Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| epstein-barr virus associated with a lymphoma-mimicking lesion of the uterine cervix. | 2016 | 27769038 | |
| receptor tyrosine kinase amplified gastric cancer: clinicopathologic characteristics and proposed screening algorithm. | although targeted therapy for receptor tyrosine kinases (rtks) of advanced gastric cancers (agcs) has been in the spotlight, guidelines for the identification of rtk-amplified gastric cancers (ra-gcs) have not been established. in this study, we investigate clinicopathologic characteristics of ra-gcs and propose a screening algorithm for their identification. we performed immunohistochemistry (ihc) for mlh1, msh2, pms2, msh6, key rtks (egfr, her2, met), and p53, in situ hybridization for epstein ... | 2016 | 27765925 |
| mva vaccine encoding cmv antigens safely induces durable expansion of cmv-specific t cells in healthy adults. | attenuated poxvirus modified vaccinia ankara (mva) is a useful viral-based vaccine for clinical investigation, because of its excellent safety profile and property of inducing potent immune responses against recombinant (r) antigens. we developed triplex by constructing an rmva encoding 3 immunodominant cytomegalovirus (cmv) antigens, which stimulates a host antiviral response: ul83 (pp65), ul123 (ie1-exon4), and ul122 (ie2-exon5). we completed the first clinical evaluation of the triplex vaccin ... | 2017 | 27760761 |
| [chronic active epstein-barr virus enteritis: report of a case]. | 2016 | 27760621 | |
| cervical viral infections among asymptomatic bulgarian women. | although sexually transmitted viral infections are significant and increasing public health concern, little is known about their prevalence among bulgarian women. the aim of this study was to investigate cervical viral infections in asymptomatic women. | 2016 | 27760284 |
| mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the lymphoma study association. | mediastinal gray zone lymphoma, b-cell lymphomas with intermediate features between classical hodgkin lymphoma and primary mediastinal b-cell lymphoma, have not been well described in the literature. we report the clinical characteristics and outcomes of a large retrospective series of 99 cases centrally reviewed by a panel of hematopathologists, with a consensus established for the diagnosis. cases were defined as classical hodgkin lymphoma-like morphology (64.6%) with primary mediastinal b-cel ... | 2017 | 27758822 |
| tax1bp1 downregulation by ebv-mir-bart15-3p enhances chemosensitivity of gastric cancer cells to 5-fu. | micrornas (mirnas) are a class of noncoding rna molecules approximately 19 to 25 nucleotides in length that downregulate the expression of target genes at the post-transcriptional level by binding to the 3'-untranslated region (3'-utr). epstein-barr virus (ebv) generates at least 44 mirnas, but the functions of most of these mirnas have not yet been identified. previously, we reported bruce as a target of mir-bart15-3p, a mirna produced by ebv, but our data suggested that there might be other ap ... | 2017 | 27757686 |
| effectiveness of preemptive therapy for cytomegalovirus disease in pediatric liver transplantation. | most pediatric liver transplantation (lt) centers administer long courses of prophylaxis against cytomegalovirus (cmv) without evidence of benefit and with significant drug exposure and costs. we aimed at evaluating overall outcomes, direct and putative indirect effects of cmv, possible impact of viremia and risk factors for cmv infection in pediatric lt recipients managed with ganciclovir-based preemptive therapy (pet). | 2017 | 27755504 |
| epstein-barr virus associated lymphomas in people with hiv. | the present review summarizes the association of the different histotypes of epstein-barr virus (ebv)-associated lymphomas with known genetic lesions and/or oncogenic viruses. a more comprehensive understanding of the complex interplay existing between genetic abnormalities of tumor cells and the viral contribution to the development of ebv-associated lymphomas is pivotal for the development of more effective treatments. | 2017 | 27755151 |
| distinguishing between hepatosplenic t-cell lymphoma and γδ t-cell large granular lymphocytic leukemia: a clinicopathologic, immunophenotypic, and molecular analysis. | hepatosplenic t-cell lymphoma (hstcl) is a rare, aggressive t-cell lymphoma that can be challenging to diagnose. in particular, distinguishing hstcl from t-cell large granular lymphocytic (t-lgl) leukemia of γδ t-cell receptor (tcr) type is difficult without examination of a splenectomy specimen. in this study, we systematically assessed a series of hstcl cases for findings reported in the literature as supporting or not supporting the diagnosis of hstcl. we also compared hstcl with a group of c ... | 2017 | 27755009 |
| cd56(-) extranodal natural killer (nk)/t-cell lymphoma, nasal type presenting as skin ulcers in a white man. | 2016 | 27752533 | |
| [panuveitis with oral and genital ulcer misdiagnosed as behcet's disease: two cases report and literature review]. | here we reported two patients who presented with panuveitis and were transferred from ophthalmologists to rheumatologists, for both the patients had oral and genital ulcers. they were misdiagnosed with behcet's disease at first glance. two young males presented with acute uveitis with history of recurrent oral and genital ulcers. they initially presented with symptoms and signs resembling behcet's disease and were treated with systemic steroids with suboptimal responses. routine laboratory test ... | 2016 | 27752180 |
| constitutive activation of t cells by γ2-herpesviral gpcr through the interaction with cellular cxcr4. | members of the herpesviral family use multiple strategies to hijack infected host cells and exploit cellular signaling for their pathogenesis and latent infection. among the most intriguing weapons in the arsenal of pathogenic herpesviruses are the constitutively active virally-encoded g protein-coupled receptors (vgpcrs). even though vgpcrs contribute to viral pathogenesis such as immune evasion and proliferative disorders, the molecular details of how vgpcrs continuously activate cellular sign ... | 2017 | 27751885 |
| karyotypic abnormalities associated with epstein-barr virus status in classical hodgkin lymphoma. | classical hodgkin lymphoma (chl) is morphologically characterized by scattered malignant hodgkin/reed-sternberg (hrs) cells that are far outnumbered by surrounding reactive hematolymphoid cells. approximately half of all cases of chl are associated with infection by epstein-barr virus (ebv), an oncogenic herpesvirus that expresses a number of proteins thought to contribute to transformation. while a small number of published studies have attempted to identify recurrent cytogenetic abnormalities ... | 2016 | 27751359 |
