Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| some pharmacological effects of tizanidine on smooth muscle organs and alpha 2-adrenoceptor. | microsomal and crude synaptosomal fractions were prepared from the longitudinal muscle of guinea-pig ileum. a specific binding of [3h]yohimbine (10 nm) to alpha 2-adrenoceptor in the crude synaptosomal fraction was inhibited by tizanidine and clonidine. tizanidine is about one-third as potent as clonidine. a specific binding of [3h]qnb (0.3 nm) to muscarine receptor in the microsomal fraction was inhibited by atropine (10(-8)-10(-7) m) but not by tizanidine (up to 10(-4) m). tizanidine inhibited ... | 1985 | 2996971 |
| macrophages as effector cells. introduction. | 2010 | 2996946 | |
| demonstration of a stimulatory protein for virus-specified dna polymerase in phorbol ester-treated epstein-barr virus-carrying cells. | a heat-labile epstein-barr virus-specific dna polymerase stimulatory protein having a molecular mass of 45 kda was purified from phorbol 12-myristate 13-acetate-treated p3hr-1 cells by column chromatography. the virus dna polymerase stimulatory protein was precipitated by sera from patients with nasopharyngeal carcinoma but not by sera from healthy donors. the interaction of the stimulatory protein with dna polymerase was stoichiometric. furthermore, this protein stimulated epstein-barr virus dn ... | 1985 | 2994045 |
| cyclophosphamide, doxorubicin and cisplatin chemotherapy for patients with locally advanced urothelial tumors with or without nodal metastases. | thirty-eight patients with primary urothelial tumors recurring in the pelvis or nodal presentation were treated with intravenous or intra-arterial cyclophosphamide, doxorubicin and cisplatin chemotherapy. the 38 patients were selected owing to unresectability by local criteria (12 patients) or by virtue of nodal metastases (26 patients). histologically, the patients either had pure transitional cell carcinoma (29), transformation to a histological subtype of transitional cell carcinoma (7) or pu ... | 2010 | 2993671 |
| synthesis, export, and assembly of aeromonas salmonicida a-layer analyzed by transposon mutagenesis. | suicide plasmid pjb4ji, containing transposon tn5 and phage mu, was introduced into aeromonas salmonicida 449 which produces a surface protein array known as the a-layer. kanamycin-resistant exconjugants of 449 with altered ability to produce the a-layer were selected by virtue of their altered colonial morphology and color on medium containing the dye congo red. analysis of culture supernatants, periplasmic shock fluid, outer membranes, and whole-cell lysates by sodium dodecyl sulfate-polyacryl ... | 1985 | 2993248 |
| effect of epidermal growth factor on synthesis of prostaglandins and cyclic amp by embryonic palate mesenchymal cells. | the influence of epidermal growth factor (egf) on the ability of murine embryonic palate mesenchymal (mepm) cells to be stimulated to synthesize camp and prostaglandins was investigated. preincubation of mepm cells with egf enhanced, in a dose-dependent fashion, (1) the responsiveness of mepm cells to prostaglandin e1-induced elevation of intracellular levels of camp, and (2) the responsiveness of cells to calcium ionophore (a23187) and melittin-induced synthesis of prostaglandins e2 and f2 alph ... | 2010 | 2992494 |
| granular cell myoblastoma of the breast. | 2010 | 2991509 | |
| middle tumor antigen of polyomavirus transformation-defective mutant ng59 is associated with pp60c-src. | we have found that lysis of mouse embryo cells infected with the polyomavirus host range transformation-defective (hr-t) mutant ng59 under gentle conditions that avoid ionic detergents results in detectable ng59-encoded middle tumor antigen (mtag) associated with pp60c-src. this mtag-pp60c-src complex could be immunoprecipitated from ng59-infected cell lysates by either sera from animals bearing polyomavirus-induced tumors or by monoclonal antibodies directed against mtag. immune complex kinase ... | 1985 | 2981329 |
| properties of an interphotoreceptor retinoid-binding protein from bovine retina. | washes and extracts of frozen and fresh cattle retina contain a water-soluble high-molecular-weight, retinoid-binding protein that is distinct from three other retinoid-binding proteins previously isolated from this tissue. the protein can be purified to apparent homogeneity from retinal homogenates by a combination of gel filtration, lectin, and ion-exchange chromatography. overestimation of the protein molecular weight was observed in several systems involving migration of the protein through ... | 1985 | 2981203 |
| technique for measurement of one-dimensional instantaneous ablation velocity. | an oscillating mirror scanned a he-ne laser beam along the length of a thin rod while the rod was ablated by an argon laser beam. the shadow of the scanning beam on an image plane provides a picture of the instantaneous ablation velocity of the rod. this configuration provides a unique method for investigating one-dimensional ablation. | 2010 | 2976448 |
| [how can bivalves continue to close the shells?--regulation and a molecular mechanism on the economical catch contraction]. | 2010 | 2976172 | |
| [current approaches to immunological diagnosis of autoimmune and immune complex diseases]. | 2010 | 2974642 | |
| immunoglobulin binding by the regular surface array of aeromonas salmonicida. | the cell surface of aeromonas salmonicida is covered by a regular surface array composed of a single species of protein, the a-protein (phipps, b. m., trust, t. j., ishiguro, e. e., and kay, w. w. (1983) biochemistry 22, 2934-2939). the array, known as the a-layer, is the key virulence factor for this organism. cells containing the a-layer specifically bound rabbit igg and human igm with high affinity (kd = 1.0 x 10(-6) m and 3.3 x 10(-6) m, respectively), but neither isogenic a-protein-deficien ... | 1988 | 2967820 |
