Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| suppression of the pelo protein by wolbachia and its effect on dengue virus in aedes aegypti. | the endosymbiont wolbachia is known to block replication of several important arboviruses, including dengue virus (denv), in the mosquito vector aedes aegypti. so far, the exact mechanism of this viral inhibition is not fully understood. a recent study in drosophila melanogaster has demonstrated an interaction between the pelo gene and drosophila c virus. in this study, we explored the possible involvement of the pelo protein, that is involved in protein translation, in wolbachia-mediated antivi ... | 2018 | 29641562 |
| exploring mosquito fauna of majuro atoll (republic of marshall islands) in the context of zika outbreak. | first autochthonous zika clinical case was reported in the republic of marshall islands (rmi) on majuro atoll in february 2016. an entomological survey of mosquito larvae and adult populations was carried out in four areas of majuro, the most populated atoll of rmi encompassing different habitats (forest, rural, or urban) including some with confirmed clinical zika cases to evaluate which mosquito species could be involved in the zika transmission. a total of 2,367 immature and adult mosquito sp ... | 2018 | 29635382 |
| a sex-structured model with birth pulse and release strategy for the spread of wolbachia in mosquito population. | dengue fever is one of the most important diseases causing illness and death all over the world, which brings tremendous threat to peoples' life and property security, especially in the undeveloped areas. the main vector, aedes aegypti, must be controlled to prevent the transmission of dengue. there are a variety of methods to control it. wolbachia is an innovative bacterium which breaks the dengue transmission cycle for its characteristics of cytoplasmic incompatibility and maternal transmissio ... | 2018 | 29625205 |
| efficacy of aedes aegypti control by indoor ultra low volume (ulv) insecticide spraying in iquitos, peru. | aedes aegypti is a primary vector of dengue, chikungunya, zika, and urban yellow fever viruses. indoor, ultra low volume (ulv) space spraying with pyrethroid insecticides is the main approach used for ae. aegypti emergency control in many countries. given the widespread use of this method, the lack of large-scale experiments or detailed evaluations of municipal spray programs is problematic. | 2018 | 29624581 |
| overview of dengue and zika virus similarity, what can we learn from the saudi experience with dengue fever? | there is high public health alert in the kingdom of saudi arabia concerning zika virus infection. so far, there is no reported outbreak. so are we at risk of this disease? reviewing the literature of recent outbreaks of other infectious diseases in saudi arabia may clarify the situation. it is evident that there is some similarity between zika and dengue regarding vector (aedes aegypti) which is available in the kingdom of saudi arabia. furthermore, they have similar transmission process and the ... | 2019 | 29623022 |
| erratum to "comparative oviposition site selection in containers by aedes aegypti and aedes albopictus (diptera: culicidae) from florida". | 2018 | 29618025 | |
| mosquito saliva: the hope for a universal arbovirus vaccine? | arthropod-borne viruses (arboviruses) are taxonomically diverse causes of significant morbidity and mortality. in recent decades, important mosquito-borne viruses such as west nile, chikungunya, dengue, and zika have re-emerged and spread widely, in some cases pandemically, to cause serious public health emergencies. there are no licensed vaccines against most of these viruses, and vaccine development and use has been complicated by the number of different viruses to protect against, by subtype ... | 2018 | 29617849 |
| the potential impacts of 21st century climatic and population changes on human exposure to the virus vector mosquitoaedes aegypti. | the mosquitoaedes (ae). aegyptitransmits the viruses that cause dengue and chikungunya, two globally-important vector-borne diseases. we investigate how choosing alternate emissions and/or socioeconomic pathways may modulate future human exposure toae. aegypti. occurrence patterns forae. aegyptifor 2061-2080 are mapped globally using empirically downscaled air temperature and precipitation projections from the community earth system model, for the representative concentration pathway (rcp) 4.5 a ... | 2018 | 29610543 |
| identification of hub genes and pathways in zika virus infection using rna-seq data: a network-based computational approach. | zika virus (zikv), a single-strand rna flavivirus, is transmitted primarily through aedes aegypti. the recent outbreaks in america and unexpected association between zikv infection and birth defects have triggered the global attention. this vouches to understand the molecular mechanisms of zikv infection to develop effective drug therapy. a systems-level understanding of biological process affected by zikv infection in fetal brain sample led us to identify the candidate genes for pharmaceutical ... | 2018 | 29608426 |
| a comparative analysis of corpora allata-corpora cardiaca microrna repertoires revealed significant changes during mosquito metamorphosis. | the corpora allata (ca) are a pair of endocrine glands with neural connections to the brain and close association with another neuroendocrine organ, the corpora cardiaca (cc). the ca from adult female aedes aegypti mosquitoes synthesize fluctuating levels of juvenile hormone (jh), which have been linked to the ovarian development and are influenced by nutritional signals. in this study, we investigated the potential involvement of micrornas (mirnas), a type of small non-coding rnas, in the regul ... | 2018 | 29605533 |
| pyrethroid resistance persists after ten years without usage against aedes aegypti in governmental campaigns: lessons from são paulo state, brazil. | aedes aegypti, vector of dengue, chikungunya and zika viruses, is found at high densities in tropical urban areas. the dissemination of this vector is partially the consequence of failures in current vector control methods, still mainly relying upon insecticides. in the state of são paulo (sp), brazil, public health managers employed pyrethroids against ae. aegypti adults from 1989 to 2000, when a robust insecticide resistance monitoring system detected resistance to pyrethroids in several ae. a ... | 2018 | 29601580 |
| zika virus pathogenesis in infant mice after natural transmission by the bite of infected mosquitoes. | the objective of this study was to understand natural disease progression in infant cd1 mice after the bite of aedes aegypti mosquitoes infected by the zika virus (zikv, mr-766 strain). | 2018 | 29597193 |
| mosquito responses to trait- and density-mediated interactions of predation. | mosquito and predatory larvae often share the same habitat. predators may influence mosquito prey populations through both lethal effect and non-lethal pathways. a series of experimental manipulations were used to distinguish between lethal (density-mediated interaction) and non-lethal (trait-mediated interaction) effects in a model system comprised of invasive prey mosquito, aedes aegypti, and a predatory mosquito toxorhynchites rutilus. treatments with predators present or manipulations mimick ... | 2018 | 29594613 |
