Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| high production system of the antibacterial peptide plg-1. | propionibacterium thoenii p-127 produces and releases to the growth medium antibacterial agents that can be used as natural preservatives. the concentrations of these antibacterial agents in the growth medium are very low, and their activity can be detected only in concentrated medium, even in a bioreactor. a simple and efficient system to produce propionicin plg-1 without the use of a bioreactor was investigated. fermentation in screw-cap bottles without shaking produced antibacterial activity ... | 2003 | 12675584 |
| antibiotic-resistant acne: lessons from europe. | propionibacterium acnes and p. granulosum are widely regarded as the aetiological agents of inflammatory acne. their proliferation and metabolism are controlled using lengthy courses of oral and/or topical antibiotics. despite numerous reports of skin colonization by antibiotic-resistant propionibacteria among acne patients, accurate prevalence data are available only for the u.k. | 2003 | 12653738 |
| purified human mdr 1 modulates membrane potential in reconstituted proteoliposomes. | human multidrug resistance (hu mdr 1) cdna was fused to a p. shermanii transcarboxylase biotin acceptor domain (tcbd), and the fusion protein was heterologously overexpressed at high yield in k(+)-uptake deficient saccharomyces cerevisiae yeast strain 9.3, purified by avidin-biotin chromatography, and reconstituted into proteoliposomes (pls) formed with escherichia coli lipid. as measured by ph- dependent atpase activity, purified, reconstituted, biotinylated mdr-tcbd protein is fully functional ... | 2003 | 12653559 |
| an in vitro model for investigating intestinal adhesion of potential dairy propionibacteria probiotic strains using cell line c2bbe1. | the purposes of this study were to screen the adhesion properties of dairy propionibacteria strains and evaluate whether c2bbe1 could be used in the screening of potential probiotic strains. | 2003 | 12641713 |
| anti-acne effects of oriental herb extracts: a novel screening method to select anti-acne agents. | the acne-therapeutic effects of oriental herb extracts were investigated in terms of antichemotactic effect on polymorphonuclear leucocytes, antilipogenic actions, antibacterial activity against propionibacterium acnes and resistance induction potency in the bacteria. the ethanol extract (0.01%) of angelica dahurica markedly suppressed neutrophil chemotaxis, comparable to the effect of erythromycin (0.01%), whereas a strong antilipogenic effect was obtained with rhizoma coptidis (coptis chinensi ... | 2003 | 12637783 |
| kinetics of adsorption and desorption of aflatoxin b1 by viable and nonviable bacteria. | the reactions involved in the binding (adsorption) and release (desorption) of aflatoxin b1 (afb1) to and from the surface of bacteria were investigated. viable and heat-killed lactobacillus rhamnosus gg, l. rhamnosus lc-705, and propionibacterium freudenreichii subsp. shermanii js were incubated in phosphate-buffered saline containing variable concentrations (0.0017 to 13.3 microg/ml) of afb1. the relationship between the bacterial surface hydrophobicity and the afb1 adsorption affinity was als ... | 2003 | 12636295 |
| inhibition of propionibacterium acnes-induced mediators of inflammation by indian herbs. | propionibacterium acnes, an anaerobic pathogen, plays an important role in the pathogenesis of acne by inducing certain inflammatory mediators. these mediators include reactive oxygen species (ros) and pro-inflammatory cytokines. in the present study, ros, interleukin-8 (il-8) and tumor necrosis factor-alpha (tnf-alpha) were used as the major criteria for the evaluation of anti-inflammatory activity. to prove the anti-inflammatory effects of herbs, polymorphonuclear leukocytes (pmnl) and monocyt ... | 2003 | 12622461 |
| vitreous and aqueous penetration of orally administered gatifloxacin in humans. | to investigate the penetration of gatifloxacin, a novel extended-spectrum fourth-generation fluoroquinolone antibiotic, into the vitreous and aqueous humor after oral administration. | 2003 | 12617704 |
| [treatment of mild to moderate acne]. | 2003 | 12605143 | |
| [what's new concerning the pathophysiology of acne?]. | 2003 | 12605138 | |
| aim inhibits apoptosis of t cells and nkt cells in corynebacterium-induced granuloma formation in mice. | apoptosis inhibitor expressed by macrophages (aim) inhibits apoptosis of cd4(+)cd8(+) (cd4/cd8) double-positive thymocytes, and supports the viability of these cells on the thymic selection. however, pleiotropic functions of aim have been suggested. in this study, heat-killed corynebacterium parvum (c. parvum) was injected into mice carrying the homozygous mutation (aim(-/-)) and wild-type (aim(+/+)) mice, to investigate the role of aim in the formation of hepatic granulomas. in aim(-/-) mice, t ... | 2003 | 12598318 |
| the role of innate immunity in the pathogenesis of acne. | acne is a multifactorial disease of the pilosebaceous follicle. the most significant pathogenetic factors of acne are: abnormal ductal keratinization, increased sebum secretion, abnormalities of the microbial flora and inflammation. the pilosebaceous unit is an immunocompetent organ. keratinocytes and sebocytes may act as immune cells capable of pathogen recognition and abnormal lipid presentation, and they might have an important role in initiating and perpetuating the activation of both innate ... | 2003 | 12592074 |
| eradication of propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. | propionibacterium acnes is a gram-positive, microaerophilic bacterium that causes skin wounds. it is known to naturally produce high amounts of intracellular porphyrins. the results of the present study confirm that the investigated strain of p. acnes is capable of producing endogenic porphyrins with no need for any trigger molecules. extracts from growing cultures have demonstrated emission peaks around 612 nm when excited at 405 nm, which are characteristic for porphyrins. endogenic porphyrins ... | 2003 | 12589953 |
| propionibacterial biofilms cannot explain antibiotic resistance but might contribute to some cases of antibiotic recalcitrant acne. | 2003 | 12588400 | |
| antibiotic-resistant propionibacteria acnes may not be the major issue clinically or microbiologically in acne. | 2003 | 12588399 | |
