Publications

roles of hormonal and nutritional factors in the regulation of rat liver alcohol dehydrogenase activity and ethanol elimination rate in vivo.	fasting reduced the liver alcohol dehydrogenase (adh) activity by 51% (p less than 0.001). insulin, within 2 hr, increased the adh activity found in fasted animals by 28% (p less than 0.02). insulin administration failed to stimulate the reduced adh activity in diabetic rats. however, adh activity in the diabetic-fed rats decreased by 52-54% (p less than 0.001) compared to normal-fed rats regardless of whether they were meal-fed or refed the normal chow. glucagon blocked by 15% (p less than 0.02 ...	1988	3044171
[experiences with the preventive use of aminophylline (euphylline) in apnea and periodic respiration in infants].	sleep apnea and periodic breathing in infants are the result of a mild hypoxia and they are the requirement for sids. as a results of the modern medicine each 4.-5. death is the cause of sids during the first year of life. the positive effect of theophylline on apnea of prematurity is known since 1973. we have given theophylline (euphyllin) from 1979 till 1986 to 198 premature infants with a birth weight below 2000 g for apnea prophylaxis orally in a doses of 9 mg/kg body weight per day distribu ...	2011	3043316
t and b peripheral blood lymphocytes in normal and lymphocytotic sheep.	surface immunoglobulins (sig), peanut agglutinin (pna), spontaneous erythrocyte rosette (e-rosette) and helix pomatia (hp) marker were investigated in normal and bovine leukemia virus (blv)-infected sheep. in normal sheep, 19.3% +/- 4.9 of peripheral blood lymphocytes (pbl) were sig+, whereas 58% +/- 5.69 were pna+, and 19.6 +/- 5.2 were e-rosette forming cells (e-rfc). in blv-induced lymphocytotic sheep, sig+ cells in pbl reached 59.4% +/- 15.06. in the same animals, pna bound to 20.6% +/- 9.69 ...	1987	3040327
a high-yield, high-purity elutriation method for preparing human granulocytes demonstrating enhanced experimental lifetimes.	a counterflow centrifugal elutriation procedure for preparing human granulocytes is described. this method permits isolation of 1-2 x 10(9) granulocytes with a yield of 70% +/- 7% from a unit of whole blood in 3 h. these cells are 99% +/- 1% pure and 95-99% viable. when compared to cells prepared by a conventional procedure employing hypotonic lysis to remove red cells, the elutriated cells show enhanced oxidative responses resulting from enhanced longevity. other responses including receptor-me ...	1987	3036986
communicating leveled clinical expectations to nursing students.	nurse educators agree on the need for objectives in the classroom situation and frequently communicate them in a written form. written expectations for clinical, however, are rarely given to student nurses prior to their clinical experience. clinical expectations are understood by instructors, but communicating them to students result in mixed interpretations. the article describes the development of a written method of communicating clinical expectations to solve this problem. this method corre ...	2010	3035139
regional variation in high-density lipoprotein binding to human adipocyte plasma membranes of massively obese subjects.	obesity is associated with significant changes in cholesterol and lipoprotein metabolism. high density lipoprotein (hdl) cholesterol is often reduced and adipose tissue cholesterol stores are increased in obese individuals. this prompted a study on the binding of hld fractions (hdl2 and hdl3) to adipocyte plasma membranes obtained from massively obese subjects (bmi greater than 37 kg m-2) undergoing gastroplasty. regional variation in hdl binding to these adipocyte plasma membranes was demonstra ...	1987	3032643
[immunohistological detection of antisera to casein in skin tumors].		2010	3029469
[immunohistological detection of antisera to casein in skin tumors].		2010	3029469
beta 2 microglobulin enhances the infectivity of cytomegalovirus and when bound to the virus enables class i hla molecules to be used as a virus receptor.	we have previously demonstrated that human cytomegalovirus (cmv) binds the host protein beta 2 microglobulin (beta 2m) from body fluids or from cell culture media. in this report we have examined the effect of the beta 2m on viral infectivity. we have shown that the addition of human purified beta 2m, or a fraction of foetal calf serum corresponding to bovine beta 2m, to culture medium increased the amount of infectious extracellular cmv, compared to that from cells grown in serum-free medium. m ...	1987	3029306
synthesis and antiviral evaluation of 1,4-dioxane nucleoside analogues related to nucleoside dialdehydes.	since biologically active nucleoside 2',3'-dialdehydes exist as six-membered cyclic acetals (1) in solution, we have investigated the antiviral activity of some structurally similar 1,4-dioxane nucleoside analogues. by reacting 2',3'-seconucleoside tosylates with base, the guanine (10) and adenine (18) substituted (hydroxymethyl)dioxanes have been constructed. in addition, an unusual adenine-substituted divinyl ether (22) was synthesized via a base-catalyzed, double elimination of a 2',3'-di-o-t ...	1986	3023613
immunosuppressive properties of human placenta: study of supernatants from short-term syncytiotrophoblast cultures.	using collagenase and mechanical treatment to attempt to eliminate cellular contamination such as macrophages and decidual cells, trophoblast enriched cell suspensions were isolated from the human placenta. with a view to assessing the role of trophoblast in impairing maternal rejection of the fetus, supernatants (spl4) were prepared from these placental cells after short-term culture (4 h). the immunosuppressive activity of these supernatants was studied following application to mitogen-stimula ...	1986	3023607
