Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| novel chlamydia trachomatis strains in heterosexual sex partners, indianapolis, indiana, usa. | chlamydia trachomatis causes a high number of sexually transmitted infections worldwide, but reproducible and precise strain typing to link partners is lacking. we evaluated multilocus sequence typing (mlst) for this purpose by detecting sequence types (sts) concordant for the ompa genotype, a single-locus typing standard. we tested samples collected during april 2000-october 2003 from members of established heterosexual partnerships (dyads) in the indianapolis, indiana, usa, area who self-repor ... | 2014 | 25340463 |
| conserved type iii secretion system exerts important roles in chlamydia trachomatis. | upon infection, chlamydiae alter host cellular functions in a variety of ways. chlamydial infection prevents host cell apoptosis, induces re-organization of the actin cytoskeleton and alters host cellular signaling mechanisms. chlamydia is among the many pathogenic gram-negative bacteria that employ the type iii secretion system (t3ss) to overcome host defenses and exploit available resources. t3ss are used by many gram-negative bacterial pathogens to manipulate eukaryotic host cells through the ... | 2014 | 25337183 |
| evidence for increased chlamydia case finding after the introduction of rectal screening among women attending 2 canadian sexually transmitted infection clinics. | chlamydia trachomatis is the most common notifiable disease in canada, and extragenital sites are believed to serve as hidden reservoirs for ongoing transmission of infection. there are no specific canadian screening guidelines for asymptomatic individuals from extragenital sites. we sought to determine the prevalence and factors associated with rectal c. trachomatis among female sexually transmitted infection (sti) clinic attendees in alberta, canada. | 2015 | 25336625 |
| a descriptive study of urethral discharge among men in fiji. | urethral discharge is a common presentation of sexually transmitted infection (sti) in men and known pathogens include neisseria gonorrhoeae and chlamydia trachomatis. there are no published data of the burden of urethral discharge among men in fiji. | 2014 | 25331311 |
| male infertility: a public health issue caused by sexually transmitted pathogens. | sexually transmitted diseases (stds) are caused by several pathogens, including bacteria, viruses and protozoa, and can induce male infertility through multiple pathophysiological mechanisms. additionally, horizontal transmission of std pathogens to sexual partners or vertical transmission to fetuses and neonates is possible. chlamydia trachomatis, ureaplasma spp., human papillomavirus, hepatitis b and hepatitis c viruses, hiv-1 and human cytomegalovirus have all been detected in semen from symp ... | 2014 | 25330794 |
| genital tract infection with chlamydia trachomatis in women attended at a cervical cancer screening program in northeastern from brazil. | this cross-sectional study aimed to estimate the prevalence of chlamydia trachomatis (ct) infection alone and in combination with human papillomavirus (hpv). furthermore, the study investigates whether the ct infection increases the risk of contracting hpv and whether the presence of both pathogens is associated with a higher prevalence of cervical lesions. | 2015 | 25326872 |
| an α-helical core encodes the dual functions of the chlamydial protein inca. | chlamydia is an intracellular bacterium that establishes residence within parasitophorous compartments (inclusions) inside host cells. chlamydial inclusions are uncoupled from the endolysosomal pathway and undergo fusion with cellular organelles and with each other. to do so, chlamydia expresses proteins on the surface of the inclusion using a type iii secretion system. these proteins, termed incs, are located at the interface between host and pathogen and carry out the functions necessary for c ... | 2014 | 25324548 |
| screening for gonorrhoea using samples collected through the english national chlamydia screening programme and risk of false positives: a national survey of local authorities. | to investigate use of dual tests for chlamydia trachomatis and neisseria gonorrhoeae on samples collected through the national chlamydia screening programme (ncsp) in england. | 2014 | 25324326 |
| prevalence of chlamydia trachomatis, neisseria gonorrhoeae and mycoplasma genitalium in asymptomatic patients under 30 years of age screened in a french sexually transmitted infections clinic. | an increasing prevalence of sexually transmitted infections (sti) has been noted in france over the past decade. asymptomatic carriage may be high in patients infected with chlamydia trachomatis attending free and anonymous screening centres (cdag) and information, diagnosis and screening centres for sti (ciddist). in these centres, systematic c. trachomatis detection is recommended in women ≤25 years and in men ≤30 years. | 2014 | 25322708 |
| there has been a true rise in neisseria gonorrhoeae but not in chlamydia trachomatis in men who have sex with men in dublin, ireland. | 2014 | 25316918 | |
| chlamydia trachomatis remodels stable microtubules to coordinate golgi stack recruitment to the chlamydial inclusion surface. | chlamydia trachomatis (ctr), an obligate intracellular bacterium, survives and replicates within a membrane-bound vacuole, termed the inclusion, which intercepts host exocytic pathways to acquire nutrients. ctr subverts cellular trafficking pathways from the golgi by targeting small gtpases, including rab proteins, to sustain intracellular bacterial replication; however, the precise mechanisms involved remain incompletely understood. here, we show that chlamydia infection in human epithelial cel ... | 2014 | 25315131 |
| antibiotic use before chlamydia and gonorrhea genital and extragenital screening in the sexually transmitted infection clinical setting. | background antibiotic use (i.e., administration of antibiotics not directly related to chlamydia trachomatis or neisseria gonorrhoeae infections) has been associated with a lower prevalence of genital c. trachomatis infection in a clinical setting. associations with specific antibiotic types or with n. gonorrhoeae are lacking. here, we assessed the prevalence of antibiotic use, the different classes and agents used, and their association with a subsequent sexually transmitted infection (sti) cli ... | 2014 | 25313220 |
| prevalence and risk factors for chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis infection in pregnant women in papua new guinea. | to determine the prevalence of, and risk factors associated with, chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis infection in pregnant women in madang, papua new guinea (png). | 2015 | 25313204 |
