Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| dna synthesis without mitosis in amputated denervated forelimbs of larval axolotls. | 1974 | 4436617 | |
| [histochemical study comparing the activity of delta5-3beta -hydroxysteroid dehydrogenase of the testicle of the normal axolotl with that transplanted into a male or female host]. | 1974 | 4430443 | |
| lactate dehydrogenase isozymes before and after initiation of the heartbeat in embryos of the mexican axolotl. | 1974 | 4417959 | |
| ion and water balance in normal and mutant fluid imbalanced (ff) embryos of the axolotl (ambystoma mexicanum). | 1971 | 4401104 | |
| [localisation by immunofluorescence of secretions related to thyreotropins, gonadotropins and corticotropins in axolotl pituitary(ambystoma mexicanum, shaw (author's transl)]. | 1973 | 4358329 | |
| ultimobranchial gland ultrastructure of larval axolotls, ambystoma mexicanum shaw, with some observations on the newt, pleurodeles waltlii micahelles. | 1972 | 4346500 | |
| [experimental studies on enzyme histochemical changes in the olfactory system of ambystoma mexicanum following unilateral resection of the olfactory organ]. | 1971 | 4340526 | |
| a new method of housing axolotls and other aquatic amphibians. | 1971 | 4322770 | |
| [enzyme maturation in the smell organ and telencephalon of ambystoma mexicanum]. | 1970 | 4320396 | |
| [heterogeneity of the thyroid gland: morphological study of the gland of the axolotl (ambystoma mexicanum)]. | 1971 | 4258391 | |
| [determination, by tritiated thymidine incorporation, of the stages of cellular cycle in the axolotl germ in synchronous period of segmentation]. | 1974 | 4218510 | |
| [interspecific nucleocytoplasmic hybridization produced by nuclear graft between the species ambystoma mexicanum shaw and ambystoma dumerilii, duges urodela amphibians]. | 1974 | 4216429 | |
| [development of gonads transplanted into the limb. axolotl. effect of castration of the host animals]. | 1974 | 4216428 | |
| the role of trh in the neoteny of the mexican axolotl (ambystoma mexicanum). | 1974 | 4214731 | |
| effect of tsh and long-acting thyroid stimulator on thyroid 131i-metabolism and metamorphosis of the mexican axolotl (ambystoma mexicanum). | 1974 | 4214730 | |
| ontogeny and localization of gamma-crystallins in rana temporaria, ambystoma mexicanum and pleurodeles waltlii normal lens development. | 1974 | 4214710 | |
| the effect of ascorbic acid and potassium ferricyanide as melanogenesis inhibitors on the development of pigmentation in mexican axolotls. | 1974 | 4207619 | |
| [allophenic intergeneric chimera between pleurodeles waltlii michah and ambystoma mexicanum shaw. (amphibia, urodeles). demonstration of tegument chimerism]. | 1973 | 4202593 | |
| [influence of experimental metamorphosis on plasma and erythrocyte lactic dehydrogenase isoenzymes in ambystoma mexicanum shaw]. | 1973 | 4202592 | |
| [development of gonads transplanted in the axolotl limb, as a function of the sex of the host. ovary]. | 1973 | 4196411 | |
| [light and electron microscopical studies on the taste bud of neotene axolotls (siredon mexicanum shaw)]. | 1967 | 4176062 | |
| immunologic responses in the axolotl, siredon mexicanum. | 1967 | 4166021 | |
| [topochemical proof of glycogen formation in the neurula stage of axolotl eggs]. | 1965 | 4158377 | |
| iron kinetics in axolotls (siredon mexicanum). | 1973 | 4146110 | |
| the inheritance of cell differentiation during limb regeneration in the axolotl. | 1974 | 4140121 | |
| ultrastructure of pigment cells in wild type and color mutants of the mexican axolotl. | 1974 | 4140038 | |
| [prolactin enhancement of absorption of sodium ions in isolated gills from larva of ambystoma mexicanum]. | 2014 | 4120136 | |
| interaction of cells of wolffian duct and mesothelium during initial growth period of mullerian ducts in the axolotl (ambystoma mexicanum). | 2007 | 4117072 | |
| [effect of prolactin on sodium retention in intact and hypophysectomized ambystoma mexicanus (axolotl)]. | 1972 | 4114885 | |
| the reactions to carcinogens in the axolotl (ambystoma mexicanum) in relation to the "regeneration field control" hypothesis. | 1971 | 4111936 | |
| [the melanocytes of the axolotl. their modifications during skin regeneration]. | 1971 | 4109990 | |
| an analysis of protein synthesis patterns during early embryogenesis of the urodele--ambystoma mexicanum. | changes in protein synthesis during early ambystoma mexicanum (axolotl) embryogenesis were monitored using two-dimensional (2-d) polyacrylamide gel electrophoresis. no change in synthesis patterns during progesterone-induced oocyte maturation was detected. in oocytes matured in vivo (unfertilized eggs), however, the synthesis of several oogenetic proteins ceased, only to be resumed later in development. at fertilization, one novel non-oogenetic protein was found. a cleavage-specific protein was ... | 1985 | 4093754 |
