Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| p16, ki-67, and bd proexc immunostaining: a practical approach for diagnosis of cervical intraepithelial neoplasia. | p16, ki-67, and bd proexc (tripath imaging, inc., burlington, nc) have each been shown to be helpful adjuncts in the diagnosis and grading of human papillomavirus-associated cervical intraepithelial neoplasia. however, no clear guidelines are available regarding their use in routine practice. this study was designed to evaluate the efficacy of the 3 stains alone and in combinations to determine the most useful strategy in the diagnosis of cervical intraepithelial neoplasia and provide guidance i ... | 2009 | 19269017 |
| increased risk of oncogenic human papillomavirus infections and incident high-grade cervical intraepithelial neoplasia among smokers: experience from the latin american screening study. | the purpose of this study was to assess the effect of smoking on the prevalence and incidence of high-risk human papillomavirus (hr-hpv) infection and cervical intraepithelial neoplasia (cin) in a large sample of latin american women. | 2009 | 19265732 |
| human papillomavirus negative but dyskaryotic cervical cytology: re-analysis of molecular testing. | evaluation of molecular human papillomavirus (hpv) testing into uk cervical screening programmes is underway. in south wales the current hpv prevalence in women attending routine screening is 13.5% with 76.3% hr hpv positive in cases with reported dyskaryotic cervical cytology [hibbitts s, jones j, powell n, dallimore n, mcrea j, beer h, et al. human papillomavirus prevalence in women attending routine cervical screening in south wales, uk: a cross-sectional study. br j cancer 2008;99(december ( ... | 2009 | 19264544 |
| [vaccine against human papilloma virus]. | genital human papilloma virus infection (hpv) is the most common sexually transmitted infection worldwide, it is the cause of genital warts, and it is related with cervical cancer, the second most common cause of death from cancer in women in america, and the first in underdeveloped countries, and it is related with penis and prostate cancer in males also, and with anal cancer in both genders. this review examines the most important actual facts about hpv infection, and the new prophylactic vacc ... | 2008 | 19263667 |
| etiologic heterogeneity for cervical carcinoma by histopathologic type, using comparative age-period-cohort models. | cervical carcinomas comprise two main histopathologic types, squamous cell carcinomas and adenocarcinomas. human papillomavirus (hpv) infections are causative for both types but the respective tumors may have different carcinogenic pathways. | 2009 | 19258470 |
| oncogenic hpv infection interrupts the expression of tumor-suppressive mir-34a through viral oncoprotein e6. | micrornas (mirna) play pivotal roles in controlling cell proliferation and differentiation. aberrant mirna expression in human is becoming recognized as a new molecular mechanism of carcinogenesis. however, the causes for alterations in mirna expression remain largely unknown. infection with oncogenic human papillomavirus types 16 (hpv16) and 18 (hpv18) can lead to cervical and other ano-genital cancers. here, we have demonstrated that cervical cancer tissues and cervical cancer-derived cell lin ... | 2009 | 19258450 |
| detection of human papillomavirus in oral squamous cell carcinoma, leukoplakia and lichen planus in thai patients. | although tobacco, alcohol abuse and betel nut chewing habit are well recognized risk factors for oral squamous cell carcinoma (oscc), there is evidence to indicate that human papillomavirus (hpv) may also play some inducing role. the purpose of this study was to investigate the presence of hpv in thai patients with oral squamous cell carcinoma, leukoplakia and lichen planus using the polymerase chain reaction (pcr). biopsies of oral squamous cell carcinoma, leukoplakia and lichen planus were obt ... | 2008 | 19256774 |
| computational prediction of nuclear localization signals and structural characteristics of 91 types of hpv e6 proteins. | human papillomaviruses (hpvs) are small dna tumor viruses that replicate and assemble exclusively in the nucleus. thus their proteins, including e6, must carry nuclear localization signals (nlss) to enter the nucleus. to analyze and to predict the nuclear localization signals and several post translational modifications by bioinformatics analysis, we obtained 91 e6 protein sequences from available databases. to investigate the localization of these sequences, we used hum-ploc software. homology ... | 2008 | 19256751 |
| effectiveness and cost effectiveness of human papillomavirus vaccine: a systematic review. | the recent approval of human papillomavirus (hpv) vaccine means that decision makers need information beyond that available from randomized clinical trials to recommend funding for this vaccination programme. modelling and economic studies have addressed some of those information needs. we conducted a qualitative systematic review to summarize the existing data. review articles were obtained from an extensive literature search on studies using mathematical modelling (either a markov or transmiss ... | 2009 | 19254046 |
| [hpv vaccine and cervical cancer prevention in general practice. survey conducted among general practitioners in the french departments of eure-et-loir and cher]. | general practitioners are the first line to promote the human papillomavirus vaccine in teenagers and young female adults. the goal of this study is: to describe the perception, in france, of this vaccine by the general practitioners in the first 6 months after the publication of national recommendations and reimbursement of this vaccine by the social security; to know the daily practice of the cervical cancer prevention. these questions were asked through a questionnaire sent to 545 general pra ... | 2008 | 19253788 |
| molecular targets for cancer chemoprevention. | vaccines targeting infections with hepatitis b virus, a risk factor for hepatocellular cancer, and human papillomavirus, a risk factor for cervical cancer, are considered major clinical cancer chemoprevention successes. molecularly targeted agents can prevent breast cancer (raloxifene and tamoxifen), colorectal adenomas (celecoxib), and prostate cancer (finasteride). nevertheless, the broad translation of chemoprevention to the clinic is not yet a reality. continuing research of molecular target ... | 2009 | 19247304 |
| currents in contemporary ethics: hpv vaccines, privacy, and public health. | 2009 | 19245609 | |
