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effect of autonomic blockade on tracheobronchial blood flow.tracheobronchial blood flow increases two to five times in response to cold and warm dry air hyperventilation in anesthetized tracheostomized dogs. in this series of experiments we have attempted to attenuate this increase by blockade of the autonomic nervous system. four groups of anesthetized, tracheostomized, open-chest dogs were studied. group 1 (n = 5) were hyperventilated for 30 min with 1) warm humid [approximately 26 degrees c, 100% relative humidity, (rh)] air followed by bilateral vago ...19873558211
voluntary hyperventilation changes recruitment order of parasternal intercostal motor units.the order of recruitment of single-motor units in parasternal intercostal muscles during inspiration was studied in normal human subjects during quiet breathing and voluntary hyperventilation. electromyograms were recorded from the second and third intercostal spaces by means of bipolar fine wire electrodes. flow at the mouth, volume, end-expired co2, and rib cage and abdominal anterior-posterior diameters were monitored. single-motor units were identified using criteria of amplitude and shape, ...19873558179
cardiogenic shock due to papillary muscle rupture in acute myocardial infarction.we report a case of papillary muscle rupture complicating acute myocardial infarction which resulted in acute cardiogenic shock. the patient underwent urgent replacement of the mitral valve and made an uncomplicated recovery.20123557718
cardiogenic shock due to papillary muscle rupture in acute myocardial infarction.we report a case of papillary muscle rupture complicating acute myocardial infarction which resulted in acute cardiogenic shock. the patient underwent urgent replacement of the mitral valve and made an uncomplicated recovery.20123557718
cell-associated hemagglutinin-deficient mutant of vibrio cholerae.cell-associated hemagglutinin-negative mutants were derived from cholera enterotoxin-negative vibrio cholerae jbk70 by tn5 mutagenesis. one of the mutants identified, sb001, was characterized in greater detail. its ability to colonize ilea of adult rabbits was determined by feeding approximately 10(8) v. cholerae to each animal. at 17 h after feeding, the numbers of viable vibrios in the ilea were determined. there was a significant, 4 log, decrease in the ability of the hemagglutinin-negative m ...19873557620
electrophysiological effects of mexiletine in patients of sinus node dysfunction and intraventricular conduction defects. 20123557516
electrophysiological effects of mexiletine in patients of sinus node dysfunction and intraventricular conduction defects. 20123557516
chronic constrictive pericarditis with rheumatic mitral stenosis: a case report. 20123557511
different susceptibilities to the formation of cholesterol gallstones in mice.in the search for an animal model of genetic determinants of cholesterol cholelithiasis, we found strain, gender and individual differences in mice. male black (c57bl6j) mice had a 50% incidence of cholesterol gallstones after they consumed lithogenic food similar to that used by tepperman et al. for 2 weeks, whereas similarly treated male agouti (cba/j) mice and females of both strains were free of gallstones. the male and female mice of both strains were fertile at 8 weeks of age, and the male ...20133557305
[methyl-prednisolone pulse therapy of recurrent peritonitis and cerebritis in systemic lupus erythematosus]. 20123557214
metabolism of 25-hydroxycholecalciferol in a teleost fish, the rainbow trout (salmo gairdneri).plasma concentrations of vitamin d3 (cholecalciferol) metabolites have been studied in rainbow trout (salmo gairdneri) adapted to varying environmental calcium concentrations in both fresh water and artificial seawater, and in natural seawater. in vivo, intraarterial injection of tritiated 25-hydroxycholecalciferol was followed by its transformation to a number of metabolites including compounds that cochromatographed on high performance liquid chromatography (hplc) with 1,25-dihydroxycholecalci ...20133557076
correlation between anorectic potency and affinity for hypothalamic (+)-amphetamine binding sites of phenylethylamines.the potencies of a number of phenylethylamines and related compounds to inhibit food intake were compared with their relative affinities for hypothalamic (+)-amphetamine binding sites in vitro. there was a positive correlation (r = 0.78, p less than 0.001, n = 19) between potencies of these compounds to inhibit food intake and their potencies to inhibit [3h](+)-amphetamine binding. individual enantiomers of amphetamine, ephedrine, norephedrine, pseudoephedrine and norpseudoephedrine all inhibite ...19873556402
location of parathyroid adenomas by ultrasonography. 20123556154
