Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [oxygen consumption and oxidation of inferior fatty acids of the kidneys in experimental turbid swelling]. | 1954 | 13172050 | |
| [effect of antibiotics on corynebacterium diphtheriae and on corynebacterium diphtheriae infection. ii. effect of streptomycin on corynebacterium diphtheriae and on corynebacterium diphtheriae infection]. | 1953 | 13165057 | |
| [quantitative variations of cytochrome c in the liver and myocardium in experimental diphtherial intoxication]. | 1953 | 13160212 | |
| [content of succinic dehydrogenase and of adenosintriphosphatase in the liver and myocardium in experimental diphtherial intoxication]. | 1953 | 13160211 | |
| [effect of vitamin k on oxygen consumption by myocardium of rabbit in the presence of diphtherial toxin]. | 1954 | 13160167 | |
| [serological characteristics of corynebacterium diphtheriae and their relation to clinical and epidemiological aspects of diphtheria]. | 1954 | 13157585 | |
| [improvement of efficient bacteriological diagnosis of diphtheria by using enrichment media]. | 1954 | 13156593 | |
| [first observations on the disinfection of carriers of corynebacterium diphtheriae with 5,7-dichloro-8-hydroxyquinaldine]. | 1953 | 13156392 | |
| some observations on the nature of the antigens in the cell wall of corynebacterium diphtheriae. | 1954 | 13149737 | |
| [histopathologic changes in the organs due to corynebacterium diphtheriae alone and with other bacteria]. | 1954 | 13143951 | |
| [correlation between morphological characteristics and sensitivity to bacteriophages in two varieties of corynebacterium diphtheriae type gravis]. | 1953 | 13141601 | |
| [sensitivity of loeffler's bacillus to various antibiotics]. | 1953 | 13141410 | |
| [chemical composition of certain lipid fractions of corynebacterium diphtheriae]. | 1953 | 13140372 | |
| [lethal and necrotizing toxins in bouillon cultures of diphtheria bacilli]. | 1953 | 13137255 | |
| [enrichment of diphtheria bacteria in liquid culture media]. | 1953 | 13137232 | |
| [evaluation slide method of determination of virulence of corynebacterium diphtheriae]. | 1953 | 13134367 | |
| [effect of antibiotics on corynebacterium diphtheriae and on its infection; effect of synthomycetin and of levomycetin on corynebacterium diphtheriae]. | 1953 | 13132537 | |
| phage-host relationships in nontoxigenic and toxigenic diphtheria bacilli. | 1954 | 13129217 | |
| [diphtherial carriage in dental caries]. | 1953 | 13127407 | |
| [culture medium for corynebacterium diphtheriae]. | 1953 | 13111657 | |
| further studies of tellurite plating media for corynebacterium diphtheriae. | 1953 | 13104705 | |
| [the toxinogenesis test in vitro for corynebacterium diphtheriae]. | 1953 | 13101451 | |
| [studies on diphtheria. i. classification strains isolated in chile]. | 1952 | 13100857 | |
| [treatment of neural infections with rd preparation]. | 1953 | 13097794 | |
| studies on the conditions for diphtheria toxin production. 1. influences of the nacl and fe content of the culture medium on the pattern of toxin production. | 1952 | 13097702 | |
| [the tricarboxylic acid cycle in the metabolism of corynebacterium diphtheriae]. | 1953 | 13095434 | |
| the mechanism of the effect of iron and cobalt on the production of toxin by corynebacterium diphtheriae. | 1953 | 13093696 | |
| [effect of antibiotics on diphtheria bacteria in vitro]. | 1953 | 13093479 | |
| [differentiation of corynebacterium diphtheriae from hofman-wellenhof's corynebacterium pseudodiphthericum by the detection of gas in a dextrose-urea tube]. | 1953 | 13091064 | |
| synthesis of components of the vitamin b group by corynebacterium diphtheriae. | 1953 | 13087252 | |
| evidence for the induced nature of the change from nontoxigenicity to toxigenicity in corynebacterium diphtheriae as a result of exposure to specific bacteriophage. | 1953 | 13084557 | |
| a study of the application of standard phage techniques to the host-phage system of corynebacterium diphtheriae. | 1953 | 13084556 | |
| [bound lipids of corynebacterium diphtheriae]. | 1952 | 13081619 | |
| [existence of the so-called karyoid system in corynebacterium diphtheriae]. | 1953 | 13079153 | |
| [type classification of corynebacterium diphtheriae, stability of the various types and their pathological and epidemiological significance]. | 1953 | 13076882 | |
| [structure of bacterial cell. iii. protoplasmic inclusions and method of staining of metachromatic granulations]. | 1953 | 13071073 | |
