Publications

the cpg dinucleotide and human genetic disease.	reports of single base-pair mutations within gene coding regions causing human genetic disease were collated. thirty-five per cent of mutations were found to have occurred within cpg dinucleotides. over 90% of these mutations were c----t or g----a transitions, which thus occur within coding regions at a frequency 42-fold higher than that predicted from random mutations. these findings are consistent with methylation-induced deamination of 5-methyl cytosine and suggest that methylation of dna wit ...	1988	3338800
iron metabolism in the erythrophagocytosing kupffer cell.	like the peritoneal macrophage, the isolated kupffer cell is capable of processing and releasing iron acquired by phagocytosis of immunosensitized homologous red blood cells. when erythrophagocytosis is restrained to levels which do not affect cell viability, or less than 1.5 red cells/macrophage (phagocytic index of 150%), over 40% of iron acquired from red cells is released within 24 hr. more active erythrophagocytosis results in greater release of iron but progressive deterioration in cell vi ...	1988	3338718
open-ended vasectomy.		2012	3338595
treatment of massive acute pulmonary embolism. the use of low doses of intrapulmonary arterial streptokinase combined with full doses of systemic heparin.	the efficacy of low-dose, locally administered streptokinase (sk) combined with full therapeutic systemic doses of heparin was investigated. seven patients with angiographically proven massive acute pulmonary embolism were treated. streptokinase, 10,000-20,000 units/hour, was administered directly into the left or right pulmonary artery for 9 to 24 hours. heparin was administered concurrently. the number of unperfused segments of the infused lung shown on the lung scan decreased from 5 +/- 2 to ...	2012	3338289
[protective effect of lithium oxybutyrate on the ischemic myocardium].	in the experiments on different animal species (mice, cats, dogs) lithium hydroxybutyrate has been shown to have antihypoxic and anti-ischemic effects. lithium hydroxybutyrate improved the functional state of the ischemic myocardium, stimulated the accumulation of macroergic phosphates (atp) in the heart, protected the ischemic myocardium and delayed the progression of the reversible ischemic damage into the irreversible one. the improvement of the collateral coronary circulation plays an import ...	1988	3337880
taking a baby.		2012	3337152
osteosclerotic metastases with severe hypocalcemia, parathyroid hormone resistance, anemia, and cardiac failure.		2012	3337123
effects of cyclosporin a and predegeneration on survival and regeneration of peripheral nerve allografts in rabbits.	axonal regeneration across 64 median nerve grafts in 34 rabbits was studied histologically to determine the optimal conditions for nerve allografting. axonal regeneration across allografts in cyclosporin a-treated animals was satisfactory, but it occurred more slowly and with more inflammation and fibrosis than in autografts. without immunosuppression, fresh allografts were rejected. however, in immunocompetent hosts, allografts rendered less immunogenic by predegeneration were not rejected, and ...	1988	3336858
the efficacy of oral zinc therapy as an alternative to penicillamine for wilson's disease.		2000	3336426
five-year immunologic memory in swedish volunteers after oral cholera vaccination.		1988	3335813
studies on compound i formation of the lignin peroxidase from phanerochaete chrysosporium.	ligninase, isolated from the wood-destroying fungus phanerochaete chrysosporium, catalyzes the oxidation of lignin and lignin-related compounds. ligninase reacts with h2o2 to form the classical peroxidase intermediates compounds i and ii. we have determined the activation energy of ligninase compound i formation to be 5.9 kcal/mol. the effect of ph and ionic strength on the rate of ligninase compound i formation was studied. in contrast to all other peroxidases, no ph effect was observed. this i ...	1988	3335539
the role of computed tomography in the evaluation of post-mastectomy locally recurrent breast cancer.	the rate of post mastectomy local-regional recurrence of breast cancer has remained in the range of 10-30% for decades. the traditional treatment, external beam radiation therapy, is successful in eradicating local disease in most cases, but re-recurrences are seen in about 50% of patients. since 1982, 33 patients with such recurrences have undergone evaluation with computed tomography (ct) at our institution as part of their diagnostic work-up. in 22/33 (67%), ct revealed unsuspected disease, a ...	2011	3335463
