Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| evaluation of non-inferiority of intradermal versus adjuvanted seasonal influenza vaccine using two serological techniques: a randomised comparative study. | although seasonal influenza vaccine is effective in the elderly, immune responses to vaccination are lower in the elderly than in younger adults. strategies to optimise responses to vaccination in the elderly include using an adjuvanted vaccine or using an intradermal vaccination route. the immunogenicity of an intradermal seasonal influenza vaccine was compared with that of an adjuvanted vaccine in the elderly. | 2010 | 20504306 |
| synthesis and antiviral studies of novel n-sulphonamidomethyl piperazinyl fluoroquinolones. | a series of novel n-sulphonamidomethyl piperzinyl fluoroquinolones were synthesized and screened antiviral activity. eight compounds were synthesized through modifying the n(4)-hydrogen of piperazine in fluoroquinolones with formaldehyde and sulphanomides by mannich reactions. the structures of the synthesized compounds were characterized by means of their ir and (1)h-nmr spectral data. synthesized compounds were screened for antiviral activity against influenza a (h1n1, h3n2, h5n1) and influenz ... | 2009 | 20502550 |
| differences in the epidemiological characteristics and clinical outcomes of pandemic (h1n1) 2009 influenza, compared with seasonal influenza. | there are limited data comparing the clinical presentations, comorbidities, and outcomes of patients with infections due to seasonal influenza with patients with infections due to pandemic (h1n1) 2009 influenza. | 2010 | 20500086 |
| differing symptom patterns in early pandemic vs seasonal influenza infections. | singapore is a tropical country with a temperature range of 23 degrees c to 35 degrees c and relative humidity of 48% to 100% throughout the year. influenza incidence peaks in june through july and november through january, though influenza cases can be detected throughout the year. | 2010 | 20498413 |
| influenza vaccine effectiveness in primary school children in japan: a prospective cohort study using rapid diagnostic test results. | a low-cost, prospective cohort study using the results of rapid diagnostic test performed at local clinics was conducted to estimate influenza vaccine effectiveness (ve) in school children (6-12 year-olds). all children in four primary schools in tsuchiura city, ibaraki, japan were enrolled (n = 2607). vaccination status and other risk factors were obtained with a baseline questionnaire. participants were encouraged to visit a clinic to have a rapid test when they developed an influenza-like ill ... | 2010 | 20490595 |
| flutyper-an algorithm for automated typing and subtyping of the influenza virus from high resolution mass spectral data. | high resolution mass spectrometry has been employed to rapidly and accurately type and subtype influenza viruses. the detection of signature peptides with unique theoretical masses enables the unequivocal assignment of the type and subtype of a given strain. this analysis has, to date, required the manual inspection of mass spectra of whole virus and antigen digests. | 2010 | 20482883 |
| [development of single-tube multiplex real-time pcr for simultaneous detection of novel influenza a h1n1 and human seasonal influenza a h1n1 and h3n2 virus]. | in this study, we established a rapid and sensitive multiplex real-time reverse transcription polymerase chain reaction (mrtrt-pcr) to simultaneously detect the novel human influenza a h1n1 virus, human seasonal influenza a h1n1 and h3n2. this assay had three pairs of primer to target the conserved regions of the ha gene for each of the ha types including novel h1n1, seasonal h1n1 and seasonal h3n2, and one pair of primer designed to detect the internal control-rnasep gene. this assay was perfor ... | 2010 | 20480637 |
| [colorimetric detection of human influenza a h1n1 virus by reverse transcription loop mediated isothermal amplification]. | a simple, rapid and sensitive colorimetric reverse transcription loop mediated isothermal amplification (rt-lamp) method was established to detect human influenza a h1n1 virus. the method employed a set of six specially designed primers that recognized eight distinct sequences of the ha gene for amplification of nucleic acid under isothermal conditions at 65 degrees c for one and half hour. the amplification process of rt-lamp was monitored by the addition of hnb (hydroxy naphthol blue) dye prio ... | 2010 | 20480635 |
| tracking the emergence of pandemic influenza a/h1n1/2009 and its interaction with seasonal influenza viruses in singapore. | since the emergence of the pandemic influenza a/h1n1/2009 virus in april 2009, diagnostic testing in many countries has revealed the rapid displacement and then replacement of circulating seasonal influenza viruses by this novel virus. | 2010 | 20473453 |
| genetic sequence analysis of influenza viruses and illness severity in ill children previously vaccinated with live attenuated or inactivated influenza vaccine. | in a large comparative study in 2004-2005, children aged 6-59 months vaccinated with live attenuated influenza vaccine (laiv) experienced 55% fewer cases of culture-confirmed influenza illness compared with trivalent inactivated influenza vaccine (tiv) recipients. to better understand the characteristics of the breakthrough influenza illnesses, we analyzed the ha1 genetic sequence for all available samples and examined disease severity by strain and treatment group. all 48 a/h1n1 viruses were we ... | 2010 | 20472026 |