| commentary: zika virus in the americas-yet anotherarbovirusthreat. | 2018 | 29593683 | |
| effect of relaxation of deltamethrin pressure on metabolic resistance in a pyrethroid-resistant aedes aegypti (diptera: culicidae) strain harboring fixed p989p and g1016g kdr alleles. | mutation of the voltage-gated sodium channel genes or knockdown resistance (kdr) and metabolic resistance in aedes aegypti (l.) (diptera: culicidae) are important resistance mechanisms against pyrethroids. the present study investigated the effect of relaxation of deltamethrin selection pressure on the level of mixed-function oxidases (mfo), when the allele frequency of s989p+v1016g mutations is fixed in a resistant ae. aegypti strain (upk-r) from chiang mai, thailand. the mosquitoes were divide ... | 2018 | 29590378 |
| insect-pathogen interactions: contribution of viral adaptation to the emergence of vector-borne diseases, the example of chikungunya. | the emergence or re-emergence of vector borne diseases represents a major public health problem. in general, therapeutic or prophylactic treatments along with vaccines are missing or inefficient, emphasizing the need for increased control of vector populations. understanding the interactions of human pathogens with their insect vectors will aid us in our understanding of viral emergence and the dynamics of these events. chikungunya virus (chikv) is a mosquito-borne virus that typically causes in ... | 2015 | 29588001 |
| diverse laboratory colonies of aedes aegypti harbor the same adult midgut bacterial microbiome. | host-associated microbes, collectively known as the microbiota, play an important role in the biology of multicellular organisms. in mosquito vectors of human pathogens, the gut bacterial microbiota influences vectorial capacity and has become the subject of intense study. in laboratory studies of vector biology, genetic effects are often inferred from differences between geographically and genetically diverse colonies of mosquitoes that are reared in the same insectary. it is unclear, however, ... | 2018 | 29587819 |
| a vaccinia-based single vector construct multi-pathogen vaccine protects against both zika and chikungunya viruses. | zika and chikungunya viruses have caused major epidemics and are transmitted by aedes aegypti and/or aedes albopictus mosquitoes. the "sementis copenhagen vector" (scv) system is a recently developed vaccinia-based, multiplication-defective, vaccine vector technology that allows manufacture in modified cho cells. herein we describe a single-vector construct scv vaccine that encodes the structural polyprotein cassettes of both zika and chikungunya viruses from different loci. a single vaccination ... | 2018 | 29581442 |
| maternal invasion history of aedes aegypti and aedes albopictus into the isthmus of panama: implications for the control of emergent viral disease agents. | despite an increase in dengue outbreaks and the arrival of chikungunya and zika disease in panama, studies on the demographic history of the invasive aedes mosquitoes that are the principle vectors of these diseases are still lacking in this region. here, we assess the genetic diversity of these mosquitoes in order to decipher their invasion histories into the isthmus of panama. dna sequences from the mitochondrial cytochrome c oxidase i gene obtained from 30 localities in 10 provinces confirmed ... | 2018 | 29579112 |
| frequency and intensity of pyrethroid resistance through the cdc bottle bioassay and their association with the frequency of kdr mutations in aedes aegypti (diptera: culicidae) from mexico. | the control of aedes aegypti (l.), the main urban vector that causes arboviral diseases such as dengue, chikungunya and zika, has proved to be a challenge because of a rapid increase in insecticide resistance. therefore, adequate monitoring of insecticide resistance is an essential element in the control of ae. aegypti and the diseases it transmits. we estimated the frequency and intensity (resistance frequency rapid diagnostic test [f-rdt] and resistance intensity rapid diagnostic test [i-rdt]) ... | 2018 | 29575404 |
| characterization of the adult aedes aegypti early midgut peritrophic matrix proteome using lc-ms. | the aedes aegypti mosquito is the principal vector of arboviruses such as dengue, chikungunya, yellow fever, and zika virus. these arboviruses are transmitted during adult female mosquito bloodfeeding. while these viruses must transverse the midgut to replicate, the blood meal must also reach the midgut to be digested, absorbed, or excreted, as aggregation of blood meal metabolites can be toxic to the female mosquito midgut. the midgut peritrophic matrix (pm), a semipermeable extracellular layer ... | 2018 | 29570734 |
| population dynamics of engineered underdominance and killer-rescue gene drives in the control of disease vectors. | a number of different genetics-based vector control methods have been proposed. two approaches currently under development in aedes aegypti mosquitoes are the two-locus engineered underdominance and killer-rescue gene drive systems. each of these is theoretically capable of increasing in frequency within a population, thus spreading associated desirable genetic traits. thus they have gained attention for their potential to aid in the fight against various mosquito-vectored diseases. in the case ... | 2018 | 29570717 |
| treatment of chikungunya chronic arthritis: a systematic review. | chikungunya (chik) is a tropical arbovirus, transmitted by the female mosquito aedes aegypti and aedes albopictus. in brazil, there have been cases reported since 2014. the initial manifestations of this virus are sudden onset high fever, headache, chills, rashes, myalgia and intense joint pain. usually, chik presents the acute and chronic phases, the latter characterized by bilateral polyarthralgia, which can last for months or even years. during this period, autoimmune diseases can be triggere ... | 2018 | 29561944 |
| model-based inference from multiple dose, time course data reveals wolbachia effects on infection profiles of type 1 dengue virus in aedes aegypti. | infection is a complex and dynamic process involving a population of invading microbes, the host and its responses, aimed at controlling the situation. depending on the purpose and level of organization, infection at the organism level can be described by a process as simple as a coin toss, or as complex as a multi-factorial dynamic model; the former, for instance, may be adequate as a component of a population model, while the latter is necessary for a thorough description of the process beginn ... | 2018 | 29558464 |
| mosquito-borne human viral diseases: whyaedes aegypti? | although numerous viruses are transmitted by mosquitoes, four have caused the most human suffering over the centuries and continuing today. these are the viruses causing yellow fever, dengue, chikungunya, and zika fevers. africa is clearly the ancestral home of yellow fever, chikungunya, and zika viruses and likely the dengue virus. several species of mosquitoes, primarily in the genusaedes, have been transmitting these viruses and their direct ancestors among african primates for millennia allo ... | 2018 | 29557341 |