| the eukaryotic signal sequence, ygrl, targets the chlamydial inclusion. | understanding how host proteins are targeted to pathogen-specified organelles, like the chlamydial inclusion, is fundamentally important to understanding the biogenesis of these unique subcellular compartments and how they maintain autonomy within the cell. syntaxin 6, which localizes to the chlamydial inclusion, contains an ygrl signal sequence. the ygrl functions to return syntaxin 6 to the trans-golgi from the plasma membrane, and deletion of the ygrl signal sequence from syntaxin 6 also prev ... | 2014 | 25309881 |
| paper-based molecular diagnostic for chlamydia trachomatis. | herein we show the development of a minimally instrumented paper-based molecular diagnostic for point of care detection of sexually transmitted infections caused by chlamydia trachomatis. this new diagnostic platform incorporates cell lysis, isothermal nucleic acid amplification, and lateral flow visual detection using only a pressure source and heat block, eliminating the need for expensive laboratory equipment. this paper-based test can be performed in less than one hour and has a clinically r ... | 2014 | 25309740 |
| [performance of a standardized interrogation to improve the screening of chlamydia trachomatis infection]. | to estimate the performance of a standardized interrogation tool facilitating the detection and screening of patients for the chlamydia trachomatis infection, to estimate the prevalence of the infection in the family planning population studied. | 2015 | 25307616 |
| feasibility and acceptance of cervicovaginal self-sampling within the german national cohort (pretest 2). | within the german national cohort (gnc) 100,000 adult women in germany will be comprehensively interviewed and examined. while women's health is addressed in the basic interview, direct detection of cervicovaginal microbial colonisation or infection is not part of the examination protocol. in a pilot project the feasibility of female study participants of the gnc collecting a cervicovaginal lavage at home without having to involve a gynecologist or other medical personnel was thus investigated. ... | 2014 | 25303829 |
| predictors of index patient acceptance of expedited partner therapy for chlamydia trachomatis infection and reasons for refusal, sexually transmitted disease clinics, new york city, 2011 to 2012. | expedited partner therapy (ept) for chlamydia trachomatis (ct) reduces repeat ct infection and was legalized in new york state in 2009. it is a practice in which a ct-infected index patient delivers medication or a prescription directly to sex partner(s), without those partners receiving medical evaluation. there have been few evaluations of ept implementation assessing acceptance and uptake among index patients. we measured ept acceptance among index patients, identified predictors of accepting ... | 2014 | 25299418 |
| diagnostic efficacy of a real time-pcr assay for chlamydia trachomatis infection in infertile women in north india. | little is known about the prevalence of chlamydia trachomatis infection in indian women with infertility. to improve the diagnosis of c. trachomatis infection in developing countries, there is an urgent need to establish cost-effective molecular test with high sensitivity and specificity. this study was conducted to determine the diagnostic utility of a real time-pcr assay for detention of c. trachomatis infection in infertile women attending an infertility clinic in north india. the in house re ... | 2014 | 25297359 |
| septins arrange f-actin-containing fibers on the chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion. | chlamydia trachomatis is an obligate intracellular human pathogen that grows inside a membranous, cytosolic vacuole termed an inclusion. septins are a group of 13 gtp-binding proteins that assemble into oligomeric complexes and that can form higher-order filaments. we report here that the septins sept2, -9, -11, and probably -7 form fibrillar structures around the chlamydial inclusion. colocalization studies suggest that these septins combine with f actin into fibers that encase the inclusion. t ... | 2014 | 25293760 |
| in vitro activity of azd0914, a novel dna gyrase inhibitor, against chlamydia trachomatis and chlamydia pneumoniae. | the in vitro activities of azd0914, levofloxacin, azithromycin, and doxycycline against 10 isolates each of chlamydia trachomatis and chlamydia pneumoniae were tested. for azd0914, the mic90s for c. trachomatis and c. pneumoniae were 0.25 μg/ml (range, 0.06 to 0.5 μg/ml) and 1 μg/ml (range, 0.25 to 1 μg/ml), respectively, and the minimal bactericidal concentrations at which 90% of the isolates were killed (mbc90s) were 0.5 μg/ml for c. trachomatis (range, 0.125 to 1 μg/ml) and 2 μg/ml for c. pne ... | 2014 | 25288086 |
| a simple procedure to analyze positions of interest in infectious cell cultures by correlative light and electron microscopy. | plastic cell culture dishes that contain a thin bottom of highest optical quality including an imprinted finder grid (μ-dish grid-500) are optimally suited for routine correlative light and electron microscopy using chemical fixation. such dishes allow high-resolution fluorescence and bright-field imaging using fixed and living cells and are compatible with standard protocols for scanning and transmission electron microscopy. ease of use during cell culture and imaging, as well as a tight cover ... | 2014 | 25287838 |
| crystallization and preliminary x-ray diffraction studies of the c-terminal domain of chlamydia trachomatis cdsd. | the inner membrane ring of the bacterial type iii secretion system (ttss) is composed of two proteins. in chlamydia trachomatis this ring is formed by cdsd (gene name ct_664) and cdsj (gene name cta_0609). cdsd consists of 829 amino acids. the last 400 amino acids at its c-terminal end relate it to the type iii secretion system yscd/hrpq protein family. the c-terminal domain, consisting of amino acids 558-771, of c. trachomatis cdsd was overexpressed in escherichia coli and purified using immobi ... | 2014 | 25286957 |
| sexual history taking in the emergency department - more specificity required. | chlamydia trachomatis (ct) and neisseria gonorrhoeae (gc) are the most reported diseases in the united states, and emergency departments (ed) serve a population presenting with increased infection risk. however, identifying patients for whom sexually transmitted infection (sti) screening is appropriate requires accurate sexual history reporting. | 2015 | 25282115 |