| [chemical structure of an unsaturated mycolic acid isolated from corynebacterium diphtheriae]. | 1953 | 13066470 | |
| [clinical and bacteriological aspects of atypical diphtheria]. | 1953 | 13054441 | |
| on the formation of diphtheria toxin in saliva by c. diphtheriae. | 1953 | 13051120 | |
| the relation of bacteriophage to the change of corynebacterium diphtheriae from avirulence to virulence. | 1953 | 13048666 | |
| [comparative tests on toxin production by strains of corynebacterium diphtheriae]. | 1952 | 13043328 | |
| [comparative study on bacteriological varieties and on clinical picture produced by 25 strains of corynebacterium diphtheriae]. | 1952 | 13041758 | |
| anomalous toxin produced by corynebacterium diphtheriae. | 1952 | 13040889 | |
| [study of diphtheric toxinogenesis; suppression of inhibiting action of iron by aeration and agitation of cultures]. | 1952 | 13033306 | |
| bacteriophage and the toxigenicity of corynebacterium diphtheriae. | 1953 | 13030876 | |
| diphtheria bacteriophages and their relation to the development of bacterial variants. | 1952 | 13022924 | |
| [release of bacteriophage by lysogenic strains of corynebacterium diphtheriae under the effect of ultraviolet rays]. | 1952 | 13020274 | |
| [serological investigations on corynebacterium diptheriae. ii]. | 1952 | 13015969 | |
| [types of diphtheria bacilli found in |lodz in 1951]. | 1952 | 13012821 | |
| [typing of diphtheria bacilli in the bydgoszcz district and significance of types in the course of diphtheria]. | 1952 | 13012820 | |
| [the biology of aerobic bacteria in the fertilized chicken egg. i. culture of corynebacterium diphtheriae and the effects of diphtheria toxin on the fertilized chick embryo]. | 1952 | 13006960 | |
| [studies on listerella and corynebacterium in animals]. | 1952 | 13001998 | |
| the oxidation of acetone by a soil diphtheroid. | 1952 | 12999694 | |
| [activity in vitro of some glycols on c. diphtheriae]. | 1952 | 12994626 | |
| [types of corynebacterium diphtheriae and their clinical significance]. | 1952 | 12989788 | |
| [research on pleomorphism from urethane in corynebacterium diphtheriae]. | 1952 | 12977976 | |
| [recently proposed culture media for enrichment and isolation of c. diphtheriae]. | 1952 | 12977962 | |
| electrophoretic and diffusion measurements on cell wall oligosaccharides from corynebacterium diptheriae. | 1952 | 12977776 | |
| the nature of the cell wall of corynebacterium diphtheriae. isolation of an oligosaccharide. | 1952 | 12977775 | |
| influence of stannous chloride on the adhesive properties of corynebacterium diphtheriae strains. | stannous ion, as a chloride salt, influenced on the survival and adhesive properties of two toxigenic corynebacterium diphtheriae of the sucrose-fermenting (241 strain) and non-sucrose-fermenting (cdc-e8392 strain) biotypes. differences in survival fractions suggested differences in susceptibility of strains to bactericidal effect of stannous chloride (sncl2). a number of 0.3% bacterial cells of 241 strain and 0.02% of cdc-e8392 strain survived after 220 micro l ml(-1) sncl2 treatment. results o ... | 2003 | 12964050 |
| [persistence of circulation of corynebacterium diphtheriae non-toxigenic strains and low prevalence of carriers in a sample of children vaccinated against diphtheria]. | this study was carried out with the aim to investigate the presence of carriers of diphtheria bacillus in a sample of 1970 healthy children, 6-14 years aged, residing in eight italian towns. three non-toxigenic strains of corynebacterium diphtheriae biotype mitis were isolated from as many healthy children. molecular characterization by ribotyping showed close genetic relation of two of the wild strains with the c7(b) reference strain whereas one of the wild strains showed close genetic relation ... | 2003 | 12910872 |
| isolation of corynebacterium falsenii and description of corynebacterium aquilae sp. nov., from eagles. | biochemical, molecular chemical and molecular genetic studies were performed on seven unidentified gram-positive, rod-shaped organisms recovered from eagles. the strains were provisionally identified as corynebacterium jeikeium with the commercial api coryne system, but they were able to grow under anaerobic conditions and were non-lipophilic. comparative 16s rrna gene sequencing studies demonstrated that the isolates belonged phylogenetically to the genus corynebacterium. three strains were ide ... | 2003 | 12892140 |