| the impact of ebv and hiv infection on the microenvironmental niche underlying hodgkin lymphoma pathogenesis. | the pathogenesis of classical hodgkin lymphoma (chl) is still enigmatic, largely because its tumor cells, the so-called hodgkin and reed-stenberg (hrs) cells, invariably reside in a prominent reactive microenvironment, are rare and therefore difficult to analyze. on the other hand, the broadly investigated chl-derived cell lines are not unequivocally considered as suitable and representative models for this puzzling disease. based on current knowledge, it appears that the cross talk between the ... | 2017 | 27750386 |
| acute liver failure: outcome and value of pediatric end-stage liver disease score in pediatric cases. | the aims of this study were to analyze the characteristics of patients with acute liver failure (alf) in our center and evaluate the prognostic value of the pediatric end-stage liver disease (peld) score calculated at admission. | 2016 | 27749626 |
| epstein-barr virus dna level as a novel prognostic factor in nasopharyngeal carcinoma: a meta-analysis. | the plasma epstein-barr virus (ebv) dna level in patients with nasopharyngeal carcinoma (npc) performs as an appealing prognostic factor, but conclusions of its prognostic values from previous studies are inconsistent. in this study, we performed a comprehensive meta-analysis to evaluate the prognostic value of ebv dna level in patients with npc. | 2016 | 27749596 |
| clinicopathological features of 11 epstein-barr virus-associated intrahepatic cholangiocarcinoma at a single center in china. | to date, only 20 cases of epstein-barr virus (ebv)-associated intrahepatic cholangiocarcinomas (ihccs) have been reported in the literature.pathology records of ihcc from january 1, 2007 to december 31, 2013 were retrieved from our hospital. clinical information related to ebv-associated ihcc were also obtained, including gender, age at initial diagnosis, tumor size, tumor-node-metastasis stage, and follow-up duration. surgically resected stage-matched ebv-negative ihccs with full follow-up were ... | 2016 | 27749575 |
| nasopharyngeal carcinoma: understanding its molecular biology at a fine scale. | among all cancers, the incidence of nasopharyngeal carcinoma (npc) is quite high in the endemic regions. npc is a head and neck cancer with poor survival rate, and is rare throughout most of the world but common in certain geographic areas, like southern asia and some regions of north east india (nagaland, manipur, and mizoram). a clear understanding of its etiology is still lacking, but npc is widely suspected to be the result of both genetic susceptibility and exposure to environmental factors ... | 2016 | 27748661 |
| severe epstein-barr virus infection in primary immunodeficiency and the normal host. | epstein-barr virus (ebv) infection is ubiquitous in humans, but the majority of infections have an asymptomatic or self-limiting clinical course. rarely, individuals may develop a pathological ebv infection with a variety of life threatening complications (including haemophagocytosis and malignancy) and others develop asymptomatic chronic ebv viraemia. although an impaired ability to control ebv infection has long been recognised as a hallmark of severe t-cell immunodeficiency, the advent of nex ... | 2016 | 27748521 |
| ubiquitous distribution of epstein-barr virus and the highly uneven distribution of nasopharyngeal carcinoma. | 2016 | 27748347 | |
| the promise of pd-1 inhibitors in gastro-esophageal cancers: microsatellite instability vs. pd-l1. | preliminary clinical studies of anti-programmed cell death-1 (anti-pd-1) therapy in gastro-esophageal cancers have suggested promising single-agent activity. in patients who received prior treatment for advanced disease, pembrolizumab has been associated with a response rate of 20% in programmed cell death-1 ligand 1 (pd-l1)-positive tumors, and nivolumab with a response rate of 12% in unselected tumors. both agents yielded a median duration of response lasting ~6-7 months. pd-l1 expression and ... | 2016 | 27747091 |
| post-transplant lymphoproliferative disorder presenting as cd20-negative plasmablastic lymphoma in the lung. | post-transplant lymphoproliferative disorders (ptld) are a serious complication of transplantation with a high mortality. most ptld present within the first year of transplantation and are associated with epstein-barr virus (ebv) infection. plasmablastic lymphoma (pbl) is a rare but aggressive disease originally described in patients with hiv, presenting most commonly in the jaw and oral mucosa. to our knowledge, this is the first case of pbl presenting as ptld of the lung in a hiv and ebv negat ... | 2016 | 27746876 |
| meta-analysis of the prognostic and clinical value of tumor-associated macrophages in adult classical hodgkin lymphoma. | the prognostic significance of tumor-associated macrophages (tam) in adult classical hodgkin lymphoma (chl) remains controversial. here, we report a meta-analysis of the association of cd68 and cd163 infiltration on the clinical outcome of adult chl. | 2016 | 27745550 |
| kidney graft leiomyosarcoma: a case report. | kidney transplant (kt) recipients have a higher incidence of malignancy than the general population. smooth muscle tumors (smt), including leiomyosarcoma, are rare in kidney transplant recipients, and most cases are associated with epstein-barr virus (ebv) infection. | 2016 | 27742302 |
| transgenic mouse models of tumor virus action. | genetically engineered mice (gems) have provided valuable insights into the carcinogenic properties of various human tumor viruses, which, in aggregate, are etiologically associated with over 15% of all human cancers. this review provides an overview of seminal discoveries made through the use of gem models for human dna tumor viruses. emphasis is placed on the discoveries made in the study of human papillomaviruses, merkel cell carcinoma-associated polyomavirus, epstein-barr virus, and kaposi's ... | 2016 | 27741405 |
| pd-l1 is upregulated by ebv-driven lmp1 through nf-κb pathway and correlates with poor prognosis in natural killer/t-cell lymphoma. | natural killer/t-cell lymphoma (nktcl) is an epstein-barr virus (ebv)-associated, highly aggressive lymphoma. treatment outcome remains sub-optimal, especially for advanced-stage or relapsed diseases. programmed cell death receptor 1 (pd-1) and pd ligand 1 (pd-l1) have become promising therapeutic targets for various malignancies, but their role in the pathogenesis and their interactions with ebv in nktcl remains to be investigated. | 2016 | 27737703 |
| grey zone lymphoma with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma: a clinicopathological study of 14 epstein-barr virus-positive cases. | to investigate the clinicopathological features of epstein-barr virus (ebv)-positive grey zone lymphoma (gzl) with features intermediate between diffuse large b-cell lymphoma (dlbcl) and classical hodgkin lymphoma (chl). | 2017 | 27735994 |
| fatal outcome of an epstein-barr virus positive mucocutaneous ulcer secondary to methotrexate. | 2016 | 27734625 | |
