Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| herpes viral cyclin/cdk6 complexes evade inhibition by cdk inhibitor proteins. | the passage of mammalian cells through the restriction point into the s phase of the cell cycle is regulated by the activities of cdk4 and cdk6 complexed with the d-type cyclins and by cyclin e/cdk2. the activities of these holoenzymes are constrained by cdk inhibitory proteins. the importance of the restriction point is illustrated by its deregulation in many tumour cells and upon infection with dna tumour viruses. here we describe the properties of cyclins encoded by two herpesviruses, herpesv ... | 1997 | 9367157 |
| non-hodgkin lymphoma and kaposi sarcoma in an eyelid of a patient with acquired immunodeficiency syndrome. multiple viruses in pathogenesis. | a 36-year-old patient with acquired immunodeficiency syndrome sought care because of an upper eyelid lesion that dramatically increased in size. the histopathologic examination revealed a high-grade diffuse large cell non-hodgkin lymphoma in continuity with a kaposi sarcoma. in situ hybridization revealed epstein-barr virus in the large cell lymphoma and kaposi sarcoma-associated herpesvirus in the kaposi sarcoma lesion. this collision tumor is an unusual presentation of 2 malignant neoplasms in ... | 1997 | 9366682 |
| complete remission of aids-related kaposi's sarcoma associated with undetectable human herpesvirus-8 sequences during anti-hiv protease therapy. | 1997 | 9365774 | |
| follicular dendritic cell sarcoma complicated by hyaline-vascular type castleman's disease in a schizophrenic patient. | follicular dendritic cell (fdc) sarcoma is an exceedingly rare neoplasm of unknown pathogenesis. a case of fdc sarcoma complicated by the hyaline-vascular type castleman's disease occurring in a schizophrenic male is presented. swelling of the left cervical lymph node appeared in a 44-year-old male schizophrenic who had been medicated with major tranquilizers for 20 years. he had had a history of cervical lymphadenopathy 14 years before, for which a diagnosis of hyaline-vascular type castleman's ... | 1997 | 9361105 |
| hiv-associated human herpesvirus 8-positive primary lymphomatous effusions: radiologic findings in six patients. | to define the imaging features of body cavity-based lymphoma (bcbl) related to the acquired immunodeficiency syndrome. this is a peculiar type of non-hodgkin lymphoma harboring infection by human herpesvirus 8 (hhv-8) and displaying a peculiar tropism for the serous body cavities. | 1997 | 9356629 |
| absence of human herpesvirus 8 dna in benign and malignant endothelial lesions. | 1997 | 9350784 | |
| human herpesvirus 8 dna sequences in angiosarcoma of the face. | 1997 | 9349352 | |
| ultrastructural characterization of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus) in kaposi's sarcoma lesions: electron microscopy permits distinction from cytomegalovirus (cmv). | kaposi's sarcoma (ks) has been shown by molecular techniques to be associated with infection with human herpesvirus 8 (hhv8/kshv), but specific ultrastructural characterization of the virus has been impaired by the frequent presence in these lesions of other herpesviruses, particularly cytomegalovirus (cmv). since the ultrastructural appearance of hhv8/kshv has been studied in the cell line ks-1 uninfected with other viruses including cmv, it was possible to undertake a comparative study of cmv ... | 1997 | 9349229 |
| kaposi's sarcoma-associated herpesvirus (kshv)/human herpesvirus 8 (hhv8)--a new human tumour virus. | recently, a novel dna virus has been molecularly cloned from kaposi's sarcoma (ks) tissue, a tumour common in acquired immune deficiency syndrome (aids). analysis of the viral genome confirms that it is a relative of human herpesviruses and the virus has been designated hhv-8. epidemiological evidence suggests a strong aetiological link between the presence of hhv-8 dna and/or antibodies against the virus, and ks. additional sequence analysis suggests that the hhv-8 genome contains sequences whi ... | 1997 | 9349227 |
| resolution of kaposi's sarcoma associated with undetectable level of human herpesvirus 8 dna in a patient with aids after protease inhibitor therapy. | 1997 | 9344209 | |
| lack of serologic evidence for involvement of human herpesvirus 8 in autoimmune diseases. | 1997 | 9336431 | |
| hhv-8 in pbmc and kaposi's sarcoma activity. | 1997 | 9334874 | |
| occurrence of human herpes virus 8 in kaposi's sarcoma and other tumours in south africa. | 1997 | 9323419 | |
| herpesvirus-like dna sequences in kaposi's sarcoma lesions from two women with aids. | 1997 | 9314474 | |
| malignant tumors and aids. | one in six patients with acquired immunodeficiency syndrome (aids) both in the usa and europe develop malignancies, in particular kaposi's sarcoma (ks) and non-hodgkin's lymphoma (nhl). after an initial rapid increase, the proportion of aids patients with ks steadily declined in the usa and in europe, while the proportion of aids-nhl has been stable during the last decade in the usa and europe. human immunodeficiency virus (hiv) infected patients are living longer due to advances in antiretrovir ... | 1997 | 9309244 |
| primary plasmacytoma of lymph nodes. | primary plasmacytoma of the lymph nodes is very rare, and there are fewer than 20 reported cases. these cases appeared to have a better prognosis than other extramedullary plasmacytomas, with rare recurrence and no progression to myeloma after treatment. to better characterize the clinicopathological features and the pathogenesis of primary plasmacytoma of the lymph nodes, we reviewed our consultation files and retrieved seven such cases. the age of presentation ranged from 39 to 76 years (media ... | 1997 | 9308734 |