| regeneration from isolated half limbs in the upper arm of the axolotl. | a technique enabling the isolation of half limb stumps using strips of skin from the head is described. using this technique posterior, dorsal and ventral halves of the upper arms of axolotls were constructed. all halves produced regenerates and regional differences were shown in the regenerative and regulative abilities of the different halves. posterior half stumps regenerated limbs with a mean digit number of 3.9 and had a normal dorsoventral muscle pattern. anterior halves produced hypomorph ... | 1985 | 4093751 |
| banding differences between tiger salamander and axolotl chromosomes. | the hoechst 33258 - giemsa banding patterns were compared on axolotl (ambystoma mexicanum shaw) and axolotl - tiger salamander (ambystoma tigrinum green) species hybrid prophase chromosomes. approximately 369 bands per haploid chromosome set were seen in the axolotl and about 344 bands in the tiger salamander. in the haploid set of 14 chromosomes, chromosome 3 has a constant short or q-arm terminal constriction at the location of the nucleolar organizer. chromosomes 14 z and w carry the sex dete ... | 1985 | 4063874 |
| molecular duality of dna ligase in axolotl corresponds to distinctive transcriptional information. | based upon the use of specific antibodies and sucrose gradient sedimentation analysis, the present work describes the use of the post-transcriptional equipment of the urodele egg to compare the information contained in two rna samples extracted from respectively liver and activated axolotl eggs. it is shown that besides the normal dna ligase activity present in the host pleurodeles eggs, rna can translate for the specific carried information revealing a difference between the two samples. moreov ... | 1985 | 4054231 |
| regeneration of axolotl hindlimbs bearing surgically created discontinuities in the anterior-posterior axis. | the pattern regulation process in amphibian limbs has been examined with respect to the presence of discontinuities in the anterior-posterior (a-p) axis. limbs bearing such discontinuities were surgically created by contralateral exchange of either dorsal or ventral half thighs and these limbs were then amputated immediately after surgery. the results demonstrate that a-p discontinuities lead to the formation of extra limb structures during distal outgrowth in contrast to the mosaic behaviour of ... | 1985 | 4031745 |
| eye enucleation and regeneration of neural retina in axolotl larvae (ambystoma mexicanum). | the eyes of axolotl larvae were enucleated at stages 30 and 37. animals with single dorsomedian eyes resulted in the first case (i.e. stage 30). when a piece of pigment epithelium was re-implanted into stage 37 animals at the site of the lesion, limited regeneration was observed when the implant formed a vesicle, but, when the pigment epithelium remained "open" regeneration of the neural retina was extensive. the possible resons for this difference was discussed. | 1985 | 4014704 |
| a three-step scheme for gray crescent formation in the rotated axolotl oocyte. | it has been shown that various inhibitors of protein synthesis can elicit the precocious appearance of a gray crescent (gc) in in vitro maturing, nonactivated ambystoma mexicanum oocytes. however, evidence has now been obtained that these treatments fail to induce gc formation when the oocytes are enucleated before initiation of maturation. the ability to form a gc is reestablished in enucleated oocytes by the injection of nucleoplasm from a normal oocyte, either before or after the injection of ... | 1985 | 4007261 |
| peanut lectin receptors in the early amphibian embryo: regional markers for the study of embryonic induction. | the regional and temporal specificity of peanut agglutinin binding was determined for early amphibian embryos. with the onset of neurulation, a receptor appears on the epidermis, but remains absent from the neural plate. a second type of receptor, largely masked by sialic acid, appears throughout the extracellular matrix. in the axolotl, the epidermal receptor is epimucin and the matrix receptor is fibronectin plus other components. both receptors are autonomously expressed, on schedule, by appr ... | 1985 | 3995583 |
| neural fold and neural crest movement in the mexican salamander ambystoma mexicanum. | in studies of amphibian neurulation, the terms "neural ridge," "neural fold," and "neural crest" are sometimes used as synonyms. this has occasionally led to the misconception that grafting of the neural crest is equivalent to grafting of the neural fold. the neural fold, however, is composed of three parts: the neural crest, prospective neural tube tissue, and epidermis. in order to investigate how these neural fold components move during neurulation, time-lapse photography, electron microscopy ... | 1985 | 3989498 |
| cellular behavior in the anteroposterior axis of the regenerating forelimb of the axolotl, ambystoma mexicanum. | cellular behavior along the anteroposterior axis of the regenerating axolotl forelimb was studied by use of triploid (3n) tissue grafted into diploid (2n) hosts and three-dimensional computer reconstructions. asymmetrical upper forelimbs were surgically constructed with one half (anterior or posterior) 3n and the other half 2n. limbs were amputated immediately after grafting or were permitted to heal for 5 or 30 days prior to amputation. when regenerates had attained the stage of digital outgrow ... | 1985 | 3987961 |