| the immunobiology of interleukin-35 and its regulation and gene expression. | interleukin-35 (il-35) is the latest addition to the il-12 family of heterodimeric cytokines, consisting of il-12 p35 subunit and il-27β subunit epstein-barr virus induced 3 (ebi3). since its discovery, il-35 has been shown to exhibit immunosuppressive activities which are distinct from other members of il-12 family. il-35 is also unique in that it is expressed primarily by regulatory t-cells (tregs) rather than by antigen-presenting cells (apcs). il-35 can directly suppress effector t-cell prol ... | 2016 | 27734415 |
| distinct expression profile of key molecules in crawling-type early gastric carcinoma. | gastric "crawling-type" adenocarcinoma (cra) is a tumor histologically characterized by irregularly fused glands with low-grade cellular atypia that tends to spread laterally in the mucosa. to date, the expression characteristics of the key molecules involved in cra, including receptor tyrosine kinases (rtks), mismatch repair (mmr) proteins, phosphatase and tensin homolog (pten), as well as the epstein-barr virus (ebv) status, have yet to be uncovered. | 2016 | 27734272 |
| high epstein-barr virus load and genomic diversity are associated with generation of gp350-specific neutralizing antibodies following acute infectious mononucleosis. | the epstein-barr virus (ebv) gp350 glycoprotein interacts with the cellular receptor to mediate viral entry and is thought to be the major target for neutralizing antibodies. to better understand the role of ebv-specific antibodies in the control of viral replication and the evolution of sequence diversity, we measured ebv gp350-specific antibody responses and sequenced the gp350 gene in samples obtained from individuals experiencing primary ebv infection (acute infectious mononucleosis [aim]) a ... | 2017 | 27733645 |
| cellular models for mitochondrial dna-based diseases: lymphoblastoid cell lines and transmitochondrial cybrids. | mitochondrial dna (mtdna) mutations cause a variety of mitochondrial dna-based diseases which have been studied using lymphoblastoid cell lines (lcls) and transmitochondrial cybrids. individual genetic information is preserved permanently in lcls while the development of transmitochondrial cybrids provide ex-vivo cellular platform to study molecular mechanism of mitochondrial dna-based diseases. the cytoplasmic donor cells for previous transmitochondrial cybrids come from patient's tissue or pla ... | 2016 | 27733340 |
| tofacitinib induces g1 cell-cycle arrest and inhibits tumor growth in epstein-barr virus-associated t and natural killer cell lymphoma cells. | epstein-barr virus (ebv) infects not only b cells, but also t cells and natural killer (nk) cells, and is associated with t or nk cell lymphoma. these lymphoid malignancies are refractory to conventional chemotherapy. we examined the activation of the jak3/stat5 pathway in ebv-positive and -negative b, t and nk cell lines and in cell samples from patients with ebv-associated t cell lymphoma. we then evaluated the antitumor effects of the selective jak3 inhibitor, tofacitinib, against these cell ... | 2016 | 27732937 |
| mutational analysis of extranodal nk/t-cell lymphoma using targeted sequencing with a comprehensive cancer panel. | extranodal natural killer (nk)/t-cell lymphoma, nasal type (nktcl), is a malignant disorder of cytotoxic lymphocytes of nk or t cells. it is an aggressive neoplasm with a very poor prognosis. although extranodal nktcl reportedly has a strong association with epstein-barr virus, the molecular pathogenesis of nktcl has been unexplored. the recent technological advancements in next-generation sequencing (ngs) have made dna sequencing cost- and time-effective, with more reliable results. using the i ... | 2016 | 27729836 |
| the increased antibody response to epstein-barr virus in multiple sclerosis is restricted to selected virus proteins. | multiple sclerosis (ms) is associated with epstein-barr virus (ebv) infection, and the antibody response to ebv is reported to be increased in ms. ebv contains multiple antigens, and only a few have been investigated. our hypothesis is that ms patients will have an increased antibody response to only selected ebv antigens. we used immunoprecipitation and quantitative mass spectrometry to identify candidate ebv antigens. we then measured the antibody response to 10 individual ebv proteins with qu ... | 2016 | 27725113 |
| no definite clinical features of immunoglobulin g4-related disease in patients with pulmonary nodular lymphoid hyperplasia. | pulmonary nodular lymphoid hyperplasia (pnlh) may show heavy lymphoplasmacytic infiltrates with increased immunoglobulin g4 (igg4)-positive plasma cells as in igg4-related disease (igg4-rd). however, it is unclear whether pnlh could be a manifestation of igg4-rd. a recent study reported the presence of epstein-barr virus (ebv) in igg4-related lymphadenopathy. we postulated that a subset of pnlh might represent igg4-related lung disease with ebv-positive lymphocytes as has been reported in igg4-r ... | 2017 | 27720730 |
| concordance of immune checkpoints within tumor immune contexture and their prognostic significance in gastric cancer. | checkpoint blockade therapy has emerged as a novel approach for cancer immunotherapy in several malignancies. however, patient prognosis and disease progression relevant to immune checkpoints in gastric tumor microenvironment are not defined. this study aims to investigate the expression and prognostic significance of immune checkpoints within gastric cancer. in the study, a cohort of 398 cancer tissues from stage i to iv gastric cancer patients were assessed for programmed cell death 1 ligand 1 ... | 2016 | 27720576 |
| [clinical features and outcomes: analysis of 9 cases of hiv-negtive plasmablastic lymphoma]. | objective: to evaluate the clinical features and outcomes of hiv-negtive plasmablastic lymphoma (pbl). methods: nine patients with hiv-negtive pbl were diagnosed and treated between january 2006 and january 2016. the clinical and follow-up data were analyzed retrospectively. results: the median age was 56 years (range 30-77 years) with a male-to-female ratio of 2∶1. nobody had underlying diseases associated with immunosuppression. primary extra nodal diseases were observed in 7 cases and only 1 ... | 2016 | 27719718 |
| the epstein-barr virus dna load in the peripheral blood of transplant recipients does not accurately reflect the burden of infected cells. | transplant recipients frequently exhibit an increased epstein-barr virus (ebv) load in the peripheral blood. here, we quantitated the ebv-infected cells in the peripheral blood of these patients and defined the mode of viral infection, latent or lytic. these data indicated that there is no strong correlation between the number of infected cells and the ebv load (ebvl). this can be explained by a highly variable number of ebv copies per infected cell and by lytic replication in some cells. the pl ... | 2017 | 27717030 |