| failure of routine diagnostic methods to detect influenza in hospitalized older adults. | to define the utility of using routine diagnostic methods to detect influenza in older, hospitalized adults. | 2010 | 20470035 |
| [clinical trial of safety and immunogenicity of new influenza vaccine grifor in children]. | assessment of reactogenicity, safety and immunogenicity after single intramuscular immunization of children with grifor vaccine. | 2010 | 20465002 |
| influenza m2 proton channels. | m2 of the influenza virus is an intriguing transmembrane protein that forms a minuscule proton channel in the viral envelope. its recognized function is to equilibrate ph across the viral membrane during cell entry and across the trans-golgi membrane of infected cells during viral maturation. it is vital for viral replication and it is a target for the anti-influenza drugs, amantadine and rimantadine. recently, high resolution structures of m2 channels of both flu a and b have been obtained, pro ... | 2011 | 20451491 |
| development of multiplex nucleic acid sequence-based amplification for detection of human respiratory tract viruses. | a group of common lower respiratory tract infections, influenza a, influenza b, human parainfluenza virus 1-4 (hpiv1-4), respiratory syncytial virus (rsv), rubella virus (rv) and coxsackie virus (csv), were selected for the development of a multiplex nucleic acid sequence-based amplification (nasba) assay. quantifiable measurement utilizing an enzyme-linked oligonucleotide capture (eoc) optical detection method, which was described previously, alleviated the requirement of specialized instrument ... | 2010 | 20447419 |
| influenza immunization in pregnancy--antibody responses in mothers and infants. | 2010 | 20427817 | |
| [efficiency of seasonal influenza vaccine in persons older than 65 in romania. pilot case-control study i-move, 2008-2009]. | cantacuzino institute conducted between september 2008 and june 2009, a pilot case-control study to monitor the influenza vaccine effectiveness on people over 65 years of age from romania. this study is part of the i-move project "monitoring the vaccine effectiveness during seasonal and pandemic influenza in eu/eea member states, 2008-2009", coordinated by epiconcept, france and financed by european centre for disease prevention and control (ecdc), stockholm, sweden. forty seven family doctors a ... | 2009 | 20422925 |
| clinical attack rate and presentation of pandemic h1n1 influenza versus seasonal influenza a and b in a pediatric cohort in nicaragua. | background. little is known about the clinical presentation and epidemiology of influenza a h1n1pdm in children in developing countries. we assessed the severity of influenza a h1n1pdm in children in nicaragua by comparing h1n1pdm cases to seasonal influenza cases in an ongoing cohort study. methods. the nicaraguan influenza cohort study was established in june 2007 to study the burden and seasonality of pediatric influenza in a tropical developing country. during the period from june 2007 throu ... | 2010 | 20420502 |
| portrait of a year-old pandemic. | 2010 | 20414281 | |
| narcissus tazetta lectin shows strong inhibitory effects against respiratory syncytial virus, influenza a (h1n1, h3n2, h5n1) and b viruses. | a mannose-binding lectin (narcissus tazetta lectin [ntl]) with potent antiviral activity was isolated and purified from the bulbs of the chinese daffodil narcissus tazetta var. chinensis, using ion exchange chromatography on diethylaminoethyl (deae)-cellulose, affinity chromatography on mannose-agarose and fast protein liquid chromatography (fplc)-gel filtration on superose 12. the purified lectin was shown to have an apparent molecular mass of 26 kda by gel filtration and 13 kda by sds-page, in ... | 2010 | 20413914 |
| the immunogenicity of intradermal influenza vaccination in copd patients. | we evaluated the immunogenicity of a reduced-dose intradermal trivalent, inactivated, split-virion seasonal influenza vaccine compared to that of a conventional intramuscular vaccination in chronic obstructive pulmonary disease (copd) patients. one hundred and fifty-six copd patients randomly received either 0.2 ml (6 microg hemagglutinin (ha) per strain) split into two-site intradermal (id) injections or a single 0.5 ml (15 microg ha per strain) intramuscular (im) injection. geometric mean tite ... | 2010 | 20412877 |
| influenza outbreaks during world youth day 2008 mass gathering. | influenza outbreaks during mass gatherings have been rarely described, and detailed virologic assessment is lacking. an influenza outbreak occurred during world youth day in sydney, australia, july 2008 (wyd2008). we assessed epidemiologic data and respiratory samples collected from attendees who sought treatment for influenza-like illness at emergency clinics in sydney during this outbreak. isolated influenza viruses were compared with seasonal influenza viruses from the 2008 influenza season. ... | 2010 | 20409371 |
| update: influenza activity - united states, august 30, 2009-march 27, 2010, and composition of the 2010-11 influenza vaccine. | the emergence and spread of 2009 pandemic influenza a (h1n1) virus resulted in substantial influenza activity in the united states throughout the summer and fall months of 2009, with activity peaking in late october. activity declined beginning in november 2009 but continued at lower levels through march 2010. the 2009 h1n1 virus remained the dominant circulating influenza virus throughout the season; <1% of characterized viruses were seasonal influenza a (h1), a (h3), and influenza b viruses. t ... | 2010 | 20395936 |