| determinants of stability for the e6 protein of papillomavirus type 16. | e6 is an oncoprotein produced by human papillomavirus (hpv). the e6 protein from high-risk hpv type 16 contains two zinc-binding domains with two c-x-x-c motifs each. e6 exerts its transforming functions through formation of a complex with e6ap, which binds p53 and stimulates its degradation. there have been few biophysical and structural studies due to difficulty in preparation of soluble protein; here we describe the preparation of soluble e6 constructs including the two separated zinc-binding ... | 2009 | 19244625 |
| proteomic analysis reveals the actin cytoskeleton as cellular target for the human papillomavirus type 8. | recent studies strongly support a role of human papillomavirus type 8 (hpv8) in non-melanoma skin cancer development. in this study, a quantitative two-dimensional (2d) differential gene expression (dige) gel approach combined with mass spectrometry has been used to identify proteins that are abundantly deregulated in primary human epidermal keratinocytes expressing hpv8 sequences. twenty six protein spots showed significant changes in the level of expression between keratinocytes expressing e7 ... | 2009 | 19243805 |
| prevalence, clearance, and incidence of anal human papillomavirus infection in hiv-infected men: the hipvirg cohort study. | human immunodeficiency virus (hiv)-seropositive men who have sex with men (msm) are at higher risk of human papillomavirus (hpv) infection. this study was conducted to better understand the natural history of type-specific hpv infection in the anus. | 2009 | 19239366 |
| school nurses' workloads: how should they be prioritised? | the school nurse role has developed considerably over the past two decades in order to meet the changing health needs of the school-age population. changes demand continuous adaptability to prioritise workload pressures, one example of which is the new vaccination programme against human papillomavirus. this paper examines the wider context in which school health care is delivered and proposes a systematic, evidence-based approach that school nurse managers could take toward prioritising tasks. ... | 2009 | 19238818 |
| vulval intraepithelial neoplasia with mucinous differentiation: report of 2 cases of a hitherto undescribed phenomenon. | we report 2 cases of classic vulval intraepithelial neoplasia (vin) with collections of cells throughout the full epithelial thickness and within epithelial downgrowths containing intracytoplasmic mucin. the mucinous cells were bland with eccentrically placed small regular nuclei and were positive with cam5.2, carcinoembryonic antigen, epithelial membrane antigen, and cytokeratin 7, markers that are typically positive in the neoplastic cells of paget disease. both cases were strongly positive wi ... | 2009 | 19238078 |
| comparing knowledge and perceived risk related to the human papilloma virus among australian women of diverse sexual orientations. | the study compared levels of awareness of human papilloma virus (hpv) as a sexually transmissible infection (sti) between women of different sexual orientations. it also examined self-reported risk factors for hpv infection, perceived level of personal risk, and willingness to have the hpv vaccine. | 2009 | 19236366 |
| human papillomavirus (hpv) vaccines: limited cross-protection against additional hpv types. | 2009 | 19236278 | |
| molecular detection and genotyping of human papillomavirus in cervical carcinoma biopsies in an area of high incidence of cancer from moroccan women. | cervical cancer is a leading cause of cancer-related deaths in developing countries, and the human papillomavirus (hpv) is linked etiologically to cervical cancer. eighty nine cervical carcinoma biopsies collected from women visiting the oncologic center in casablanca (centre hospitalier universitaire ibn rochd, morocco) for cervical cancer symptoms, were screened for hpv dna by polymerase chain reaction amplification with subsequent typing by hybridization with specific oligonucleotides for hpv ... | 2009 | 19235879 |
| quantitative human papillomavirus 16 and 18 levels in incident infections and cervical lesion development. | human papillomavirus (hpv) rna levels may be a more sensitive early indicator of predisposition to carcinogenesis than dna levels. we evaluated whether levels of hpv-16 and hpv-18 dna and messenger rna (mrna) in newly detected infections are associated with cervical lesion development. female university students were recruited from 1990 to 2004. cervical samples for hpv dna, hpv mrna, and papanicolaou testing were collected tri-annually, and women were referred for colposcopically directed biops ... | 2009 | 19235870 |
| cervical infections by multiple human papillomavirus (hpv) genotypes: prevalence and impact on the risk of precancerous epithelial lesions. | a large proportion of human papillomavirus (hpv) infections is sustained by multiple genotypes. the effect of multiple infections on the risk of cervical intraepithelial neoplasia (cin) and the potential efficacy of vaccine on these infections are controversial. we performed viral typing by sfp(10)-lipa on a consecutive series of 1,323 women undergoing colposcopy, 69% of whom had cervical biopsy, and correlated cin severity with the type and number of hpvs. overall prevalence of hpv-dna was 68.9 ... | 2009 | 19235847 |
| ifng (+874 t/a) polymorphism and cervical intraepithelial neoplasia in brazilian women. | our objective was to investigate the relationship between ifng (+874 t/a) polymorphism and cervical intraepithelial neoplasia (cin) in a population of brazilian women. ninety-six women, cin ii (48) and cin iii (48) and 50 normal controls, were enrolled in this study. dna was extracted from blood samples by the salting out method and polymerase chain reaction (pcr) amplified. ifng genotyping was performed by the pcr-sequence specific primer method, using the cytokine genotyping tray. there were n ... | 2009 | 19232001 |
| screening for oral cancer. | the incidence of oral cancer appears to be increasing, especially in younger patients. risk factors include use of tobacco and alcohol, and exposure to human papillomavirus. vizilite plus (zila pharmaceuticals) is a combination device that uses fluorescent light and toluidine blue tissue staining to help dentists identify abnormal changes in the mucous membranes of the oral cavity. originally developed for detecting abnormal growths on the uterine cervix, in 2001 it received fda clearance for "i ... | 2009 | 19229163 |