| cervical ectopy: associations with sexually transmitted infections and hiv. a cross-sectional study of high school students in rural south africa. | it has been hypothesised that ectopy may be associated with increased susceptibility to sexually transmitted infections (stis). in this cross-sectional study, we wanted to explore the association between stis (including hiv) and cervical ectopy. | 2014 | 25281761 |
| prevalence of trichomonas vaginalis, chlamydia trachomatis, neisseria gonorrhoeae and human papillomavirus in a sexual health clinic setting in urban sri lanka. | the prevalences of trichomonas vaginalis, chlamydia trachomatis, neisseria gonorrhoeae, and human papillomavirus (hpv) in sri lanka are not well reported; the objective of this study is to describe the prevalences of these four sexually transmitted infections among attendees of sexual health clinic in an urban setting. vaginal swabs were collected from consenting women attending a sexual health clinic and tested for the presence of the above sexually transmitted infections using nucleic acid amp ... | 2015 | 25258396 |
| chlamydia trachomatis infection is related to premature ejaculation in chronic prostatitis patients: results from a cross-sectional study. | chronic bacterial prostatitis (cbp) is reported to be a common finding in men with acquired premature ejaculation (pe). the impact of different pathogens on pe development in chronic prostatitis patients is, however, unknown. | 2014 | 25256084 |
| prevalence of chlamydia trachomatis genital infection among persons aged 14-39 years--united states, 2007-2012. | infection with the bacterium, chlamydia trachomatis (often termed "chlamydia") is the most frequently reported sexually transmitted infection in the united states. the urethra is the most common site of infection in males, and the urethra and cervix are most commonly infected in females. ascending infection in females can cause pelvic inflammatory disease, which can lead to infertility and ectopic pregnancy. genital chlamydial infections are usually asymptomatic, and screening is necessary to id ... | 2014 | 25254560 |
| screening for chlamydia trachomatis and mycoplasma genitalium; is first void urine or genital swab best? | 2015 | 25253762 | |
| structural and biochemical characterization of chlamydia trachomatis hypothetical protein ct263 supports that menaquinone synthesis occurs through the futalosine pathway. | the obligate intracellular human pathogen chlamydia trachomatis is the etiological agent of blinding trachoma and sexually transmitted disease. genomic sequencing of chlamydia indicated this medically important bacterium was not exclusively dependent on the host cell for energy. in order for the electron transport chain to function, electron shuttling between membrane-embedded complexes requires lipid-soluble quinones (e.g. menaquionone or ubiquinone). the sources or biosynthetic pathways requir ... | 2014 | 25253688 |
| high prevalence and incidence of sexually transmitted infections among women living in kwazulu-natal, south africa. | sexually transmitted infections (stis) contribute largely to the burden of health in south africa and are recognized as major contributors to the human immunodeficiency virus (hiv) epidemic. young women are particularly vulnerable to stis. the purpose of this secondary analysis was to examine the risk factors associated with prevalent and incident stis among women who had participated in three clinical trials. | 2014 | 25243015 |
| social-, age- and gender differences in testing and positive rates for chlamydia trachomatis urogenital infection - a register-based study. | chlamydia trachomatis is suspected of causing female infertility. it is the most widespread sexually transmitted infection with an estimated general prevalence of ~5-10% with a peak in younger individuals. c. trachomatis infection is more prevalent among lower social classes. | 2014 | 25240514 |
| sexually transmitted infections in hiv-infected people in switzerland: cross-sectional study. | sexually transmitted infections (sti) in hiv-infected people are of increasing concern. we estimated sti prevalence and sexual healthcare seeking behaviour in 224 sexually active hiv-infected people, including men who have sex with men (msm, n = 112), heterosexual men (n = 65) and women (n = 47). laboratory-diagnosed bacterial sti were more common in msm (chlamydia trachomatis 10.7%; 95% ci 6.2, 18.0%, lymphogranuloma venereum 0.9%; 95% ci 0.1, 6.2%, neisseria gonorrhoeae 2.7%; 95% ci 0.9, 8.0%, ... | 2014 | 25237598 |
| spontaneous pharyngeal chlamydia trachomatis rna clearance. a cross-sectional study followed by a cohort study of untreated sti clinic patients in amsterdam, the netherlands. | pharyngeal chlamydia trachomatis (chlamydia) might contribute to ongoing chlamydia transmission, yet data on spontaneous clearance duration are rare. we examined the prevalence, spontaneous clearance, chlamydial dna concentration and genotypes of pharyngeal chlamydia among clinic patients with sexually transmitted infection (sti). | 2015 | 25237127 |
| epidemiology of sexually transmitted infections in rural haitian men. | the study attempts to determine the prevalence of organisms associated with urethritis in men in rural southwestern haiti and to determine the association with demographic, clinical and laboratory variables. a standardised verbal interview was conducted; genital examinations were done; urethral swabs were collected for nucleic acid amplification testing, and first void urine was obtained for urinalysis. the mean participant age was 54; 88.8% lived in a rural area. swabs were positive for trichom ... | 2015 | 25228665 |
| testing for sexually transmitted infections at intrauterine device insertion: an evidence-based approach. | this article reviews evidence to guide safe and cost-effective testing for asymptomatic neisseria gonorrhea and chlamydia trachomatis infection before inserting intrauterine devices (iuds). all women should be screened with a history and pelvic examination before iud insertion, but only high-risk women need a laboratory test; this includes women aged 25 years or younger with no test within the last year, and women with additional behavioral risk factors. if testing is indicated, it should be don ... | 2014 | 25222531 |
| lactobacilli inactivate chlamydia trachomatis through lactic acid but not h2o2. | lactobacillus species dominate the microbiome in the lower genital tract of most reproductive-age women. producing lactic acid and h2o2, lactobacilli are believed to play an important role in prevention of colonization by and growth of pathogens. however, to date, there have been no reported studies characterizing how lactobacilli interact with chlamydia trachomatis, a leading sexually transmitted bacterium. in this report, we demonstrate inactivation of c. trachomatis infectivity by culture med ... | 2014 | 25215504 |