| a randomized controlled trial of low-dose recombinant human interferons alpha-2b nasal spray to prevent acute viral respiratory infections in military recruits. | the military population has a high disease burden of acute viral respiratory infections in china. to assess the efficacy and safety of a low-dose recombinant human interferon alpha-2b (rifnalpha-2b) nasal spray in preventing acute viral respiratory infections in military population, we performed this randomized controlled trial. the results showed that application of the rifnalpha-2b nasal spray had the benefits in prevention of infections caused by influenza a virus, influenza b virus parainflu ... | 2010 | 20394720 |
| viral shedding and clinical illness in naturally acquired influenza virus infections. | volunteer challenge studies have provided detailed data on viral shedding from the respiratory tract before and through the course of experimental influenza virus infection. there are no comparable quantitative data to our knowledge on naturally acquired infections. | 2010 | 20377412 |
| immunogenicity and safety of intradermal influenza vaccination in healthy older adults. | influenza vaccine immunogenicity is suboptimal in older persons. intradermal (id) vaccination may be a promising alternative to intramuscular (im) vaccination. | 2010 | 20377407 |
| long-acting neuraminidase inhibitor laninamivir octanoate (cs-8958) versus oseltamivir as treatment for children with influenza virus infection. | we conducted a double-blind, randomized controlled trial to compare a long-acting neuraminidase inhibitor, laninamivir octanoate, with oseltamivir. eligible patients were children 9 years of age and under who had febrile influenza symptoms of no more than 36-h duration. patients were randomized to 1 of 3 treatment groups: a group given 40 mg laninamivir (40-mg group), a group given 20 mg laninamivir (20-mg group), and an oseltamivir group. laninamivir octanoate was administered as a single inhal ... | 2010 | 20368393 |
| limited compatibility of polymerase subunit interactions in influenza a and b viruses. | despite their close phylogenetic relationship, natural intertypic reassortants between influenza a (flua) and b (flub) viruses have not been described. inefficient polymerase assembly of the three polymerase subunits may contribute to this incompatibility, especially because the known protein-protein interaction domains, including the pa-binding domain of pb1, are highly conserved for each virus type. here we show that substitution of the flua pa-binding domain (pb1-a(1-25)) with that of flub (p ... | 2010 | 20363752 |
| development of a multiplex real-time rt-pcr assay for detection of influenza a, influenza b, rsv and typing of the 2009-h1n1 influenza virus. | a high-throughput real-time rt-pcr assay was developed to amplify and detect a conserved region of the hemagglutinin gene of the 2009-h1n1 influenza a virus using a minor groove binder-conjugated hybridization probe. the assay was paired with a separate triplex real-time assay that detects influenza a via the matrix gene, influenza b and rsv in a multiplex format and compared with the centers for disease control and prevention (cdc) rrt-pcr assay using 143 samples. the 2009-h1n1 portion of the m ... | 2010 | 20362006 |
| lethal influenza b myocarditis in a child and review of the literature for pediatric age groups. | we report on the case of a 5 year-old girl who developed fulminant myocarditis due to acute infection with influenza virus type b. cardiac arrest occurred suddenly, resuscitation efforts were not successful, and the patient died of congestive heart failure 24 h after admission to the hospital. | 2010 | 20358246 |
| the epidemiology of hospitalized influenza in children, a two year population-based study in the people's republic of china. | the epidemiology and disease burden of annual influenza in children in mainland people's republic of china have not been reported in detail. to understand the incidence and epidemiology of laboratory-proven influenza hospitalization in children in china, a review of available laboratory and hospital admission data was undertaken. | 2010 | 20353557 |
| in vitro antiviral activity of favipiravir (t-705) against drug-resistant influenza and 2009 a(h1n1) viruses. | favipiravir (t-705) has previously been shown to have a potent antiviral effect against influenza virus and some other rna viruses in both cell culture and in animal models. currently, favipiravir is undergoing clinical evaluation for the treatment of influenza a and b virus infections. in this study, favipiravir was evaluated in vitro for its ability to inhibit the replication of a representative panel of seasonal influenza viruses, the 2009 a(h1n1) strains, and animal viruses with pandemic (pd ... | 2010 | 20350949 |
| dual seasonal patterns for influenza, china. | 2010 | 20350403 | |
| respiratory virus pneumonia after hematopoietic cell transplantation (hct): associations between viral load in bronchoalveolar lavage samples, viral rna detection in serum samples, and clinical outcomes of hct. | few data exist on respiratory virus quantitation in lower respiratory samples and detection in serum from hematopoietic cell transplant (hct) recipients with respiratory virus-associated pneumonia. | 2010 | 20350162 |