| [infectious diseases after lung transplantation]. | lung transplantation is getting to be a common treatment for the end-stage respiratory failure. therefore we might encounter the various issues associated with infection under immunosuppression. at 1st, virus infections occur by cytomegalovirus, epstein-barr virus, hepatitis b and c virus and john cunningham virus. the 2nd, bacterial infections exacerbate graft condition by methicillin-resistant staphylococcus aureus, pseudomonas, burkholderia cepacia and coagulase negative staphylococci. the 3r ... | 2016 | 27713192 |
| diagnostic dilemma: epstein-barr virus (ebv) infectious mononucleosis with lung involvement or co-infection with legionnaire's disease? | hospitalized adults with fever and "pneumonia" can be a difficult diagnostic challenge particularly when the clinical findings may be due to different infectious diseases. | 2016 | 27712834 |
| transmission of viral disease to the recipient through the donor liver. | morbidity and mortality after liver transplantation continue to be significantly influenced by infectious complications. a particular concern is transmission of pathogens through the graft, which may cause significant disease in the recipient. | 2007 | 27711010 |
| circulating epstein-barr virus-encoded micro-rnas as potential biomarkers for nasal natural killer/t-cell lymphoma. | nasal natural killer/t-cell lymphoma (nnktl) is an epstein-barr virus (ebv)-associated malignancy and is characterized by local invasion and widespread dissemination, with a consequent poor prognosis. micro-rnas (mirnas) play roles in the pathogenesis of several malignancies by regulating gene expression and have been recently identified as stable entities in serum. here, we investigated the value of circulating ebv-mirnas as biomarkers for nnktl. sera of patients with nnktl were subjected to mi ... | 2016 | 27709652 |
| mutagenesis and genome engineering of epstein-barr virus in cultured human cells by crispr/cas9. | the clustered regularly interspaced short palindromic repeats (crispr)-crispr associated protein 9 nuclease (cas9) system is a powerful genome-editing tool for both chromosomal and extrachromosomal dna. dna viruses such as epstein-barr virus (ebv), which undergoes episomal replication in human cells, can be effectively edited by crispr/cas9. we have demonstrated targeted editing of the ebv genome by crispr/cas9 in several lines of ebv-infected cells. crispr/cas9-based mutagenesis and genome engi ... | 2017 | 27709566 |
| erk/c-jun recruits tet1 to induce zta expression and epstein-barr virus reactivation through dna demethylation. | dna demethylation plays an essential role in the reactivation of epstein-barr virus (ebv) from latency infection. however, it is unclear how epigenetic modification is initiated in responding to stimuli. here, we demonstrate that erk/c-jun signaling is involved in dna demethylation of ebv immediate early (ie) gene zta in response to 12-o-tetradecanoylphorbol-13-acetate (tpa) stimulation. remarkably, ser73 phosphorylation of c-jun facilitates zta promoter demethylation and ebv reactivation, where ... | 2016 | 27708396 |
| the efficacy of valganciclovir for prevention of infections with cytomegalovirus and epstein-barr virus after kidney transplant in children. | this study evaluated the efficacy of prophylactic valgcv in preventing cmv and ebv infections in a single-center pediatric kidney transplant population (2008-2014). therapy duration was determined according to donor/recipient serostatus. ebv monitoring was performed using monthly plasma pcr for 18 months post-transplant and for cmv, monthly for 6 months after prophylaxis cessation. data were collected on 35 children, median age 10.6 years. there were 15 (42.9%) and 11 (31.4%) recipients seronega ... | 2017 | 27704725 |
| expression of epstein-barr virus among oral potentially malignant disorders and oral squamous cell carcinomas in the south indian tobacco-chewing population. | oral cancer is the sixth most common malignancy in the world. viruses are the causative agents of approximately 10-15% of all cancers worldwide (cancers, 6, 2014 and 2155). the tumorigenic roles of epstein-barr virus in oral cancer are unclear. literature search results are conflicting and dependent on various factors such as geographical/regional variations, sociocultural lifestyles, dietary habits, chewing/smoking tobacco habit. this study is the first original observation about frequency of e ... | 2016 | 27704636 |
| identification of genes involved in epstein-barr virus-associated nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is the most common cancer originating from the nasopharynx, and can be induced by infection with epstein-barr virus (ebv). to study the mechanisms of ebv-associated npc, a microarray of the gse12452 dataset was analyzed. gse12452 was downloaded from gene expression omnibus and consisted of 31 npc samples and 10 normal healthy nasopharyngeal tissue samples. the differentially-expressed genes (degs) were screened using the linear models for microarray data package in ... | 2016 | 27698802 |
| epstein-barr virus micrornas reduce immune surveillance by virus-specific cd8+ t cells. | infection with epstein-barr virus (ebv) affects most humans worldwide and persists life-long in the presence of robust virus-specific t-cell responses. in both immunocompromised and some immunocompetent people, ebv causes several cancers and lymphoproliferative diseases. ebv transforms b cells in vitro and encodes at least 44 micrornas (mirnas), most of which are expressed in ebv-transformed b cells, but their functions are largely unknown. recently, we showed that ebv mirnas inhibit cd4(+) t-ce ... | 2016 | 27698133 |
| dynamics of epstein-barr viral load after hematopoietic stem cell transplantation and effect of preemptive rituximab therapy. | epstein-barr virus (ebv) displays oncogenic properties, particularly in the immunocompromised host. notably, hematopoietic stem cell transplantation (hsct) recipients with a detectable blood ebv viral load (bebvl) are considered at higher risk of post-transplant lymphoproliferative diseases (ptld). therefore, bebvl is monitored after hsct, and preemptive rituximab may be used in patients with high values. however, little is known about post-hsct bebvl dynamics, and the threshold that should lead ... | 2016 | 27696681 |
| plasma epstein-barr virus and hepatitis b virus in non-hodgkin lymphomas: two lymphotropic, potentially oncogenic, latently occurring dna viruses. | there is a need to study potential infective etiologies in lymphomas. lymphocyte-transforming viruses can directly infect lymphocytes, disrupt normal cell functions, and promote cell division. epstein-barr virus (ebv) is known to be associated with several lymphomas, especially hodgkin lymphomas (hls). and recently, the lymphocyte-transforming role of hepatitis b virus (hbv) has been emphasized. | 2017 | 27688607 |