[use of ganglioside-containing magnetic polyacrylamide sorbents for the immunoenzyme method of determining cholera enterotoxin].a variant of eia techniques for the determination of cholera enterotoxin is proposed. this method is based on the selective sorption of the toxin on ganglioside-containing magnetic granules with its subsequent detection by means of immune serum and antispecific immunoperoxidase conjugate. the proposed method permits the detection of 0.052 +/- 0.02 ng of protein of the purified toxin.19873554849
normal growth and nutrition. 20133554781
breast carcinoma metastatic to bladder.breast carcinoma metastatic to the bladder and presenting initially with urinary tract symptoms has been reported only sporadically. two cases, one unique in that the bladder was the sole site of metastasis, are reported herein, along with a review of the literature.20133554697
a randomized trial of fistulotomy in perianal abscess.in a randomized trial we compared the treatment of perianal abscess by incision only (18 patients) with that by incision followed by fistulotomy 3 days later (20 patients). all patients were observed for 12 months. there were no differences between the two groups with regard to recurrent abscess/fistula, but the fistulotomy group had a statistically significantly higher prevalence of flatus incontinence. further, fistulotomy was followed by significantly longer duration of hospitalization and by ...20123554492
pre- and postoperative therapy in cataract extraction.this review is an update on the subjects directly or indirectly concerning pre- and postoperative therapy in cataract extraction. topics were selected from those which the authors thought to be significant mainly from the clinical point of view. the review covers antiprostaglandins therapy, intraocular lens, nd-yag laser and others. the authors briefly summarize the latest trends in the above topics and give critical comments.20133554089
nutrition classics. the journal of nutrition, volume 91, 1967: the paths to the discovery of vitamins a and d. by elmer verner mccollum. 20133554022
the role of the ileum in food intake regulation. 20133554018
muscarine, imidazole, and peptide alkaloids, and other miscellaneous alkaloids. 20133554014
calcitonin gene-related peptide in the ventral tegmental area: selective modulation of prefrontal cortical dopamine metabolism.the distribution of calcitonin gene-related peptide (cgrp) in the a10 dopamine (da) cell group region of the ventral tegmental area (vta) of the rat was examined using immunohistochemical techniques. cgrp-like immunoreactivity was localized to axons innervating the rostral and dorsal vta. direct administration of cgrp to the vta of the rat resulted in a dose-related increase in da utilization in the medial prefrontal cortex, but not other mesocortical, mesolimbic, or striatal da terminal field r ...19873554009
co-distribution of neuropeptide y and its c-terminal flanking peptide in the brain and pituitary of the frog rana ridibunda.by means of the peroxidase-anti-peroxidase technique, the distribution of neuropeptide tyrosine (npy) and its c-terminal flanking peptide (c-pon) has been studied on serial sections of the brain and pituitary of the frog rana ridibunda. throughout the brain, npy and c-pon-immunoreactive perikarya exhibited a remarkable co-distribution. these two peptides were found to be co-located within the same cell bodies in various brain regions including the dorsal and ventral pallium, the dorsal and ventr ...20133554008
the morphology and distribution of serotonin-like immunoreactive fibers in the cat dorsal column nuclei.fibers showing serotonin-like immunoreactivity (5-ht-li) are demonstrated in the gracile, cuneate and external cuneate nuclei of the cat using avidin-biotinylated horseradish peroxidase and indirect fluorescence immunohistochemical methods. 5-ht-li fibers are located in all cytoarchitectural subdivisions of the gracile and cuneate nuclei but are restricted to the medial half of the external cuneate nucleus. in all nuclei, 5-ht-li fibers consist of long, varicose strands showing a wide range in t ...19873554006
mutation frequency decline in escherichia coli b/r after mutagenesis with ethyl methanesulfonate.nonsense-defective auxotrophic strains of escherichia coli b/r were used to study mutation frequency decline (mfd) after mutagenesis with ethyl methanesulfonate (ems). the mutation frequencies for prototrophic revertants that were either converted or de novo glutamine trna suppressor mutations declined as treated auxotrophic parental cells were incubated with glucose but without required amino acids (a condition typically producing mfd). the decline for converted suppressor mutations was more ra ...19873553916