| aids-related kaposi's sarcoma: prospective validation of the aids clinical trials group staging classification. aids clinical trials group oncology committee. | to prospectively validate the aids clinical trials group (actg) staging classification for aids-associated kaposi's sarcoma (ks). | 1997 | 9294471 |
| prevalence of human herpesvirus-8 in skin lesions. | a putative new herpesvirus, designated kaposi's sarcoma-associated herpesvirus (kshv) or human herpesvirus-8 (hhv-8) was recently identified in aids-related kaposi's sarcoma. the dna sequence of the virus is homologous to the gamma-herpesviruses such as herpesvirus saimiri or epstein-barr virus, both of which are tumorigenic, suggesting that this new virus may also be oncogenic. thus, we determined whether the virus is present in other skin lesions. dna samples from 118 skin specimens were teste ... | 1997 | 9292063 |
| high-dose interferon-alpha2a exerts potent activity against human immunodeficiency virus type 1 not associated with antitumor activity in subjects with kaposi's sarcoma. | anti-human immunodeficiency virus type 1 (hiv-1) activity was assessed in hiv-1-infected homosexual and bisexual men receiving 18-36 miu/day of recombinant interferon (ifn)-alpha2a for kaposi's sarcoma (ks). the median baseline hiv-1 rna level was 4.99 log10 copies/ml. seventeen subjects (68%) showed an rna decline > or = .5 log10/ml, with a maximum at week 4 (median decline = 1.91, range = 3.64-1.15; p = .0007), after which rna levels stabilized. eight subjects (32%) with lower median initial c ... | 1997 | 9291341 |
| [human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus]. | 1997 | 9290315 | |
| kaposi's sarcoma as manifestation of immunosuppression in organ transplant recipients. | we report 2 patients, negative for human immunodeficiency virus (hiv) antibodies, who developed generalized kaposi's sarcoma (ks), one 5 months after renal transplantation while receiving cyclosporin a and prednisone, and the other 24 months after heart transplantation while receiving cyclosporin a, azathioprine and prednisone. reduction of the immunosuppressive therapy combined with chemotherapy and radiotherapy in both cases led to a remission of ks without development of transplant rejection. | 1997 | 9267755 |
| kaposi's sarcoma-associated herpesvirus sequences in benign lymphoid proliferations not associated with human immunodeficiency virus. | kaposi's sarcoma-associated herpesvirus (kshv) dna sequences have been identified in approximately 95% of kaposi's sarcoma (ks) lesions and primary effusion lymphomas (pels), suggesting a pathogenetic role for this virus in these lesions. however, kshv has also been identified in a variety of specimens, including lymph nodes, peripheral blood b cells, semen, and prostate tissue, with varying frequencies. this suggests that kshv, like epstein-barr virus, may be ubiquitously distributed. to evalua ... | 1997 | 9264363 |
| epstein-barr virus latent gene expression in primary effusion lymphomas containing kaposi's sarcoma-associated herpesvirus/human herpesvirus-8. | primary effusion (body cavity-based) lymphoma (pel) is a recently recognized subtype of malignant lymphoma that exhibits distinctive clinical and biological features, most notably its usual infection with the kaposi's sarcoma-associated herpesvirus (kshv). the vast majority of cases also contain epstein-barr virus (ebv). this dual viral infection is the first example of a consistent dual herpesviral infection in a human neoplasm and provides a unique model to study viral interactions. we analyze ... | 1997 | 9242551 |
| sequences of human herpesvirus 8 are not detected in various non-kaposi sarcoma vascular lesions. | 1997 | 9236539 | |
| a kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vil-6) activates signaling through the shared gp130 receptor subunit. | the present studies analyzed the biologic activity of a gene product (vil-6) encoded by the recently discovered kaposi's sarcoma-associated herpesvirus (kshv) bearing 24.8% amino acid identity with human interleukin-6 (huil-6). based on this similarity, we hypothesized that this viral homolog might trigger the jak/stat pathway, which typically is engaged by il-6 and other cytokines. activation of receptor-associated janus tyrosine kinases (jaks) results in the subsequent phosphorylation of signa ... | 1997 | 9235971 |
| kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 encephalitis in hiv-positive and -negative individuals. | kaposi's sarcoma-associated herpesvirus (kshv) human herpesvirus type 8 (hhv-8) has been associated with kaposi's sarcoma and a variety of benign lymphoid proliferations including angioimmunoblastic lymphadenitis with dysproteinemia and castleman's disease. kshv/hhv-8 has also been associated with inflammatory conditions including interstitial pneumonitis. although herpesviruses are commonly associated with encephalitis in immunosuppressed individuals, kshv/hhv-8 has not previously been associat ... | 1997 | 9233458 |
| simultaneous onset of primary cutaneous b-cell lymphoma and human herpesvirus 8-associated kaposi's sarcoma. | we report the simultaneous occurrence of kaposi's sarcoma (ks) and primary cutaneous b-cell lymphoma (cbcl) of the leg in a 79-year-old woman, seronegative for hiv-1, htlv-1 and htlv-2. the cbcl underwent complete clinical remission after local radiotherapy, whilst the ks became disseminated within a year following diagnosis. however, 2 years after the diagnosis of ks, the patient died with neurological symptoms. these were presumed to be due to involvement of the central nervous system by lymph ... | 1997 | 9217827 |