initiation of swimming activity by trigger neurons in the leech subesophageal ganglion. iii. sensory inputs to tr1 and tr2.	in papers i and ii of this series, we described two pairs of interneurons, tr1 and tr2, in the leech subesophageal ganglion which can trigger swimming activity in the isolated central nervous system (cns). in this paper, we describe sensory inputs to these trigger neurons from previously identified mechanosensory neurons. we found that: weak mechanical stimulation (stroking) of a body wall flap attached to a segmental ganglion in an otherwise isolated cns excites the contralateral tr1 slightly. ...	2010	3023604
initiation of swimming activity by trigger neurons in the leech subesophageal ganglion. ii. role of segmental swim-initiating interneurons.	cell tr1, a trigger neuron found in the subesophageal ganglion of the leech, hirudo medicinalis, is part of a network of subesophageal ganglion neurons which control swimming activity, and makes apparently direct connections to swim-initiating interneurons (siis; cells 204 and 205). in this study, we investigated the role of siis in swim initiation by cell tr1. we also examined how brief tr1 activity controls swim initiation at the levels of the siis and of the oscillator neurons. we found: in s ...	1986	3023603
interactions of anticancer quinone drugs, aclacinomycin a, adriamycin, carbazilquinone, and mitomycin c, with nadph-cytochrome p-450 reductase, xanthine oxidase and oxygen.	the properties of the interactions of anticancer quinone drugs, aclacinomycin a, adriamycin, carbazilquinone, and mitomycin c with nicotinamide adenine dinucleotide phosphate (nadph)-cytochrome p-450 reductase and xanthine oxidase under anaerobic and aerobic conditions were studied. km values of nadph-cytochrome p-450 reductase for these drugs were in the range of 40-227 microm, and that of deflavo xanthine oxidase in the range of 39-over 200 microm. under anaerobic conditions, when xanthine was ...	2010	3023600
hypophosphatemic rickets/osteomalacia in linear sebaceous nevus syndrome: a variant of tumor-induced osteomalacia.	a severe form of vitamin d-resistant rickets is associated with the linear sebaceous nevus syndrome. we investigated the pathophysiology underlying defective bone mineralization in two individuals and examined the effects of 1,25-dihydroxyvitamin d (1,25(oh)2d, calcitriol) therapy on the clinical and biochemical abnormalities. both patients had fasting hypophosphatemia, markedly diminished tmp/gfr, and elevated alkaline phosphase activity in the presence of normocalcemia. before treatment with c ...	2010	3023599
release of low infectivity vesicular stomatitis virus particles from tunicamycin-treated cells.	the effect of tunicamycin (tm) treatment on the production, glycosylation, morphology and infectivity of vesicular stomatitis virus (vsv) released from mouse (lb), monkey (cos-1 and vero), bovine (mdbk), hamster (bhk) and human (hela, u and gm2504) cells was investigated. the yield of vsv particles released from tm treated cells, as measured by total viral proteins, was inhibited only 2-10 fold while the infectivity of these particles was greatly reduced (10-1000 fold). the morphology of vsv par ...	1985	3023584
epstein-barr virus infections in families: the role of children with infectious mononucleosis.	we performed a prospective evaluation of epstein-barr virus (ebv) infections in 78 families with a childhood index case of ebv-infectious mononucleosis (ebv-im). during the acute index episode, adult family (household) contacts, compared with control adults, had a greater rate of oropharyngeal ebv excretion and high serum antibody responses, which suggested a recent antecedent reactivation of an old ebv infection. the increased prevalence of oropharyngeal ebv and acute serological responses foun ...	1986	3021867
significance of intracellular calcium and cyclic adenosine 3',5'-monophosphate in the mechanisms by which prostaglandins influence human sperm function.	the selective ability of pge-1 and pge-2 to enhance the capacity of human spermatozoa for hamster oocyte penetration was dependent upon high concentrations (1.7 mm) of extracellular ca2+ and a prolonged (4 h) duration of exposure, and insensitive to the ca2+ channel antagonist, verapamil. studies with the intracellular calcium indicator quin-2 indicated that exposure to pge-1 and pge-2, but not pgf-2 alpha, induced a significant rise in the levels of cytoplasmic ca2+, suggesting that an ionophor ...	1986	3016256
central nervous system lesions in suckling mice and rats inoculated intranasally with sialodacryoadenitis virus.	suckling cd-1 and cfw mice and wi wistar rats were inoculated intranasally with sialodacryoadenitis virus. in animals inoculated during the first week of life, there was an acute necrotizing encephalitis with malacia and minimal inflammatory cell response. in mice and rats which survived for up to 12 days post inoculation, loss of brain substance, gitter cells and occasionally mineralized debris were seen. viral antigen was readily demonstrated in neurons and nasal epithelium in trypsin-treated, ...	1986	3004003
effect of dibutyryl cyclic amp on morphologic features and biologic markers of a human salivary gland adenocarcinoma cell line in culture.	dibutyryl cyclic amp (db-camp) has marked effects on the growth, morphologic features, and biologic markers of a human salivary gland adenocarcinoma cell line in culture. a cell line with ultrastructure and biologic markers specific to the intercalated duct cells of human salivary glands was cultivated in the presence of db-camp. major alterations, such as process formation and expression of myofilaments and oxytocin receptor in addition to myosin and s-100 protein, were observed in those cells ...	1986	3002591