| a microbiological approach to acne vulgaris. | the present article gives a concise survey of contemporary opinions on acne vulgaris, its etiopathogenesis, clinical forms and laboratory diagnostics. in particular, the value of microbiological diagnostics and possibilities of local as well as general therapy are discussed. moreover, our experience is described with vaccinotherapy to manage serious clinical forms and cases when current therapy fails. | 2002 | 12572891 |
| identification, isolation and quantification of representative bacteria from fermented cassava dough using an integrated approach of culture-dependent and culture-independent methods. | the use of denaturing gradient gel electrophoresis (dgge) and traditional culture-depending methods for examining the bacterial community of traditional cassava starch fermentation were investigated. it appeared that dgge profiles of total dna of cassava dough exhibited 10 distinguishable bands. in contrast, dgge fingerprints of bacteria recovered from enrichment cultures of fermented dough gave variable profiles containing fewer bands. bands corresponding to five bacterial species detected by d ... | 2003 | 12568751 |
| propionibacterium acnes resistance: a worldwide problem. | antibiotic therapy directed against propionibacterium acnes has been a mainstay of treatment for more than 40 years. despite years of widespread use of systemic tetracyclines and erythromycin, change in p. acnes sensitivity to antibiotics was not seen until the early 1980s. the first clinically relevant changes in p. acnes antibiotic sensitivity were found in the usa shortly after the introduction of topical formulations of erythromycin and clindamycin. by the late 1980s, p. acnes strains with v ... | 2003 | 12566805 |
| new aspects in acne inflammation. | there is ample clinical evidence suggesting that the nervous system such as emotional stress can influence the course of acne. we examined possible participation of cutaneous neurogenic factors including neuropeptides, neuropeptide-degrading enzymes and neurotrophic factors, in association with inflammation in the pathogenesis of acne. immunohistochemical studies revealed that substance p (sp)-immunoreactive nerve fibers were in close apposition to the sebaceous glands, and that neutral endopept ... | 2003 | 12566801 |
| the rationale for using a topical retinoid for inflammatory acne. | both comedogenesis and the development of inflammatory lesions in acne vulgaris appear to be related to genetic as well as immune processes. the key regulatory cytokine, interleukin-1alpha, has recently been documented as playing a major role in both the hypercornification and the orchestration of immune factors, ultimately resulting in noninflammatory and inflammatory lesions. topical retinoids, such as tretinoin, and topical retinoid analogs, such as adapalene and tazarotene, help normalize th ... | 2003 | 12553848 |
| bacterial contamination in postmortem bone donors. | we analyzed factors influencing the contamination rate of allografts and blood samples obtained from postmortem bone donors. 5,710 allografts were harvested, from 550 donors of which 3,164 (55%) were swab culture negative. blood cultures were positive in 140 donors (26%). the risk of graft contamination increased with each extra team member (odds ratio 1.9). it was also higher with organisms of greater virulence in donors with a positive blood culture (or 3.5). the risk of blood contamination in ... | 2002 | 12553518 |
| anti-inflammatory effects of erythromycin and tetracycline on propionibacterium acnes induced production of chemotactic factors and reactive oxygen species by human neutrophils. | propionibacterium acnes (p. acnes), an anaerobic pathogen, plays an important role in the pathogenesis of acne and seems to initiate the inflammatory process by producing neutrophil chemotactic factors (ncf). once neutrophils attracted by bacterial chemoattractants reach the inflamed site, they release inflammatory mediators such as lysosomal enzymes and reactive oxygen species (ros). previously, it has been shown that antibiotics may affect acne by means other than their anti-bacterial effects. ... | 2002 | 12546757 |
| vitreous penetration of orally administered gatifloxacin in humans. | to investigate the penetration of gatifloxacin, a novel extended-spectrum fluoroquinolone antibiotic, into the vitreous humor after oral administration. | 2002 | 12545689 |
| efficient mechanical disruption of lactobacillus helveticus, lactococcus lactis and propionibacterium freudenreichii by a new high-pressure homogenizer and recovery of intracellular aminotransferase activity. | microbiological studies often involve bacterial cell fractionation, which is known to be difficult for gram-positive as compared to gram-negative bacteria. our purpose was to test the breaking efficiency of a new high-pressure pilot homogenizer for three gram-positive species involved in dairy technology and to assess the activity of an intracellular aminotransferase. varied pressures (50, 100 and 200 mpa) were applied to concentrated bacterial suspensions (1.2 mg dry weight/ml) of lactobacillus ... | 2003 | 12545379 |
| enhancement of endotoxin activity by muramyldipeptide. | synthetic muramyldipeptide (mdp), the minimum structural moiety of bacterial peptidoglycan for adjuvant and related activities, sensitized mice for two types of lethal shock induced by lipopolysaccharide (lps): an early anaphylactoid shock and late endotoxin shock. in relation to the late reaction in mdp-primed mice, enhanced production of inflammatory cytokines was induced in response to various bacterial components. mdp showed a priming effect in mice not only when administered parentally but ... | 2002 | 12537692 |
| glucose fermentation by propionibacterium microaerophilum: effect of ph on metabolism and bioenergetic. | ph affected significantly the growth and the glucose fermentation pattern of propionibacterium microaerophilum. in neutral conditions (ph 6.5-7.5), growth and glucose fermentation rate (qs) were optimum producing propionate, acetate, co(2), and formate [which together represented 90% (wt/wt) of the end products], and lactate representing only 10% (wt/wt) of the end products. in acidic conditions, propionate, acetate, and co(2) represented nearly 100% (wt/wt) of the fermentation end products, whe ... | 2003 | 12520370 |