| knowledge and awareness of cervical cancer and screening among malaysian women who have never had a pap smear: a qualitative study. | cervical cancer is one of the commonest cancers in women worldwide. despite the existence of effective screening using pap smear, the uptake of screening is poor. a qualitative study was undertaken using face-to-face in-depth interviews to investigate knowledge, attitudes and beliefs on cervical cancer screening of malaysian women. | 2009 | 19224084 |
| genetic signatures of hpv-related and unrelated oropharyngeal carcinoma and their prognostic implications. | patients with human papillomavirus (hpv)-containing oropharyngeal squamous cell carcinomas (oscc) have a better prognosis than patients with hpv-negative oscc. this may be attributed to different genetic pathways promoting cancer. | 2009 | 19223504 |
| surgical salvage of cancer of the oropharynx after chemoradiation. | advanced oropharyngeal squamous cell carcinoma is treated primarily with chemoradiation, with the goal of excellent disease control and preservation of swallowing and articulation functions of the oropharynx. disease control rates generally are excellent; however, a significant number of patients do not achieve locoregional control of disease. the importance of human papillomavirus expression in predicting successful tumor response, locoregional control, and survival following chemoradiation is ... | 2009 | 19216847 |
| human papillomaviruses and genital co-infections in gynaecological outpatients. | high grade hpv infections and persistence are the strongest risk factors for cervical cancer. nevertheless other genital microorganisms may be involved in the progression of hpv associated lesions. | 2009 | 19216747 |
| cancer prevention by vaccination against hepatitis b. | chronic inflammation caused by persistent infection is closely related to a number of cancers; these include hepatitis b (hbv) or c and hepatoma, human papilloma virus and cervical cancer, and helicobacter pylori and gastric cancer. the first evidence of cancer prevention by vaccination in humans was provided by hbv vaccination in infants. chronic hbv is related to approximately 60%-90% of hepatocellular carcinomas (hcc) in adults and nearly 100% of childhood hcc in areas endemic for hbv infecti ... | 2009 | 19213561 |
| cellular growth inhibition by fk778 is linked to g1 arrest or s phase accumulation, dependent on the functional status of the retinoblastoma protein. | the malononitrilamide fk778 is a novel immunosuppressive agent with antiproliferative activities. to gain insight into the molecular mechanism of fk778-mediated growth inhibition, we analyzed cells which differ in their p53 status and functionality of retinoblastoma protein (prb). fk778 acted as a broad inhibitor of cell proliferation independent of the p53 or prb status. however, the mechanism of fk778-mediated growth inhibition differed, leading either to cell cycle arrest in g1, or cell accum ... | 2009 | 19212661 |
| statbite: prevalence of hpv in a cohort of u.s. men. | 2009 | 19211451 | |
| comparisons of high-risk cervical hpv infections in caribbean and us populations. | disparities in cervical cancer incidence and mortality rates exist among women of african ancestry (african-american, african-caribbean and african). persistent cervical infection with human papillomavirus (hpv) is associated with cervical dysplasia and if untreated, could potentially progress to invasive cervical cancer. very few studies have been conducted to examine the true prevalence of hpv infection in this population. comparisons of cervical hpv infection and the type-specific distributio ... | 2009 | 19208214 |
| high-risk and multiple human papillomavirus (hpv) infections in cancer-free jamaican women. | vaccines, that target human papillomavirus (hpv) high risk genotypes 16 and 18, have recently been developed. this study was aimed at determining genotypes commonly found in high-risk and multiple-hpv infections in jamaican women. two hundred and fifty three (253) women were enrolled in the study. of these, 120 pregnant women, aged 15-44 years, were recruited from the ante natal clinic at the university hospital of the west indies and 116 non-pregnant, aged 19-83, from a family practice in weste ... | 2009 | 19208202 |
| vaginal self-swab specimen collection in a home-based survey of older women: methods and applications. | to describe the methods used for, cooperation with, assays conducted on, and applications of vaginal specimens collected by older women in their homes. | 2009 | 19204072 |
| prophylactic hpv vaccination for women over 18 years of age. | cervical screening has resulted in a major reduction in the incidence and mortality of cervical cancer in the uk and other developed countries. nevertheless approximately 2700 women present with cervical cancer in the uk each year with mortality in excess of 1000 cases. prophylactic hpv vaccination against hpv 16 and 18 has been shown to be highly effective in preventing hpv related malignancy in clinical trials. newly introduced hpv vaccination programmes in the uk and elsewhere are ultimately ... | 2009 | 19200838 |
| an e7-based therapeutic vaccine protects mice against hpv16 associated cancer. | plant-derived vaccines represent an attractive strategy for cancer immunotherapy due to their relative safety and cost-effectiveness. we evaluated the anti-tumour activity of a nicotiana benthamiana produced vaccine candidate based on the non-transforming e7 protein of hpv-16 fused to beta-1,3-1,4-glucanase of clostridium thermocellum. two doses of vaccine at two week intervals were administered to groups of c57bl/6 mice starting 3 or 6 days after challenge with tumourigenic e7-expressing tc-1* ... | 2009 | 19200826 |
| human papillomavirus-associated squamous cell carcinoma of the nail bed in african-american patients. | human papillomavirus (hpv) has been implicated in the development of digital squamous cell carcinoma (scc). case reports in the literature mostly identify hpv type 16 present in tumors, but hpv types 2, 31, 34, 35, and 73 have also been isolated. | 2009 | 19200182 |
| [assessing the incidence of papillomavirus infections in france]. | high-risk oncogenic human papillomavirus (hr-hpv) are strongly associated with squamous cell carcinoma and adenocarcinoma of the uterine cervix. relatively detailed data on prevalence of hr-hpv infections by age in france are available in several cytologically normal women populations but none on incidence. these latter data may be obtained according to the relationship between prevalence and incidence due to the spontaneous viral clearance over time. the study has shown that hr-hpv infections i ... | 2009 | 19196534 |