| partner meeting place is significantly associated with gonorrhea and chlamydia in adolescents participating in a large high school sexually transmitted disease screening program. | from 2003 to 2012, the philadelphia high school std screening program screened 126,053 students, identifying 8089 chlamydia trachomatis (ct)/neisseria gonorrhoeae (gc) infections. we examined sociodemographic and behavioral factors associated with ct/gc diagnoses among a sample of this high-risk population. | 2014 | 25211256 |
| azithromycin efficacy in the treatment of chlamydia trachomatis among detained youth. | we assessed the efficacy of azithromycin among detained adolescents with chlamydia trachomatis. infected adolescents took azithromycin and submitted a test of cure. of the 128 youth, 5 patients experienced treatment failure. we found that azithromycin was 96.1% (95% confidence interval, 91.1%-98.8%) effective in treating chlamydia infections, supporting its continued use. | 2014 | 25211253 |
| impact of public housing relocations: are changes in neighborhood conditions related to stis among relocaters? | cross-sectional and ecologic studies suggest that place characteristics influence sexual behaviors and sexually transmitted infections (stis). using data from a predominately substance-misusing cohort of african american adults relocating from us public housing complexes, this multilevel longitudinal study tested the hypothesis that participants who experienced greater postrelocation improvements in neighborhood conditions (i.e., socioeconomic disadvantage, social disorder, sti prevalence, and m ... | 2014 | 25211249 |
| presence of aerobic micro-organisms and their influence on basic semen parameters in infertile men. | urogenital tract infections in males are one of the significant etiological factors in infertility. in this prospective study, 72 patients with abnormal semen parameters or any other symptoms of urogenital tract infection were examined. semen analysis according to the who 2010 manual was performed together with microbial assessment: aerobic bacteria culture, chlamydia antigen test, candida culture, ureaplasma and mycoplasma-specific culture. in total, 69.4% of semen samples were positive for at ... | 2015 | 25209133 |
| the performance and clinical utility of cervical microscopy for the diagnosis of gonorrhoea in women in the era of the naat. | we evaluated the performance and clinical utility of cervical microscopy for diagnosing genital gonorrhoea (gc) in women, using the aptima combo 2 dual gc/chlamydia trachomatis assay as the gold standard. test performance was assessed overall and for patient subgroups (symptomatic, gc contacts, pelvic inflammatory disease [pid] diagnosis). it was found that 93 women had positive gc genital naat results; 15 had positive cervical microscopy (8 were gc contacts). in all subgroups except gc contacts ... | 2015 | 25208533 |
| epidemiology of sexually transmitted infections in rural southwestern haiti: the grand'anse women's health study. | the study attempts to define socioeconomic, clinical, and laboratory correlates in vaginitis and other sexually transmitted infections in rural southwestern haiti. a convenience sample of subjects recruited from a rural women's health clinic and attending an established clinic at the haitian health foundation (hhf) clinic was studied. a standardized history and physical examination, including speculum examination, and collection of blood, urine, and vaginal swabs were obtained from the women at ... | 2014 | 25200263 |
| [pathogens in expressed prostatic secretion and their correlation with serum prostate specific antigen: analysis of 320 cases]. | to investigate the pathogenic infection and its drug resistance in expressed prostatic secretion (eps) and its correlation with serum psa, and provide some evidence for the systematic and normalized diagnosis and treatment of prostatitis. | 2014 | 25195368 |
| application of htb-siha cells transfected with a recombinant plasmid for external quality assessment of chlamydia trachomatis pcr. | the participation of laboratories in external quality assessment (eqa) programs is required for the quality assurance of nucleic acid amplification of chlamydia trachomatis. this study aimed to construct a new quality control (qc) material applicated in eqa of c. trachomatis pcr. | 2014 | 25187888 |
| [chlamydia trachomatis and neisseria gonorrhoeae infection: factors associated with infertility in women treated at a human reproduction public service]. | to evaluate the prevalence of chlamydia trachomatis and neisseria gonorrhoeae in women undergoing assisted reproduction in a public reference service in the midwestern region of brazil. | 2014 | 25184348 |
| lymphogranuloma venereum in an italian msm: concurrent pharyngeal and rectal infection. | an italian hiv-positive man having sex with men (msm) attended the stis outpatients clinic of sant'orsola hospital in bologna complaining of anal pain and constipation. according to patient's sexual history and repertoires, naat testing for chlamydia trachomatis (ct) and neisseria gonorrhoeae (gc) was performed. pharyngeal and anal swabs resulted positive for ct dna detection and the following molecular genotyping identified a l2 serovar, coming to the final diagnosis of pharyngeal and rectal ly ... | 2014 | 25180857 |
| comparative evaluation of roche aurora flow, becton and dickinson viper system, and dynex ds2 for detection of chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis in various clinical specimens. | the purpose of this study is to introduce a high-throughput system, aurora flow, for the simultaneous detection of 3 clinically relevant pathogens of sexually transmitted infections. comparative evaluation with other systems revealed an overall concordance of 97.9% for chlamydia trachomatis and comparable performance for neisseria gonorrhoeae and trichomonas vaginalis. | 2014 | 25172824 |
| a chemical mutagenesis approach to identify virulence determinants in the obligate intracellular pathogen chlamydia trachomatis. | our understanding of how most microbes "work" is hindered by the lack of molecular genetic and recombinant dna tools to manipulate their genomes. we devised an approach to perform genetic analysis in one such microbe, the obligate intracellular bacterial pathogen chlamydia trachomatis. comprehensive libraries of clone-purified mutants with distinct plaque morphologies were generated through chemical mutagenesis. whole-genome sequencing (wgs) was then employed to identify the underlying genetic l ... | 2014 | 25172291 |
| chlamydia trachomatis promotes 3t3 cell differentiation into adipocytes. | there is experimental and clinical evidence showing that some viral and bacterial pathogens are linked to the accumulation of excessive body fat and obesity. | 2014 | 25166434 |
