Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| aids and the lung. introduction. | damage to the immune system induced by the human immunodeficiency virus (hiv) leads to a spectrum of opportunistic infections of which the lung is the most common site. in europe and north america, pneumocystis carinii pneumonia is the presenting symptom in 64% of cases of acquired immunodeficiency syndrome (aids) and occurs at some point in 80% of aids victims. this infection is less common in africa, where tuberculosis is the predominant opportunistic infection. other aids-related lung infe ... | 1989 | 2595618 |
| kaposi's sarcoma in a homosexual--10 years on. | kaposi's sarcoma is seen in one of several clinical settings. before the recognition of the acquired immune deficiency syndrome (aids) in the early 1980s, the most frequent presentation of kaposi's sarcoma in the uk was the so-called 'classical' form of the disease. the most common form of kaposi's sarcoma in this country is now that associated with aids, which particularly affects young male homosexuals. here we describe a homosexual man who has developed many kaposi's sarcoma tumours during th ... | 1989 | 2591081 |
| aids-associated kaposi's sarcoma: a molecular model for its pathogenesis. | kaposi's sarcoma is a mesenchymal tumor that is frequently observed in aids patients. although the tumor is clearly associated with hiv-1 infection, little is known about the molecular events underlying its pathogenesis. here we consider the potential roles of specific cytokines and the virally encoded tat product in inducing the tumor. | 1989 | 2561910 |
| diagnosis of pulmonary disease in human immunodeficiency virus infection: role of transbronchial biopsy and bronchoalveolar lavage. | the value of transbronchial biopsy and bronchoalveolar lavage was assessed in the diagnosis of pulmonary disease in patients infected with the human immunodeficiency virus (hiv). seventy four transbronchial biopsy and 66 bronchoalveolar lavage specimens (60 paired specimens) from 80 examinations in 64 patients were reviewed. pneumocystis carinii was the most common pathogen isolated (43 patients). bronchoalveolar lavage was superior to transbronchial biopsy for the diagnosis of this pathogen, th ... | 1989 | 2549653 |
| ocular manifestations of acquired immune deficiency syndrome. | the ocular complications of acquired immune deficiency syndrome (aids) include: (1) a noninfectious microangiopathy, most often seen in the retina, consisting of cotton-wool spots with or without intraretinal hemorrhages and other microvascular abnormalities; (2) opportunistic ocular infections, primarily cytomegalovirus (cmv) retinitis; (3) conjunctival, eyelid, or orbital involvement by those neoplasms seen in patients with aids (i.e., kaposi's sarcoma and lymphoma); and (4) neuro-ophthalmic l ... | 1989 | 2549483 |
| oral manifestations of hiv infection in 75 dutch patients. | seventy-five consecutive hiv-infected patients, including 33 aids cases were examined. one or more oral mucosal lesions were observed in 57 (76%); candidiasis was the most common finding (52%). others included hairy leukoplakia (16%), periodontal disease (16%) and kaposi's sarcoma (4%). diversity of study design and methods allowed no reliable comparison with other reports. | 1989 | 2545871 |
| cells derived from sporadic and aids-related kaposi's sarcoma reveal identical cytochemical and molecular properties in vitro. | we have established 40 cell cultures from biopsies of 5 patients with sporadic kaposi's sarcoma (ks) and compared them with cell cultures derived from ks biopsies of aids patients. immunocytochemical staining of sporadic ks cells revealed the same endothelial cell markers as those expressed on aids-ks cells, indicating that both types of ks might be of endothelial cell origin. in contrast to clinical features, in vitro growth properties showed no differences. ks cells of both types reveal a low ... | 1989 | 2543647 |
| non-cryptosporidial diarrhoea in human immunodeficiency virus (hiv) infected patients. | thirty of 81 consecutive hiv antibody positive patients referred with non-cryptosporidial diarrhoea had no potential infectious cause; most had aids related complex rather than the full blown syndrome. opportunistic infections with cytomegalovirus (cmv), mycobacterium avium-intracellulare (mai), and herpes simplex virus (hsv), which allowed a diagnosis of aids to be made, were found in 19 patients and were the presenting features of aids in five. other potential pathogenic species included entam ... | 1989 | 2539310 |