| new insights into the biogenesis of the cell envelope of corynebacteria: identification and functional characterization of five new mycoloyltransferase genes in corynebacterium glutamicum. | mycolic acids, the major lipid constituents of corynebacterineae, play an essential role in maintaining the integrity of the bacterial cell envelope. we have previously characterized a corynebacterial mycoloyltransferase (ps1) homologous in its n-terminal part to the three known mycobacterial mycoloyltransferases, the so-called fibronectin-binding proteins a, b and c. the genomes of corynebacterium glutamicum (atcc13032 and cgl2005) and corynebacterium diphtheriae were explored for the occurrenc ... | 2003 | 12855165 |
| regulation of intracellular heme levels by hmx1, a homologue of heme oxygenase, in saccharomyces cerevisiae. | saccharomyces cerevisiae responds to iron deprivation by increasing the transcription of genes involved in the uptake of environmental iron and in the mobilization of vacuolar iron stores. hmx1 is also transcribed under conditions of iron deprivation and is under the control of the major iron-dependent transcription factor, aft1p. although hmx1p exhibits limited homology to heme oxygenases, it has not been shown to be enzymatically active. we find that hmx1p is a resident protein of the endoplas ... | 2003 | 12840010 |
| determinants of the src homology domain 3-like fold. | in eukaryotes, the src homology domain 3 (sh3) is a very important motif in signal transduction. sh3 domains recognize poly-proline-rich peptides and are involved in protein-protein interactions. until now, the existence of sh3 domains has not been demonstrated in prokaryotes. however, the structure of the c-terminal domain of dtxr clearly shows that the fold of this domain is very similar to that of the sh3 domain. in addition, there is evidence that the c-terminal domain of dtxr binds to poly- ... | 2003 | 12837782 |
| infectious diseases. darwinian vaccines. | 2003 | 12775815 | |
| septic arthritis due to a toxigenic strain of corynebacterium diphtheriae gravis. | 2003 | 12740624 | |
| [adaptation mechanisms in the formation of the corynebacterium diphtheriae carrier state]. | the complex clinico-laboratory examination of 92 children aged 3-14 years with the localized form of stomatopharyngeal diphtheria and toxigenic c. diphtheriae (tcd) carrier state was carried out. the children were hospitalized in the clinic of drop infections during the period of 1996-1998. the hydrophobic properties, adhesive, lysozyme, antilysozyme and dnaase activities of 92 tcd strains, as well as the levels of the specific and nonspecific immunity of the macroorganism, were studied. the stu ... | 2000 | 12712509 |
| characterization of the role of the divalent metal ion-dependent transcriptional repressor mntr in the virulence of staphylococcus aureus. | dtxr-type metal ion-dependent repressors, present in many bacterial pathogens, may regulate expression of virulence genes such as that encoding diphtheria toxin. sirr, a dtxr homologue initially identified in staphylococcus epidermidis, governs the expression of the adjacent sitabc operon encoding a putative metal ion abc transporter system. we identified a sirr homologue, mntr, in staphylococcus aureus and demonstrated by gel shift assay that the corynebacterial repressor dtxr binds to the s. a ... | 2003 | 12704132 |
| [vaginal microbiological coenosis and its disorders (etiology, pathogenesis, clinical and laboratory diagnosis (lecture)]. | 2003 | 12688212 | |
| quantitative detection of moraxella catarrhalis in nasopharyngeal secretions by real-time pcr. | the recognition of moraxella catarrhalis as an important cause of respiratory tract infections has been protracted, mainly because it is a frequent commensal organism of the upper respiratory tract and the diagnostic sensitivity of blood or pleural fluid culture is low. given that the amount of m. catarrhalis bacteria in the upper respiratory tract may change during infection, quantification of these bacteria in nasopharyngeal secretions (npss) by real-time pcr may offer a suitable diagnostic ap ... | 2003 | 12682118 |
| origins of metal ion selectivity in the dtxr/mntr family of metalloregulators. | corynebacterium diphtheriae dtxr is an iron-specific repressor of diphtheria toxin expression and iron homeostasis functions. a homologue, mntr, serves as a manganese-specific repressor of mn(ii) uptake in bacillus subtilis. when expressed in b. subtilis, dtxr regulates gene expression in response to either iron or manganese with comparable sensitivity. replacement of two amino acids in the metal-sensing site with the corresponding residues from mntr results in a dtxr mutant that is highly selec ... | 2003 | 12675807 |
