Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| refining the ecological brain: strong relation between the ventromedial prefrontal cortex and feeding ecology in five primate species. | to survive in complex and seasonal environments, primates are thought to rely upon cognitive capacities such as decision-making and episodic memory, which enable them to plan their daily foraging path. according to the ecological brain hypothesis, feeding ecology has driven the expansion of the brain to support the corresponding development of cognitive skills. recent works in cognitive neurosciences indicate that cognitive operations such as decision-making or subjective evaluation (which are c ... | 2019 | 31030897 |
| flavobacterium viscosus sp. nov. and flavobacterium tangerina sp. nov., from primates feces. | strains yim 102796t and yim 102701-2t were isolated from the feces of macaca mulatta and hylobates hoolock, respectively, living in the yunnan wild animal park, yunnan province of china. the two strains were gram-stain-negative, non-gliding, produced flexirubin pigments, non-flagellated and aerobic bacteria. the 16s rrna gene-based phylogenetic analysis indicate that both yim 102796t and yim 102701-2t are members of the genus flavobacterium, closely related to f. ummariense ds-12t (95.9% similar ... | 2019 | 31028411 |
| effects of chronic elevated intraocular pressure on parameters of optical coherence tomography in rhesus monkeys. | to determine the progression of parameters from optical coherence tomography (oct) in chronic elevated intraocular pressure (iop) monkeys. | 2019 | 31024804 |
| aberrant clonal hematopoiesis following lentiviral vector transduction of hspcs in a rhesus macaque. | lentiviral vectors (lvs) are used for delivery of genes into hematopoietic stem and progenitor cells (hspcs) in clinical trials worldwide. lvs, in contrast to retroviral vectors, are not associated with insertion site-associated malignant clonal expansions and, thus, are considered safer. here, however, we present a case of markedly abnormal dysplastic clonal hematopoiesis affecting the erythroid, myeloid, and megakaryocytic lineages in a rhesus macaque transplanted with hspcs that were transduc ... | 2019 | 31023523 |
| the tat inhibitor didehydro-cortistatin a suppresses siv replication and reactivation. | the hiv-1 transactivation protein (tat) binds the hiv mrna transactivation responsive element (tar), regulating transcription and reactivation from latency. drugs against tat are unfortunately not clinically available. we reported that didehydro-cortistatin a (dca) inhibits hiv-1 tat activity. in human cd4+ t cells isolated from aviremic individuals and in the humanized mouse model of latency, combining dca with antiretroviral therapy accelerates hiv-1 suppression and delays viral rebound upon t ... | 2019 | 31021670 |
| regional molecular mapping of primate synapses during normal healthy aging. | normal mammalian brain aging is characterized by the selective loss of discrete populations of dendritic spines and synapses, particularly affecting neuroanatomical regions such as the hippocampus. although previous investigations have quantified this morphologically, the molecular pathways orchestrating preferential synaptic vulnerability remain to be elucidated. using quantitative proteomics and healthy rhesus macaque and human patient brain regional tissues, we have comprehensively profiled t ... | 2019 | 31018120 |
| monochromatic and white light and the regulation of eye growth. | experiments employing monochromatic light have been used to investigate the role of longitudinal chromatic aberration (lca) as possible signals for emmetropization for many years. lca arising from the dispersion of light, causes differences in the focal length at different wavelengths and can impose defocus (wavelength defocus). short-wavelength light focuses with a shorter focal length than long-wavelength light and, as such, would be expected to produce a smaller, more hyperopic eye. emmetropi ... | 2019 | 31018118 |
| influences of demographic, seasonal, and social factors on automated touchscreen computer use by rhesus monkeys (macaca mulatta) in a large naturalistic group. | animals housed in naturalistic social groups with access to automated cognitive testing vary in whether and how much they participate in cognitive testing. understanding how demographic, seasonal, and social factors relate to participation is essential to evaluating the usefulness of these systems for studying cognition and in assessing the data produced. we evaluated how sex, age, reproductive experience, seasonality, and rank related to patterns of participation in a naturalistic group of rhes ... | 2019 | 31017920 |
| formation and decay of auditory short-term memory in the macaque monkey. | echoic memory (em) is a short-lived, precategorical, and passive form of auditory short-term memory (stm). a key hallmark of em is its rapid exponential decay with a time constant between 1 and 2 s. it is not clear whether auditory stm in the rhesus, an important model system, shares this rapid exponential decay. to resolve this shortcoming, two rhesus macaques were trained to perform a delayed frequency discrimination task. discriminability of delayed tones was measured as a function of retenti ... | 2019 | 31017849 |
| safe and sustained expression of human iduronidase after intrathecal administration of adeno-associated virus serotype 9 in infant rhesus monkeys. | many neuropathic diseases cause early, irreversible neurologic deterioration, which warrants therapeutic intervention during the first months of life. in the case of mucopolysaccharidosis type i, a recessive lysosomal storage disorder that results from a deficiency of the lysosomal enzyme α-l-iduronidase (idua), one of the most promising treatment approaches is to restore enzyme expression through gene therapy. specifically, administering pantropic adeno-associated virus (aav) encoding idua into ... | 2019 | 31017018 |
| first molecular characterization of balantioides coli (malmsten, 1857) isolates maintained in vitro culture and from feces of captive animals, rio de janeiro, brazil. | ciliate protozoa of the genus balantioides can parasitize a variety of animals. the morphology of the evolutionary forms of the parasite and the host species affected have long been the only characteristics used to taxonomically identify the species of these protozoa, but these variables are not very precise. to confirm species identity, molecular biology tools are currently used. in this context, this study aimed to analyze protozoan isolates maintained in culture medium and from fecal samples ... | 2017 | 31014580 |
| the accuracy and feasibility of robotic assisted lead implantation in nonhuman primates. | deep brain stimulation (dbs) and stereo-electroencephalography (seeg) electrode implantation are the most important and frequent manipulations in nonhuman primates (nhp) neuromodulation research. however, traditional methods tend to be arduous and inaccurate. | 2019 | 31012530 |