| recovery of human immunodeficiency virus and detection of p24 antigen in bronchoalveolar lavage fluid from adult patients with aids. | published reports indicate that hiv is recovered from bal fluid of patients with aids who have lip but not with other aids-related pulmonary disease. our experience has been different. ten bal specimens from nine patients with aids were cultured directly in peripheral blood mononuclear cells, and all ten cultures were positive for hiv as indicated by examination of the culture supernatant by reverse transcriptase assay and enzyme immunoassay for hiv antigen. five of the specimens were also posit ... | 1989 | 2500312 |
| immunohistopathology of lymph nodes in htlv-iii infected homosexuals with persistent adenopathy or aids. | lymph node biopsies from 43 male homosexuals with persistent generalized lymphadenopathy and from ten acquired immunodeficiency syndrome patients, all with serum antibodies to human t-cell leukemia virus iii, were studied with regard to histopathology, immunohistology, and t-cell subsets in cell suspensions. all acquired immunodeficiency syndrome biopsies except one with kaposi's sarcoma had the same histopathological pattern of follicular depletion, whereas the persistent generalized lymphadeno ... | 1985 | 2410110 |
| approaches to interferon combination therapy in the treatment of aids. | high-dose interferon alfa (ifn alfa) therapy induces an overall response rate of 25% to 30% in unselected patients with acquired immunodeficiency syndrome (aids)-related kaposi's sarcoma. up to 50% of patients with relatively preserved immune reactivity respond to treatment. however, when dosages of 20 x 10(6) units or more per day are used to induce responses, constitutional and hematologic side effects may be significant. therefore, efforts are being made to lower the effective dose of ifn alf ... | 1990 | 2405490 |
| infection of the heart by the human immunodeficiency virus. | heart muscle disease in the acquired immune deficiency syndrome (aids), characterized by electrocardiographic changes or congestive cardiomyopathy, is a documented clinical problem, but its pathogenesis is obscure. in aids the heart is known to be involved by a variety of opportunistic infections as well as kaposi's sarcoma, but no causative relation with the development of cardiomyopathy has been established. this study reports evidence for direct infection of the heart in aids, not by an oppor ... | 1990 | 2371952 |
| upper airway obstruction due to tonsillar lymphadenopathy in human immunodeficiency virus infection. | head and neck manifestations of human immunodeficiency virus (hiv) infection are common and include diffuse cervical lymphadenopathy, cutaneous and mucosal kaposi's sarcoma, mucosal herpes simplex infection, upper aerodigestivetractcandidiasis, and parotidlymphadenopathy and cysts. recurrent otitis media and chronic sinusitis have been noted in the pediatric hiv population. we describe a patient with hiv-associated tonsillar and adenoid lymphadenopathy and upper airway obstruction. pathologic an ... | 1990 | 2340129 |
| therapeutic approaches to neoplasms in aids. | the multifactorial etiology of kaposi's sarcoma (ks), which is seen primarily in men, includes genetic predisposition and immunosuppression. recently, the ks seen in association with human immunodeficiency virus (hiv) infection has been shown to be mediated by the production of certain growth factors. hiv per se may also play an etiologic role via its tat gene. therapeutic options include irradiation for local or cosmetic control, interferon-alpha, combinations of antiretroviral agents and inter ... | 1990 | 2237135 |
| kaposi's sarcoma: a light and electron microscopic study. | a patient with diabetes mellitus who developed the typical classic lesions of kaposi's sarcoma is described. our patient presented with a reddish-purple papulonodular lesion on the right foot of five months' duration. a skin biopsy specimen showed a proliferation of spindle cells forming numerous vascular slits and a diffuse extravasation of erythrocytes. the patient's sera was negative for human immunodeficiency virus (hiv) antibodies and cytomegalovirus (cmv) antibodies. ultrastructural examin ... | 1990 | 2229644 |
| kaposi's sarcoma and aids. | 1990 | 2202906 | |
| cutaneous manifestations of hiv infection other than kaposi's sarcoma: clinical and histologic aspects. | the skin is commonly affected in patients with human immunodeficiency virus (hiv) infection. viral, bacterial, fungal, and protozoal infections and ectoparasitic infestations may affect the skin primarily or secondarily in this patient population. in addition, common inflammatory dermatoses may be severe and persistent. furthermore, unusual inflammatory conditions not commonly seen in immunocompetent patients may occur. the more common opportunistic infectious diseases, as well as some of the in ... | 1990 | 2193955 |