| propionimicrobium gen. nov., a new genus to accommodate propionibacterium lymphophilum (torrey 1916) johnson and cummins 1972, 1057al as propionimicrobium lymphophilum comb. nov. | based upon significant differences in chemotaxonomic properties, i.e., amino acid composition of peptidoglycan, fatty acids and base composition of dna, and supported by the phylogenetic position of the 165 rdna sequence the species propionibacterium lymphophilum was reclassified as propionimicrobium lymphophilum comb. nov. | 2002 | 12508849 |
| in vitro activities of daptomycin, vancomycin, quinupristin- dalfopristin, linezolid, and five other antimicrobials against 307 gram-positive anaerobic and 31 corynebacterium clinical isolates. | the activities of daptomycin, a cyclic lipopeptide, and eight other agents were determined against 338 strains of gram-positive anaerobic bacteria and corynebacteria by the nccls reference agar dilution method with supplemented brucella agar for the anaerobes and mueller-hinton agar for the corynebacteria. the daptomycin mics determined on ca(2+)-supplemented (50 mg/liter) brucella agar plates were one- to fourfold lower than those determined in unsupplemented media. daptomycin was highly active ... | 2003 | 12499210 |
| microbial contamination of the anterior chamber during phacoemulsification. | to study the nature and frequency of anterior chamber contamination during phacoemulsification. | 2002 | 12498855 |
| [amyloidosis associated with chronic granulomatous disease in a patient with a renal transplant and recurrent urinary tract infections]. | chronic granulomatous disease is a group of syndromes which share a defect in a component of the phagocyte nadph-oxidase complex. without this enzyme activity, phagocytic cells cannot produce superoxide, peroxide, and other potent microbicidal radicals, and are less able to kill ingested pathogens. the clinical picture is characterised by recurrent life-threatening bacterial and fungal infections and abnormal tissue granuloma formation. on the other hand, amyloidosis is a systemic disease with r ... | 2002 | 12497752 |
| in vitro bactericidal effect of low-dose ultraviolet b in patients with acne. | 2002 | 12482057 | |
| robust evidence is needed in treating acne. | 2002 | 12480866 | |
| cell-adhered conjugated linoleic acid regulates isomerization of linoleic acid by resting cells of propionibacterium freudenreichii. | the microbiological isomerization of linoleic acid (la) to conjugated linoleic acid (cla) was studied in resting cell suspensions of a propionibacterium and micellar la to identify factors critical in the isomerization efficiency. these suspensions, containing cells 5x10(10) colony-forming units ml(-1) and 510 micro g la ml(-1), isomerized about 90% of la to cla. however, the yield was not improved with higher amounts of micellar la, suggesting that the cells had a fixed capacity to carry out th ... | 2002 | 12466891 |
| glucose metabolism of lactic acid bacteria changed by quinone-mediated extracellular electron transfer. | it can be expected that extracellular electron transfer to regenerate nad+ changes the glucose metabolism of the homofermentative lactic acid bacteria. in this work, the glucose metabolism of lactobacillusplantarum and lactococcus lactis was examined in resting cells with 2-amino-3-carboxy-1,4-naphthoquinone (acnq) as the electron transfer mediator and ferricyanide (fe(cn)6(3-)) as the extracellular electron acceptor. nadh in the cells was oxidized by acnq with the aid of diaphorase, and the red ... | 2002 | 12450120 |
| sensitivity and rapidity of blood culture bottles in the detection of cornea organ culture media contamination by bacteria and fungi. | to test the bactericidal activity of standard organ culture medium, and to compare the sensitivity and rapidity of blood culture bottles with conventional microbiological methods for detection of bacteria and fungi inoculated in a standard cornea organ culture medium. | 2002 | 12446379 |
| in situ localization of propionibacterium acnes dna in lymph nodes from sarcoidosis patients by signal amplification with catalysed reporter deposition. | sarcoidosis is a systemic granulomatous disease of unknown aetiology. many genomes of propionibacterium acnes and p. granulosum have been detected in lymph nodes from patients with sarcoidosis. in situ localization of propionibacterial genomes in sarcoid lymph nodes may help to establish an aetiological link between sarcoidosis and these indigenous bacteria. formalin-fixed and paraffin-embedded biopsy samples of lymph nodes from nine patients with sarcoidosis, nine patients with tuberculosis, an ... | 2002 | 12434425 |
| novel bacterial polar lipids containing ether-linked alkyl chains, the structures and biological properties of the four major glycolipids from propionibacterium propionicum pcm 2431 (atcc 14157t). | propionibacterium propionicum belongs to the "acnes group" of propionibacteria, which is currently considered as clinically important because of its growing potential in infections, in particular with those connected with immune system dysfunctions. propionibacteria are thought to be actinomycete-like microorganisms and may still cause diagnostic difficulties. the chloroform-methanol extracts of the cell mass of p. propionicum (type strain) gave in tlc analysis the characteristic glycolipid prof ... | 2003 | 12427753 |
| use of predictive modeling for propionibacterium strain classification. | computed data analysis of biochemical or molecular profiles is currently used in studies of microbial taxonomy, epidemiology, and microbial diversity. we assessed the use of partial least squares (pls) regression for multivariate data analysis in bacteriology. we identified clear relationships between rapd profiles of propionibacteria strains and their species classification, autolytic capacities, and their origins. the pls regression also predicted species identity of some strains with rapd pro ... | 2002 | 12421076 |
| gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cdna microarray system. | fulminant hepatic failure (fhf) is a disease characterized by sudden and severe impairment of liver function. to elucidate the mechanism involved in fhf, we adopted a murine model of fhf by administrating mice with heat-killed propionibacterium acnes (p. acnes), followed by a low dose of lipopolysaccharide (lps), and analyzed the dynamic change of gene expression profile of the murine liver using an in-house cdna microarray system which contained most of the cdnas encoding chemokines/cytokines a ... | 2002 | 12419307 |