assay for heat-labile escherichia coli enterotoxin using sandwich erythroimmunoassay.we investigated the possibility of using a sheep erythrocyte-antibody conjugate as reagent in a sandwich erythroimmunoassay (seria) procedure to detect and titrate escherichia coli heat-labile enterotoxin (lt) with the naked eye. in this assay, which is based on the immunological similarity between vibrio cholerae toxin (ct) and lt, rabbit anti-ct igg was used as immunosorbent, and sheep erythrocytes, sensitized with the rabbit anti-ct antibodies, were used as indicator. the sensitivity of the t ...19873553884
detection of t. cruzi antigens reactive with igg antibodies from patients with chronic chagas' disease. 19863553838
the role of naltrexone in the management of drug abuse. 20133553834
discotest. 20133553829
acute hepatic failure due to plasmodium falciparum liver injury.nine patients with acute liver failure due to plasmodium falciparum liver injury admitted to the rajgarhia liver unit of the all-india institute of medical sciences during 1982-84 are presented. the liver was palpable in all the patients, and eight had splenomegaly. investigations revealed mild to moderate abnormality in liver function tests. all were negative for the markers of acute infection due to hepatitis a and b viruses. blood film examination showed p. falciparum alone in seven and along ...19863553821
host-pathogen interaction--new in vitro drug test systems against mycobacterium leprae--possibilities and limitations. 19863553811
induction of protective immunity to malaria. 19863553798
charles-marie de la condamine: early advocate of inoculation for smallpox. 20133553758
cardiac xenotransplantation in primates.successful cardiac xenotransplantation would alleviate the severe shortage of donor organs that presently limits the availability of cardiac transplantation. early attempts at human xenotransplantation achieved minimal success. however, the effectiveness of cyclosporine in nonhuman xenotransplant models has received little experimental investigation. we have therefore studied the effect of cyclosporine-based immunosuppression in primate cardiac xenograft models using cynomolgus monkey donors and ...19873553747
a transferable resistance plasmid in vibrio cholerae and escherichia coli isolated from the same patient. 19863553305
evaluation of immuno-dot-blot assay for detection of cholera-related enterotoxin antigen in salmonella typhimurium.twenty-five strains of salmonella typhimurium isolated in india were examined for the presence of cholera/coli-related enterotoxin antigen by a previously described latex particle agglutination test and by a newly developed immuno-dot-blot test using immunopurified goat antibody against the cholera-related enterotoxin isolated from an escherichia coli strain of human origin. the immuno-dot-blot assay could detect 0.02 ng of purified enterotoxin. the amount of toxin antigen detected varied widely ...19873553233
human skin chymotrypsin-like proteinase chymase. subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans.the subcellular localization of human skin chymase to mast cell granules was established by immunoelectron microscopy, and binding of chymase to the area of the dermo-epidermal junction, a basement membrane, was demonstrated immunocytochemically in cryosections incubated with purified proteinase prior to immunolabeling. because heparin and heparan sulfate proteoglycans are major constituents of mast cell granules and basement membranes, respectively, the ability of chymase to bind to glycosamino ...19873553192
clinical and experimental aspects of single-lung transplantation.recent progress in immunosuppressive therapy for lung transplantation, improvements in surgical technique, advances in lung preservation methods, and appropriate management of cadaver organ donors have all improved the prospects for lung transplantation as a feasible therapeutic procedure for selected patients with end-stage pulmonary disease. the major limiting factor in the application of this operation will be the scarcity of good lung donors.20133553081
elimination of 131i in meadow voles (microtus pennsylvanicus) measured by whole-body gamma spectrometry. 19873553074
protective efficacy in humans of killed whole-vibrio oral cholera vaccine with and without the b subunit of cholera toxin.natural protection from cholera is associated with local intestinal antibacterial and antitoxic antibodies, which appear to act synergistically. although current parenteral cholera vaccines offer insufficient protection, new vaccines administered orally have more promise. killed vibrio cholerae, alone or given with the b subunit of cholera toxin, was evaluated in adult volunteers. vaccinees, who received three doses of either vaccine, and unvaccinated controls ingested 10(6) v. cholerae organism ...19873552989
extrarenal scintigraphic aspects of kidney transplant scans obtained with 99mtc-dtpa.in a retrospective study, 300 scans obtained with 99mtc-dtpa of 100 kidney transplant recipients were studied. the aim was to look for extrarenal scintigraphic aspects encountered specifically in renal transplant scintigraphy and to determine whether some of these phenomena could interfere with adequate interpretation. the most important phenomena seen were radioactivity in the uterus and a cold spot in the pelvis minor caused by a urine filled bladder. if the phenomena that can be encountered a ...19873552685