| [a case of diphtheria in the netherlands due to an infection with corynebacterium ulcerans]. | a 58-year-old woman was admitted due to a pseudomembranous pharyngitis. the patient had not been vaccinated against diphtheria. corynebacterium ulcerans was cultured from a throat swab. the production of diphtheria toxin by these bacteria was demonstrated with pcr and an immunoprecipitation test. the patient was cared for in respiratory isolation and was treated with benzylpenicillin. she quickly recovered and was discharged four days after admission. a contact investigation did not reveal any d ... | 2003 | 12661461 |
| corynebacterium spheniscorum sp. nov., isolated from the cloacae of wild penguins. | twenty unidentified gram-positive, rod-shaped organisms were recovered from the cloacae of apparently healthy wild penguins (spheniscus magellanicus) and subjected to a polyphasic taxonomic analysis. on the basis of cellular morphology and biochemical criteria, the isolates were tentatively assigned to the genus corynebacterium, although the organisms did not appear to correspond to any recognized species. lipid studies confirmed this generic placement, and comparative 16s rrna gene sequencing s ... | 2003 | 12656150 |
| metal stoichiometry and functional studies of the diphtheria toxin repressor. | diphtheria toxin repressor (dtxr) is a transition metal ion-activated repressor in corynebacterium diphtheriae. dtxr is an iron sensor; metal-bound dtxr represses transcription of genes downstream of the tox operator. wild-type dtxr [dtxr(wt)] and several mutant forms were overexpressed and purified from escherichia coli. dtxr was isolated without bound metal. metal reconstitution gave a binding stoichiometry of 2 per monomer for dtxr(wt) and 1 per monomer for dtxr(h79a) and dtxr(m10a). dna bind ... | 2003 | 12655054 |
| the src homology 3-like domain of the diphtheria toxin repressor (dtxr) modulates repressor activation through interaction with the ancillary metal ion-binding site. | the diphtheria toxin repressor (dtxr) is a transition metal ion-activated repressor that acts as a global regulatory element in the control of iron-sensitive genes in corynebacterium diphtheriae. we recently described (l. sun, j. c. vanderspek, and j. r. murphy, proc. natl. acad. sci. usa 95:14985-14990, 1998) the isolation and in vivo characterization of a hyperactive mutant of dtxr, dtxr(e175k), that appeared to be constitutively active. we demonstrate here that while dtxr(e175k) remains activ ... | 2003 | 12644496 |
| report on the sixth international meeting of the european laboratory working group on diphtheria, brussels, belgium. | in addition to the eastern european resurgence of diphtheria during the last decade, there has also been an emergence of infections caused by non-toxigenic corynebacterium diphtheriae and non-toxigenic, toxin gene bearing c. diphtheriae. given that these strains may manifest as symptomatic infections of differing degrees of severity, their clinical and epidemiological significance need to be assessed. the persistence of toxigenic and non-toxigenic c. diphtheriae in circulation, together with gen ... | 2002 | 12631954 |
| [immune response in adult immunized with adsorbed dt-m anatoxin with reduced antigen content and imovax-dt-adulte vaccine]. | the comparative study of immune response after immunization of adults with adsorbed dt toxoid with reduced antigen content and imovax-dt-adulte vaccine, as well as the safety of these preparations, was made. the study revealed that immunization of adults with adsorbed dt toxoid having reduced antigen content, made in two injections, and the injection of imovax-dt-dulte vaccine, as well as the successive injection of these preparations, produced the same the levels of antitetanus immunity. antidi ... | 2003 | 12630352 |
| infective endocarditis caused by unusual gram-positive pathogens. | of a total of 81 patients hospitalized in the infectious diseases department in 1990-2000 with infectious endocarditis caused by gram-positive pathogen, unusual etiological agents were found in several cases: streptococcus pyogenes, streptococcus pneumoniae, corynebacterium diphtheriae, and gemella morbillorum. cardiac defects were present in the latter two patients: bicuspid aortic valve and tetralogy of fallot. two patients were successfully treated with antibiotics only and one patient with a ... | 2002 | 12630329 |