| acne phototherapy with a high-intensity, enhanced, narrow-band, blue light source: an open study and in vitro investigation. | the purpose of this study was to investigate the efficacy of phototherapy with a newly-developed high-intensity, enhanced, narrow-band, blue light source in patients with mild to moderate acne. an open study was performed in acne patients who were treated twice a week up to 5 weeks. acne lesions were reduced by 64%. two patients experienced dryness. no patient discontinued treatment due to adverse effects. in vitro investigation revealed that irradiation from this light source reduced the number ... | 2002 | 12413768 |
| ocular surface inflammation induced by propionibacterium acnes. | in the eye, is commonly isolated in the lid, conjunctiva, and meibomian gland secretion. well known as a causative bacterium of granulomatous endophthalmitis and a potent inflammatory stimulus, reportedly induces a delayed-type hypersensitivity (dth) response and forms granulomas in the liver and lung in animal models. in this study, we examined whether can induce a dth response in the cornea. | 2002 | 12410043 |
| inhibition of lipase activity in antibiotic-resistant propionibacterium acnes strains. | erythromycin-sensitive and/or clindamycin-sensitive strains of propionibacterium acnes show a reduced lipase production at levels below the minimal growth-inhibitory concentration (mic). the objective of this study was to determine whether erythromycin and clindamycin concentrations far below the mic inhibit lipase production in p. acnes strains resistant to these antibiotics. | 2002 | 12399674 |
| genetic diversity in swiss cheese starter cultures assessed by pulsed field gel electrophoresis and arbitrarily primed pcr. | to assess intraspecific genetic heterogeneity among commercial swiss cheese starter culture strains of lactobacillus helveticus, streptococcus thermophilus and propionibacterium freudenreichii and to compare the efficacy of two genetic typing methods. | 2002 | 12390494 |
| evaluation of the 3d bact/alert automated culture system for the detection of microbial contamination of platelet concentrates. | bacterial transmission remains the major component of morbidity and mortality associated with transfusion-transmitted infections. platelet concentrates are the most common cause of bacterial transmission. the bact/alert 3d automated blood culture system has the potential to screen platelet concentrates for the presence of bacteria. evaluation of this system was performed by spiking day 2 apheresis platelet units with individual bacterial isolates at final concentrations of 10 and 100 colony-form ... | 2002 | 12383336 |
| [infectious endocarditis due to propionibacterium acnes on a mechanical heart valve and cardiac stimulator electrode]. | 2002 | 12378976 | |
| influence of short-chain fatty acids on iron absorption by proximal colon. | short-chain fatty acids produced by bacterial fermentation in the colon enhance the local absorption of cations, such as calcium, that could be used to improve the bioavailability of iron if a significant colonic absorption of iron were to occur. | 2002 | 12374223 |
| endocarditis due to anaerobic bacteria. | this review describes the microbiology, diagnosis and management of endocarditis due to anaerobic bacteria. anaerobic bacteria are an uncommon but important cause of endocarditis. most cases of anaerobic endocarditis are caused by anaerobic cocci, propionibacterium acnes and bacteroides fragilis group. predisposing factors and signs and symptoms of endocarditis caused by anaerobic bacteria are similar to those seen in endocarditis with facultative anaerobic bacteria with the following exceptions ... | 2002 | 12373039 |
| a randomized, double-blind, multicenter, parallel group study to compare relative efficacies of the topical gels 3% erythromycin/5% benzoyl peroxide and 0.025% tretinoin/erythromycin 4% in the treatment of moderate acne vulgaris of the face. | combination treatments for acne vulgaris, such as benzamycin (3% erythromycin/5% benzoyl peroxide) and stievamycin (0.025% tretinoin/erythromycin 4%), reduce bacterial growth, which contributes to the inflammatory lesions typical of adolescent acne, and also decrease the epidermal cell compaction which may form the characteristic noninflammatory comedone. both agents contain erythromycin to reduce the growth of propionibacterium acnes in skin. benzoyl peroxide has antibiotic activity as well as ... | 2003 | 12362264 |
| [a case of sapho syndrome with paraplegia due to a thoracic kyphosis]. | a 63-year-old man visited our hospital in january 1993 because of back pain, which had been present for a year and persisted. the patient was diagnosed compression fracture of thoracic spine by another hospital. thoracic plain radiographs revealed destructive and sclerotic changes with reduction of height of t 8, t 9 vertebral body. he had kyphosis on this level. radiographs of the chest revealed hyperostosis of bilateral proximal clavicle. we diagnosed sapho syndrome (synovitis, acne, pustlosis ... | 2002 | 12355864 |
| analysis of the antimalarial drug resistance protein pfcrt expressed in yeast. | mutations in the novel membrane protein pfcrt were recently found to be essential for chloroquine resistance (cqr) in plasmodium falciparum, the parasite responsible for most lethal human malaria (fidock, d. a., nomura, t., talley, a. k., cooper, r. a., dzekunov, s. m., ferdig, m. t., ursos, l. m., sidhu, a. b., naude, b., deitsch, k. w., su, x. z., wootton, j. c., roepe, p. d., and wellems, t. e. (2000) mol. cell 6, 861-871). pfcrt is localized to the digestive vacuolar membrane of the intraery ... | 2002 | 12351620 |
| [ability of some strains of propionic acid bacteria, isolated in uzbekistan, to synthesize vitamin b12]. | 2002 | 12244731 | |
| internal controls for normalizing dna arrays. | 2002 | 12238758 | |