demonstration of non-degraded aleutian disease virus (adv) proteins in lung tissue from experimentally infected mink kits. brief report.	isolates of adv replicate to rather high quantities in lungs from neonatally infected mink kits. the virus was analysed for polypeptide composition, and for the first time high molecular weight polypeptides have been observed in in vivo produced advs. these polypeptides are analogous to those of in vitro produced advs. the molecular weights of the structural polypeptides of the low virulence pullman adv and the highly virulent dk and utah i isolates of adv were found to be 88kd and 78kd and in v ...	1986	3002299
[surgery in the treatment of patients with small cell lung cancer].	the data on surgical and combined treatment of 52 cases of small cell lung cancer are presented and the end results are evaluated. the findings on survival time make the case for surgery as a component of combined treatment of tumor. the best results were obtained in cases of stage i and ii tumor, absence of metastases into intrathoracic lymph nodes, tumor invasion limited to bronchopulmonary lymph nodes or the root of the lung, intermediate cell pattern of small cell lung cancer and surgery fol ...	2010	2998088
polarized plasma membrane domains in cultured endothelial cells.	to determine whether distinct plasma membrane domains exist in endothelial cells, we infected monolayer cultures of macro- and microvascular endothelial cells with enveloped rna viruses known to bud selectively from either the apical or basal surface in polarized epithelial cells. we found that vesicular stomatitis (vsv) and sendai virus emerge asymmetrically from cultured endothelial cells. this provides direct evidence for the existence of polarized plasma membrane domains in vascular endothel ...	1985	2996916
antinociceptive effect of diisopropylphosphofluoridate: development of tolerance and lack of cross-tolerance to morphine.	the irreversible cholinesterase inhibitor diisopropylphosphofluoridate (dfp) causes a naloxone-sensitive antinociceptive effect in laboratory animals. chronic treatment of male mice with dfp (2 mg/kg/day for fourteen days) rendered the animals tolerant to its antinociceptive effect. animals tolerant to dfp were cross-tolerant to the antinociception induced by the cholinergic agonists oxotremorine and nicotine, but no cross-tolerance with morphine was observed. similarly, mice made tolerant to mo ...	2010	2993935
alterations in concentrations of cyclic guanosine 3',5'-monophosphate in guinea pig urine during the development of a transplantable leukaemia.	cyclic guanosine 3',5'-monophosphate (cgmp) concentrations were measured in urine specimens from guinea pigs before and after transplantation of a leukemia. a transient increase in cgmp concentration occurred 3 days after inoculation which preceded any detectable increase in the white blood cell count. this peak in cgmp concentration was found to be very highly significant when compared with fluctuations in urinary cgmp levels in the guinea pigs from transplantation of the leukemia. inoculation ...	1985	2992765
a stable tracer technique for calcium metabolism studies.	a tracer technique using the stable isotope calcium-48 was developed to facilitate studies of human calcium metabolism. small samples of 1 ml serum were used. calcium levels were determined with good precision using neutron-activation analysis after pre-concentration of the serum calcium by oxalate precipitation. the method has sufficient sensitivity to detect induced dilutions of the tracer by administering other less costly isotopes of calcium. the ability to utilize small volumes of sample is ...	1988	2980818
new data on the acceptance of the hepatitis b vaccine by dental personnel in the united kingdom.		2010	2964251
continuous subcutaneous insulin infusion versus injection therapy: a randomized cross-over trial under usual diabetic clinic conditions.	twelve c-peptide negative insulin-dependent diabetic patients participated in a randomized cross-over study of 6 months treatment with twice or thrice daily insulin injection therapy and continuous subcutaneous insulin infusion (csii). standard, non-intensified management conditions were maintained throughout. glycosylated haemoglobin levels were similar on both regimens (9.2 +/- 0.5% versus 9.0 +/- 0.4%; csii vs injection therapy; (mean +/- sem). capillary blood glucose concentrations before br ...	2010	2962807
limited tryptic digestion of acanthamoeba myosin ia abolishes regulation of actin-activated atpase activity by heavy chain phosphorylation.	acanthamoeba myosin ia is a globular protein composed of a 140-kda heavy chain and a 17-kda light chain. it expresses high actin-activated mg2+-atpase activity when one serine on the heavy chain is phosphorylated. we previously showed that chymotrypsin cleaves the heavy chain into a cooh-terminal 27-kda peptide that can bind to f-actin but has no atpase activity and a complex containing the nh2-terminal 112-kda peptide and the light chain. the complex also binds f-actin and has full actin-activa ...	2010	2958454
[home-made simple automatic flow-time counter for viscosity measurement].		2010	2956340
contact urticaria to chlorocresol.		2010	2948766
effect of mononuclear cell factors on calcium transport in sarcoplasmic reticulum vesicles.	the effect of supernatants from cultures of mitogen-stimulated human mononuclear cells on calcium transport by sarcoplasmic reticulum was examined. calcium transport was assayed by measuring the time course of calcium accumulation by sarcoplasmic reticulum incubated with supernatants from stimulated mononuclear cells was 20% less than that by vesicles exposed to control supernatants (p less than 0.001). in contrast, no difference in calcium-dependent atpase activity was noted between vesicles in ...	1986	2946307
[septicemic campylobacteriosis after dog bite].		1986	2945190