volunteer studies of deletion mutants of vibrio cholerae o1 prepared by recombinant techniques.	vibrio cholerae o1 a-b- vaccine strain jbk 70 and a-b+ cvd 101 prepared by recombinant dna techniques from pathogenic ei tor inaba n16961 and classical ogawa 395, respectively, were fed to 38 volunteers in single doses of 10(4) to 10(10). although severe diarrhea did not occur in any vaccine, more than one-half developed mild diarrhea. these attenuated strains colonized well and elicited prominent vibriocidal and antitoxic (cvd 101) antibody responses. recipients of a single dose of jbk 70 were ...	1988	3335402
megakaryocytes increase in size within ploidy groups in response to the stimulus of thrombocytopenia.	experiments were done to determine if sizes of megakaryocytes within a defined maturation stage were strictly determined by amount of nuclear dna. normal mice, mice recovering from an acute episode of thrombocytopenia induced by a single injection of heterologous antiplatelet serum (aps), and mice with sustained thrombocytopenia from daily injections of aps were examined. areas of mature megakaryocytes were measured in bone marrow smears stained with polychromatic stains. the nuclear dna content ...	2006	3335233
biochemical analysis of decreased ornithine transport activity in the liver mitochondria from patients with hyperornithinemia, hyperammonemia and homocitrullinuria.	hyperornithinemia, hyperammonemia and homocitrullinuria (hhh disorder) is an inherited metabolic disorder which shows peculiar amino acid changes in the serum and urine. the primary defect is considered to be the transport of ornithine across the mitochondrial membrane, but there is no direct evidence for this so far. we have analyzed ornithine transport activities in the liver mitochondria from three patients with hhh disorder. in coupled liver mitochondria we demonstrated low activities of cit ...	2012	3334877
effects of levamisole on experimental infections by plasmodium berghei in mice.		1987	3333878
effects of levamisole on experimental infections by plasmodium berghei in mice.		1987	3333878
t cell factors involved in the isotype-specific regulation of the ige antibody response.		1987	3333779
ultrasonography in ocular trauma.		2011	3333767
herpes gestationis.		2012	3333477
myocardial lymphocytes. fact, fancy, or myocarditis?	the diagnosis of active lymphocytic myocarditis by the use of the endomyocardial bioptome is at present a hotly debated topic. however, the question of whether lymphocytes reside in the myocardium of individuals without systemic or cardiac disease has rarely been addressed, but is obviously of critical importance in helping to resolve this issue. therefore, we examined endomyocardial biopsies obtained from 86 young heart disease-free cardiac transplant donors at the time of transplantation. foci ...	2012	3331950
imipenem/cilastatin for pediatric infections in hospitalized patients.	one hundred and four children who were hospitalized for documented or suspected non-cns bacterial infections (56 males/48 females, 22 days to 15 years old) were treated with intravenous imipenem/cilastatin for 9.4 days (range 3 to 28 days). children up to three years of age received 100 mg/kg/day and older children 60 mg/kg/day, administered in four divided doses. bacterial pathogens were isolated before therapy in 85%. diagnoses in the 74 evaluable patients included bronchopneumonia with or wit ...	1987	3331043
early discharge with domiciliary visits and hospital care: parents' experiences of two modes of post-partum care.		2002	3331035
[injection technology for slides of cobalt-based alloys. experimental principles and technical procedures].		2012	3330819
[trial use of embryonal and early-fetal thymus extracts in the treatment of non-healing skin defects. ii. crural ulcers in humans].		1987	3329747
the hemolytic activity of some strains belonging to genus vibrio.		1987	3329505
child abuse: detecting and reporting.		2011	3329222
evaluation of tenoxicam in rheumatology--clinical trial results in argentina and brazil.	the therapeutic activity of tenoxicam, a thienothiazine derivative with analgesic and anti-inflammatory properties, has been studied by 15 investigators in argentina and brazil. twenty-nine clinical trials were performed in a total of 747 patients suffering from rheumatoid arthritis (270), cox- and gonarthrosis (190), extra-articular inflammation (250) and acute gout (37). out of the patients studied, 507 received tenoxicam and 240 were given comparative preparations. in 76% of the patients 20 m ...	2011	3329108
evaluation of tenoxicam in rheumatology--clinical trial results in argentina and brazil.	the therapeutic activity of tenoxicam, a thienothiazine derivative with analgesic and anti-inflammatory properties, has been studied by 15 investigators in argentina and brazil. twenty-nine clinical trials were performed in a total of 747 patients suffering from rheumatoid arthritis (270), cox- and gonarthrosis (190), extra-articular inflammation (250) and acute gout (37). out of the patients studied, 507 received tenoxicam and 240 were given comparative preparations. in 76% of the patients 20 m ...	2011	3329108