| human immunodeficiency virus infection in women: report of 102 cases. | we examined surgical specimens from 19 human immunodeficiency virus (hiv) seropositive females and 83 females with acquired immunodeficiency syndrome (aids) to determine (a) frequency of opportunistic infections (oi) and malignancies, (b) differences or similarities between different risk groups, and (c) differences or similarities when compared with men having aids. a risk factor was identified in 86 patients (72 aids and 14 hiv seropositive), of whom the majority were intravenous drug abusers ... | 1990 | 2172959 |
| opportunistic agents in bronchoalveolar lavage in 99 hiv seropositive patients. | during a ten month period, 117 fibreoptic bronchoscopies and bronchoalveolar lavages (bal) were performed in human immunodeficiency virus (hiv) infected patients suspected of having opportunistic pulmonary infections. the bal were classified into 3 groups, according to clinical manifestations related to hiv infection at the time of fibreoptic bronchoscopy: pre-acquired immunodeficiency syndrome (aids) (n = 54), aids with kaposi's sarcoma (n = 37), aids without kaposi's sarcoma (n = 26). on chest ... | 1990 | 2160374 |
| prognostic significance of quantitative levels of hiv p24 binding capacity in hiv infection. | human immunodeficiency virus, type 1 (hiv-1), produces a chronic infection with a long latency before clinical disease. we followed 214 untreated subjects for 12-42 months to study the natural history of hiv infection: 110 were classified as asymptomatic, 11 as aids-related complex (arc), 15 as aids with kaposi's sarcoma (ks), 31 as aids with opportunistic infections (aids/oi), and 47 were hiv-seronegative controls. the quantitative capacity of serum to complex hiv p24 antigen, termed the p24 bi ... | 1990 | 2111160 |
| kaposi's sarcoma in a human immunodeficiency virus-negative homosexual man. | 1991 | 2056211 | |
| oral kaposi's sarcoma in a woman as a first indication of hiv infection. | although kaposi's sarcoma has been well described in homosexual men at risk for infection with the human immunodeficiency virus, there have been fewer reports of ks in women, and most of these have been in women who became infected with hiv through intravenous drug use. this report describes a woman who had no history of intravenous drug use in whom intraoral ks and hairy leukoplakia were the first indication of her infection with hiv. | 1991 | 2022789 |
| pathogenesis of aids-associated kaposi's sarcoma. | kaposi's sarcoma (ks) is a mesenchymal tumor of unclear etiopathogenesis. the epidemic form of ks occurs in up to 30% of hiv-infected individuals with lesions that have mixed cellularity, spindle cell proliferation, and neoangiogenesis. although not completely defined, the spindle cells, thought to be the tumor cells of ks, are of mesenchymal cell origin, with features resembling endothelial and smooth muscle cells. the establishment of in vitro and in vivo model systems (aids-ks cell culture an ... | 1991 | 2022594 |
| antiretroviral therapy and immunomodulators in patients with aids. | a number of studies have illustrated the effectiveness of hematopoietic growth factors in managing treatment-related cytopenias in patients with human immunodeficiency virus (hiv) infection. one of these factors, granulocyte-macrophage colony-stimulating factor, has been shown to restore absolute neutrophil counts in patients with acquired immunodeficiency syndrome (aids) and kaposi's sarcoma receiving a combination of zidovudine (azt) and interferon alfa. a combination of granulocyte colony-sti ... | 1991 | 2018046 |
| granulocyte-macrophage colony-stimulating factor mitigates the neutropenia of combined interferon alfa and zidovudine treatment of acquired immune deficiency syndrome-associated kaposi's sarcoma. | the combined use of zidovudine (zdv) and interferon (ifn) alfa-2a has been shown to have antiretroviral and antitumor potential benefit in the treatment of acquired immune deficiency syndrome (aids)-associated kaposi's sarcoma (ks). however, the clinical use of this combination is frequently complicated by the overlapping myelotoxicity of these agents. we report here the results of a phase i/ii study in which granulocyte-macrophage colony-stimulating factor (gm-csf) was used for those ks patient ... | 1991 | 2016623 |