| chlamydial infection, plasma peroxidation and obesity in tubal infertility. | genital tract infections and obesity are both sources of oxidative stress. alterations in immune and antioxidant parameters may arise from this or from an indeterminate autoimmune mechanism. | 2011 | 25161489 |
| [gonococcal and chlamydial infections of the urethra: new german guidelines]. | the german sti guidelines for gonococcal and chlamydial infections were recently updated. representing the german society of urology (dgu) in these guidelines consensus processes, the authors summarize the recommendations regarding screening, appropriate laboratory diagnostics and dose-increased dual antimicrobial therapy of urethritis caused by neisseria gonorrhoeae and chlamydia trachomatis. urologists need to be informed about an approaching era of untreatable gonorrhea. although of limited u ... | 2014 | 25159333 |
| no indication for tissue tropism in urogenital and anorectal chlamydia trachomatis infections using high-resolution multilocus sequence typing. | previous studies showed that c. trachomatis strains found in msm are different from those in heterosexuals. this study investigates whether the differences in strain distribution between msm and heterosexuals are due to tissue tropism. | 2014 | 25158743 |
| unusually low prevalence of mycoplasma genitalium in urine samples from infertile men and healthy controls: a prevalence study. | to detect mycoplasma genitalium in urine samples of infertile men and men without any signs of infection in order to investigate whether m. genitalium and other genital mycoplasmas (mycoplasma hominis and ureaplasma spp) are found more often in urine samples of infertile men than in asymptomatic controls and to determine resistance to macrolides. | 2014 | 25157184 |
| usefulness of quantifying leukocytes in first-voided urine to predict positivity for chlamydia trachomatis in asymptomatic men at high risk for chlamydial infection. | chlamydia trachomatis causes acute non-gonococcal urethritis, but some infected men are asymptomatic. we examined leukocytes in uncentrifuged first-voided urine (fvu) from asymptomatic men at high risk for chlamydial infection by automated urine particle analyzers to assess whether the quantification of urinary leukocytes could predict chlamydial infection in these men. we enrolled 209 asymptomatic men, whose female sexual partners had been diagnosed as having a genital chlamydial infection. the ... | 2014 | 25156010 |
| adolescent women with sexually transmitted infections: who gets lost to follow-up? | adolescent patients comprise the highest rate of neisseria gonorrhoeae (gc) and chlamydia trachomatis (ct) in the united states. these patients often initially present to the emergency department (ed) with vague symptoms. | 2014 | 25154560 |
| prevalence of chlamydia in young adulthood and association with life course socioeconomic position: birth cohort study. | few estimates are available of chlamydia prevalence in the general population. existing studies have limited scope to explore potential selection bias or associations with socioeconomic position. | 2014 | 25153124 |
| reiter's syndrome--disease of young men-- analysis of 312 patients. | reiter's syndrome is reactive arthritis occurring after acute urogenital (urethritis, cervicitis) or enterocolitis infections. the associated ophthalmological and/or mucocutaneous changes are full clinical manifestations of this disease. this paper was aimed at analyzing clinical and radiological characteristics and findings of possible etiological factors and protocol for reiter's syndrome therapy. | 2016 | 25151762 |
| risk factors for ectopic pregnancy in women with planned pregnancy: a case-control study. | to explore the risk factors for ectopic pregnancy (ep) in women with planned pregnancy. | 2014 | 25150957 |
| tuberculosis and the risk of infection with other intracellular bacteria: a population-based study. | summary persons who develop tuberculosis (tb) may have subtle immune defects that could predispose to other intracellular bacterial infections (icbis). we obtained data on tb and five icbis (chlamydia trachomatis, salmonella spp., shigella spp., yersinia spp., listeria monocytogenes) reported to the tennessee department of health, usa, 2000-2011. incidence rate ratios (irrs) comparing icbis in persons who developed tb and icbis in the tennessee population, adjusted for age, sex, race and ethnici ... | 2015 | 25148655 |
| comparison of genital chlamydia trachomatis infection incidence between women with infertility and healthy women in iran using pcr and immunofluorescence methods. | for a long time, infertility has been one of the most sequels in medical sciences with microbial agents as one group of its causes. the possible etiological role of chlamydia trachomatis in infertility was suggested years ago, but it has not yet been proved completely. to decrease the severe involvements of c. trachomatis infections, screening by efficient diagnostic methods are necessary. | 2014 | 25147704 |
| hpv and chlamydia trachomatis co-detection in young asymptomatic women from high incidence area for cervical cancer. | chlamydia trachomatis causing chronic inflammatory diseases has investigated as possible human papillomavirus (hpv) cofactor in cervical cancer. the aim of this study is to evaluate the prevalence of chlamydia trachomatis and hpv co-infection in different cohorts of asymptomatic women from a northern italy area at high incidence for cervical cancer. cervical samples from 441 females were collected from cervical cancer screening program, sexually transmitted infectious and assisted reproductive t ... | 2014 | 25132162 |
| urethral polyp-like lesions on prostatic urethra caused by chlamydia trachomatis infection: a case report. | urethral polyp is one of differential diagnoses for the male patients complain of gross-hematuria and/or hematospermia. however, there have been limited numbers of case reports including infectious etiology. here we reported clinical course and pathological findings of one rare case who was diagnosed and treated as urethral polyp-like lesions on the prostatic urethra caused by chlamydia trachomatis infection. a 25 year-old man who had a past history of frequent sexual intercourse with unspecifie ... | 2014 | 25129857 |
| differential infection outcome of chlamydia trachomatis in human blood monocytes and monocyte-derived dendritic cells. | chlamydia trachomatis is an intracellular bacteria which consist of three biovariants; trachoma (serovars a-c), urogenital (serovars d-k) and lymphogranuloma venereum (l1-l3), causing a wide spectrum of disease in humans. monocytes are considered to disseminate this pathogen throughout the body while dendritic cells (dcs) play an important role in mediating immune response against bacterial infection. to determine the fate of c. trachomatis within human peripheral blood monocytes and monocyte-de ... | 2014 | 25123797 |