iga nephropathy in korea: a morphological and clinical study.iga nephropathy (iga n) is the most common type of primary glomerulonephritis (27.5%) in south korea and leads to renal failure in a significant number of cases. to evaluate the possible prognosticators of this disease, renal biopsy material from 142 korean patients with iga n was studied by light-, electron- and immunofluorescent microscopy, and a clinicopathologic correlation was made. modified classification of meadow et al. [1972] for henoch-schoenlein nephritis was adopted for the histologi ...20133552343
humoral immune function in severe, active rheumatoid arthritis.peripheral blood mononuclear cells (pbmc) from 30 patients with definite or classic active rheumatoid arthritis who were on no remittive drugs were studied for spontaneous and pokeweed mitogen (pwm)-stimulated immunoglobulin plaque-forming cell frequency (igpfc), spontaneous igm-rheumatoid factor (igm-rf) secretion, and in vitro proliferative responses to soluble recall antigens. rheumatoid spontaneous total (igg + igm + iga) igpfcs were higher than those of normal controls when assayed after 7 ...20133552341
failure of klebsiella pneumoniae antibodies to cross-react with peripheral blood mononuclear cells from patients with ankylosing spondylitis.cross-reactivity between antibodies to 2 strains of klebsiella pneumoniae (k43 and f77) and the peripheral blood lymphocytes of patients with ankylosing spondylitis (as) was examined in 3 separate antibody binding and cytotoxicity assays. using k pneumoniae antisera in a chromium release cytotoxicity assay, we found no difference in the reactions of cells from as patients and those from control subjects. this result contrasts with the results of previous studies. similarly, using an enzyme-linke ...19873551965
nocardia asteroides as a cause of corneal ulcer. case report. 19873551895
antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (bw a509u).the thymidine analog 3'-azido-3'-deoxythymidine (bw a509u; azidothymidine [azt]) had potent bactericidal activity against many members of the family enterobacteriaceae, including strains of escherichia coli, salmonella typhimurium, klebsiella pneumoniae, shigella flexneri, and enterobacter aerogenes. azt also had bactericidal activity against vibrio cholerae and the fish pathogen vibrio anguillarum. azt had no activity against pseudomonas aeruginosa, gram-positive bacteria, anaerobic bacteria, m ...19873551832
respiratory responsiveness in male alcoholics after withdrawal.peripheral and central chemosensitivity were assessed in eight abstinent male alcoholic patients and in seven healthy normal male subjects. hypoxic rebreathing (15% o2, 7% co2) was used to stimulate the peripheral and central chemoreceptors together. hyperoxic rebreathing (93% o2, 7% co2) was used to examine the central chemoreceptor response independently of the peripheral chemoreceptors. minute ventilation was examined in relation to end-tidal paco2 under the two conditions. neither peripheral ...20123551663
the effect of calcium on renin, aldosterone and prostaglandin release. 20113551541
[morphometric comparison of 2 populations of tarebia granifera (lamarck)(mollusca: prosobranchia)]. 19863550952
[morphometric comparison of 2 populations of tarebia granifera (lamarck)(mollusca: prosobranchia)]. 19863550952
acute radiation-induced vomiting in area postrema-ablated cats.a dose-response relationship was established in normal unanesthetized cats for emetic incidence, latency to onset of vomiting, and duration of emetic activity over a period of 24 h after whole-body exposure to 60co radiation at selected doses between 7.5 and 90 gy. each episode of vomiting, i.e., retching and expulsion, was recorded oscillographically as its characteristic intrathoracic pressure waveform by means of a catheter inserted some days before into the superior vena cava. the gamma-radi ...19873550870
acute radiation-induced vomiting in area postrema-ablated cats.a dose-response relationship was established in normal unanesthetized cats for emetic incidence, latency to onset of vomiting, and duration of emetic activity over a period of 24 h after whole-body exposure to 60co radiation at selected doses between 7.5 and 90 gy. each episode of vomiting, i.e., retching and expulsion, was recorded oscillographically as its characteristic intrathoracic pressure waveform by means of a catheter inserted some days before into the superior vena cava. the gamma-radi ...19873550870
