Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| epstein-barr virus is associated with periodontal diseases: a meta-analysis based on 21 case-control studies. | some controversies still exist between the detection of epstein-barr virus (ebv)'s dna and risks of periodontal diseases. hence, a comprehensive meta-analysis on all available literatures was performed to clarify the relationship between ebv and preidontitis.a comprehensive search was conducted within the pubmed, embase, and wanfang databases up to october 10th, 2016 according to inclusion and exclusion criteria and finally 21 case-control literatures were obtained. the outcomes including odds r ... | 2017 | 28178139 |
| longitudinal viral dynamics in semen during early hiv infection. | multiple viruses coinfect the male genital tract, influencing each other’s replication and perhaps affecting human immunodeficiency virus (hiv) pathogenesis and disease progression. | 2017 | 28174909 |
| [expression of long non-coding rna snhg8 in epstein-barr virus-related gastric cancer and clinical outcome]. | objective: to investigate the expression of long non-coding rna (lncrna) snhg8 in eb virus related gastric cancer and their correlation prognosis. methods: the expression of snhg8 in 93 gastric cancers and 93 cancer-free controls, matched by age and sex, were determined by real-time pcr. eb virus expression was detected by eber in situ hybridization. results: forty-one gastric cancers were eb virus associated. for all gastric cancers, snhg8 expression was 14 times higher (p=0.001) than that in n ... | 2017 | 28173665 |
| clinical value of the epstein-barr virus and p16 status in patients with nasopharyngeal carcinoma: a single-centre study in japan. | the clinical significance of the epstein-barr virus (ebv) status and p16 expression was unknown in nasopharyngeal carcinoma (npc). | 2017 | 28171876 |
| lymphomatoid granulomatosis with pulmonary and gastrointestinal involvement. | we present a rare case of grade ii lymphomatoid granulomatosis (lyg) with pulmonary and gastrointestinal involvement. lyg is considered an epstein-barr virus-driven lymphoproliferative disorder that often presents with multiple nodular lesions in the lungs and sometimes involvement of skin and the central nervous system. although the aetiology is unknown, it is associated with the use of immunosuppressives. involvement of other organ systems is very rare. we successfully treated our patients wit ... | 2017 | 28167690 |
| belatacept after kidney transplantation in adolescents: a retrospective study. | regardless of recipient age at kidney transplantation (ktx), patients are at greatest risk for graft loss in adolescence, partly due to nonadherence to an oral immunosuppressive regimen. belatacept, a non-nephrotoxic, first-in-class immunosuppressant that inhibits costimulation of t cells requires intravenous application only every 4 weeks, potentially leading to better adherence. however, it is only approved for use in adults. we report here the findings of the first study of belatacept in adol ... | 2017 | 28166398 |
| multiple sclerosis-associated retrovirus, epstein-barr virus, and vitamin d status in patients with relapsing remitting multiple sclerosis. | the relationship between infections and autoimmune diseases is complex and there are several reports highlighting the role of human endogenous retroviruses (hervs) in these patients. the levels of multiple sclerosis-associated retrovirus (msrv)-type dna of env gene was measured in peripheral blood mononuclear cells from 52 patients with relapsing-remitting multiple sclerosis (rrms) and 40 healthy controls using specific quantitative pcr (qpcr) analysis. furthermore, we analyzed the status of her ... | 2017 | 28165135 |
| nitrative and oxidative dna damage in infection-related carcinogenesis in relation to cancer stem cells. | infection and chronic inflammation have been recognized as important factors for carcinogenesis. under inflammatory conditions, reactive oxygen species (ros) and reactive nitrogen species (rns) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative dna lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodg) and 8-nitroguanine. the dna damage can cause mutations and has been implicated in inflammation-mediated carcinogenesis. it has bee ... | 2017 | 28163802 |
| anti-pd-1/pd-l1 therapy for infectious diseases: learning from the cancer paradigm. | immune checkpoint pathways regulate optimal host immune responses against transformed cells, induce immunological memory, and limit tissue pathology. conversely, aberrant immune checkpoint activity signifies a poor prognosis in cancer and infectious diseases. host-directed therapy (hdt) via immune checkpoint blockade has revolutionized cancer treatment with therapeutic implications for chronic infections, thus laying the foundation for this review. | 2017 | 28163164 |
| thiopurines and methotrexate use in ibd patients in a biologic era. | although we have been living in the era of biologic therapy for several decades, the use of immunomodulators (primarily thiopurines [azathioprine and mercaptopurine] and less so methotrexate) still remains an important component of the inflammatory bowel disease (ibd) pharmaceutical arsenal. thiopurines as monotherapy exert corticosteroid-sparing effects and can maintain long-term remission in a considerable proportion of patients who have frequent relapses and are or have become mesalazine and/ ... | 2017 | 28160250 |
| methyl-dependent and spatial-specific dna recognition by the orthologous transcription factors human ap-1 and epstein-barr virus zta. | 2017 | 28158710 | |
| epidemiology of multiple herpes viremia in previously immunocompetent patients with septic shock. | systemic reactivations of herpesviruses may occur in intensive care unit (icu) patients, even in those without prior immune deficiency. however, the clinical relevance of these events is uncertain. | 2017 | 28158551 |
| response: re: detection of epstein-barr virus in invasive breast cancers. | 1999 | 28158366 | |
| antiquity of epstein-barr virus, sjögren's syndrome, and hodgkin's disease-historical concordance and discordance. | 2000 | 28158356 | |
| re: detection of epstein-barr virus in invasive breast cancers. | 1999 | 28158352 | |
| re: detection of epstein-barr virus in invasive breast cancers. | 1999 | 28158350 | |
| pattern and significance of asymptomatic elevation of liver enzymes in mycoplasma pneumonia in children. | mycoplasma infection is on the rise in recent times. it usually infects any system, including liver. this study aims to show the significance of elevated liver enzymes in mycoplasma pneumonia and to have a look at future prospects. this is a single-center retrospective study involving 105 children serologically positive for mycoplasma igm and igg antibodies and 50 with community-acquired pneumonia caused by organisms other than mycoplasma and epstein-barr virus from june 2015 to june 2016 and al ... | 2017 | 28155329 |