| characterization of long-term survivors of acquired immunodeficiency syndrome. the long-term survivor collaborative study group. | of 4,073 reported patients diagnosed with aids from 1978 through 1983, 821 (20%) were not reported to be dead by january 1987. of these apparent long-term survivors, 780 (95%) were reported from 14 states or from local areas where collaborating health departments conducted special follow-up investigations: 119 (15%) were found to be alive, 475 (61%) were dead, and 186 (24%) were lost to follow-up. health departments obtained consent to collect additional clinical and laboratory information on 48 ... | 1991 | 2007973 |
| pancreatic involvement in human immunodeficiency virus infection. | involvement of the pancreas by human immunodeficiency virus (hiv) infection has not been adequately addressed and is the object of this review. i analyzed the english language literature, including single case reports of pancreatic involvement and larger series reporting detailed pathological findings of patients with hiv infection. nonspecific pathological changes in the pancreas are frequently seen at autopsy of hiv-infected patients, but are not more common than in controls. several types of ... | 1991 | 2007747 |
| urological manifestations of hiv-related disease. a case of aids-associated testicular seminoma, kaposi's sarcoma and possible intracranial lymphoma. | a wide variety of pathologies afflicting the genitourinary tract can be displayed by patients infected with the human immunodeficiency virus (hiv), including both infective and neoplastic conditions. treatment can often be offered for such conditions using a combination of therapeutic approaches. these conditions should be looked for specifically in patients with hiv infection as treatment may improve their quality of life. a case is presented of a testicular seminoma (appearing in association w ... | 1991 | 2004234 |
| hypothyroidism due to destruction of the thyroid by kaposi's sarcoma. | a case of hypothyroidism that manifested as depression and deteriorating functional status and that ultimately resulted in the death of a 41-year-old patient with aids is described. postmortem examination revealed destruction of the thyroid gland by kaposi's sarcoma. analysis of stored serum samples revealed that the patient had become profoundly hypothyroid during his terminal illness. practitioners are reminded of the need to exclude metabolic causes when treating encephalopathy in patients in ... | 1991 | 1962092 |
| gastric adenocarcinoma associated with human immunodeficiency virus (hiv) infection. | gastric adenocarcinoma developed in a 33-year-old homosexual man with human immunodeficiency virus (hiv) infection. this type of cancer is very rare in a man of his young age and in the absence of other factors. the tumor was aggressive and led to rapid death. whereas kaposi's sarcoma and lymphomas have been associated with hiv, there are only a few documented cases of adenocarcinoma associated with a suppressed immune system. the association between hiv infection and the virulence of this tumor ... | 1991 | 1938507 |
| human immunodeficiency virus-related lymphoma. prognostic factors predictive of survival. | in an attempt to determine factors predictive of survival in patients seropositive for human immunodeficiency virus (hiv) with acquired immune deficiency syndrome (aids)-related lymphoma, the authors studied 60 such patients, all of whom were treated with curative intent. eleven patients presented with lymphoma primary to the brain (p-cns); the remaining 49 had systemic aids-related lymphoma. patients with p-cns lymphoma had more severe underlying hiv-related disease than did patients with syste ... | 1991 | 1933784 |
| adverse virus-drug interactions. | over the last 3 decades, epidemiologists and clinicians have identified a few clinical entities that appear to result when a viral infection and a chemical exposure overlap and interact. ampicillin rash during infectious mononucleosis, reye's syndrome following salicylate ingestion and certain viral infections, and the association of aids-related kaposi's sarcoma with abuse of nitrite inhalants and infection due to human immunodeficiency virus are examples of such phenomena. preclinical research ... | 1991 | 1925290 |
| experience with rehabilitation in the acquired immunodeficiency syndrome. | patients with the acquired immunodeficiency syndrome (aids) represent a novel referral population for rehabilitation services. limited information about the rehabilitation needs of individuals with human immunodeficiency virus infection is available. we reviewed 51 consecutive patients with aids referred to a rehabilitation consult service. common problems encountered included generalized deconditioning (27%) and neurologic dysfunction (45%). neurologic presentations were diverse and included he ... | 1991 | 1878178 |