| kaposi's sarcoma-associated herpesvirus/human herpesvirus-8: a new virus in human pathology. | the discovery of a new human herpesvirus in kaposi's sarcoma (ks) tissue of patients with aids has opened up new vistas in virology and oncology. this herpesvirus was first descriptively named ks-associated herpesvirus (kshv), but was recently renamed human herpesvirus 8 (hhv8). kshv/hhv8 dna has been found in all forms of ks, suggesting that it might be involved in the pathogenesis of ks. in addition, kshv/hhv8 can be detected in both malignant and benign lymphoproliferative disease. kshv/hhv8 ... | 1997 | 9216532 |
| herpes virus (kshv) associated kaposi sarcoma in a 3-year-old child with non-hiv-induced immunodeficiency. | a 3-year-old boy of german descent suffered from two episodes of streptococcus pneumoniae meningitis within 2 months. one month previously, the first skin lesion of kaposi sarcoma (ks) had been observed behind his right ear. during the following 2 years ks disseminated not only mucocutaneously but also to visceral organs. immunological evaluation revealed severe lymphocytopenia with reduced helper/suppressor t-cell ratio and impaired humoral immune response to pneumococci. extensive laboratory t ... | 1997 | 9208237 |
| [a new gamma-2 herpesvirus, defined as hhv8 or kaposi's sarcoma herpes virus (kshv), could be involved in the pathogenesis of kaposi's sarcoma]. | 1996 | 9206783 | |
| interleukin-4 receptor expression on aids-associated kaposi's sarcoma cells and their targeting by a chimeric protein comprised of circularly permuted interleukin-4 and pseudomonas exotoxin. | aids-associated kaposi's sarcoma (aids-ks) represents one of the most common malignancies associated with human immunodeficiency virus infection. to target effective therapeutic agents to aids-ks, we have identified a new target in the form of interleukin-4 receptors (il-4r). | 1997 | 9205948 |
| propagation of a human herpesvirus from aids-associated kaposi's sarcoma. | 1997 | 9190501 | |
| kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. | kaposi's sarcoma-associated herpesvirus (kshv) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. in addition the virus was detected in the bone marrow dendritic cells from two out of eight patients with monoclonal gammopathy of undetermined significance (mgus), a precursor to myeloma. viral interleukin-6, the human homolog of which is a growth fact ... | 1997 | 9188529 |
| no evidence of kshv/hhv-8 in mycosis fungoides or associated disorders. | the recently discovered human virus known as kaposi's sarcoma-associated herpesvirus (kshv) or human herpesvirus-8 (hhv-8) has been associated with body-cavity-based lymphomas in aids patients. it is most closely related to two other herpesviruses, the epstein-barr virus and herpesvirus saimiri, which are known to be associated with lymphomas in humans and nonhuman primates, respectively. to determine whether kshv/hhv-8 is involved in the pathogenesis of mycosis fungoides (mf) and related disord ... | 1997 | 9182822 |
| detection of human herpes virus 8 dna and sequence polymorphism in classical, epidemic, and iatrogenic kaposi's sarcoma in south africa. | the aetiology and detection of human herpes virus type 8 (hhv-8) dna sequences in kaposi's sarcoma (ks) is a matter of intense investigation. we report on the detection of hhv-8 dna and sequence polymorphism in different clinicopathological subtypes of cutaneous ks samples from south africa. the diagnosis was confirmed by histological examination in all cases. six patients had classic ks (cks), 3 epidemic ks (eks), and 3 iatrogenic ks (iks). a nested polymerase chain reaction (pcr) assay was use ... | 1997 | 9179764 |
| hiv-1 tat induces the expression of the interleukin-6 (il6) gene by binding to the il6 leader rna and by interacting with caat enhancer-binding protein beta (nf-il6) transcription factors. | human immunodeficiency virus type 1 (hiv-1) infection is associated with severe psoriasis, b cell lymphoma, and kaposi's sarcoma. a deregulated production of interleukin-6 (il6) has been implicated in the pathogenesis of these diseases. the molecular mechanisms underlying the abnormal il6 secretion of hiv-1-infected cells may include transactivation of the il6 gene by hiv-1. here we report the molecular mechanisms of tat activity on the expression of the il6 gene. by using 5' deletion mutants of ... | 1997 | 9169458 |
| utility of fine needle aspiration in hiv-positive patients with corresponding cd4 counts. four years' experience in a large inner city hospital. | to assess the utility of fine needle aspiration (fna) in human immunodeficiency virus (hiv)-positive patients with corresponding cd4 count analysis. | 1997 | 9167706 |
| human herpesvirus 8 in kaposi's sarcoma of an hiv-negative japanese woman with adult t-cell leukemia. | 1997 | 9163629 | |
| hhv-8 and aids-related cns lymphoma. | human herpesvirus 8 (hhv-8), the kaposi's sarcoma (ks)-associated herpesvirus, is closely related to the transforming epstein-barr virus (ebv) and may be detected in aids-related, ebv-containing, body-cavity-based lymphomas. accordingly, we analyzed 27 ebv-positive, aids-related cns lymphomas for hhv-8 sequences. only one tumor yielded hhv-8 sequences; this tumor arose in a patient with concomitant systemic lymphoma and a history of ks. we conclude that hhv-8 is unlikely to have a major role in ... | 1997 | 9153468 |
