting the profound humoral immunosuppression induced in adult dba/2 mice by the mastocytoma p-815. bcg increased not only the number of hemolytic plaque forming cells, but also the serum titers of hemagglutinating igm antibodies. however, no blocking effect was detected on normal tumor progression.	1986	3108617
comparison of the chinese schema and the international antigenic typing system for serotyping pseudomonas aeruginosa.	twelve strains of pseudomonas aeruginosa representing 12 serogroups in the serogrouping schema used in the people's republic of china were compared with serogroups in the international antigenic typing system (iats). the first eight groups originated in the people's republic of china, and group ii appears to have a new major antigen that is not found in the iats. groups i, iii, iv, v, vi, vii, and viii correspond to groups 11, 6, 9, 4, 8, 3, and 1, respectively, of the iats. groups ix, x, xi, an ...	1987	3108310
biosynthesis and processing of platelet gpiib-iiia in human megakaryocytes.	platelet membrane glycoprotein iib-iiia forms a calcium-dependent heterodimer and constitutes the fibrinogen receptor on stimulated platelets. gpiib is a two-chain protein containing disulfide-linked alpha and beta subunits. gpiiia is a single chain protein. these proteins are synthesized in the bone marrow by megakaryocytes, but the study of their synthesis has been hampered by the difficulty in obtaining enriched population of megakaryocytes in large numbers. to examine the biosynthesis and pr ...	1987	3108266
endothelial cell proliferation may be mediated via the production of endogenous lipoxygenase metabolites.	endogenous regulators of endothelial cell proliferation have not been clearly defined. we investigated whether the cyclooxygenase and/or lipoxygenase metabolites are involved in this process, and report that lipoxygenase products can modulate endothelial cell growth. nordihydroguaiaretic acid--a lipoxygenase inhibitor, inhibited endothelial cell proliferation as well as dna synthesis. 5,8,11,14-eicosatetraynoic acid--an inhibitor of both lipoxygenase and cyclooxygenase also inhibited endothelial ...	1987	3107553