| genotypic and phenotypic characteristics of corynebacterium diphtheriae strains isolated from patients in belarus during an epidemic period. | one hundred two corynebacterium diphtheriae strains (93 of the gravis biotype and nine of the mitis biotype) isolated from clinical cases during the belarus diphtheria epidemic were characterized by biotyping, toxigenicity testing by the elek test and an indirect hemagglutination assay, phage typing, and ribotyping. the gravis biotype strains were characterized as high and medium toxin producers, and strains of biotype mitis were characterized as low and medium toxin producers. most strains (82 ... | 2003 | 12624069 |
| insights into the genetic organization of the corynebacterium diphtheriae erythromycin resistance plasmid png2 deduced from its complete nucleotide sequence. | the complete nucleotide sequence of the erythromycin resistance plasmid png2 from the human pathogen corynebacterium diphtheriae s601 was determined. the plasmid has a total size of 15,100 bp and contains at least 17 coding regions. comparative genomics identified conserved motifs within replication initiator proteins of corynebacterial plasmids and a novel nucleotide sequence feature, termed 22-bp box, located downstream of the repa gene. the erythromycin resistance determinant erm(x) is flanke ... | 2003 | 12584002 |
| [strain of screening high toxin--producing from corynebacterium diphtheria pw8-weissensee]. | corynebacterium diphtheria pw8-weissensee was grown on different media for screening high toxin produce. through six times of screening (selecting butyrous brilliant smooth small colonies and testing their toxin production capacity) from original strain producing toxin 160 lf/ml, a high toxin--producing descendand culture was obtained, which produced 79% more toxin than the original strain did. | 1998 | 12549392 |
| molecular epidemiology and characteristics of corynebacterium diphtheriae and corynebacterium ulcerans strains isolated in italy during the 1990s. | five cases of diphtheria were reported in italy between january 1990 and june 2001. three cases were confirmed microbiologically by the isolation of toxigenic corynebacterium diphtheriae (two cases) and corynebacterium ulcerans (one case). over the same period, 11 cases of non-toxigenic c. diphtheriae infection were reported to the italian public health institute, from which the causative organism was isolated from a skin infection in one case and from the throat in the other ten. seven of the t ... | 2003 | 12543926 |
| manganese-dependent regulation of the endocarditis-associated virulence factor efaa of enterococcus faecalis. | there is increasing recognition of the emerging role of manganese regulation and acquisition in some pathogenic bacteria. expression of the enterococcus faecalis endocarditis-associated virulence factor efaa is induced by growth in serum. it is demonstrated here that expression of the efacba operon encoding a putative abc-type transporter is regulated by mn(2+). transcription of efacba and efaa production were repressed in mn(2+)-supplemented medium. a mn(2+)-responsive transcriptional regulator ... | 2003 | 12543916 |
| protective levels of diphtheria-neutralizing antibody induced in healthy volunteers by unilateral priming-boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin a. | subunit intranasal vaccines offer the prospect of inducing combined systemic-mucosal immunity against mucosally transmitted infections such as human immunodeficiency virus. however, although human studies have demonstrated the induction of active immunity, secretory immunoglobulin a (siga) responses are variable, and no study has demonstrated protection by accepted vaccine-licensing criteria as measured by direct toxin-neutralizing activity. using the genetically inactivated mutant diphtheria to ... | 2003 | 12540551 |
| [characteristics of antitoxic and antibacterial immune response in nontoxic forms of oropharyngeal diphtheria]. | the enzyme immunoassay system (eia) for differentiation of antibodies in therapeutic heterogeneous antitoxic serum and antibodies to corynebacterium diphtheriae toxigenic strains in patients and carriers was developed. the use of eia permitted the dynamic evaluation of the characteristics of humoral antitoxic and antibacterial immune response in 50 patients with the localized and disseminated forms of stomatopharyngeal diphtheria and 14 "healthy" carriers of toxigenic c. diphtheriae. as revealed ... | 2002 | 12506628 |