| dengue virus infection inaedes albopictusduring the 2014 autochthonous dengue outbreak in tokyo metropolis, japan. | in 2014 in japan, 162 autochthonous dengue cases were reported for the first time in nearly 70 years. here, we report the results of the detection and isolation of dengue virus (denv) from mosquitoes collected in tokyo metropolis in 2014 and 2015. the phylogenetic relationship among denv isolates from mosquitoes and from patients based on both the entire envelope gene and whole coding sequences was evaluated. herein, 2,298 female and 956 maleaedes albopictusmosquitoes were collected at six suspe ... | 2018 | 29557338 |
| identification of aanat5b as a spermine n-acetyltransferase in the mosquito, aedes aegypti. | mosquitoes transmit a number of diseases in animals and humans, including dengue, chikungunya and zika viruses that affect millions of people each year. controlling the disease-transmitting mosquitoes has proven to be a successful strategy to reduce the viruses transmission. polyamines are required for the life cycle of the rna viruses, chikungunya virus and zika virus, and a depletion of spermidine and spermine in the host via induction of spermine n-acetyltransferase restricts their replicatio ... | 2018 | 29554129 |
| the mixture of cashew nut shell liquid and castor oil results in an efficient larvicide against aedes aegypti that does not alter embryo-fetal development, reproductive performance or dna integrity. | dengue fever, chikungunya fever and zika virus are epidemics in brazil that are transmitted by mosquitoes, such as aedes aegypti or aedes albopictus. the liquid from shells of cashew nuts is attractive for its important biological and therapeutic activities, which include toxicity to mosquitoes of the genus aedes. the present study evaluated the effects of a mixture of surfactants from natural cashew nutshell liquid and castor oil (named talcc-20) on the mortality of larvae and on the reproducti ... | 2018 | 29554095 |
| repellent activity of trig (n-n diethyl benzamide) against man-biting mosquitoes. | a study was conducted to assess efficacy of a new repellent brand trig (15% n-n diethyl benzamide) when compared to deet (20% n-n methyl toluamide). the repellents were tested in laboratory and field. in the laboratory, the repellence was tested on human volunteers, by exposing their repellent-treated arms on starved mosquitoes in cages for 3 minutes at hourly intervals, while counting the landing and probing attempts. anopheles gambiae and aedes aegypti mosquitoes were used. field evaluation wa ... | 2018 | 29552040 |
| functional characterization of mosquito short neuropeptide f receptors. | mosquito blood feeding transiently inhibits sugar- and host seeking through neuropeptide signaling. short neuropeptide f (snpf) is one of the neuromodulators involved in this regulation. here, we identified the genes for the snpf precursor and the snpf receptor in the southern house mosquito, culex quinquefasciatus. comparative analyses are made with the genes of the snpf precursor and receptor from two other important vectors, aedes aegypti and anopheles coluzzii. we functionally characterized ... | 2018 | 29550617 |
| mapping the virome in wild-caught aedes aegypti from cairns and bangkok. | medically important arboviruses such as dengue, zika, and chikungunya viruses are primarily transmitted by the globally distributed mosquito aedes aegypti. increasing evidence suggests that transmission can be influenced by mosquito viromes. herein rna-seq was used to characterize rna metaviromes of wild-caught ae. aegypti from bangkok (thailand) and from cairns (australia). the two mosquito populations showed a high degree of similarity in their viromes. blast searches of assembled contigs sugg ... | 2018 | 29549363 |
| estimating the probability of dengue virus introduction and secondary autochthonous cases in europe. | given the speed of air travel, diseases even with a short viremia such as dengue can be easily exported to dengue naïve areas within 24 hours. we set out to estimate the risk of dengue virus introductions via travelers into europe and number of secondary autochthonous cases as a result of the introduction. we applied mathematical modeling to estimate the number of dengue-viremic air passengers from 16 dengue-endemic countries to 27 european countries, taking into account the incidence of dengue ... | 2018 | 29545610 |
| house screening with insecticide-treated netting provides sustained reductions in domestic populations of aedes aegypti in merida, mexico. | there is a need for effective methods to control aedes aegypti and prevent the transmission of dengue, chikungunya, yellow fever and zika viruses. insecticide treated screening (its) is a promising approach, particularly as it targets adult mosquitoes to reduce human-mosquito contact. | 2018 | 29543805 |
| the seasonal influence of climate and environment on yellow fever transmission across africa. | yellow fever virus (yfv) is a vector-borne flavivirus endemic to africa and latin america. ninety per cent of the global burden occurs in africa where it is primarily transmitted by aedes spp, with aedes aegypti the main vector for urban yellow fever (yf). mosquito life cycle and viral replication in the mosquito are heavily dependent on climate, particularly temperature and rainfall. we aimed to assess whether seasonal variations in climatic factors are associated with the seasonality of yf rep ... | 2018 | 29543798 |
| risk perception and level of knowledge of diseases transmitted by aedes aegypti. | diseases caused by viruses such as dengue, chikungunya and zika are mosquito-borne diseases transmitted by aedes aegypti. we performed a cross-sectional study of healthcare personnel and the general population using questionnaires to identify the level of knowledge, attitudes and practices, and risk perception for dengue, chikungunya and zika. a total of 248 questionnaires were applied, 63.3% to healthcare personnel and 36.7% to the general population. of the healthcare personnel, 53% were men, ... | 2018 | 29538507 |
| dengue virus in aedes aegypti and aedes albopictus in urban areas in the state of rio grande do norte, brazil: importance of virological and entomological surveillance. | vector control remains the sole effective method to prevent dengue virus (denv) transmission, although a vaccine for dengue has recently become available and testing of its efficacy and coverage is being performed in multiple places. entomological surveillance is a key factor in alerting authorities to possible outbreaks, but until now natural denv infection of mosquito populations has been scarcely used as an early warning system to monitor fluctuating prevalence of infected mosquitoes. the pur ... | 2018 | 29534105 |
| chikungunya virus: a rheumatologist's perspective. | chikungunya virus (chikv) is an arthropod-borne alphavirus, transmitted by aedes aegypti and aedes albopictus mosquitoes. it is responsible for a febrile illness, typically accompanied by maculopapular rash and severe, incapacitating arthralgia. the disease, although generally self-limiting, frequently evolves into a long-lasting, debilitating rheumatic disorder, which shares many clinical features with rheumatoid arthritis (ra). the underlying mechanism by which chikv induces persistent arthrit ... | 2018 | 29533749 |
| comparative phylogeography ofaedesmosquitoes and the role of past climatic change for evolution within africa. | the study of demographic processes involved in species diversification and evolution ultimately provides explanations for the complex distribution of biodiversity on earth, indicates regions important for the maintenance and generation of biodiversity, and identifies biological units important for conservation or medical consequence. african and forest biota have both received relatively little attention with regard to understanding their diversification, although one possible mechanism is that ... | 2018 | 29531714 |