| developmental mutants isolated from wild-caught xenopus laevis by gynogenesis and inbreeding. | xenopus laevis obtained from indigenous african populations are a rich source of mutants affecting development. gynogenesis and inbreeding were used to isolate mutants affecting development from wild-caught xenopus laevis females. fourteen mutants were recovered from eight females tested. one mutant was recovered from each of two females. this load of 1.875 developmental mutants per female is similar to that found in the axolotl (ambystoma mexicanum), a urodele amphibian, and is only slightly le ... | 1985 | 3973558 |
| stimulation of initial neural crest cell migration in the axolotl embryo by tissue grafts and extracellular matrix transplanted on microcarriers. | the present experiments were designed to test whether the onset of neural crest cell migration in the embryonic axolotl trunk is stimulated by surrounding tissues and their associated extracellular matrix (ecm). tissue grafts, or embryonic ecm adsorbed in vivo onto inert "microcarriers" prepared from nuclepore filters, were placed close to the premigratory neural crest cells, and the embryos were then incubated to a specific stage. the experiments were evaluated with light microscopy, sem, and t ... | 1985 | 3972165 |
| experimental evidence for a proteinaceous presegmental wave required for morphogenesis of axolotl mesoderm. | mesoderm of axolotl embryos at various developmental stages was briefly exposed to a calcium-free 0.01% trypsin solution by temporary removal of the epidermis. this treatment was found to disrupt somite segmentation in a localized region and the pronephric duct was unable to migrate through this region. the affected area, consisting of 3.91 +/- 1.04 somites, traveled through the embryo in synchrony with, and 3.55 +/- 0.69-somite widths ahead of segmentation. trypsinization in the presence of 340 ... | 1985 | 3965323 |
| retinoic acid modifies positional memory in the anteroposterior axis of regenerating axolotl limbs. | the effects of retinoic acid (ra) on anteroposterior (ap) positional memory of regenerating axolotl limbs were tested after removing the anterior or posterior half from the zeugopodium (lower arm or leg). ra (150 micrograms/g body wt) was injected into groups of animals bearing the following types of limbs: (1) anterior and posterior half zeugopodia grafted to the eyesocket and amputated distally 7 days later; (2) unamputated anterior and posterior half zeugopodia in situ; (3) double anterior an ... | 2014 | 3956861 |
| regional specificity of glycoconjugates in xenopus and axolotl embryos. | this paper reviews work on the presence, synthesis and developmental regulation of glycoconjugates (proteoglycans, glycoproteins and glycolipids) in the early amphibian embryo. in the axolotl there is little regional specificity of protein synthesis until the tailbud stage, but substantial regional specificity of glycoprotein synthesis from the end of gastrulation. glycolipid synthesis is more uniform although a number of unique species are made in the epidermis. isolated explants from axolotl e ... | 1985 | 3913731 |
| retinoids and the control of pattern in regenerating limbs. | it has recently been discovered that, as well as having effects on cell division and differentiation, retinoids induce dramatic changes in the development of pattern in limbs. local application of retinoic acid to the anterior side of chick limb buds causes anteroposterior mirror-imaging such that the limb has six digits instead of three. in rana limb buds retinoids induce changes in both the anteroposterior and proximodistal axes. in regenerating axolotl limbs their effect is primarily on the p ... | 1985 | 3896698 |
| histological analysis of limb regeneration in postmetamorphic adult ambystoma. | previous investigation into the regenerative ability of postmetamorphic adult land phase ambystoma has revealed that these species have the capacity to completely regenerate a limb, given optimal environmental conditions, and the gross morphological characteristics of limb regeneration in these species compared favorably with the external regeneration morphology of aquatic phase forms. the present study concerns a histological and histochemical examination of the regenerating limb tissues and th ... | 1985 | 3842040 |
| towards understanding paternal extragenic contributions to early amphibian pattern specification: the axolotl ts-1 gene as a model system. | as a model system for understanding the role sperm extragenic components might play in early embryogenesis the genetics and phenotype of the ts-1 axolotl (ambystoma mexicanum) mutant gene are reviewed. that mutant gene displays parental effects. it exhibits both maternal (egg-mediated) as well as paternal (sperm-mediated) phenotypic effects. a variety of possible modes of action of the ts-1 gene are reviewed. comparisons of various precedents to the ts-1 genetic data are made. in addition, novel ... | 1985 | 3841668 |