| performance of rapid influenza testing in hospitalized children. | influenza infection is associated with high hospitalization rates among young children. rapid diagnosis of influenza infection is particularly useful in order to prevent nosocomial infection and allows for the timely initiation of antiviral treatment. we evaluated the performance of a rapid influenza test in hospitalized children during the influenza season. all children (aged 6 months to 14 years) hospitalized with fever and/or respiratory symptoms, admitted during the 2005 influenza season, pa ... | 2010 | 20349200 |
| influenza b; study of a localized outbreak preceding the 1945 epidemic. | 1947 | 20341907 | |
| [hemorrhagic lesion of the corpus callosum in influenza-associated encephalitis]. | we describe a rare case of influenza b-associated encephalopathy with hemorrhagic lesions of the corpus callosum. a 12-year-old caucasian girl presented a 24-h fever followed by partial seizure, secondarily generalized, and disturbance of consciousness. magnetic resonance imaging on day 2 of her illness showed two hemorrhagic lesions of the corpus callosum. the influenza b virus was found on nasopharyngeal swab. neurologic signs had completely recovered by day 3. a review of the literature ident ... | 2010 | 20338734 |
| lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections. | virus-infected cells secrete a broad range of interferons (ifn) which confer resistance to yet uninfected cells by triggering the synthesis of antiviral factors. the relative contributions of the various ifn subtypes to innate immunity against virus infections remain elusive. ifn-alpha, ifn-beta, and other type i ifn molecules signal through a common, universally expressed cell surface receptor, whereas type iii ifn (ifn-lambda) uses a distinct cell-type-specific receptor complex for signaling. ... | 2010 | 20335250 |
| a two-tiered model for simulating the ecological and evolutionary dynamics of rapidly evolving viruses, with an application to influenza. | understanding the epidemiological and evolutionary dynamics of rapidly evolving pathogens is one of the most challenging problems facing disease ecologists today. to date, many mathematical and individual-based models have provided key insights into the factors that may regulate these dynamics. however, in many of these models, abstractions have been made to the simulated sequences that limit an effective interface with empirical data. this is especially the case for rapidly evolving viruses in ... | 2010 | 20335193 |
| acute respiratory infections in children: i. an intensive study of etiology in an open community. | during a seven-month period from november 1960 to may 1961, 181 infants and children, hospitalized because of acute respiratory infections, were studied intensively to determine the responsible etiologic agents. forty-two per cent of the illnesses in this group appeared to be caused by bacterial agents, either primary or secondary to virus. parainfluenza viruses were identified as causes of laryngotracheobronchitis in nearly 50% of the cases. adenoviruses were also found to be important pathogen ... | 1963 | 20327546 |
| myxovirus infections in acute laryngotracheobronchitis, toronto, 1961-62. | virological investigations were undertaken on nasopharyngeal secretions from 186 children who were admitted to the hospital for sick children, toronto, with acute laryngotracheobronchitis between december 1961 and march 1962. patients who required tracheotomy for relief of respiratory obstruction were excluded from this series. myxoviruses which were isolated from 47 patients included the following antigenic types: 29 parainfluenza-1, four parainfluenza-2, five parainfluenza-3 and nine influenza ... | 1962 | 20327304 |
| simultaneous typing and ha/na subtyping of influenza a and b viruses including the pandemic influenza a/h1n1 2009 by multiplex real-time rt-pcr. | pandemic influenza a/h1n1 2009 and seasonal influenza viruses are currently co-circulating worldwide. a rapid, sensitive, and specific assay for distinguishing pandemic influenza a/h1n1 2009 from seasonal influenza viruses and for subtyping seasonal influenza a viruses could aid in the surveillance and control of these viral infections. here, such a multiplex real-time rt-pcr (rrt-pcr) assay for typing influenza a and b viruses and the pandemic influenza a/h1n1 2009 is developed. this assay can ... | 2010 | 20304017 |
| [seasonal flu]. | seasonal flu is caused by influenza viruses a and b. these enveloped viruses have a genome made up of seven or eight rna fragments. the different subtypes are determined by the nature of the two surface glycoproteins ha and na. seasonal flu is an epidemic wintertime illness occurring in temperate climate zones. its epidemiology is linked to the great variability of the virus in time, necessitating an alert system that detects dominating circulating variants each year and that determines the vacc ... | 2010 | 20303676 |
| influenza b in needham, massachusetts, december, 1945; serologic studies in cases and in family contacts. | 1947 | 20293026 | |
| the protective effect of vaccination against epidemic influenza b in an industrial plant. | 1947 | 20285177 | |
| a study of an outbreak of influenza b in rochester, new york. | 1947 | 20283822 | |
| the effect of vaccination on the incidence of influenza b. | 1947 | 20279330 | |
| infections of the nervous system occurring during an epidemic of influenza b. | 1946 | 20277507 | |
| 1945 influenza b epidemic in the pacific area. | 1946 | 20276811 | |
| serological response to influenza b infection in human beings; differentiation of specific and nonspecific type reactions. | 1946 | 20273976 | |
| observations on an epidemic of influenza b occurring at the johns hopkins hospital in november-december, 1945. | 1947 | 20268505 | |