| hr38, an ortholog of nr4a family nuclear receptors, mediates 20-hydroxyecdysone regulation of carbohydrate metabolism during mosquito reproduction. | the aedes aegypti mosquito is the principal vector for many dangerous human viral diseases. carbohydrate metabolism (cm) is essential for supplying the energy necessary for host seeking, blood digestion and rapid egg development of this vector insect. the steroid hormone 20-hydroxyecdysone (20e) and the ecdysone receptor (ecr) are important regulators of cm, coordinating it with female reproductive events. we report here that the nr4a nuclear receptor ahr38 plays a critical role in mediating the ... | 2018 | 29526770 |
| jh biosynthesis and hemolymph titers in adult male aedes aegypti mosquitoes. | juvenile hormone (jh) is a major hormonal regulator in insects. in aedes aegypti females, jh signals the completion of the ecdysis to the adult stage and initiates reproductive processes. although the regulation of jh synthesis and titer in ae. aegypti females has been extensively studied, relatively little is known about changes of jh synthesis and titers in male mosquitoes, as well as on the roles of jh controlling male reproductive biology. a better understanding of male mosquito reproductive ... | 2018 | 29526769 |
| natural variation in resistance to virus infection in dipteran insects. | the power and ease ofdrosophilagenetics and the medical relevance of mosquito-transmitted viruses have made dipterans important model organisms in antiviral immunology. studies of virus-host interactions at the molecular and population levels have illuminated determinants of resistance to virus infection. here, we review the sources and nature of variation in antiviral immunity and virus susceptibility in model dipteran insects, specifically the fruit flydrosophila melanogasterand vector mosquit ... | 2018 | 29522475 |
| mosquito pornoscopy: observation and interruption of aedes aegypti copulation to determine female polyandric event and mixed progeny. | ades aegypti is the most important arbovirus vector in the world, and new strategies are under evaluation. biological studies mentioning the occurrence of a second mate in aedes aegypti can interfere with vector control program planning, which involves male mosquito release technique. this study presents different experiments to show the occurrence of mixed progeny. mixed male crosses (using a combination of different type of males in confinement with virgin females) showed no polyandric female. ... | 2018 | 29518112 |
| update: noncongenital zika virus disease cases - 50 u.s. states and the district of columbia, 2016. | zika virus is a flavivirus primarily transmitted to humans by aedes aegypti mosquitoes (1). zika virus infections also have been documented through intrauterine transmission resulting in congenital infection; intrapartum transmission from a viremic mother to her newborn; sexual transmission; blood transfusion; and laboratory exposure (1-3). most zika virus infections are asymptomatic or result in mild clinical illness, characterized by acute onset of fever, maculopapular rash, arthralgia, or non ... | 2018 | 29518067 |
| comparative oviposition site selection in containers by aedes aegypti and aedes albopictus (diptera: culicidae) from florida. | invasive container mosquito species aedes aegypti (l.) and ae. albopictus (skuse) frequently co-occur in nature where they are typically segregated spatially by distinctive macrohabitat preferences that may select for different oviposition strategies. in a standard cage environment, we compared oviposition site selection by individual gravid females of these species exposed to variable numbers of water-holding cups and the presence or absence of a rugose wettable container lining. offered plasti ... | 2018 | 29514300 |
| building infestation index for aedes aegypti and occurrence of dengue fever in the municipality of foz do iguaçu, paraná, brazil, from 2001 to 2016. | the building infestation index (bii) uses the rapid assay of the larval index for aedes aegypti (liraa) to express the relationship between positive and surveyed properties. we evaluated liraa and the relationship between the bii and climate variables for dengue cases in foz do iguaçu municipality, paraná. | 2018 | 29513847 |
| impacts of diurnal temperature and larval density on aquatic development of aedes aegypti. | the increasing range of aedes aegypti, vector for zika, dengue, chikungunya, and other viruses, has brought attention to the need to understand the population and transmission dynamics of this mosquito. it is well understood that environmental factors and breeding site characteristics play a role in organismal development and the potential to transmit pathogens. in this study, we observe the impact of larval density in combination with diurnal temperature on the time to pupation, emergence, and ... | 2018 | 29513751 |
| zika virus epidemiology in bolivia: a seroprevalence study in volunteer blood donors. | zika virus (zikv), was widely reported in latin america and has been associated with neuropathologies, as microcephaly, but only few seroprevalence studies have been published to date. our objective was to determine the seroprevalence amongst bolivian blood donors and estimate the future potential circulation of the virus. | 2018 | 29513667 |
| occurrence of sweet refuse at disposal sites: rainwater retention capacity and potential breeding opportunities for aedes aegypti. | nectar is the staple diet of adult mosquitoes in the wild, but its availability is inconsistent and can be affected by rainfall. in urban centers, aedes vectors commonly use man-made containers as their major habitat; however, they can colonize any items replenished by rainfall. garbage output has increased significantly in recent years, at a time when collection frequency is reducing. such garbage usually includes organic components, some of which are sweet and can be fed upon by other animals ... | 2018 | 29512008 |
| swift fabrication of ag nanostructures using a colloidal solution of holostemma ada-kodien (apocynaceae) - antibiofilm potential, insecticidal activity against mosquitoes and non-target impact on water bugs. | recent research in entomology and parasitology focused on the efficacy of green fabricated nanomaterials as novel insecticides. in this study, we synthesized poly-dispersed and stable silver nanoparticles (agnps) using the leaf extract of holostemma ada-kodien. the nanostructures were characterized by ultraviolet-visible spectroscopy, fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, energy dispersive x-ray, and x-ray diffraction analysis. t ... | 2018 | 29510358 |
| salivary factor ltrin from aedes aegypti facilitates the transmission of zika virus by interfering with the lymphotoxin-β receptor. | pathogens have co-evolved with mosquitoes to optimize transmission to hosts. mosquito salivary-gland extract is known to modulate host immune responses and facilitate pathogen transmission, but the underlying molecular mechanisms of this have remained unknown. in this study, we identified and characterized a prominent 15-kilodalton protein, ltrin, obtained from the salivary glands of the mosquito aedes aegypti. ltrin expression was upregulated in blood-fed mosquitoes, and ltrin facilitated the t ... | 2018 | 29507355 |