effects of t-2 toxin on induction of petite mutants and mitochondrial function in saccharomyces cerevisiae.	the influence of the trichothecene mycotoxin t-2 on the mitochondria of saccharomyces cerevisiae was studied. t-2 is a cytotoxic molecule inhibiting growth and macromolecular synthesis in s. cerevisiae. at low concentrations, t-2 toxin arrested yeast growth on glycerol medium and at higher concentrations, it arrested growth on glucose medium. the toxin was not capable itself of inducing petite mutations. its inhibitory effect on the growth of petite strains, of both chromosomally isogenic and no ...	1986	3329043
pain suppression after pulpectomy with preoperative flurbiprofen.		1995	3327906
liver membrane antibodies in chronic delta hepatitis.	the correlation between the presence of liver membrane antibodies (lma) and delta superinfection in chronic hepatitis b was studied in 136 chronic hepatitis patients, 20 hepatitis b surface antigen asymptomatic carriers and 50 healthy controls, by testing for the presence of lma, hepatitis b virus markers and anti-delta (anti-hd). neither anti-hd nor lma were detected in controls or in asymptomatic carriers. lma positivity was statistically higher (p less than 0.001) in anti-hd-positive patients ...	1987	3327717
[isolated azygos continuation of the inferior vena cava. (absence of the retrohepatic segment of the inferior vena cava)].	the isolated azygos continuation of the inferior vena cave is a very rare variation of this organ. it is accompanied by the absence of the retrohepatic segment of the vena cava with two new observations, the literature is revised and the origin discussed.	2008	3327548
indirect immunofluorescence application in the epidemiological study of hepatitis a.	we used iif test for seroepidemiological study on 531 sera divided in age-groups obtained from apparently healthy subjects of rome. our results confirm the endemicity of hav (hepatitis a virus) infection in rome with a prevalence of more than 50%. the application of the anti-hav iif (indirect immunofluorescence) test to a large number of sera demonstrated its usefulness as a quantitative and qualitative test in the epidemiological field.	1987	3327512
[the effect of inhibitor of angiotensin-converting enzyme on uric acid metabolism].		2012	3326955
ascending urinary tract infections in rats induced by staphylococcus saprophyticus and proteus mirabilis.	ascending pyelonephritis was induced by staphylococcus saprophyticus and proteus mirabilis both by inoculating the organisms separately and in combination into rat bladders. bacterial cultures of tissue homogenates showed that pyelonephritis by both bacteria occurred significantly more often in rats where the two organisms were instilled concomitantly, suggesting a synergistic virulence between the two species. the antibody response to the different organisms was the same either the bacteria wer ...	1987	3326399
ascending urinary tract infections in rats induced by staphylococcus saprophyticus and proteus mirabilis.	ascending pyelonephritis was induced by staphylococcus saprophyticus and proteus mirabilis both by inoculating the organisms separately and in combination into rat bladders. bacterial cultures of tissue homogenates showed that pyelonephritis by both bacteria occurred significantly more often in rats where the two organisms were instilled concomitantly, suggesting a synergistic virulence between the two species. the antibody response to the different organisms was the same either the bacteria wer ...	1987	3326399
ribonucleotide reductase inhibitors as anticancer and antiviral agents.		2012	3326028
obsessive compulsive disorder in children.		2012	3326008
a new keratinolytic proteinase from clinical isolates of trichophyton mentagrophytes.		1987	3325542
the inflammatory theory of asthma.	in summary, these observations suggest a model for asthma which is summarized in table iii. initially, mast cells and possibly other bronchial cells, e.g., alveolar macrophages, are activated either in an ige-dependent or, in intrinsic asthma, in an ige-independent fashion. these cells release two sets of mediators which may be either preformed or newly synthesized. one set of mediators is responsible for the immediate bronchospastic response. this bronchospasm is transient, readily reversible, ...	2012	3325413