| detection of post-vaccination enhanced dengue virus infection in macaques: an improved model for early assessment of dengue vaccines. | the need for improved dengue vaccines remains since the only licensed vaccine, dengvaxia, shows variable efficacy depending on the infecting dengue virus (denv) type, and increases the risk of hospitalization for severe dengue in children not exposed to denv before vaccination. here, we developed a tetravalent dengue purified and inactivated vaccine (dpiv) candidate and characterized, in rhesus macaques, its immunogenicity and efficacy to control denv infection by analyzing, after challenge, bot ... | 2019 | 31009499 |
| corticosteroids and methotrexate as adjuvants to costimulation blockade in non-human primate renal transplantation. | belatacept, the cd28-b7 costimulation pathway inhibitor, has been approved as a calcineurin inhibitor (cni) alternative in kidney transplantation. although costimulation blockade (cob) allows for cni avoidance, it is associated with increased rates of early rejection, prompting a search for agents to pair with belatacept. methotrexate (mtx) is an antimetabolite that has been found to be complimentary with abatacept, a lower affinity cd28-b7-specific analogue of belatacept, in the treatment of rh ... | 2019 | 31006146 |
| chronic heavy drinking drives distinct transcriptional and epigenetic changes in splenic macrophages. | chronic heavy alcohol drinking (chd) leads to significant organ damage, increased susceptibility to infections, and delayed wound healing. these adverse outcomes are believed to be mediated by alterations in the function of myeloid cells; however, the mechanisms underlying these changes are poorly understood. | 2019 | 31005514 |
| a rhesus monkey with a naturally occurring impairment of disparity vergence. ii. abnormal near response cell activity in the supraoculomotor area. | convergence insufficiency is a very common disorder that can have significant adverse effects on school performance. when reading, children with this disorder often experience diplopia and headaches. we have recently obtained a rhesus monkey with a naturally occurring impairment of vergence eye movements. in the companion paper, we report behavioral testing that shows a pattern of impairments similar to what clinicians observe in human children with convergence insufficiency, including a receded ... | 2019 | 30999322 |
| a rhesus monkey with a naturally occurring impairment of disparity vergence. i. behavioral comparisons to vergence in a normal animal. | human children with disorders affecting vergence eye movements have difficulty during close work, such as reading. patients with convergence insufficiency show a receded near point and an exophoria that is greater at near than at far. neurologic abnormalities may underlie these symptoms, but it is difficult to test this idea directly because there is no animal model for this disorder. in the present case report, we describe behavioral testing in a rhesus monkey with a naturally occurring impairm ... | 2019 | 30999321 |
| nonhuman primate vestibuloocular reflex responses to prosthetic vestibular stimulation are robust to pulse timing errors caused by temporal discretization. | electrical stimulation of vestibular afferent neurons to partially restore semicircular canal sensation of head rotation and the stabilizing reflexes that sensation supports has potential to effectively treat individuals disabled by bilateral vestibular hypofunction. ideally, a vestibular implant system using this approach would be integrated with a cochlear implant, which would provide clinicians with a means to simultaneously treat loss of both vestibular and auditory sensation. despite obviou ... | 2019 | 30995152 |
| susceptibility to siv infection after adenoviral vaccination in a low dose rhesus macaque challenge model. | vaccination with the merck human adenovirus serotype-5 (hadv-5) vectored hiv-1 subtype b gag/pol/nef vaccine was unexpectedly associated with enhanced susceptibility to hiv-1 infection in uncircumcised hadv-5 seropositive men. it has been hypothesized that vaccination may have resulted in activated cd4+ t lymphocytes trafficking to mucosal sites thereby increasing targets for hiv infection. we have previously shown that adv-vector vacci-nation in rhesus macaques resulted in an increase in the fr ... | 2019 | 30993250 |
| chronic alcohol drinking slows brain development in adolescent and young adult nonhuman primates. | the transition from adolescence to adulthood is associated with brain remodeling in the final stages of developmental growth. it is also a period when a large proportion of this age group engages in binge alcohol drinking (occasional consumption of four to five drinks leading to intoxication) and heavy alcohol drinking (binge drinking on ≥5 d in a month). here we report on magnetic resonance imaging of developmental changes in the brain occurring during late adolescence and early adulthood (3.5- ... | 2020 | 30993181 |
| low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates. | mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis-associated (enho) gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases of metabolism. however, adropin's roles in human metabolism are unclear. in silico expression profiling in a nonhuman primate diurnal transcriptome atlas (gse98965) revealed a dynamic and diurnal pattern of enho expression. enho expression is abundant in brain, including ven ... | 2019 | 30988006 |
| dysregulation of sonic hedgehog pathway and pericytes in the brain after lentiviral infection. | impairment of the blood-brain barrier (bbb) has been associated with cognitive decline in many cns diseases, including hiv-associated neurocognitive disorders (hand). recent research suggests an important role for the sonic hedgehog (shh) signaling pathway in the maintenance of bbb integrity under both physiological and pathological conditions. | 2019 | 30981282 |
| antifertility effectiveness of a novel polymer matrix composite and its influence on the endometrium in rhesus macaques (macaca mulatta). | to explored the antifertility effectiveness and influence on the endometrium of a micro-copper/low-density polyethylene/methyl vinyl silicone rubber (cu/ldpe/mvq) composite in rhesus macaques. | 2019 | 30980831 |
| cholecystokinin immunoreactive neurons in the basolateral amygdala of the rhesus monkey (macaca mulatta). | several distinct subpopulations of interneurons (ins) in the amygdalar basolateral nuclear complex (bnc) of the rat can be recognized on the basis of their expression of calcium-binding proteins and neuropeptides, including parvalbumin (pv), somatostatin (som), calretinin (cr), and cholecystokinin (cck). in the rat bnc cck is expressed in two separate in subpopulations, termed large (cckl ) and small (ccks ). these subpopulations exhibit distinct connections indicative of discrete functional rol ... | 2019 | 30980540 |
| preliminary evidence of increased striatal dopamine in a nonhuman primate model of maternal immune activation. | women exposed to a variety of viral and bacterial infections during pregnancy have an increased risk of giving birth to a child with autism, schizophrenia or other neurodevelopmental disorders. preclinical maternal immune activation (mia) models are powerful translational tools to investigate mechanisms underlying epidemiological links between infection during pregnancy and offspring neurodevelopmental disorders. our previous studies documenting the emergence of aberrant behavior in rhesus monke ... | 2019 | 30979867 |