| regulatory network analysis of epstein-barr virus identifies functional modules and hub genes involved in infectious mononucleosis. | epstein-barr virus (ebv) is the most common cause of infectious mononucleosis (im) and establishes lifetime infection associated with a variety of cancers and autoimmune diseases. the aim of this study was to develop an integrative gene regulatory network (grn) approach and overlying gene expression data to identify the representative subnetworks for im and ebv latent infection (li). after identifying differentially expressed genes (degs) in both im and li gene expression profiles, functional an ... | 2017 | 28155194 |
| rituximab in the treatment of ocular cicatricial pemphigoid: a retrospective cohort study. | the purpose was to evaluate the effectiveness and safety of rituximab (rtx) for the treatment of patients with aggressive ocular cicatricial pemphigoid (ocp). | 2017 | 28154932 |
| molecular diagnostic of cytomegalovirus, epstein barr virus and herpes virus 6 infections among blood donors by multiplex real-time pcr in ouagadougou, burkina faso. | in most developing countries, cytomegalovirus (cmv), epstein barr virus (ebv) and herpes virus 6 (hhv-6) are not diagnosed in blood donors. the aim of this study is to determine the prevalence of these viruses in blood donors from the city of ouagadougou, burkina faso. | 2016 | 28154653 |
| role of tlr9 in oncogenic virus-produced cancer. | nucleic acid recognition by toll-like receptor 9 (tlr9) initiates signaling pathways that regulate the production of proinflammatory cytokines or type i interferons, as well as many other molecules required to initialize the immune response. the use of synthetic oligodeoxynucleotides (odns) has been crucial to emulate the recognition of dna sequences by tlr9. furthermore, odn administration to mice has shown to confer protection against a wide range of viral, bacterial, and parasitic pathogens. ... | 2017 | 28151089 |
| bizarre cell dysplasia of the cervix. | the aim of this study was the characterization of a new subtype of high-grade cervical squamous intraepithelial lesion (hsil) with enlarged cells containing bizarre nuclei: so-called bizarre cell dysplasia (bcd). | 2017 | 28150409 |
| metastatic lymphoepithelioma-like carcinoma of the lung treated with nivolumab: a case report and focused review of literature. | in recent years, significant advances have been made in cancer immunotherapy. here, we present the first report of a patient with lymphoepithelioma-like carcinoma (lelc) of the lung, an epstein-barr virus (ebv)-associated lung cancer, who was treated with nivolumab, a fully human igg4 anti-pd-1 monoclonal antibody. we also carry out a focused review to identify and examine studies of lelc of the lung in the literature. this case report highlights the need to further assess the role of immune che ... | 2016 | 28149767 |
| what should be done in inflammatory bowel disease patients with prior malignancy? | treatment of inflammatory bowel disease (ibd) in patients with prior malignancy is challenging because therapeutic immunosuppression required for controlling ibd activity may increase the risk of cancer recurrence. key messages: contrary to the observations in the post-transplant population, retrospective observational studies of ibd patients with prior malignancy have not demonstrated that immunosuppressive drugs increased significantly the risk of new or recurrent cancer. however, these studie ... | 2017 | 28147366 |
| ebi3 regulates the nk cell response to mouse cytomegalovirus infection. | natural killer (nk) cells are key mediators in the control of cytomegalovirus infection. here, we show that epstein-barr virus-induced 3 (ebi3) is expressed by human nk cells after nkg2d or il-12 plus il-18 stimulation and by mouse nk cells during mouse cytomegalovirus (mcmv) infection. the induction of ebi3 protein expression in mouse nk cells is a late activation event. thus, early activation events of nk cells, such as ifnγ production and cd69 expression, were not affected in ebi3-deficient ( ... | 2017 | 28143936 |
| an unusual case of epstein-barr virus-positive large b-cell lymphoma lacking various b-cell markers. | epstein-barr virus (ebv) is associated with b-cell lymphoma in various conditions, such as immunodeficiency and chronic inflammation. we report an unusual case of ebv-positive diffuse large b-cell lymphoma (dlbcl) lacking the expression of many b-cell markers. | 2017 | 28143608 |
| lymphoepithelial carcinoma in parotid gland related to ebv infection: a case report. | lymphoepithelial carcinoma commonly occurs at the nasopharynx and rarely occurs at other sites in the head and neck region. it is well known to occur at limited patients of local area as asia or arctic circle. related to this point, it is pointed out that this tumor has strong relation with epstein-barr virus (ebv) infection. in this time, we experienced to treat lymphoepithelial carcinoma with metastatic cervical lymph nodes occurring at parotid gland. the morbidity ratio of this tumor is less ... | 2017 | 28139343 |
| comprehensive transcriptome and mutational profiling of endemic burkitt lymphoma reveals ebv type-specific differences. | endemic burkitt lymphoma (ebl) is the most common pediatric cancer in malaria-endemic equatorial africa and nearly always contains epstein-barr virus (ebv), unlike sporadic burkitt lymphoma (sbl) that occurs with a lower incidence in developed countries. given these differences and the variable clinical presentation and outcomes, we sought to further understand pathogenesis by investigating transcriptomes using rna sequencing (rnaseq) from multiple primary ebl tumors compared to sbl tumors. with ... | 2017 | 28137761 |
| acute liver dysfunction not resulting from hepatitis virus in immunocompetent children. | the aim of the present study was to clarify the roles of cytomegalovirus (cmv), epstein-barr virus (ebv), and human herpesvirus 6 (hhv-6) in immunocompetent children with acute liver dysfunction not resulting from hepatitis virus. | 2017 | 28135025 |
| how to use … the monospot and other heterophile antibody tests. | epstein-barr virus (ebv) is a highly prevalent virus, transmitted via saliva, which often causes asymptomatic infection in children but frequently results in infectious mononucleosis in adolescents. heterophile antibody tests, including the monospot test, are red cell or latex agglutination assays, which detect antired cell antibodies produced as part of a polyclonal antibody response occurring during ebv infection. heterophile antibody tests are rapid, cheap and specific tests that can be perfo ... | 2017 | 28130396 |
