Publications

structural basis of the subtype selectivity of muscarinic antagonists: a study with chimeric m2/m5 muscarinic receptors.	the five muscarinic receptors (m1-m5), although structurally closely related, can be distinguished pharmacologically by the use of subtype-selective ligands. various tricyclic muscarinic antagonists, including the af-dx derivative aq-ra 741 and the alkaloid himbacine, for example, have been shown to display up to 200-fold higher affinities for m2 and m4 than for m5 receptors. on the other hand, antagonists such as sila-hexocyclium and the pirenzepine derivative uh-ah 37 exhibit lower affinities ...	2006	1538713
abpi for vein graft surveillance.		2006	1489446
outcome in the chronic fatigue syndrome.		2006	1392899
[letter: exertion asthma].		2005	1183343
[letter: striae following corticoid therapy].		2005	1169142
transfer of toxin susceptibility to plant protoplasts via the hemlmintosporoside binding protein of sugarcane.		1975	1169066
erythema gyratum atrophicans transiens neonatale.	an unknown dermatosis was observed in an infant girl. during the newborn period, she had a generalized, patchy, erythematous eruption of about 60 round erythematous patches on the trunk, thighs, head, labial mucosa, and palate. after a few weeks, the lesions became whitish, atrophic, and depressed, and they were surrounded by an erythematous and slightly infiltrated border, which was occasionally lobulated. histologically, the lesions demonstrated a thin epidermis overlying an edematous dermis. ...	2005	1169042
intrathoracic pressure as a tourniquet technic to tamponade bleeding esophageal varices.	the authors' report observations on 79 cases of esophagovariceal bleeding in which ten cases were subjected to an intrathoracic tourniquet maneuver of increasing intrathoracic pressure. all esophagovariceal bleeding ceased following the maneuver. an established maneuver safety limit (holding mean transmural cvp to no higher than 4.0 cm h2o) insured cardiac output maintenance and guaranteed against maneuver-generated morbidity. the authors conclude the cessation of the bleeding from esophageal va ...	2005	1087531
urease assay and urease-producing species of anaerobes in the bovine rumen and human feces.	a growth medium and test were developed for rapid detection of urease in fermentative anaerobic bacteria. using nonselective rumen fluid roll-tube agar medium and the new test, it was confirmed that peptostreptococcus productus is often the most numerous urease-forming species in human feces. also, some fecal strains of ruminococcus albus, clostridium innocuum, and clostridium beijerinckii produced urease. single strains of fusobacterium prausnitzii, coprococcus catus, and streptococcus mitis th ...	1977	879770
interactions of folch-lees proteolipid apoprotein with planar lipid bilayers.	water-soluble folch-lees proteolipid apoprotein from bovine cns white matter induces a voltage-dependent conductance in black lipid membranes. na+ is required for the induced conductance change but the established conductance has very low ionic selectivity. the induced conductance fluctuates with a minimum amplitude of 10(-11)--10(-10) mho. the magnitude of the conductivity change is dependent on protein concentration and on the composition of lipid bilayers. at a fixed voltage the induced condu ...	1979	522128
rehabilitation counselor and vocational evaluator competencies.		2004	522113
incidence and pathological features of spontaneous tumors in athymic nude mice.	systematic observation of 1141 nude mice (swiss background [corrected] strain) that received human tumor transplants revealed 24 spontaneous tumors, 18 of lymphoreticular origin and 6 pulmonary adenomas. spontaneous tumors were seen at an average age of 9.1 months, and 22 of the tumors were seen only in that fraction of our group (324 mice) surviving for 5 months or more (22 of 324 x 100 = 6.8%). transplantation of these tumors to other nude mice was successful in three of five cases. mice trans ...	1979	427772
soft tissue damage in war injuries of the upper extremity with special reference to tendons and nerves.		2004	375311
characterization of the glucagon receptor in a pheochromocytoma.	glucagon activated adenylate cyclase in a homogenate of a pheochromocytoma over the concentration range 1 times 10 minus 8m to 1 times 10 minus 6m. several other hormones including adrenocorticotropin, thyrotropin, parathyroid hormone and histamine were without effect. the tumor glucagon receptor was characterized and found to be similar in several ways to the glucagon receptor previously reported in normal tissue such as liver and heart. one, the receptor specifically bound 125-i-glucagon. two, ...	2003	165216