| quantitative ultrasound parameters based on the backscattered echo power signal as biomarkers of cervical remodeling: a longitudinal study in the pregnant rhesus macaque. | clinical prediction and especially prevention of abnormal birth timing, particularly pre-term, is poor. the cervix plays a key role in birth timing; it first serves as a rigid barrier to protect the developing fetus, then becomes the pathway to delivery of that fetus. imaging biomarkers to define this remodeling process could provide insights to improve prediction of birth timing and elucidate novel targets for preventive therapies. quantitative ultrasound (qus) approaches that appear promising ... | 2019 | 30979594 |
| heterologous antibodies adsorption in xenotransplantation of a landrace piglet kidney into a rhesus monkey. | to explore the adsorption of heterologous antibodies in 6 xenotransplants of landrace piglet kidneys into rhesus monkeys. | 2019 | 30979492 |
| decoding movements from cortical ensemble activity using a long short-term memory recurrent network. | although many real-time neural decoding algorithms have been proposed for brain-machine interface (bmi) applications over the years, an optimal, consensual approach remains elusive. recent advances in deep learning algorithms provide new opportunities for improving the design of bmi decoders, including the use of recurrent artificial neural networks to decode neuronal ensemble activity in real time. here, we developed a long-short term memory (lstm) decoder for extracting movement kinematics fro ... | 2019 | 30979355 |
| disentangling the effects of early caregiving experience and heritable factors on brain white matter development in rhesus monkeys. | early social experiences, particularly maternal care, shape behavioral and physiological development in primates. thus, it is not surprising that adverse caregiving, such as child maltreatment leads to a vast array of poor developmental outcomes, including increased risk for psychopathology across the lifespan. studies of the underlying neurobiology of this risk have identified structural and functional alterations in cortico-limbic brain circuits that seem particularly sensitive to these early ... | 2019 | 30978495 |
| working memory representation of empty sets in the primate parietal and prefrontal cortices. | for the brain, representing empty sets as a precursor to zero is a challenge because it requires the active coding of a quantitative category that, by definition, contains no items. recent neurophysiological recordings show that empty sets are distinctively encoded by neurons in the primate ventral intraparietal area (vip) and the prefrontal cortex (pfc). however, how empty sets are represented in working memory is unknown. we simultaneously recorded from vip and pfc while rhesus monkeys perform ... | 2019 | 30975433 |
| characterization of hiv-1 nucleoside-modified mrna vaccines in rabbits and rhesus macaques. | despite the enormous effort in the development of effective vaccines against hiv-1, no vaccine candidate has elicited broadly neutralizing antibodies in humans. thus, generation of more effective anti-hiv vaccines is critically needed. here we characterize the immune responses induced by nucleoside-modified and purified mrna-lipid nanoparticle (mrna-lnp) vaccines encoding the clade c transmitted/founder hiv-1 envelope (env) 1086c. intradermal vaccination with nucleoside-modified 1086c env mrna-l ... | 2019 | 30974332 |
| effects of pregnancy, outdoor access, and antifungal medication on hair loss in breeding-age female pigtailed macaques (macaca nemestrina). | over 18 mo, adult female pigtailed macaques (macaca nemestrina) housed at a breeding facility in arizona were monitored every 6 mo for alopecia. the study period coincided with the movement of a majority of animals from primarily outdoor housing to continuous indoor housing and a corresponding decrease in available space. these changes were made due to the newly recognized prevalence of coccidioidomycosis at this site. the effects of pregnancy status, changes in outdoor access or space, and admi ... | 2019 | 30971325 |
| effects of stimulation of mu opioid and nociceptin/orphanin fq peptide (nop) receptors on alcohol drinking in rhesus monkeys. | alcohol use disorder (aud) persists as a devastating public health problem; widely effective pharmacological treatments are needed. evidence from rodent models suggests that stimulating brain receptors for the neuropeptide nociceptin/orphanin fq (nop) can decrease ethanol drinking. we characterized the effects of the mu opioid peptide (mop) receptor agonist buprenorphine and the buprenorphine analog (2s)-2-[(5r,6r,7r,14s)-n-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6 methoxymorphinan-7-y ... | 2019 | 30970376 |
| hla-e: exploiting pathogen-host interactions for vaccine development. | viruses, when used as vectors for vaccine antigen delivery, can induce strong cellular and humoral responses against target epitopes. recent work by hansen et al. describes the use of a cytomegalovirus-vectored vaccine, which is able to generate a stable effector-memory t cell population at the sites of vaccination in rhesus macaques. this vaccine, targeted towards multiple epitopes in simian immunodeficiency virus (siv), did not induce classical cd8+ t cells. however, non-canonical cd8+ t cell ... | 2019 | 30968409 |
| immunometabolic signatures predict risk of progression to active tuberculosis and disease outcome. | there remains a pressing need for biomarkers that can predict who will progress to active tuberculosis (tb) after exposure to mycobacterium tuberculosis (mtb) bacterium. by analyzing cohorts of household contacts of tb index cases (hhcs) and a stringent non-human primate (nhp) challenge model, we evaluated whether integration of blood transcriptional profiling with serum metabolomic profiling can provide new understanding of disease processes and enable improved prediction of tb progression. com ... | 2019 | 30967866 |
| brain death enhances activation of the innate immune system and leads to reduced renal metabolic gene expression. | brain death (bd)-associated inflammation has been implicated in decreased kidney allograft function and survival, but the underlying mechanisms have not been well distinguished from the conditions of critical care itself. we have developed a clinically translatable model to separate and investigate strategies to improve donor management and critical care. | 2019 | 30964836 |
| in vivo delivery of a dna-encoded monoclonal antibody protects non-human primates against zika virus. | zika virus (zikv) infection is endemic to several world regions, and many others are at high risk for seasonal outbreaks. synthetic dna-encoded monoclonal antibody (dmab) is an approach that enables in vivo delivery of highly potent mabs to control infections. we engineered dmab-zk190, encoding the mab zk190 neutralizing antibody, which targets the zikv e protein diii domain. in vivo-delivered dmab-zk190 achieved expression levels persisting >10 weeks in mice and >3 weeks in non-human primate (n ... | 2019 | 30962164 |
| circulating 11-oxygenated androgens across species. | the androgen precursors, dehydroepiandrosterone (dhea) and dhea sulfate (dheas) are produced in high amounts by the adrenal cortex primarily in humans and a few other primates. the human adrenal also secretes 11-oxygenated androgens (11-oxyandrogens), including 11β-hydroxyandrostenedione (11oha4), 11-ketoandrostenedione (11ka4), 11β-hydroxytestosterone (11oht) and 11-ketotestosterone (11kt), of which 11oht and 11kt are bioactive androgens. the 11-oxyandrogens, particularly 11kt, have been recogn ... | 2019 | 30959151 |