| efficient evaluation of humoral immune responses by the use of serum pools. | collection and testing of individual serum samples are often used in research to gain knowledge about e.g. the humoral response against bacteria or virus. this is a valid but time-consuming method and might be a waste of valuable serum samples for inefficient research. so far, no study has considered using serum pools as a quick and efficient screening method to confirm or deny hypotheses. | 2017 | 28130033 |
| gestational pityriasis rosea: suggestions for approaching affected pregnant women. | dear editor, pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (hhv)-6 and/or hhv-7 (1). it predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. several patients develop systemic s ... | 2016 | 28128088 |
| vaccination to improve the persistence of cd19car gene-modified t cells in relapsed pediatric acute lymphoblastic leukemia. | trials with second generation cd19 chimeric antigen receptors (car) t-cells report unprecedented responses but are associated with risk of cytokine release syndrome (crs). instead, we studied the use of donor epstein-barr virus-specific t-cells (ebv ctl) transduced with a first generation cd19car, relying on the endogenous t-cell receptor for proliferation. we conducted a multi-center phase i/ii study of donor cd19car transduced ebv ctl in pediatric acute lymphoblastic leukaemia (all). patients ... | 2017 | 28126984 |
| clinicopathological study of 30 cases of peripheral t-cell lymphoma with hodgkin and reed-sternberg-like b-cells from japan. | the presence of hodgkin and reed-sternberg (hrs)-like b-cells in peripheral t-cell lymphoma (ptcl) is rare and its clinicopathological features still remain unclear. here, we describe 30 cases of ptcl with hrs-like b-cells from japan. twenty-three cases (77%) presented evidence of follicular t-helper phenotype (tfh) derivation: 12 were angioimmunoblastic t-cell lymphoma and 11 ptcl with tfh phenotype (ptcl-tfh). the remaining seven cases were diagnosed as ptcl, not otherwise specified (ptcl-nos) ... | 2017 | 28125450 |
| epstein-barr virus induced gene 2 (ebi2) mediates allergen-induced, leukocyte migration into airways. | background leukocyte recruitment to sites of allergic inflammation depends on the local production of priming cytokines, chemokines, and potentially other mediators as well. previously, we showed that eosinophils (eos) express numerous orphan g-protein coupled receptors (gprs) including ebi2. despite its contribution to inflammatory diseases, the role of ebi2 in pulmonary eosinophilia is unknown. objectives to determine whether oxysterol ligands for ebi2 are increased in asthma exacerbation and ... | 2017 | 28125291 |
| pathogenesis of gastric cancer: genetics and molecular classification. | gastric cancer is the fifth most incident and the third most common cause of cancer-related death in the world. infection with helicobacter pylori is the major risk factor for this disease. gastric cancer is the final outcome of a cascade of events that takes decades to occur and results from the accumulation of multiple genetic and epigenetic alterations. these changes are crucial for tumor cells to expedite and sustain the array of pathways involved in the cancer development, such as cell cycl ... | 2017 | 28124158 |
| lentivirus-mediated rnai knockdown of lmp2a inhibits the growth of the epstein-barr-associated gastric carcinoma cell line gt38 in vitro. | in this study, lentivirus-mediated rna interference (rnai) was applied to inhibit latent membrane protein 2a (lmp2a) gene expression, in order to explore the effects of lmp2a silencing on the growth of an epstein-barr virus-associated gastric carcinoma (ebvagc) cell line in vitro. lentivirus-mediated rnai technology was employed to specifically knock down the lmp2a gene in the ebv-positive gastric carcinoma cell line gt38. after infection, reverse transcription-quantitative polymerase chain reac ... | 2017 | 28123488 |
| parvovirus expresses a small noncoding rna that plays an essential role in virus replication. | human bocavirus 1 (hbov1) belongs to the species primate bocaparvovirus of the genus bocaparvovirus of the parvoviridae family. hbov1 causes acute respiratory tract infections in young children and has a selective tropism for the apical surface of well-differentiated human airway epithelia (hae). in this study, we identified an additional hbov1 gene, bocavirus-transcribed small noncoding rna (bocasr), within the 3' noncoding region (nucleotides [nt] 5199 to 5338) of the viral genome of positive ... | 2017 | 28122984 |
| high level of viral microrna-bart20-5p expression is associated with worse survival of patients with epstein-barr virus-associated gastric cancer. | this study analyzed the relationship between several epstein-barr virus (ebv) microrna (mirna) expression profiles and the clinicopathologic features of patients with ebv-associated gastric cancer. the mirna expression was examined in 59 tumor and 39 paired normal mucosal tissues from available formalin-fixed paraffin embedded tissue samples. the expression levels of mir-bamhi fragment a rightward transcript (bart)1-5p, mir-bart4-5p, and mir-bart20-5p were determined using a quantitative real-ti ... | 2017 | 28122341 |
| association of baseline viral serology and sirolimus regimens with kidney transplant outcomes: a 14-year registry-based cohort study in the united states. | the risks for transplant outcomes associated with baseline viral serostatus in kidney transplant recipients (ktr) on sirolimus have not been widely studied. | 2017 | 28121742 |
| the association between circulating tumor cells and epstein-barr virus activation in patients with nasopharyngeal carcinoma. | circulating tumor cells (ctcs) and microemboli (ctm) are attracting increasing attention in medical biology and clinical practice. however, the clinical relevance of ctcs in nasopharyngeal carcinoma (npc) has not yet been ascertained, and no study has focused on the influence of epstein-barr virus (ebv) status on ctcs in npc patients. these issues were therefore examined. | 2017 | 28121221 |
| regulatory t cell effect on cd8(+) t cell responses to human herpesvirus 8 infection and development of kaposi's sarcoma. | we assessed cd8(+) t cell reactivity to human herpesvirus 8 (hhv-8; kaposi's sarcoma [ks]-associated herpesvirus) and the role of cd4(+)cd25(hi)foxp3(+) regulatory t cells (treg) in hhv-8- and hiv-coinfected participants of the multicenter aids cohort study who did or did not develop ks. there were similarly low cd8(+) t cell interferon-γ responses to mhc class i-restricted epitopes of hhv-8 lytic and latent proteins over 5.7 years before ks in participants who developed ks compared to those who ... | 2017 | 28121161 |