| influenza b; study of a localized outbreak preceding the 1945 epidemic. | 1946 | 20248527 | |
| an outbreak of influenza b infection; epidemiologic observations. | 1947 | 20241258 | |
| safety, efficacy, and immunogenicity of an inactivated influenza vaccine in healthy adults: a randomized, placebo-controlled trial over two influenza seasons. | seasonal influenza imposes a substantial personal morbidity and societal cost burden. vaccination is the major strategy for influenza prevention; however, because antigenically drifted influenza a and b viruses circulate annually, influenza vaccines must be updated to provide protection against the predicted prevalent strains for the next influenza season. the aim of this study was to assess the efficacy, safety, reactogenicity, and immunogenicity of a trivalent inactivated split virion influenz ... | 2010 | 20236548 |
| controversies in vaccine mandates. | policies that mandate immunization have always been controversial. the controversies take different forms in different contexts. for routine childhood immunizations, many parents have fears about both short- and long-term side effects. parental worries change as the rate of vaccination in the community changes. when most children are vaccinated, parents worry more about side effects than they do about disease. because of these worries, immunization rates go down. as immunization rates go down, d ... | 2010 | 20230978 |
| assessing the burden of paediatric influenza in europe: the european paediatric influenza analysis (epia) project. | the european paediatric influenza analysis (epia) project is a multi-country project that was created to collect, analyse and present data regarding the paediatric influenza burden in european countries, with the purpose of providing the necessary information to make evidence-based decisions regarding influenza immunisation recommendations for children. the initial approach taken is based on existing weekly virological and age-specific influenza-like illness (ili) data from surveillance networks ... | 2010 | 20229049 |
| species-specific antagonism of host isgylation by the influenza b virus ns1 protein. | interferon-stimulated expression and conjugation of the ubiquitin-like modifier isg15 restricts replication of several viruses. here, we established complete e1-activating, e2-conjugating, and e3 ligase-dependent expression systems for assaying both human and mouse isgylation. we confirm that human herc5, but not human herc6, has isg15 e3 ligase activity and identify mouse herc6 as a bona fide isg15 e3 ligase. furthermore, we demonstrate that influenza b virus ns1 protein potently antagonizes hu ... | 2010 | 20219937 |
| effect of influenza vaccination of children on infection rates in hutterite communities: a randomized trial. | children and adolescents appear to play an important role in the transmission of influenza. selectively vaccinating youngsters against influenza may interrupt virus transmission and protect those not immunized. | 2010 | 20215608 |
| oseltamivir in seasonal influenza: cumulative experience in low- and high-risk patients. | seasonal influenza viruses cause annual disease epidemics that affect individuals at low and high risk for secondary illnesses. influenza vaccines are widely used in high-risk patients to prevent infection, but the protection afforded varies by population; uptake is also limited in some groups. antiviral drugs for influenza are now readily available. oseltamivir is the most widely used antiviral for the treatment and prophylaxis of seasonal influenza, and its efficacy and safety are now well est ... | 2010 | 20215131 |
| recommended viruses for influenza vaccines for use in the 2010-2011 northern hemisphere influenza season. | 2010 | 20210260 | |
| immunogenicity of trivalent influenza vaccine in children with acute lymphoblastic leukemia during maintenance therapy. | the aim of this study was to assess the immune response of children with acute lymphoblastic leukemia (all) to influenza vaccine and to compare it with healthy controls. | 2010 | 20205258 |
| [in vitro investigation of ingavirin efficacy against influenza b virus]. | the experimental investigation of ingavirin activity against influenza b virus showed that in concentrations 100 and 200 mcg/ml it was efficient in inhibition of the virus reproduction: the cytopathic effect was lowered by 75%, the level of the pathogen accumulation in the mdck cell culture was decreased by more than 2.0 lg and the formation of the virus specific hemagglutinin was inhibited by more than 90%. | 2009 | 20201397 |
| a family of non-classical pseudoknots in influenza a and b viruses. | a very conserved pseudoknot structure has been shown to fold in influenza virus rna. the pseudoknot encompasses the 3' splice site of segment 8 rna in both influenza a and b viruses. by sequence comparison of influenza virus strains, we derive a consensus motif that defines a novel rna pseudoknot family. the orientation of the coaxially stacked stems in the influenza pseudoknot differs from that in classical h-pseudoknots. apart from the size of the loops, the topology of the influenza pseudokno ... | 2010 | 20200490 |
| shift in oligosaccharide specificities of hemagglutinin and neuraminidase of influenza b viruses resistant to neuraminidase inhibitors. | influenza virus neuraminidase inhibitors (nais), currently used as anti-influenza drugs, can lead to the appearance of drug-resistant variants. resistance to nais appears due to mutations in the active site of the neuraminidase (na) molecule that decrease the na enzymatic activity and sometimes in the hemagglutinin (ha) that decrease its affinity for cell receptors and, therefore, reduce the requirement for na activity in releasing mature virions from infected cells. using a set of sialo-oligosa ... | 2010 | 20195900 |
| antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza a and b virus replication. | influenza viruses of types a and b cause periodic pandemics in the human population. the antiviral drugs approved to combat influenza virus infections are currently limited. we have investigated an effective novel inhibitor of human influenza a and b viruses, triazavirine [2-methylthio-6-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazine-7(4i)-one] (tzv). tzv suppressed the replication of influenza virus in cell culture and in chicken chorioallantoic membranes, and it protected mice from death caused by ... | 2010 | 20194696 |
| novel inhibitors of influenza virus fusion: structure-activity relationship and interaction with the viral hemagglutinin. | a new class of n-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide inhibitors of influenza virus hemagglutinin (ha)-mediated membrane fusion that has a narrow and defined structure-activity relationship was identified. in madin-darby canine kidney (mdck) cells infected with different strains of human influenza virus a/h3n2, the lead compound, 4c, displayed a 50% effective concentration of 3 to 23 mum and an antiviral selectivity index of 10. no activity was observed for a/h1n1, a/h5n1, a/h7n2, and b ... | 2010 | 20181685 |
| effects of influenza immunization on humoral and cellular alloreactivity in humans. | alloreactive t cells and anti-human leukocyte antigen antibodies mediate transplant injury. environmental exposures, including vaccinations, may activate the alloimmune repertoire leading to accelerated allograft injury. to test whether vaccination impacts human alloimmunity, we analyzed humoral and cellular immune reactivity in subjects undergoing influenza vaccination. | 2010 | 20179666 |
| an early report from newly established laboratory-based influenza surveillance in lao pdr. | prior to 2007, little information was available about the burden of influenza in laos. we report data from the first laboratory-based influenza surveillance system established in the lao people's democratic republic. | 2010 | 20167044 |
| immunological effect of subunit influenza vaccine entrapped by liposomes. | to elevate the immunological effect of subunit influenza vaccine in infants and aged people (over 60) using liposomal adjuvant in the context of its relatively low immunity and to investigate the relation between vaccine antigens and liposomal characteristics. | 2009 | 20163063 |
| household transmissibility and other characteristics of seasonal oseltamivir-resistant influenza a(h1n1) viruses, germany, 2007-8. | during the influenza season 2007-8, the proportion of seasonal influenza a(h1n1) viruses resistant to the neuraminidase inhibitor oseltamivir increased worldwide. we conducted an investigation to compare patients infected with oseltamivir-resistant (ose-r) and oseltamivir- susceptible (ose-s) influenza a(h1n1) viruses regarding risk factors for resistance and the capability to transmit in the household setting. within a cohort of 396 laboratory confirmed influenza patients from sentinel physicia ... | 2010 | 20158979 |
| usefulness of two new methods for diagnosing metapneumovirus infections in children. | human metapneumovirus (hmpv) is associated with acute respiratory tract infections, mainly in paediatric patients. the aim of this study was to evaluate the usefulness of two new commercial techniques available for the detection of hmpv in clinical samples from children: an enzyme immunoassay, hmpv eia (biotrin international ltd), and a molecular assay, real-time rt-pcr (pro hmpv real time assay kit; prodesse). a total of 184 nasopharyngeal aspirate specimens from 173 children aged less than 5 y ... | 2010 | 20156218 |
| evaluation of southern hemisphere influenza vaccine recommendations. | in 1999, the world health organization switched from annual to semi-annual recommendations for influenza vaccine composition. we compared the antigenic match between recommendations and circulating viruses before and after 1999, in the northern and southern hemispheres. vaccine match proportion for a/h3n2 viruses increased from 31% to 59% in the southern hemisphere (p<0.05), and is now comparable to that in the northern hemisphere. vaccine match for influenza b decreased from approximately 100% ... | 2010 | 20153352 |
| transient oligoarthritis of the lower extremity following influenza b virus infection: case report. | a 12-year-old girl developed influenza b virus infection proven by typical symptoms and detection of the virus in a nasopharyngeal swab by culture and pcr. two weeks later she developed an otherwise unexplained transient oligoarthritis of small joints of the left foot. influenza viruses may be a hitherto underappreciated cause of a post-infectious arthritis. | 2010 | 20148144 |
| stimulation of protective and cross-protective immunity against influenza b virus after adjuvant mucosal immunization of mice. | intratracheal immunization of mice with inactivated influenza b virus and delipidated bacillus firmus as adjuvant increases protection of mice against infection with the homologous virus strain and induces cross-protection: mice immunized by influenza virus b/yamanashi 166/98 were protected even against phylogenetically distant virus drift variant b/lee/40 lethal for mice. | 2010 | 20140725 |