| [in vivo activity of amoxicillin in a non-toxigenic corynebacterium diphtheriae rabbit endocarditis experimental model]. | the mortality of non-toxigenic corynebacterium diphtheriae endocarditis is high (27%). one explanation could be tolerance to amoxicillin. the aim of this work was to evaluate in vivo the tolerance phenomenon, in a rabbit endocarditis experimental model. two strains of non-toxigenic corynebacterium diphtheriae were compared: a tolerant one and a non-tolerant one. each animal was randomly assigned to one of the following groups: no treatment, continuous infusion of amoxicillin simulating 200 mg/kg ... | 2002 | 12490412 |
| solution 1h nmr investigation of the active site molecular and electronic structures of substrate-bound, cyanide-inhibited hmuo, a bacterial heme oxygenase from corynebacterium diphtheriae. | the molecular structure and dynamic properties of the active site environment of hmuo, a heme oxygenase (ho) from the pathogenic bacterium corynebacterium diphtheriae, have been investigated by (1)h nmr spectroscopy using the human ho (hho) complex as a homology model. it is demonstrated that not only the spatial contacts among residues and between residues and heme, but the magnetic axes that can be related to the direction and magnitude of the steric tilt of the fecn unit are strongly conserve ... | 2003 | 12480929 |
| [antibody levels to diphtheria in various community segments]. | the aim of this study was to detect the immune status of our population against diphtheria. for this purpose, the levels of diphtheria igg antibodies in various age groups were investigated in 150 subjects aged over 20 years old, by using elisa method. the positive immunity rate against diphtheria was found 62%, while there was no statistically significant difference between the rates of males (66.7%) and females (57.7%) (p > 0.05). eighty percent of subjects aged between 20-29 years, 71.4% of 3 ... | 2002 | 12476762 |
| development of a real-time fluorescence pcr assay for rapid detection of the diphtheria toxin gene. | we developed and evaluated a real-time fluorescence pcr assay for detecting the a and b subunits of diphtheria toxin (tox) gene. when 23 toxigenic corynebacterium diphtheriae strains, 9 nontoxigenic c. diphtheriae strains, and 44 strains representing the diversity of pathogens and normal respiratory flora were tested, this real-time pcr assay exhibited 100% sensitivity and specificity. it allowed for the detection of both subunits of the tox gene at 750 times greater sensitivity (2 cfu) than the ... | 2002 | 12454177 |
| analysis of a dtxr-like metalloregulatory protein, mntr, from corynebacterium diphtheriae that controls expression of an abc metal transporter by an mn(2+)-dependent mechanism. | the dtxr protein is a global iron-dependent repressor in corynebacterium diphtheriae that regulates transcription from multiple promoters. a search of the partially completed c. diphtheriae genome identified a gene, mntr, whose predicted product has significant homology with the dtxr repressor protein. the mntr gene is the terminal gene in a five-gene operon that also carries the mntabcd genes, whose predicted products are homologous to abc metal transporters. transcription of this genetic syste ... | 2002 | 12446639 |
| intracellular viability of toxigenic corynebacterium diphtheriae strains in hep-2 cells. | corynebacterium diphtheriae, generally considered an extracellular coloniser, was evaluated for its ability to enter and survive within hep-2 monolayers by gentamicin protection assay. intracellular viability of hc01 strain, isolated from endocarditis, was more expressive (2.59%) than observed in 241 (0.21%) and cdc-e8392 (1.93%) strains. electron microscopy of c. diphtheriae-infected hep-2 cells revealed intracellular bacteria inside membrane-bound vacuoles. bacterial internalisation was totall ... | 2002 | 12393210 |
| corynebactin and a serine trilactone based analogue: chirality and molecular modeling of ferric complexes. | because the hydrolysis of ferric ion makes it very insoluble in aerobic, near neutral ph environments, most species of bacteria produce siderophores to acquire iron, an essential nutrient. the chirality of the ferric siderophore complex plays an important role in cell recognition, uptake, and utilization. corynebactin, isolated from gram-positive bacteria, is structurally similar to enterobactin, a well-known siderophore first isolated from gram-negative bacteria, but contains l-threonine instea ... | 2002 | 12377042 |