| [epithelioid cell granuloma in sarcoidosis: light and electron microscopic morphology]. | light and electron microscopic features of epithelioid cell granuloma in sarcoidosis were presented, focusing on the lymph node and the lung which are mostly involved. the distribution of granulomas is frequently conglomerated with occasionally central necrosis. hamazaki-wesenberg body in lymph node is considered to be closely associated with propionibacterium acnes. granuloma is encircled by reticulin fibers and collagen fibers within the granuloma are detected in electron microscopy. granuloma ... | 2002 | 12233064 |
| [etiology of sarcoidosis]. | the cause(s) of sarcoidosis is unknown. sarcoidosis seems to result from exposure of a genetically susceptible subject to a specific environmental antigen(s). from biopsy samples of lymph nodes from patients with sarcoidosis, propionibacterium acnes has been isolated in culture, and many genomes of p.acnes or p.granulosum have been detected by quantitative pcr. antigen-specific mitogenic responses of peripheral blood mononuclear cells were induced in sarcoidosis patients but not in healthy contr ... | 2002 | 12233062 |
| beneficial or deleterious effects of a preexisting hypersensitivity to bacterial components on the course and outcome of infection. | priming with heat-killed propionibacterium acnes enhances the sensitivity of mice to lipopolysaccharide (lps) and other biologically active bacterial components. we show that p. acnes priming has protective and deleterious effects on a subsequent serovar typhimurium infection. it may result in a complete protection or prolonged survival, or it may accelerate mortality of the infected mice, depending on the number of serovar typhimurium bacteria administered and on the degree of lps hypersensitiv ... | 2002 | 12228287 |
| comparative efficacy of clindamycin and benzoyl peroxide for in vivo suppression of propionibacterium acnes. | benzoyl peroxide and clindamycin are the two most widely prescribed topical antimicrobials in the treatment of acne. | 2002 | 12227872 |
| systemic antibiotic therapy for acne: a review. | acne is a multifactorial disease of the pilosebaceous unit in the skin. four contributing pathogenic factors need to be elucidated and include excess sebum production, follicular hyperkeratinization, colonization of the pilosebaceous unit by propionibacterium acnes, which is a gram positive anaerobic diphtheroid, and the release of inflammatory mediators into the follicle and dermis. one or more of these factors are targeted by each of the systemic therapies for this disease and its variant, inc ... | 2002 | 12223979 |
| [therapeutic strategy in delayed postoperative endophtalmitis: a report on 15 cases]. | to report the treatment strategies and visual acuity outcomes of chronic postoperative endophthalmitis. | 2002 | 12223947 |
| [doxycycline]. | doxycyclin is a semi-synthetic structural isomer of the tetracycline family. it exhibits good intra-cellular penetration, with bacteriostatic activity on many bacteria. different types or bacterial resistance are known. acquired resistance has a ribosomal or a plasmidic mechanism. resistance of propionibacterium acnes is secondary to a mutation of arnr. doxycyclin also has an anti-inflammatory activity, via numerous pathways. doxycyclin is rapidly and almost completely absorbed by the digestive ... | 2002 | 12218915 |
| the antibacterial activity of topical retinoids: the case of retinaldehyde. | retinoids such as retinoic acid (ra), retinol (rol) and retinaldehyde (ral) are currently used in many formulations and indications ranging form acne to skin aging. most if not all their pharmacological activities occur through binding to nuclear receptors with subsequent modulation of the activities of several genes. little attention has been given to the many other potential actions on the surface of the skin. | 2002 | 12218231 |
| propionibacteria fed to dairy cows: effects on energy balance, plasma metabolites and hormones, and reproduction. | to determine the effect of feeding propionibacteria on energy balance, milk yield, and composition, metabolites and hormones of early-lactating dairy cows, multiparous holstein cows were individually fed a total mixed ration from -2 to 12 wk postpartum with no addition (control, n = 10) or with an additional 17 g of propionibacteria culture daily (treated, n = 9). daily feed intake and milk production were recorded. plasma cholesterol, nonesterified fatty acids (nefa), leptin, insulin, glucose, ... | 2002 | 12201525 |
| substrate binding induces a cooperative conformational change in the 12s subunit of transcarboxylase: raman crystallographic evidence. | the 12s subunit of transcarboxylase is a 338 000 da hexamer that transfers carboxlylate from methylmalonyl-coa (mm-coa) to biotin; in turn, the biotin transfers the carboxylate to pyruvate on another subunit, the 5s. here, raman difference microscopy is used to study the binding of substrate and product, and their analogues, to single crystals of 12s. a single crystal is the medium of choice because it provides raman data of unprecedented quality. crystalline ligand-protein complexes were formed ... | 2002 | 12196011 |
| apparent antifungal activity of several lactic acid bacteria against penicillium discolor is due to acetic acid in the medium. | fifty-six dairy bacteria belonging to the genera lactococcus, lactobacillus, pediococcus, propionibacterium, streptococcus, enterococcus, leuconostoc, and brevibacterium were screened for antifungal activity against four species of fungi relevant to the cheese industry (penicillium discolor, penicillium commune, penicillium roqueforti, and aspergillus vesicolor). most of the active strains belonged to the genus lactobacillus, whereas penicillium discolor was found to be the most sensitive of the ... | 2002 | 12182485 |
| a randomized, double-blind comparison of a clindamycin phosphate/benzoyl peroxide gel formulation and a matching clindamycin gel with respect to microbiologic activity and clinical efficacy in the topical treatment of acne vulgaris. | one approach to suppressing the overgrowth of antibiotic-resistant bacteria is to develop combination products composed of active constituents with complementary but distinct mechanisms of antibacterial action. | 2002 | 12182256 |
| plasmid-borne macrolide resistance in micrococcus luteus. | a plasmid designated pmec2 which confers resistance to erythromycin, other macrolides, and lincomycin was detected in micrococcus luteus strain maw843 isolated from human skin. curing of this approximately 4.2 kb plasmid from the host organism resulted in erythromycin sensitivity of the strain. introduction of pmec2 into a different m. luteus strain conferred erythromycin resistance upon this strain. macrolide resistance in m. luteus maw843 was an inducible trait. induction occurred at subinhibi ... | 2002 | 12177341 |