| extrinsic and intrinsic dynamics in movement intermittency. | what determines how we move in the world? motor neuroscience often focusses either on intrinsic rhythmical properties of motor circuits or extrinsic sensorimotor feedback loops. here we show that the interplay of both intrinsic and extrinsic dynamics is required to explain the intermittency observed in continuous tracking movements. using spatiotemporal perturbations in humans, we demonstrate that apparently discrete submovements made 2-3 times per second reflect constructive interference betwee ... | 2019 | 30958267 |
| social affiliation predicts mitochondrial dna copy number in female rhesus macaques. | in many social mammals, social adversity predicts compromised health and reduced fitness. these effects are thought to be driven in part by chronic social stress, but their molecular underpinnings are not well understood. recent work suggests that chronic stress can affect mitochondrial copy number, heteroplasmy rates and function. here, we tested the first two possibilities for the first time in non-human primates. we manipulated dominance rank in captive female rhesus macaques ( n = 45), where ... | 2019 | 30958211 |
| establishment of a novel mesial temporal lobe epilepsy rhesus monkey model via intra-hippocampal and intra-amygdala kainic acid injection assisted by neurosurgical robot system. | mesial temporal lobe epilepsy (mtle) is the most common type of refractory epilepsy, and non-human primate (nhp) models are important to investigate its mechanism and therapy. however, previous mtle-nhp models have some defects. | 2019 | 30954527 |
| quantitative ultrasound and apoptotic death in the neonatal primate brain. | apoptosis is triggered in the developing mammalian brain by sedative, anesthetic or antiepileptic drugs during late gestation and early life. whether human children are vulnerable to this toxicity mechanism remains unknown, as there are no imaging techniques to capture it. apoptosis is characterized by distinct structural features, which affect the way damaged tissue scatters ultrasound compared to healthy tissue. we evaluated whether apoptosis, triggered by the anesthetic sevoflurane in the bra ... | 2019 | 30951850 |
| the cytokine response profile of ebola virus disease in a large cohort of rhesus macaques treated with monoclonal antibodies. | ebola virus (ebov) is a highly pathogenic filovirus that causes outbreaks of a severe hemorrhagic fever known as ebov disease (evd). ebola virus disease is characterized in part by a dysregulated immune response and massive production of both pro- and anti-inflammatory cytokines. to better understand the immune response elicited by evd in the context of treatment with experimental anti-ebov antibody cocktails, we analyzed 29 cytokines in 42 ebov-infected rhesus macaques. in comparison to the sur ... | 2019 | 30949520 |
| neural coding for shape and texture in macaque area v4. | the distinct visual sensations of shape and texture have been studied separately in cortex; therefore, it remains unknown whether separate neuronal populations encode each of these properties or one population carries a joint encoding. we directly compared shape and texture selectivity of individual v4 neurons in awake macaques (1 male, 1 female) and found that v4 neurons lie along a continuum from strong tuning for boundary curvature of shapes to strong tuning for perceptual dimensions of textu ... | 2019 | 30948478 |
| nema nu-4 performance evaluation of a non-human primate animal pet. | the eplus-260 primate pet is an animal pet imaging system developed by the institute of high energy physics, chinese academy of sciences, which is designed to image non-human primates, especially the brain of large non-human primates. the system consists of 48 block detectors arranged in two 24-sided rings with a ring diameter of 263 mm and an axial extent of 64 mm. each block detector is composed of a 16 × 16 cerium-doped lutetium-yttrium orthosilicate crystal array with a pixel size of 1.9 ... | 2019 | 30947155 |
| morphology of inner retina in rhesus monkeys of various ages: a comparative study. | to investigate the changes of thickness in each layer, the morphology and density of inner neurons in rhesus monkeys' retina at various growth stages, thus contribute useful data for further biological studies. | 2019 | 30944733 |
| rational design and in vivo selection of shivs encoding transmitted/founder subtype c hiv-1 envelopes. | chimeric simian-human immunodeficiency viruses (shivs) are an important tool for evaluating anti-hiv env interventions in nonhuman primate (nhp) models. however, most unadapted shivs do not replicate well in vivo limiting their utility. furthermore, adaptation in vivo often negatively impacts fundamental properties of the env, including neutralization profiles. transmitted/founder (t/f) viruses are particularly important to study since they represent viruses that initiated primary hiv-1 infectio ... | 2019 | 30943274 |
| a descriptive analysis of gut microbiota composition in differentially reared infant rhesus monkeys (macaca mulatta) across the first 6 months of life. | the gastrointestinal microbiome is recognized as a critical component in host immune function, physiology, and behavior. early life experiences that alter diet and social contact also influence these outcomes. despite the growing number of studies in this area, no studies to date have examined the contribution of early life experiences on the gut microbiome in infants across development. such studies are important for understanding the biological and environmental factors that contribute to opti ... | 2019 | 30941799 |
| salivary gland neoplasms in non-human primates: a case series and brief literature review. | salivary gland neoplasms are rare in non-human primates. | 2019 | 30941779 |
| a pathogenic role for splenic b1 cells in siv disease progression in rhesus macaques. | b1 cells spontaneously produce protective natural antibodies which provide the first line of defense against a variety of pathogens. although these natural antibodies share similar autoreactive features with several hiv-1 broadly neutralizing antibodies, the role of b1 cells in hiv/siv disease progression is unknown. we report the presence of human-like b1 cells in rhesus macaques. during chronic siv infection, we found that the frequency of splenic cd11b+ b1 cells positively correlated with pla ... | 2019 | 30941141 |
| gammaherpesvirus rnas come full circle. | after an adaptive immune response is mounted, gammaherpesviruses achieve persistence through the utilization of viral noncoding rnas to craft a suitable host cell environment in an immunologically transparent manner. while gammaherpesvirus long noncoding rnas (lncrnas) and micrornas have been recognized for some time and have been actively investigated, a recent spate of reports have now identified repertoires of the circular rna (circrna) class of noncoding rnas in both the lymphocryptovirus an ... | 2019 | 30940699 |