| respiratory viral rna on toys in pediatric office waiting rooms. | toys in pediatric office waiting rooms may be fomites for transmission of viruses. | 2010 | 20135827 |
| surveillance of influenza virus b circulation in northern italy: summer-fall 2008 isolation of three strains and phylogenetic analysis. | influenza virus type b strains were unexpectedly detected and isolated in italy during summer-fall 2008 from three patients travelling to italy from lebanon, senegal and uzbekistan. the three summer-fall strains matched to a high degree the hemagglutinin (ha1) of influenza virus type b strains circulating in italy in the second part (january through april) of the 2007/2008 season, and ha1 of the type b strains included in the 2008/2009 vaccine (b/yamagata/16/88 lineage). surveillance of influenz ... | 2009 | 20128448 |
| a review of the dynamics and severity of the pandemic a(h1n1) influenza virus on réunion island, 2009. | on reunion island, in response to the threat of emergence of the pandemic influenza a(h1n1)2009 virus, we implemented enhanced influenza surveillance from may 2009 onwards in order to detect the introduction of pandemic h1n1 influenza and to monitor its spread and impact on public health. the first 2009 pandemic influenza a(h1n1) virus was identified in réunion on july 5, 2009, in a traveller returning from australia; seasonal influenza b virus activity had already been detected. by the end of j ... | 2010 | 20121825 |
| serological response to influenza vaccine after hematopoetic stem cell transplantation. | vaccination is the best strategy to prevent influenza infection that is a potential cause of morbidity and mortality in immunosuppressed patients. here, we evaluated the factors that may affect serological response to influenza vaccine in patients who have undergone hematopoetic stem cell transplantation (hsct). sixty-one hsct recipients were included in the study during the 2007-2008 influenza season. serum samples prior to vaccination and 6-10 weeks after vaccination were collected. samples we ... | 2010 | 20119669 |
| influenza vaccines: from surveillance through production to protection. | influenza is an important contributor to population and individual morbidity and mortality. the current influenza pandemic with novel h1n1 has highlighted the need for health care professionals to better understand the processes involved in creating influenza vaccines, both for pandemic as well as for seasonal influenza. this review presents an overview of influenza-related topics to help meet this need and includes a discussion of the burden of disease, virology, epidemiology, viral surveillanc ... | 2010 | 20118381 |
| typing of human and animal strains of influenza virus with conserved signature peptides of matrix m1 protein by high resolution mass spectrometry. | the use of high resolution mass spectrometry to detect signature peptides within proteolytic digests of the isolated matrix m1 protein, and whole virus digests, for both human and animal strains of influenza is shown to be able to rapidly and reliably type the virus. conserved sequences for predicted tryptic peptides were identified through alignments of matrix m1 protein sequences across all human, avian and swine strains of the influenza virus. peptides with unique masses, when compared with t ... | 2010 | 20117137 |
| immunogenicity and tolerability of a virosome influenza vaccine compared to split influenza vaccine in patients with sickle cell anemia. | the immunogenicity and tolerability of virosome and of split influenza vaccines in patients with sickle cell anemia (ss) were evaluated. ninety ss patients from 8 to 34 years old were randomly assigned to receive either virosome (n=43) or split vaccine (n=47). two blood samples were collected, one before and one 4-6 weeks after vaccination. antibodies against viral strains (2006) a/new caledonia (h1n1), a/california (h3n2), b/malaysia were determined using the hemagglutinin inhibition test. post ... | 2010 | 20116631 |
| [viral etiology of acute respiratory infection in children from wenzhou between 2007 and 2008]. | to study the viral etiology of acute respiratory infection (ari)in children from wenzhou, zhejiang between 2007 and 2008. | 2010 | 20113631 |
| epidemiology of seasonal, avian and pandemic influenza. | 2009 | 20112827 | |
| high dose immune globulin therapy ameliorates peripartum cardiomyopathy with elevated serum antibody titer to influenza virus: case report of two patients. | peripartum cardiomyopathy (ppcm) is a rare complication characterized by heart failure that arises between the last month of pregnancy and the first 5 months after delivery. the etiology of this disorder has not been clarified due to its low incidence. we describe two patients with ppcm and elevated antibody titers to influenza virus in paired sera that were recovered by high doses of intravenous immune globulin. | 2010 | 20110922 |
| [mortality associated with peak seasons of influenza virus circulation in bogotá, colombia, 1997-2005]. | to estimate potential excess mortality attributable to influenza viruses a and b and human respiratory syncytial virus (hrsv) during peak seasons of influenza virus circulation in colombia from 1997 to 2005. | 2009 | 20107695 |
| differentiation of influenza b virus lineages yamagata and victoria by real-time pcr. | since the 1970s, influenza b viruses have diverged into two antigenically distinct virus lineages called the yamagata and victoria lineages. we present the first real-time pcr assay for virus lineage differentiation to supplement classical antigenic analyses. the assay was successfully applied to 310 primary samples collected in germany from 2007 to 2009. | 2010 | 20107085 |