| enhancement of circulating dendritic cell activity by immunomodulators (ok432 and kp-40). | the effects of biological response modifiers (brms) on the functions of two types of dendritic cells (dcs) were examined in relation to anti-tumor therapy. the two brms studied in our assay system were ok432 (a streptococcal preparation) and kp-40 (propionibacterium avidum: a heat-inactivated bacterial vaccine). recently, techniques for isolating human dcs from peripheral blood have been established, and dcs can be divided into two subsets: cd11c+ dcs (myeloid dc population) and cd11c- dcs (lymp ... | 2002 | 12174895 |
| what causes sarcoidosis? | limited but encouraging progress has been made over the last several years in our understanding of the etiology of sarcoidosis as a result of recent investments in epidemiologic, immunologic, and molecular biologic studies. a recent us multicenter study of sarcoidosis found few environmental or occupational exposures associated with a two-fold or higher risk of development of sarcoidosis, suggesting noninfectious exposures play a small, if any, role in causing systemic sarcoidosis. in contrast, ... | 2002 | 12172448 |
| effect of probiotics on constipation, fecal azoreductase activity and fecal mucin content in the elderly. | constipation is a common problem in elderly subjects, probiotics have been suggested to improve intestinal motility and reduce fecal enzyme activity. | 2002 | 12169860 |
| effects of bacterial direct-fed microbials on ruminal fermentation, blood variables, and the microbial populations of feedlot cattle. | a study was conducted to determine whether bacterial direct-fed microbials (dfm) could be used to minimize the risk of acidosis in feedlot cattle receiving high concentrate diets. six ruminally cannulated steers, previously adapted to a high concentrate diet, were used in a double 3 x 3 latin square to study the effects of dfm on feed intake, ruminal ph, and ruminal and blood characteristics. steers were provided ad libitum access to a diet containing steam-rolled barley, barley silage, and a pr ... | 2002 | 12162668 |
| assessment of mycobacterial, propionibacterial, and human herpesvirus 8 dna in tissues of greek patients with sarcoidosis. | the causes of sarcoidosis are unknown. in this study, we report the presence of mycobacterium tuberculosis complex and propionibacterium granulosum dna in a significant proportion of greek patients with sarcoidosis. human herpesvirus 8 dna was not detected in sarcoid tissues from greek patients. our findings are discussed. | 2002 | 12149380 |
| mediastinitis after cardiac surgery: improvement of bacteriological diagnosis by use of multiple tissue samples and strain typing. | the diagnosis of postsurgical mediastinitis (psm) among patients with sternal wound complication (swc) after cardiac surgery is sometimes difficult, as fever, elevated c-reactive protein levels, and chest pain can be caused by a general inflammatory reaction to the operative trauma and/or sternal dehiscence without infection. the definitions of psm usually used emphasize clinical signs and symptoms easily observed by the surgeon. the aim of the study was to investigate whether the use of standar ... | 2002 | 12149355 |
| persistence of escherichia coli o157:h7 in barley silage: effect of a bacterial inoculant. | the effect of a lactic acid producing bacterial (lab) inoculant on the elimination of escherichia coli o157:h7 from barley forage was assessed. | 2002 | 12147077 |
| evaluation of a new generation of culture bottle using an automated bacterial culture system for detecting nine common contaminating organisms found in platelet components. | an automated bacterial culture system (bact/alert 3d, biomérieux) has been previously validated with a variety of bacteria in platelets. the recovery of bacteria in platelets using a new generation of culture bottles that do not require venting and that use a liquid emulsion sensor was studied. | 2002 | 12147032 |
| distribution of rabies virus in infected mice, vaccinated and submitted to p. acnes as immunomodulator. | the lethality and distribution of rabies virus were evaluated in swiss mice experimentally infected with street rabies virus, vaccinated and submitted to immunomodulation by p .acnes (formerly corynebacterium parvum). the animals were sacrificed at different times,when the different tissues were collected and submitted to fluorescent antibody test (fat) and mouse inoculation test (mit). the group submitted to vaccination and p. acnes treatment presented a percentage of survival superior to that ... | 2002 | 12135238 |
| [postoperative subdural empyema due to propionibacterium acnes]. | propionibacterium acnes are gram-positive pleomorphic rods that grow under an anaerobic condition. they are the most frequent inhabitants of sebaceous glands of skin, hair follicles, mouth, upper respiratory tract, and as a frequent contaminant in laboratory cultures. propionibacterium acnes is an underestimated but significant cause of postneurosurgical infection, especially in the presence of foreign bodies such as shunt systems. we present a rare case with a postoperative subdural empyema in ... | 2002 | 12134669 |
| activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. | one of the factors that contributes to the pathogenesis of acne is propionibacterium acnes; yet, the molecular mechanism by which p. acnes induces inflammation is not known. recent studies have demonstrated that microbial agents trigger cytokine responses via toll-like receptors (tlrs). we investigated whether tlr2 mediates p. acnes-induced cytokine production in acne. transfection of tlr2 into a nonresponsive cell line was sufficient for nf-kappa b activation in response to p. acnes. in additio ... | 2002 | 12133981 |
| removal of common fusarium toxins in vitro by strains of lactobacillus and propionibacterium. | this study was conducted to examine the ability of selected strains of lactobacillus and propionibacterium to remove common fusarium toxins, trichothecenes, from liquid media. the trichothecenes studied were deoxynivalenol (don), 3-acetyldeoxynivalenol (3-acdon), nivalenol (niv), fusarenon (fx), diacetoxyscirpenol (das), t-2 toxin (t-2) and ht-2 toxin (ht-2). the lactobacillus rhamnosus strain gg (lgg), lactobacillus rhamnosus strain lc-705 (lc-705) and propionibacterium freudenreichii ssp. sher ... | 2002 | 12113664 |