| [human papillomavirus and cancer of the oropharynx. molecular interaction and clinical implications]. | one-third of the cases of oropharyngeal squamous cell carcinoma (oscc) contain oncogenic human papillomavirus (hr-hpv). epidemiologic and molecular evidence underlines the causal role of hr-hpv in these tumors, which can be defined as hpv-related oscc. these tumors differ from chemical/toxin-induced oscc in several biological aspects, including specific molecular and genetic alterations. this leads to a characteristic clinical profile of hpv-related oscc. sexual risk factors play a role; however ... | 2009 | 19194683 |
| disparities in how parents are learning about the human papillomavirus vaccine. | differential access to basic health information may contribute to persistent cervical cancer disparities. we examined whether human papillomavirus (hpv) vaccine awareness, hpv knowledge, and use of information sources about the vaccine differ by sociodemographic characteristics associated with cervical cancer. | 2009 | 19190161 |
| human papillomavirus type distribution in anal cancer and anal intraepithelial lesions. | a systematic review was conducted of hpv type distribution in anal cancer and anal high-grade and low-grade squamous intraepithelial lesions (hsil and lsil). a medline search of studies using pcr or hybrid capture for hpv dna detection was completed. a total of 1,824 cases were included: 992 invasive anal cancers, 472 hsil cases and 360 lsil cases. crude hpv prevalence in anal cancer, hsil, and lsil was 71, 91 and 88%, respectively. hpv16/18 prevalence was 72% in invasive anal cancer, 69% in hsi ... | 2009 | 19189402 |
| genetic variants in tap are associated with high-grade cervical neoplasia. | the transporter associated with antigen processing (tap) is essential in assembling mhc-i proteins. human papillomavirus (hpv) evades immune recognition by decreasing class i mhc cell surface expression through down-regulation of tap1 levels. consistent with heterogeneity in mhc expression is the individual variability in clearing detectable hpv infections. genetic polymorphisms in tap genes may affect protein structure, function, and the ability to clear hpv infection. | 2009 | 19188174 |
| ensembled support vector machines for human papillomavirus risk type prediction from protein secondary structures. | infection by the human papillomavirus (hpv) is regarded as the major risk factor in the development of cervical cancer. detection of high-risk hpv is important for understanding its oncogenic mechanisms and for developing novel clinical tools for its diagnosis, treatment, and prevention. several methods are available to predict the risk types for hpv protein sequences. nevertheless, no tools can achieve a universally good performance for all domains, including hpv and nor do they provide confide ... | 2009 | 19185855 |
| immortalization of normal human gingival keratinocytes and cytological and cytogenetic characterization of the cells. | most in vitro studies of oral carcinogenesis in human cells are carried out with oral keratinocytes immortalized by human papillomavirus type 16 dna. however, because various etiological factors for oral cancer are known, it is important to establish new human keratinocyte cell lines useful for studying the mechanism of oral carcinogenesis. normal human gingival keratinocytes in secondary cultures grown in serum-free medium were either transfected with origin (-) sv40 dna or sequentially transfe ... | 2009 | 19184294 |
| multiple human papillomavirus infection and high grade cervical intraepithelial neoplasia among women with cytological diagnosis of atypical squamous cells of undetermined significance or low grade squamous intraepithelial lesions. | to evaluate the effect of multiple human papillomavirus (hpv) infection on the prevalence of cervical intraepithelial neoplasia (cin) among women undergoing colposcopy following a cytological diagnosis of atypical squamous cells of undetermined significance (ascus) or low grade squamous intraepithelial lesions (lsil). | 2009 | 19181368 |
| epithelial expression of human papillomavirus type 16 e7 protein results in peripheral cd8 t-cell suppression mediated by cd4+cd25+ t cells. | the role of thymic versus peripheral epithelium in the regulation of the antigen-specific cd8 t-cell repertoire is still largely unresolved. we generated tcr-beta chain transgenic mice in which an increased frequency of peripheral cd8 t cells recognizes an epitope from a viral oncoprotein (hpv16e7) in the context of h-2d(b) mhc class i. when t cells from these mice developed through the thymus of mice expressing functional e7 protein from a keratin 14 promoter, no major perturbation to transgeni ... | 2009 | 19180468 |
| [advancements in diagnosis of sexually transmitted diseases in urology]. | sexually transmitted diseases diagnosed and treated exclusively in urology clinics are male urethritis and epididymitis caused by neisseria gonorrhoeae and chlamydia trachomatis. although recent developments in diagnostic tools have made it possible to detect these microorganisms with extremely high sensitivities, the screening of neisseria gonorrhoeae using the microscopic observation of intraleucocyte diplococci stained by methylene blue or gram staining in the first voided urine sediment or u ... | 2009 | 19177755 |
| [mechanisms of high-risk human papillomavirus-induced cervical carcinogenesis]. | human papillomaviruses (hpvs) are believed to be the primary causal agents for development of pre-neoplastic and malignant lesions of the uterine cervix and high-risk types such as type 16 and 18 are associated with more than 90% of all cervical carcinomas. the e6 and e7 genes of hpvs are thought to play causative roles, since e6 promotes the degradation of p53 through its interaction with e6ap, an e3 ubiquitin ligase, whereas e7 binds to the retinoblastoma protein prb and disrupts its complex f ... | 2009 | 19177752 |
| prognostic value of measuring load of human papillomavirus dna in cervical samples: an elusive target. | 2009 | 19176455 | |
| a bayesian framework for estimating vaccine efficacy per infectious contact. | in vaccine studies for infectious diseases such as human immunodeficiency virus (hiv), the frequency and type of contacts between study participants and infectious sources are among the most informative risk factors, but are often not adequately adjusted for in standard analyses. such adjustment can improve the assessment of vaccine efficacy as well as the assessment of risk factors. it can be attained by modeling transmission per contact with infectious sources. however, information about conta ... | 2008 | 19169384 |