ear trauma.	ear trauma, a common problem in emergency medicine is discussed in this review. although injuries of the ear are not life threatening, they may account for significant morbidity. patients may experience severe pain, hearing loss, tinnitus, or vertigo. poor healing of injuries to the external ear may result in a cosmetic deformity as well. ear trauma may occur secondary to a number of mechanisms, including loud noises, penetrating or blunt trauma, blast injury, chemical exposure, and thermal inju ...	2012	3325273
[molecular-genetic aspects of drug therapy of malignant tumors].	state and prospects of the drug cancer therapy are examined in the light of achievements of modern molecular oncology. special attention is paid to the molecular genetic analysis of the appearance of individual and multiple cellular drug resistance in connection with amplification of definite genes as well as oncogenes. the idea about the possible role of oncogene activation as a universal cell reaction in response to an injury of environmental factors is advanced. it concerns both oncogenesis a ...	2012	3325267
a study of beta-cell function after glucagon stimulation in thalassaemia major treated by high transfusion programme.	an increased incidence of diabetes mellitus and glucose intolerance has been reported in thalassaemia major treated with a high transfusion programme (htp). to investigate beta-cell function, serum immunoreactive insulin (iri), c-peptide (cp) and glucose were measured fasting and at 3, 6 and 10 min after i.v. administration of 1 mg glucagon in 20 thalassaemia patients treated by many transfusions and in nine healthy control subjects. fasting c-peptide concentrations (mean +/- sem) were higher in ...	2012	3325197
enumeration of vibrio cholerae o1 in bangladesh waters by fluorescent-antibody direct viable count.	a field trial to enumerate vibrio cholerae o1 in aquatic environments in bangladesh was conducted, comparing fluorescent-antibody direct viable count with culture detection by the most-probable-number index. specificity of a monoclonal antibody prepared against the o1 antigen was assessed and incorporated into the fluorescence staining method. all pond and water samples yielded higher counts of viable v. cholerae o1 by fluorescent-antibody direct viable count than by the most-probable-number ind ...	1987	3324967
physiological role of growth hormone in adult life.	some historical background on the physiological effects of pituitary gland extract and later of purified hgh in experimental animals is given, and the regulatory role of hgh in the human adult is reviewed. the effects of hgh on carbohydrate, protein and lipid metabolism are complex and closely linked to the action of other hormones, particularly insulin.	1987	3324637
motor function of the ileal j pouch and its relation to clinical outcome after ileal pouch-anal anastomosis.		2012	3324500
determinisms of odontogenesis.		2012	3324212
[spasmophilia: a new interpretation of psychogenic reactions in dental studies?].		2012	3323870
sterol and phospholipid acyl chain alterations in saccharomyces cerevisiae secretion mutants as a function of temperature stress.	analyses of free sterol, steryl ester and fatty acid components from yeast secretion mutants indicated that free and esterified sterol remained relatively constant over a growth range of 24 c to 34 c. the saturated fatty acid components (16:0 and 18:0) increased while the unsaturated fatty acids (16:1 and 18:1) decreased as the growth temperature increased. in secretory mutants, fatty acid composition changes are more pronounced than in the wild-type strain. a shift toward increased saturated an ...	1987	3323755
sterol and phospholipid acyl chain alterations in saccharomyces cerevisiae secretion mutants as a function of temperature stress.	analyses of free sterol, steryl ester and fatty acid components from yeast secretion mutants indicated that free and esterified sterol remained relatively constant over a growth range of 24 c to 34 c. the saturated fatty acid components (16:0 and 18:0) increased while the unsaturated fatty acids (16:1 and 18:1) decreased as the growth temperature increased. in secretory mutants, fatty acid composition changes are more pronounced than in the wild-type strain. a shift toward increased saturated an ...	1987	3323755
antidesmosomal monoclonal antibody in the diagnosis of intracranial tumours.	immunocytochemistry has been applied extensively to the diagnosis of intracranial tumours, but meningiomas still present a diagnostic problem. however, desmosomes have been shown by electron microscopy to be present in meningiomas, and this distinguishes them from gliomas. this paper describes a new monoclonal antibody, 11-5f, against desmosomal proteins 1 and 2 (desmoplakins) and assesses its usefulness in the diagnosis of meningiomas and other intracranial tumours. a total of 74 surgically rem ...	2012	3323433
long-term in vitro cultivation of plasmodium berghei.		1987	3323090