| hiv-related malignancies. | since the recognition of kaposi's sarcoma as a manifestation of the acquired immunodeficiency syndrome, subsequent malignancies such as non-hodgkin's b-cell lymphoma and primary central nervous system lymphoma have been found to be associated with individuals infected with the human immunodeficiency virus (hiv). the epidemiology, clinical manifestations, and current concepts of pathogenesis are reviewed in this article. in addition, the relation between hiv and other malignancies, including hodg ... | 1991 | 1873928 |
| kaposi's sarcoma in a child after autologous bone marrow transplantation for non-hodgkin's lymphoma. | a case of kaposi's sarcoma in a child with no serologic evidence of human immunodeficiency virus (hiv) infection is reported. a 7-year-old boy with stage iv non-hodgkin's lymphoma, after conventional chemotherapy, underwent autologous bone marrow transplantation (abmt). five months later he presented with supraclavicular mass and mediastinal enlargement. a bone marrow biopsy showed hypoplasia with no signs of the underlying disease, whereas the excised mass revealed a typical histologic pattern ... | 1991 | 1873788 |
| angiosarcoma arising in kaposi's sarcoma (pleomorphic kaposi's sarcoma) in a patient with human immunodeficiency virus disease. armed forces retroviral research group. | 1991 | 1869659 | |
| [hodgkin's disease, kaposi's sarcoma and infection by the human immunodeficiency virus]. | 1991 | 1790289 | |
| pathogenesis of hiv-related malignancies. | human immunodeficiency virus (hiv)-1 infection is associated with increased frequency of kaposi's sarcoma and high-grade b-cell lymphoma. several other cancers in hiv-1-infected individuals have been reported, although without statistically significant increase in their respective occurrences. although hiv-1 does not infect either kaposi's sarcoma-derived spindle cells or b lymphocytes in vivo, viral proteins in vitro have been shown to be mitogenic to both kaposi's sarcoma-derived spindle cells ... | 1991 | 1751580 |
| technetium-99m-dtpa aerosol and gallium-67 scanning in pulmonary complications of human immunodeficiency virus infection. | we retrospectively compared the results of 67ga chest scans and 99mtc-dtpa aerosol clearance measurements with those of fiberoptic bronchoscopy in 88 patients infected with the human immunodeficiency virus. of 100 investigations, a pulmonary infection was diagnosed in 39, mainly pneumocystis carinii pneumonia and a noninfectious disorder was found in 42, mainly kaposi's sarcoma and lymphocytic alveolitis. gallium scans and dtpa clearance were abnormal respectively in 74% and 92% of infectious co ... | 1992 | 1731002 |
| the interferons. mechanisms of action and clinical applications. | the interferons (ifn) are one of the body's natural defensive responses to such foreign components as microbes, tumors, and antigens. the ifn response begins with the production of the ifn proteins (alpha, beta, and gamma), which then induce the antiviral, antimicrobial, antitumor, and immunomodulatory actions of ifn. recent advances have led to food and drug administration approval of five clinical indications for ifn. interferon alfa is approved for hairy-cell leukemia, condyloma acuminatum, k ... | 1991 | 1715409 |
| predictive value of cd4 lymphocyte numbers for the development of opportunistic infections and malignancies in hiv-infected persons. | infection with the human immunodeficiency virus (hiv) results in progressive depletion of the cd4 subset t-lymphocytes and the development of opportunistic infections and certain malignancies. charts were reviewed for 185 hiv-infected individuals with 265 aids-defining illnesses (adis) who had t-lymphocyte subset analyses performed within 2 months prior to or 1 month following the diagnosis. also included were 22 hiv-infected patients with oral candidiasis and 20 with asymptomatic infection. sig ... | 1991 | 1677419 |
| granulomatous vasculitis occurring after cutaneous herpes zoster despite absence of viral genome. | granuloma annulare, sarcoidal and other granulomatous dermatitides, pseudolymphoma, lymphoplasmacytoid lymphoma, and kaposi's sarcoma have been described as sequelae of herpes zoster. we report a new postzoster reaction, granulomatous vasculitis, that caused flat-topped papules restricted to the affected dermatome. polymerase chain reaction failed to detect varicella-zoster virus in a biopsy specimen. these results suggest that granulomatous vasculitis occurs without persistence of the viral gen ... | 1991 | 1648109 |