| triage of women with equivocal or low-grade cervical cytology results: a meta-analysis of the hpv test positivity rate. | consistent evidence underlines the utility of human papillomavirus (hpv) dna testing in the management of women with equivocal cervical cytological abnormalities, but not in case of low-grade lesions. we performed a meta-analysis including studies where the high-risk probe of the hybrid capture-ii is used to triage these two cytological categories. the triage test-positivity rate reflects the colposcopy referral workload.data were pooled on the hpv test positivity rate in women with atypical squ ... | 2009 | 19166485 |
| the bcl-xl inhibitor of apoptosis is preferentially expressed in cutaneous squamous cell carcinoma compared with that in keratoacanthoma. | keratoacanthoma (ka) is difficult to histologically distinguish from squamous cell carcinoma (scc). therefore, although ka is a benign self-resolving skin lesion, ka is commonly treated as scc. biomarkers to distinguish ka and scc would thus be desirable. in search for specific markers, paraffin-embedded tissue samples from 25 scc and 64 ka were arranged in a tissue microarray (tma) and stained for immunologic cell-markers cd3, cd20 and cd68 as well as for proteins considered of relevance in tum ... | 2009 | 19165861 |
| induction of focal epithelial hyperplasia in tongue of young bk6-e6/e7 hpv16 transgenic mice. | squamous cell carcinoma (scc) of the oral cavity is one of the most common neoplasms in the world. during the past 2 decades, the role of high-risk human papilloma virus (hr-hpv) has been studied and the data supporting hpv as a one of the causative agents in the development and progression of a sub-set of head and neck squamous cell carcinomas (hnscc) has accumulated. in order to investigate the role of hr-hpv oncogene expression in early epithelial alterations in vivo, we produced transgenic m ... | 2009 | 19165615 |
| a type-specific study of human papillomavirus prevalence in cervicovaginal samples in three different spanish regions. | human papillomavirus (hpv) is the most frequent sexually transmitted viral infection. it is necessary to know hpv genotype distribution to identify how many women will be protected by hpv vaccines. during a period of 18 months, we have analyzed 2362 hpv positive reporting data from a secondary demand screening program in three regions in spain (cantabria, leon and burgos). the study has been conducted using polymerase chain reaction and tube array hybridization covering the 35 hpv genotypes desc ... | 2009 | 19161533 |
| characterization of immortalized human epidermolysis bullosa simplex (krt5) cell lines: trimethylamine n-oxide protects the keratin cytoskeleton against disruptive stress condition. | epidermolysis bullosa simplex (ebs) is an autosomal inherited mechano-bullous disease, characterized by intraepidermal blistering and skin fragility caused by mutations in the keratin (krt) 5 or 14 genes. despite a vast knowledge about the intermediate filament pathology in this disease, the progress in therapy has been slow. animal models and well-characterized continuous cell culture models of ebs are needed prior to clinical testing. | 2009 | 19157792 |
| a strained dna binding helix is conserved for site recognition, folding nucleation, and conformational modulation. | nucleic acid recognition is often mediated by alpha-helices or disordered regions that fold into alpha-helix on binding. a peptide bearing the dna recognition helix of hpv16 e2 displays type ii polyproline (pii) structure as judged by ph, temperature, and solvent effects on the cd spectra. nmr experiments indicate that the canonical alpha-helix is stabilized at the n-terminus, while the pii forms at the c-terminus half of the peptide. re-examination of the dihedral angles of the dna binding heli ... | 2009 | 19156829 |
| gene expression patterns induced by hpv-16 l1 virus-like particles in leukocytes from vaccine recipients. | human papillomavirus (hpv) virus-like particle (vlp) vaccines were recently licensed. although neutralizing ab titers are thought to be the main effectors of protection against infection, early predictors of long-term efficacy are not yet defined and a comprehensive understanding of innate and adaptive immune responses to vaccination is still lacking. here, microarrays were used to compare the gene expression signature in hpv-16 l1 vlp-stimulated pbmcs from 17 vaccine and 4 placebo recipients be ... | 2009 | 19155521 |
| high-risk hpv types in lesions of the uterine cervix of female commercial sex workers in the philippines. | in order to prevent cervical cancer, vaccines against human papilloma virus types 16 (hpv-16) and 18 (hpv-18) have been implemented worldwide. however, the hpv types that cause cancer can differ according to geographical area and ethnicity. in this new era of the hpv vaccine, it is important to elucidate the prevalent hpv types in each area. therefore, the prevalence of hpv infection and cervical abnormalities among 369 female commercial sex workers in the philippines were examined. hpv l1 gene ... | 2009 | 19152419 |
| interaction between human papillomavirus type 5 e2 and polo-like kinase 1. | the e2 protein of the papillomavirus plays an essential role in the viral life cycle. through a yeast two-hybrid screening, human polo-like kinase 1 was found to interact with human papillomavirus type 5 e2. further characterization identified that the domains responsible for the interaction are the transactivation domain of hpv-5 e2 and the sequence between the kinase and the polo box domains of plk1. in vivo, plk1 and hpv-5 e2 are colocalized at the nuclear speckles. in the skin epithelium not ... | 2009 | 19152411 |
| the catch up program for human papillomavirus vaccine. | 2008 | 19149027 | |
| anticancer effects on tacc3 by treatment of paclitaxel in hpv-18 positive cervical carcinoma cells. | previously, we used proteome analysis to identify transforming acidic coiled coil (tacc) 3 as a protein that is down-regulated upon paclitaxel treatment in cervical cancer cells. tacc3 mrna and protein levels decreased after paclitaxel treatment in a time- and dose-dependent manner, and the transactivation of tacc3 promoter was dramatically diminished by paclitaxel. importantly, paclitaxel treatment and knockdown of tacc3 by sirna led to a synergistic enhancement of significant g2/m phase arrest ... | 2009 | 19148534 |