increased insulin secretion in response to glucose in isolated islets of langerhans from bile duct-occluded rats.in a recent study, it was demonstrated that following i.v. injection of glucose, plasma insulin levels increased more in cholestatic rats than in control rats. this could theoretically be due to either a potentiated insulin secretion or an inhibited liver extraction of insulin in cholestatic rats. in the present study, we report the influence of obstructive jaundice on insulin secretion from isolated islets of langerhans 3 weeks after bile duct occlusion or sham operation in rats. we found that ...19863550788
[molecular defects of coagulation factors and of the fibrinolytic system associated with thromboembolism].some molecular defects of components of the coagulation or fibrinolytic system are associated with thromboembolism. one possibility is that physiologic inhibitors of the coagulation system have an abnormal function e.g. protein c, protein s, antithrombin iii and cofactor ii of heparin. also a hindered activation of the fibrinolytic system may predispose to thrombosis; the impaired activation may be due to deficient synthesis and/or release of tissue-plasminogen activator, an increased level of i ...20133549955
randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic escherichia coli and vibrio cholerae.to evaluate the antisecretory activity of berberine sulfate (bs), we studied 165 adult patients with acute diarrhea due to enterotoxigenic escherichia coli (etec) and vibrio cholerae in randomized controlled trials. in patients with etec diarrhea who received 400 mg of bs in a single oral dose, the mean stool volumes were significantly less than those of the controls during three consecutive 8-hr periods after treatment (p less than .05). at 24 hr after treatment, significantly more patients who ...19873549923
oral ciprofloxacin in the treatment of uncomplicated gonococcal urethritis in men.two hundred and seventy-one male patients suffering from uncomplicated gonococcal urethritis were treated in an open randomized study with either 250 mg (121 patients) or 500 mg (150 patients) single oral doses of ciprofloxacin. the efficacy of treatment was verified on the third day by direct examination of urethral swabs in 91 patients and by culture and direct microscopic examination in 180 subjects. cure rates were 100% in the 500 mg group and 96.6% in the 250 mg treated patients. no side ef ...20123549010
rearrangement of the vimentin cytoskeleton during adipose conversion: formation of an intermediate filament cage around lipid globules.during adipose conversion of murine 3t3-l1 cells, the arrangement of vimentin intermediate filaments (ifs) changes from an extended fibrillar state to a complex cage formation tightly associated with the forming lipid globules. the fully developed cage complex surrounding the lipid globule consists of a monolayer of groups of regularly spaced vimentin ifs that in turn is closely ensheathed by a special endoplasmic reticulum cisterna. the same if cage is also seen in other adipocytes in culture a ...20123548999
rearrangement of the vimentin cytoskeleton during adipose conversion: formation of an intermediate filament cage around lipid globules.during adipose conversion of murine 3t3-l1 cells, the arrangement of vimentin intermediate filaments (ifs) changes from an extended fibrillar state to a complex cage formation tightly associated with the forming lipid globules. the fully developed cage complex surrounding the lipid globule consists of a monolayer of groups of regularly spaced vimentin ifs that in turn is closely ensheathed by a special endoplasmic reticulum cisterna. the same if cage is also seen in other adipocytes in culture a ...20123548999
experience with bone marrow transplantation for severe aplastic anemia and leukemia. two years experience with 31 patients in zagreb (yugoslavia).since 1983, twelve patients with severe aplastic anemia and nineteen patients with leukemia were treated with bone marrow transplantation. six patients with severe aplastic anemia are still alive at 300 to 1,210 days after transplantation, and twelve patients with leukemia are alive at 199 to 671 days. the incidence of gvhd was relatively high (60%). bacterial infections were the main causes of death.20133548836
update on lung disease in coalminers. 20133548801
protein loading test before and after kidney donation.renal response to a 60 g protein load was investigated in 33 normal subjects in terms of creatinine clearance and urinary protein excretion. the test was repeated in 10 of these subjects six months after donor nephrectomy. creatinine clearance and urinary protein excretion increased significantly one and two hours after ingestion of the protein load (in the form of casein mixture); the change in urinary protein excretion correlated significantly with the change in creatinine clearance (p less th ...20123548685
bowel sounds during intermittent positive pressure ventilation. 20123548476
bowel sounds during intermittent positive pressure ventilation. 20123548476
