Publications

bartonella bovis in cattle in africa.		2004	15627528
bartonella henselae inhibits apoptosis in mono mac 6 cells.	bartonella henselae causes the vasculoproliferative disorders bacillary angiomatosis and peliosis probably resulting from the release of vasculoendothelial growth factor (vegf) from infected epithelial or monocytic host cells. here we demonstrate that b. henselae in addition to vegf induction was also capable of inhibiting the endogenous sucide programme of monocytic host cells. our results show that b. henselae inhibits pyrrolidine dithiocarbamate (pdtc)-induced apoptosis in mono mac 6 cells. b ...	2005	15617526
evidence of bartonella sp. in questing adult and nymphal ixodes ricinus ticks from france and co-infection with borrelia burgdorferi sensu lato and babesia sp.	ticks are known vectors for a wide range of pathogenic microorganisms. their role in the transmission of some others is so far only suspected. ticks can transmit multiple pathogens, however, little is known about the co-existence of these pathogens within questing ticks. we looked for the presence of dna from three micro-organisms, bartonella sp., borrelia burgdorferi sensu lato and babesia sp. which are known or suspected tick-borne pathogens, using a cohort of 92 questing ixodes ricinus ticks ...	2005	15610725
guidelines for the diagnosis of tick-borne bacterial diseases in europe.	ticks are obligate haematophagous acarines that parasitise every class of vertebrate (including man) and have a worldwide distribution. an increasing awareness of tick-borne diseases among clinicians and scientific researchers has led to the recent description of a number of emerging tick-borne bacterial diseases. since the identification of borrelia burgdorferi as the agent of lyme disease in 1982, 11 tick-borne human bacterial pathogens have been described in europe. aetiological diagnosis of ...	2004	15606643
demonstration of intracellular microorganisms (rickettsia spp., chlamydia pneumoniae, bartonella spp.) in pathological human aortic valves by pcr.	rickettsiae, which causes vasculitis, has not been linked to atherosclerotic cardiovascular disease in contrast to chlamydia pneumoniae whose association with coronary artery disease and with sclerotic heart valves in patients undergoing aortic valve replacement is well established, even if causality is yet to unproven. in the search for any of these infectious agents, 84 pathological and 15 normal aortic heart valves of patients undergoing forensic autopsy were analysed by pcr and dna-sequencin ...	2005	15603840
late onset of serologic positive titers in a patient with parinaud's oculoglandular syndrome.	to report a case of parinaud's oculoglandular syndrome (pos) in which, despite the initially negative, a late onset of serologic positive titers was observed.	2004	15590554
ddei rflp for 16s rdna typing in bartonella henselae.		2004	15585508
the bartonella henselae sucb gene encodes a dihydrolipoamide succinyltransferase protein reactive with sera from patients with cat-scratch disease.	bartonella henselae is a recently recognized pathogenic bacterium associated with cat-scratch disease, bacillary angiomatosis and bacillary peliosis. a recombinant clone expressing an immunoreactive antigen of b. henselae was isolated by screening a genomic dna cosmid library by western blotting with sera pooled from patients positive for b. henselae igg antibodies by indirect immunofluorescence (ifa). the deduced amino acid sequence of the 43.7 kda encoded protein was found to be 76.3 % identic ...	2004	15585501
nationalism, carrión's disease and medical geography in the peruvian andes.	during the turn of the 20th century medical geography in peru concentrated in the study of a native disease (bartonellosis, also known as carrión's disease and verruga peruana) and reinforced the relationship between the country's 'natural' regions (coast, highlands and amazon) and different patterns of disease. expert knowledge on these themes was portrayed as important not only for the practice of medicine but also for the development of the country. this knowledge was instrumental for an emer ...	2003	15584200
seroprevalence of bartonella henselae and bartonella quintana infections in children from central and northern jordan.	to investigate the prevalence of antibodies to bartonella henselae (b.henselae) and bartonella quintana (b.quintana) among children from central and northern jordan.	2004	15573198
bacterial models for tumor development. mini-review.	the tumor-inducing effects of agrobacterium, bartonella and helicobacter bacterial species are compared step by step. an analogy for the existence of these individual steps is considered in connection with the development of cancer. the transformations of eukaryotic cells occur in particular in the type iv secretion system, i.e. involving the simultaneous transmission of dna and protein from bacterial cells to eukaryotic cells. thus, transfected cells facilitate the indefinite growth of tissue c ...	2004	15571072