| chromosomal signatures of a subset of high-grade premalignant cervical lesions closely resemble invasive carcinomas. | cervical cancer develops from precancerous high-grade cervical intraepithelial neoplasia (cin) harboring a transforming infection with high-risk human papillomavirus, which is characterized by p16(ink4a) overexpression. once such a lesion has developed, progression toward an invasive squamous cell carcinoma (scc) may take one or more decades, underlining the heterogeneity of these lesions in terms of duration of existence and progression risk. we performed array-based comparative genomic hybridi ... | 2009 | 19147580 |
| prevalence of human papillomavirus genotypes in women from a rural region of puebla, mexico. | to determine the prevalence of human papillomavirus (hpv) genotypes 6, 11, 16, 18, and 31 in mexican women living in rural areas of puebla, mexico and to evaluate risk factors associated with cervical neoplasm in this population. | 2009 | 19147384 |
| molecular hpv typing as a diagnostic tool to discriminate primary from metastatic squamous cell carcinoma of the lung. | in this study, typing of human papilloma virus (hpv) was performed in squamous cell carcinomas of the lung (n=26) as well as putative primaries of head and neck (n=21) and female genital tract (n=5) of the same patients, to test whether additional information to discriminate lung primaries from metastases can be gained by a direct comparison of the hpv status in both tumors. in 3 (14.2%) patients with head and neck as well as lung squamous cell carcinoma, an identical hpv subtype could be detect ... | 2009 | 19145203 |
| asymmetric gp5+/6+ pcr and hybridization with fluorescence polarization assay of 15 human papillomavirus genotypes in clinical samples. | the detection of a broad spectrum of hpv genotypes has not been used widely in cervical cancer screening due to technical difficulties and high costs. | 2009 | 19144564 |
| [epidermoid anal carcinoma]. | epidermoid carcinoma of the anus is a rare cancer, and conventionally affects elderly women. its incidence is on the increase, at a younger age of onset, particularly within the male homosexual population. main predisposing factors are sexually transmitted diseases and particularly human papillomavirus (hpv) infection, variety of sexual partners, smoking, homosexuality, history of uterine cervix cancer, and immunodepression. warning signs of anal cancer are often non-specific. therefore any atyp ... | 2008 | 19143150 |
| enhancement of dendritic cell-based vaccine potency by anti-apoptotic sirnas targeting key pro-apoptotic proteins in cytotoxic cd8(+) t cell-mediated cell death. | dendritic cells (dcs) have become an important measure for the treatment of malignancies. current dc preparations, however, generate short-lived dcs because they are subject to cell death from various apoptotic pressures. antigen-specific cd8(+) cytotoxic t lymphocytes (ctls) is one of the main obstacles to limit the dc-mediated immune priming since ctls can recognize the target antigen expressing dcs as target cells and kill the dcs. ctls secret perforin and serine protease granzymes during ctl ... | 2009 | 19135479 |
| palliative aspects of recurrent respiratory papillomatosis. | recurrent respiratory papillomatosis (rrp) is a chronic, frequently debilitating, and potentially life-threatening disease. therapy for rrp has evolved from simply inserting a tracheotomy to provide an airway and plucking out papillomata with cup forceps to provide some degree of voice to the present-day far more sophisticated approaches, along with preventative measures that may someday offer the potential dramatically to decrease disease prevalence. family dynamics and support and intentional ... | 2009 | 19134490 |
| expression of human papilloma virus type 16 e5 protein in amelanotic melanoma cells regulates endo-cellular ph and restores tyrosinase activity. | melanin synthesis, the elective trait of melanocytes, is regulated by tyrosinase activity. in tyrosinase-positive amelanotic melanomas this rate limiting enzyme is inactive because of acidic endo-melanosomal ph. the e5 oncogene of the human papillomavirus type 16 is a small transmembrane protein with a weak transforming activity and a role during the early steps of viral infections. e5 has been shown to interact with 16 kda subunit c of the trans-membrane vacuolar atpase proton pump ultimately r ... | 2009 | 19133143 |
| single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous sccs. | cutaneous squamous cell carcinomas (csccs) are the second most frequent cancers in fair-skinned populations; yet, because of their genetic heterogeneity, the key molecular events in cscc tumorigenesis remain poorly defined. we have used single nucleotide polymorphism microarray analysis to examine genome-wide allelic imbalance in 60 csccs using paired non-tumor samples. the most frequent recurrent aberrations were loss of heterozygosity at 3p and 9p, observed in 39 (65%) and 45 (75%) tumors, res ... | 2009 | 19131950 |
| epidemiological data of different human papillomavirus genotypes in cervical specimens of hiv-1-infected women without history of cervical pathology. | to study the epidemiology of different human papillomavirus (hpv) genotypes in cervical samples of hiv-1-infected women with normal papanicolau smears. | 2009 | 19131892 |
| human papillomavirus--lessons from history and challenges for the future. | human papillomavirus (hpv) is the most common sexually transmitted infection, and hpv-associated cervical cancer is a significant cause of morbidity and mortality worldwide. recent advances in molecular biology have facilitated testing for hpv infection. over the last decade, national and international cervical cancer screening programs have added hpv testing to their guidelines. the use of hpv prophylactic and therapeutic immunization may expand the need for systematic hpv testing to help defin ... | 2008 | 19126284 |
| an hpv 16 l1-based chimeric human papilloma virus-like particles containing a string of epitopes produced in plants is able to elicit humoral and cytotoxic t-cell activity in mice. | even though two prophylactic vaccines against hpv are currently licensed, infections by the virus continue to be a major health problem mainly in developing countries. the cost of the vaccines limits wide-scale application in poor countries. a promising strategy for producing affordable and efficient vaccines involves the expression of recombinant immunogens in plants. several hpv genes have been expressed in plants, including l1, which can self-assemble into virus-like particles. a plant-based, ... | 2009 | 19126233 |