| from rhesus macaque to human: structural evolutionary pathways for immunoglobulin g subclasses. | the old world monkey, rhesus macaque (macaca mulatta, mm), is frequently used as a primate model organism in the study of human disease and to test new vaccines/antibody treatments despite diverging before chimpanzees and orangutans. mm and humans share 93% genome identity with substantial differences in the genes of the adaptive immune system that lead to different functional igg subclass characteristics, fcγ receptors expressed on innate immune cells, and biological interactions. these differe ... | 2020 | 30939981 |
| combination of stem cell and gene therapy ameliorates symptoms in huntington's disease mice. | huntington's disease (hd) is a dominantly inherited monogenetic disorder characterized by motor and cognitive dysfunction due to neurodegeneration. the disease is caused by the polyglutamine (polyq) expansion at the 5' terminal of the exon 1 of the huntingtin (htt) gene, it15, which results in the accumulation of mutant htt (mhtt) aggregates in neurons and cell death. the monogenetic cause and the loss of specific neural cell population make hd a suitable candidate for stem cell and gene therapy ... | 2019 | 30937182 |
| butorphanol-azaperone-medetomidine for the immobilization of rhesus macaques (macaca mulatta). | maximizing animal wellbeing by minimizing drug-related side effects is a key consideration when choosing pharmaceutical agents for chemical restraint in nonhuman primates. one drug combination that may promote this ideology is butorphanol (27.3 mg/ml), azaperone (9.1 mg/ml), and medetomidine (10.9 mg/ml; bam). based on results from a pilot study, 2 doses of bam (16 and 24 μl/kg im) were compared in healthy, 3-y-old rhesus macaques. physiologic parameters and anesthetic quality were assessed and ... | 2019 | 30935442 |
| single-photon emission computed tomography-computed tomography using 99mtc-labeled leukocytes for evaluating infection associated with a cranial implant in a rhesus macaque (macaca mulatta). | an adult male rhesus macaque (macaca mulatta) that was enrolled in a study evaluating cognition and memory presented with suppurative exudate along the margins of a long-standing cranial implant that included a stainless-steel head post, plastic left-sided recording cylinder, and acrylic over a previously placed right-sided recording cylinder. both cylinders were located at the level of the prefrontal cortex. after treatment comprising systemic antibiotics and daily cleaning with povidone-iodine ... | 2019 | 30935441 |
| neuromuscular control pattern in rhesus monkeys during bipedal walking. | walking is characterized by repetitive limb movements associated with highly structured patterns of muscle activity. the causal relationships between the muscle activities and hindlimb segments of walking are difficult to decipher. this study investigated these particular relationships and clarified whether they are correlated with speed to further understand the neuromuscular control pattern. four adult female rhesus monkeys (macaca mulatta) were selected to record gait parameters while walking ... | 2019 | 30930341 |
| repeated retinal photocoagulation in monkeys for the optimization of a laser-induced choroidal neovascularization model. | the laser-induced choroidal neovascularization (cnv) model in nonhuman primates has played a critical role in the development of new therapies for neovascular age-related macular degeneration. the widespread use of this model, however, has been limited by its high costs, mainly due to the lower efficiency of animal use. we optimized the cnv model by administering repeated photocoagulation treatments to the same eye of each animal, and preliminarily evaluated this model using an assessment of the ... | 2019 | 30928489 |
| evolution of brain connections: integrating diffusion mr tractography with gene expression highlights increased corticocortical projections in primates. | diffusion mr tractography permits investigating the 3d structure of cortical pathways as interwoven paths across the entire brain. we use high-resolution scans from diffusion spectrum imaging and high angular resolution diffusion imaging to investigate the evolution of cortical pathways within the euarchontoglire (i.e., primates, rodents) lineage. more specifically, we compare cortical fiber pathways between macaques (macaca mulatta), marmosets (callithrix jachus), and rodents (mice, mus musculu ... | 2019 | 30927350 |
| shifting dynamics of intestinal macrophages during simian immunodeficiency virus infection in adult rhesus macaques. | the intestinal tract is a primary barrier to invading pathogens and contains immune cells, including lymphocytes and macrophages. we previously reported that cd163+cd206- (single-positive [sp]) interstitial macrophages of the lung are short-lived and succumb early to siv infection. conversely, cd163+cd206+ (double-positive [dp]) alveolar macrophages are long-lived, survive after siv infection, and may contribute to the virus reservoir. this report characterizes analogous populations of macrophag ... | 2019 | 30926643 |
| enhanced wound healing promotion by immune response-free monkey autologous ipscs and exosomes vs. their allogeneic counterparts. | comparing non-inbred autologous and allogeneic induced pluripotent stem cells (ipscs) and their secreted subcellular products among non-human primates is critical for choosing optimal ipsc products for human clinical trials. | 2019 | 30926422 |
| il-33 enhances the kinetics and quality of the antibody response to a dna and protein-based hiv-1 env vaccine. | induction of a sustained and broad antibody (ab) response is a major goal in developing a protective hiv-1 vaccine. dna priming alone shows reduced levels of immunogenicity; however, when combined with protein boosting is an attractive vaccination strategy for induction of humoral responses. using the vc10014 dna and protein-based vaccine consisting of hiv-1 envelope (env) gp160 plasmids and trimeric gp140 proteins derived from an hiv-1 clade b infected subject who developed broadly neutralizing ... | 2019 | 30926296 |
| opportunities for refinement in neuroscience: indicators of wellness and post-operative pain in laboratory macaques. | being able to assess pain in nonhuman primates undergoing biomedical procedures is important for preventing and alleviating pain, and for developing better guidelines to minimise the impacts of research on welfare in line with the 3rs principle of refinement. nonhuman primates are routinely used biomedical models however it remains challenging to recognise negative states, including pain, in these animals. this study aimed to identify behavioural and facial changes that could be used as pain or ... | 2019 | 30924506 |
| modified dose efficacy trial of a canine distemper-measles vaccine for use in rhesus macaques (macaca mulatta). | measles virus causes a highly infectious disease in nhp. clinical signs range from asymptomatic to fatal, although measles virus is most well-known for its characteristic generalized maculopapular rash. along with appropriate quarantine practices, restricted human access, and appropriate personal protective equipment, vaccines are used to combat the risk of infection. the canine distemper-measles vaccine (cdmv), administered at the manufacturer's standard dose (1.0 ml im), has been shown to be e ... | 2019 | 30922419 |