allergy to diphenylamine from an industrial grease.		2010	2940051
[laboratory diagnosis of lysosomal storage disease (glycoproteinosis pompe's disease and gaucher disease)].		2010	2940012
[magnetic resonance and computed tomography in brain evaluation].		2009	2920680
free and sulfoconjugated catecholamines in normotensive uremic patients: effects of hemodialysis.	in 9 normotensive uremic patients undergoing chronic hemodialysis, the baseline plasma catecholamines varied widely from low-normal to very high; sulfoconjugated plasma catecholamines were constantly high. a dialysis-induced fall of all sulfated catecholamines and epinephrine was observed. norepinephrine decreased in 5 patients and increased in 4, with a strong inverse correlation between predialysis norepinephrine and delta norepinephrine (p less than 0.0001). no correlation was evident between ...	2010	2918946
ischaemic mouse thigh model for evaluation of pathogenicity of non-clostridial anaerobes.	a mouse thigh model has been devised in which the growing culture of non-clostridial anaerobe in the ischaemic tissue produces inflammatory swelling and death. the swelling of the right thigh served as an index of pathogenicity of the test strain in comparison to the negatively reacting left thigh which received injection of the control strain of bifidobacterium infantis. actinomyces naeslundii exceptionally caused death in all animals within 24 h. mortality and thigh swelling were pronounced (g ...	1989	2914729
protective role of serum antibody in immunity to chlamydial genital infection.	female guinea pigs were injected intraperitoneally with pooled immunoglobulin derived from animals immunized to the chlamydial agent of guinea pig inclusion conjunctivitis. genital infections in animals receiving pooled immunoglobulin from immune animals were markedly decreased with regard to the number of inclusions detected compared with control animals. these data indicated that serum-derived antibody was able to provide a degree of protection against a chlamydial genital tract infection.	1989	2909492
[prevention of stress ulcer and nosocomial pneumonia].		2010	2905096
benign familial haematuria.		2010	2900928
lipid solubility of a series of drugs and its relevance to fatal poisoning.	for 11 commonly used drugs, the n-octanol/water partition coefficient (ph 7.4 temperature 37 degrees c) and solubility in n-octanol were determined. the drugs tested were chlorpromazine, amitriptyline, trazodone, dextropropoxyphene, diltiazem, dibucaine, amethocaine, procaine, quinidine, acetylsalicylic acid and paracetamol. for eight of the drugs, the relative lipid saturation corresponding to a fatal plasma concentration was estimated from the two parameters determined above and the median fat ...	2010	2897446
effect of salt depletion on sodium concentration in serum and urine of bufo chilensis. evidences for increased levels of neurohypophysial principles in their plasma.	salt-depleted toads bufo chilensis were compared with animals maintained in nacl solution and a control group with respect to na+ content in serum and urine. plasma hydro-osmotic activity of the animals was measured by increased water transfer across the isolated urinary bladder of the frog (caudiverbera caudiverbera). sodium in serum is not affected by pre-adaptation in distilled water. urine na+ is markedly reduced. plasma from depleted animals increases water transfer across the isolated urin ...	2010	2881665
treatment of silent myocardial ischemia with transdermal nitroglycerin added to beta-blockers and alprazolam.	investigations into the mechanisms and characteristics of ischemic heart disease have increasingly documented evidence of myocardial ischemia in the absence of symptoms. recent work using objective criteria of ischemic episodes confirmed that angina pectoris or its equivalents need not accompany myocardial ischemia and noted that these episodes appear to be quite common. the impact on prognosis awaits further study, but preliminary data suggest an adverse prognosis for patients with recurrent sp ...	2010	2877735
adrenergic and cholinergic stimulation of arachidonate and phosphatidate metabolism in cultured astroglial cells.	primary cultures of neonatal rat brain polygonal astroglia, or cells of the c62b glioma line, were incubated with [1-14c]arachidonic acid (aa) in culture for 18 hr. in both culture systems, more than 80% of the added [1-14c]aa was taken up into cellular glycerolipids; less than 1% of the radioactivity in the cells was present in an unesterified form. when prelabeled c62b cells were stimulated with acetylcholine (ach), there was a rapid accumulation of arachidonyl-phosphatidic acid (pa) accompani ...	1986	2875401
[drug damage of the liver].		2010	2873488
bevantolol hydrochloride--preclinical pharmacologic profile.	bevantolol hydrochloride, a beta adrenoceptor antagonist, can be categorized using conventional schemes as being cardioselective, devoid of intrinsic sympathomimetic activity and having weak membrane-stabilizing and local anesthetic properties. the cardioselectivity of bevantolol was conferred by the incorporation of a 3,4-dimethoxyphenyl moiety into the terminal amino portion of the molecule. this portion of the molecule also appears to account for bevantolol's in vitro binding affinity at alph ...	1986	2871786
relationship between hepatitis b surface antigen prevalence, per capita alcohol consumption and primary liver cancer death rate in 30 countries.	the relationships between the prevalence of hepatitis b surface antigen (hbsag), mean annual per capita alcohol consumption and primary liver cancer (plc) death rates were explored in 30 countries. hbsag prevalence was associated, significantly, with the logarithm of the primary liver cancer death rate (simple correlation coefficient = 0.44, p less than 0.05). this significant association increased following adjustment for a country's mean annual per capita alcohol consumption (partial correlati ...	2010	2843610