| recent development of studies on traditional chinese medicine in prophylaxis and treatment of aids. | who statistics indicated that as of october 1, 1991 there were 418,403 acquired immunodeficiency syndrome (aids) patients in the world, and an estimated 5-10 million persons infected with the human immunodeficiency virus (hiv) were at risk of developing aids. 50% of aids victims have died. it has been reported that after 1 year of clinical use hiv could develop resistance to azt (azidothymidine), the only effective drug used worlwide and recommended for clinical use by the us government. aids ... | 1992 | 1597994 |
| evidence for a sexually transmitted cofactor for aids-related kaposi's sarcoma in a cohort of homosexual men. | we examined factors associated with the subsequent development of aids-related kaposi's sarcoma in a cohort of 353 homosexual men infected with human immunodeficiency virus (hiv). cumulative incidence curves for the development of kaposi's sarcoma and opportunistic infection were stratified over a wide range of variables at enrollment, including those related to demographics, sexual behavior, illicit drug use, and medical history. we found no strong associations between any of these variables an ... | 1992 | 1591318 |
| anorectal lesions in human immunodeficiency virus-infected patients. | in a prospective study, we analysed the anorectal lesions observed in 148 human immunodeficiency virus-infected patients and compared the data with those reported in the literature. the majority of the patients (97.3%) were homosexual or bisexual men. the mean age of the population was 34.2 years. a history of previous sexually transmitted diseases was found in 79.7% of the male patients. the stage of hiv-related disease, according to the centers for disease control classification, could be dete ... | 1992 | 1588221 |
| perineal manifestations of hiv infection. | individuals who are seropositive for the human immunodeficiency virus (hiv) frequently have disorders affecting the anorectum, yet little has been reported on this subject. we reviewed our initial experience with patients with hiv referred to the division of colon and rectal surgery. forty patients (age range, 19-45 years; mean, 32.2 years) were seen between 1985 and 1989. the mean duration of symptoms was six months (range, one week to six years). in 25 patients (63 percent), more than one anor ... | 1992 | 1582350 |
| aspiration cytology of lymphocyte-depleted hodgkin's lymphoma in a man infected with the human immunodeficiency virus. a case report. | we describe the case of a 39-year-old, human immunodeficiency virus (hiv)-positive man who was noted to have a chest wall mass on physical examination. fine needle aspiration of the mass showed atypical spindle cells. excisional biopsy of the mass revealed hodgkin's lymphoma with areas of lymphocyte depletion consisting of a proliferation of myofibroblastic cells. the myofibroblastic, lymphocyte-depleted areas in the hodgkin's lymphoma mass corresponded to the spindle cells seen in the aspirate. ... | 1992 | 1580125 |
| increasing impact of hiv infection on hospitalizations in the united states, 1983-1988. | during 1983-1988, hospitalizations of patients with a diagnosis of human immunodeficiency virus (hiv) infection increased from 1.3 to 33.7 per 100,000 persons. we used the national hospital discharge survey, which is based on a representative sample of discharges from nonfederal short-stay hospitals, to describe illnesses among hospitalized patients with hiv infection. of 222,200 such hospitalizations during 1983-1988, most occurred among persons who were 25-44 years of age (79%), white (66%), a ... | 1992 | 1560347 |
| hepatobiliary scintigraphy in the diagnosis of aids-related sclerosing cholangitis. | twenty human immunodeficiency virus (hiv)-positive patients were studied who presented with right upper quadrant abdominal pain, with or without abnormal biochemical liver function tests, in whom aids-related sclerosing cholangitis (asc) was suspected. the results obtained from hepatobiliary scintigraphy using 99tcm-iodida were compared with data from endoscopic retrograde cholangiopancreatography (ercp), ultrasound and histological data from liver biopsy or post mortem. 99tcm-iodida was abnorma ... | 1992 | 1557214 |
| cluster analysis of the metastatic patterns of human immunodeficiency virus-associated kaposi's sarcoma. | kaposi's sarcoma (ks) is a pleomorphic spindle cell lesion whose incidence has markedly increased among patients infected with the human immunodeficiency virus (hiv), especially among those whose primary risk factor is homo/bisexual transmission. the question as to whether ks is even a true neoplasm still remains largely unsettled due to the body of epidemiologic and histologic evidence suggesting an infectious etiology of the lesion. accordingly, very few studies have been published regarding s ... | 1992 | 1555840 |