| some factors affecting the adherence of probiotic propionibacterium acidipropionici crl 1198 to intestinal epithelial cells. | adhesion to the intestinal mucosa is generally considered an important property of probiotic microorganisms and has been related to many of their health benefits. this study investigated some factors that could affect or be involved in the adherence of propionibacterium acidipropionici crl 1198, a dairy strain with suggested probiotic effects and high adherence in vitro and in vivo to intestinal epithelial cells. in vitro adhesion of propionibacteria was decreased by gastric digestion but not af ... | 2002 | 12109885 |
| diversion of first blood volume results in a reduction of bacterial contamination for whole-blood collections. | in a previous study we established a reliable setpoint for the prevalence of bacteria in whole blood. in the present study we investigated the possible preventive effect, of diversion of the first 10 ml of a blood donation, on the bacterial contamination rate. | 2002 | 12100383 |
| invasion of dentinal tubules by oral bacteria. | bacterial invasion of dentinal tubules commonly occurs when dentin is exposed following a breach in the integrity of the overlying enamel or cementum. bacterial products diffuse through the dentinal tubule toward the pulp and evoke inflammatory changes in the pulpo-dentin complex. these may eliminate the bacterial insult and block the route of infection. unchecked, invasion results in pulpitis and pulp necrosis, infection of the root canal system, and periapical disease. while several hundred ba ... | 2002 | 12097359 |
| diagnosis of pelvic actinomycosis by 16s ribosomal rna gene sequencing and its clinical significance. | traditional ways of identification of anaerobic gram-positive non-sporulating bacilli by isolation of the organism and studying it phenotypically by elucidation of its morphologic and biochemical characteristics and metabolic end products are associated with a need for special equipment and expertise, and strains that are "unidentified" because of ambiguous biochemical profiles. in this study, an anaerobic gram-positive non-sporulating bacterium was isolated from the intrauterine contraceptive d ... | 2002 | 12088617 |
| propionibacterium acnes-induced il-8 production may be mediated by nf-kappab activation in human monocytes. | propionibacterium acnes (p. acnes) causes an inflammatory acne that is characterized by massive neutrophilic infiltration. il-8 is thought to play an important role in the pathophysiology of p. acnes, although the mechanisms by which p. acnes up-regulates the release of il-8, a neutrophilic chemokine, from target cells is not well understood. in this study, we investigated the mechanisms through which heat-killed p. acnes induces il-8 production in thp-1 cells (a human monocytic cell line). we f ... | 2002 | 12088610 |
| effect of topical benzoyl peroxide/clindamycin versus topical clindamycin and vehicle in the reduction of propionibacterium acnes. | propionibacterium acnes is one of the primary factors involved in the pathogenesis of acne vulgaris; proliferation of this bacteria is present in all patients with inflammatory lesions. combination topical therapy with agents that have different but complementary antimicrobial mechanisms of action has the potential to increase efficacy and to prevent the emergence of resistant organisms. the onset of action and effectiveness of 3 topical preparations (benzoyl peroxide 5%/clindamycin phosphate 1% ... | 2002 | 12078851 |
| levofloxacin is effective for inflammatory acne and achieves high levels in the lesions: an open study. | 2002 | 12077528 | |
| effects of roxithromycin on the production of lipase and neutrophil chemotactic factor by propionibacterium acnes. | the macrolide antibiotic roxithromycin is effective against acne associated with inflammation, but the mechanism by which this is achieved has not been clarified. | 2002 | 12077521 |
| detection of aminotransferase activity of propionibacterium freudenreichii after sds-page. | aminotransferases (ats) had previously been detected after native electrophoresis. we show now that aminotransferase(s) of propionibacterium freudenreichii can be detected after sodium dodecyl sulphate-polyacrylamide gel electrophoresis (sds-page). moreover, it retained a high activity (84%) in the presence of 0.23% sds, contrary to what was observed for aminotransferase(s) of bifidobacterium bifidum (54%) and of six other cheese-related species (0-20%). | 2002 | 12069890 |
| clindamycin/benzoyl peroxide gel: a review of its use in the management of acne. | clindamycin/benzoyl peroxide gel has demonstrated clinical efficacy in the treatment of acne vulgaris through both antibacterial and anti-inflammatory means. benzoyl peroxide may exert its antibacterial activity by the interaction of oxidized intermediates with elements of bacterial cells. clindamycin inhibits bacterial protein synthesis by binding to the 50s ribosomal subunits causing inhibition of peptide-bond formation. benzoyl peroxide decreases inflammatory damage by inhibiting the release ... | 2002 | 12069641 |
| ifngamma and tnfalpha account for a pro-clonogenic activity secreted by activated murine peritoneal macrophages. | in the present study, we found that murine peritoneal macrophages elicited by bcg or listeria monocytogenes release into the media an activity capable of stimulating the lung colonization as well as the expression of mhc class i antigens in b16 melanoma cells. a similar activity has previously been found in media conditioned by corynebacterium parvum-elicited macrophages. analysis by gel filtration chromatography of media conditioned by corynebacterium parvum-, bcg- or listeria monocytogenes-eli ... | 2002 | 12067206 |
| an antimicrobial peptide is produced by extracellular processing of a protein from propionibacterium jensenii. | a protease-activated antimicrobial peptide (pamp) and its inactive precursor were purified from the culture supernatant of propionibacterium jensenii lmg 3032 and characterized at the molecular level. pamp is a 64-amino-acid cationic peptide of 6,383 da with physicochemical features similar to those of bacteriocins from gram-positive bacteria. this peptide displayed bactericidal activity against several propionibacteria and lactobacilli. dna sequencing indicated that the pamp-encoding gene (pama ... | 2002 | 12057960 |
| isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin b12) in propionibacterium freudenreichii (p. shermanii). | a search for genes encoding enzymes involved in cobalamin (vitamin b12) production in the commercially important organism propionibacterium freudenreichii (p. shermanii) has resulted in the isolation of an additional 14 genes encoding enzymes responsible for 17 steps of the anaerobic b12 pathway in this organism. all of the genes believed to be necessary for the biosynthesis of adenosylcobinamide from uroporphyrinogen iii have now been isolated except two (cbia and an as yet unidentified gene en ... | 2002 | 12055304 |
| [general antibiotic therapy in acne]. | the primary indication for systemic antibiotics is acute therapy for moderate-to-severe inflammatory acne. the preferred agents include tetracyclines and derivatives; macrolides, co-trimoxazole, and trimethoprim may represent acceptable alternatives. antibiotics act mainly on inflammatory lesions (papules and pustules) and are only slightly comedolytic. oral antibiotics reduce the number of propionibacterium acnes. in addition, they have an anti-inflammatory activity. the side effects associated ... | 2002 | 12053791 |
| [mechanisms and causes of acne]. | three pathogenic factors are closely involved in the mechanism of acne with a sequence beginning with seborrhea, then sebum retention, and finally inflammation. the sebaceous gland is a target of androgens. acne may be related to an excessive sensitivity of sebaceous end-organs to androgens. however, in women, an ovarian or adrenal hyperandrogenism may be implicated. the cause of sebum retention is the hyperkeratinisation of the infra infundibulum of the sebaceous duct. many factors, particularl ... | 2002 | 12053788 |
| energetics and kinetics of lactate fermentation to acetate and propionate via methylmalonyl-coa or acrylyl-coa. | fermentation balances and growth yields were determined with various bacteria fermenting lactate to acetate plus propionate either via methylmalonyl-coa or via acrylyl-coa. all strains fermented lactate to acetate plus propionate at approximately a 1:2 ratio. growth yields of propionibacterium freudenreichii were more than twice as high as those of clostridium homopropionicum or veillonella parvula. hydrogen was formed as a side product to a significant extent only by v. parvula and pelobacter p ... | 2002 | 12052552 |
| looking back to the future--acne. | 2002 | 12037442 | |
| prevalent bacterial species and novel phylotypes in advanced noma lesions. | the purpose of this study was to determine the bacterial diversity in advanced noma lesions using culture-independent molecular methods. 16s ribosomal dna bacterial genes from dna isolated from advanced noma lesions of four nigerian children were pcr amplified with universally conserved primers and spirochetal selective primers and cloned into escherichia coli. partial 16s rrna sequences of approximately 500 bases from 212 cloned inserts were used initially to determine species identity or close ... | 2002 | 12037085 |
| bacterial populations on high-dk silicone hydrogel contact lenses: effect of length of wear in asymptomatic patients. | ocular infection and inflammation during extended wear with hydrogel lenses are often associated with contamination of the lenses with bacteria. this study examines the colonisation of a high-dk silicone hydrogel contact lens worn on a 30-night extended wear basis (continuous wear) during asymptomatic lens wear. | 2002 | 12033979 |
| induction of macrophage-inflammatory protein-3alpha gene expression by tnf-dependent nf-kappab activation. | macrophage-inflammatory protein-3alpha (mip-3alpha), also designated as liver and activation-regulated chemokine (larc), exodus, or ccl20, is a recently identified cc chemokine that is expected to play a crucial role in the initiation of immune responses. in this study, we describe that mip-3alpha expression is under the direct control of nf-kappab, a key transcription factor of immune and inflammatory responses. overexpression of the p65/rela subunit of nf-kappab significantly increased the mip ... | 2002 | 12023359 |
| pivotal role of dendritic cell-derived cxcl10 in the retention of t helper cell 1 lymphocytes in secondary lymph nodes. | various immune diseases are considered to be regulated by the balance of t helper (th)1 and th2 subsets. although th lymphocytes are believed to be generated in draining lymph nodes (lns), in vivo th cell behaviors during th1/th2 polarization are largely unexplored. using a murine granulomatous liver disease model induced by propionibacterium acnes, we show that retention of th1 cells in the lns is controlled by a chemokine, cxcl10/interferon (ifn) inducible protein 10 produced by mature dendrit ... | 2002 | 12021306 |
| perianal abscess caused by propionibacterium avidum in a cirrhotic patient. | we describe the first case of community-acquired propionibacterium avidum subcutaneous tissue infection in a cirrhotic patient. a 70-year-old chinese male with a 2-year history of hepatitis b virus-induced chronic liver failure and hemorrhoidectomy 17 months previously presented with a painful left buttock abscess, which was culture positive for p. avidum. being a normal flora of skin with low pathogenicity, there have been only 3 case reports on p. avidum infection, all associated with surgical ... | 2002 | 12019732 |
| the effects of an immediately pre-surgical chlorhexidine oral rinse on the bacterial contaminants of bone debris collected during dental implant surgery. | dental implant surgery produces bone debris that can be used in the "simultaneous augmentation" technique. although this debris is contaminated with oral bacteria, a stringent aspiration protocol has been shown to reduce the levels of contamination. chlorhexidine mouthrinse is a well-proven antibacterial rinse that has been shown to reduce infectious complications associated with dental implants. this study examined the effect of pre-operative rinsing with a 0.1% chlorhexidine digluconate mouthr ... | 2002 | 12005141 |