| exercise intensity does not influence the efficacy of eccentric exercise as a behavioural adjuvant to vaccination. | acute exercise prior to vaccination can improve the antibody response to influenza vaccination. however, both the optimal exercise protocol and the mechanisms underpinning this adjuvant effect remain unclear. the aim of the current study was to determine whether exercise intensity influenced the efficacy of the intervention. one hundred and sixty healthy young adults were randomly assigned to a resting control group or one of three intervention groups, who exercised at an intensity of 60%, 85%, ... | 2010 | 20102734 |
| distribution of airborne influenza virus and respiratory syncytial virus in an urgent care medical clinic. | considerable controversy exists with regard to whether influenza virus and respiratory syncytial virus (rsv) are spread by the inhalation of infectious airborne particles and about the importance of this route, compared with droplet or contact transmission. | 2010 | 20100093 |
| comparison between a conventional subunit vaccine and the mf59-adjuvanted subunit influenza vaccine in the elderly: an evaluation of the safety, tolerability and immunogenicity. | the objective of this study was to evaluate and compare the safety, tolerability and immunogenicity for two seasonal influenza subunit vaccines, one with mf59 adjuvant (fluad) and one without an adjuvant (agrippal). a total of 195 subjects aged > or = 65 years were enrolled to receive one dose of vaccine intramuscularly, 96 were vaccinated with fluad, 99 received agrippal. blood samples were taken from all subjects in order to assess their antibody titre by the haemagglutination inhibition assay ... | 2009 | 20099444 |
| [collapse of a competitive athlete at a competition - case 1/2010. myocarditis]. | 2010 | 20099382 | |
| species specificity of the ns1 protein of influenza b virus: ns1 binds only human and non-human primate ubiquitin-like isg15 proteins. | influenza b viruses, which cause a highly contagious respiratory disease every year, are restricted to humans, but the basis for this restriction had not been determined. here we provide one explanation for this restriction: the species specificity exhibited by the ns1 protein of influenza b virus (ns1b protein). this viral protein combats a major host antiviral response by binding the interferon-alpha/beta-induced, ubiquitin-like isg15 protein and inhibiting its conjugation to an array of prote ... | 2010 | 20093371 |
| anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives. | by using a cell-based high throughput screening campaign, a novel angelicin derivative 6a was identified to inhibit influenza a (h1n1) virus induced cytopathic effect in madin-darby canine kidney cell culture in low micromolar range. detailed structure-activity relationship studies of 6a revealed that the angelicin scaffold is essential for activity in pharmacophore b, while meta-substituted phenyl/2-thiophene rings are optimal in pharmacophore a and c. the optimized lead 4-methyl-9-phenyl-8-(th ... | 2010 | 20092255 |
| [analysis on surveillance of influenza in tianshui prefecture from 2005 to 2008]. | to observe epidemic status and the types of the influenza virus, to analyse influenza epidemic trends in tianshui city, and to provide basis for influenza prevention and control. | 2009 | 20084889 |
| [evaluation on the safety and immunogenicity of split influenza virus vaccine]. | to evaluate the safety and immunogenicity of split influenza virus vaccine made in changchun institute of biological products. | 2009 | 20084888 |
| [influenza surveillance by molecular diagnosis]. | our objective was to evaluate the application of molecular techniques in the surveillance of influenza, and to describe clinical and epidemiological characteristics of cases diagnosed in 2007-2008 and 2008-2009 seasons. | 2009 | 20082043 |
| viral agents responsible for febrile respiratory illnesses among military recruits training in tropical singapore. | military personnel are highly susceptible to febrile respiratory illnesses (fri), likely due to crowding, stress and other risk factors present in the military environment. | 2010 | 20079688 |
| [virological surveillance and molecular characteristics of influenza b viruses in hebei province during 2004-2008]. | to understand influenza b viruses circulating and antigenic variation and distributing in hebei province during 2004-2008. | 2009 | 20077671 |
| [the meta analysis on the safety and immunogenicity of domestic and imported split influenza virus vaccines]. | to compare the safety and immunogenicity between domestic and imported, imported and imported split influenza virus vaccine in chinese population. | 2009 | 20077670 |
| comparative efficacy of influenza vaccines. | 2010 | 20077593 | |
| comparative efficacy of influenza vaccines. | 2010 | 20071712 | |
| duplex real-time reverse transcriptase pcr assays for rapid detection and identification of pandemic (h1n1) 2009 and seasonal influenza a/h1, a/h3, and b viruses. | reports of a novel influenza virus type a (h1n1), now designated by the world health organization as pandemic (h1n1) 2009, emerged from the united states and mexico in april 2009. the management of the pandemic in australia required rapid and reliable testing of large numbers of specimens for the novel influenza strain and differentiation from seasonal influenza strains. a real-time reverse transcriptase pcr (rt-pcr) assay for the detection of pandemic (h1n1) 2009 was designed and used with exis ... | 2010 | 20071557 |