| time matching between grooming partners: do methodological distinctions between short versus long-term reciprocation matter? | primatologists have long focused on grooming exchanges to examine aspects of social relationships, co-operation, and social cognition. one particular interest is the extent to which reciprocating grooming partners time match, and the time frame over which they do so. conclusions about time matching vary across species. generally, researchers focus on the duration of pauses between grooming episodes that involve a switch in partner roles and choose a cut-off point to distinguish short from longer ... | 2019 | 30919475 |
| bu10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates. | the marked increase in mis-use of prescription opioids has greatly affected our society. one potential solution is to develop improved analgesics which have agonist action at both mu opioid peptide (mop) and nociceptin/orphanin fq peptide (nop) receptors. bu10038 is a recently identified bifunctional mop/nop partial agonist. the aim of this study was to determine the functional profile of systemic or spinal delivery of bu10038 in primates after acute and chronic administration. | 2019 | 30916003 |
| responses of neurons in lateral intraparietal area depend on stimulus-associated reward during binocular flash suppression. | discovering neural correlates of subjective perception and dissociating them from sensory input has fascinated neuroscientists for a long time. bistable and multistable perception phenomena have exhibited great experimental potential to address this question. here, we performed electrophysiological recordings from single neurons in lateral intraparietal area (lip) of rhesus macaques during stimulus and perceptual transitions induced by binocular flash suppression (bfs). lip neurons demonstrated ... | 2019 | 30914928 |
| exploring the jastrow illusion in humans ( homo sapiens), rhesus monkeys ( macaca mulatta), and capuchin monkeys ( sapajus apella). | in the jastrow size illusion, two vertically stacked but offset stimuli of identical size are misperceived such that the bottom stimulus is overestimated relative to the top stimulus due to their spatial layout. in this study, we explored whether nonhuman primates perceive this geometric illusion in the same manner as humans. human adults, rhesus macaques, and capuchin monkeys were presented with a computerized size discrimination task including jastrow illusion probe trials. consistent with pre ... | 2019 | 30913960 |
| irisin in the primate hypothalamus and its effect on gnrh in vitro. | irisin, encoded by the fndc5 gene, is a recently discovered endocrine factor mainly secreted as a myokine and adipokine. however, irisin/fndc5 expression has also been reported in different other organs including components of the reproductive axis. yet, there is the scarcity of data on fndc5/irisin expression, regulation and its reproductive effects, particularly in primates. here, we report the expression of fndc5/irisin, along with pgc1a (peroxisome proliferator-activated receptor gamma coact ... | 2019 | 30913538 |
| in situ hybridization assay for the diagnosis of chagas myocarditis and orchitis in a rhesus macaque (macaca mulatta): a case report. | we present the first documented case of trypanosoma cruzi-induced orchitis in a rhesus macaque. additionally, we describe an in situ hybridization-based assay to confirm t. cruzi infection in formalin-fixed tissues. | 2019 | 30912150 |
| zeptomole per milliliter detection and quantification of edema factor in plasma by lc-ms/ms yields insights into toxemia and the progression of inhalation anthrax. | inhalation of bacillus anthracis spores can cause a rapidly progressing fatal infection. b. anthracis secretes three protein toxins: lethal factor (lf), edema factor (ef), and protective antigen (pa). ef and lf may circulate as free or pa-bound forms. both free ef (ef) and pa-bound-ef (etx) have adenylyl cyclase activity converting atp to camp. we developed an adenylyl cyclase activity-based method for detecting and quantifying total ef (ef+etx) in plasma. the three-step method includes magnetic ... | 2019 | 30911800 |
| chronic phencyclidine treatment impairs spatial working memory in rhesus monkeys. | phencyclidine (pcp) could induce schizophrenia (sz) like behavior in both humans and animals, therefore, has been widely utilized to establish sz animal models. it induced cognitive deficits, the core symptom of sz, mainly through influencing frontal dopaminergic function. nonhuman primate (nhp) studies demonstrated impaired object retrieval detour (ord) and spatial delayed response (sdr) task performance by acute or chronic pcp treatment. however, nhp investigations, continually monitoring sdr ... | 2019 | 30911792 |
| heightened defensive responses following subtotal lesions of macaque orbitofrontal cortex. | anxiety disorders are characterized by excessive attention to threat. several brain areas, including the orbitofrontal cortex (ofc), have been associated with threat processing, with more recent work implicating specialized roles for the medial and lateral subregions of the ofc in mediating specific symptoms of anxiety disorders. virtually no causal work, however, has evaluated the role of these ofc subregions in regulating behavioral responses under threat. to address this gap, we compared male ... | 2019 | 30910790 |
| chronic glucocorticoid exposure induces depression-like phenotype in rhesus macaque (macaca mulatta). | it has long been observed in humans that the occurrence of depressive symptoms is often accompanied by the dysfunction of hypothalamic-pituitary-adrenal (hpa) axis. the rodent experiments also showed that chronic corticosterone exposure could induce depression-like phenotype. however, rodents are phylogenetically distant from humans. in contrast, non-human primates bear stronger similarities with humans, suggesting research on primates would provide an important complement. for the first time, w ... | 2019 | 30906247 |
| alcohol-induced changes in the gut microbiome and metabolome of rhesus macaques. | increasing evidence has demonstrated that changes in the gut microbiome, including those associated with dietary influences, are associated with alterations in many physiological processes. alcohol consumption is common across human cultures and is likely to have a major effect on the gut microbiome, but there remains a paucity of information on its effects in primates. | 2019 | 30903211 |
| autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring. | testicular tissue cryopreservation is an experimental method to preserve the fertility of prepubertal patients before they initiate gonadotoxic therapies for cancer or other conditions. here we provide the proof of principle that cryopreserved prepubertal testicular tissues can be autologously grafted under the back skin or scrotal skin of castrated pubertal rhesus macaques and matured to produce functional sperm. during the 8- to 12-month observation period, grafts grew and produced testosteron ... | 2019 | 30898927 |