| clinicopathological analysis of 12 patients with epstein-barr virus-positive primary intestinal t/natural killer-cell lymphoma (ebv(+) itnkl). | epstein-barr virus-positive (ebv(+) ) intestinal t/natural killer (nk) cell lymphoma (itnkl) is an uncommon tumour with an extremely aggressive clinical behaviour. however, the clinicopathological characteristics of this tumour, including t cell receptor (tcr) phenotype and the patient's background, remain unknown. the aim of this study was to elucidate the detailed clinicopathological profile of ebv(+) itnkl. | 2017 | 28120384 |
| atraumatic splenic rupture secondary to epstein-barr virus infection. | we present a case report of atraumatic splenic rupture secondary to epstein-barr virus (ebv) infection. a woman aged 36 years presented to a london teaching hospital's accident and emergency department with severe abdominal pain following a 6-day history of diarrhoea and vomiting, which had been under review by her gp. a ct scan demonstrated free intraperitoneal fluid and abnormal appearance of her spleen. blood tests demonstrated ebv infection with positive serology and leucocytosis. she underw ... | 2017 | 28119438 |
| molecular classification of gastric cancer. | gastric cancer is among the most common cancers worldwide. despite declining incidences, the prognosis remains dismal in western countries and is better in asian countries with national cancer screening programs. complete endoscopic or surgical resection of the primary tumor with or without lymphadenectomy offers the only chance of cure in the early stage of the disease. survival of more locally advanced gastric cancers was improved by the introduction of perioperative, adjuvant and palliative c ... | 2017 | 28118758 |
| epstein-barr virus gene expression and latency pattern in gastric carcinomas: a systematic review. | a systematic review of literature was conducted to identify all published reports regarding the expression of epstein-barr virus (ebv) proteins/transcripts and ebv latency patterns in ebv-associated gastric carcinomas (ebvagc). | 2017 | 28118740 |
| a simple red blood cell lysis method for the establishment of b lymphoblastoid cell lines. | a number of methods exist for the transformation of b lymphocytes by the epstein barr virus in vitro into immortalized cell lines. we have developed a new method with a powerful and simple strategy for the establishment of b-lcls, the red blood cell lysis method. this method simplified the pbmc separation procedure with red blood cell removal, and used as little as 0.5 ml of whole blood for establishing ebv-immortalized cell lines, which can proliferate to large cell numbers in a relatively shor ... | 2017 | 28117797 |
| a rare presentation of isolated cns posttransplantation lymphoproliferative disorder. | posttransplantation lymphoproliferative disorder (ptld) is a recognized and extremely morbid complication of solid organ transplantation, but central nervous system involvement, particularly in isolation, is rare. there are no standardized treatment strategies for ptld, though commonly used strategies include reduction of immunosuppression, chemotherapy, rituximab, radiation, and surgery. we present a case of an unusual morphologic variant of primary central nervous system ptld with successful r ... | 2017 | 28116196 |
| a supporting role of chinese national immortalized cell bank in life science research. | a biorepository of human samples is essential to support the research of life science. lymphoblastoid b cell line (lcl), which is easy to be prepared and can reproduce indefinitely, is a convenient form of sample preservation. lcls are established from human b cells transformed by epstein-barr virus (ebv). chinese national immortalized cell bank has preserved human lcls from different ethnic groups in china. as there are many studies on the nature of lcls and public available resources with geno ... | 2017 | 28115308 |
| hpv and systemic lupus erythematosus: a mosaic of potential crossreactions. | etiology, pathogenesis, and immunology of systemic lupus erythematosus (sle) form a complex, still undeciphered picture that recently has been further made complicated by a new factor of morbidity: human papillomaviruses (hpvs). indeed, a prevalence of hpv infections has been reported among sle patients. searching for molecular mechanisms that might underlie and explain the relationship between hpv infection and sle, we explored the hypothesis that immune responses following hpv infection may cr ... | 2017 | 28111707 |
| cerebrospinal fluid in a small cohort of patients with multiple sclerosis was generally free of microbial dna. | multiple sclerosis (ms) is a common cause of non-traumatic neurologic disability with high incidence in many developed countries. although the etiology of the disease remains elusive, it is thought to entail genetic and environmental causes, and microbial pathogens have also been envisioned as contributors to the phenotype. we conducted a metagenomic survey in cerebrospinal fluid (csf) from 28 ms patients and 15 patients suffering other type of neurological conditions. we detected bacterial read ... | 2016 | 28111617 |
| [current events in immunotherapy for upper aerodigestive tract cancer]. | head and neck (hn) carcinomas (mostly represented by squamous cell carcinomas [scc]) still have a poor prognosis, which could be dramatically improved with immunotherapy. tumor's microenvironment changes, caused by many endogenous or exogenous events, can correlate with prognosis and therapeutic response. here, we review recent data regarding hnscc, nasopharyngeal carcinomas (npc) and salivary gland malignant tumors, all three being potential target of immunotherapies. about half of hnscc exhibi ... | 2017 | 28111039 |
| an epstein-barr virus susceptible immature t-cell line, will4, established from a patient with t-lymphoblastic lymphoma bearing cd21 and a clonal ebv genome. | we managed a patient with an epstein-barr virus-associated t-cell lymphoblastic lymphoma. mediastinal tumor cells at initial admission were positive for cd4, cd8, and tdt. interestingly, a lymph node at necropsy was compatible for a cd4-positive peripheral t-cell lymphoma without cd8 and tdt expression, suggesting a different phenotype from the mediastinal tumor. tumor cells in pleural effusion continued to proliferate in in vitro and were designated as will4. will4 cells were positive for cd3, ... | 2017 | 28110206 |