adult respiratory distress syndrome. a live e coli septic primate model. 19873548404
[immunofluorescence method of detecting cholera enterotoxin].the quantitative immunofluorescent assay for the determination of cholera enterotoxin is proposed. the assay is based on the selective sorption of cholera enterotoxin by gangliosides incorporated into polyacrylamide granules. the preliminary treatment of gangliosides with neuraminidase enhances the sensitivity of this assay. the assay permits the detection of cholerigen in an amount of 20 ng.19863548172
[phagocyte chemiluminescence during kidney graft rejection in a dog model]. 19863548112
[phagocyte chemiluminescence during kidney graft rejection in a dog model]. 19863548112
lysosomal enzyme replacement in neural tissue by allogeneic bone marrow transplantation following total lymphoid irradiation in canine fucosidosis. 19873547950
red cell alloantibodies produced after bone marrow transplantation.this article describes the production of red cell alloantibodies in 13 of 150 patients after bone marrow transplantation. new alloantibodies appeared 12 days to 11 months after the transplantation. the specificities of these antibodies were anti-n, -jka, -e-like, -kell-like, -m, -leb, -hl, -h and -a1. the posttransplantation production of antibody could be due to either the transfusion of mature lymphocytes along with the marrow, the ability of the grafted immune system to produce alloantibodies ...20123547785
functional image data acquisition and processing.in the production of functional images certain hardware and software considerations are necessary for the rapid and accurate determination of kinetic parameters. the advent of the digital scintillation camera has made available increased accuracy of quantitation and ease of image handling, although its integrated computer system may not be optimal for program development presently. to reduce the deleterious effects of poisson noise on parameter estimation, the single or multiple application of e ...20133547664
a new elisa test for hiv antibodies using a bacterially produced viral env gene product.screening tests for antibodies to the human immunodeficiency virus (hiv), based on the indirect elisa principle using viral preparations as antigen, yield a substantial number of false-positive and false-negative results. these failures are due to the lack of certain viral polypeptides or contaminating cellular polypeptides in viral preparations. therefore, the accuracy of the screening tests should be improved by using highly purified, synthetic viral antigens. with establishment of such an eli ...19873547057
[phagocytes in the host defense mechanism]. 20123546777
predation on rhodnius prolixus (hemiptera: reduviidae) by the spider theridion rufipes (araneida: theridiidae). 19873546692
evolutionary origin of pathogenic determinants in enterotoxigenic escherichia coli and vibrio cholerae o1.three families of the evolutionarily related pathogenic determinants in enterotoxigenic escherichia coli and vibrio cholerae o1, a family of cholera enterotoxin (ct) and heat-labile enterotoxin (lt) including ct, lth, and ltp, a family of heat-stable enterotoxin i (sti) including stia and stib, and a family of k88 enteroadhesion fimbriae including k88ab, k88ac, and k88ad were analyzed for synonymous (silent) nucleotide substitutions by using the gene nucleotide sequences of earlier reports and t ...19873546273
the comparative activity of pefloxacin, enoxacin, ciprofloxacin and 13 other antimicrobial agents against enteropathogenic microorganisms.in this study, we compared the activity of pefloxacin, enoxacin and ciprofloxacin against 269 enteropathogenic strains (campylobacter jejuni, enteropathogenic escherichia coli, salmonella typhi, shigella spp., vibrio cholerae and yersinia enterocolitica) with that of rosoxacin, flumequin, nifuroxazide, erythromycin, chloramphenicol, ampicillin, cefotaxime, tetracycline, amikacin, netilmicin, sulfamethoxazole, trimethoprim and co-trimoxazole. pefloxacin, enoxacin and ciprofloxacin were always amo ...19863546145
the use of an oral prostaglandin inhibitor following splintage in fractures of the distal radius--a prospective trial.a prospective, double-blind, controlled trial is reported in which oral diclofenac, a prostaglandin inhibitor, was given for 1 week immediately following the removal of splintage for fracture of the distal end of the radius. the patients who received the prostaglandin inhibitor had less pain, a more rapid recovery of range of movement and a stronger grip than those who received a placebo.20123546124
the use of an oral prostaglandin inhibitor following splintage in fractures of the distal radius--a prospective trial.a prospective, double-blind, controlled trial is reported in which oral diclofenac, a prostaglandin inhibitor, was given for 1 week immediately following the removal of splintage for fracture of the distal end of the radius. the patients who received the prostaglandin inhibitor had less pain, a more rapid recovery of range of movement and a stronger grip than those who received a placebo.20123546124