| epstein-barr virus: more than 50 years old and still providing surprises. | it is more than 50 years since the epstein-barr virus (ebv), the first human tumour virus, was discovered. ebv has subsequently been found to be associated with a diverse range of tumours of both lymphoid and epithelial origin. progress in the molecular analysis of ebv has revealed fundamental mechanisms of more general relevance to the oncogenic process. this timeline article highlights key milestones in the 50-year history of ebv and discusses how this virus provides a paradigm for exploiting ... | 2016 | 27687982 |
| second malignant neoplasm following childhood cancer: a nested case-control study of a recent cohort (1987-2004) from the childhood cancer registry of the rhône-alpes region in france. | from a population-based cohort of cases of first cancers diagnosed between 1987 and 2004, before the patient's age of 15 years, the authors conducted a nested case-control study, matching 64 patients who experienced a second malignant neoplasm (smn) with 190 controls. smns comprised 10 leukemia or myelodysplastic syndromes, 5 lymphomas induced by epstein-barr virus after allograft, and 49 solid tumors, including mainly 25 carcinomas (17 of the thyroid), 9 bone sarcomas, and 7 central nervous sys ... | 2016 | 27687523 |
| ganetespib, an hsp90 inhibitor, kills epstein-barr virus (ebv)-infected b and t cells and reduces the percentage of ebv-infected cells in the blood. | hsp90 inhibitors have been shown to kill epstein-barr virus (ebv)-infected cells by reducing the level of ebv ebna-1 and/or lmp1. we treated virus-infected cells with ganetespib, an hsp90 inhibitor currently being evaluated in multiple clinical trials for cancer and found that the drug killed ebv-positive b and t cells and reduced the level of both ebv ebna-1 and lmp1. treatment of cells with ganetespib also reduced the level of pakt. ganetespib delayed the onset of ebv-positive lymphomas and pr ... | 2017 | 27686857 |
| potential interest in circulating mir-bart17-5p as a post-treatment biomarker for prediction of recurrence in epstein-barr virus-related nasopharyngeal carcinoma. | epstein-barr virus (ebv)-related micornas (mirnas), bamhi-a rightward transcripts (bart)-mirnas, are released in a stable form from viable cells, which are abundant in patients with ebv-positive nasopharyngeal carcinoma (npc). we estimated copy numbers of circulating mir-bart2-5p, mir-bart17-5p, and mir-bart18-5p as well as bamhi-w dna as biomarkers. | 2017 | 27684719 |
| recent insights in the pathogenesis of post-transplantation lymphoproliferative disorders. | post-transplant lymphoproliferative disorder (ptld) is an aggressive complication of solid organ and hematopoietic stem cell transplantation that arises in up to 20% of transplant recipients. infection or reactivation of the epstein-barr virus (ebv), a ubiquitous human herpesvirus, in combination with chronic immunosuppression are considered as the main predisposing factors, however insight in ptld biology is fragmentary. the study of ptld is complicated by its morphological heterogeneity and th ... | 2016 | 27683629 |
| idiopathic nephrotic syndrome: the ebv hypothesis. | steroid sensitive nephrotic syndrome is marked by a massive proteinuria and loss of podocytes foot processes. the mechanism of the disease remains debated but recent publications suggest a primary role of epstein-barr virus (ebv). ebv replication in the peripheral blood is found in 50% of patients during the first flare of the disease. the genetic locus of steroid sensitive nephrotic syndrome was also identified as influencing antibodies directed against ebna1. ebv is able to establish, latent b ... | 2017 | 27682967 |
| elevated level of interleukin-35 in colorectal cancer induces conversion of t cells into itr35 by activating stat1/stat3. | il-35 is a novel heterodimeric and inhibitory cytokine, composed of interleukin-12 subunit alpha (p35) and epstein-barr virus -induced gene 3 (ebi3). il-35 has been reported to be produced by a range of cell types, especially regulatory t cells, and to exert immunosuppressive effects via the statx signaling pathway. in this study, we demonstrated that il-35 expression was elevated in both serum and tumors in patients with colorectal cancer. il-35 mainly expressed in cd4+ t cells in human colorec ... | 2016 | 27682874 |
| clinical outcome and morbidity in pediatric patients with nasopharyngeal cancer treated with chemoradiotherapy. | the aim of the study was to evaluate the outcome and treatment-related morbidity in pediatric patients with nasopharyngeal carcinoma (npc) treated with chemoradiotherapy. | 2017 | 27681956 |
| anti-cancer effect of quercetin in xenograft models with ebv-associated human gastric carcinoma. | licorice extracts have been widely used in herbal and folk medications. glycyrrhiza contains diverse range of biological compounds including triterpenes (glycyrrhizin, glycyrrhizic acid) and flavonoids (quercetin, liquiritin, liquiritigenin, glabridin, licoricidin, isoliquiritigenin). the flavonoids in licorice are known to have strong anti-cancer activities. quercetin, the most abundant flavonoid, has been shown to have anti-ulcer, anti-cancer, antioxidant, and anti-inflammatory properties. lat ... | 2016 | 27681719 |
| xiap deficiency and mefv variants resulting in an autoinflammatory lymphoproliferative syndrome. | a 16-year-old boy of caucasian ethnicity was evaluated for recurrent febrile episodes occurring during most of his life without establishment of any microbial aetiology. during febrile episodes he developed extensive splenomegaly, lymphadenopathy, anaemia, severe abdominal pain and general malaise. lymph node biopsies demonstrated inflammation and sinus histiocytosis but no malignancy or granuloma. the patient underwent seroconversion for epstein-barr virus (ebv) infection during the hospitalisa ... | 2016 | 27681353 |
| denis burkitt: a legacy of global health. | when first described in 1958, burkitt lymphoma was considered by many to be an african curiosity. however, over the next few decades, over 10,000 publications on burkitt lymphoma would influence many facets of oncology research including immunology, molecular genetics, chemotherapy, and viral oncology. at the time of discovery, its distribution in equatorial africa was unique; it was where a child was born and lived, and not what race they were, that conveyed the greatest incidence risk. its ass ... | 2016 | 27681061 |
| extranodal natural killer/t-cell lymphoma, nasal type, with primary manifestation as an upper eyelid swelling. | extranodal natural killer/t-cell lymphoma (enk/tcl) is most often in the nose or the nasopharynx but can present elsewhere. we report a rare case of enk/tcl that presented as swelling of an upper eyelid without ocular involvement. a 76-year-old man visited our hospital with a swollen lesion of the left upper eyelid which had appeared 2 months earlier. a biopsy of the upper eyelid revealed slight perivascular and periadnexal infiltration of mononuclear cells with dermal edema. treatment with oral ... | 2016 | 27680487 |