| cell-homologous genes in the kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity? | 1997 | 9151804 | |
| does hiv tat protein also regulate genes of other viruses present in hiv infection? | 1997 | 9149528 | |
| exacerbations of clinical symptoms in human immunodeficiency virus type 1-infected patients with multicentric castleman's disease are associated with a high increase in kaposi's sarcoma herpesvirus dna load in peripheral blood mononuclear cells. | the epidemiologic link between multicentric castleman's disease (mcd) and kaposi's sarcoma (ks) and the high frequency of ks herpesvirus (kshv) detection in both diseases raise the question of a role of this new virus in the pathogenesis of mcd. to explore this hypothesis, the kshv dna load was investigated in peripheral blood mononuclear cells of 3 human immunodeficiency virus (hiv)-infected patients with mcd at different points during the clinical course. clinical parameters, such as fever and ... | 1997 | 9129085 |
| detection of serum antibodies to a kaposi's sarcoma-associated herpesvirus-specific peptide. | kaposi's sarcoma (ks)-associated herpesvirus/human herpesvirus type 8 (kshv/hhv-8) may play an etiologic role in the pathogenesis of ks. in an attempt to assess kshv/hhv-8 infection, an elisa was developed using an 18-amino acid peptide from a putative minor capsid protein of kshv/hhv-8 conjugated to bovine serum albumin. overall, sera from human immunodeficiency virus type 1 (hiv-1)-positive patients with ks had a higher reactivity in the assay than did sera from hiv-1-positive patients without ... | 1997 | 9129068 |
| kaposi's sarcoma and its management in aids patients. recommendations from a scandinavian study group. | ks is the most frequent malignancy in homo/bisexual male aids patients, affecting more than 30% of these patients. ks may present itself as a few innocent cutaneous lesions or may show progression resulting in severe morbidity and mortality. approximately half of the patients may develop severe progressive disease. the prognosis of patients with progressive disease is poor, with a median survival of less than 6 months. there is no cure for aids-related ks, but several therapies are available for ... | 1997 | 9112290 |
| corrected prevalence of kaposi's sarcoma (ks)-associated herpesvirus infection prior to onset of ks. | 1997 | 9110091 | |
| kaposi's sarcoma and sex hormones. | 1997 | 9108954 | |
| [pulmonary kaposi's sarcoma in a patient with the acquired immunodeficiency syndrome]. | cutaneous kaposi's sarcoma (ks) is a well-known manifestation of the acquired immunodeficiency syndrome, but pulmonary ks is very rare in japan. we encountered a 27-year-old japanese, homosexual man who had extensive pulmonary ks. he came to our hospital because of a cough and dyspnea. on admission, there were some small nodules on the skin, and examination of a biopsy specimen led to the diagnosis of ks. the test for the human immunodeficiency virus antibody was positive and the cd4+ cell count ... | 1997 | 9103865 |
| high incidence of kaposi's sarcoma-associated herpesvirus and epstein-barr virus in tumor lesions and peripheral blood mononuclear cells from patients with kaposi's sarcoma in uganda. | with the advent of aids, kaposi's sarcoma (ks) has become one of the leading malignancies in sub-saharan africa. recently, dna sequences from a new human herpesvirus called ks-associated herpesvirus (kshv) or human herpesvirus type 8 have been found in ks tumor lesions in high frequency. analyses of tumor lesions from 38 ugandan ks patients indicated a uniform presence of kshv in ks tumor lesions as revealed by polymerase chain reaction and southern hybridization. in contrast, only 31% (11/36) o ... | 1997 | 9086156 |
| progressive loss of cd8+ t cell-mediated control of a gamma-herpesvirus in the absence of cd4+ t cells. | a unique experimental model has been developed for dissecting the integrity of cd8+ t cell-mediated immunity to a persistent gammaherpesvirus under conditions of cd4+ t cell deficiency. respiratory challenge of major histocompatibility complex class ii -/- and +/+ c57bl/6j mice with the murine gammaherpesvirus 68 (mhv-68) leads to productive infection of both lung and adrenal epithelial cells. virus titers peak within 5-10 d, and are no longer detected after day 15. persistent, latent infection ... | 1996 | 9064346 |
| kaposi's sarcoma-associated herpesvirus: a lymphotropic human herpesvirus associated with kaposi's sarcoma, primary effusion lymphoma, and multicentric castleman's disease. | despite extensive epidemiological evidence suggesting that kaposi's sarcoma (ks) has an infectious origin, a specific viral association with ks had not been documented until recently, when two novel dna fragments were identified in ks lesional tissue from a patient with the acquired immunodeficiency syndrome (aids). these fragments belong to a previously unidentified human herpesvirus, called ks-associated herpesvirus (kshv), or human herpesvirus 8. although this virus is generally absent from n ... | 1997 | 9044510 |
| kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. | kaposi's sarcoma-associated herpesvirus (kshv) (also called human herpesvirus 8) is consistently found in kaposi's sarcoma lesions and in body-cavity-based lymphomas. a 17-kb kshv lambda clone was obtained directly from a kaposi's sarcoma lesion. dna sequence analysis of this clone identified an open reading frame which has 32% amino acid identity and 53% similarity to the virus-encoded cyclin (v-cyclin) of herpesvirus saimiri (hvs) and 31% identity and 53% similarity to human cellular cyclin d2 ... | 1997 | 9032330 |