| human immunity against ebv-lessons from the clinic. | the mammalian immune system has evolved over many millennia to be best equipped to protect the host from pathogen infection. in many cases, host and pathogen have coevolved, each acquiring sophisticated ways of inducing or protecting from disease. epstein-barr virus (ebv) is a human herpes virus that infects >90% of individuals. despite its ubiquity, infection by ebv is often subclinical; this invariably reflects the necessity of the virus to preserve its host, balanced with sophisticated host i ... | 2017 | 28108590 |
| epstein-barr-virus-related mucocutaneous ulceration that mimics oral squamous cell carcinoma: the importance of recognising this new condition. | we report a case and present a literature search of the relatively newly reported condition of epstein barr virus (ebv)-related mucocutaneous ulceration. ebv-related mucocutaneous ulcers clinically present as oral squamous cell carcinoma (oscc) in immunocompromised elderly patients but usually resolve by stopping or modifying the medication. as the two conditions can present in a similar way, and the management of each is totally different, this case highlights the importance of recognising this ... | 2017 | 28108051 |
| pre-treatment serum inflammatory cytokines as survival predictors of patients with nasopharyngeal carcinoma receiving chemoradiotherapy. | the present study aimed to examine the predictability of pre-treatment serum levels of interleukin (il)-1β, il-6 and tumor necrosis factor (tnf)-α for determining the outcome of patients with nasopharyngeal carcinoma (npc) assigned for chemoradiotherapy. a total of 35 patients with npc were subjected to clinical examination and evaluation of performance status using karnofsky scoring. nasopharyngoscopy was performed for evaluation and to obtain a biopsy. blood samples were obtained pre- and post ... | 2016 | 28105362 |
| trim5α promotes ubiquitination of rta from epstein-barr virus to attenuate lytic progression. | replication and transcription activator (rta), a key protein expressed by epstein-barr virus (ebv) during the immediate-early stage of the lytic cycle, is responsible for the activation of viral lytic genes. in this study, gst-pulldown and coimmunoprecipitation assays showed that rta interacts in vitro and in vivo with trim5α, a host factor known to be involved in the restriction of retroviral infections. confocal microscopy results revealed that rta colocalizes with trim5α in the nucleus during ... | 2016 | 28105027 |
| structural basis for the regulation of nuclear import of epstein-barr virus nuclear antigen 1 (ebna1) by phosphorylation of the nuclear localization signal. | epstein-barr virus (ebv) nuclear antigen 1 (ebna1) is expressed in every ebv-positive tumor and is essential for the maintenance, replication, and transcription of the ebv genome in the nucleus of host cells. ebna1 is a serine phosphoprotein, and it has been shown that phosphorylation of s385 in the nuclear localization signal (nls) of ebna1 increases the binding affinity to the nuclear import adaptor importin-α1 as well as importin-α5, and stimulates nuclear import of ebna1. to gain insights in ... | 2017 | 28104399 |
| clinical impact of serum survivin positivity and tissue expression of ebv-encoded rna in diffuse large b-cell lymphoma patients treated with rituximab-chop. | survivin is an inhibitor of apoptosis and is upregulated by epstein-barr virus (ebv) latent genes. given the frequent association of ebv with lymphoid malignancies, survivin is expected to have prognostic value in diffuse large b-cell lymphoma (dlbcl). thus, we measured the pretreatment serum level of survivin in dlbcl patients and analyzed its association with survival outcome and ebv status, as represented by ebv-encoded rna (eber) in dlbcl. pretreatment serum survivin level was measured in pa ... | 2017 | 28099151 |
| exome and genome sequencing of nasopharynx cancer identifies nf-κb pathway activating mutations. | nasopharyngeal carcinoma (npc) is an aggressive head and neck cancer characterized by epstein-barr virus (ebv) infection and dense lymphocyte infiltration. the scarcity of npc genomic data hinders the understanding of npc biology, disease progression and rational therapy design. here we performed whole-exome sequencing (wes) on 111 micro-dissected ebv-positive npcs, with 15 cases subjected to further whole-genome sequencing (wgs), to determine its mutational landscape. we identified enrichment f ... | 2017 | 28098136 |
| burkitt lymphoma in adolescents and young adults: management challenges. | about one-half of all burkitt lymphoma (bl) patients are younger than 40 years, and one-third belong to the adolescent and young adult (aya) subset, defined by an age between 15 and 25-40 years, based on selection criteria used in different reports. bl is an aggressive b-cell neoplasm displaying highly characteristic clinico-diagnostic features, the biologic hallmark of which is a translocation involving immunoglobulin and c-myc genes. it presents as sporadic, endemic, or epidemic disease. endem ... | 2017 | 28096698 |
| semisynthesis of (-)-rutamarin derivatives and their inhibitory activity on epstein-barr virus lytic replication. | (+)-rutamarin inhibits ebv lytic dna replication with an ic50 of 7.0 μm. (-)-chalepin, a (-)-rutamarin derivative, was isolated from the whole plant of ruta graveolens and used as a precursor of (-)-rutamarin. altogether, 28 (-)-rutamarin derivatives were synthesized starting from (-)-chalepin. of these, 16 compounds (2a-e, 3b-e, 3g, 4f, 4k, 4m-p) were found to be more potent against ebv lytic dna replication than (-)-chalepin. compounds 4m, 4n, and 4p exhibited ic50 values of 1.5, 0.32, and 0.8 ... | 2017 | 28093914 |
| subacute demyelinating polyradiculoneuropathy complicating epstein-barr virus infection in gata2 haploinsufficiency. | autosomal dominant haploinsufficiency of gata2 causes monocytopenia and natural killer cell lymphopenia, resulting in predisposition to mycobacterial, fungal, and viral infections. | 2017 | 28093780 |
| the most important questions in cancer research and clinical oncology : question 1. could the vertical transmission of human papilloma virus (hpv) infection account for the cause, characteristics, and epidemiology of hpv-positive oropharyngeal carcinoma, non-smoking east asian female lung adenocarcinoma, and/or east asian triple-negative breast carcinoma? | specific research foci: (1) mouse models of gamma-herpes virus-68 (γhv-68) and polyomavirus (pyv) infections during neonatal versus adult life. (2) for human papilloma virus (hpv)-positive oropharyngeal carcinoma (opc)-(a) asking the question: is oral sex a powerful carcinogen? (b) examining the evidence for the vertical transmission of hpv infection. (c) examining the relationship between hpv and epstein-barr virus (ebv) infections and nasopharyngeal cancer (npc) in west european, east european ... | 2017 | 28093081 |