| gender differences in variables associated with psychosocial adjustment to a burn injury. | the purpose of this study was to determine whether variables associated with psychosocial adjustment to a burn injury vary by gender. male and female burned subjects (n = 260) were compared on their functional disability, disfigurement, coping responses, social resources, and psychosocial adjustment to a burn injury. both men and women had adjusted psychosocially to their burn injury. less functional disability (r = .57, p less than .001) for men and greater problem-solving (r = .57, p less than ... | 2010 | 2964678 |
| applicability of coagglutination test for detecting aeromonas salmonicida antigens from extracts of bacterial cultures and experimentally infected tissues of the common carp (cyprinus carpio l.). | 1986 | 2953200 | |
| differential effects of serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. | the present study was designed to investigate the effect of distinct serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. low doses of the selective 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (5.0-500.0 micrograms/kg, i.p.) and ipsapirone (tvx q 7821; 0.5-2.5 mg/kg, i.p.), and of the 5-hydroxytryptamine (5-ht) agonist mk-212 (2.0 mg/kg, i.p.), did not elevate plasma renin activity (pra) and concentration (prc) 30 min postinjection. ... | 1987 | 2952898 |
| differential effects of serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. | the present study was designed to investigate the effect of distinct serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. low doses of the selective 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (5.0-500.0 micrograms/kg, i.p.) and ipsapirone (tvx q 7821; 0.5-2.5 mg/kg, i.p.), and of the 5-hydroxytryptamine (5-ht) agonist mk-212 (2.0 mg/kg, i.p.), did not elevate plasma renin activity (pra) and concentration (prc) 30 min postinjection. ... | 1987 | 2952898 |
| functional domains of the yeast regulatory protein gal4. | in the yeast saccharomyces cerevisiae regulation of the galactose/melibiose regulon rests on a dosage-dependent functional interplay between the positive regulator of transcription, the gal4 protein, and the negative regulator, gal80 protein. we have used this interplay to select in vitro generated fusions between the yeast adh1 promoter and gal4 coding sequence that overproduce gal4 protein, allowing the identification of gal4 protein in crude extracts from yeast. one type of these construction ... | 1986 | 2944111 |
| electrostatic mechanism of survival of virulent aeromonas salmonicida strains in river water. | the ecological mechanism of survival of aeromonas salmonicida, the bacterial pathogen of fish furunculosis, in river water was investigated by laboratory-based experiments with two virulent strains (which were autoagglutinating) and two virulent strains (which were nonagglutinating). a difference in net electrical charge of a. salmonicida cells was detected by electrophoresis; cells of the virulent strains were negative, whereas cells of the avirulent strains were positive. despite the loss of v ... | 1986 | 2942106 |
| minimal incision techniques for digital deformities. | we have presented basic minimal incision approaches to the more common digital deformities. we feel that with proper evaluation of the deformity and the patient, minimal incision surgery techniques give excellent long-term results with several advantages. these advantages include: less discomfort due to less surgical dissection. less need for internal fixation by careful use of compression dressings in the immediate postoperative period along with early ambulation. less disability. compression d ... | 2010 | 2937517 |
| catecholamine release and potentiation of thromboxane a2 production by nicotine in the greyhound. | thromboxane a2 was generated by infusing arachidonic acid (2.5 micrograms ml-1) into an extra-corporeal circuit of blood withdrawn from anaesthetized dogs, and assayed on a blood-bathed bioassay cascade of porcine and bovine coronary artery strips, chick rectum and rat stomach strip. all tissues except chick rectum were treated with phentolamine and propranolol to abolish direct effects of catecholamines. the arachidonate-induced contractions of artery strips were abolished by a thromboxane synt ... | 1986 | 2937502 |
| [changes in several indices of the hemostatic system in patients with genital cancer during the postoperative period]. | 2010 | 2935038 | |
| coronary angioplasty in myocardial infarction. | 2009 | 2933946 | |
| oesophageal motility and lower oesophageal sphincter competence in progressive systemic sclerosis and localized scleroderma. | oesophageal motility and lower oesophageal sphincter (los) competence were investigated in 13 patients with progressive systemic sclerosis (pss) and in 16 patients with localized scleroderma (ls) by means of oesophageal manometry and 24-h ph monitoring of the distal oesophagus. results were compared with those of a control group consisting of asymptomatic volunteers. marked abnormalities in oesophageal motility and in acid exposure in the distal oesophagus were observed in pss patients only. the ... | 2010 | 2928728 |
| rigid fixation and bone grafts in craniofacial surgery. | 2010 | 2924485 | |
| synthesis of glycoconjugates derived from various lipopolysaccharides of the vibrionaceae family. | conjugation of simple ketoses (such as 3-deoxy-d-manno-2-octulosonic acid and n-acetylneuraminic acid) and of various o-specific polysaccharides (from aeromonas hydrophila and aeromonas salmonicida) to the bifunctional spacer 1,6-hexanediamine, was achieved by reductive amination. the saccharide--1-(6-amino)-hexane alkyamines obtained were converted into the corresponding isothiocyanate derivatives and coupled to the free epsilon-amino group of lysine residues of the protein carrier bovine serum ... | 1989 | 2920731 |