| a single 13-kilobase divergent locus in the kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins. | two small fragments of a novel human gammaherpesvirus genome known as kaposi's sarcoma (ks)-associated herpesvirus or human herpesvirus 8 (hhv-8) have been shown to be present in virtually all aids and non-aids ks lesions, as well as in body cavity-based lymphomas (bcbl) and in multicentric castleman's disease. we have extended those studies by identifying and sequencing a third fragment of hhv-8 dna encoding a viral thymidylate synthetase (ts) gene. use of this viral ts fragment as a probe led ... | 1997 | 9032328 |
| circulating spindle cells: correlation with human herpesvirus-8 (hhv-8) infection and kaposi's sarcoma. | 1997 | 9014921 | |
| a bcl-2 homolog encoded by kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with bax or bak. | the bcl-2 protein family is characterized by the ability to modulate cell death, and members of this family share two highly conserved domains called bcl-2 homology 1 (bh1) and 2 (bh2) which have been shown to be critical for the death-repressor activity of bcl-2 and bcl-xl. through sequence analysis we identified a novel viral bcl-2 homolog, designated ksbcl-2, from human herpesvirus 8 (hhv8) or kaposi sarcoma-associated herpesvirus. the overall amino acid sequence identity between ksbcl-2 and ... | 1997 | 9012846 |
| kaposi sarcoma-associated herpesvirus/human herpesvirus type 8 and epstein-barr virus in iatrogenic kaposi sarcoma. | 1997 | 9006388 | |
| kaposi sarcoma, kaposi sarcoma-associated herpesvirus, and human t-cell lymphotropic virus type 1. what is the current evidence for causality? | 1997 | 9006376 | |
| detection of the herpesvirus-like dna sequences in matched specimens of semen and blood from patients with aids-related kaposi's sarcoma by polymerase chain reaction in situ hybridization. | the dna sequences of a novel human gamma-herpesvirus type 8 (hhv-8) have recently been detected in kaposi's sarcoma (ks) lesions obtained from different populations in whom this neoplasm occurs, suggesting that this virus may be implicated in the etiology and/or pathogenesis of ks. to study the distribution and possible means of transmission of the putative viral agent, specimens of ks skin lesions, matched uninvolved skin, peripheral blood mononuclear cells (pb-mcs), and semen were collected fr ... | 1997 | 9006331 |
| detection of hhv-8 in sjögren's syndrome. | 1996 | 9003115 | |
| pirated genes in kaposi's sarcoma. | 1997 | 9002510 | |
| characterization of ribonucleoprotein complexes containing an abundant polyadenylated nuclear rna encoded by kaposi's sarcoma-associated herpesvirus (human herpesvirus 8). | infection with kaposi's sarcoma-associated herpesvirus (kshv) (also called human herpesvirus 8) is strongly linked to all forms of kaposi's sarcoma. we have previously identified two polyadenylated kshv transcripts that are actively transcribed in kaposi's sarcoma (ks) tumors and in kshv-infected b-lymphoma cells. one of these rnas (termed t1.1 or nut-1 rna) is a 1.1-kb transcript present in a subpopulation of ks tumor cells. this rna is localized to the nucleus of infected cells and has no open ... | 1997 | 8995643 |
| oral manifestations associated with human immunodeficiency virus infection in a spanish population. | a study was made of the oral manifestations in 396 patients with human immunodeficiency virus (hiv) infection. the following risk groups were established: intravenous drug users (79.5%), homosexuals (7.8%), homosexual intravenous drug users (3.3%), heterosexuals (8.1%) and hemophiliacs/transfusion patients (1.3%). the oral lesions, in decreasing order of frequency, were: periodontal disease (78.28%), candidiasis (65.65%), hairy leukoplakia (16.16%), herpes simplex virus lesions (5.30%). kaposi's ... | 1996 | 8986962 |
| kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. | the recent discovery of dna sequences of a new human herpesvirus in kaposi's sarcoma (ks) has fueled speculation that this virus might cause ks. the mere presence, however, of a virus in a complex multicellular tumor like ks could just as well be construed as evidence of a passenger agent. we sought stronger evidence linking the ks-associated herpesvirus (kshv) to tumor formation by using in situ hybridization to investigate the specificity, constancy, and timing of kshv gene expression in ks tu ... | 1997 | 8985403 |
| selective switch between latency and lytic replication of kaposi's sarcoma herpesvirus and epstein-barr virus in dually infected body cavity lymphoma cells. | the bc-1 cell line, derived from a body cavity-based, b-cell lymphoma, is dually infected with epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv). in these studies, the relationships between these two gammaherpesviruses and bc-1 cells were characterized and compared. single-cell cloning experiments suggested that all bc-1 cells contain both genomes. in more than 98% of cells, both viruses were latent. the two viruses could be differentially induced into their lytic cycle ... | 1997 | 8985352 |