| comprehensive assessment of peripheral blood tcrβ repertoire in infectious mononucleosis and chronic active ebv infection patients. | epstein-barr virus (ebv) primary infection is usually asymptomatic, but it sometimes progresses to infectious mononucleosis (im). occasionally, some people develop chronic active ebv infection (caebv) with underlying immunodeficiency, which belongs to a continuous spectrum of ebv-associated lymphoproliferative disorders (ebv(+) lpd) with heterogeneous clinical presentations and high mortality. it has been well established that t cell-mediated immune response plays a critical role in the disease ... | 2017 | 28091735 |
| gastrointestinal post-transplant lymphoproliferative disorder with rapidly forming characteristic lesions after cord blood transplantation: a report of two cases. | epstein-barr virus (ebv)-related post-transplant lymphoproliferative disorder (ptld) frequently involves the gastrointestinal tract, but the endoscopic characteristics of this condition have not been discussed in detail. we report two cases of ebv-related ptld involving rapidly forming characteristic lesions. case 1 was a 60-year-old man with acute myeloid leukemia who underwent cord blood transplantation (cbt) after which he initially achieved complete remission (cr). he developed nausea and vo ... | 2017 | 28090016 |
| epstein-barr virus and renal transplantation. | epstein-barr virus (ebv) is a gamma herpesvirus associated with diseases ranging from asymptomatic viremia to post-transplant malignancies in kidney transplant recipients. ebv specifically is associated with post-transplantation lymphoproliferative disorder (ptld), in kidney transplant recipients, with increased risk in ebv seronegative patients with ebv seropositive donors on intensified immunosuppression. the diagnosis of ptld relies on clinical suspicion plus tissue biopsy with polymerase cha ... | 2017 | 28089555 |
| [tnfaip3 deletion status in classical hodgkin lymphoma and its relation to epstein-barr virus]. | objective: to investigate the tnfaip3/a20 abnormalities and its association with epstein-barr virus (ebv) in classical hodgkin lymphoma (chl). methods: formalin-fixed, paraffinembedded tissue blocks of 54 chl patients were collected and subjected to the construction of tissue microarray (tma) for further analyses. ebv status was evaluated by in situ hybridization (ish) for eber1/2 and immunohistochemistry (ihc) with anti-lmp-1 antibody. fluorescence in situ hybridization (fish) and ihc were perf ... | 2016 | 28088970 |
| epstein-barr virus-positive mucocutaneous ulcer. | 2017 | 28088274 | |
| familial outbreak of eruptive pseudoangiomatosis with dermoscopic and histopathologic correlation. | 2017 | 28087016 | |
| [gastric tumors and tumor precursors]. | gastric cancer is the fifth (men) and sixth (women) most common cause of cancer-related death in germany. despite a declining incidence of distal gastric cancer, the prognosis remains dismal: the 5‑year survival rate ranges between 35% for women and 31% for men. the majority are adenocarcinomas, which occur sporadically, familial or hereditary. adenomas and intraepithelial neoplasms are considered as precursor lesions. recently, whole genome sequencing and comprehensive molecular profiling descr ... | 2017 | 28084526 |
| hhv8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma. | human herpesvirus 8 (hhv8)-associated lymphoid proliferations are uncommon and poorly characterized disorders mainly affecting immunosuppressed patients, especially with hiv infection. they encompass different diseases with overlapping features that complicate their classification. in addition, the role of hhv8 in reactive lymphoid hyperplasia is not well known. to analyze the clinicopathological spectrum of these lesions, we have reviewed 66 biopsies of 61 patients with hhv8 infection. all case ... | 2017 | 28084335 |
| [differential diagnosis of the viral etiology of suspected mumps in a population with high vaccine coverage]. | in this study, buccal swabs from patients with the clinical picture of parotitis epidemica in whom mumps virus (mv) infection was not confirmed by direct detection or serologically were tested. the aim was to detect by molecular methods nucleic acids (nas) of other respiratory viruses possibly involved in salivary gland swelling. at the same time, paired sera, if available, were tested. | 2016 | 28078898 |
| carcinoma-risk variant of ebna1 deregulates epstein-barr virus episomal latency. | epstein-barr virus (ebv) latent infection is a causative co-factor for endemic nasopharyngeal carcinoma (npc). npc-associated variants have been identified in ebv-encoded nuclear antigen ebna1. here, we solve the x-ray crystal structure of an npc-derived ebna1 dna binding domain (dbd) and show that variant amino acids are found on the surface away from the dna binding interface. we show that npc-derived ebna1 is compromised for dna replication and episome maintenance functions. recombinant virus ... | 2017 | 28077791 |
| latent membrane protein 1 (lmp1) and lmp2a collaborate to promote epstein-barr virus-induced b cell lymphomas in a cord blood-humanized mouse model but are not essential. | epstein-barr virus (ebv) infection is associated with b cell lymphomas in humans. the ability of ebv to convert human b cells into long-lived lymphoblastoid cell lines (lcls) in vitro requires the collaborative effects of ebna2 (which hijacks notch signaling), latent membrane protein 1 (lmp1) (which mimics cd40 signaling), and ebv-encoded nuclear antigen 3a (ebna3a) and ebna3c (which inhibit oncogene-induced senescence and apoptosis). however, we recently showed that an lmp1-deleted ebv mutant i ... | 2017 | 28077657 |
| phyloepidemiological analysis reveals that viral divergence led to the paucity of simian immunodeficiency virus sivmus/gsn/mon infections in wild populations. | human immunodeficiency virus type 1 (hiv-1) is the result of cross-species transmission of simian immunodeficiency virus from chimpanzees (sivcpz). sivcpz is a chimeric virus which shares common ancestors with viruses infecting red-capped mangabeys and a subset of guenon species. the epidemiology of siv infection in hominoids is characterized by low prevalences and an uneven geographic distribution. surveys in cameroon indicated that two closely related members of the guenon species subset, must ... | 2017 | 28077632 |
| the global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. | by using data from the international agency for research on cancer publication cancer incidence in 5 continents and globocan, this report provides the first consolidated global estimation of the subsite distribution of new cases of lip, oral cavity, and pharyngeal cancers by country, sex, and age for the year 2012. major geographically based, sex-based, and age-based variations in the incidence of lip, oral cavity, and pharyngeal cancers by subsite were observed. lip cancers were highly frequent ... | 2017 | 28076666 |