| mixed malignant pancreatic tumour in a rhesus macaque (macaca mullata). | pancreatic islet cell tumours are rare in non-human primates. the majority of reported cases are benign islet cell adenomas in rhesus macaques (macaca mullata). here we describe a pancreatic tumour composed of both exocrine and endocrine cells known as a mixed acinar-neuroendocrine carcinoma in a captive rhesus macaque. a diagnosis of a mixed tumour requires intermingling of neoplastic exocrine and neuroendocrine cells and must be differentiated from ductal adenocarcinomas in which only the duct ... | 2019 | 30898297 |
| limited evidence of number-space mapping in rhesus monkeys (macaca mulatta) and capuchin monkeys (sapajus apella). | humans exhibit evidence of a mental number line that suggests a left-to-right, or sometimes right-to-left, representation of smaller to larger numbers. the spatial numerical association of response codes (snarc) effect is one example of this mental number line and has been investigated extensively in humans. less research has been done with animals, and results have been inconclusive. rugani, vallortigara, priftis, and regolin (2015) found that young chicks showed a bias to respond to small quan ... | 2019 | 30896233 |
| non-invasive eye tracking methods for new world and old world monkeys. | eye-tracking methods measure what humans and other animals visually attend to in the environment. in nonhuman primates, eye tracking can be used to test hypotheses about how primates process social information. this information can further our understanding of primate behavior as well as offer unique translational potential to explore causes of or treatments for altered social processing as seen in people with neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. howev ... | 2019 | 30890923 |
| multivariate profiling of african green monkey and rhesus macaque t lymphocytes. | the complexity of immune responses limits the usefulness of univariate methods in answering complex immunology questions. to demonstrate the utility of a multivariate approach, we employ such approach to compare t cells of african green monkeys (agms) and rhesus macaques (rms). among the most prominent distinguishing features we found were lower cd3 and higher cd28 surface expression in agms compared to rms. after in vitro stimulation, a larger proportion of agm t cells secreted cytokines, espec ... | 2019 | 30886198 |
| microbiome profiles of ligature-induced periodontitis in nonhuman primates across the life span. | this investigation compared the microbiomes colonizing teeth during the initiation, progression, and resolution of periodontitis in nonhuman primates (macaca mulatta) at different ages. subgingival plaque samples were collected at baseline; 0.5, 1, and 3 months following ligature-induced periodontitis; and following naturally occurring disease resolution at 5 months. samples were analyzed using 16s amplicon sequencing to identify bacterial profiles across age groups: young (<3 years of age), ado ... | 2019 | 30885927 |
| fecal metatranscriptomics of macaques with idiopathic chronic diarrhea reveals altered mucin degradation and fucose utilization. | idiopathic chronic diarrhea (icd) is a common cause of morbidity and mortality among juvenile rhesus macaques. characterized by chronic inflammation of the colon and repeated bouts of diarrhea, icd is largely unresponsive to medical interventions, including corticosteroid, antiparasitic, and antibiotic treatments. although icd is accompanied by large disruptions in the composition of the commensal gut microbiome, no single pathogen has been concretely identified as responsible for the onset and ... | 2019 | 30885266 |
| effects of ketamine treatment on cocaine-induced reinstatement and disruption of functional connectivity in unanesthetized rhesus monkeys. | substance use disorders are characterized by a loss of executive control over reward-based decision-making, and disruption of fronto-striatal connectivity has been implicated in this process. sub-anesthetic ketamine has recently been shown to bolster fronto-striatal connectivity in drug-naïve subjects. | 2019 | 30879118 |
| cd8+ t cell-based strong selective pressure on multiple simian immunodeficiency virus targets in macaques possessing a protective mhc class i haplotype. | in human immunodeficiency virus (hiv) and simian immunodeficiency virus (siv) infections, host major histocompatibility complex class i (mhc-i) genotypes have a great impact on viral replication and mhc-i-associated viral genome mutations are selected under cd8+ t-cell pressure. association of mhc-i genotypes with hiv/siv control has been investigated at mhc-i allele levels but not fully at haplotype levels. we previously established groups of rhesus macaques sharing individual mhc-i haplotypes. ... | 2019 | 30878187 |
| [stimulation of cognitive abilities in aged macaques by moderate hypobaric hypoxia.] | the importance of studying neurological and mental changes in aged non-human primates, in particular rhesus macaques (macaca mulatta), is due to their genetic and physiological similarity with humans, which in preclinical studies of age-dependent cognitive decline correction makes them preferable to rodents. in this paper we study the behavior of three older monkeys in solving conditioned-reflex task of image differentiation. the obtained values of several cognitive characteristics were compared ... | 2019 | 30877829 |
| higher offspring mortality with short interbirth intervals in free-ranging rhesus macaques. | short birth intervals have long been linked to adverse child outcomes in humans. however, it remains unclear the extent to which the birth interval has a direct influence on offspring mortality, independent of the confounding effects of modern environments and human sociocultural practices on reproductive behavior. outside of humans, the relationship between birth intervals and offspring mortality has been rarely tested, leaving an open question of how much the findings from humans imply evoluti ... | 2019 | 30877247 |
| immune and cytokine/chemokine responses of pbmcs in rotavirus-infected rhesus infants and their significance in viral pathogenesis. | the rotavirus (rv) is the most important causative agent of severe gastroenteritis in infants and children aged less than 5 years worldwide. however, the response and the roles of peripheral blood mononuclear cell (pbmc) in rv clearance have yet to be fully elucidated. in this study, we established the neonatal rhesus monkey model of rv infection with histopathological changes in the small intestine. then, we investigated gene expression changes in pbmcs from the monkey model of rv infection. si ... | 2019 | 30875452 |
| ultrapotent chemogenetics for research and potential clinical applications. | chemogenetics enables noninvasive chemical control over cell populations in behaving animals. however, existing small-molecule agonists show insufficient potency or selectivity. there is also a need for chemogenetic systems compatible with both research and human therapeutic applications. we developed a new ion channel-based platform for cell activation and silencing that is controlled by low doses of the smoking cessation drug varenicline. we then synthesized subnanomolar-potency agonists, call ... | 2019 | 30872534 |