| absence of kaposi's sarcoma-associated herpesvirus-like dna sequences in malignant vascular tumors of the serous membranes. | reports connect kaposi's sarcoma-associated herpesvirus (kshv) with various types of kaposi's sarcoma (ks) and body-cavity-based lymphomas (primary effusion lymphomas). kshv dna sequences have also been detected in a few non-ks malignant vascular tumors. to determine whether kshv is associated with malignant vascular tumors involving the body cavities, 11 primary vascular tumors of the serous membranes (4 angiosarcomas, 7 hemangioendotheliomas) were tested for kshv sequences by polymerase chain ... | 1996 | 8972473 |
| hiv-1 and kaposi's sarcoma. | 1996 | 8972281 | |
| absence of herpesvirus in aids-associated smooth-muscle tumors. | 1996 | 8965873 | |
| hhv-8 serology and kaposi's sarcoma. | 1996 | 8950901 | |
| kaposi's sarcoma and hhv-8. | 1996 | 8950809 | |
| kaposi's sarcoma: evaluation of the role of human papillomaviruses. a study using the high sensitivity hot-start polymerase chain reaction detection method and a review of the literature. | 1996 | 8950462 | |
| the sex ratio of aids-associated kaposi's sarcoma does not provide evidence that sex hormones play a role in pathogenesis. | 1996 | 8931798 | |
| kaposi's sarcoma-associated herpesvirus in kaposi's sarcoma occurring in immunosuppressed renal transplant recipients. | kaposi's sarcoma-associated herpesvirus (kshv) has been implicated in the genesis of kaposi's sarcoma and other tumors occurring in immunosuppressed individuals. using amplification by the polymerase chain reaction and nucleotide sequencing of extracted dna, we have detected the ks330(233) sequence of kshv dna in kaposi's sarcoma tissue from 4 immunosuppressed renal transplant recipients. the sequences shared a greater than 98% homology with those described in kshv dna from kaposi's sarcoma in p ... | 1996 | 8930456 |
| multicentric castleman's disease in hiv infection: a clinical and pathological study of 20 patients. | to describe, in a retrospective study, the clinical and pathological spectrum of multicentric castleman's disease (mcd) in hiv infection. | 1996 | 8924253 |
| increases in cd3+cd4-cd8- t lymphocytes in aids patients with disseminated mycobacterium avium-intracellulare complex infection. | human immunodeficiency virus type 1 (hiv-1)-infected persons frequently have increased numbers of t cells bearing the gamma delta t cell receptor for antigen (gamma delta tcr). hiv-1-seropositive patients with < 100 cd4+ cells/mm3 were selected and divided into 9 aids-defining illness groups. the percentages of cd4+, cd8+, or double-negative cd4-cd8- (dn) t cells (most of the latter expressing the gamma delta tcr) for 8 symptomatic groups were compared with those for a reference group of asympto ... | 1996 | 8896497 |
| changing seroepidemiology of hhv-8. | 1996 | 8888158 | |
| kaposi's sarcoma: relationship to a novel herpesvirus and advances in therapy. | 1996 | 8883626 | |
| spindle cells isolated from kaposi's sarcoma-like lesions of bkv/tat-transgenic mice co-express markers of different cell types. | to characterize murine spindle cells isolated from kaposi's sarcoma-like skin lesions developed in bk virus (bkv)/tat-transgenic mice. | 1996 | 8883582 |
| detection of herpesvirus-like dna by nested pcr on archival skin biopsy specimens of various forms of kaposi sarcoma. | to detect herpesvirus-like dna sequences, defining a new herpesvirus, human herpesvirus 8 (hhv8), in paraffin wax embedded skin biopsy specimens of the various forms of kaposi sarcoma. | 1996 | 8881911 |
| oncological problems in aids--a review of the clinical features and management. | since the beginning of the acquired immunodeficiency syndrome (aids) epidemic in the early 1980s, several malignant conditions have been recognised to be associated with this syndrome which affect up to 40% of aids patients at some stage of their illness. they include kaposi's sarcoma, systemic non-hodgkin's lymphoma, primary central nervous system lymphoma and invasive cervical cancer. kaposi's sarcoma and primary central nervous system lymphoma were tumours rarely seen below the age of 50 prio ... | 1996 | 8876905 |
| human immunodeficiency virus infection and acquired immunodeficiency syndrome among north american women. | women constitute the fastest growing segment of adults with acquired immunodeficiency syndrome (aids), representing 18% of all cases in the united states in 1994. heterosexual transmission is now the dominant route by which women are infected. recent reports indicate that although certain manifestations may be different in women than in men, the rate of clinical progression is similar when they receive comparable medical treatment. antiretroviral therapy is equally as effective in women as in me ... | 1996 | 8873494 |
| detection of herpesvirus-like dna in the bronchoalveolar lavage fluid of patients with pulmonary kaposi's sarcoma. | pulmonary involvement is a clinically important form of visceral kaposi's sarcoma in immunocompromised patients. recently, herpesvirus-like deoxyribonucleic acid (dna) sequences, defining a new herpesvirus termed "human herpesvirus 8" (hhv8) or "kaposi's sarcoma-associated herpesvirus" (kshv), were detected in kaposi's sarcoma of acquired immune deficiency syndrome (aids) and non-aids patients. we describe the successful detection of hhv8 dna in the bronchoalveolar lavage (bal) fluid of patients ... | 1996 | 8866603 |
| establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (bc-3) harboring kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) in the absence of epstein-barr virus. | the recently identified kaposi's sarcoma-associated herpesvirus (kshv), also known as human herpesvirus 8 (hhv-8), has been found to be consistently associated with an unusual subset of acquired immunodeficiency syndrome-related lymphomas, the so-called body cavity-based lymphomas (bcbl) or primary effusion lymphomas (pel). these lymphomas are characterized by a unique spectrum of morphologic and molecular characteristics, and grow as lymphomatous effusions without an identifiable contiguous tum ... | 1996 | 8839859 |
| kaposi's sarcoma-associated herpesvirus infection prior to onset of kaposi's sarcoma. | kaposi's sarcoma-associated herpesvirus (kshv), a newly discovered human gammaherpesvirus, is found in the majority of ks lesions from patients with and without aids. peripheral blood mononuclear cells (pbmc) were examined for kshv dna to determine whether viral infection precedes onset of this neoplasm. | 1996 | 8838705 |
| antibodies to human herpesvirus type 8 in the general population and in kaposi's sarcoma patients. | much of the evidence that human herpesvirus type 8 (hhv-8) is associated with kaposi's sarcoma (ks) has come from molecular studies of hhv-8 dna. seroepidemiological studies have been hampered by the lack of a reliable assay. | 1996 | 8826812 |
| the lung in hiv infection: can pulmonary function testing help? | simple lung function tests have been used to evaluate respiratory symptoms in human immunodeficiency virus (hiv) infected individuals. abnormalities of simple lung function tests, in particular decreases in the transfer factor of the lung for carbon monoxide (tl,co) have been described in patients with acquired immune deficiency syndrome (aids) who have respiratory disease. early studies showed marked reductions in tl,co in patients with pneumocystis pneumonia but other forms of pulmonary infect ... | 1996 | 8766197 |
| acute myelocytic leukaemia associated with kaposi's sarcoma in a patient without serum antibodies to human immunodeficiency virus type 1. | we report a 35-year-old man with acute myelocytic leukaemia and kaposi's sarcoma, whose serum was non-reactive for antibodies to human immunodeficiency virus type-1 by enzyme-linked immunosorbent assay, western blot and immunofluorescence. complete remission of both the acute leukaemia and the kaposi's sarcoma followed treatment with mitoxantrone and cytosine arabinoside. we speculate that the rapid regression of the lesions of kaposi's sarcoma might be related to mitoxantrone and to the return ... | 1996 | 8731687 |
| human herpesvirus-8 in aids-related and unrelated lymphomas. | 1996 | 8724048 | |
| the seroepidemiology of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus): distribution of infection in ks risk groups and evidence for sexual transmission. | striking differences in kaposi's sarcoma (ks) risk for aids patients who acquire hiv via homosexual activity and those whose hiv infections derive from blood product exposure suggest the presence of a sexually transmitted agent other than hiv in the development of ks. using an immunofluorescence assay, we examined serum samples from 913 patients for the presence of antibody specific for infection by human herpesvirus 8 (hhv8), an agent whose genome is regularly found in ks tissue. the distributi ... | 1996 | 8705863 |
| kaposi's sarcoma (ks)-associated herpesvirus-like dna sequences in peripheral blood mononuclear cells: association with ks and persistence in patients receiving anti-herpesvirus drugs. | herpesvirus-like dna sequences (kshv/hhv-8) have recently been described in aids-associated kaposi's sarcoma (ks) lesions. many questions remain regarding the role of this virus in ks and the therapeutic implications of this finding. in the current study, kshv/hhv-8 dna was detected in peripheral blood mononuclear cells (pbmcs) from human immunodeficiency virus (hiv)-infected patients with ks (34/98) more often than in hiv-infected individuals without ks (12/64, p = .03). the detection of kshv/h ... | 1996 | 8704186 |
| primary effusion lymphoma: a distinct clinicopathologic entity associated with the kaposi's sarcoma-associated herpes virus. | we recently discovered the kaposi's sarcoma-associated herpes virus (kshv/hhv-8) in an uncommon and unusual subset of aids-related lymphomas that grow mainly in the body cavities as lymphomatous effusions without an identifiable contiguous tumor mass. the consistent presence of kshv and certain other distinctive features of these body cavity-based lymphomas suggest that they represent a distinct entity. we tested this hypothesis by investigating 19 malignant lymphomatous effusions occurring in t ... | 1996 | 8695812 |
| kaposi's sarcoma-associated herpesvirus in non-aids related lymphomas occurring in body cavities. | dna sequences belonging to the recently discovered kaposi's sarcoma-associated herpesvirus (kshv), now provisionally designated human herpesvirus 8, have been previously identified in an uncommonly occurring subset of aids-related lymphomas, referred to as body-cavity-based lymphomas (bcbls), which present as lymphomatous effusions. pyothorax-associated lymphomas (pals) are non-hodgkin's lymphomas that arise in the pleural cavity after long-standing pleural inflammation resulting from therapeuti ... | 1996 | 8686762 |
| aids-related conditions: study of a representative sample of 1203 patients deceased in 1992 in france. | little representative information exists on the frequency of human immunodeficiency virus (hiv)-related diseases among the overall aids population. the objective of this research is to assess the nature, frequency and characteristics of these diseases among aids patients during their last year of life and to analyse these frequencies according to the mode of transmission and other socio-demographic and medical characteristics. | 1996 | 8666489 |