gastric inhibitory polypeptide and the entero-insular axis in streptozotocin diabetic mice.the function of the entero-insular axis and abnormalities of circulating gastric inhibitory polypeptide (gip) were examined in mice for 40 days after induction of streptozotocin diabetes. compared with untreated controls, streptozotocin diabetic mice exhibited marked hyperglycaemia and hypoinsulinaemia, with impaired body weight gain, lipoatrophy, hyperphagia, intestinal hypertrophy, polydipsia and renal hypertrophy. plasma gip concentrations were elevated in fed but not fasted streptozotocin di ...20123545933
control of non-insulin dependent diabetes is not correlated with endogenous insulin secretion.c-peptide was determined in seventy-one patients with non-insulin dependent diabetes mellitus (niddm) before and after a standard 500-calorie breakfast. whereas in the normal-weight and obese controls the fasting c-peptide was 1.7-2.2 and postprandial maximum 6.0-6.6 ng/ml, in niddm the fasting level was only 2.4 +/- 1.5 ng/ml in spite of hyperglycemia of 234 mg/dl, and increased after breakfast to only 3.9 +/- 1.9 ng/ml. fasting and postprandial levels of c-peptide correlated among themselves b ...20123545932
[lymphomatoid papulosis]. 20123545029
[lymphomatoid papulosis]. 20123545029
role of apolipoprotein e in lipoprotein metabolism. 19873544762
when is drug treatment indicated in mild hypertension? 20133544075
culture conditions for stimulating cholera toxin production by vibrio cholerae o1 el tor.a method that stimulates cholera toxin (ct) production by vibrio cholerae o1 biotype el tor (el tor vibrios) to the level of several micrograms per ml in the culture fluid was established. such a large amount of ct was obtained by the following method: el tor vibrios were cultured in aki medium (1.5% bacto peptone, 0.4% yeast extract-difco, 0.5% nacl, 0.3% nahco3) at 37 c for 4 hr in a stationary test tube and then for 16 hr in a shaken flask, with inoculum sizes of 10(5) to 10(7)/ml. with this ...19863543624
a phase i-ii trial of carboplatin and 5-fluorouracil combination chemotherapy in advanced carcinoma of the head and neck.twenty-nine patients with recurrent or advanced, incurable head and neck cancer were entered into a phase i-ii trial of carboplatin in combination with 5-fluorouracil (5-fu), 1,000 mg/m2/d continuous intravenous (iv) infusion for five days every 28 days. the initial dose of carboplatin was 300 mg/m2 for patients with karnofsky performance scores greater than or equal to 70%, and 240 mg/m2 for patients with scores of 50% to 60%. subsequent doses were modified to achieve grade 2 myelo-suppression: ...20123543242
measurements of prednisolone and some of its metabolites, in urine of patients after orthotopic liver transplantation, as a means of monitoring prednisolone absorption.in patients who had undergone orthotopic liver transplantation, malabsorption of prednisolone or increased metabolism of prednisolone was suspected. in order to rule out this possibility, urinary prednisolone, and some of its metabolites, viz prednisone and 6 beta-hydroxyprednisolone, were determined by means of a gas chromatographic assay. to evaluate this assay aliquots of a pooled urine from several of our patients were analysed in multiplicate (n = 10). mean prednisone, prednisolone and 6 be ...20123543199
[acute fatty liver of pregnancy].the authors analyse 115 cases of acute fatty liver of pregnancy, proven histologically. characteristics of the condition is the finding of central nuclei in the hepatocytes containing microvesicular droplets. the disease occurs more frequently in primiparous women (54 per cent) and usually occurs in the third trimester of the pregnancy. a pre-icteric phase usually precedes the jaundice and during that time there is usually vomiting and/or nausa with abdominal pain or anarexia. in 92 per cent of ...20123543102
[review of the principal dental implants used in quebec]. 20133543082
phosphorylation, glycosylation, and proteolytic activity of the 52-kd estrogen-induced protein secreted by mcf7 cells.we have studied the posttranslational modifications of the 52-kd protein, an estrogen-regulated autocrine mitogen secreted by several human breast cancer cells in culture (westley, b., and h. rochefort, 1980, cell, 20:353-362). the secreted 52-kd protein was found to be phosphorylated mostly (94%) on high-mannose n-linked oligosaccharide chains, and mannose-6-phosphate signals were identified. the phosphate signal was totally removed by alkaline phosphatase hydrolysis. the secreted 52-kd protein ...19873543022