mode of action of nitro-heterocyclic compounds on escherichia coli.	the inhibitory and bactericidal activities of several different nitro-heterocyclic compounds, such as nitrofuran, nitronaphthofuran, nitrobenzofuran, nitroimidazole and nitrothiazole, were assessed in vitro. all these substances except nitroimidazole were active against escherichia coli, though to different degrees. under anaerobic test conditions the antibacterial activity increased slightly. nitroreductase-deficient mutants, however, were highly resistant to all nitro-compounds, indicating tha ...	1987	3322751
the effect of captopril on cutaneous blood flow in patients with primary raynaud's phenomenon.	fifteen patients with primary raynaud's phenomenon received captopril 25 mg or placebo, three times daily for 6 weeks, in a randomized double-blind cross-over study. compared with placebo, captopril produced a significant improvement in cutaneous blood flow but did not alter the frequency or severity of attacks of raynaud's phenomenon.	2008	3322358
a tribute to marion i. barnhart.		2012	3322128
[a case of retroperitoneal liposarcoma].	a case of retroperitoneal liposarcoma is reported. a 42-year-old woman was admitted to our hospital with the complaint of a palpable mass in her left abdomen. intravenous pyelography, barium enema and an ultrasonogram revealed a huge left abdominal tumor. at operation, a huge yellow-brownish tumor found in the retroperitoneal space, was completely removed. the tumor was 32 x 24 x 12 cm and weighed 4,075 g. histologically, it was a myxoid liposarcoma. three courses of adjuvant chemotherapy (cis-p ...	2010	3321958
[review and updating of the diagnostic sensibility of the dexamethasone suppression test and urinary determination of phenylethylamine and 3-methoxy-4-hydroxyphenylethylglycol in the diagnosis of endogenous depression].	60 endogenous depressive patients (dsm iii: 296.2x, 3x, 296.5x) were studied according to the following diagnostic techniques: dst (carroll's standardization), phenyl-ethyl-amine (pea) urinary quantification (spatz's technique) and 3-methoxy-4-hydroxyphenylethyl glycol (mhpg) urinary quantification (bigelow's technique). seven groups were thus obtained according to their being positive in, at least, one of those determinations. the above mentioned techniques allow the finest of discriminations s ...	2010	3321917
evidence that dna involved in the expression of nodulation (nod) genes in rhizobium binds to the product of the regulatory gene nodd.	in rhizobium leguminosarum biovar viciae, the regulatory nodulation nodd gene has at least two functions. it constitutively represses its own transcription and in the presence of inducer flavonoid molecules, it activates the expression of two other nod gene transcriptional units, nodabcij and nodfe. upstream of noda and nodf is a conserved sequence, the nod box, which has been implicated in nodd-mediated transcriptional activation of these genes. dna fragments spanning the nod boxes that precede ...	1987	3320955
[new applications of cytogenetics in the diagnosis of congenital defects].		2012	3320906
self-learning for a bayesian knowledge base: how long does it take for the machine to educate itself?		2012	3320685
the role of extracellular proteases in cell proliferation and differentiation.	proteases have been shown to be capable of inducing two of the most fundamental biologic processes: mitogenesis and cellular differentiation. their proteolytic activity has been the most widely studied enzymatic activity implicated in inducing these processes. protease induction of mitogenesis is a major system for studying the control of this process and studies of possible transmembrane signals have been initiated. proteases have only recently begun to be used as tools for probing the inductio ...	2012	3320517
[bladder catheter--pro and con].		2005	3320511
[ultrasonic study of the liver in the diagnosis of lung cancer metastases].		2005	3320479
[intracellular mechanisms of cholestasis].		2005	3320466
[analysis of hepatofugal flow in portal venous system using ultrasonic doppler duplex system].		2004	3320415
[localization of structural genes of vibrio cholerae cholerae toxin using the recombinant plasmid rp4omega elt].	the recombinant plasmid rp4 omega elt carrying escherichia coli heat-labile enterotoxin elt genes with 70-80% homology with genes vct of vibrio cholerae has been constructed. we used this plasmid to determine localization of the cholerae toxin genes vct on the map of vibrio cholerae cholerae. two types of the donors were revealed in matings of 10 strains of v. cholerae cholerae 569b/rp4 omega elt with the polyauxotrophic recipients rv31 and rv175: some strains had enhanced frequency of mobilizat ...	1987	3319775