| transovarial transmission of dengue 1 virus in aedes aegypti larvae: real-time pcr analysis in a brazilian city with high mosquito population density. | transovarial transmission is among the reported factors able to influence environmental maintenance of dengue virus (denv). endemic areas with active transmission of dengue are suitable for studying transovarial transmission. brazil is a country where dengue is endemic and where denv-1 is the most common disease-related virus serotype. this study aimed to identify transovarial transmission of denv-1 in aedes aegypti larvae by reverse-transcriptase nested real-time polymerase chain reaction. betw ... | 2018 | 29505732 |
| the non-canonical notch signaling is essential for the control of fertility in aedes aegypti. | the notch signaling pathway is a highly evolutionarily-conserved cell-cell signaling pathway that regulates many events during development. it plays a pivotal role in the regulation of fundamental cellular processes, such as cell proliferation, stem cell maintenance, and differentiation during embryonic and adult development. however, functions of notch signaling in aedes aegypti, the major mosquito vector for dengue, are largely unknown. in this study, we identified a unique feature of a. aegyp ... | 2018 | 29505577 |
| altered vector competence in an experimental mosquito-mouse transmission model of zika infection. | few animal models of zika virus (zikv) infection have incorporated arthropod-borne transmission. here, we establish an aedes aegypti mosquito model of zikv infection of mice, and demonstrate altered vector competency among three strains, (orlando, orl, ho chi minh, hcm, and patilas, pat). all strains acquired zikv in their midguts after a blood meal from infected mice, but zikv transmission only occurred in mice fed upon by hcm, and to a lesser extent pat, but not orl, mosquitoes. this defect in ... | 2018 | 29505571 |
| dengue knowledge in indoor dengue patients from low socioeconomic class; aetiology, symptoms, mode of transmission and prevention. | dengue fever has emerged as an emerging public health issue during last decade bearing significant morbidity and economic burden particularly in third world countries. current study aims to assess various domains of knowledge of indoor dengue patients.. | 2018 | 29504327 |
| resistance of aedes aegypti (diptera: culicidae) populations to deltamethrin, permethrin, and temephos in cambodia. | dengue fever is a major public health concern, including 185,000 annual cases in cambodia. aedes aegypti is the primary vector for dengue transmission and is targeted with insecticide treatments. this study characterized the insecticide resistance status of ae aegypti from rural and urban locations. the susceptibility to temephos, permethrin, and deltamethrin of ae aegypti was evaluated in accordance with world health organization instructions. all the field populations showed lower mortality ra ... | 2018 | 29502428 |
| effects of climate change on the spread of zika virus: a public health threat. | zika is a vector-borne viral disease transmitted to humans primarily by aedes aegypti mosquitoes. the increased climate instability has contributed to the emergence of infections carried by mosquitoes like dengue, chikungunya and zika. while infection with the zika virus is not new, the recent epidemic of microcephaly in brazil and other countries in south america resulting from the infection of pregnant women with the zika virus raise a number of serious public health concerns. these include th ... | 2018 | 29500926 |
| bacterial microbiota of aedes aegypti mosquito larvae is altered by intoxication with bacillus thuringiensis israelensis. | insect microbiota is a dynamic microbial community that can actively participate in defense against pathogens. bacillus thuringiensis (bt) is a natural entomopathogen widely used as a bioinsecticide for pest control. although bt's mode of action has been extensively studied, whether the presence of microbiota is mandatory for bt to effectively kill the insect is still under debate. an association between a higher tolerance and a modified microbiota was already evidenced but a critical point rema ... | 2018 | 29499735 |
| full-genome dengue virus sequencing in mosquito saliva shows lack of convergent positive selection during transmission byaedes aegypti. | like other pathogens with high mutation and replication rates, within-host dengue virus (denv) populations evolve during infection of their main mosquito vector,aedes aegypti. within-host denv evolution during transmission provides opportunities for adaptation and emergence of novel virus variants. recent studies of denv genetic diversity failed to detect convergent evolution of adaptive mutations in mosquito tissues such as midgut and salivary glands, suggesting that convergent positive selecti ... | 2017 | 29497564 |
| anti-diuretic action of a capa neuropeptide against a subset of diuretic hormones in the disease vector aedes aegypti. | the mosquito aedes aegypti is a vector responsible for transmitting various pathogens to humans, and their prominence as chief vectors of human disease is largely due to their anthropophilic blood feeding behaviour. larval stage mosquitoes must deal with the potential dilution of their haemolymph in freshwater, whereas the haematophagus a. aegypti female faces the challenge of excess ion and water intake after a blood meal. the excretory system, composed of the malpighian tubules (mts) and hindg ... | 2018 | 29496779 |
| wolbachia-mediated virus blocking in mosquito cells is dependent on xrn1-mediated viral rna degradation and influenced by viral replication rate. | wolbachia is currently being developed as a novel tool to block the transmission of dengue viruses (denv) by aedes aegypti. a number of mechanisms have been proposed to explain the denv-blocking phenotype in mosquitoes, including competition for fatty acids like cholesterol, manipulation of host mirnas and upregulation of innate immune pathways in the mosquito. we examined the various stages in the denv infection process to better understand the mechanism of wolbachia-mediated virus blocking (wm ... | 2018 | 29494679 |
| dengue in araraquara, state of são paulo: epidemiology, climate and aedes aegypti infestation. | objective to describe the epidemiology of dengue in a medium-sized city in the state of são paulo. methods data, such as circulating serotypes, severe cases and deaths, age group, sex, among others, were obtained on reported and confirmed dengue cases in araraquara, state of são paulo, between 1991 and 2015. climatic and infestation data were also analyzed. these variables were evaluated descriptively, using statistical measures such as frequencies, averages, minimum and maximum. dengue incidenc ... | 2018 | 29489994 |
| [zika: probability of establishment of its vector, aedes aegypti, in chile]. | the zika virus has raised world alarm in recent years, representing a major public health problem. in this study we evaluated the potential risk of exposure to zika virus in chile, associated with the probability of establishment of the vector aedes aegypti in the country. niche modelling techniques were used to project the bioclimatic requirements of the vector (global niches), identifying zones of high suitability for the species within the country. then, the potential distribution of the vect ... | 2017 | 29488548 |