baroreceptor-independent medullary mechanism for release of vasopressin during hypotension in rats.	plasma vasopressin (avp) levels were measured at rest (mean arterial pressure 80-85 mmhg) and during hypotension (mean arterial pressure 38-45 mmhg) induced by ganglionic blockade (trimethaphan) in halothane-anaesthetized respirated rats with end-tidal pco2 maintained at 34-40 mmhg. hypotension (15 min) produced a 310% increase in plasma avp (+/- 60% s.e.m.) which was not reduced significantly by prior baro- and chemoreceptor denervation. the hypotension-induced rise in avp was blocked by bilate ...	1988	2842427
mineral retention in young men consuming soy-fiber-augmented liquid-formula diets.	the effect of a nutritionally complete liquid-formula diet without soy polysaccharide or with the fiber source at 20, 30, or 40 g/d on mineral retention in young men was examined. addition of 20 g soy polysaccharide to the liquid formula significantly (p less than 0.05) improved the retentions of copper, iron, zinc, and magnesium over the diet without added fiber. the highest level of soy polysaccharide (40 g/d) resulted in significantly (p less than 0.05) lower cu, zn, fe, and mg retentions tha ...	2010	2841841
noradrenergic projections to brainstem nuclei: evidence for differential projections from noradrenergic subgroups.	retrograde transport of the fluorescent tracer true blue was used in combination with immunohistochemical staining of dopamine-beta-hydroxylase (a marker protein for noradrenergic neurons) to determine the origin of noradrenergic projections to three cranial nerve nuclei: 1) the motor nucleus of the trigeminal nerve, 2) the motor nucleus of the facial nerve, and 3) the spinal trigeminal nucleus pars interpolaris. noradrenergic cells in the rat brainstem were divided into subgroups and their numb ...	1987	2822772
[encapsulating peritonitis in periodic disease. apropos of a case studied by x-ray computed tomography].	a case of encapsulating peritonitis complicating the course of familial mediterranean fever is reported. this encapsulating peritonitis was responsible for abdominal pain and had a "pseudocystic" appearance on ultrasonography and computed tomography. ultrasound guided aspiration produced a yellowish fluid rich in proteins and poor in cells. surgical operation revealed a congested appearance of the peritoneum associated with a richly fibrinous appearance of the external wall of the mass. the diff ...	2010	2817728
abnormalities of mitochondrial enzymes in hereditary ataxias.	the activity of 7 mitochondrial enzymes, fumarase, nad-malate dehydrogenase (mdh), citrate synthase (cs), valine dehydrogenase (vdh), succinate dehydrogenase (sdh), glutamate dehydrogenase (gdh), pyruvate dehydrogenase complex (pdhc) has been measured in platelet preparations from patients affected by friedreich's ataxia (fa), dominant and non-dominant olivopontocerebellar atrophy (dopca, ndopca) and normal individuals. significant decreases of gdh (p less than 0.01), pdhc (p less than 0.01), vd ...	2010	2816270
[use of the kimray-greenfield filter in the prevention of pulmonary embolism. personal experience].	personal experience in the use of intra-caval filters in the prevention of pulmonary embolisms is reported. the advantages and the indications for positioning of the k.g. filter are analysed on the basis of a series of 31 patients operated on with this method.	2009	2812457
[use of the kimray-greenfield filter in the prevention of pulmonary embolism. personal experience].	personal experience in the use of intra-caval filters in the prevention of pulmonary embolisms is reported. the advantages and the indications for positioning of the k.g. filter are analysed on the basis of a series of 31 patients operated on with this method.	2009	2812457
clinicopathologic spectrum of cutaneous manifestations in systemic follicular lymphoma. a study of 11 patients.	follicular lymphoma is rarely diagnosed on the basis of only a cutaneous biopsy. eleven patients with primary follicular lymphoma of lymph nodes who developed skin lesions were studied. skin lesions involved the scalp, head and neck, trunk, and buttocks and were small cleaved cell type in four cases, large cell type in three cases, and mixed type in four cases. the follicular pattern with a bottom-heavy distribution was identified in only six of the 11 cases. one case showed a nodular, perivascu ...	2009	2789095
[verapamil in primary hyperparathyroidism].	in a female patient with primary hyperparathyroidism and disturbances of cardiovascular function clinical, biochemical and electrocardiographic as well as bone scintigraphic parameters were analyzed before and during therapy with verapamil (falicard) for 7 month. verapamil therapy resulted in decrease of the frequency of the supraventricular tachycardia, and, in higher doses (4 x 120 mg), also reduction of blood pressure, however, with dose limiting bradycardia and prolongation of pq-time. both ...	2009	2763597
bioavailability of hydroxychloroquine tablets in healthy volunteers.	1. five healthy volunteers received, in a randomised crossover design study, a 155 mg oral tablet and an intravenous infusion of 155 mg racemic hydroxychloroquine (200 mg hydroxychloroquine sulphate) to assess the bioavailability of the commercially available tablet (plaquenil, winthrop laboratories, australia). 2. the terminal elimination half-life of hydroxychloroquine is more than 40 days, thus blood and urine samples were collected for 5 months following each dose to characterise adequately ...	2009	2757893
[the rehabilitation phase of hand surgery].		2009	2748164