a mechanic with a bad valve: blood-culture-negative endocarditis.	a 33-year-old man with a known bicuspid aortic valve presented with fever, chills, progressive fatigue, anorexia, and night sweats. echocardiography confirmed aortic-valve endocarditis, but blood cultures remained negative. bartonella henselae endocarditis was ultimately confirmed by serology as well as by immunohistochemistry and pcr testing of the excised valve. the patient recovered with appropriate antibiotic therapy. b henselae is a common cause of culture-negative endocarditis. it predomin ...	2004	15567127
[bartonelloses].	bartonellae belong to less known causal agents of many human diseases. they are gram-negative bacteria growing slowly on culture media enriched with hemin or bovine serum. the genus bartonella, which currently involves more than 15 species, is present worldwide. bartonellae live in natural foci in dependence on the occurrence of natural host (rodents, felines, canidae, human) and insect vector (flea, tick, louse). by reservoir animals they usually cause permanent intraerythrocytic bacteraemia wi ...	2004	15558448
molecular detection of bartonella quintana dna in the dental pulp of a homeless patient.	dental pulp has been proposed as a suitable tissue sample for the identification of pathogenic organisms. using pcr with two specific gene targets, bartonella quintana dna was detected in the dental pulp extracted from the tooth of a homeless patient. the patient had been bacteremic 6 months previously but was not when the tooth was sampled.	2004	15558347
in vitro model of bartonella henselae-induced angiogenesis.	bartonella henselae is a gram-negative pathogen that causes angiogenesis. here, i establish in vitro models to study bartonella-induced blood vessel formation. i found that b. henselae induces long-term endothelial survival and tubular differentiation within type i collagen matrix.	2004	15557658
seroprevalences of antibodies against bartonella henselae and toxoplasma gondii and fecal shedding of cryptosporidium spp, giardia spp, and toxocara cati in feral and pet domestic cats.	to compare seroprevalences of antibodies against bartonella henselae and toxoplasma gondii and fecal shedding of cryptosporidium spp, giardia spp, and toxocara cati in feral and pet domestic cats.	2004	15552314
guidelines for the antibiotic treatment of endocarditis in adults: report of the working party of the british society for antimicrobial chemotherapy.	the bsac guidelines on endocarditis were last published in 1998. the guidelines presented here have been updated and extended to reflect changes in both the antibiotic resistance characteristics of causative organisms and the availability of new antibiotics. randomized, controlled trials suitable for the development of evidenced-based guidelines in this area are still lacking, and therefore a consensus approach has again been adopted. the guidelines cover diagnosis and laboratory testing, suitab ...	2004	15546974
diversity of bartonellae associated with small mammals inhabiting free state province, south africa.	the prevalence and diversity of bartonellae infecting the blood of 10 small mammal species inhabiting nine nature reserves of the free state province, south africa, was assessed using phenotypic, genotypic and phylogenetic methods. of 86 small mammals sampled, 38 animals belonging to five different species yielded putative bartonellae. thirty-two isolates were confirmed as bartonellae and were characterized by comparison of partial citrate synthase gene (glta) sequences. phylogenetic reconstruct ...	2004	15545418
bartonella quintana-induced apoptosis inhibition of human endothelial cells is associated with p38 and sapk/jnk modulation and with stimulation of mitosis.	previous studies demonstrated that live bartonella quintana often induces angioproliferative lesions in humans. it modulates endothelial cell apoptotic and inflammatory patterns, thus inducing a very early overexpression of caspase 8 and apaf-1 and increasing mrna production of tnf-alpha, interleukin-8, and e-selectin. however, starting at 10 hours postinfection, the bacteria provoke antiapoptotic effects that induce an increase of bcl-2 gene transcription. to gain further insight into the cellu ...	2004	15541600
bartonella adhesin a mediates a proangiogenic host cell response.	bartonella henselae causes vasculoproliferative disorders in humans. we identified a nonfimbrial adhesin of b. henselae designated as bartonella adhesin a (bada). bada is a 340-kd outer membrane protein encoded by the 9.3-kb bada gene. it has a modular structure and contains domains homologous to the yersinia enterocolitica nonfimbrial adhesin (yersinia adhesin a). expression of bada was restored in a bada-deficient transposon mutant by complementation in trans. bada mediates the binding of b. h ...	2004	15534369
isolation of bartonella schoenbuchensis from lipoptena cervi, a blood-sucking arthropod causing deer ked dermatitis.	bartonella schoenbuchensis, which commonly causes bacteremia in ruminants, was isolated from the deer ked lipoptena cervi and was shown to localize to the midgut of this blood-sucking arthropod, causing deer ked dermatitis in humans. the role of b. schoenbuchensis in the etiology of deer ked dermatitis should be further investigated.	2004	15528732
latent infective endocarditis: epidemiology and clinical characteristics of patients with unsuspected endocarditis detected after elective valve replacement.	the diagnosis of infective endocarditis is usually made on the basis of clinical and laboratory criteria and may be confirmed by histologic examination or culture of excised valves. we tried to determine the incidence and significance of inflammatory changes in valves excised during operations for reasons other than infective endocarditis.	2004	15511445