| comparison of flocked and aptima swabs and two specimen transport media in the aptima combo 2 assay. | self-collected vaginal aptima swabs and flocked swabs in aptima specimen transport medium and eswabs in eswab medium detected all 37 chlamydia trachomatis-infected patients from 287 women tested by the aptima combo assay. prevalence rates of c. trachomatis, neisseria gonorrhoeae, and dual infection were 12.8%, 3.1%, and 2.4%, respectively. | 2014 | 25122855 |
| cross-sectional study of genital, rectal, and pharyngeal chlamydia and gonorrhea in women in rural south africa. | epidemiological data of genital chlamydia and gonorrhea, required to inform design and implementation of control programs, are limited for rural africa. there are no data on the prevalence of rectal or pharyngeal infections among african women. | 2014 | 25118973 |
| dynamin-mediated lipid acquisition is essential for chlamydia trachomatis development. | chlamydia trachomatis is an obligate intracellular pathogen responsible for a high burden of human disease. here, a loss-of-function screen using a set of lentivirally transduced shrnas identified 14 human host cell factors that modulate c. trachomatis infectivity. notably, knockdown of dynamin, a host gtpase, decreased c. trachomatis infectivity. dynamin functions in multiple cytoplasmic locations, including vesicle formation at the plasma membrane and the trans-golgi network. however, its role ... | 2014 | 25116793 |
| chlamydia trachomatis inhibits inducible no synthase in human mesenchymal stem cells by stimulating polyamine synthesis. | chlamydia trachomatis is considered the most common agent of sexually transmitted disease worldwide. as an obligate intracellular bacterium, it relies on the host for survival. production of no is an effective antimicrobial defense mechanism of the innate immune system. however, whether no is able to arrest chlamydial growth remains unclear. similarly, little is known about the mechanisms underlying subversion of cellular innate immunity by c. trachomatis. by analyzing protein and mrna expressio ... | 2014 | 25114102 |
| feasibility of chlamydia trachomatis screening and treatment in pregnant women in lima, peru: a prospective study in two large urban hospitals. | chlamydia trachomatis, which is asymptomatic in most women, causes significant adverse effects for pregnant women and neonates. no programmes conduct antenatal screening in latin america. we determined chlamydia prevalence, feasibility and acceptability of chlamydia screening, and adherence to treatment in pregnant women in two urban public hospitals in lima, peru. | 2015 | 25107711 |
| defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of hiv infection: a cross-sectional study. | sexually transmitted infections (sti) and bacterial vaginosis (bv) cause female genital tract inflammation. this inflammation, which is often present in the absence of symptoms, is associated with increased susceptibility to hiv infection. we aimed to evaluate genital cytokine profiles and the degree of inflammation associated with common stis and bv. | 2014 | 25107710 |
| detection of infectious organisms in archival prostate cancer tissues. | seroepidemiological studies have reported associations between exposure to sexually transmitted organisms and prostate cancer risk. this study sought dna evidence of candidate organisms in archival prostate cancer tissues with the aim of assessing if a subset of these cancers show any association with common genital infections. | 2014 | 25106851 |
| clinical characteristics associated with mycoplasma genitalium among female sex workers in nairobi, kenya. | the prevalence of mycoplasma genitalium is high in vulnerable populations of women in low-resource settings. however, the epidemiology of infection in these populations is not well established. to determine the prevalence of mycoplasma genitalium and its association with cervical cytology and other correlates, we recruited 350 female sex workers (fsw) who were 18 to 50 years old in nairobi, kenya, for a cross-sectional study. a questionnaire was administered at baseline to obtain information on ... | 2014 | 25100823 |
| frequency and risk factors for incident and redetected chlamydia trachomatis infection in sexually active, young, multi-ethnic women: a community based cohort study. | to investigate the frequency and risk factors for incident and redetected chlamydia trachomatis infection in sexually active, young, multi-ethnic women in the community. | 2014 | 25100744 |
| [clinical and immunological factors of the onset and development of age-related macular degeneration]. | the purpose of the study is to determine the role of certain clinical and immunological factors of the onset and development of age-related macular degeneration (amd). | 2014 | 25098114 |
| prevalence of chlamydia trachomatis among asymptomatic women. | chlamydia trachomatis is a ubiquitous pathogen worldwide and causes ocular. urogenital, and respiratory infections in humans. c. trachomatis infection of lower genital tract is one of the most prevalent sexually transmitted diseases (stds) in different parts of the world. their treatment, follow-up, and hopefulness for future is very important. objectives of this study were to see the prevalence of chlamydia trachomatis infection among women of child bearing age and to determine the incidence of ... | 2014 | 25098047 |
| sexually transmitted infections in women. | sexually transmitted infections (stis) are highly prevalent and cause a wide spectrum of disease. however, the majority of these infections may be unrecognized due to lack of overt signs or symptoms of infection. asymptomatic infections remain significant as a result of the potential for long-term sequelae, predominately in women, and the risks of complications during pregnancy as well as mother-to-child transmission. laboratory diagnostics play an important role in identifying infection and in ... | 2014 | 25083897 |
| [chlamydia trachomatis proteasome protein as one of the significant pathogenicity factors of exciter]. | sex-related infections are a global problem. such infections may lead to acute or chronic diseases. chlamydia trachomatis is a dangerous and widespread pathogenicity factor that is not sensitive to conventional drugs and has no obvious symptoms. protein cpaf is leading factor of pathogenesis. this protein inhibits the signaling pathways of host cell and supports long survival of the pathogen in the host cell. the goal of this work was to review general properties of the proteasome chlamydia prot ... | 2014 | 25080811 |