| isolation and characterization of an hiv-1 envelope glycoprotein-specific b-cell from an immortalized human naïve b-cell library. | with the recent development of single b-cell cloning techniques, an increasing number of human immunodeficiency virus type 1 (hiv-1)-specific broadly neutralizing antibodies have been isolated since 2009. however, knowledge regarding hiv-1-specific b cells in vivo is limited. in this study, an hiv-1-specific b-cell line was established using healthy pbmc donors by the highly efficient epstein-barr virus transformation method to generate immortalized human naïve b-cell libraries. the enrichment o ... | 2017 | 28073404 |
| [paraffin-embedded tissue fragment suspension: a novel method for quality control preparation in in-situ hybridization for epstein-barr virus encoded rna]. | 2017 | 28072979 | |
| [clinical and immunological analysis of patients with activated phosphoinositide 3-kinase δ syndrome resulting from pik3cd mutation]. | objective: to explore the clinical and immunological features, gene mutations, treatment and prognosis in patients with activated phosphoinositide 3-kinase δ syndrome (apds) caused by pik3cd gene heterozygous germline mutation. method: the data of clinical, immunological phenotype, treatment, and prognosis of 15 patients with apds, who visited children's hospital of chongqing medical university, peking union medical college hospital, and shenzhen children's hospital from june 2014 to november 20 ... | 2017 | 28072954 |
| nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection. | inhalation of environmental (nano) particles (np) as well as persistent herpesvirus-infection are potentially associated with chronic lung disease and as both are omnipresent in human society a coincidence of these two factors is highly likely. we hypothesized that np-exposure of persistently herpesvirus-infected cells as a second hit might disrupt immune control of viral latency, provoke reactivation of latent virus and eventually lead to an inflammatory response and tissue damage. | 2017 | 28069010 |
| transplant infectious diseases: a review of the scientific registry of transplant recipients published data. | the scientific registry of transplant recipients (srtr) serves to collect data on organ transplants performed in the united states. although the infectious diseases data are limited and include mostly pretransplant serologies and other nonspecific infection-related outcomes, this multicenter data collection allows for insightful national data and the ability to monitor trends over time. we reviewed the published concise reports for each organ type in srtr reports containing data from 2005 to 201 ... | 2017 | 28066999 |
| the autoimmune risk gene zmiz1 is a vitamin d responsive marker of a molecular phenotype of multiple sclerosis. | multiple sclerosis (ms) is a neurological condition driven in part by immune cells from the peripheral circulation, the targets for current successful therapies. the autoimmune and ms risk gene zmiz1 is underexpressed in blood in people with ms. we show that, from three independent sets of transcriptomic data, expression of zmiz1 is tightly correlated with that of hundreds of other genes. further we show expression is partially heritable (heritability 0.26), relatively stable over time, predomin ... | 2017 | 28063629 |
| chaetocin reactivates the lytic replication of epstein-barr virus from latency via reactive oxygen species. | oxidative stress, regarded as a negative effect of free radicals in vivo, takes place when organisms suffer from harmful stimuli. some viruses can induce the release of reactive oxygen species (ros) in infected cells, which may be closely related with their pathogenicity. in this report, chaetocin, a fungal metabolite reported to have antimicrobial and cytostatic activity, was studied for its effect on the activation of latent epstein-barr virus (ebv) in b95-8 cells. we found that chaetocin rema ... | 2017 | 28063010 |
| a comprehensive analysis and immunobiology of autoimmune neurological syndromes during the zika virus outbreak in cúcuta, colombia. | we have focused on the epidemiology and immunobiology of zika virus (zikv) infection and factors associated with the development of guillain-barré syndrome (gbs) and other neurological syndromes in cúcuta, the capital of north santander department, colombia. data of patients with zikv disease reported to the national population-based surveillance system were used to calculate the basic reproduction number (r0) and the attack rates (ars) as well as to develop epidemiological maps. patients with n ... | 2017 | 28062188 |
| inkt and memory b-cell alterations in hhv-8 multicentric castleman disease. | human herpesvirus 8 (hhv-8) is the causative agent of kaposi sarcoma (ks) and multicentric castleman disease (mcd), a life-threatening, virally induced b-cell lymphoproliferative disorder. hhv-8 is a b-lymphotropic γ-herpesvirus closely related to the epstein-barr virus (ebv). invariant natural killer t (inkt) cells are innate-like t cells that play a role in antiviral immunity, specifically in controlling viral replication in ebv-infected b cells. decline of inkt cells is associated with age or ... | 2017 | 28060720 |
| virus-associated neoplasms of the nasopharynx and sinonasal tract: diagnostic problems. | a significant fraction of nasopharyngeal and sinonasal tumors are associated with epstein-barr virus (ebv) or human papillomavirus (hpv). nasopharyngeal carcinoma (npc) and extranodal nk/t-cell lymphoma harbor ebv in practically all cases, although a small proportion of cases of the former harbor hpv. sinonasal inverted papillomas harbor hpv in about 25% of cases. sinonasal squamous cell carcinomas harbor transcriptionally active hpv in about 20% of cases, and limited data suggest that this subs ... | 2017 | 28060369 |
| identification of distinct subgroups of ebv-positive post-transplant diffuse large b-cell lymphoma. | post-transplantation lymphoproliferative disorder is an aggressive complication of transplantation, most frequently of diffuse large b-cell lymphoma morphology and associated with epstein-barr virus (ebv) infection/reactivation. in this study the microenvironment of ebv(+) (n=23) and ebv(-) (n=9) post-transplant non-germinal center b-cell diffuse large b-cell lymphoma was characterized. of ebv(+) cases somatic hypermutation analysis, gene expression profiling, and extensive phenotyping were perf ... | 2017 | 28059091 |