| three-dimensional structure of an open form of the surface layer from the fish pathogen aeromonas salmonicida. | cell-free culture supernatants of a lipopolysaccharide (lps) o-polysaccharide-deficient, single-insertion transposon mutant of the tetragonal surface protein array (s layer)-containing fish pathogen aeromonas salmonicida were examined by electron microscopy. negative staining showed that the s layer was released as sheets of tetragonal material, indicating that although surface retention of assembled s layer requires the presence of wild-type lps oligosaccharides, initial assembly of s-layer sub ... | 1989 | 2914846 |
| the role of central- and peripheral-type benzodiazepine receptors in anxiolytic-agent augmentation of nacl solution intake: effects of clonazepam and ro 5-4864. | two 1,4 benzodiazepines bind preferentially to the central- and peripheral-type benzodiazepine receptor in the brain, clonazepam and ro 5-4864, respectively. they were administered to rats to determine if the relation between known anxiolytic action and efficacy in augmenting nacl solution ingestion in rehydrating rats would remain the case for these prototypic agents. clonazepam (0.062-32.0 mg/kg, po) was highly potent and efficacious and increased 1.5% nacl solution intake in a dose-related fa ... | 1988 | 2905471 |
| effect of oversulphated chondroitin and dermatan sulphate upon thrombin and factor xa inactivation by antithrombin iii or heparin cofactor ii. | the kinetics of inhibition of human thrombin and factor xa by antithrombin iii or heparin cofactor ii were examined under pseudo-first-order conditions as a function of the concentration of naturally occurring oversulphated chondroitin and dermatan sulphates. the sulphated glycosaminoglycans (gags) studied were chondroitin sulphate d (csd) (glca-2-so4-galnac-6-so4), chondroitin sulphate k (csk) (glca-3-so4-galnac-4-so4), chondroitin sulphate h (csh) (ida-galnac-4,6-diso4) and polysulphated derma ... | 1988 | 2902851 |
| importance of pulmonary blood volume and aortic blood pressure in regulation of left ventricular function. | 1988 | 2900297 | |
| mechanism of action of somatostatin in the hippocampal slice. | 1987 | 2888131 | |
| congenital adrenal hyperplasia. | 2010 | 2887945 | |
| preserved hearing following excision of acoustic tumours. | 2008 | 2885629 | |
| is vasoactive intestinal polypeptide the principal transmitter involved in human penile erection? | previous work from this laboratory reported on the effects of several autacoids and other agents on strips of human corpus cavernosum (cc) muscle. these investigations indicated the presence in the cc muscle of a) atropine-sensitive cholinoceptors, b) alpha- and beta-adrenoceptors and c) a non-adrenergic non-cholinergic mechanism. several recent publications have presented evidence in support of the possibility that vasoactive intestinal polypeptide (vip) is an important, or the chief, transmitt ... | 1986 | 2868132 |
| neural and pavlovian influences on immunity. | the traditional view that the nervous and immune systems are functionally independent (aside from general stress effects and autoimmune disorders of the nervous system) is being challenged by a new view that the nervous system regulates the activity of the immune system. if this is true, it should be possible to change the activity of the immune system by means of pavlovian conditioning, just as it is possible to condition other physiological events influenced by the autonomic nervous system or ... | 1985 | 2866484 |
| preparation of low-density "endosome" and "endosome"-depleted golgi fractions from rat liver. | 1985 | 2859513 | |
| [chorioadenoma destruens. presentation of a case and review of the literature]. | 2009 | 2856452 | |
| [the entero-insular axis: the new incretin candidate glucagon-like peptide-1(7-36)amide (glp-1(7-36))amide]. | the functional connection between the gut and pancreatic islets is described by the term "enteroinsular axis". a humoral factor of the gut that might enhance the glucose-induced secretion of insulin is named "incretin". for many years glucose-dependent insulin-releasing polypeptide (gip) was the strongest incretin candidate. however, recent evidence suggests that glucagon-like peptide-1(7-36)amide represents a more potent physiological incretin. the sequence of glp-1 is identical in various mamm ... | 1988 | 2849249 |
| analysis of a large cluster of nonessential genes deleted from a vaccinia virus terminal transposition mutant. | the principal objectives of this study were to analyze the structure and coding potential of a long segment of dna missing from a previously isolated (b. moss, e. winters, and j. a. cooper (1981) j. virol. 40, 387-395) attenuated variant of vaccinia virus strain wr and to examine the precise changes in the genome accompanying the deletion. the sequences of a 14.5-kbp region located at the left end of the standard vaccinia virus genome, extending from within the inverted terminal repetition (itr) ... | 1988 | 2849238 |
| influence of immunomodulatory agents on bovine humoral and cellular immune responses to parenteral inoculation with bovine rotavirus vaccines. | sodium diethyldithiocarbamate (dtc), mycobacterium cell wall extract (mcwe, regressin), killed corynebacterium parvum (c. parvum, immunoregulin) and muramyldipeptide (mdp) were each combined with purified, live bovine rotavirus and inoculated into 3 month-old holstein-friesian calves in order to examine their ability to potentiate specific humoral and cellular immune responses. the vaccinated calves were boosted twice at 3 and 6 weeks after initial vaccine inoculation. the rotavirus was administ ... | 1988 | 2847397 |
| a naturally immunogenic virion-associated protein specific for hiv-2 and siv. | the genomic organization of hiv-1 and the family of hiv-2 and siv viruses is similar. however, there is an open reading frame, orf-x, that is present in hiv-2 and siv, but not in hiv-1. the extent of protein sequence conservation in orf-x between hiv-2rod and sivmac suggests that this open reading frame encodes a gene that may be important for infectivity or replication. here, we show that the orf-x products of sivmac and hiv-2sbl-6669 are virion-associated and that the introduction of a prematu ... | 1988 | 2842694 |