| relationships between diagnoses of sexually transmitted infections and urinary tract infections among male service members diagnosed with urethritis, active component, u.s. armed forces, 2000-2013. | a previous msmr report found that 42.8% of all incident (first-time) urinary tract infections (utis) in males, but only 0.4% of such utis in females, were diagnosed as "urethritis, unspecified" (icd-9: 597.80). this study explored the possibility that many of the diagnoses of urethritis in males represented sexually transmitted infections (stis), even though icd-9: 597.80 is explicitly reserved for cases of urethritis that are deemed to not be sexually transmitted. examined were relationships be ... | 2014 | 25080332 |
| protection promoted by pgp3 or pgp4 against chlamydia muridarum is mediated by cd4(+) cells in c57bl/6n mice. | urogenital tract infection with chlamydia trachomatis is a leading cause of sexually transmitted infections. there is currently no commercially available vaccine against c. trachomatis. the highly conserved plasmid of chlamydiae has been considered to be a virulence factor and the plasmid proteins have important roles in the chlamydia-specific immune response. this study was designed to evaluate the efficacy of vaccination with plasmid proteins in the prevention of c. muridarum lung infection in ... | 2014 | 25077421 |
| the dna sensor, cyclic gmp-amp synthase, is essential for induction of ifn-β during chlamydia trachomatis infection. | ifn-β has been implicated as an effector of oviduct pathology resulting from genital chlamydial infection in the mouse model. in this study, we investigated the role of cytosolic dna and engagement of dna sensors in ifn-β expression during chlamydial infection. we determined that three-prime repair exonuclease-1, a host 3' to 5' exonuclease, reduced ifn-β expression significantly during chlamydial infection using small interfering rna and gene knockout fibroblasts, implicating cytosolic dna as a ... | 2014 | 25070851 |
| screening for chlamydia infection in a sexually transmitted infection clinic: a missed opportunity? | chlamydia trachomatis (ct) infection is the most common sexually transmitted infection (sti) reported in europe. we aim to evaluate the overall prevalence of ct infection and the rate of asymptomatic infection in an sti clinic over a 5-year period. we will also discuss screening strategies with reference to attendees diagnosed with an sti and their sexual partners, and attendees with a non-infectious genital dermatosis. | 2015 | 25069382 |
| golgi fragmentation and sphingomyelin transport to chlamydia trachomatis during penicillin-induced persistence do not depend on the cytosolic presence of the chlamydial protease cpaf. | chlamydia grows inside a cytosolic vacuole (the inclusion) that is supplied with nutrients by the host through vesicular and non-vesicular transport. it is unclear in many respects how chlamydia organizes this transport. one model posits that the chlamydia-induced fragmentation of the golgi-apparatus is required for normal transport processes to the inclusion and for chlamydial development, and the chlamydial protease cpaf has been controversially implicated in golgi-fragmentation. we here use a ... | 2014 | 25068694 |
| multilocus vntr analysis-ompa typing of venereal isolates of chlamydia trachomatis in japan. | in this study, we investigated the prevalence of genital chlamydia trachomatis isolated in japan using a high-resolution genotyping method, the multilocus vntr analysis (mlva)-ompa typing method. seventeen serotypes of c. trachomatis standard strain (a-l3) and 44 clinical isolates were obtained from clinical settings. genotyping of the ompa gene allowed clinical isolates to be divided into nine serotypes: b (6.8%), d (15.9%), e (25%), f (20.5%), g (18.1%), h (6.8%), ia (2.3%), j (2.3%), and k (2 ... | 2014 | 25066435 |
| evidence of a conserved role for chlamydia htra in the replication phase of the chlamydial developmental cycle. | identification of the htra inhibitor jo146 previously enabled us to demonstrate an essential function for htra during the mid-replicative phase of the chlamydia trachomatis developmental cycle. here we extend our investigations to other members of the chlamydia genus. c. trachomatis isolates with distinct replicative phase growth kinetics showed significant loss of viable infectious progeny after htra was inhibited during the replicative phase. mid-replicative phase addition of jo146 was also si ... | 2014 | 25066238 |
| minimum spread of the new swedish variant of chlamydia trachomatis and distribution of c. trachomatis ompa genotypes in three geographically distant areas of spain, 2011-2012. | the aim of this study was to determine the presence of the new swedish chlamydia trachomatis (c. trachomatis) variant (nvct) and the distribution of c. trachomatis ompa genotypes in three geographically distant regions of spain. | 2014 | 25056129 |
| reattendance and chlamydia retesting rates at 12 months among young people attending australian general practice clinics 2007-10: a longitudinal study. | background clinical guidelines commonly recommend annual chlamydia (chlamydia trachomatis) testing in young people. general practice (gp) clinics can play an important role in annual testing, as a high proportion of young people attend these clinics annually; however, little is known about the timing of attendance and testing in this setting. | 2014 | 25054477 |
| prevalence and determinants of sexually transmitted infections in women at risk undergoing abortion in a swiss primary care setting. | specific prevalence data are needed to assess the burden of sexually transmitted infections (stis) in specific settings where data are scant, such as women seeking early termination of pregnancy (top). we aimed to investigate the prevalence of stis and its determinants in women at risk (e. g. pathological cervical swab) undergoing top in a primary care setting in switzerland. | 2014 | 25051930 |
| trachoma. | trachoma is the most common infectious cause of blindness. repeated episodes of infection with chlamydia trachomatis in childhood lead to severe conjunctival inflammation, scarring, and potentially blinding inturned eyelashes (trichiasis or entropion) in later life. trachoma occurs in resource-poor areas with inadequate hygiene, where children with unclean faces share infected ocular secretions. much has been learnt about the epidemiology and pathophysiology of trachoma. integrated control progr ... | 2014 | 25043452 |