| a quantitative analysis of regeneration from chimaeric limb stumps in the axolotl. | we have analysed the cellular contribution and cellular displacement which occur during regeneration from chimaeric (half triploid, half diploid) lower arms in the axolotl. in general both anterior and posterior halves contribute approximately 50% of the regenerated limb cells. deviations from equal contribution were observed only when anterior tissue was grafted, suggesting that anterior tissue is more sensitive to grafting operations. approximately 25% of all cells in the regenerated limb were ... | 1985 | 3834023 |
| urodele egg jelly and fertilization. | fertilization of urodele amphibians is physiologically polyspermic. these amphibians lack sperm entry blocking mechanisms at the egg surface, such as a cortical reaction or a membrane depolarization. although, egg jelly is necessary for sperm capacitation, a late block to sperm entry does occur about 30 min after fertilization at a precise interface between jelly layers. the jelly is secreted by oviductal cells. in order to investigate its role in fertilization, we studied some biochemical prope ... | 1986 | 3825680 |
| quantitative analysis of lymphocyte migration from the thymus to periphery in the mexican axolotl. | 1986 | 3817254 | |
| axolotl retina and lens development: mutual tissue stimulation and autonomous failure in the eyeless mutant retina. | during eye development in the axolotl (ambystoma mexicanum shaw), morphogenetic movements bring together tissues from head epidermis, neuroectoderm and neural crest. the stages 0 to 14 of axolotl eye development were expanded from rabl's (1898) stages 1 to 10 and correlated with harrison's (1969) stages. at the onset of neurulation (stage 13 of harrison), the head epidermis is already determined to form skin, and the neuroectoderm is committed to form brain, because these tissues develop autonom ... | 1986 | 3805980 |
| role of bilateral zones of ingressing superficial cells during gastrulation of ambystoma mexicanum. | vital dye staining and cell lineage tracers were used to mark superficial cells of early ambystoma mexicanum gastrulae. superficial marks placed between the equator and the blastopore, on the dorsal midline, stained notochord, whereas marks or injections made at similar animal-vegetal levels but 90 degrees to either side of the dorsal midline were later found in somitic mesoderm. notochord marks remained on the dorsal surface of the archenteron throughout gastrulation, though they became elongat ... | 2013 | 3794603 |
| the pigmentary system of developing axolotls. iv. an analysis of the axanthic phenotype. | the axanthic mutant in the mexican axolotl (ambystoma mexicanum) was analysed with respect to the differentiation of pigment cells. transmission electron micrographs revealed the presence of melanophores and cells that are described as unpigmented xanthophores in axanthic skin. iridophores apparently failed to differentiate in axanthic axolotls (a pattern similar to that observed in melanoid axolotls). chromatographic analyses of skin extracts confirmed that there are no pteridines (xanthophore ... | 2013 | 3794587 |
| the migration of dermal cells during blastema formation in axolotls. | using the diploid/triploid cell marker in the axolotl (ambystoma mexicanum) we have examined the movement of cells from the dermis into the early limb blastema. cells of dermal origin begin to migrate beneath the wound epithelium at about 5 days postamputation, and by 10 days they are widely distributed across the amputation surface. by 15 days, a dense accumulation of blastema cells is present beneath the apical cap, and these cells are preferentially oriented in a circumferential direction. th ... | 1986 | 3792618 |
| pigment cell differentiation: the relationship between pterin content, allopurinol treatment, and the melanoid gene in axolotls. | the effects of allopurinol (an inhibitor of the enzyme xanthine dehydrogenase (xdh] and the melanoid gene on pigment cell differentiation in the axolotl were examined by analyzing pigment components of the xanthophore (pterins). pterin contents of skin extracts (70% ethanol) from wild type, allopurinol-treated and melanoid axolotls were determined by thin layer chromatography (tlc) and fluorometric scanning of tlc plates. heights of peaks produced were used as a quantitative measure for pterin c ... | 1986 | 3791419 |
| myelin lipids: a phylogenetic study. | the lipid composition of cns and pns myelin was studied in rat, xenopus, trout and torpedo. the main difference lay in the proportion of cerebrosides, which decreased in the sequence rat greater than xenopus greater than torpedo greater than trout. in addition torpedo cns and pns myelins were extremely rich in sulfatides. in some respects, torpedo appeared closer to tetrapods than trout. otherwise the proportion of the different lipid classes did not reveal any clear evolutionary trends. the pre ... | 1986 | 3785545 |