clinical significance of the immunological tests in rheumatoid arthritis.	of the many theoretical causes of rheumatoid arthritis(ra), the most widely held theory is the autoimmune mechanism. in order to clarify the clinical significance of the immunological tests in ra, we studied immunoglobulin and complement levels in sera and synovial fluids of 118 ra patients and the following results were obtained. 1) the levels of immunoglobulins were elevated in both serum and synovial fluid and this was more prominent in the seropositive cases than the seronegative ones. 2) th ...	2009	2741472
quality assurance: public hospital clinics.		2009	2738944
use of the glucose oxidase/peroxidase method for glucose assay leads to overestimation of the inhibition of gluconeogenesis by aminopyrine.	4-aminoantipyrine strongly inhibits glucose determination by the glucose oxidase/peroxidase/dianisidine assay but does not interfere in the assay using glucose-6-phosphate dehydrogenase, hexokinase and atp. as a result, the inhibition of gluconeogenesis by aminopyrine reported to be 50-90% (bánhegyi, g., mandl, j., antoni, f. and garzó, t. (1987) biochim. biophys. acta 927, 406-416) is strongly overestimated and amounts to only 10-30%.	1989	2713417
myofascial pain dysfunction and viola playing.	two cases are illustrated to demonstrate the importance of occupation, in the form of viola playing, in the aetiology of myofascial pain dysfunction. an understanding of the contribution of tension and playing style, together with physical limitations, is emphasised and, consequently, it is acknowledged that modification may be necessary to the formulation of a treatment plan.	2009	2713183
[immunopathology of glomerulonephritis with mesangial iga deposits].	iga nephropathy is the most frequent type of glomerulonephritis in france. its definition is on renal pathology. mesangial iga deposits are dimeric or polymeric and probably from secretory origin. circulating iga molecules correspond to immune complexes with unknown antigens. the iga subclass remains still controversial: exclusive iga1 versus iga1 and iga2. the pathogenesis of the disease is based on an immune defect specific of the secretory iga system and eventually of the serum iga system. th ...	1989	2699007
when to use posts.		2009	2698331
falciparum malaria--present day problems. an experience with 425 cases.	clinical details and present day problems encountered in 425 cases of falciparum malaria (pf) are reported. 10.11% had taken chloroquine prior to reporting to us. parasitic count done in 23.05% cases lacked correlation with severity of disease. pattern of fever varied markedly but 5.4% were afebrile throughout and presented only with bodyache and malaise. apyrexial spell was noted in 5.64%. 28.70% had typical facial looks of anaemia and sallow complexion. cerebral symptoms were noted in 3.05%. o ...	1989	2693436
minitek urea disk test, a sensitive and cost-effective method to screen for campylobacter pylori in gastric biopsies.	one hundred fifty-five biopsy specimens from the gastric mucosa of 81 patients undergoing routine endoscopy procedures were tested for the presence of campylobacter pylori by three methods: gram stain, culture, and modified minitek, a rapid urea disk test (bbl microbiology systems, cockeysville, md.). twenty-nine patients were infected with c. pylori. sensitivities and specificities of detection were 100 and 94% with the minitek test and 93 and 100% with gram stain, respectively. rapid testing b ...	1989	2687317
differing responses in right and left ventricular filling, loading and volumes during positive end-expiratory pressure.	using a combined hemodynamic and radionuclide technique, 20 patients with varied ventricular function were evaluated during positive end-expiratory pressure (peep) application. left ventricular (lv) and right ventricular (rv) ejection fractions and cardiac output were measured, and ventricular volumes were derived. seven patients (group 1) who had an increase in lv end-diastolic volume with peep and 13 patients (group 2) who had the more typical response, a decrease in lv end-diastolic volume wi ...	2009	2679024
[the hormonal response in bulls to the administration of zeranol and rumensin].	the objective of the study was to investigate the influence of the growth stimulators ralgro zeranol and rumensin on changes in concentrations of certain hormones in the blood of beef bulls. in the first experiment 21 bulls were investigated which were divided into three groups. the first group was control, the second was administered the ralgro stimulator (3x) and the third the ralgro and rumensin stimulators. in the second experiment there were 12 bulls. the animals in the test group were impl ...	1989	2667252
dna alkylation and formation of dna interstrand cross-links by potential antitumour 2,5-bis(1-aziridinyl)-1,4-benzoquinones.	a series of 3,6-substituted 2,5-bis(1-aziridinyl)-1,4-benzoquinone derivatives was shown to alkylate calf thymus dna and to form dna interstrand cross-links. alkylation and cross-link formation were enhanced after electrochemical reduction of the compounds and increased with lower ph in the ph range from 4.5 to 8.0. reduction especially shifts the ph at which cross-linking and alkylation occurs to higher values, which are more physiologically relevant. this shift is probably caused by the increa ...	1989	2663197
duplex doppler evaluation of renal allograft dysfunction.		2009	2652615
assessing clamp-related vascular injuries by measurement of associated vascular dysfunction.	the development of vascular clamps requires a reliable method to quantitate clamp-related vascular injuries. the degree of vessel damage usually is estimated subjectively from photomicrographs made with scanning electron microscopy. in order to test whether the use of vascular rings to assess residual vascular function may be a better method, rabbit thoracic aortas were occluded by five types of clamps: a fogarty softjaw bulldog, a fogarty hydragrip, a 6-inch satinsky clamp, an edslab bulldog, a ...	1989	2648627