| detection of human papillomavirus dna in retinoblastoma samples: a preliminary study. | recent studies have shown the presence of human papillomavirus (hpv) genome in retinoblastoma (rb) tumor samples. there is no information on the hpv status in the rb tumors of indian patients. we studied the presence of hpv genome in rb tumor samples from patients with unilateral tumor. forty-four fresh rb tumor samples and 30 non-neoplastic donor retinas were analyzed for the presence of hpv 16 and 18 genome by nested and seminested polymerase chain reaction. tumor tissue sections were also use ... | 2009 | 19125079 |
| variables associated with human papillomavirus (hpv) vaccine acceptance by men. | to determine correlates of human papillomavirus (hpv) vaccine acceptance for men. | 2009 | 19124631 |
| prevaccination distribution of human papillomavirus types in women attending at cervical cancer screening in belgium. | before the introduction of vaccination against human papillomaviruses (hpv) as a new strategy of combating cervical cancer, it is required to describe the baseline prevalence of hpv infection as well as the distribution of the different hpv types in the population and among women with cervical lesions. | 2009 | 19124515 |
| antibody response for l1, e6, e7 hpv 16, and hpv 18 antigens in tunisian women with cervical cancer. | results obtained in the present work indicated that the luminex assay is more sensitive than elisa. the reactivity to the early antigens e6 and e7 was 37% versus 42% for hpv 16 and 21% versus 20% for hpv 18 among cervical cancer cases using elisa. however, these ratios were 44% and 61%, respectively, for e6 and e7 hpv 16 versus 28% and 21% for e6 and e7 hpv 18 when using the luminex technique. data also indicated that hpv 16 and hpv 18 showed distinct profiles for the different antigens tested. ... | 2009 | 19117204 |
| prevalence of human papillomavirus types 6, 11, 16 and 18 in young austrian women - baseline data of a phase iii vaccine trial. | cervical cancer is the second most common cancer among women worldwide. in the absence of changing risk or intervention, it is projected that in comparison with 2002 there will be a 40% increase in the number of new cases of cervical cancer by 2020. hpv types 16 and 18 cause 70% of cervical cancers worldwide, 50% of high-grade cervical intraepithelial neoplasias and 25% of low-grade neoplasias. hpv types 6 and 11 are the causative agent of > 90% of genital warts. the aim of this study was to ass ... | 2008 | 19116707 |
| sequence variation of human papillomavirus type 16 and measurement of viral integration by quantitative pcr. | given that the integration of human papillomavirus type 16 (hpv16) into the host genome occurs preferentially with the disruption of the e2 gene, a ratio of e2 to e7 gene copies is often used as a marker for integration. it is largely undetermined, however, whether ratio estimates are affected by hpv intratypic variations. we assembled four plasmid constructs, each containing a dna fragment from an hpv16 european, asian-american, african-1, or african-2 variant. these constructs and nine cervica ... | 2009 | 19116350 |
| tax1bp1 interacts with papillomavirus e2 and regulates e2-dependent transcription and stability. | the papillomavirus e2 proteins regulate viral replication, gene transcription, and genome maintenance by interacting with other viral and host proteins. from a yeast two-hybrid screen, we identified the cellular protein tax1bp1 as a novel binding partner of human papillomavirus type 18 (hpv18) e2. tax1bp1 also interacts with the hpv16 and bovine papillomavirus type 1 (bpv1) e2 proteins, with the c-terminal region of tax1bp1 interacting with the n-terminal transactivation domain of bpv1 e2. tax1b ... | 2009 | 19109394 |
| genomic diversity of human papillomavirus (hpv) genotype 38. | human papillomavirus (hpv) genotype hpv 38 is a hpv genotype associated with skin cancer and is classified taxonomically in the beta-pv genus-species 2. at least six genomic variants of hpv 38, including prototype isolate and its subtype fa125, have been characterized so far. in order to investigate further the genomic diversity of hpv 38, a total of 39 hpv 38 positive samples obtained from hairs plucked from pubic, scrotal, perianal or eyebrow regions from 31 immunocompetent healthy male indivi ... | 2009 | 19107968 |
| typing of human papillomavirus in women with cervical lesions: prevalence and distribution of different genotypes. | human papillomavirus (hpv) are distributed widely and persistent infection with high-risk (hr) hpv is recognized as a necessary cause of cervical cancer. the aim of this study was to evaluate the distribution of different hr-hpv genotypes in 199 women with cervical pre-invasive lesions undergoing conservative treatment. a linear array hpv genotyping test was used to identify individual hpv genotypes in cervical samples. it was observed that the most prevalent hpv genotypes were hpv 16 (52.6%), h ... | 2009 | 19107962 |
| determinants of incidence of primary fallopian tube carcinoma (pftc). | primary fallopian tube carcinoma (pftc) is a rare malignancy, but its incidence has been rising during the last decades and varies between 2.9/1,000,000 and 5.7/1,000,000. the epidemiology of pftc has been sparsely studied. in finland, the incidence rate has been rising during the last decades. the rise has been highest in the cities, in higher social classes, and in certain specific occupations. parity gives protection against this disease, as does a previous sterilization procedure. earlier th ... | 2009 | 19107444 |
| enhancement of immunotherapeutic effects of hpv16e7 on cervical cancer by fusion with ctla4 extracellular region. | cervical cancer is caused by infection by high-risk human papillomavirus (hpv), especially hpv16. limitations in current treatments of cervical cancers call for the development of new and improved immunotherapies. this study aims at investigating the efficacy of a novel vaccine consisting of modified hpv 16e7 fused with human cytotoxic t-lymphocyte antigen 4 (ctla4). the regions in hpv16 e7 gene associated with its transformation and ctl-enhanced response were modified; the resultant hpv16me7 wa ... | 2008 | 19107404 |
| [significance of human papillomavirus test in triage of patients with atypical squamous cell of undetermined significance]. | to investigate the significance of human papillomavirus test in triage of patients with atypical squamous cell of undetermined significance (ascus) diagnosed by cervical cytology. | 2008 | 19105350 |