| epstein-barr virus-associated gastric cancer and potential mechanisms of oncogenesis. | ebv-associated gastric cancer (ebvagc) comprises about 9% of all cases of gc and constitutes a distinct clinicopathological and molecular entity. the pattern of viral expression in ebvagc cannot be set to any of the previously ebv-associated malignancies. several lines of evidence support that viral expression in ebvagc is characterized by high transcription of the bamh1-a rightward transcript (bart), low-levels of ebna-1 and lack of lmp1. the high transcription activity of the bamh1-a region is ... | 2016 | 27677953 |
| [mr-imaging findings in epstein-barr virus encephalitis]. | 2016 | 27677103 | |
| lymphomatoid granulomatosis associated with azathioprine use for immune-mediated neuropathy. | lymphomatoid granulomatosis (lg) is a rare epstein-barr virus-driven lymphoproliferative disorder that generally arises in immunosuppressed patients and which can be life-threatening. here we describe the development of pulmonary lg in a patient on long-term azathioprine for immune-mediated neuropathy. although azathioprine carries a boxed warning for malignancy, its association specifically with lg, an otherwise rare entity, is poorly recognised. early recognition of drug-induced lg is critical ... | 2016 | 27671987 |
| serum b-cell activating factor predicts prognosis in nasal type, extranodal nk/t cell lymphoma. | b-cell activating factor (baff) plays important roles in a variety of lymphoid malignancies. compared with healthy adults, patients with non-hodgkin lymphoma had higher level of serum baff, and it corresponded with disease severity, response for therapy and clinical outcome. latent membrane protein 1 (lmp1) encoded by epstein-barr virus (ebv) which is a known agent of nasal, extranodal nk/t cell lymphoma (enktcl) can switch the baff activating promoter leading to higher expression of baff in ebv ... | 2016 | 27668971 |
| a prospective study of alemtuzumab as a second-line agent for steroid-refractory acute graft-versus-host disease in pediatric and young adult allogeneic hematopoietic stem cell transplantation. | we describe a single-center prospective study of alemtuzumab as a second-line agent for steroid-refractory (sr) acute graft-versus-host disease (agvhd) in pediatric and young adult allogeneic hematopoietic stem cell transplant recipients. alemtuzumab was administered for grades ii to iv agvhd if patients did not improve within 5 days or worsened within 48 hours after corticosteroids. interim analyses of alemtuzumab levels and response were performed after every 5 patients enrolled, resulting in ... | 2016 | 27664325 |
| negative interaction between smoking and ebv in the risk of multiple sclerosis: the envims study. | results from previous studies on a possible interaction between smoking and epstein-barr virus (ebv) in the risk of multiple sclerosis (ms) are conflicting. | 2016 | 27663872 |
| fluoro analogs of bioactive oxy-sterols: synthesis of an ebi2 agonist with enhanced metabolic stability. | synthesis of several 7-hydroxy oxysterols and their potential roles as signaling molecules in the innate and adaptive immune responses is discussed. discovery of a new, fluorinated, synthetic analog of the 7α,25-dihydroxycholesterol-the endogenous ligand of gpr 183 (ebi2), a g-protein coupled receptor highly expressed upon epstein-barr virus infection is described. fluoro oxysterol 12 showed good metabolic stability while maintaining excellent ebi2 agonist activity. | 2016 | 27658369 |
| expression and methylation data from sle patient and healthy control blood samples subdivided with respect to arid3a levels. | previously published studies revealed that variation in expression of the dna-binding protein arid3a in b lymphocytes from patients with systemic lupus erythematosus (sle) correlated with levels of disease activity ("disease activity in systemic lupus erythematosus correlates with expression of the transcription factor at-rich-interactive domain 3a" (j.m. ward, k. rose, c. montgomery, i. adrianto, j.a. james, j.t. merrill et al., 2014) [1]). the data presented here compare dna methylation patter ... | 2016 | 27656675 |
| epstein-barr virus exploits host endocytic machinery for cell-to-cell viral transmission rather than a virological synapse. | epstein-barr virus (ebv) establishes a lifelong latent infection in b lymphocytes and often is found in epithelial cells. several lines of evidence indicate that viral transmission mediated by cell-to-cell contact is the dominant mode of infection by ebv for epithelial cells. however, its detailed molecular mechanism has not been fully elucidated. we investigated the role of host membrane trafficking machinery in this process. we have found that adhesion molecules critical for this process are e ... | 2016 | 27655016 |
| phage-display screening identifies lmp1-binding peptides targeting the c-terminus region of the ebv oncoprotein. | latent membrane protein 1 (lmp1), a major oncoprotein of epstein barr virus (ebv) is responsible for transforming b lymphocytes in vitro. lmp1 is overexpressed in several ebv-associated malignancies, and different approaches have been developed to reduce its level and accordingly its oncogenic function in tumor tissues. this study aimed to use phage display peptide library to obtain peptides which could specifically bind to the cytoplasmic region of lmp1 to prevent its interaction with signaling ... | 2016 | 27650372 |
| viral il-10 down-regulates the "mhc-i antigen processing operon" through the nf-κb signaling pathway in nasopharyngeal carcinoma cells. | the hla-i antigen processing machinery (apm) plays a crucial role in the anticancer immune response. the loss of surface expression of hla-i molecules is particularly important as this enables tumor cells to evade recognition and lysis by cytotoxic t-lymphocytes. transcriptional control of the apm genes is regulated by the nuclear factor kappa b (nf-κb). bcrfl is an epstein-barr virus homologue of human il-10 (hil-10) and is known as viral il-10 (vil-10). vil-10 shares many immunosuppressive eff ... | 2016 | 27650182 |
| primary cardiac diffuse large b-cell lymphoma in immunocompetent patients: clinical, histologic, immunophenotypic, and genotypic features of 3 cases. | primary cardiac lymphoma (pcl) is a rare extranodal lymphoma that involves only the heart and/or pericardium. primary cardiac lymphoma is much less common in immunocompetent patients compared with those who are immunosuppressed. patients with pcl have variable clinical manifestations that may lead to misdiagnosis and delay in treatment. modern radiologic imaging now allows for earlier detection of these tumors. this study describes the clinical, histologic/cytologic, immunophenotypic, and molecu ... | 2016 | 27649953 |