| hiv-1 tat-mediated microglial inflammation involves a novel mirna-34a-nlrc5-nfκb signaling axis. | while the advent of combination antiretroviral therapy (cart) has dramatically increased the lifespan of people living with hiv-1 paradoxically, the prevalence of neurohiv in people treated with cart is on the rise. it has been well documented that despite the effectiveness of cart in suppressing viremia, cns continues to harbor viral reservoirs with persistent low-level virus replication. this, in turn, leads to the presence and accumulation of early viral protein - hiv-1 tat, that is a well-es ... | 2019 | 30872089 |
| hematological effects of non-homogenous ionizing radiation exposure in a non-human primate model. | detonation of a radiological or nuclear device in a major urban area will result in heterogenous radiation exposure, given to the significant shielding of the exposed population due to surrounding structures. development of biodosimetry assays for triage and treatment requires knowledge of the radiation dose-volume effect for the bone marrow (bm). this proof-of-concept study was designed to quantify bm damage in the non-human primate (nhp) after exposure to one of four radiation patterns likely ... | 2019 | 30870098 |
| behavioral effects of postnatal ketamine exposure in rhesus macaque infants are dependent on maoa-lpr genotype. | ketamine is an n-methyl-d-aspartate (nmda) receptor antagonist widely used in pediatric anesthetic and therapeutic practices and veterinary medicine. previous evidence suggests that exposure to ketamine during sensitive periods of development results in neural apoptosis and atypical behavior. since monoamine neurotransmitters play important roles in prenatal and early postnatal neural development, and since previous work suggests ketamine can inhibit monoamine transporters, we hypothesized that ... | 2019 | 30868562 |
| design and characterization of cholesterylated peptide hiv-1/2 fusion inhibitors with extremely potent and long-lasting antiviral activity. | hiv infection requires lifelong treatment with multiple antiretroviral drugs in a combination, which ultimately causes cumulative toxicities and drug resistance, thus necessitating the development of novel antiviral agents. we recently found that enfuvirtide (t-20)-based lipopeptides conjugated with fatty acids have dramatically increased in vitro and in vivo anti-hiv activities. herein, a group of cholesterol-modified fusion inhibitors were characterized with significant findings. first, novel ... | 2019 | 30867304 |
| erratum: correction of classification: rise of the visible monkey: sectioned images of rhesus monkey. | [this corrects the article e66 in vol. 34, pmid: 30833883.]. | 2019 | 30863270 |
| evaluation of a new balloon for fetal endoscopic tracheal occlusion in the nonhuman primate model. | we developed a new balloon called "smart-to," which allows noninvasive and easy unplugging, thanks to a magnetic valve actuated by the magnetic fringe field of a magnetic resonance imaging (mri) scanner. the objective of this feasibility study was to evaluate the operation of this new balloon in a nonhuman primate model. | 2019 | 30861154 |
| gabaa receptor subtypes and the abuse-related effects of ethanol in rhesus monkeys: experiments with selective positive allosteric modulators. | previous studies have investigated α1gabaa and α5gabaa receptor mechanisms in the behavioral effects of ethanol (etoh) in monkeys. however, genetic studies in humans and preclinical studies with mutant mice suggest a role for α2gabaa and/or α3gabaa receptors in the effects of etoh. the development of novel positive allosteric modulators (pams) with functional selectivity (i.e., selective efficacy) at α2gabaa and α3gabaa receptors allows for probing of these subtypes in preclinical models of the ... | 2019 | 30861153 |
| tolerance and dependence to δ9-tetrahydrocannabinol in rhesus monkeys: activity assessments. | cannabis withdrawal upon discontinuation of long-term, heavy cannabis use is reported in humans; however, methods to establish the nature and intensity of cannabinoid withdrawal, especially directly observable signs, have not been widely established. this study quantified activity in the home cage of rhesus monkeys and examined the extent to which activity can be used to quantify tolerance to and dependence on δ9-tetrahydrocannabinol (δ9-thc). home-cage activity was measured in one group that re ... | 2019 | 30861005 |
| polymorphisms in the apobec3g gene of chinese rhesus macaques affect resistance to ubiquitination and degradation mediated by hiv-2 vif. | animal cells have multiple innate effector mechanisms that inhibit viral replication. for the pathogenic retrovirus human immunodeficiency virus 1 (hiv-1), there are widely expressed restriction factors, such as apobec3 proteins, tetherin/bst2, samhd1 and mx2, as well as trim5α. we previously found that the trim5α gene clearly affects sivmac or hiv-2 replication, but the major determinant of the combinatorial effect caused by multiple host restriction factors is still not fully clear. apobec3g ( ... | 2019 | 30859472 |
| multisensory neurons in the primate amygdala. | animals identify, interpret, and respond to complex, natural signals that are often multisensory. the ability to integrate signals across sensory modalities depends on the convergence of sensory inputs at the level of single neurons. neurons in the amygdala are expected to be multisensory because they respond to complex, natural stimuli, and the amygdala receives inputs from multiple sensory areas. we recorded activity from the amygdala of 2 male monkeys (macaca mulatta) in response to visual, t ... | 2019 | 30858163 |
| a novel dopamine d1 receptor agonist excites delay-dependent working memory-related neuronal firing in primate dorsolateral prefrontal cortex. | decades of research have emphasized the importance of dopamine (da) d1 receptor (d1r) mechanisms to dorsolateral prefrontal cortex (dlpfc) working memory function, and the hope that d1r agonists could be used to treat cognitive disorders. however, existing d1r agonists all have had high affinity for d1r, and engage β-arrestin signaling, and these agonists have suppressed task-related neuronal firing. the current study provides the first physiological characterization of a novel d1r agonist, pf-3 ... | 2019 | 30858103 |
| α-synuclein expression is preserved in substantia nigra gabaergic fibers of young and aged neurotoxin-treated rhesus monkeys. | α-synuclein (α-syn) is a small presynaptic protein distributed ubiquitously in the central and peripheral nervous system. in normal conditions, α-syn is found in soluble form, while in parkinson's disease (pd) it may phosphorylate, aggregate, and combine with other proteins to form lewy bodies. the purpose of this study was to evaluate, in nonhuman primates, whether α-syn expression is affected by age and neurotoxin challenge. young adult (n = 5, 5-10 years old) and aged (n = 4, 23-25 years old) ... | 2019 | 30857404 |
| adeno-associated virus delivery of anti-hiv monoclonal antibodies can drive long-term virologic suppression. | long-term delivery of anti-hiv monoclonal antibodies (mabs) using adeno-associated virus (aav) vectors holds promise for the prevention and treatment of hiv infection. we describe a therapy trial in which four rhesus monkeys were infected with shiv-ad8 for 86 weeks before receiving the aav-encoded mabs 3bnc117, 10-1074, and 10e8. although anti-drug antibody (ada) responses restricted mab delivery, one monkey successfully maintained 50-150 μg/ml of 3bnc117 and 10-1074 for over 2 years. delivery o ... | 2019 | 30850342 |