Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| inhibition of pathogen-induced apoptosis by a coxiella burnetii type iv effector protein. | coxiella burnetii and legionella pneumophila are evolutionarily related pathogens with different intracellular infection strategies. c. burnetii persists within and is transmitted by mammalian hosts, whereas, l. pneumophila is found primarily in the environment associated with protozoan hosts. although a type iv secretion system encoded by the defect in organelle trafficking (dot) and intracellular multiplication (icm) genes is a virulence determinant that remains highly conserved in both bacter ... | 2010 | 20944063 |
| [q fever]. | 2010 | 20942052 | |
| the early secretory pathway contributes to the growth of the coxiella-replicative niche. | coxiella burnetii is a gram-negative obligate intracellular bacterium. after internalization, this bacterium replicates in a large parasitophorous vacuole that has features of both phagolysosomes and autophagosomal compartments. we have previously demonstrated that early after internalization coxiella phagosomes interact with both the endocytic and the autophagic pathways. in this report, we present evidence that the coxiella-replicative vacuoles (crvs) also interact with the secretory pathway. ... | 2010 | 20937765 |
| coxiella burnetii infection of left atrial thrombus mimicking an atrial myxoma. | infection of intracardiac thrombi is extremely unusual. coxiella burnetii is a well-recognized etiologic agent of negative-blood culture endocarditis and vascular graft infection. herein we describe the first reported case, to our knowledge, of c. burnetii infection of a large left-sided intracardiac thrombus that was initially misdiagnosed as an atrial myxoma. diagnosis was confirmed by direct immunofluorescence assay, electron microscopy, and c. burnetii-specific polymerase chain reaction anal ... | 2010 | 20932487 |
| the q fever epidemic in the netherlands: history, onset, response and reflection. | the 2007-2009 human q fever epidemic in the netherlands attracted attention due to its magnitude and duration. the current epidemic and the historical background of q fever in the netherlands are reviewed according to national and international publications. seroprevalence studies suggest that q fever was endemic in the netherlands several decades before the disease was diagnosed in dairy goats and dairy sheep. this was in 2005 and the increase in humans started in 2007. q fever abortions were r ... | 2010 | 20920383 |
| a serosurvey of coxiella burnetii infection in children and young adults in south west queensland. | to describe the seroepidemiology of coxiella burnetii, the causative agent of q fever, in those under 25 years of age in south west queensland. | 2010 | 20920110 |
| uk role 4 military infectious diseases at birmingham heartlands hospital in 2005-9. | infectious diseases affecting british troops are mostly due to gastrointestinal and respiratory illnesses, but these are usually minor in severity, easy to manage and short in duration. to assess the importance of infections that are more severe, difficult to manage or longer in duration, it is necessary to look at military cases that are evacuated or otherwise referred to the uk role 4 (definitive care) medical facility for infectious diseases. | 2010 | 20919617 |
| pathogens and symbionts in ticks: a survey on tick species distribution and presence of tick-transmitted micro-organisms in sardinia, italy. | a total of 1485 adult ticks were collected from mammalian hosts in south-eastern sardinia, italy, during the years 2007-2008. ticks were identified and tested by pcr analysis for presence of rickettsia species of the spotted fever group, ehrlichia canis, anaplasma phagocytophilum, coxiella burnetii, bartonella species and leishmania species. among all tick species examined (rhipicephalus sanguineus, rhipicephalus turanicus, rhipicephalus bursa, rhipicephalus pusillus, hyalomma marginatum margina ... | 2010 | 20884769 |
| seroepidemiologic survey for coxiella burnetii among hospitalized us troops deployed to iraq*. | q fever is a zoonotic illness which frequently has a non-specific clinical presentation. cases among deployed us military personnel have been reported in increasing numbers indicating an emerging at-risk occupational group. banked serum specimens were utilized to estimate seroprevalence and risk factors among military personnel deployed to iraq. coxiella burnetii antibody testing was performed and epidemiologic data were analysed from 909 servicemembers. the overall number who seroconverted to q ... | 2010 | 20880090 |
| coxiella burnetii expresses a functional δ24 sterol reductase. | coxiella burnetii, the etiological agent of human q fever, occupies a unique niche inside the host cell, where it replicates in a modified acidic phagolysosome or parasitophorous vacuole (pv). the pv membrane is cholesterol-rich, and inhibition of host cholesterol metabolism negatively impacts pv biogenesis and pathogen replication. the precise source(s) of pv membrane cholesterol is unknown, as is whether the bacterium actively diverts and/or modifies host cell cholesterol or sterol precursors. ... | 2010 | 20870767 |