| decoration of outer membrane vesicles with multiple antigens by using an autotransporter approach. | outer membrane vesicles (omvs) are spherical nanoparticles that naturally shed from gram-negative bacteria. they are rich in immunostimulatory proteins and lipopolysaccharide but do not replicate, which increases their safety profile and renders them attractive vaccine vectors. by packaging foreign polypeptides in omvs, specific immune responses can be raised toward heterologous antigens in the context of an intrinsic adjuvant. antigens exposed at the vesicle surface have been suggested to elici ... | 2014 | 25038093 |
| seroprevalence of antibodies against pkn1, a novel potential immunogen, in chlamydia trachomatis-infected macaca nemestrina and human patients. | chlamydia trachomatis (ct) is an important cause of sexually transmitted genital tract infections (stis) and trachoma. despite major research into chlamydial pathogenesis and host immune responses, immunoprotection has been hampered by the incomplete understanding of protective immunity in the genital tract. characterized vaccine candidates have shown variable efficacy ranging from no protection to partial protection in vivo. it is therefore a research priority to identify novel chlamydial antig ... | 2014 | 25032212 |
| design and synthesis of 3-isoxazolidone derivatives as new chlamydia trachomatis inhibitors. | chlamydia trachomatis (ct) is a bacterial human pathogen responsible for the development of trachoma, the worldwide infection leading to blindness, and is also a major cause of sexually transmitted diseases. as iron is an essential metabolite for this bacterium, iron depletion presents a promising strategy to limit ct proliferation. the aim of this study is to synthesize 3-isoxazolidone derivatives bearing known chelating moieties in an attempt to develop new bactericidal anti-chlamydiaceae mole ... | 2014 | 25027937 |
| [increase of n. gonorrhoeae, chlamydia trachomatis and ureaplasma in hiv infected individuals]. | 2014 | 25026858 | |
| epidemiology of curable sexually transmitted infections among women at increased risk for hiv in northwestern tanzania: inadequacy of syndromic management. | curable, non-viral pathogens account for a significant burden of sexually transmitted infections (stis), and there is established evidence that stis increase both hiv acquisition and transmission. we investigated the prevalence, trends, and factors associated with chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis and treponema pallidum, and the performance of syndromic management, among a cohort of women working in bars, hotels, and other food and recreational facilities near l ... | 2014 | 25025338 |
| performance of the abbott real time ct/ng assay in urines and cervico-vaginal samples from senegal. | chlamydia trachomatis and neisseria gonorrhoeae are the most common causes of sexually transmitted disease in senegal and worldwide. molecular techniques have become the standard for their detection, and due to the frequency of co-infections, these tests can detect both agents and can be used on urine samples, vaginal swabs, or endocervical samples. in developing countries, the use of these molecular techniques is very limited and there is a need for evaluations of these techniques to be done. | 2014 | 25022301 |
| molecular detection of chlamydia trachomatis and other sexually transmitted bacteria in semen of male partners of infertile couples in tunisia: the effect on semen parameters and spermatozoa apoptosis markers. | this study was undertaken to determine the prevalence of chlamydia trachomatis, mycoplasmas, and ureaplasmas in semen samples of the male partners of infertile couples and to investigate whether chlamydia trachomatis could initiate apoptosis in human spermatozoa. a total of 85 males partners of infertile couples undergoing routine semen analysis according to world health organization guidelines were included. specimens were examined for the presence of chlamydia trachomatis, neisseria gonorrhoea ... | 2014 | 25019616 |
| high-grade cervical lesions among women attending a reference clinic in brazil: associated factors and comparison among screening methods. | although screening for cervical cancer is recommended for women in most countries, the incidence of cervical cancer is greater in developing countries. our goal was to determine the prevalence and factors associated with high-grade lesions/cervical cancer among women attending a reference clinic in brazil and evaluate the correlation of histology with cytology, colposcopy and the high-risk hpv (hr-hpv) tests. | 2014 | 25019210 |
| vaginal douching and sexually transmitted infections among female sex workers: a cross-sectional study in three provinces in china. | though vaginal douching is a common practice among female sex workers that could increase the risk of hiv and adverse reproductive health outcomes, it has drawn limited attention. from november 2010 to january 2011, a convenience sample of female sex workers was recruited in three cities in china. face-to-face interviews were conducted to gather socio-demographic and behavioural information. blood samples were collected for syphilis serological tests. endo-cervical swabs were collected and teste ... | 2015 | 25015933 |
| hiv/sexually transmitted infection prevalence and sexual behavior of men who have sex with men in 3 districts of botswana: results from the 2012 biobehavioral survey. | men who have sex with men (msm) suffer significant stigma and discrimination; hence, they are reluctant to access health services. the botswana second national strategic framework for 2010-2016 stipulates the need to increase hiv prevention services for key populations as one of its prevention implementation strategies. we report here the prevalence of hiv and other sexually transmitted infections and risk factors for hiv infection among msm in botswana. | 2014 | 25013975 |
| scoring system avoids chlamydia trachomatis overscreening in women seeking surgical abortions. | to develop and validate a predictive score to avoid unnecessary screening and prophylactic antibiotic use in abortion clinics by identifying a group of women who are at very low risk for chlamydia trachomatis (ct) infection. | 2014 | 25013973 |
| should we screen heterosexuals for extra-genital chlamydial and gonococcal infections? | neisseria gonorrhoeae (gc) and chlamydia trachomatis (ct) are two of the most prevalent bacterial sexually transmitted infections in the uk. although the high burden of extra-genital infections with gc and ct in men who have sex with men has been well established, a significant number of extra-genital site infections with ct and gc could similarly be present in heterosexual women. for this reason we started to routinely offer extra-genital site testing for gc and ct in all patients attending our ... | 2015 | 25013220 |