| infection-related death among persons with refractory juvenile idiopathic arthritis. | severe infections are emerging as major risk factors for death among children with juvenile idiopathic arthritis (jia). in particular, children with refractory jia treated with long-term, multiple, and often combined immunosuppressive and antiinflammatory agents, including the new biological disease-modifying antirheumatic drugs (dmards), are at increased risk for severe infections and death. we investigated 4 persons with jia who died during 1994-2013, three of overwhelming central venous cathe ... | 2016 | 27648582 |
| inflammation-related dna damage and cancer stem cell markers in nasopharyngeal carcinoma. | nitrative and oxidative dna damage plays an important role in inflammation-related carcinogenesis. to investigate the involvement of stem cells in epstein-barr virus infection-related nasopharyngeal carcinoma (npc), we used double immunofluorescence staining to examine several cancer stem/progenitor cell markers (cd44v6, cd24, and aldh1a1) in npc tissues and npc cell lines. we also measured 8-nitroguanine formation as an indicator of inflammation-related dna lesions. the staining intensity of 8- ... | 2016 | 27647953 |
| acute west nile virus meningoencephalitis diagnosed via metagenomic deep sequencing of cerebrospinal fluid in a renal transplant patient. | solid organ transplant patients are vulnerable to suffering neurologic complications from a wide array of viral infections and can be sentinels in the population who are first to get serious complications from emerging infections like the recent waves of arboviruses, including west nile virus, chikungunya virus, zika virus, and dengue virus. the diverse and rapidly changing landscape of possible causes of viral encephalitis poses great challenges for traditional candidate-based infectious diseas ... | 2017 | 27647685 |
| [clinicopathologic features of non-keratinizing carcinoma of nasal cavity and paranasal sinus]. | to study the clinicopathologic features, immunophenotype, differential diagnosis and prognosis of non-keratinizing carcinoma of nasal cavity and paranasal sinus. | 2016 | 27646894 |
| lack of heterologous cross-reactivity toward hla-a*02:01 restricted viral epitopes is underpinned by distinct αβt cell receptor signatures. | αβt cell receptor (tcr) genetic diversity is outnumbered by the quantity of pathogenic epitopes to be recognized. to provide efficient protective anti-viral immunity, a single tcr ideally needs to cross-react with a multitude of pathogenic epitopes. however, the frequency, extent, and mechanisms of tcr cross-reactivity remain unclear, with conflicting results on anti-viral t cell cross-reactivity observed in humans. namely, both the presence and lack of t cell cross-reactivity have been reported ... | 2016 | 27645996 |
| cd20 therapies in multiple sclerosis and experimental autoimmune encephalomyelitis - targeting t or b cells? | ms is widely considered to be a t cell-mediated disease although t cell immunotherapy has consistently failed, demonstrating distinct differences with experimental autoimmune encephalomyelitis (eae), an animal model of ms in which t cell therapies are effective. accumulating evidence has highlighted that b cells also play key role in ms pathogenesis. the high frequency of oligoclonal antibodies in the csf, the localization of immunoglobulin in brain lesions and pathogenicity of antibodies origin ... | 2016 | 27645355 |
| neutrophil-to-lymphocyte ratio as a prognostic marker in locally advanced nasopharyngeal carcinoma: a pooled analysis of two randomised controlled trials. | to assess the prognostic value of neutrophil-to-lymphocyte ratio (nlr) in patients with international union against cancer (uicc)-staged iii/iva,b nasopharyngeal carcinoma (npc), who were enrolled into two randomised controlled trials of concurrent/adjuvant chemotherapy when added to radiotherapy (sqnp01), and induction chemotherapy when added to chemoradiotherapy (ncc0901). | 2016 | 27640138 |
| retrospective analysis of oncogenic human papilloma virus and epstein-barr virus prevalence in turkish nasopharyngeal cancer patients. | nasopharyngeal carcinoma (npc) is associated with the epstein-barr virus (ebv). human papilloma virus (hpv) has also been detected in npc cases. in this retrospective study, we analyze the frequency of ebv and hpv infection in 82 turkish patients with npc. a total of 82 were evaluated for ebv and hpv. in situ hybridization (ish) was performed for ebv. hpv-ish and p16 immunohistochemistry used to determine the hpv status. seventy-two of the 82 (87%) npc patients were ebv-positive. the highest rat ... | 2016 | 27640103 |
| large retropharyngeal abscess: a case of mistaken identity. | we report an unusual case of nasopharyngeal carcinoma (npc), presenting initially as a retropharyngeal collection. we discuss the investigation, diagnosis and management of npc and furthermore review the literature of npc, emphasising the varied presentation. a 44-year-old caucasian male ex-smoker presented with a 10-day history of a painless left-sided neck lump; progressive dysphagia and unintentional weight loss. examination demonstrated a large left posterior pharyngeal swelling with soft pa ... | 2016 | 27637277 |
| geographic population structure in epstein-barr virus revealed by comparative genomics. | epstein-barr virus (ebv) latently infects the majority of the human population and is implicated as a causal or contributory factor in numerous diseases. we sequenced 27 complete ebv genomes from a cohort of multiple sclerosis (ms) patients and healthy controls from italy, although no variants showed a statistically significant association with ms. taking advantage of the availability of ∼130 ebv genomes with known geographical origins, we reveal a striking geographic distribution of ebv sub-pop ... | 2016 | 27635051 |
| epstein-barr virus latent membrane protein-1 up-regulates cytokines and correlates with older age and poorer prognosis in hodgkin lymphoma. | previously, we reported an association between epstein-barr virus (ebv)-positive hodgkin lymphoma (hl), older age, and poorer prognosis. the aim of this study was to investigate the mechanisms underlying this association. | 2017 | 27632954 |
| pretransplant prophylactic rituximab to prevent epstein-barr virus (ebv) viremia in ebv-seronegative kidney transplant recipients from ebv-seropositive donors: results of a pilot study. | because of the strikingly increased risk of post-transplant lymphoproliferative disorder (ptld) in epstein-barr virus (ebv)-seronegative kidney transplant recipients (ktrs) from ebv-seropositive donors-ebv(d(+) r(-) ), special strategies need to be defined to prevent ebv transmission and ebv viremia. | 2016 | 27632022 |