recombinant dna technology in the study of autoimmune thyroid disease.	molecular biology techniques are now beginning to be applied to the study of autoimmune thyroid disease. this review provides a background to the molecular biology techniques used, summarizes the limited data presently available in the area of autoimmune thyroid disease, and describes the potential future application of these techniques for further understanding of autoimmune thyroid disease.	2012	3319592
formamidopyrimidine-dna glycosylase of escherichia coli: cloning and sequencing of the fpg structural gene and overproduction of the protein.	an escherichia coli genomic library composed of large dna fragments (10-15 kb) was constructed using the plasmid pbr322 as vector. from it 700 clones were individually screened for increased excision of the ring-opened form of n7-methylguanine (2-6-diamino-4-hydroxy-5n-methyl-formamidopyrimidine) or fapy. one clone overproduced the fapy-dna glycosylase activity by a factor of 10-fold as compared with the wild-type strain. the fapy-dna glycosylase overproducer character was associated with a 15-k ...	1987	3319582
[malignant tumors of the breast: instrumental diagnosis].	nowadays mammary cancer is still the principal cause of neoplastic deaths of females. early diagnosis, through the complementary use of the various diagnostic techniques, is fundamental to improve the prognosis.	2012	3319240
improved immunohistochemical staining of angiotensin ii in rat brain using affinity purified antibodies.	recent immunohistochemical studies that have sought to detect angiotensin ii/iii (aii/aiii) immunoreactive material in the brain have been forced to rely on a small number of antisera because most aii/aiii antibodies have unexplainably proved unsuitable for immunohistochemistry. although extremely useful tools, these antisera have suffered from high background staining. the purpose of this study was to re-examine and characterize the staining using the most popular aii/aiii antiserum (denise) be ...	1987	3319044
localization and retention of mycobacterial antigen in lymph nodes of leprosy patients.	although leprosy, a chronic disease caused by m. leprae, primarily affects skin and peripheral nerves, pathological changes and granulomas have been observed in lymph nodes which are: (a) present in tuberculoid lymph nodes in the absence of acid-fact bacilli and (b) persistent in lepromatous patients even after prolonged treatment. we detected substantial amounts of mycobacterial antigen in 16 leprous lymph nodes using anti-bcg by the peroxidase anti-peroxidase method. the load and distribution ...	1987	3318906
localization and retention of mycobacterial antigen in lymph nodes of leprosy patients.	although leprosy, a chronic disease caused by m. leprae, primarily affects skin and peripheral nerves, pathological changes and granulomas have been observed in lymph nodes which are: (a) present in tuberculoid lymph nodes in the absence of acid-fact bacilli and (b) persistent in lepromatous patients even after prolonged treatment. we detected substantial amounts of mycobacterial antigen in 16 leprous lymph nodes using anti-bcg by the peroxidase anti-peroxidase method. the load and distribution ...	1987	3318906
effect of gdp on the interactions between chloroplast ef-ts and chloroplast and e. coli ef-tu.	the effects of varying concentrations of gdp on the stability of homologous and heterologous ef-tu:ef-ts complexes formed with the elongation factors from the chloroplast of euglena gracilis and from e. coli have been investigated. the complexes formed with chloroplast ef-ts were significantly more stable to gdp-induced dissociation than those formed with e. coli ef-ts. the complex between chloroplast ef-tu and chloroplast ef-ts required nearly 1,000-fold higher concentrations of gdp for dissoci ...	1987	3318834
dynamic instability of microtubules.		2012	3318820
omental pedicle graft in the management of infected ascending aortic prostheses.	two patients had mediastinal infections with chronic draining sinus tracts that involved a vascular prosthesis in the ascending aorta. in 1 patient, a false mycotic aneurysm developed and in the other, a beginning rupture of the proximal suture line. in both patients, the infection was cured by replacing the infected aortic prosthesis combined with wrapping the new prosthesis with a pedicled omental graft. an omental graft was used to protect the vascular prosthesis and minimize the risk of recu ...	1987	3318738
the effects of cholesterol depletion on cellular morphology.	cells of the u937 cell line were grown in delipidated calf serum for 24 and 48 hr. these cells are known cholesterol auxotrophs. when grown for 48 hr without an exogenous source of cholesterol, these cells are known to become depleted of their intracellular cholesterol stores by greater than 95%. the result is an aggregation of the cells upon mild agitation of the culture. examination of the cell aggregate from these cultures revealed cells in various stages of altered morphology. there was a lo ...	2012	3318556