| a naturally immunogenic virion-associated protein specific for hiv-2 and siv. | the genomic organization of hiv-1 and the family of hiv-2 and siv viruses is similar. however, there is an open reading frame, orf-x, that is present in hiv-2 and siv, but not in hiv-1. the extent of protein sequence conservation in orf-x between hiv-2rod and sivmac suggests that this open reading frame encodes a gene that may be important for infectivity or replication. here, we show that the orf-x products of sivmac and hiv-2sbl-6669 are virion-associated and that the introduction of a prematu ... | 1988 | 2842694 |
| drug-induced place preference in rats with 5,7-dihydroxytryptamine lesions of the nucleus accumbens. | the conditioned place preference (cpp) paradigm was used to determine a role for serotonin in the nucleus accumbens in the mediation of the rewarding properties of d-amphetamine morphine and diazepam. the effect of these drugs on cpp was examined in controls and in animals with 5,7-dihydroxytryptamine lesions of the nucleus accumbans. the results from control animals confirmed that d-amphetamine (1.5 mg/kg, i.p.), morphine (2.0 mg/kg, i.p.) and diazepam (1.0 mg/kg, i.p.) produced place preferenc ... | 1988 | 2840924 |
| first available results of long-term carcinogenicity bioassay on detergency zeolites (ms 4a and ms 5a). | long-term experimental carcinogenicity bioassay was carried out on ms 4a and ms 5a zeolites. the materials were tested on sprague-dawley rats by intraperitoneal, intrapleural, and subcutaneous injection of 25 mg in 1 ml of h2o. the results of this bioassay (the onset of one peritoneal mesothelioma in a male rat treated by intraperitoneal injection of zeolite ms 4a) calls for further and more sophisticated tests on zeolites used as detergents. | 1988 | 2839094 |
| mechanism of the epsp synthase catalyzed reaction: evidence for the lack of a covalent carboxyvinyl intermediate in catalysis. | in order to detect covalent reaction intermediates in the 5-enolpyruvylshikimate-3-phosphate (epsp) synthase reaction, we have investigated the interaction of epsp synthase with the reaction product epsp. an exchange of epsp-methylene protons could be demonstrated by incubating epsps with epsp in d2o. since trace amounts of contaminating pi would lead to reversal of epsps reaction and hence methylene proton exchange, we added pyruvate kinase, adp, mg++ and k+. under these conditions, any contami ... | 1988 | 2838023 |
| individual responses to converting enzyme inhibitors and calcium antagonists. | this study was designed to assess whether the acute blood pressure response of an individual hypertensive patient to a calcium antagonist or an angiotensin converting enzyme (ace) inhibitor is a good predictor of the long-term efficacy of these drug classes in this particular patient. the concept that good responses to ace inhibitors and calcium antagonists may be mutually exclusive was also tested. sixteen patients were included in a randomized crossover trial of enalapril, 20 mg daily, and dil ... | 2010 | 2830189 |
| effects of polymyxin b nonapeptide on aeromonas salmonicida. | in contrast to polymyxin b-susceptible gram-negative bacteria of human origin, the fish pathogen aeromonas salmonicida was resistant to sensitization by polymyxin b nonapeptide (pmbn) to hydrophobic antibiotics. similarly, sensitization of a. salmonicida strains by pmbn to the bactericidal action of brook trout (salvelinus fontinalis) serum complement was less pronounced than the similar effect of pmbn against other gram-negative bacteria in certain mammalian sera. the surface array protein (a l ... | 1987 | 2823698 |
| construction of an excretion vector and extracellular production of human growth hormone from escherichia coli. | a new excretion vector, peap8, was constructed to develop an excretion system for escherichia coli. this plasmid, derived from peap37, carried the weakly activated kil gene of plasmid pmb9 [kobayashi et al., j. bacteriol. 166 (1986) 728-732] and the penicillinase promoter and signal region of an alkalophilic bacillus sp. to excrete foreign gene products. a gene for human growth hormone (hgh) was joined to this signal sequence through the hindiii site. the recombinant plasmid p8hgh1 thus construc ... | 1987 | 2820841 |
| [visualization of forensically important foreign bodies by direct roentgen magnification]. | the detection of foreign bodies of microscopic dimensions with radiographic techniques is limited by the size and density of the particle and the radiographic resolution. these restrictions can be of decisive value in case work. the high grade direct radiographic magnification technique was successfully used in preceding experiments. due to its 1 mu focal spot, this tube allows direct magnifications up to 250 times. in present studies, the advantages as well as the limitations of this new techni ... | 1989 | 2818477 |
| [visualization of forensically important foreign bodies by direct roentgen magnification]. | the detection of foreign bodies of microscopic dimensions with radiographic techniques is limited by the size and density of the particle and the radiographic resolution. these restrictions can be of decisive value in case work. the high grade direct radiographic magnification technique was successfully used in preceding experiments. due to its 1 mu focal spot, this tube allows direct magnifications up to 250 times. in present studies, the advantages as well as the limitations of this new techni ... | 1989 | 2818477 |
| response properties of normal observers and patients during automated perimetry. | automated perimetry was performed on both eyes of 54 normal subjects, 36 patients with ocular hypertension and normal visual fields, and 20 patients with early glaucomatous visual field loss to evaluate false-positive errors, false-negative errors, fixation losses, consistency of double determinations, and testing time. for all subject groups and response measures, large interindividual variation was found. no meaningful age-related changes were obtained for false-negative errors, false-positive ... | 2009 | 2818281 |