| auditory brain stem responses in patients with human immunotropic virus infection of different stages. | thirty patients (26 men, 4 women) with human immunotropic virus infection of different stages were examined. eleven patients had a history of i.v. drug abuse, nine patients had a history of treated lues infection, and one patient suffered from kaposi's sarcoma. at the time of the examination, opportunistic infections or acute encephalitis were not apparent in any patient. all patients underwent otoneurological examinations, including pure-tone audiometry, caloric vestibular testing, and recordin ... | 1992 | 1541374 |
| correlation of oral disease with the walter reed staging scheme for hiv-1-seropositive patients. | this study correlates the prevalent oral disease findings in 390 patients seropositive for human immunodeficiency virus type 1 (hiv-1) with their level of staging (walter reed) and depletion of peripheral helper t lymphocytes (cd4+). chronic lymphadenopathy of the head and neck was a common finding (59.2%) that occurred early in staging progression and did not correlate with depression of helper t-cell levels. of the three prevalent oral disease findings (oral hairy leukoplakia (ohl), candidiasi ... | 1992 | 1532056 |
| pulmonary function in human immunodeficiency virus infection. a prospective 18-month study of serial lung function in 474 patients. | to investigate the development of a reduced dlco in patients with hiv-related disease, we studied 474 hiv-seropositive patients and performed serial lung function measurements over 18 months. the mean values of dlco at presentation were lower in patients with more advanced hiv disease compared with asymptomatic hiv-seropositive patients (dlco 88% of predicted). when compared with the dlco in asymptomatic hiv-seropositive patients, the dlco had reduced values in patients with persistent generaliz ... | 1992 | 1519857 |
| [bacteremia caused by non-typhoid salmonellas during an infection by the human immunodeficiency virus (hiv) in the african adult]. | infection caused by non-typhous salmonellae during the course of hiv infection is known since 1983. the authors report on 103 bacteremiae of this type found in one year. diagnosis has been based on hemocultures. 86 patients out of 103 were hiv+. all of them were febrile. 67 suffered from digestive disorders, 33 with diarrhoea. splenomegalia was noted in 16 cases and consciousness troubles in 13 cases. at the admission, 8 complications were observed. other infections were associated in 86 cases p ... | 1992 | 1494316 |
| aids acquired by drug consumption and other noncontagious risk factors. | the hypothesis that human immunodeficiency virus (hiv) is a new, sexually transmitted virus that causes aids has been entirely unproductive in terms of public health benefits. moreover, it fails to predict the epidemiology of aids, the annual aids risk and the very heterogeneous aids diseases of infected persons. the correct hypothesis must explain why: (1) aids includes 25 previously known diseases and two clinically and epidemiologically very different epidemics, one in america and europe, the ... | 1992 | 1492119 |
| human immunodeficiency virus as a risk factor in miscellaneous cancers. | the association of malignancies, such as non-hodgkin's lymphoma and kaposi's sarcoma, with human immunodeficiency virus infection has been recognized since the beginning of the epidemic. however, an increasing number of tumors not diagnostic of acquired immunodeficiency syndrome has been described in this setting. taking into consideration that survival of patients with human immunodeficiency virus infection is increasing because of improvement of supportive care and better control of human immu ... | 1992 | 1457506 |
| clinical aspects of kaposi's sarcoma. | kaposi's sarcoma is the most common tumor found in patients with the acquired immunodeficiency syndrome. this opportunistic neoplasm has characteristics of a sexually transmitted disease. growth factors, cytokines, immune suppression, and interaction with infectious organisms all appear to play a role in the pathogenesis of this enigmatic disorder. the manifestations of kaposi's sarcoma are protean, and lesions may appear at any time in the course of human immunodeficiency virus disease, remain ... | 1992 | 1457502 |