| the regeneration of double dorsal and double ventral limbs in the axolotl. | surgically made double dorsal and double ventral upper arms, comprising double extensor and double flexor muscles respectively, were amputated immediately following operation; both limb types regenerated. in terms of skeletal anatomy, a range of limb types was found. these included four-digit limbs of normal cartilage pattern, and hypomorphic limbs having from one to three digits. all of the double dorsal and the majority of the double ventral limbs were symmetrical in the dorsal-ventral axis. t ... | 1986 | 3760762 |
| environmental control in pigment pattern formation of the axolotl larva. | 1986 | 3749176 | |
| investigating possible mechanisms of specific nerve regeneration in the axolotl. | 1986 | 3749170 | |
| regeneration from discontinuous circumferences in axolotl limbs. | 1986 | 3749160 | |
| involvement of the cytoskeleton in early gray crescent formation in axolotl oocyte: relationships with germinal vesicle breakdown. | 1986 | 3749155 | |
| biochemical and ultrastructural studies on vitamin a induced proximalization of limb regeneration in axolotl. | 1986 | 3749115 | |
| selective innervation of transplanted limb muscles by regenerating motor axons in the axolotl. | the segmental pattern of motor innervation of hindlimb muscles in the axolotl was studied before and after reinnervation. to ascertain the specificity of reinnervation, the four spinal nerves innervating the hindlimb were severed and allowed to regenerate. the segmental origin of axons reinnervating particular muscles was then determined by intracellular recording from muscle fibers. muscles were reinnervated in a specific manner: from the outset, the axons reinnervating each muscle originated l ... | 1986 | 3746433 |
| pattern discontinuity, polarity and directional intercalation in axolotl limbs. | axolotl limb stumps with dorsal-ventral confrontations between digits 2 and 3 but with a normal anterior-posterior pattern were created by grafting between contralateral limbs. graft and host differed in ploidy to permit a determination of the origin of cells in the regenerated limb. after regeneration, limbs were analysed for skeletal and muscle patterns and for the distribution of marked cells in the regenerate. regenerated limbs showed varying degrees of abnormality in their dorsal-ventral or ... | 1986 | 3734687 |
| cellular contribution from dermis and cartilage to the regenerating limb blastema in axolotls. | using the triploid/diploid cell marker in the axolotl, ambystoma mexicanum, we have analyzed the extent to which cells derived from the dermis and the skeleton contribute to the regenerating limb blastema. we found that dermal cells contribute 43% of the blastemal cell population whereas cells derived from skeletal tissue contribute only 2%. when compared to the availability of cells at the plane of amputation, dermal cells overcontribute by greater than twofold whereas skeletal cells undercontr ... | 1986 | 3732605 |
| identification of a second type of catecholaminergic neuron in the spinal cord of the axolotl salamander. | two distinct groups of catecholaminergic neurons were observed by histofluorescence techniques in the spinal cord of the axolotl salamander, only one of which was detected in normal intact cords. these neurons were located in the ventral ependymal zone. when the spinal cord was transected, a second group of catecholaminergic neurons was observed in the lateral portions of the ventral gray matter of the spinal cord caudal to the transection site. these observations suggest that the amount of cate ... | 1986 | 3732481 |
| the pigmentary system of developing axolotls. iii. an analysis of the albino phenotype. | the albino mutant in the mexican axolotl (ambystoma mexicanum) is analysed with respect to the differentiation of pigment cells. pigment cells were observed with the transmission electron microscope in order to determine any unusual structural characteristics and to determine what happens to each of the cell types as development proceeds. chemical analyses of pteridine pigments were also carried out, and the pattern of pteridines in albino animals was found to be more complex than, and quantitat ... | 1986 | 3723064 |
| changes in patterns of protein synthesis in axolotl oocytes during progesterone-induced maturation. | patterns of protein phosphorylation and synthesis during axolotl (ambystoma mexicanum) oocyte maturation were studied by incorporation of [32p]orthophosphate and [35s]methionine into polypeptides, followed by two-dimensional gel electrophoresis. various alterations were observed after progesterone treatment: de novo appearance of [35s]methionine-labelled polypeptides, a quantitative increase in previously synthesized proteins and a quantitative decrease in or disappearance of other previously sy ... | 2013 | 3723056 |
| behavioral development in the absence of neural activity: effects of chronic immobilization on amphibian embryos. | embryos of xenopus laevis and ambystoma mexicanum were continually immobilized from premotile stages of development to stages at which normally reared embryos were swimming well. immobilization was achieved through exposure to solutions of chloretone, lidocaine, or alpha-bungarotoxin. at a number of stages after recovery from the drugs, spontaneous and stimulated behaviors were extensively quantified. immobilization of ambystoma embryos resulted in temporary defects in musculoskeletal developmen ... | 1986 | 3711983 |