differential regulation of oncogenic and cellular p185 by serine/threonine kinases.	185c-neu is a member of a family of growth factor receptors with tyrosine kinase activity. a point mutation in the transmembrane region leads to activation of the enzymatic domain. we demonstrate that tpa (phorbol-12-myristate-13-acetate) stimulates the phosphorylation of p185c-neu on serine and threonine residues coincident with the inhibition of its intrinsic tyrosine kinase and the proliferation of cells that express it. the tyrosine kinase activity as well as the phosphorylation pattern of s ...	2008	2575488
acetylcholine causes nicotinic depolarization in rat dorsal motor nucleus of the vagus, in vitro.	action of acetylcholine (ach) on the electrophysiologically identified preganglionic neurons in the dorsal motor nucleus of the vagus (dmv) were investigated in slice preparations of rat medulla oblongata by using conventional intracellular recording technique. applications of ach to the dmv neurons resulted in a marked depolarization, which was not abolished in ca-free superfusing solution, indicating the direct action of ach on the cells. this depolarization was associated with an increase in ...	1989	2575433
glutamate-immunoreactivity in the retina and optic tectum of goldfish.	glutamate was immunohistochemically localized in the goldfish retina and tectum at the light and electron microscopic (e.m.) levels using double affinity purified antisera against glutaraldehyde conjugated l-glutamate. in retina, glutamate-immunoreactivity (glu+) was observed in cone inner segments, cone pedicles, bipolar cells, a small number of amacrine cells and the majority of cells in the ganglion cell layer. the latter were shown to be ganglion cells by simultaneous retrograde labeling. ce ...	2008	2575431
cardiac hypersensitivity to 5-aminosalicylic acid.		2008	2566070
[percutaneous drainage of fistula-associated abscesses and biliary fistulas].	33 abdominal abscesses associated with fistulae in 31 patients were treated by percutaneous drainage. 19 of these patients had had surgery immediately preceding the drainage. in 64% the percutaneous drainage led to a diagnosis of an internal fistula. additional therapeutic measures, because of the fistula, were necessary in 45% (operation, biliary drainage, repositioning of catheter). the average duration of drainage was 29 days. 77% of those abscesses which could be drained were treated success ...	2008	2538887
infective endocarditis in children. a seven-year experience.	eighteen children with infective endocarditis were detected over seven years. fever, gastrointestinal and chest symptoms were striking features. anaemia, elevated leukocyte count and sedimentation rate were constant laboratory findings. strep. viridans and staph. aureus were the commonest organisms isolated. we concluded that rheumatic and congenital heart disease are equally important in predisposition to infective endocarditis.	2008	2519331
[tissue-type plasminogen activator and pro-urokinase--new fibrinolytic agents in the treatment of myocardial infarction].	in the light of a survey of the pertinent literature the results of tissue plasminogen activator and pro-urokinase++ use in the thrombolytic treatment of acute myocardial infarction are discussed.	2008	2516932
sporidesmin and gliotoxin induce cell detachment and perturb microfilament structure in cultured liver cells.	changes in cell morphology and cell adhesion occurred when cultured cells from the rat liver cell strain c3 were exposed to the fungal toxins, sporidesmin or gliotoxin. both toxins caused loss of attachment of the cells to the plastic of tissue culture plates and this effect was preceded by loss of actin cables. other changes included cytoplasmic vacuolation and blocked entry into s-phase of the cell cycle. under these conditions [3h]thymidine incorporation into the cells was also diminished but ...	1986	2432076
mechanics of the lung and chest wall.		2008	2291386
aerosol application of interferon-alpha in the treatment of bronchioloalveolar carcinoma.	10 patients with locally advanced bronchioloalveolar carcinoma were treated with interferon-alpha as an inhaled aerosol. initial doses ranged between 1 and 10 mu daily or thrice weekly and were then increased to 20 mu daily. treatment was continued until disease progression or excessive toxicity occurred, 9 patients were evaluable for toxicity. in 1 case treatment had to be stopped after 2 weeks due to fever, fatigue and progressive dyspnoea. 2 patients developed fever, 1 had malaise, fatigue an ...	2007	2168195
[new antitubercular drugs].		1990	2168041
[prenatal ultrasonic diagnosis of developmental abnormalities of the organs of the digestive system].	analysis is made of the results of ultrasound diagnosis of developmental abnormalities of the alimentary tract. it has been established that the information content of echography is dependent on the anatomic intensity of an abnormality and the period of pregnancy at which the examination was done. it has been shown that the method is not of high diagnostic significance in revealing developmental abnormalities of the upper lip and hard palate, atresia of the esophagus, large intestine and rectum. ...	2007	2075063
experimental arterial thrombosis in nonhuman primates.	the baboon offers many advantages as an experimental animal to study vascular disease, thrombus formation and dissolution, effects of mediating variables, and the relative efficacy of therapeutic interventions. each specific application for testing therapeutic agents may require testing in somewhat different model systems. for example, although the arteriovenous vascular graft model is efficient, cost effective, and well adapted to study of interventions for acute arterial thrombosis, surgical e ...	2007	2040071