| first evidence of vertical infection of dengue virus 2 in aedes aegypti mosquitoes from sinaloa, mexico. | fourteen pools of aedes aegypti larvae collected within the urban area of culiacán, sinaloa, were analyzed by rt-pcr. the results demonstrate, for the first time, the vertical infection of serotype-2 dengue virus (denv-2) in sinaloa, mexico, suggesting that ae. aegypti acts as a natural reservoir of denv-2 in this region. | 2018 | 29485942 |
| an overview of mosquito vectors of zika virus. | the mosquito-borne arbovirus zika virus (zikv, flavivirus, flaviviridae), has caused an outbreak impressive by its magnitude and rapid spread. first detected in uganda in africa in 1947, from where it spread to asia in the 1960s, it emerged in 2007 on the yap island in micronesia and hit most islands in the pacific region in 2013. subsequently, zikv was detected in the caribbean, and central and south america in 2015, and reached north america in 2016. although zikv infections are in general asy ... | 2018 | 29481868 |
| hypericum japonicum: a double-headed sword to combat vector control and cancer. | mosquito control with naturally derived herbal insecticides has gained much momentum, with the increased insecticide resistance of vectors and the multiple infectious diseases spread by them. yet, recent studies also suggest that mosquitoes could probably transmit some cancerous cells or cancer-causing viruses from one individual to another between their blood meals. the current research thus focused on the screening and characterization of novel plants with both mosquitocidal and anticancerous ... | 2018 | 29476319 |
| mosquitocidal activity of a naturally occurring isochroman and synthetic analogs from the plant pathogenic fungus, diaporthe eres against aedes aegypti (diptera: culicidae). | the culture filtrate of a plant pathogenic fungus that infects english ivy (hedera helix l., araliaceae) was investigated for mosquitocidal constituents by bioassay-guided isolation. the fungus responsible for pathogenic effects on the plant h. helix has been identified as diaporthe eres nitschke by molecular techniques. the mosquito adulticidal constituent in the culture filtrate was identified as 3,4-dihydro-8-hydroxy-3,5-dimethylisocoumarin (1) by spectroscopic techniques. laboratory bioassay ... | 2018 | 29474636 |
| comparative analysis of major mosquito vectors response to seed-derived essential oil and seed pod-derived extract from acacia nilotica. | botanical metabolites are increasingly realized as potential replacements to chemical insecticides. in the present study, acacia nilotica seed essential oil and seed pod solvent extracts were tested for bioefficacy against three important types of mosquitoes. mortality was recorded 24 h post-treatment, while smoke toxicity of adult mosquitoes was recorded at 10 min intervals for 40 min. seed pod powder was extracted with different solvents and hydrodistilled seed oil chemical constituents were d ... | 2018 | 29473901 |
| vector competence of selected north americananophelesandculexmosquitoes for zika virus. | zika virus (zikv) is a vector-borne flavivirus that has caused recent outbreaks associated with serious disease in infants and newborns in the americas.aedesmosquitoes are the primary vectors for zikv, but little is known about the diversity of mosquitoes that can transmit zikv in north america. we chose three abundant north american mosquito species (anopheles freeborni,anopheles quadrimaculatus, andculex tarsalis) and one known vector species (aedes aegypti), fed them blood meals supplemented ... | 2018 | 29472998 |
| in tune with nature: wolbachia does not prevent pre-copula acoustic communication in aedes aegypti. | mosquito-borne diseases are rapidly spreading to vast territories, putting at risk most of the world's population. a key player in this scenario is aedes aegypti, a hematophagous species which hosts and transmits viruses causing dengue and other serious illnesses. since vector control strategies relying only on insecticides have proven unsustainable, an alternative method involving the release of wolbachia-harboring individuals has emerged. its successful implementation vastly depends on how fit ... | 2018 | 29471864 |
| socioeconomic and human behavioral factors associated with aedes aegypti (diptera: culicidae) immature habitat in tucson, az. | aedes aegypti (l.; diptera: culicidae) has been established in the southwestern united states for several decades, but relationships between humans and mosquitoes in this arid region are not well-characterized. in august 2012, the outdoor premises of 355 houses within 20 neighborhoods in tucson, arizona were surveyed for containers that could provide larval habitat for ae. aegypti mosquitoes. at the same time, a knowledge, attitudes and practices (kap) questionnaire was administered to a residen ... | 2018 | 29471405 |
| dengue viruses and promising envelope protein domain iii-based vaccines. | dengue viruses are emerging mosquito-borne pathogens belonging to flaviviridae family which are transmitted to humans via the bites of infected mosquitoes aedes aegypti and aedes albopictus. because of the wide distribution of these mosquito vectors, more than 2.5 billion people are approximately at risk of dengue infection. dengue viruses cause dengue fever and severe life-threatening illnesses as well as dengue hemorrhagic fever and dengue shock syndrome. all four serotypes of dengue virus can ... | 2018 | 29470620 |
| potential occurrence of zika from subtropical to temperate argentina considering the basic reproduction number (r0). | to assess the potential occurrence of zika transmission throughout argentina by the mosquito aedes aegypti considering the basic reproduction number (r0). | 2018 | 29466517 |
| infectivity of chordodes nobilii larvae (gordiida: nematomorpha). | the gordiids are freshwater representatives of the parasite phylum nematomorpha that function asa link between aquatic and terrestrial ecosystems. in recent years, different ecotoxicologic studies have beenmade with the south-american gordiid species, chordodes nobilii, that have demonstrated the capacity of thisgroup to act as a bioindicator of contamination. despite the gordiida’s ecologic relevance, further studies arestill needed to elucidate different aspects of the biology of the class, an ... | 2017 | 29465953 |
| [updating the larval habitats of aedes aegypti (diptera: culicidae) in camagüey, cuba]. | several illnesses of vectorial origin have a great medical and veterinary relevance, due to the adaptations developed by the species involved in their transmission. to support preventive programs with updated ecological information of ae. aegypti populations, an entomological survey was carried out in three health areas of camagüey, cuba, during low and high rain seasons of 2013. for this, we assessed the type and number of positive containers, quantified larvae and pupae in positive containers, ... | 2016 | 29465911 |