| comparison of the effects of vitamin a on limb development and regeneration in the axolotl, ambystoma mexicanum. | the objective of this investigation was to compare the effect of vitamin a on limb development and limb regeneration in the same animal, at the same time, thus eliminating the possibility that species differences or different rates of uptake between animals would influence the results. axolotl larvae had both right limbs amputated and then were treated with retinol palmitate by immersion at 60 or 300 mg l-1 for 4 or 10 days. intact left developing limbs at the cone, two-digit, or four-digit stag ... | 2013 | 3711785 |
| the precision of pathway selection by developing peripheral axons in the axolotl. | at the time of hindlimb development in the axolotl there is a well-established but still developing trunk innervation. the trunk innervation is primarily composed of the segmental nerves, each of which consists of a dorsal and a ventral ramus and its branches. at a few segmental levels in the region of the hindlimb a large number of additional axons arise to innervate the limb. to reach the limb, they must grow via the ventral rather than the dorsal rami. the precision with which this pathway is ... | 1986 | 3711780 |
| calcium-independent stimulation of glycogenolysis by arginine vasotocin and catecholamines in liver of the axolotl (ambystoma mexicanum) in vitro. | arginine vasotocin (avt) caused a concentration-dependent increase of glycogen phosphorylase alpha activity, breakdown of glycogen and release of glucose, when added to pieces of axolotl liver in organ culture. the concentration causing half-maximal response (ec50) was about 1 nmol/l. these actions of avt were unaffected by the adrenergic antagonists propranolol, yohimbine and prazosin, but were blocked by equimolar amounts of d(ch2)5tyr(me)avt, a synthetic antagonist of vasopressin. arginine va ... | 1986 | 3701246 |
| [recovery of acetylcholinesterase activity in the axolotl embryo following inhibition with the organophosphorus inhibitor gd-7]. | the restoration of acetylcholinesterase (ache) activity in axolotl ambystoma mexicanum embryo after treatment at 38-42 stages with irreversibly ache-inhibiting gd-7 phosphororganic inhibitor in concentrations, significantly decreasing ache activity level, but not interfering with ontogenesis has been studied. the rate of ache activity restoration in gd-7 treated axolotl embryo depends on the level of the enzyme restraint and the stage of the embryo development. the value of maximal restoration o ... | 2006 | 3696676 |
| reformation of the pattern of neuromuscular connections in the regenerated axolotl hindlimb. | retrograde neuronal tracing with horseradish peroxidase (hrp) was used to determine the position in the spinal cord of motor neurone pools innervating muscles in the regenerated axolotl hindlimb. this method allows a detailed analysis of the accuracy of reformation of neuromuscular connections. the results show that regenerated distal limb muscles are reinnervated by motor neurones in the same region of the cord as those that innervate normal control distal limb muscles but that proximal muscles ... | 1987 | 3652997 |
| dorsal root ganglia grafts stimulate regeneration of denervated urodele forelimbs: timing of graft implantation with respect to denervation. | amphibian forelimb regeneration is a nerve-dependent process; nerves presumably release one or more neurotrophic factors that stimulate blastema cell division. to date several candidate molecules/factors have been shown to stimulate macromolecular synthesis and/or mitosis but sustained cell cycle activity and blastema development have not been achieved. because dorsal root ganglia (drg) implants are capable of promoting regeneration of denervated adult newt limbs (kamrin & singer, 1959), we have ... | 1987 | 3652994 |
| the pattern of innervation in serially duplicated axolotl limbs: further evidence for the existence of local pathway cues? | the innervation of the biceps muscle was examined in regenerated and vitamin a-induced serially duplicated axolotl forelimbs using retrograde transport of horseradish peroxidase. the regenerated biceps muscle becomes innervated by motor neurones in the same position in the spinal cord as the normal biceps motor pool. in previous experiments in which the innervation of a second copy of a proximal limb muscle was examined in serially duplicated limbs (stephens, holder & maden, 1985), the duplicate ... | 2012 | 3652982 |
| dna-ligase activity in axolotl early development: evidence for a multilevel regulation of gene expression. | 1986 | 3625120 | |