| rats as indicators of the presence and dispersal of six zoonotic microbial agents in cyprus, an island ecosystem: a seroepidemiological study. | a total of 622 rats (402 rattus norvegicus and 220 r. rattus frugivorus) were collected in 51 different areas in cyprus during 2000-2003 and used as indicators of the presence and dispersal of six zoonotic microbial agents. igg antibodies against rickettsia typhi (241/496, 48.6%), r. conorii (209/500, 41.8%), toxoplasma sp. (138/494, 27.9%), coxiella burnetti (63/494, 12.8%), bartonella henselae (52/494, 10.5%) and leishmania infantum (36/494, 7.3%) were detected by indirect immunofluorescence t ... | 2010 | 20870259 |
| principles of antidote pharmacology: an update on prophylaxis, post-exposure treatment recommendations and research initiatives for biological agents. | the use of biological agents has generally been confined to military-led conflicts. however, there has been an increase in non-state-based terrorism, including the use of asymmetric warfare, such as biological agents in the past few decades. thus, it is becoming increasingly important to consider strategies for preventing and preparing for attacks by insurgents, such as the development of pre- and post-exposure medical countermeasures. there are a wide range of prophylactics and treatments being ... | 2010 | 20860656 |
| [laboratory diagnosis of acute q fever]. | in the netherlands an increasing number of laboratories are involved in diagnosing acute q-fever. more uniformity in diagnostics and interpretation is desirable. to enable this, a working group on diagnostics of acute q-fever was created on the initiative of the national institute for public health and the environment (rivm) and the dutch association for medical microbiology (nvmm). the diagnostics of acute q-fever includes a diagnostic flow chart (algorithm) consisting of tests for dna and for ... | 2010 | 20858325 |
| one-year follow-up of patients of the ongoing dutch q fever outbreak: clinical, serological and echocardiographic findings. | in 2007, a large goat-farming-associated q fever outbreak occurred in the netherlands. data on the clinical outcome of dutch q fever patients are lacking. the current advocated follow-up strategy includes serological follow-up to detect evolution to chronic disease and cardiac screening at baseline to identify and prophylactically treat q fever patients in case of valvulopathy. however, serological follow-up using commercially available tests is complicated by the lack of validated cut-off value ... | 2010 | 20857313 |
| coxiella burnetii nine mile ii proteins modulate gene expression of monocytic host cells during infection. | coxiella burnetii is an intracellular bacterial pathogen that causes acute and chronic disease in humans. bacterial replication occurs within enlarged parasitophorous vacuoles (pv) of eukaryotic cells, the biogenesis and maintenance of which is dependent on c. burnetii protein synthesis. these observations suggest that c. burnetii actively subverts host cell processes, however little is known about the cellular biology mechanisms manipulated by the pathogen during infection. here, we examined ho ... | 2010 | 20854687 |
| diagnosis of acute q fever with emphasis on enzyme-linked immunosorbent assay and nested polymerase chain reaction regarding the time of serum collection. | a commercially available enzyme-linked immunosorbent assay (elisa) (virion/serion [wuerzburg, germany]), an indirect fluorescent antibody test (ifat) (bios/focus [cypress, ca]), and a nested polymerase chain reaction (pcr) were explored for diagnosis of acute q fever in reference to time of serum collection. serum samples of 22 patients with acute q fever collected around the fifth day of illness were included. a sensitivity of 30% by elisa and 80% by ifat (p = 0.1) was found for the first 5 day ... | 2010 | 20846582 |
| tortoise tick hyalomma aegyptium as long term carrier of q fever agent coxiella burnetii--evidence from experimental infection. | the experimental study investigated the ability of tortoise tick hyalomma aegyptium to play a role in forming and maintaining natural foci of q fever. we tested the competence of h. aegyptium larvae to acquire coxiella burnetii infection from mammals, serve as a c. burnetii vector between mammalian hosts, and be a long-term carrier of c. burnetii, including interstadial transmission. h. aegyptium larvae were allowed to feed on guinea pigs experimentally infected with c. burnetii. engorged larvae ... | 2010 | 20827490 |
| interlaboratory evaluation of different extraction and real-time pcr methods for detection of coxiella burnetii dna in serum. | in the netherlands, there is an ongoing and unparalleled outbreak of q fever. rapid and reliable methods to identify patients infected with coxiella burnetii, the causative agent of q fever, are urgently needed. we evaluated the performance of different dna extraction methods and real-time pcr assays that are in use in seven diagnostic or reference laboratories in the netherlands. a low degree of variation in the sensitivities of most of the developed real-time pcr assays was observed. however, ... | 2010 | 20826645 |