| response properties of normal observers and patients during automated perimetry. | automated perimetry was performed on both eyes of 54 normal subjects, 36 patients with ocular hypertension and normal visual fields, and 20 patients with early glaucomatous visual field loss to evaluate false-positive errors, false-negative errors, fixation losses, consistency of double determinations, and testing time. for all subject groups and response measures, large interindividual variation was found. no meaningful age-related changes were obtained for false-negative errors, false-positive ... | 2009 | 2818281 |
| proton motive force involved in protein transport across the outer membrane of aeromonas salmonicida. | many gram-negative bacteria export proteins to the exterior. some of these proteins are first secreted into the periplasm and then cross the outer membrane in a separate step. the source of energy required for the translocation is unknown. export of the extracellular protein proaerolysin from the periplasm through the outer membrane of aeromonas salmonicida is inhibited by a proton ionophore and by low extracellular ph. one possible explanation of these results is that a proton gradient across t ... | 1989 | 2814486 |
| [a dynamic model of the interaction of cones with bright horizontal cells in the carp retina]. | the dynamic model showing interaction between cones and l-type horizontal cells in the carp retina is discussed. the model is based on the intracellular recording of spectral responses of horizontal cells. the model equations describe the contribution of ionic channels to responses of cones and horizontal cells. the model permits predicting responses of photopic l-cells as a function of time. | 2009 | 2812137 |
| [a dynamic model of the interaction of cones with bright horizontal cells in the carp retina]. | the dynamic model showing interaction between cones and l-type horizontal cells in the carp retina is discussed. the model is based on the intracellular recording of spectral responses of horizontal cells. the model equations describe the contribution of ionic channels to responses of cones and horizontal cells. the model permits predicting responses of photopic l-cells as a function of time. | 2009 | 2812137 |
| "a few bad apples?". | 2009 | 2812134 | |
| "a few bad apples?". | 2009 | 2812134 | |
| clinical and histopathologic correlation in patients with dilated cardiomyopathy. value of force-velocity product. | to evaluate the relation between cardiac function and myocardial damage in patients with dilated cardiomyopathy (dcm), we compared echocardiographic parameters and histopathologic findings of the biopsied myocardium in 50 cases with dcm. as wall motion is much influenced by the increased afterload in cases with large ventricles, we generated a new contractile parameter, force-velocity product (fvp). fvp was defined as the result obtained by multiplying mean circumferential fiber shortening veloc ... | 1999 | 2810763 |
| more on index of refraction. | 2009 | 2805311 | |
| more on index of refraction. | 2009 | 2805311 | |
| dengue haemorrhagic fever/dengue shock syndrome: lessons from the cuban epidemic, 1981. | dengue haemorrhagic fever/dengue shock syndrome (dhf/dss) is one of the principal causes of hospitalization and death among children in several south-east asian countries. also, in the region of the americas, there has been an increase in the frequency of dengue fever epidemics and in the number of cases of dhf/dss. in 1981 an epidemic of dengue haemorrhagic fever occurred in cuba and this suggests that there is a high risk that such epidemics could recur in the region. the article summarizes th ... | 2009 | 2805215 |
| dengue haemorrhagic fever/dengue shock syndrome: lessons from the cuban epidemic, 1981. | dengue haemorrhagic fever/dengue shock syndrome (dhf/dss) is one of the principal causes of hospitalization and death among children in several south-east asian countries. also, in the region of the americas, there has been an increase in the frequency of dengue fever epidemics and in the number of cases of dhf/dss. in 1981 an epidemic of dengue haemorrhagic fever occurred in cuba and this suggests that there is a high risk that such epidemics could recur in the region. the article summarizes th ... | 2009 | 2805215 |
| the effect of an additional task on sensorimotor performance in schizophrenics and neurotics. | 2009 | 2800955 | |
| greed in healthcare. | 2009 | 2798274 | |
| greed in healthcare. | 2009 | 2798274 | |
| effect of recombinant human granulocyte colony-stimulating factor on pneumocystis carinii infection in nude mice. | repeated subcutaneous (s.c.) injections of recombinant human granulocyte colony-stimulating factor (rhg-csf) to pneumocystis carinii (p. carinii)-infected balb/c nude (nu/nu) mice had no effects on the number of the p. carinii cysts in the lungs, despite neutrophilic infiltration in the tissues and a marked increase in blood neutrophil count. this finding indicates that neutrophils in the absence of t cells do not play an important role in the killing of p. carinii. however, survival periods of ... | 1989 | 2787431 |
| [single photon emission computed tomography by using n-isopropyl-p-[123i]-iodoamphetamine and 99mtc-hexamethyl propyleneamine oxime in a patient with herpes simplex encephalitis]. | single photon emission computed tomographies (spects) by using n-isopropyl-p-[123i-imp]-iodo-amphetamine (123i-imp) and 99mtc-hexamethyl propyleneamine oxime (99mtc-hm-pao) were serially performed in a 70 yrs. old male with herpes simplex encephalitis (hse), and the chronological changes of accumulations were studied. accumulations of both 123i-imp and 99mtc-hm-pao increased initially, and then decreased with the stage of hse being advanced. the sequential appearance of the lesion in hse with 12 ... | 2009 | 2786584 |