| selective reinnervation of transplanted muscles by their original motoneurons in the axolotl. | the motoneurons innervating 3 hindlimb extensor muscles, anterior and posterior iliotibialis and iliofibularis, were studied separately by retrograde labeling with hrp. the motor pools for these 3 muscles overlapped to such an extent that individual motoneurons between ventral roots 16 and 17 could not be assigned unambiguously to one pool or another. thus, conventional retrograde labeling could not identify particular axolotl motoneurons. instead, a double retrograde-labeling technique was empl ... | 1987 | 3598652 |
| the surfactant system of the lung in the mexican axolotl ambystoma mexicanum. | the broncho-alveolar space of axolotl contains numerous osmiophilic structures, which have been classified morphologically into 3 types of inclusions. type i inclusions exhibited lattices of square to rectangular grid patterns with membranous elements 6 nm thick. this lattice was crossed by a 2 nm dense line. type ii inclusions were composed of 7 nm dark lines and 15.5 nm light lines in an alternating repeating pattern. furthermore, the light lines showed an intrapenoid line of 2 nm. type iii in ... | 1987 | 3581181 |
| the eyeless mutant mexican salamander (ambystoma mexicanum): evidence for an imbalanced anteroposterior morphogenetic system. | prospective anterolateral neural fold was grafted from normal axolotls into the posterior neural fold region (statocyst area) of eyeless mutant hosts. these unilateral anteroposterior grafts stimulated bilateral eye formation in the eyeless mutant at a rate of 79%. replacing the statocyst area of mutants with the statocyst area from normals stimulated bilateral eye formation in 49% of the cases. grafting of prospective anterolateral neural fold between normals and mutants or excising the statocy ... | 1987 | 3559793 |
| regeneration from half lower arms in the axolotl. | a technique involving grafting of pieces of skin from the head onto the limb in order to isolate halves of the limb is described. this technique was used to isolate posterior, anterior, dorsal and ventral halves of the lower arm. all halves produced regenerates but no part of the limb was able to produce a high proportion of regenerates with a complete pattern of skeletal structures. posterior half stumps regenerated limbs with a mean digit number of 2.7 and had a normal dorsoventral muscle patt ... | 2012 | 3540176 |
| effects of exogenous guanosine on chromatophore differentiation in the axolotl. | guanosine is shown to dramatically alter the pigment phenotype of axolotls by suppressing melanization and enhancing the biosynthesis and deposition of purine-derived pigments. phenotypic changes caused by guanosine are manifested by altered chromatophore differentiation patterns such that few black pigment cells (melanophores) differentiate (and those that do are punctate and necrotic in appearance), whereas the development of yellow (xanthophore) and reflecting (iridophore) pigment cells is en ... | 1987 | 3507661 |
| is gaba an afferent transmitter in the vestibular system? | this study was undertaken to determine the possible role of gaba as an afferent transmitter in the vestibular system of the axolotl. we studied the effects of gaba, muscimol, bicuculline and picrotoxin on the spontaneous spike discharge of the afferent fibers of the sacculi lagena and anterior semicircular canal. it was found that gaba and muscimol produce a very weak excitatory effect which does not mimic either the temporal course or the amplitude of the response of vestibular afferents to phy ... | 1987 | 3497911 |
| the role of cartilage and fibronectin during respecification of pattern induced in the regenerating amphibian limb by retinoic acid. | when retinoic acid (ra) is applied to the regenerating limb the positional information of blastemal cells is respecified and extra limb segments develop. we are trying to elucidate the molecular basis of the action of ra and report here experiments focused on the role that fibronectin (fn) might play in the process. the fn distribution in stump tissues, regeneration blastemas and ra-treated blastemas was investigated by immunocytochemistry. two effects of ra were observed. firstly, excessive ded ... | 1987 | 3449397 |
| fine structure of taste buds in the tongue, palatal mucosa and gill arch of the axolotl, ambystoma mexicanum. | 1987 | 3431793 | |
| anatomy of axolotl flank integument during limb bud development with special reference to a transcutaneous current predicting limb formation. | we have compared the anatomy of immature axolotl integument from limb-forming regions with adjacent non-limb-forming regions of the flank, concentrating on the earliest stages of limb bud development. we have extended these observations to include prominent buds just prior to their differentiation. at the ultrastructural level, we note striking differences between these two regions of skin, including a complete loss of hemidesmosomes and tonofilaments in the basal cells of the epidermis; a marke ... | 1987 | 3430119 |