[medico-genetic studies of human provisional organs].		1987	3318529
tendon gliding exercises.	an exercise program for tendon gliding is introduced for use in hand treatment and rehabilitation. the program incorporates thumb range of motion and three basic fist positions: book, fist, and straight fist. the anatomic and experimental basis of this program is discussed. the exercises allow the flexor tendons to glide to their maximum potential and can greatly facilitate therapeutic activities when incorporated in a comprehensive program of occupational and hand therapy.	2012	3318478
pyogenic granuloma on a dermis fat graft in acquired anophthalmic orbits.	we treated exposure of the orbital implant with a dermis fat graft in two patients with an acquired anophthalmic orbit. during the first six postoperative months, a large polypoid tumor of the conjunctiva developed over the grafted tissue in each patient. histologic examination of both lesions disclosed a pyogenic granuloma.	2012	3318476
extracellular matrix of the human lamina cribrosa.	we used immunoperoxidase staining and double immunofluorescent staining to demonstrate the macromolecular components of the extracellular matrix of the lamina cribrosa from young human donors. the cribriform plates were made up of a core of elastin fibers with a sparse, patchy distribution of collagen type iii. the plates were coated with collagen type iv and laminin; these basement membrane components were presumably made by the astrocytes that were distributed on the surfaces of the plates. th ...	1987	3318474
conjoined twins in triplet pregnancy.		2012	3318473
nabumetone in the treatment of active adult rheumatoid arthritis.	one hundred patients were entered in a six-month, double-blind comparison of 1,000 mg nabumetone once daily and 250 mg naproxen twice daily. forty-two patients in each arm of the study were evaluable for efficacy; all were evaluable for safety. there was a low incidence of adverse experiences during this study, with no patients withdrawing from the study because of side effects from either drug. efficacy was equal, with both compounds sharing the same degree and rate of improvement. all of the p ...	2012	3318429
the child with febrile seizures.	febrile seizures are common in children. they are associated with disease outside of the central nervous system and are usually generalized, brief and self-limited. history and physical examination are usually sufficient to rule out central nervous system disease, and an extensive laboratory work-up is seldom indicated. prophylaxis with antiseizure medications is only indicated in certain circumstances. the major risk in one febrile seizure is the increased likelihood of another.	2012	3318356
[familial pheochromocytoma in a daughter (extra-adrenal) and her mother].	the nineteenth kindred of familial pheochromocytoma in japan is reported. a 13-year-old girl had an extra-adrenal pheochromocytoma and her 40-year-old mother had a right adrenal pheochromocytoma. this is the first case of an extra-adrenal pheochromocytoma in familial pheochromocytoma. a statistical analysis was performed on the 46 cases in 19 kindreds reported so far in japan.	2012	3318335
[treatment with intravesical chemotherapy of deep bladder tumors responding to radiotherapy, decreasing their staging].		2012	3318280
abo blood groups and escherichia coli sepsis.		1987	3318030
tissue culture of human fetal pancreas. effects of human serum on development and endocrine function of isletlike cell clusters.	the human fetal pancreas represents a source of insulin-producing beta-cells with a potential for transplantation to diabetic patients. it has previously been shown that such cells can be viably maintained in tissue culture media containing fetal calf serum (fcs) and that these explants continue to synthesize and release insulin. in this study the effects of human serum (hs) on the growth and function of human fetal pancreatic explants have been compared with those of fcs. for this purpose, panc ...	1987	3315788
aids in denmark 1980-1984. immunological, epidemiological and clinical studies among patients and high risk groups.		2012	3315472
measurement of regional myocardial perfusion and mass by subselective hydrogen infusion and washout techniques: a validation study.	a technique was developed for measuring regional myocardial perfusion by intracoronary infusions of hydrogen (h2)-saturated saline. h2 concentration was detected during washout in the pulmonary artery by means of the voltage response of a platinum-tipped electrode. regional myocardial perfusion was calculated from the h2 exponential desaturation curve according to the kety-schmidt principle. in 16 anesthetized open-chest dogs, validation of this technique was performed at baseline, reduced (sten ...	1987	3315296