| matrix-assisted laser desorption ionization time-of-flight mass spectrometry: usefulness for taxonomy and epidemiology. | matrix-assisted laser desorption ionization time-of-flight (maldi-tof) mass spectrometry (ms) is a powerful tool for the species and subspecies classification of a broad spectrum of bacteria, including gram-positive bacteria such as staphylococcus, streptococcus and listeria, and gram-negative bacteria such as neisseria, salmonella, aeromonas, campylobacter and helicobacter. maldi-tof ms has also been used for the rapid identification and typing of potential bioterrorism agents, including coxiel ... | 2010 | 20825435 |
| characterization of antigens for q fever serodiagnostics. | the aim of this study was to identify candidate proteins for serodiagnostics of q fever by monoclonal antibodies (mabs), and to clone, express, and purify the selected proteins for use as antigens in elisa. the reactivity of three mabs to coxiella burnetii (c. b.) nine mile strain and one mab to priscilla strain was tested using sds-page, 2-d gel electrophoresis, immunoblot analysis, and mass spectrometry. three immunoreactive q fever-specific proteins discriminated by mabs, namely the cbu_0937 ... | 2010 | 20822309 |
| q fever, free amoeba, and air conditioning. | 2010 | 20809841 | |
| detailed analysis of health status of q fever patients 1 year after the first dutch outbreak: a case-control study. | q fever is a zoonosis caused by the obligate intracellular bacterium coxiella burnetii. the two long-term complications, after primary infection, are chronic q fever in ∼1% of patients, and a chronic fatigue syndrome in 10-20%. however, the existence of a protracted decreased health status after q fever remains controversial. | 2010 | 20802011 |
| unexpected renal and liver failure. | 2010 | 20800146 | |
| [improvement of method of coxiella burnetii detection in biological material based on groel gene amplification]. | improvement of pcr for detection of coxiella burnetii in field material by development of set of primers for amplification of groel gene fragment. | 2010 | 20799401 |
| q fever endocarditis. | 1976 | 20792429 | |
| q fever. | 1956 | 20788609 | |
| q fever. | 1954 | 20788212 | |
| q fever in england. | 1950 | 20787757 | |
| relapsing uveitis and optic neuritis due to chronic q fever. | 2011 | 20733024 | |
| sex-related differences in gene expression following coxiella burnetii infection in mice: potential role of circadian rhythm. | q fever, a zoonosis due to coxiella burnetii infection, exhibits sexual dimorphism; men are affected more frequently and severely than women for a given exposure. here we explore whether the severity of c. burnetii infection in mice is related to differences in male and female gene expression profiles. | 2010 | 20730052 |
| coxiella burnetii type ivb secretion system region i genes are expressed early during the infection of host cells. | analysis of the coxiella burnetii rsa 493 (nine mile phase i strain) genome revealed orfs with significant homology to the type ivb secretion system (t4bss) of legionella pneumophila. the t4bss genes exist primarily at two loci, designated regions i (ri) and ii. in c. burnetii, little is known about the t4bss regions and the role they play in establishing and/or maintaining infection. coxiella burnetii t4bss ri contains genes arranged in three linkage groups: (1) icmw→cbu1651→icmx, (2) icmv→dota ... | 2010 | 20727011 |
| coxiella burnetii infections in domestic ruminants in canary islands (spain). | 2010 | 20723162 | |
| dose-response model of coxiella burnetii (q fever). | q fever is a zoonotic disease caused by the intracellular gram-negative bacterium coxiella burnetii (c. burnetii), which only multiplies within the phagolysosomal vacuoles. q fever may manifest as acute or chronic disease. the acute form is generally not fatal and manifestes as self-controlled febrile illness. chronic q fever is usually characterized by endocarditis. many animal models, including humans, have been studied for q fever infection through various exposure routes. the studies conside ... | 2011 | 20723147 |
| coxiella burnetii abortion in captive dama gazelle (gazella dama) in the united arab emirates. | abstract: five cases of late-stage abortion in dama gazelle (gazella dama) occurred in the united arab emirates. histopathologic and molecular diagnostics found the abortions to be associated with coxiella burnetii infection. examination of the herd 6 mo later revealed a significant number of serologically positive animals but failed to detect the antigen in genital swabs. there are few reports in the literature of c. burnetii abortion in nondomestic ungulates and no published reports from the u ... | 2010 | 20722258 |
| hijacked phagosomes and leukocyte activation: an intimate relationship. | intracellular pathogens have developed different strategies to survive within host cells. for example, these pathogens might interfere with the biogenesis of phagolysosomes, thereby forming replicative vacuoles. although the complex mechanisms used by pathogens to hijack the biogenesis of phagolysosomes have been elucidated in naive leukocytes, the role of leukocyte activation in this process has not yet been investigated. leukocytes are known to be activated by cytokines, and several reports ha ... | 2011 | 20720162 |