| production of human cells expressing individual transferred hla-a,-b,-c genes using an hla-a,-b,-c null human cell line. | we detail in this report the characterization of a human b-lymphoblastoid cell line, .221, that does not express endogenous hla-a, hla-b, or hla-c class i ag due to gamma-ray-induced mutations in the hla complex. mutant .221 is characterized by: 1) complete absence of hla-a,-b,-c mrna transcripts and alpha-chains, and 2) intracellular expression of two non-a,-b,-c class i alpha-chains with an abundance less than or equal to 1% of normal hla-a,-b,-c expression on similar cells. however, transferr ... | 1989 | 2785140 |
| opening remarks of president fernando e. agrait on the occasion of the 50th anniversary of the cayo santiago macaque colony. | 1989 | 2780954 | |
| ultrastructural study of the response of eosinophil granule cells to aeromonas salmonicida extracellular products and histamine liberators in rainbow trout salmo gairdneri richardson. | intraperitoneal injections of aeromonas salmonicida extracellular products (ecp), compound 48/80 and concanavalin a were found to degranulate the eosinophil granule cells (egc) in the lower intestine and rectum of the rainbow trout salmo gairdneri richardson. ultrastructurally, the egc response resembled the anaphylactic granule extrusion of mammalian mast cells. varying degrees of granule vacuolation and loss of electron density occurred. labyrinthine channels were observed at the peak of degra ... | 1989 | 2776934 |
| time-resolved fluorescence study of vu-9 calmodulin, an engineered calmodulin possessing a single tryptophan residue. | an engineered calmodulin (vu-9 calmodulin), which possesses a single tryptophan residue at position 99 in calcium binding domain iii, was studied by time-resolved fluorescence. at least two exponential terms are needed to describe the tryptophan fluorescence decays, either in the presence or in the absence of calcium. the characteristics of the fluorescence decays are strongly dependent upon the number of calcium ions bound per molecule of vu-9 calmodulin until half of the calcium sites are occu ... | 2009 | 2775754 |
| [epidemiology of brucellosis. retrospective study of 246 hospital cases]. | 246 cases of brucellosis registered by the medicine preventive service of miguel servet hospital for the period 1981-87 are retrospectively studied. it emphasizes the consumption of non controlled dairy products as the most frequent (54.5%) risk factor. a greater prevalence of professional and contact with cattle risk factors are observed in the male patients coming from rural areas. | 1989 | 2772348 |
| unexpected sex-ratios in families of language/learning-impaired children. | there is a well-documented propensity of males affected with developmental language/learning impairment. results from this study demonstrate, unexpectedly, that this sex-ratio difference of males to females with developmental language/learning disorders was found to occur significantly only in families with a language/learning-impaired mother. in addition, a remarkably aberrant offspring sex-ratio was found in families of language/learning-impaired children who had an affected mother, but not fa ... | 2009 | 2771037 |
| endothelium-dependent inhibition of ergonovine-induced contraction is impaired in porcine coronary arteries with regenerated endothelium. | the inhibitory effects of the endothelium against ergonovine-induced contraction were examined in isolated porcine coronary arteries under normal conditions and after endothelial regeneration. endothelium-dependent responses were examined in vitro in normal yorkshire pigs (n = 16) and in pigs that had undergone balloon endothelium removal of the left anterior descending coronary artery (lad) 4 weeks before the study (n = 10). the presence of a complete endothelial lining was confirmed histologic ... | 1989 | 2766515 |
| thermodynamics of intersubunit interactions in cholera toxin upon binding to the oligosaccharide portion of its cell surface receptor, ganglioside gm1. | the binding and the energetics of the interaction of cholera toxin with the oligosaccharide portion of ganglioside gm1 (oligo-gm1), the toxin cell surface receptor, have been studied by high-sensitivity isothermal titration calorimetry and differential scanning calorimetry. previously, we have shown that the association of cholera toxin to ganglioside gm1 enhances the cooperative interactions between subunits in the b-subunit pentamer [goins, b., & freire, e. (1988) biochemistry 27, 2046-2052]. ... | 2009 | 2765522 |
| [break with a good examination tradition]. | 2009 | 2763101 | |
| 2-bromo- and 16-bromo-estrogens and related compounds: potential inhibitors for both estradiol 2- and 16 alpha-hydroxylases in rat liver microsomes. | kinetic studies of inhibition of estradiol 2- and 16 alpha-hydroxylase activities in male rat liver microsomes with 2-bromoestrogens, 4-bromo-estrone (4-bre1), 16 alpha- and 16 beta-bromoestrones and 16 beta-acetylthioestrone (16-acse1) were carried out. 2-bromoestrogens and 4-bre1 nonspecifically blocked the two enzyme activities in a competitive manner, and 2-bromo-estradiol (2-bre2) was the most potent inhibitor for the two hydroxylases among the 2- and 4-bromo steroids. kinetic data, the app ... | 1989 | 2761259 |
| relationship between concentration and anticonvulsant effect of phenytoin against electroshock-induced seizures in rats: comparison of sampling sites for concentration determinations. | the purpose of this investigation was to determine the optimum sampling site for phenytoin concentration measurements in the context of pharmacodynamic studies of the anticonvulsant effect of phenytoin. determination of drug concentrations in the serum, serum water, brain, and cerebrospinal fluid (csf) of rats as a function of time after iv injection of a 6-mg/kg dose revealed a significant disequilibrium between brain and serum water for 15 min and between csf and serum water for 5 min after in ... | 1989 | 2760817 |