| immunogenicity and safety of human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine in healthy boys aged 10-18 years. | the human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine (cervarix) has been shown to be well-tolerated and immunogenic in females aged 10 to 55 years, and up to 100% effective for the prevention of hpv-16/18 infection and associated precancerous cervical lesions in females aged 15 to 25 years. this study is the first to evaluate the immunogenicity and safety of the vaccine in males. | 2009 | 19101456 |
| access of black, hispanic, and nonprivately insured women to liquid-based cytology, human papillomavirus dna testing, and on-site colposcopy in the united states. | to determine whether patient race, ethnicity, or insurance status was associated with access to cervical cancer screening with liquid-based cytology (lbc) and with human papillomavirus (hpv) dna testing and with access to on-site colposcopy at the provider's principal practice site. | 2009 | 19098602 |
| [etiology and pathogenesis of precancerous lesions and invasive cervical carcinoma]. | cervical cancer is the second most common gynecological malignancy in the world. human papilloma virus (hpv) infection is the leading ethiologic agent in the development of premalignant and malignant cervical diseases. hpv is a member of the papovaviridae family and until now over 100 types have been recognized there are two types of viral infection: latent and productive. virus induced oncogenesis is the result of interaction between virus oncoproteins e6 and e7 and tumor supresor host genes p5 ... | 2008 | 19097373 |
| expression pattern and subcellular localization of human papillomavirus minor capsid protein l2. | the expression pattern of human papillomavirus (hpv) capsid antigen l2 is poorly described, and the significance of its localization with both promyelocytic leukemia protein (pml) and daxx in a subnuclear domain, nuclear domain 10 (nd-10), when ectopically expressed in tissue culture cells is controversial. to address whether nd-10 localization of l2 occurs in natural cervical lesions, we used a hpv16 and hpv18 l2-specific monoclonal antibody (rg-1), in addition to rabbit antiserum to hpv6 l2, t ... | 2009 | 19095951 |
| [expression of skp2 in cervical squamous cell carcinoma and precancerous lesions and its correlation with hpv16/18 infection]. | to study the expression of skp2 in cervical squamous cell carcinoma (scc) and its precancerous lesions, and to investigate its relationship with human papillomavirus (hpv) infection. | 2008 | 19094580 |
| implementing a school-based hpv vaccination programme. | the department of health launched a national human papillomavirus immunisation programme for girls aged 12-13 years in september 2008. | 2008 | 19090363 |
| diminished ifn-gamma and il-10 and elevated foxp3 mrna expression in the cervix are associated with cin 2 or 3. | cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (hpv) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (cin). additionally, regulatory t (treg) cells are increasingly understood to be important modulators of cellular immunity. using quantitative rt-pcr, we measured, in cross-sectional design, the cervical mrna expression of ifn-gamma, il-10, and il-12, as ... | 2009 | 19089920 |
| human papillomavirus 6 seropositivity is associated with risk of head and neck squamous cell carcinoma, independent of tobacco and alcohol use. | the risk of head and neck squamous cell carcinoma (hnscc) associated with common human papillomavirus types has not been well defined. | 2009 | 19087986 |
| the role of male circumcision in the prevention of human papillomavirus and hiv infection. | 2009 | 19086812 | |
| identification of human papillomavirus in esophageal squamous papillomas. | to investigate the presence of human papillomavirus (hpv) in esophageal squamous papilloma (esp) and determine p16, p53 and ki67 expression in a mexican cohort. | 2008 | 19084918 |
| the pro-angiogenic factors stimulated by human papillomavirus type 16 e6 and e7 protein in c33a and human fibroblasts. | to investigate the pro-angiogenic factors stimulated by human papillomavirus type 16 e6 and e7 protein in c33a and human fibroblasts. hpv-16 e6 and e7 genes were transfected into c33a and hfb to detect the profiling of angiogenesis-associated factors with the transignal angiogenesis antibody array. the mrna and protein levels of the cytokines were examined by traditional rt-pcr and western blotting in both cell lines before and after transfection of hpv-16 e6 and e7. hpv-16 e6 and e7 genes were ... | 2009 | 19082439 |
| the common mechanisms of transformation by the small dna tumor viruses: the inactivation of tumor suppressor gene products: p53. | the small dna tumor viruses, polyoma virus, simian vacuolating virus 40, the papilloma viruses and the human adenoviruses, were first described during a period of intense virus discovery (1930-1960s) and shown to produce tumors in animals. in each of these cases the viral dna was shown to persist (commonly integrated into a host chromosome) and only a selected portion of this dna was expressed as m-rna and proteins in these cancers. the viral encoded tumor antigens were identified and shown to b ... | 2009 | 19081592 |
| prevalence of human papillomavirus and chlamydia trachomatis infection among women attending cervical cancer screening in the republic of korea. | cervical cancer screening with the conventional papanicolaou test is recommended for the women aged 30 years and more in korea. cervical infection with human papillomavirus (hpv) is the most important cause of cervical cancer and chlamydia trachomatis (ct) is the most common bacterial sexually transmitted infection and may also be associated with risk of cervical cancer. a cross-sectional study of women attending the national cervical cancer screening program in busan and suwon was carried out. ... | 2009 | 19077566 |
| systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy. | locally produced transforming growth factor-beta (tgf-beta) promotes tumor-induced immunosuppression and contributes to resistance to immunotherapy. this article explores the potential for increased efficacy when combining immunotherapies with tgf-beta suppression using the tgf-beta type i receptor kinase inhibitor sm16. adenovirus expressing ifn-beta (ad.ifn-beta) was injected intratumorally once in established s.c. ab12 (mesothelioma) and lkr (lung cancer) tumors or intratracheally in a kras o ... | 2008 | 19074893 |
| cervical cancer screening with liquid cytology in women with developmental disabilities. | to evaluate the use of liquid cytology in pap smears in women with developmental disabilities (dd) for endocervical cell yield and abnormalities, via speculum examination or blind technique. | 2009 | 19072727 |