| alterations of mitochondrial electron transport chain and oxidative stress induced by alkaloid-like α-aminonitriles on aedes aegypti larvae. | aedes aegypti mosquitoes are responsible for dengue, chikungunya, and zika virus transmission in tropical and subtropical areas around the world. due to the absence of vaccines or antiviral drugs for human treatment, the majority of control strategies are targeted at ae. aegypti elimination. our research on mosquito control insecticidal agents has previously shown that the alkaloid girgensohnine and its analogues (α-aminonitriles) present in vitro acetylcholinesterase inhibition and in vivo inse ... | 2018 | 29463410 |
| effectiveness of a field trap barrier system for controlling aedes albopictus: a "removal trapping" strategy. | aedes aegypti and aedes albopictus are the main vectors for the transmission of several viral pathogens, in particular, dengue, zika and chikungunya. in the absence of vaccines and treatment, control of aedes mosquitoes is the only means of keeping these diseases in check. aedes control is difficult, and it is, therefore, necessary to evaluate the efficacy of novel control methods, particularly those targeting adult and exophilic ae. albopictus populations. | 2018 | 29463300 |
| using adult aedes aegypti females to predict areas at risk for dengue transmission: a spatial case-control study. | traditional indices for measuring dengue fever risk in a given area are based on the immature forms of the vector (larvae and pupae surveys). however, this is inefficient because only adult female mosquitoes actually transmit the virus. based on these assumptions, our objective was to evaluate the association between an entomological index obtained from adult mosquito traps and the occurrence of dengue in a hyperendemic area. additionally, we compared its cost to that of the breteau index (bi). | 2018 | 29462598 |
| seasonal distribution and container preference ratio of the dengue fever vector (aedes aegypti, diptera: culicidae) in rawalpindi, pakistan. | aedes aegypti (l.) and aedes albopictus (skuse) are known vectors of dengue, chikungunya, and other pathogens; however, their ecology and role in virus transmission has not been well studied in pakistan. here, we report on an intensive survey of potential breeding sites of ae. aegypti in rawalpindi, punjab province, pakistan. the study continued for 11 mo and was divided into three seasons: january to june (pre-monsoon), july to september (monsoon), and october-november (post-monsoon). larval mo ... | 2018 | 29462424 |
| host plant forensics and olfactory-based detection in afro-tropical mosquito disease vectors. | the global spread of vector-borne diseases remains a worrying public health threat, raising the need for development of new combat strategies for vector control. knowledge of vector ecology can be exploited in this regard, including plant feeding; a critical resource that mosquitoes of both sexes rely on for survival and other metabolic processes. however, the identity of plant species mosquitoes feed on in nature remains largely unknown. by testing the hypothesis about selectivity in plant feed ... | 2018 | 29462150 |
| improving vector-borne pathogen surveillance: a laboratory-based study exploring the potential to detect dengue virus and malaria parasites in mosquito saliva. | vector-borne pathogen surveillance programmes typically rely on the collection of large numbers of potential vectors followed by screening protocols focused on detecting pathogens in the arthropods. these processes are laborious, time consuming, expensive, and require screening of large numbers of samples. to streamline the surveillance process, increase sample throughput, and improve cost-effectiveness, a method to detect dengue virus and malaria parasites (plasmodium falciparum) by leveraging ... | 2018 | 29460859 |
| larvicidal activity of selected plant extracts and their combination against the mosquito vectors culex quinquefasciatus and aedes aegypti. | in order to develop an environment-friendly botanical mosquito larvicide alternative to the chemical larvicides, extracts were made from the leaves of hyptis suaveolens, lantana camara, nerium oleander, and tecoma stans with three organic solvents such as methanol (me), chloroform (ch), and petroleum ether (pe) using a soxhlet extractor. the plant extracts were screened for larvicidal activity individually and in combination against the larvae of aedes aegypti and culex quinquefasciatus as per w ... | 2018 | 29460245 |
| synergistic effect of entomopathogenic fungus fusarium oxysporum extract in combination with temephos against three major mosquito vectors. | mosquito control using chemical insecticides is facing a major challenge due to development of insecticide resistance. improving the efficiency of existing insecticides using synergistic secondary metabolites of biological origin is increasingly being researched. herein, we evaluated the toxicity of fusarium oxysporum extract alone and in binary combinations with temephos, on larvae and pupae of anopheles stephensi, aedes aegypti and culex quinquefaciatus. f. oxysporum extract was characterized ... | 2018 | 29457957 |
| environmental factors can influence dengue reported cases. | global climate changes directly affect the natural environment and contribute to an increase in the transmission of diseases by vectors. among these diseases, dengue is at the top of the list. the aim of our study was to understand the consequences of temporal variability of air temperature in the occurrence of dengue in an area comprising seven municipalities of the greater são paulo. | 2017 | 29451659 |
| entomological and epidemiological aspects of dengue epidemics in fortaleza, ceará, brazil, 2001-2012. | to characterize the entomological and epidemiological aspects of dengue epidemics occurred in fortaleza, ceará, brazil, from 2001 to 2012. | 2018 | 29451615 |
| analysis of cluster-randomized test-negative designs: cluster-level methods. | intervention trials of vector control methods often require community level randomization with appropriate inferential methods. for many interventions, the possibility of confounding due to the effects of health-care seeking behavior on disease ascertainment remains a concern. the test-negative design, a variant of the case-control method, was introduced to mitigate this issue in the assessment of the efficacy of influenza vaccination (measured at an individual level) on influenza infection. her ... | 2019 | 29447357 |
| dynamic remodeling of lipids coincides with dengue virus replication in the midgut of aedes aegypti mosquitoes. | we describe the first comprehensive analysis of the midgut metabolome of aedes aegypti, the primary mosquito vector for arboviruses such as dengue, zika, chikungunya and yellow fever viruses. transmission of these viruses depends on their ability to infect, replicate and disseminate from several tissues in the mosquito vector. the metabolic environments within these tissues play crucial roles in these processes. since these viruses are enveloped, viral replication, assembly and release occur on ... | 2018 | 29447265 |
| current and future distribution of aedes aegypti and aedes albopictus (diptera: culicidae) in who eastern mediterranean region. | aedes-borne diseases as dengue, zika, chikungunya and yellow fever are an emerging problem worldwide, being transmitted by aedes aegypti and aedes albopictus. lack of up to date information about the distribution of aedes species hampers surveillance and control. global databases have been compiled but these did not capture data in the who eastern mediterranean region (emr), and any models built using these datasets fail to identify highly suitable areas where one or both species may occur. the ... | 2018 | 29444675 |