| the dispersion of echinococcus granulosus in the intestine of dogs. | we studied the dispersion of adult echinococcus granulosus in the intestine of experimentally infected dogs at 2 scales of habitat use. on a coarse scale, worms were found most frequently in the anterior third of the small intestine. on a fine scale, clumps or aggregations, typically of 4-5 worms in an area of 12 mm2, occurred throughout the anterior two-thirds of the intestine. the most likely proximate cause of aggregative behavior is attraction between individual worms. there are at least 2 e ... | 1989 | 2760768 |
| the dispersion of echinococcus granulosus in the intestine of dogs. | we studied the dispersion of adult echinococcus granulosus in the intestine of experimentally infected dogs at 2 scales of habitat use. on a coarse scale, worms were found most frequently in the anterior third of the small intestine. on a fine scale, clumps or aggregations, typically of 4-5 worms in an area of 12 mm2, occurred throughout the anterior two-thirds of the intestine. the most likely proximate cause of aggregative behavior is attraction between individual worms. there are at least 2 e ... | 1989 | 2760768 |
| identification and characterization of an 8-kd peptide stimulating late erythropoiesis. | chronic renal failure is often associated with severe anemia, subnormal levels of erythropoietin (epo), and the presence of erythropoietic inhibitors. we studied an anephric patient with polycystic kidney disease maintaining a hemoglobin level of 13-14 g. biochemical, endocrine, and hematological parameters were all within normal limits. epo levels examined on two occasions during the clinical investigation were found to be low to subnormal. plasma of this patient supported human bone marrow ery ... | 1989 | 2753086 |
| effects of systemic morphine upon a delta- and c-fibre evoked activities of subnucleus reticularis dorsalis neurones in the rat medulla. | the effects of intravenous administration of morphine were examined on a delta- and c-fibre evoked activities of subnucleus reticularis dorsalis (srd) neurones in the rat medulla. this region may have an important role in nociception since srd neurones exhibit whole body receptive fields from which they can be activated preferentially or exclusively by noxious stimulation. the present study demonstrates that morphine can depress the c-fibre evoked responses of srd neurones in a dose-related (3-1 ... | 1989 | 2753082 |
| human gastric lipase. the n-terminal tetrapeptide is essential for lipid binding and lipase activity. | human gastric lipase subjected to limited tryptic proteolysis lost its ability to hydrolyze emulsified long-chain triacylglycerol. activity against a water-soluble substrate was however retained, indicating that proteolysis did not affect the active site. sequence analysis revealed that trypsin specifically cleaved the linkage between lysine-4 and leucine-5. this cleavage rendered the enzyme unable to bind to emulsified triacylglycerol particles, e.g. human milk fat globules. we suggest that the ... | 1989 | 2753032 |
| biomechanical considerations on some postoperative problems of directly anchored total hip replacements. | uncemented total hip replacements have resulted in a higher incidence of postoperative complaints than cemented ones. the theoretical explanation of these not well defined discomforts is based on the differences of the stress and strain fields around the distal portions of the femoral components. while the noncemented stems are press-fitted and most of them tapered distally, thus creating hoop stresses and strains in the surrounding cortical bone, the shrinkage of the cement prevents these mecha ... | 2009 | 2738082 |
| [imbecility of moderate degree in schoolchildren]. | the data of an experimental psychological investigation and self-service skills acquisition are presented for children with slight imbecility in three age groups: junior, middle and senior school-age. the peculiarities of the course of mental functions are discussed and potential intellectual capacities assessed in terms of the social and labor rehabilitation. | 2009 | 2728743 |
| genetic and biochemical characterization of the thymidine kinase gene from herpesvirus of turkeys. | the thymidine kinase gene encoded by herpesvirus of turkeys has been identified and characterized. a viral mutant (atr0) resistant to 1-beta-d-arabinofuranosylthymine was isolated. this mutant was also resistant to 1-(2-fluoro-2-deoxy-beta-d-arabinofuronosyl)-5-methyluracil and was unable to incorporate [125i]deoxycytidine into dna. the mutant phenotype was rescued by a cloned region of the turkey herpesvirus genome whose dna sequence was found to contain an open reading frame similar to that fo ... | 1989 | 2724415 |
| uncertainty and visual strategies in table tennis. | ball games are characterized by perceptual uncertainty and time-pressure. of interest is the visual-search pattern carried out when these characteristics change. this is the case in table-tennis situations when comparing a drill situation, when one kind of stroke is constantly repeated, and a match situation, when the stroke is more often unpredictable. we analysed, during play, the visual-search pattern of five expert table tennis players to examine the effect of uncertainty on visual behavior. ... | 2009 | 2717357 |
| incidence and causes of sepsis in glucose-6-phosphate dehydrogenase-deficient newborn infants. | to determine the susceptibility to sepsis in newborn infants deficient in glucose-6-phosphate dehydrogenase (g6pd), we screened 33,943 saudi arab infants. deficiency of g6pd was found in 18%. sepsis was determined by the presence of clinical signs of sepsis and confirmed by positive blood cultures. sepsis was documented in 75 infants (2.2/1000). the incidence of sepsis was significantly higher in 6138 g6pd-deficient infants (3.4/1000) than in the 27,805 with normal g6pd activity (1.9/1000; p les ... | 2009 | 2715888 |