| hiv disease and aids in women: current knowledge and a research agenda. | the study of the clinical manifestations, progression, and outcome of human immunodeficiency virus (hiv) infection in women has begun in earnest. aids-defining diseases that are more common in women than in men include wasting syndrome, esophageal candidiasis, and herpes simplex virus disease, whereas kaposi's sarcoma is rare. non-aids-defining gynecological conditions such as vaginal candida infections and cervical pathology are prevalent among women at all stages of hiv infection. associations ... | 1992 | 1453325 |
| recognizing the oral manifestations of aids. | the first sign of hiv infection may be an unusual or rapidly progressive condition of the oral cavity, including malignancies such as kaposi's sarcoma. early diagnosis of these oral conditions can lead to early diagnosis of hiv infection and subsequent treatment with antiretroviral agents that may improve the prognosis. this illustrated review outlines the presenting signs and symptoms of the most common oral manifestations of the aids virus, including hairy leukoplakia, candidiasis, kaposi's sa ... | 1992 | 1449978 |
| effects of cytokines from activated immune cells on vascular cell growth and hiv-1 gene expression. implications for aids-kaposi's sarcoma pathogenesis. | kaposi's sarcoma (ks) arises more frequently in homosexual and bisexual men than in other groups of hiv-1 infected individuals. clinico-epidemiologic data indicate that homosexuals often are infected with multiple microbial agents and/or subjected to other antigenic stimuli, preceding or accompanying hiv-1 infection. signs of immune activation, in fact, frequently have been detected in these individuals, and the onset of ks can precede any sign of immunodeficiency. these data have suggested that ... | 1992 | 1431144 |
| immunologic markers of progression to acquired immunodeficiency syndrome are time-dependent and illness-specific. | since prevalent cohorts may be biased by the duration of human immunodeficiency virus (hiv) infection (onset bias), it is useful to assess the potential predictive value of markers in incident cohorts of hiv-positive subjects for whom the date of seroconversion is known or can reliably be estimated. of 131 homosexual men with hiv-1 seroconversion from new york city and washington, dc, who were evaluated annually beginning in 1982, 60 developed acquired immunodeficiency syndrome (aids) by the end ... | 1992 | 1384311 |
| inhibition of development of kaposi's sarcoma-related lesions by a bacterial cell wall complex. | in vitro and in vivo model systems for the study of human immunodeficiency virus (hiv)-associated kaposi's sarcoma (ks) were used to evaluate compounds for their potential as therapeutic agents. a sulfated polysaccharide-peptidoglycan compound (sp-pg) produced by bacteria controlled the in vitro growth of acquired immunodeficiency syndrome (aids)-associated, ks-derived spindle-shaped cells (aids-ks cells) at noncytotoxic concentrations. angiogenesis induced by aids-ks cells in the chicken chorio ... | 1992 | 1371891 |
| oral signs and symptoms in 160 greek hiv-infected patients. | one hundred and sixty hiv-infected greek patients were prospectively examined and the oral signs and symptoms were recorded. at the time of oral examination, 76 patients were asymptomatic seropositive, 47 were in arc stage and 37 had aids. one or more oral findings were recorded in 90.6% of the patients while a total of 33 different lesions were observed. the more common oral lesions (highly suspicious) were candidiasis (61%), hairy leukoplakia (24%), periodontitis (19%), necrotizing gingivitis ... | 1992 | 1316436 |
| partial characterization of a herpes-type virus (k9v) derived from kaposi's sarcoma. | a herpes-type virus that was originally isolated from a cell culture (designated k9v) derived from a tumor biopsy specimen from a patient with kaposi's sarcoma was partially characterized. the host range of k9v, as determined by the induction of virus-specific cytopathology, synthesis of antigens, and plaque formation, was limited to human cells and particularly to fibroblasts. immunofluorescence and complement fixation assays confirmed the specificity of the presence of cytomegalovirus (cmv)-ty ... | 1977 | 195073 |
| de novo kaposi's sarcoma in renal transplantation. case report and brief review. | this report describes a de novo development of kaposi's sarcoma in a puerto-rician man 9 months after a cadaveric renal transplant. progression of the disease was observed despite local irradiation, while the patient remained immunosuppressed with prednisone and azathioprine. this was accompanied by depressed immunologic tests. discontinuation of azathioprine and addition of chemotherapy (bleomycin and vincristine), while continuing prednisone to maintain functional survival of renal allograft, ... | 1976 | 59624 |