| mosquitoes of northwestern uganda. | despite evidence of arbovirus activity in northwestern uganda (west nile sub-region), there is very limited information on the mosquito fauna of this region. the only published study reported 52 mosquito species in northwestern uganda but this study took place in 1950 and the information has not been updated for more than 60 yr. in january and june 2011, co2 baited-light traps were used to collect 49,231 mosquitoes from four different locations, paraa (9,487), chobe (20,025), sunguru (759), and ... | 2018 | 29444287 |
| a point mutation v419l in the sodium channel gene from natural populations of aedes aegypti is involved in resistance to λ-cyhalothrin in colombia. | resistance to pyrethroids in mosquitoes is mainly caused by target site insensitivity known as knockdown resistance (kdr). in this work, we examined the point mutations present in portions of domains i, ii, iii, and iv of the sodium channel gene in aedes aegypti mosquitoes from three colombian municipalities. a partial region coding for the sodium channel gene from resistant mosquitoes was sequenced, and a simple allele-specific pcr-based assay (as-pcr) was used to analyze mutations at the popul ... | 2018 | 29443870 |
| analysis of peptide ligand specificity of different insect adipokinetic hormone receptors. | adipokinetic hormone (akh) is a highly researched insect neuropeptide that induces the mobilization of carbohydrates and lipids from the fat body at times of high physical activity, such as flight and locomotion. as a naturally occurring ligand, akh has undergone quite a number of amino acid changes throughout evolution, and in some insect species multiple akhs are present. akh acts by binding to a rhodopsin-like g protein-coupled receptor, which is related to the vertebrate gonadotropin-releasi ... | 2018 | 29439466 |
| modeling the spread of the zika virus using topological data analysis. | zika virus (zikv), a disease spread primarily through the aedes aegypti mosquito, was identified in brazil in 2015 and was declared a global health emergency by the world health organization (who). epidemiologists often use common state-level attributes such as population density and temperature to determine the spread of disease. by applying techniques from topological data analysis, we believe that epidemiologists will be able to better predict how zikv will spread. we use the vietoris-rips fi ... | 2018 | 29438377 |
| functional characterization and quantitative expression analysis of two gnrh-related peptide receptors in the mosquito, aedes aegypti. | to cope with stressful events such as flight, organisms have evolved various regulatory mechanisms, often involving control by endocrine-derived factors. in insects, two stress-related factors include the gonadotropin-releasing hormone-related peptides adipokinetic hormone (akh) and corazonin (crz). akh is a pleiotropic hormone best known as a substrate liberator of proteins, lipids, and carbohydrates. although a universal function has not yet been elucidated, crz has been shown to have roles in ... | 2018 | 29432729 |
| the impact of insecticide applications on the dynamics of resistance: the case of four aedes aegypti populations from different brazilian regions. | in the tropics, the utilization of insecticides is still an important strategy for controlling aedes aegypti, the principle vector of dengue, chikungunya and zika viruses. however, increasing insecticide resistance in ae. aegypti populations might hinder insecticide efficacy on a long-term basis. it will be important to understand the dynamics and evolution of insecticide resistance by assessing its frequency and the mechanisms by which it occurs. | 2018 | 29432488 |
| history dependence in insect flight decisions during odor tracking. | natural decision-making often involves extended decision sequences in response to variable stimuli with complex structure. as an example, many animals follow odor plumes to locate food sources or mates, but turbulence breaks up the advected odor signal into intermittent filaments and puffs. this scenario provides an opportunity to ask how animals use sparse, instantaneous, and stochastic signal encounters to generate goal-oriented behavioral sequences. here we examined the trajectories of flying ... | 2018 | 29432454 |
| carica papaya (papaya) latex: a new paradigm to combat against dengue and filariasis vectors aedes aegypti and culex quinquefasciatus (diptera: culicidae). | this study manifests the larvicidal efficacy of carica papaya latex extract and silver nanoparticles (cpagnps) synthesized using latex, against developing immature juveniles of aedes aegypti and culex quinquefasciatus. briefly, the latex was collected and fractioned with different solvents such as chloroform, methanol and aqueously. the obtained crude extracts were subjected to larvicidal activity in the dose-dependent method. after 24 h, the mortality rate was calculated and statistically analy ... | 2018 | 29430347 |
| optimal control approach for establishing wmelpop wolbachia infection among wild aedes aegypti populations. | wolbachia-based biocontrol has recently emerged as a potential method for prevention and control of dengue and other vector-borne diseases. major vector species, such as aedes aegypti females, when deliberately infected with wolbachia become less capable of getting viral infections and transmitting the virus to human hosts. in this paper, we propose an explicit sex-structured population model that describes an interaction of uninfected (wild) male and female mosquitoes and those deliberately inf ... | 2018 | 29429122 |
| a natural agonist of mosquito trpa1 from the medicinal plant cinnamosma fragrans that is toxic, antifeedant, and repellent to the yellow fever mosquito aedes aegypti. | plants produce various secondary metabolites that offer a potential source of novel insecticides and repellents for the control of mosquito vectors. plants of the genus cinnamosma are endemic to, and widely-distributed throughout, the island of madagascar. the barks of these species are commonly used in traditional medicines for treating a wide range of maladies. the therapeutic nature of the bark is thought to be associated with its enrichment of pungent drimane sesquiterpenes, which elicit ant ... | 2018 | 29425195 |
| integrated vector control of aedes aegypti mosquitoes around target houses. | the developing fetuses of pregnant women are at high risk of developing serious birth defects following zika virus infections. we applied an integrated vector control (ivc) approach using source reduction, larviciding, and mass trapping with non-insecticidal sticky traps to protect targeted houses by reducing the density of female aedes aegypti mosquitoes. | 2018 | 29422087 |
| evidence for chikungunya and dengue transmission in quelimane, mozambique: results from an investigation of a potential outbreak of chikungunya virus. | in january 2016, health authorities from zambézia province, mozambique reported the detection of some patients presenting with fever, arthralgia, and a positive result for chikungunya in an igm-based rapid diagnostic test (rdt). we initiated a study to investigate a potential chikungunya outbreak in the city of quelimane. | 2018 | 29415070 |
| re-emergence of aedes aegypti in egypt. | 2018 | 29412959 |