time to adoption of an innovation by dentists in private practice: sealant utilization.	dentists can be divided into five adoption categories based upon their time of adoption of pit and fissure sealants: innovators, early adopters, early majority, late majority, and laggards. the differences among dentists in the five adoption categories were examined for four classes of variables: practice characteristics, dentist characteristics, communication of information, and practice environment. questionnaires were mailed in september 1984 to a random sample (n = 521) of washington state d ...	2007	1920266
differentiation of growth signal requirement of b lymphocyte precursor is directed by expression of immunoglobulin.	during b cell differentiation, at least three stages can be defined in terms of their growth signal requirement by using two different growth signals, which are recombinant interleukin 7 (il-7) and a stromal cell clone pa6 which does not produce il-7; first a pa6 dependent stage, second a pa6 + il-7 dependent stage and third an il-7 dependent stage. in order to test the possibility that this differentiation of growth signal requirement is controlled by the expression of functional immunoglobulin ...	1991	1899373
[the modelling of the development of respiratory muscle force during forced expiration].		2006	1860565
[the modelling of the development of respiratory muscle force during forced expiration].		2006	1860565
inactivation of human immunodeficiency virus (hiv) by low ph and pepsin.		1991	1856798
inactivation of human immunodeficiency virus (hiv) by low ph and pepsin.		1991	1856798
sensationalism or sensitivity: use of words in stories on acquired immune deficiency syndrome (aids) by associated press videotext.	although it appeared initially reluctant to cover the story at all, the mainstream press in the united states has supplied almost daily reports on aids since the mid-1980s. the author examined four weeks of stories on the associated press videotext service in early 1986 in an effort to evaluate the validity of critics' charges that journalists were over-emphasizing the role of homosexuals in the progress of the disease, and that their stories were laden with negative or sensationalistic terms. t ...	2006	1856471
diffuse neonatal hemangiomatosis: a new constellation of findings.	diffuse neonatal hemangiomatosis is a rare, frequently fatal disease characterized by multiple cutaneous and visceral hemangiomas. the skin, liver, lungs, intestines, and central nervous system are the most commonly affected organs. death can result from high-output cardiac failure as a result of arteriovenous shunting. in this report we present a new constellation of findings in a patient with diffuse neonatal hemangiomatosis, namely, an absent corpus callosum, ectopia cordis (sternal agenesis) ...	2007	1828812
home course in electrocardiography. lesson 3. axis and axis deviation.		2007	1828662
[pressure sensors give a receit for balloon dilatation. do new sensors improve the pacemaker?].		2003	1774977
seasonal variation of peripheral thyroid hormone levels in major depression.	the seasonal variation in thyroid function tests was examined in 138 patients with major depression. no alterations in thyroxine, free thyroxine index, triiodothyronine, t3 resin uptake and thyrotropin were observed across the four seasons. this applied to both male and female subgroups. these data suggest that seasonality does not account for the wide variability in abnormalities of thyroid function reported in depression.	2005	1774423
thermogenic and hormonal responses to palatable protein and carbohydrate rich food.	simultaneous variations of oxygen consumption, and plasma insulin and norepinephrine were measured during the postprandial cephalic and gastrointestinal phases of feeding in six human subjects following the ingestion of various nutrients. on alternative days the subjects were given foods (1280 kjoules) either rich in carbohydrates (sugar pie) or in proteins (fish). both nutrients produced an initial (0-40 min) enhanced thermogenesis and an early (2 min) cephalic insulin release. during that peri ...	1991	1774019
uterus didelphys and pregnancy: an unusual case in an 18-year-old patient.	an unusual case of a full-term pregnancy in a patient with a uterus didelphys is presented. the main complication was the formation of pyocolpos in a blind hypoplastic hemivagina observed early in gestation. the therapeutic approach and the related problems are discussed.	2006	1563657
external cephalic version and daily post-versional maternal self-assessment of fetal presentation. a prospective study.	external cephalic version (ecv) using tocolysis is a widely recognized low-risk intervention in cases of breech presentation, particularly in areas where resources are scarce and the perinatal mortality is high in vaginal breech deliveries. in such a setting, pregnant women were trained to make regular self-assessments of the presenting fetal part after ecv in order to detect spontaneous reversions to breech presentation. it was found that such maternal involvement could significantly improve th ...	2006	1563651
2,6-dichlorophenolindophenol is a competitive inhibitor for xanthine oxidase and is therefore not usable as an electron acceptor in the fluorometric assay.	xanthine oxidase has been recognized as an important source of oxygen free radicals in ischemia-reperfusion injury. in order to study this enzyme in biological tissues, the conversion of pterin (2-amino-4-hydroxypteridine) to isoxanthopterin provides the basis for a very sensitive fluorometric assay. xanthine oxidase is typically assayed in the presence of pterin only, while an electron acceptor which replaces nad+ is used to determine the combined xanthine dehydrogenase plus xanthine oxidase ac ...	1992	1563644