phosphorylation, glycosylation, and proteolytic activity of the 52-kd estrogen-induced protein secreted by mcf7 cells.we have studied the posttranslational modifications of the 52-kd protein, an estrogen-regulated autocrine mitogen secreted by several human breast cancer cells in culture (westley, b., and h. rochefort, 1980, cell, 20:353-362). the secreted 52-kd protein was found to be phosphorylated mostly (94%) on high-mannose n-linked oligosaccharide chains, and mannose-6-phosphate signals were identified. the phosphate signal was totally removed by alkaline phosphatase hydrolysis. the secreted 52-kd protein ...19873543022
human pituitary tryptase: molecular forms, nh2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.a human pituitary-derived serine protease, immunologically identical to human lung tryptase (smith, t. j., hougland, m.w., and johnson, d.a. (1984) j. biol. chem. 259, 11046-11051), was found immunohistochemically to be associated with mast cells present in pituitary connective tissue. western blotting combined with sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated the presence of multiple forms: a major mr 36,300 form and three minor forms with mr 32,400, 33,400, and 34,600. t ...19873543004
human pituitary tryptase: molecular forms, nh2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.a human pituitary-derived serine protease, immunologically identical to human lung tryptase (smith, t. j., hougland, m.w., and johnson, d.a. (1984) j. biol. chem. 259, 11046-11051), was found immunohistochemically to be associated with mast cells present in pituitary connective tissue. western blotting combined with sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated the presence of multiple forms: a major mr 36,300 form and three minor forms with mr 32,400, 33,400, and 34,600. t ...19873543004
comparative study of vibrio cholerae non-o1 protease and soluble hemagglutinin with those of vibrio cholerae o1.protease and soluble hemagglutinating activities produced by a non-o1 vibrio cholerae strain isolated from a patient with diarrhea were compared with similar activities produced by v. cholerae o1. the soluble protease activities were indistinguishable in heat stability, immunodiffusion, inhibition by antiserum, and electrophoretic analysis. on the other hand, the soluble hemagglutinating activities of both strains were not completely identical. the hemagglutinating activity of the non-o1 v. chol ...19873542835
a case study of hmo medicare enrollment. 20133542731
clinical overview of alpha interferon. studies and future directions.the clinical development of the alpha interferons has now progressed through initial phase i and ii trials into extensive controlled clinical trial designs. alpha interferon has been a prototype of other biological agents that are now in clinical development. these agents operate through fundamentally different mechanisms of action than conventional chemotherapy and have produced a unique profile of side effects as well as response patterns. time to response is generally longer than with chemoth ...20133542185
[efficacy and tolerance of a bepridil challenge dose. a double-blind multicenter study]. 20123541768
[effect of intestinal microflora on the pathogenesis of cholera intoxication].germ-free minipigs, previously treated with bacteroids, develop cholinergic reaction after the intragastric administration of vibrio cholerae exotoxin. the intensity of this reaction, disturbances in homeostasis, and the character of morphological changes depend on the dose of choleragen, the bacteroid strain, and the presence of the concomitant (escherichia coli) and residual microflora in the intestine.19863541468
unique forms of the abl tyrosine kinase distinguish ph1-positive cml from ph1-positive all.in the philadelphia chromosome (ph1) of chronic myelogenous leukemia (cml), the c-abl gene on chromosome 9 is translocated to bcr on chromosome 22. this results in the expression of a chimeric bcr-abl message that encodes the p210bcr-abl tyrosine kinase. the cells of 10% of acute lymphocytic leukemia patients (all) carry a cytogenetically similar ph1 translocation. we report that ph1-positive all cells express unique abl-derived tyrosine kinases of 185 and 180 kilodaltons that are distinct from ...20123541203
assays of pancreatic b cell secretory products: utility in investigative and clinical diabetology. 20133541145
clinical and immunological results of corneal allograft rejection.of 111 episodes of graft rejection in 66 patients, 62 responded to therapy with graft clearing (responders); 49 did not (non-responders). both groups were of similar age, sex, and etiology; both had a similar rate of glaucoma and a similar rate of previous grafting. in responders the graft reaction was shorter in duration (2.2 vs. 5.6 wks. p less than 0.005), and it was necessary to increase the number of glaucoma medications more often in non-responders compared to responders (41% vs. 19%, p le ...20123540770
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