| screening of nitrosative stress resistance genes in coxiella burnetii: involvement of nucleotide excision repair. | coxiella burnetii, an obligate intracellular gram-negative bacterium, is the etiological agent of q fever. this work takes advantage of a hypersensitive escherichia coli genetic system to identify genes involved in resistance to nitrosative stress imposed by reactive nitrogen intermediates. among the ten candidate genes identified, the transposase, uvrb and dna topoisomerase iv are involved in dna transaction; the sigma-32 factor and the putative dna-binding protein may be involved in transcript ... | 2010 | 20705129 |
| detection of coxiella burnetii in commercially available raw milk from the united states. | unpasteurized (raw) milk can be purchased in 39 u.s. states, with direct consumer purchase for human consumption permitted in 29 of those 39 states. raw milk (n=21; cow, 14; goat, 7) was purchased in 12 states, and coxiella burnetii, the agent of q fever, was detected in 9 of 21 (42.9%) samples tested by polymerase chain reaction. viability of the pathogen was demonstrated by isolation of the agent in tissue culture. the demonstration of viable c. burnetii in commercially available raw milk pose ... | 2010 | 20704507 |
| [screening for chronic q fever in symptomatic patients with an aortic aneurysm or prosthesis]. | a 76-year-old man was referred to the emergency department because of collapse, epigastric pain and nausea. the patient had been diagnosed with an infrarenal aneurysm of the abdominal aorta nine years earlier. his symptoms were attributed to an aortic-duodenal fistula originating from the aneurysm. the patient died despite placement of an aortic prosthesis. a hospital screening programme for chronic q fever in patients with aortic aneurysm revealed chronic q fever. until recently, vascular infec ... | 2010 | 20699030 |
| [hepatic granulomas in a feverish patient]. | fever of unknown origin is a diagnostic challenge. when the diagnosis remains elusive despite extensive non-invasive diagnostic studies, it can be necessary to conduct more invasive procedures, such as liver biopsy. we report a male with fever of unknown origin who had tender enlarged liver and raised liver enzymes whose hepatic biopsy disclosed epithelioid granulomas, with the etiological diagnosis made by the positivity of coxiella burnetii serology. | 2010 | 20688000 |
| [prolonged fever and jaundice in a patient with alcoholic liver disease]. | we report the case of a 40-year-old man with underlying alcoholic liver disease who presented with prolonged fever, jaundice and liver failure associated with coxiella burnetii infection. after diagnosis and appropriate antibiotic treatment, the patient made a complete recovery. we describe aspects of this case and provide a practical review of the literature on the topic. we also discuss the importance of this infection and the need for its inclusion in the differential diagnosis of this clinic ... | 2010 | 20685010 |
| long-term persistence after acute q fever of non-infective coxiella burnetii cell components, including antigens. | previous studies of inciting factors for a prolonged post-infection fatigue syndrome after q fever (variously termed qfs or q fever associated cfs/me in the literature) showed that after the acute infection a high proportion of asymptomatic and qfs patients had q fever antibody and also low levels in pbmc and bone marrow of coxiella burnetii (c.b.) dna with pcr assays directed against three different target sequences in different parts of the coxiella genome. attempts to isolate a strain of c.b. ... | 2010 | 20639288 |
| q fever endocarditis. | 2010 | 20637695 | |
| long-term outcome of q fever endocarditis: a 26-year personal survey. | q fever endocarditis caused by coxiella burnetii is a potentially fatal disease characterised by a chronic evolution. to assess the long-term outcome and identify prognostic factors for mortality, surgical treatment, and serological changes in q fever endocarditis, we did a retrospective study in the french national referral centre. | 2010 | 20637694 |
| q fever serology in febrile patients in southeast iran. | there is little information on human q fever in iran and other middle east countries. the aim of this study was to determine apparent q fever seropositivity among febrile patients with suspected brucellosis in southeast iran. coxiella burnetii phases i and ii specific igg antibodies were measured by a commercial enzyme-linked immunosorbent assay (elisa) in sera from 75 febrile patients. phase i antibodies were detected in 18 subjects (24%) and phase ii antibodies in 27 subjects (36%). this is th ... | 2010 | 20627331 |
| [three years of q fever in the netherlands: faster diagnosis]. | to assess if more rapid diagnosis and treatment is possible and to assess if this could be improved, since the first outbreak of q fever in 2007. | 2010 | 20619049 |
| a rare granulomatous reaction to q fever vaccination following influenza vaccination. | 2010 | 20618120 | |
| [experimental study of relations of the argasid ticks alveonasus lahorensis with coxiella burnetii]. | the argasid ticks a. lahorensis can be infected with coxiella burnetii on feeding on an infected rabbit. the adoptive pathogen reproduces in the ticks and accumulates in them up to 10(10) id50 g(-1). coxiella persists in the ticks at this level up to 156 days (the time of observation). the infected ticks transmit coxiella to guinea pigs while sucking. the ticks show transovarial transmission of coxilla during metamorphosis. on this basis and with consideration for the fact that a. lahorensis use ... | 2010 | 20608184 |