| a test of the punctuated-cycling hypothesis in ambystoma forelimb regenerates: the roles of animal size, limb innervation, and the aneurogenic condition. | the punctuated-cycling (pc) hypothesis [39] predicts that the proportion of actively cycling (ac) cells within the blastema influences the rate of limb regeneration in urodele amphibians. to test this, we compared the rate of regeneration and the parameters of the pc hypothesis in small and large ambystoma mexicanum larvae and in aneurogenic limbs of ambystoma maculatum. aneurogenic limbs regenerated more slowly than limbs of small axolotls, but considerably faster than limbs of large axolotls. ... | 1987 | 3428513 |
| differentiation of cartilage from cranial neural crest in the axolotl (ambystoma mexicanum). | explants of cranial neural crest from neurula-stage ambystoma mexicanum embryos form cartilage nodules in 10-14 days, when cultured with pharyngeal endoderm. the time course of formation of the nodules, and their appearance, correspond closely to that observed for visceral cartilage in vivo. endoderm from any area of the sheet surrounding the pharyngeal cavity can induce cartilage formation, but endoderm from regions posterior to the pharyngeal cavity cannot. no other tissues are required for in ... | 1987 | 3428510 |
| changes in brain gangliosides of the neotene and metamorphic (thyroxine-induced) newt axolotl (ambystoma mexicanum). | qualitative and quantitative changes in the concentration of proteins, sialoglycoproteins and gangliosides and in the composition of gangliosides in the brains of the neotene and the thyroxine-induced metamorphic newt axolotl (ambystoma mexicanum) were investigated. during metamorphosis two polar gangliosides (gt1b and gq1b) decreased by about 5% each. on the contrary gd1a increased to 10%. another developmental trend was a slight increase of two other disialogangliosides (gd1b, gd2). additional ... | 1987 | 3428191 |
| ir-met and ir-leu enkephalin content in the axolotl brain (ambystoma mexicanum). | the peptides met- and leu-enkephalin were identified in the telencephalon, rombencephalon, diencephalon and hypophysis of ambystoma mexicanum brain by radioimmunoassay procedure. the met-enkephalin was the predominant peptide present in the axolotl brain in contrast with leu-enkephalin, except in the hypophysis where the ratio met/leu was 2.2/l. the clear differences in the concentration between enkephalins through a submammalian brain species as ambystoma genus and the possibility that leu-enke ... | 1988 | 3419559 |
| change in the level of free amino acids in the regenerating limb of ambystoma mexicanum. | 1988 | 3412355 | |
| effects of forelimb amputation on protein synthesis in spinal cord of the axolotl. | 1988 | 3412354 | |
| intercalary limb regeneration after auto- and xenoplastic grafting of mature autopodia at the stylopodial stump in larval salamandra salamandra and ambystoma mexicanum. | 1988 | 3412343 | |
| control of blastema cell proliferation during axolotl limb regeneration: in vitro cell culture study. | 2012 | 3412334 | |
| regenerating afferent fibers stimulate the recovery of mauthner cell dendritic branching in the axolotl. | in the medulla of the axolotl (ambystoma mexicanum), mauthner cells (m-cells) occur as a pair of large identifiable neurons at the level of entry of the vestibular nerve (nviii). each receives synapses from the ipsilateral nviii; the terminals can be identified as club endings and are restricted to a specific set of m-cell dendritic branches. we have examined these branches for morphologic changes following long-term deafferentation in the presence and absence of nerve regeneration. deafferentat ... | 1988 | 3411367 |
| regeneration of descending axons in the spinal cord of the axolotl. | horseradish peroxidase was used to describe the positions and approximate numbers of neurones with axons that descend to the lumbar spinal cord in normal axolotls and axolotls whose spinal cord had been transected 3-23 months previously. three to 4 months after the transection approximately 10% of the axons had grown across the cut and returned to the lumbar spinal cord whereas 23 months after the transection the number and distribution of these cells were approaching those of the controls. | 1988 | 3399135 |
| blastema cell proliferation in vitro: effects of limb amputation on the mitogenic activity of spinal cord extracts. | primary cultures of mesenchymal cells of axolotl limb blastemas provide a very sensitive in vitro bioassay for studying nerve dependence of newt regeneration. these cells can be stimulated by crude spinal cord extracts of non-amputated animals in a dose-dependent manner up to 60 micrograms protein/ml of culture medium; at this concentration the mitotic index is increased 4-fold. spinal cord extracts of axolotls 14 days after forelimb amputation (i.e., late bud stage) are more efficient in stimul ... | 1988 | 3390627 |
| local embryonic matrices determine region-specific phenotypes in neural crest cells. | membrane microcarriers were used to determine the ability of regional extracellular matrices to direct neural crest cell differentiation in culture. neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing and by differentiating into pigment cells. in contrast, matrix material from the presumptive site of dorsal root ganglia stimulated pronounced cell-cell association and neurotypic expression. cell line ... | 2012 | 3388022 |