reversible hypothyroidism in growth hormone-deficient children treated with human growth hormone.	six children with human growth hormone (hgh) deficiency became hypothyroid during the course of their therapy with hgh. this was accompanied by a decreasing growth rate, clinical symptoms of hypothyroidism and decreased serum t4 concentrations. three of the 6 patients returned to the euthyroid state, both clinically and biochemically, with cessation of hgh therapy, and reinstitution of hgh precipitated hypothyroidism again in 2 of the three. the patients who remained hypothyroid have evidence of ...	1975	165211
[combined treatment of rheumatological patients at a health resort].		2003	154775
lysergic acid diethylamide: evidence for stimulation of pituitary dopamine receptors.	lysergic acid diethylamide (lsd), 0.05 mg/kg and 0.20 mg/kg, significantly decreased plasma prolactin (prl) levels in male rats. lsd, 0.20 mg/kg, also inhibits the increase in plasma prl levels produced by chlorpromazine (cpz), 5 mg/kg, and alpha-methyl-paratyrosine (ampt), 50 mg/kg, both of which interfere with dopaminergic inhibition of prl secretion. lsd was more potent than methysergide, a serotonin receptor blocker, in lowering plasma prl levels and more potent than apomorphine, a known dir ...	1977	143671
[human genetics: a task for the public health service? (author's transl)].		1977	143637
letter: bromide intoxication.		2002	126712
poncimarin, a new coumarin from poncirus trifoliata l.	a new coumarinic derivative (poncimarin; c19h22o5; m.p. 140 c degrees) was isolated from unripe fruits of poncircus trifoliata l. which from spectroscopic evidences was formulated as 7-(2,3-epoxy-3-methyl butyloxy)-8-(2,3-epoxy-3-methyl butyl) coumarin.	2002	126585
[studies on the specificity of the antistreptolysin-reaction (author's transl)].		2002	126540
the applications of steroid hormone radioimmunoassays to clinical obstetrics.	this is a selective survey of recent publications dealing with theoretical and established applications of steroid hormone radioimmunoassay procedures applied to clinical obstetric investigation. this subject is reviewed in three sections: first, basic principles of steroid hormone radioimmunoassay methodology; second, steroidogenesis in normal pregnancy and its relation to patterns of steroid hormones measured in maternal and fetal circulations; third, applied steroid radioimmunoassay technolog ...	2002	126392
senator bennett: where are you? any success of p.s.r.o. will be credited to him, any failure to organized medicine.		2002	124080
[homologous transplants in the middle ear (author's transl)].	the original concept of tympanoplasty included besides the closure of the middle ear, the removal of pathological middle ear components leaving intact the functional and healthy components. the special conditions that prevail in the middle ear (aeration, absence of intrinsic trauma) allow the reconstruction of the middle ear mechanics to a great extent. animal experiments and clinical experience reveal good transplantation properties of denatured and preserved ear ossicles. they are partly repla ...	1975	123985
investigation on huntington's disease in the canadian prairies. ii. fecundity and fitness.	the reproductive performance of 157 patients with huntington's disease, their 170 normal siblings and 150 matched unrelated controls is presented. comparison with the general canadian prairie population in the appropriate age group is undertaken. patients with huntington's disease are not only more fecund than their unaffected sibs but also out-reproduce unrelated normal controls and members of the general population of corresponding age. their fitness is thus estimated to be 1.14. should the pr ...	2002	123838
immediate results of weekly fractionation in external radiotherapy.		2000	101487
an investigation of the optimal conditions for the in vivo production of immunologically sensitised rat mast cells.	experiments were designed to develop an optimal method for inducing in vivo production of sensitised peritoneal mast cells. rats of different strains were sensitised with whole egg-white and killed at suitable intervals to harvest the peritoneal mast cells. release of histamine was induced in vitro by both whole egg-white and its major protein constituents, and assayed by a standard spectrofluorometric method. wistar rats showed higher levels of sensitisation than black-hooded lister rats; it wa ...	1979	92507
["information field dental health", an integral part of continuing dental education].		2000	89765