| optic neuritis associated with q fever: case report and literature review. | optic neuritis (on) is a rare association of q fever. we report the first case of on associated with q fever in australia and review all previously reported cases in the medical literature. the impact of therapy with antibiotics and steroids on outcome is discussed. q fever should be considered in the differential diagnosis of patients presenting with apparent acute idiopathic on. | 2010 | 20605503 |
| studies on the microscopic slide-agglutination test for q fever. | the author has devised a micro-agglutination test for the sero-diagnosis of q fever. preliminary studies had already indicated that it was highly sensitive, and this has now been confirmed. using the sera of sheep infected with q fever, the microscopic slide-agglutination test was found to be approximately 10 times as sensitive as the capillary agglutination test and the macroscopic tube-agglutination test, and more than 20 times as sensitive as the complement-fixation test. the sensitivity of t ... | 1958 | 20604046 |
| epidemiological investigations on q fever in turkey. | q fever is endemic in turkey in both human beings and animals. cows, sheep, goats, and dogs may play a role as reservoirs of coxiella burnetii. ornithodorus lahorensis ticks also harbour the agent. the disease is disseminated throughout turkey; epidemics among human beings are relatively rare. | 1953 | 20603969 |
| pentamidine inhibits coxiella burnetii growth and 23s rrna intron splicing in vitro. | coxiella burnetii is the bacterial agent of q fever in humans. acute q fever generally manifests as a flu-like illness and is typically self-resolving. in contrast, chronic q fever usually presents with endocarditis and is often life-threatening without appropriate antimicrobial therapy. unfortunately, available options for the successful treatment of chronic q fever are both limited and protracted (>18 months). pentamidine, an rna splice inhibitor used to treat fungal and protozoal infections, ... | 2010 | 20599360 |
| circulating cytokines and procalcitonin in acute q fever granulomatous hepatitis with poor response to antibiotic and short-course steroid therapy: a case report. | q fever is a zoonosis distributed worldwide that is caused by coxiella burnetii infection and the defervescence usually occurs within few days of appropriate antibiotic therapy. whether the changes of cytokine levels are associated with acute q fever with persistent fever despite antibiotic therapy had not been investigated before. | 2010 | 20594295 |
| coxiella burnetii infection of a steller sea lion (eumetopias jubatus) found in washington state. | a pregnant sea lion stranded in the state of washington was found to have placentitis caused by a unique strain of coxiella burnetii. this is the first description of coxiellosis in a sea lion and suggests that exposure to sea lions may be a risk factor for contracting q fever. | 2010 | 20592144 |
| fastidious intracellular bacteria as causal agents of community-acquired pneumonia. | intracellular bacteria are common causes of community-acquired pneumonia that grow poorly or not at all on standard culture media and do not respond to beta-lactam antibiotic therapy. apart from well-established agents of pneumonia such as legionella pneumophila, mycoplasma pneumoniae, chlamydia pneumoniae, chlamydia psittaci and coxiella burnetii, some new emerging pathogens have recently been recognized, mainly parachlamydia acanthamoebae and simkania negevensis, two chlamydia-related bacteria ... | 2010 | 20586563 |
| molecular investigation of the occurrence of coxiella burnetii in wildlife and ticks in an endemic area. | at present few studies have been carried out on the distribution and incidence of coxiella burnetii infection in wildlife. therefore, the aim of this study was to investigate the distribution of c. burnetii in the main wild species in the basque country (northern spain), such as carnivores, cervids, wild boar, lagomorphs and several species of birds. tissues from a total of 601 animals and 340 adult ticks collected from them were analyzed by pcr. dna of c. burnetii was detected in 5.1% of roe de ... | 2011 | 20580169 |
| dairy cows with metritis: coxiella burnetii test results in uterine, blood and bulk milk samples. | in cattle, coxiella burnetii infections are generally asymptomatic but can also be associated with reproductive disorders. metritis is considered as one of the symptoms of c. burnetii infections, but reliable information is lacking. therefore, information on the presence of c. burnetii in the uterine content of cows with metritis is important to increase our knowledge on this pathogen. in this study, the uterine content of 45 dairy cows with metritis belonging to 12 herds was tested for c. burne ... | 2011 | 20576366 |