| determination of stereo- and positional isomers of oxygenated triterpenoids by reversed phase high performance liquid chromatography. | twenty four oxygenated triterpenoids, including eight pairs of stereoisomers and five pairs of positional isomers, could be separated by reversed phase hplc. the capacity factors obtained in methanol-water and acetonitrile-water solvent systems made it possible to correlate the molecular polarities due to the presence of multiple oxygenated functional groups in these compounds. it was found that the number and position of functional groups as well as the stereochemistry of these functional group ... | 2009 | 2715731 |
| the influence of type of tube and experience of the operator on performance of small bowel enema. | seventy patients underwent small bowel enema (sbe) to assess the influence of experience of the radiologist on the ease of jejunal intubation and the adequacy of sbe using two types of tubes. comparing intubation time, intubation screening time, total screening time and total room time, we conclude that jejunal intubation is achieved easily, in a reasonable time with both types of tube, by all grades of radiologist, although the experienced operator using the silk tube achieved intubation in a s ... | 2009 | 2713604 |
| evaluation of infant feeding in acute gastroenteritis. | sixty-eight bottle-fed babies under 9 months of age with mild acute gastroenteritis were observed to evaluate current feeding regimens following acute gastroenteritis in infancy. all babies were fed for 24 h with a glucose-electrolyte mixture (gem) and then randomly assigned to either a gradual reintroduction to their normal milk, i.e., slow regrade; immediate return to full-strength formula; or a rapid regrade to a hypoallergenic whey hydrolysate formula. all groups were well matched for age, s ... | 2009 | 2709254 |
| extracellular secretion of cloned aerolysin and phospholipase by aeromonas salmonicida. | the promoterless structural genes for aerolysin and the extracellular phospholipase of aeromonas hydrophila were inserted into a multi-host-range expression vector and transferred into aeromonas salmonicida and escherichia coli. in both species, gene expression was under the control of the inducible tac promoter of the vector. neither the phospholipase nor the aerolysin was released by intact e. coli. instead, both proteins accumulated in the periplasm, leading to reduced growth and eventual cel ... | 1989 | 2708312 |
| mechanical, biochemical, and structural effects of vitamin d deficiency on the chick heart. | the effects of vitamin d deprivation on the chick heart were investigated from three aspects: cardiac contractility (+/- dp/dt), intracellular high-energy phosphorus compounds, and structural differences. four-week-old vitamin d-deficient chicks were divided into four groups: group a served as the normal group and received subcutaneous injections of cholecalciferol; groups b and c were vitamin d-deficient hearts but perfused differently; group d received daily subcutaneous injections of 5 microg ... | 1989 | 2705637 |
| smoking among medical students in hong kong. | a survey was conducted among two classes of medical students (n = 293) at the university of hong kong to study their smoking habits and knowledge of and attitudes toward smoking. the response rate was 97.3%. there was only one daily smoker (0.4%) and 21 occasional smokers (7.4%). while the respondents regarded health and self-discipline as the main reasons for not smoking, the social taboo against smoking among young people might have also deterred this educated elite from smoking. many of them ... | 1989 | 2700658 |
| [the cold chain: its role and significance in fighting infections controllable by specific prophylactic agents]. | 2009 | 2694697 | |
| [frequent diagnostic errors in diseases with exanthema]. | 2009 | 2690505 | |
| the quantitative relationship of lethality between extracellular protease and extracellular haemolysin of aeromonas salmonicida in atlantic salmon (salmo salar l.). | an additive relationship of lethality between purified protease and haemolysin of the extracellular products (ecp) of aeromonas salmonicida was demonstrated by i.p. injection in atlantic salmon (salmo salar l.). the lethal toxicity of the combinations of protease and haemolysin follow a linear regression line y = -54.54x + 2400. the ld50 of protease and haemolysin when injected separately was 2400 ng/g fish and 44 ng protein/g fish, respectively. | 1989 | 2689276 |
| sodium-transport nadh-quinone reductase of a marine vibrio alginolyticus. | the respiratory chain of a marine bacterium, vibrio alginolyticus, required na+ for maximum activity, and the site of na+ -dependent activation was localized on the nadh-quinone reductase segment. the na+ -dependent nadh-quinone reductase extruded na+ as a direct result of redox reaction. it was composed of three subunits, alpha, beta, and gamma, with apparent mr of 52, 46, and 32 kda, respectively. the reduction of ubiquinone-1 to ubiquinol proceeded via ubisemiquinone radicals. the former reac ... | 1989 | 2687259 |
| induction of partial synchronization of leukemia cells by continuous infusion of low-dose methotrexate followed by citrovorum factor. | 2009 | 2674461 | |
| oviducal storage of spermatozoa in the turkey: its relevance to artificial insemination technology. | 1. this paper addresses questions concerning the role of oviducal sperm selection and storage in the relative inefficiency of turkey reproduction. 2. before the onset of egg production, the turkey has the biological potential to store spermatozoa in its oviduct for periods up to 5 weeks; after the onset of production fewer spermatozoa are retained by the oviduct. 3. a better understanding of the biological mechanisms which regulate sperm selection and storage in the turkey oviduct is necessary t ... | 1989 | 2670069 |