| persistent epstein-barr viral load in epstein-barr viral naïve pediatric heart transplant recipients: risk of late-onset post-transplant lymphoproliferative disease. | to examine the risk of late-onset post-transplant lymphoproliferative disorder (ptld) in the presence of persisting high epstein-barr virus (ebv) in ebv naïve pediatric heart transplant (ht) recipients. | 2016 | 28058224 |
| inhibition of epstein-barr virus reactivation by the flavonoid apigenin. | lytic reactivation of ebv has been reported to play an important role in human diseases, including npc carcinogenesis. inhibition of ebv reactivation is considered to be of great benefit in the treatment of virus-associated diseases. for this purpose, we screened for inhibitory compounds and found that apigenin, a flavonoid, seemed to have the ability to inhibit ebv reactivation. | 2017 | 28056971 |
| therapeutic vaccine targeting epstein-barr virus latent protein, lmp1, suppresses lmp1-expressing tumor growth and metastasis in vivo. | in endemic area, nasopharyngeal carcinoma (npc) tumor cells harbor ebv latent infection and expresses viral antigens such as ebna1, lmp1 and lmp2. in this study, we established a npc-mimicry animal model and assessed the therapeutic potential of lmp1 vaccine. | 2017 | 28056887 |
| [the understanding of epstein-barr virus associated lymphoproliferative disorder]. | in recent years, there are increasing articles concerning epstein-barr virus associated lymphoproliferative disorder (ebv+ lpd), and the name of ebv+ lpd is used widely. however, the meaning of ebv+ lpd used is not the same, which triggered confusion of the understanding and obstacles of the communication. in order to solve this problem. literature was reviewed with combination of our cases to clarify the concept of ebv+ lpd and to expound our understanding about it. in general, it is currently ... | 2016 | 28056294 |
| high levels of ebv-encoded rna 1 (eber1) trigger interferon and inflammation-related genes in keratinocytes expressing hpv16 e6/e7. | different types of cells infected with epstein-barr virus (ebv) can release exosomes containing viral components that functionally affect neighboring cells. previously, we found that ebv was localized mostly in infiltrating lymphocytes within the stromal layer of cervical lesions. in this study, we aimed to determine effects of exosome-transferred ebv-encoded rnas (ebers) on keratinocytes expressing human papillomavirus (hpv) 16 e6/e7 (donori-hpv16 hfks). lipid transfection of in vitro-transcrib ... | 2017 | 28056059 |
| epstein-barr virus-encoded latent membrane protein 1 upregulates glucose transporter 1 transcription via the mtorc1/nf-κb signaling pathways. | accumulating evidence indicates that oncogenic viral protein plays a crucial role in activating aerobic glycolysis during tumorigenesis, but the underlying mechanisms are largely undefined. epstein-barr virus (ebv)-encoded latent membrane protein 1 (lmp1) is a transmembrane protein with potent cell signaling properties and has tumorigenic transformation property. activation of nf-κb is a major signaling pathway mediating many downstream transformation properties of lmp1. here we report that acti ... | 2017 | 28053105 |
| ebi2 expression and function: robust in memory lymphocytes and increased by natalizumab in multiple sclerosis. | the interaction between oxysterols and the g protein-coupled receptor epstein-barr virus-induced gene 2 (ebi2) fine-tunes immune cell migration, a mechanism efficiently targeted by several disease-modifying treatments developed to treat multiple sclerosis (ms), such as natalizumab. we previously showed that memory cd4(+) t lymphocytes migrate specifically in response to 7α,25-dihydroxycholesterol (7α,25-ohc) via ebi2 in the ms murine model experimental autoimmune encephalomyelitis. however, the ... | 2017 | 28052250 |
| the biological properties of different epstein-barr virus strains explain their association with various types of cancers. | the epstein-barr virus (ebv) is etiologically associated with the development of multiple types of tumors, but it is unclear whether this diversity is due to infection with different ebv strains. we report a comparative characterization of snu719, gp202, and yccel1, three ebv strains that were isolated from gastric carcinomas, m81, a virus isolated in a nasopharyngeal carcinoma and several well-characterized laboratory type a strains. we found that b95-8, akata and gp202 induced cell growth more ... | 2017 | 28052012 |
| unusual presentation of gianotti-crosti syndrome due to epstein-barr virus infection. | gianotti-crosti syndrome (gcs) is viral exanthema of childhood. it typically presents with a symmetric erythematous papular and papulovesicular eruption. it has been classically associated with hepatitis b virus, as well as rarely with epstein-barr virus (ebv). we report a case of gcs related to ebv infection without the classical systemic symptoms in a five-year-old male patient. | 2016 | 28050291 |
| nitrative and oxidative dna damage in infection-related carcinogenesis in relation to cancer stem cells. | infection and chronic inflammation have been recognized as important factors for carcinogenesis. under inflammatory conditions, reactive oxygen species (ros) and reactive nitrogen species (rns) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative dna lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodg) and 8-nitroguanine. the dna damage can cause mutations and has been implicated in inflammation-mediated carcinogenesis. it has bee ... | 2016 | 28050219 |
| mesenchymal stem cells ameliorate b-cell-mediated immune responses and increase il-10-expressing regulatory b cells in an ebi3-dependent manner. | effector b cells are central contributors to the development of autoimmune disease by activating autoreactive t cells, producing pro-inflammatory cytokines and organizing ectopic lymphoid tissue. conversely, il-10-producing regulatory b (breg) cells have pivotal roles in maintaining immunological tolerance and restraining excessive inflammation in autoinflammatory disease. thus, regulating the equilibrium between antibody-producing effector b cells and breg cells is critical for the treatment of ... | 2017 | 28042143 |
| environmental factor and inflammation-driven alteration of the total peripheral t-cell compartment in granulomatosis with polyangiitis. | autoimmune diseases are initiated by a combination of predisposing genetic and environmental factors resulting in self-perpetuating chronic inflammation and tissue damage. autoantibody production and an imbalance of effector and regulatory t-cells are hallmarks of autoimmune dysregulation. while expansion of circulating effector memory t-cells is linked to disease pathogenesis and progression, the causes driving alterations of the peripheral t-cell compartment have remained poorly understood so ... | 2017 | 28040323 |