| q fever as a cause of fever of unknown origin and thrombocytosis: first molecular evidence of coxiella burnetii in brazil. | we report a case of q fever in a man who presented with fever of 40 days duration associated with thrombocytosis. serological and molecular analysis (polymerase chain reaction) confirmed infection with coxiella burnetii. a field study was conducted by collecting blood samples from the patient's family and from the animals in the patient's house. the patient's wife and 2 of 13 dogs showed seroreactivity. our data indicate that c. burnetii may be an underrecognized cause of fever in brazil and emp ... | 2011 | 20569012 |
| 3d reconstruction of granulomas from transmitted light images implemented for long-time microscope applications. | image analysis tools are essential to describe and quantify dynamic biological phenomena, such as early stages of granuloma formation. granulomas are constituted of a collection of immune cells that contain pathogens, leading to their elimination. we presented here a new method to obtain granuloma 3d reconstruction from transmitted light images. granulomas were generated by incubating peripheral blood mononuclear cells with beads coated with sonicated coxiella burnetii, a bacterial pathogen. bio ... | 2010 | 20561526 |
| serological survey of five zoonoses, scrub typhus, japanese spotted fever, tularemia, lyme disease, and q fever, in feral raccoons (procyon lotor) in japan. | we investigated the seroprevalence of five tick- or mite-borne zoonoses, scrub typhus (orientia tsutsugamushi), japanese spotted fever (rickettsia japonica), tularemia (francisella tularensis), lyme disease (borrelia afzelii and borrelia garinii), and q fever (coxiella burnetii), in feral raccoons (procyon lotor) captured in hokkaido and kanagawa prefectures in japan. of the 559 raccoons captured in hokkaido, 8 (1.4%), 3 (0.5%), 1 (0.2%), and 1 (0.2%) carried antibodies against o. tsutsugamushi ... | 2011 | 20553108 |
| in this issue. | you give me fever all through the night...: peggy lee probably wasn't singing about q fever, a severe but self-limiting flu-like disease in humans caused by coxiella burnetii. it also infects a wide variety of wild and domesticated animals. although it is an obligate intracellular organism, it is environmentally rather stable, resistant to many decontamination methods and a potential bio-warfare agent. commercial diagnostic tests (complement fixation, indirect immunofluorescence) require purifie ... | 2010 | 20552582 |
| risk of exposure to q fever pathogen boosted by travel in iraq or netherlands. | 2010 | 20551401 | |
| comprehensive diagnostic strategy for blood culture-negative endocarditis: a prospective study of 819 new cases. | background. blood culture-negative endocarditis (bcne) may account for up to 31% of all cases of endocarditis. methods. we used a prospective, multimodal strategy incorporating serological, molecular, and histopathological assays to investigate specimens from 819 patients suspected of having bcne. results. diagnosis of endocarditis was first ruled out for 60 patients. among 759 patients with bcne, a causative microorganism was identified in 62.7%, and a noninfective etiology in 2.5%. blood was t ... | 2010 | 20540619 |
| seroprevalence of coxiella burnetii in domestic ruminants in gran canaria island, spain. | coxiella burnetii is the causative agent of q fever, a zoonosis with worldwide occurrence. in the canary islands, the overall seroprevalence in humans has been estimated to be 21.5%. gran canaria island concentrates the highest ruminant population in the archipelago and the prevalence of the human infection is 23.5%. to evaluate the seroprevalence in livestock and the affected areas in gran canaria island, a total of 1249 ruminants were randomly selected for this study (733 goats, 369 sheep and ... | 2010 | 20537108 |
| [q fever in wild animals in europe, attention to hunters]. | 2010 | 20524406 | |
| the first serologic study of q fever in sheep in iran. | coxiella burnetii is an obligate intracellular microorganism that causes q fever in humans and animals. in ewes, c. burnetii infections are generally asymptomatic, but they can lead to abortions, stillbirths, and delivery of weak and unviable lambs. serological assays are suitable for screening herds. enzyme-linked immunosorbent assays (elisa) technique has a high sensitivity and a good specificity. the aim of this study was to investigate the presence of anti-c. burnetii antibodies among sheep ... | 2010 | 20521106 |
| coxiella burnetii phase i and ii variants replicate with similar kinetics in degradative phagolysosome-like compartments of human macrophages. | coxiella burnetii infects mononuclear phagocytes, where it directs biogenesis of a vacuolar niche termed the parasitophorous vacuole (pv). owing to its lumenal ph (approximately 5) and fusion with endolysosomal vesicles, the pv is considered phagolysosome-like. however, the degradative properties of the mature pv are unknown, and there are conflicting reports on the maturation state and growth permissiveness of pv harboring virulent phase i or avirulent phase ii c. burnetii variants in human mon ... | 2010 | 20515926 |
| q fever outbreak in a small village, taiwan. | 2010 | 20495278 | |