measurement of regional myocardial perfusion and mass by subselective hydrogen infusion and washout techniques: a validation study.	a technique was developed for measuring regional myocardial perfusion by intracoronary infusions of hydrogen (h2)-saturated saline. h2 concentration was detected during washout in the pulmonary artery by means of the voltage response of a platinum-tipped electrode. regional myocardial perfusion was calculated from the h2 exponential desaturation curve according to the kety-schmidt principle. in 16 anesthetized open-chest dogs, validation of this technique was performed at baseline, reduced (sten ...	1987	3315296
hepatic glycogen storage disease.	the management of patients with glycogen storage disease is based on an understanding of the biochemistry. the outlook for many patients has improved so that they can now grow up normally.	2012	3315070
evaluation of a program to teach health professionals to search medline.	this study analyzes the search behavior of end users who had taken a class in searching medline on the national library of medicine's medlars system. of the class alumni, 58% obtained passwords. most of these were still conducting their own searches twelve to eighteen months later. telephone interviews and search observations indicated that these end users were satisfied with their results and felt they had mastered the basic mechanics of searching. however, appropriate use of explodes and subhe ...	2005	3315051
evaluation of a program to teach health professionals to search medline.	this study analyzes the search behavior of end users who had taken a class in searching medline on the national library of medicine's medlars system. of the class alumni, 58% obtained passwords. most of these were still conducting their own searches twelve to eighteen months later. telephone interviews and search observations indicated that these end users were satisfied with their results and felt they had mastered the basic mechanics of searching. however, appropriate use of explodes and subhe ...	2005	3315051
antimicrobial activity of tertiary amine covalently bonded to a polystyrene fiber.	tertiary amine was covalently bonded to a polystyrene fiber and examined for antibacterial activity. the tertiary amine covalently bonded to a polystyrene fiber (taf) showed a high antimicrobial activity against escherichia coli. taf exhibited a stronger antibacterial activity against gram-negative bacteria (e. coli, pseudomonas aeruginosa, klebsiella pneumoniae, salmonella typhimurium, and serratia marcescens) than against gram-positive bacteria (staphylococcus aureus and streptococcus faecalis ...	1987	3314703
immunoglobulin replacement therapy.		2012	3314655
[basic factors in the pathogenicity of vibrio cholerae and their genetic control].		1987	3314272
[superselective angiography as a therapy control of femur head necrosis treated with a vascular pedicled pelvic bone graft].	this is a report of special operative therapy of idiopathic necrosis of the femoral head. this is based on the idea, that the necrosis of the femoral head is caused by an occlusion of the arteries of the femoral head, especially the arteria circumflexa femoris medialis. the necrotic area of the femoral head is filled up with a pedicle bone graft, which is apart from the spina iliaca and supplied from the art, circumflexa ilium profunda. from a total of 28 superselective angiographies of the arte ...	2012	3314217
[clinical diagnostic strategy in rheumatology].	the diagnosis of rheumatic diseases should follow a pattern of stages, the first comprising family case history, the case history of the patient and basic physical examinations. the second stage should include x-ray examination and basic or, if necessary, more extensive laboratory tests and simple synovia analysis. the third stage would then incorporate articular biopsy, arthroscopy, different biopsies outside the joint, isotope examination, electromyography, thermography, arthrosonography, comp ...	2012	3314205
[berolina iubilans: berlin physicians as halle doctoral candidates (i): johann carl wilhelm moehsen (1722-1795), halle doctoral candidate of 1742].	the celebration of the 750th anniversary of the city of berlin gave rise to remember life and work of several physicians who after their graduation at halle university set up their practice in berlin and here performed remarkable accomplishments in various fields. one of these representatives of an ars medica berolinensis is johann carl wilhelm moehsen (1722-1795), graduated at halle university in 1742, a polyhistor, who dealt with several subjects and with his regional-historical studies initia ...	2012	3314202