| [differential radiologic diagnosis of hiv-associated lung diseases]. | in 1993 in germany an estimated number of 50,000-70,000 individuals were infected with the human immunodeficiency virus (hiv), who estimations ranged up to 14 million hiv-positive individuals including 1 million children. aids-related diseases frequently occur in the lung. 65% of all aids-defining illnesses begin with life-threatening pulmonary infections. most frequently hiv-positive patients present with pneumocystis carinii pneumonia, followed by atypical mycobacteriosis, bacterial infections ... | 1995 | 8653002 |
| use of antiherpes drugs and the risk of kaposi's sarcoma: data from the multicenter aids cohort study. | to determine if use of antiherpes drugs protects against the development of aids-associated kaposi's sarcoma (ks), data from 935 homosexual men with aids from the multicenter aids cohort study were analyzed. in nested case-control analysis, neither acyclovir use for human immunodeficiency virus infection (odds ratio [or], 0.84; 95% confidence interval [ci], 0.56-1.26; p = .39) nor acyclovir use for any indication (or, 1.02; 95% ci, 0.76-1.38; p = .89) was associated with a reduced risk of ks as ... | 1996 | 8648224 |
| human herpesvirus-8/kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects b cells. | herpesviral dna fragments isolated from aids-associated kaposi's sarcoma (ks) tissue (kshv-dna) share homology with two lymphotropic oncogenic gamma-herpesviruses, epstein-barr virus and herpesvirus saimiri, and are present in the lesions of more than 95% of hiv and non-hiv-associated forms of ks, aids-related body cavity-based lymphomas, and aids-related multicentric castleman's disease. here we show that bc-1, a kshv-dna-positive, body cavity-based lymphoma cell line, produces infective herpes ... | 1996 | 8642350 |
| herpesvirus-like dna sequences and kaposi's sarcoma: relationship with epidemiology, clinical spectrum, and histologic features. | the evidence of an infectious agent other than human immunodeficiency virus (hiv) acting as a possible etiologic cause of kaposi's sarcoma (ks) has received considerable attention in the last years. recently, dna sequences from a new herpesvirus (hhv-8) have been observed in several cases of ks. the discovery suggests that this virus may play a role in the pathogenesis of ks. to evaluate these results, we determined the frequency of hhv-8 dna sequences in 78 specimens of ks according to differen ... | 1996 | 8640682 |
| combination chemotherapy with doxorubicin, bleomycin, and vindesine for aids-related kaposi's sarcoma. | kaposi's sarcoma is the most common neoplasm in patients with human immunodeficiency virus (hiv) infection. although the best therapeutic approach is still unclear, patients with advanced ks are usually treated with systemic chemotherapy. | 1996 | 8640679 |
| frequency and distribution of herpesvirus-like dna sequences (kshv) in different stages of classic kaposi's sarcoma and in normal tissues from an italian population. | the frequency and distribution of herpesvirus-like dna sequences (kshv) were investigated by pcr in the pathologic skin lesions of a series of 22 hiv-negative elderly patients with classic kaposi's sarcoma (ks) from italy, one of the few regions of the world where classic ks is prevalent. viral sequences were clearly identifiable in 15 cases, in particular in 2 of 5 patch, in 3 of 6 plaque and in 10 of 11 nodular lesions. our findings confirm the association of these herpesvirus-like dna sequenc ... | 1996 | 8635855 |
| cutaneous cryptococcus infection and aids. report of 12 cases and review of the literature. | cryptococcal infections occur in 6% to 13% of patients with acquired immunodeficiency syndrome (aids), most commonly infecting the central nervous system. cutaneous lesions have been described morphologically as umbilicated papules, nodules, and violaceous plaques and can mimic molluscum contagiosum and kaposi's sarcoma. cutaneous lesions can present months prior to other signs of systemic infection. | 1996 | 8624151 |
| human herpesvirus-8 dna sequences in human immunodeficiency virus-negative angioimmunoblastic lymphadenopathy and benign lymphadenopathy with giant germinal center hyperplasia and increased vascularity. | human herpesvirus-8 (hhv-8) dna sequences have been reported to be strictly associated not only with various forms of kaposi's sarcoma but also with an unusual subgroup of acquired immunodeficiency syndrome (aids)-related b-cell lymphomas. a possible relation of this putative virus also with multicentric castleman's disease (mcd) has been recently suggested. we used polymerase chain reaction to look for the presence of hhv-8 sequences in a well characterized series of benign, atypical, and malig ... | 1996 | 8611719 |
| [kaposi's sarcoma in dermatology consultations at lome, togo]. | the purpose of this retrospective study conducted in a dermatologic out patient clinic in lomé was to assess the epidemiologic, clinical, and prognostic profile of kaposi's sarcoma in togo during the 15 years period between 1980 and 1994. only patients who had undergone serologic tests for human immunodeficiency virus (hiv) were included. there were 30 patients (27 men and 3 women) with a mean age of 35.2 years (range: 17 to 59 years). thirteen patients were seropositive (epidemic kaposi's sarco ... | 1995 | 8559021 |