| ebv-negative aggressive nk-cell leukemia/lymphoma: clinical, pathologic, and genetic features. | aggressive natural killer cell leukemia (ankl) is a systemic nk-cell neoplasm, almost always associated with epstein-barr virus (ebv). rare cases of ebv-negative ankl have been described, and some reports suggested more indolent behavior. we report the clinicopathologic, immunophenotypic, and molecular characteristics of 7 ebv-negative ankl. all patients were adults, with a median age of 63 years (range 22 to 83 y) and an m:f ratio of 2.5:1. five patients were white, 1 black, and 1 asian. all pa ... | 2017 | 27631517 |
| associations between ebv and cmv seropositivity, early exposures, and gut microbiota in a prospective birth cohort: a 10-year follow-up. | early-life infections with persistent epstein-barr virus (ebv) and cytomegalovirus (cmv) are delayed in affluent countries, probably due to alterations in early environmental exposures, such as maternal age, siblings, and day-care attendance. we have previously reported that the timing of ebv and cmv contraction is related both to allergic sensitization and changes in functional competence of immune cells, while the presence/absence of lactobacilli [lactobacillus (l.) casei, l. paracasei, and l. ... | 2016 | 27630978 |
| herpes simplex virus 1 ul37 protein tyrosine residues conserved among all alphaherpesviruses are required for interactions with glycoprotein k, cytoplasmic virion envelopment, and infectious virus production. | the herpes simplex virus 1 (hsv-1) ul37 protein functions in virion envelopment at trans-golgi membranes, as well as in retrograde and anterograde transport of virion capsids. recently, we reported that ul37 interacts with glycoprotein k (gk) and its interacting partner protein ul20 (n. jambunathan, d. chouljenko, p. desai, a. s. charles, r. subramanian, v. n. chouljenko, and k. g. kousoulas, j virol 88:5927-5935, 2014, http://dx.doi.org/10.1128/jvi.00278-14), facilitating cytoplasmic virion env ... | 2016 | 27630233 |
| clinicopathological features of programmed death ligand 1 expression with tumor-infiltrating lymphocyte, mismatch repair, and epstein-barr virus status in a large cohort of gastric cancer patients. | antibodies against programmed death 1 (pd-1) and its ligand programmed death ligand 1 (pd-l1) have recently demonstrated promising results in gastric cancer (gc). pd-l1 expression, the presence of tumor-infiltrating lymphocytes (tils), and mismatch repair (mmr) deficiency have been proposed as predictive biomarkers for anti-pd-1/pd-l1 antibodies. the aim of this study was to investigate the clinical relevance of pd-l1 expression with til, mmr, and epstein-barr virus (ebv) status in gc. | 2016 | 27629881 |
| programmed death-ligand 1 is upregulated in intrahepatic lymphoepithelioma-like cholangiocarcinoma. | intrahepatic lymphoepithelioma-like cholangiocarcinoma (lelcc) is a rare variant of cholangiocarcinoma. here, we report the largest single series of lelcc cases yet studied (n = 13). we retrospectively analyzed the clinical data of the 13 patients and measured the expression of programmed death-ligand 1 (pd-l1) in tumors using immunohistochemical staining. we also analyzed 15 cases of conventional intrahepatic cholangiocarcinoma (ihcc) for comparison. we found that eight patients with lelcc were ... | 2016 | 27626174 |
| methotrexate-induced cd30(+) t-cell lymphoproliferative disorder of the oral cavity. | 2016 | 27626055 | |
| analysis of epstein-barr virus and cellular gene expression during the early phases of epstein-barr virus lytic induction. | in order to develop novel host/pathogen real-time pcr assays for routine diagnostic use, early gene expression patterns from both epstein-barr virus (ebv) and raji cells were examined after inducing the lytic life cycle using 12-o-tetradecanoyl-13-phorbol ester and sodium butyrate. real-time pcr identified several highly induced (>90-fold) ebv lytic genes over a 48 h time course during the lytic induction phase. latent genes were induced at low levels during this phase. the cellular response to ... | 2016 | 27625030 |
| manipulation of the host cell membrane by human γ-herpesviruses ebv and kshv for pathogenesis. | the cell membrane regulates many physiological processes including cellular communication, homing and metabolism. it is therefore not surprising that the composition of the host cell membrane is manipulated by intracellular pathogens. among these, the human oncogenic herpesviruses epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) exploit the host cell membrane to avoid immune surveillance and promote viral replication. accumulating evidence has shown that both ebv and k ... | 2016 | 27624182 |
| shedding of hsv-1, hsv-2, cmv, and ebv in the saliva of hematopoietic stem cell transplant recipients at fundación homi - hospital de la misericordia, bogotá, d.c. | hematopoietic stem cell transplantation in pediatric patients is an alternative treatment for different diseases. the conditioning regimen for transplant predisposes recipients to the development of infections. viral infections by herpes simplex virus 1 (hsv-1), herpes simplex virus 2 (hsv-2), human cytomegalovirus (cmv), and epstein-barr virus (ebv), are the most common, and the leading cause of morbidity and mortality among these patients. these viruses lie dormant in various cell types and th ... | 2016 | 27622810 |
| investigating potential exogenous tumor initiating and promoting factors for cutaneous t-cell lymphomas (ctcl), a rare skin malignancy. | most skin malignancies are caused by external and often preventable environmental agents. multiple reports demonstrated that cutaneous t-cell lymphomas (ctcl) can occur in married couples and cluster in families. furthermore, recent studies document geographic clustering of this malignancy in texas as well as in other areas of the united states. multiple infectious, occupational, and medication causes have been proposed as triggers or promoters of this malignancy including hydrochlorothiazide di ... | 2016 | 27622024 |
| mapping an epitope in ebna-1 that is recognized by monoclonal antibodies to ebna-1 that cross-react with dsdna. | the epstein barr virus (ebv) has been associated with the autoimmune disease, systemic lupus erythematosus (sle). ebv nuclear antigen-i (ebna-1) is the major nuclear protein of ebv. we previously generated an igg monoclonal antibody (mab) to ebna-1, 3d4, and demonstrated that it cross-reacts with double stranded dna (dsdna) and binds the 148 amino acid viral binding site (vbs) in the carboxyl region of ebna-1. the aim of the present study was to characterize another antibody to ebna-1 that cross ... | 2016 | 27621818 |
| nk cell influence on the outcome of primary epstein-barr virus infection. | the herpesvirus epstein-barr virus (ebv) was discovered as the first human candidate tumor virus in burkitt's lymphoma more than 50 years ago. despite its strong growth transforming capacity, more than 90% of the human adult population carries this virus asymptomatically under near perfect immune control. the mode of primary ebv infection is in part responsible for ebv-associated diseases, including hodgkin's lymphoma. it is, therefore, important to understand which circumstances lead to symptom ... | 2016 | 27621731 |