| recognition of dna by fur: a reinterpretation of the fur box consensus sequence. | ferric uptake repressor (fur) proteins regulate the expression of iron homeostasis genes in response to intracellular iron levels. in general, fur proteins bind with high affinity to a 19-bp inverted repeat sequence known as the fur box. an alignment of 19 operator sites recognized by bacillus subtilis fur revealed a different conserved 15-bp (7-1-7) inverted repeat present twice within this 19-bp consensus sequence. we demonstrated using electrophoretic mobility shift assays that this 7-1-7 inv ... | 2002 | 12374814 |
| iron acquisition by gram-positive bacterial pathogens. | for the majority of bacterial pathogens, acquisition of iron from host proteins is a prerequisite for growth during infection. the mechanisms by which gram-negative bacteria obtain iron from host proteins have been well described, but only recently has substantial progress been made in identifying these mechanisms for gram-positive bacterial pathogens. this review provides an overview of the existing knowledge on the genetic basis of iron transport for important gram-positive pathogens. | 2002 | 12361915 |
| construction and characterization of transposon insertion mutations in corynebacterium diphtheriae that affect expression of the diphtheria toxin repressor (dtxr). | transcription of the bacteriophage-borne diphtheria toxin gene tox is negatively regulated, in response to intracellular fe(2+) concentration, by the chromosomally encoded diphtheria toxin repressor (dtxr). due to a scarcity of tools, genetic analysis of corynebacterium diphtheriae has primarily relied on analysis of chemically induced and spontaneously occurring mutants and on the results of experiments with c. diphtheriae genes cloned in escherichia coli or analyzed in vitro. we modified a tn5 ... | 2002 | 12270831 |
| efficient electrotransformation of corynebacterium diphtheriae with a mini-replicon derived from the corynebacterium glutamicum plasmid pga1. | efficient transformation of the human pathogen corynebacterium diphtheriae was achieved with novel cloning vectors consisting of a mini-replicon from the cryptic c. glutamicum plasmid pga1 as well as of the aph(3')-iia or teta(z ) antibiotic resistance genes. plasmid-containing transformants of c. diphtheriae were recovered at frequencies ranging from 1.3 x 10(5) to 4.8 x 10(6) colony forming units (cfu)/microg of plasmid dna. vector dna was directly transferred from escherichia coli into c. dip ... | 2002 | 12232668 |
| [specificity of antibodies to diphtheria toxin subunits in children with various forms of diphtheria infections]. | in order to study the specificity of serum antibodies to separate subunits of diphtheria toxin, sds-electrophoresis of diphtheria toxin preliminary disintegrated on the subunits via trypsin treatment was performed, followed by immunoblotting assay. 86 blood serum samples of children with diphtheria carriers of toxigenic and non-toxigenic strains of corynebacterium diphtheriae as well as children with other infectious diseases similar to diphtheria in their clinical manifestation, and healthy one ... | 2001 | 12199083 |
| [diphtheria--results of an immunologic survey]. | the objective of the immunological survey (is) was in addition to assessment of the overall immunity of the slovak population against diphtheria to test the effectiveness of vaccination and suitability of the used vaccination pattern and to assess the persistence of antibodies against diphtheria in more advanced age, and possibly the need of revaccination. the sera were tested by means of the neutralization test on cell cultures. the level of diphtheria antitoxin was assessed quantitatively. in ... | 2002 | 12184194 |
| [cutaneous leishmaniotic ulcers with corynebacterium diphtheriae]. | in a prospective study to evaluate the influence of secondary bacterial infection on the evaluation of cutaneous leishmaniasis, in corte de pedra (bahia), we isolated corynebacterium diphtheriae in 7 (8.3%) out of 84 patients with ulcers studied. due to the small number of patients with the presence of the bacteria in the ulcer, we could not conclude whether corynebacterium diphtheriae behaves only as a colonizer nor its influence on the healing of the leishmaniotic ulcer. | 2002 | 12170325 |