| in search of hidden q-fever outbreaks: linking syndromic hospital clusters to infected goat farms. | large q-fever outbreaks were reported in the netherlands from may 2007 to 2009, with dairy-goat farms as the putative source. since q-fever outbreaks at such farms were first reported in 2005, we explored whether there was evidence of human outbreaks before may 2007. space-time scan statistics were used to look for clusters of lower-respiratory infections (lris), hepatitis, and/or endocarditis in hospitalizations, 2005-2007. we assessed whether these were plausibly caused by q fever, using patie ... | 2011 | 20478085 |
| the epidemiology of q fever. | 1944 | 20475697 | |
| presence of coxiella burnetii dna in the environment of the united states, 2006 to 2008. | coxiella burnetii is an obligate intracellular bacterium that causes the zoonotic disease q fever. because c. burnetii is highly infectious, can survive under a variety of environmental conditions, and has been weaponized in the past, it is classified as a select agent and is considered a potential bioweapon. the agent is known to be present in domestic livestock and in wild animal populations, but the background levels of c. burnetii in the environment have not been reported. to better understa ... | 2010 | 20472727 |
| [q fever already present for a longer time in the netherlands]. | 2010 | 20469578 | |
| q fever: clinical manifestations and treatment. | public awareness and advances in the diagnostic approach to q fever have provided important information on epidemiological and clinical aspects of this zoonosis. coxiella burnetii infection exhibits various acute or chronic clinical forms, and infection during pregnancy may jeopardize the integrity of the fetus. the presentation of infection is often nonspecific and this hinders prompt diagnosis. therapeutic regimens vary, and treating q fever during pregnancy and childhood is often challenging. ... | 2010 | 20455682 |
| spread of q fever within dairy cattle herds: key parameters inferred using a bayesian approach. | q fever is a worldwide zoonosis caused by coxiella burnetii. although ruminants are recognized as the most important source of human infection, no previous studies have focused on assessing the characteristics of the bacterial spread within a cattle herd and no epidemic model has been proposed in this context. we assess the key epidemiological parameters from field data in a bayesian framework that takes into account the available knowledge, missing data and the uncertainty of the observation pr ... | 2010 | 20444719 |
| dna gyrase and topoisomerase iv mutations in an in vitro fluoroquinolone-resistant coxiella burnetii strain. | the etiological agent of q fever, coxiella burnetii, is an obligate intracellular bacterium that multiplies within a vacuole with lysosomal characteristics. quinolones have been used as an alternative therapy for q fever. in this study, quinolone-resistance-determining regions of the genes coding for dna gyrase and topoisomerase iv were analyzed by dna sequencing from an in vitro fluoroquinolone-resistant c. burnetii strain (q212). sequencing and aligning of dna gyrase encoding genes (gyra and g ... | 2010 | 20438350 |
| [q fever: emotions and reality]. | 2010 | 20437904 | |
| practical method for extraction of pcr-quality dna from environmental soil samples. | methods for the extraction of pcr-quality dna from environmental soil samples by using pairs of commercially available kits were evaluated. coxiella burnetii dna was detected in spiked soil samples at <1,000 genome equivalents per gram of soil and in 12 (16.4%) of 73 environmental soil samples. | 2010 | 20435765 |
| a case of acute q fever with severe acute cholestatic hepatitis. | minimal hepatic dysfunction can be common in acute q fever, but severe acute cholestatic hepatitis is rarely reported. we report on a 55-year-old male with acute q fever and severe acute cholestatic hepatitis. he complained of fever, jaundice, ascites, and restlessness on admission. a liver biopsy revealed the presence of compact fibrin-ring granulomas. serologic titers for c. burnetii igm and igg were 2048:1 and 1024:1, respectively. c. burnetii dna was detected by a nested polymerase chain rea ... | 2009 | 20431739 |
| neospora caninum and coxiella burnetii seropositivity are related to endocrine pattern changes during gestation in lactating dairy cows. | q fever is a zoonotic infection caused by coxiella burnetii that is endemic worldwide. domestic ruminants are a source of infection for humans. given the suggestion that the bacterium recrudesces during pregnancy in cattle, this study was designed to determine whether c. burnetii infection affects hormonal patterns, such as progesterone, cortisol, pregnancy associated glycoproteins (pag), and prolactin during gestation in lactating cows. possible interactions with neospora caninum were also expl ... | 2010 | 20416940 |
| a large q fever outbreak in an urban school in central israel. | background. on 28 june 2005, numerous cases of febrile illness were reported among 322 students and employees of a boarding high school located in an urban area in central israel. subsequent investigation identified a large outbreak of q fever which started 2 weeks earlier. we describe the investigation of this outbreak and its possible implications. methods. we conducted a case-control study to identify risk factors for q fever disease. environmental sampling was conducted to identify the sourc ... | 2010 | 20415568 |
| genome-wide profiling of humoral immune response to coxiella burnetii infection by protein microarray. | comprehensive evaluation of the humoral immune response to coxiella burnetii may identify highly needed diagnostic antigens and potential subunit vaccine candidates. here we report the construction of a protein microarray containing 1901 c. burnetii orfs (84% of the entire proteome). this array was probed with q-fever patient sera and naïve controls in order to discover c. burnetii-specific seroreactive antigens. among the 21 seroreactive antigens identified, 13 were significantly more reactive ... | 2010 | 20391532 |
| coxiella burnetii in humans and ticks in rural senegal. | q fever is a worldwide zoonotic disease caused by coxiella burnetii. epidemiologically, animals are considered reservoirs and humans incidental hosts. | 2010 | 20386603 |
| serologic detection of a rare case of q fever in new york city having hepatic and unusual renal complications. | we describe the case of a 46-year-old resident of new york city with a one-year history of frequent urination and 3 weeks of undulating fevers. he also had liver and bone marrow abnormalities where a non-culturable gram-negative rod was identified. q fever was suspected and confirmed based on highly elevated phase i and ii serum igm/igg antibodies against coxiella burnetii. | 2010 | 20376527 |
| role of cd4+ and cd8+ t cells in clearance of primary pulmonary infection with coxiella burnetii. | the mechanisms of the primary adaptive immune response to coxiella burnetii are not well known. following inoculation of the lungs with c. burnetii nine mile phase i (nmi), scid mice developed pneumonia and splenomegaly and succumbed to infection, whereas wild-type mice cleared the infection by 24 days. scid mice reconstituted with either cd4+ t cells or cd8+ t cells alone were able to control the infection, indicating that the presence of either type of t cells was sufficient to control infecti ... | 2010 | 20351144 |
| q fever in the netherlands: an update on the epidemiology and control measures. | since the steady rise in human cases which started in 2007, q fever has become a major public health problem in the netherlands with 2,357 human cases notified in the year 2009. ongoing research confirms that abortion waves on dairy goat farms are the primary source of infection for humans, primarily affecting people living close (under 5 km) to such a dairy goat farm. to reverse the trend of the last three years, drastic measures have been implemented, including the large-scale culling of pregn ... | 2010 | 20350500 |
| q fever outbreak in cheltenham, united kingdom, in 2007 and the use of dispersion modelling to investigate the possibility of airborne spread. | we describe the investigation of an outbreak of q fever in the town of cheltenham, england. the outbreak was detected in june 2007, and prospective and retrospective case finding identified 30 confirmed or probable human cases. the investigation identified windborne spread of coxiella burnetii from nearby sheep farms as the most likely source of infection. a telephone survey was conducted to identify risk practices at local farms. subsequently the atmospheric dispersion model name was used to id ... | 2010 | 20350497 |
| a case of q fever probably contracted by exposure to ticks in nature. | 1947 | 20344767 | |
| vaccination against q fever. | 1947 | 20344306 | |
| [evaluation q fever handling]. | 2010 | 20334027 | |
| report of an outbreak of q fever at the national institute of health. | 1947 | 20292057 | |
| q fever in the united states; isolation and identification of rickettsias in an outbreak among stock handlers and slaughterhouse workers. | 1947 | 20285317 | |
| q fever in the united states; serologic observations in an outbreak among stock handlers and slaughterhouse workers. | 1947 | 20285316 | |
| q fever in the united states; clinical data on an outbreak among stock handlers and slaughterhouse workers. | 1947 | 20285315 | |
| q fever in the united states; epidemiologic studies of an outbreak among stock handlers and slaughterhouse workers. | 1947 | 20285314 | |
| hypertonic sodium chloride solution as serum diluent in agglutination tests with rickettsia burneti. | 1946 | 20274307 | |
| [not available]. | 1947 | 20268575 | |
| q fever a serological investigation of a group of cases previously reported as primary atypical pneumonia. | 1947 | 20268490 | |
| an outbreak of q fever in a chicago packing house. | 1947 | 20262044 | |
| q fever report of a case. | 1947 | 20259945 | |
| report on an outbreak of q fever at the national institute of health; clinical features. | 1947 | 20251773 | |
| the use of a geographic information system to identify a dairy goat farm as the most likely source of an urban q-fever outbreak. | a q-fever outbreak occurred in an urban area in the south of the netherlands in may 2008. the distribution and timing of cases suggested a common source. we studied the spatial relationship between the residence locations of human cases and nearby small ruminant farms, of which one dairy goat farm had experienced abortions due to q-fever since mid april 2008. a generic geographic information system (gis) was used to develop a method for source detection in the still evolving major epidemic of q- ... | 2010 | 20230650 |