identification of bartonella species in rodents, shrews and cats in denmark: detection of two b. henselae variants, one in cats and the other in the long-tailed field mouse.	small mammals and stray cats were trapped in two areas of north zealand, denmark, and their blood cultured for hemotrophic bacteria. bacterial isolates were recovered in pure culture and subjected to 16s rdna gene sequencing. bartonella species were isolated from five mammalian species: b. grahamii from microtus agrestis (field vole) and apodemus flavicollis (yellow-necked field mouse); b. taylorii from m. agrestis, a. flavicollis and a. sylvaticus (long-tailed field mouse); b. tribocorum from a ...	2004	15511270
[cat scrach disease].		2004	15498227
acinetobacter baumannii in human body louse.	while we were isolating bartonella quintana from body lice, 40 acinetobacter baumannii strains were also isolated and genotyped. one clone was unique and the other was ampicillin susceptible. a. baumannii dna was later detected in 21% of 622 lice collected worldwide. these findings show an a. baumannii epidemic in human body lice.	2004	15498175
[screening for antibodies against zoonotic agents among employees of the zoological garden of vienna, schönbrunn, austria].	the aim of this study was to investigate the prevalence of antibodies against zoonotic agents in employees of the zoological garden of vienna, schönbrunn, austria. sixty out of 120 employees participated in the study. in 97% of them antibodies to at least one zoonotic agent were identified. only two participants were free of antibodies to the zoonotic agents tested. the following seroprevalences (in brackets) were obtained: viral zoonotic (and potentially zoonotic) agents: influenzavirus a/h1n1 ...	2004	15495931
doxycycline, gastrointestinal bleeding, and thrombotic microangiopathy.		2004	15495239
molecular detection of bartonella henselae dna in the dental pulp of 800-year-old french cats.	bartonella species are responsible for chronic bacteremia in domestic cats, which raises a question about the antiquity of the relationship between bartonella species and cats that act as reservoirs for the organism. the sequencing of bartonella pap31 and groel genes from the dental pulp of cats dating from the 13th to 16th centuries identified the presence of b. henselae genotype houston; the observation of a unique mutation in the results of pcr assays for bartonella species ruled out modern d ...	2004	15494918
molecular and cellular basis of bartonella pathogenesis.	the genus bartonella comprises several important human pathogens that cause a wide range of clinical manifestations: cat-scratch disease, trench fever, carrion's disease, bacteremia with fever, bacillary angiomatosis and peliosis, endocarditis, and neuroretinitis. common features of bartonellae include transmission by blood-sucking arthropods and the specific interaction with endothelial cells and erythrocytes of their mammalian hosts. for each bartonella species, the invasion and persistent int ...	2004	15487942
acute hemiplegia associated with cat-scratch disease.	cat scratch disease (csd) is an infectious illness caused by a gram-negative rod named bartonella henselae. typical csd is characterized by a small skin lesion at the site of a scratch or a bite, followed by regional lymphadenopathy, one to two weeks later. atypical forms may present as ocular manifestations, neurological manifestations, hepatosplenic involvement and vertebral osteomyelitis. among neurological complications, encephalopathy is by far the most common. other neurological manifestat ...	2004	15476060
[sudden sight impairment revealing a cat-scratch disease: report of three cases].	cat-scratch disease is a frequent but innocuous cause of chronic lymphadenopathy in children. numerous atypical forms have been described. we report three cases of acute sight impairment revealing a cat-scratch disease. background: a 13 year-old boy and two girls aged 10 and 13 suffered from a sudden bilateral sight impairment with papillary edema, with fever in two cases. neurological examinations, x-rays and lumbar puncture results were found normal. however, all patients were tested positive ...	2004	15475278
detection of bartonella quintana by direct immunofluorescence examination of blood smears of a patient with acute trench fever.	we report a case of bartonella quintana acute symptomatic infection in a homeless man, presenting as a typical trench fever. b. quintana has been retrieved in erythrocytes in large clusters and in erythroblasts. direct immunofluorescence of blood smears allows a rapid diagnosis.	2004	15472378
role of hippoboscidae flies as potential vectors of bartonella spp. infecting wild and domestic ruminants.	the putative role of biting flies in bartonella transmission among ruminants was investigated. amplification of the bartonella citrate synthase gene from 83 hippoboscidae was detected in 94% of 48 adult lipoptena cervi flies, 71% of 17 adult hippobosca equina flies, 100% of 20 adult melophagus ovinus flies, and 100% of 10 m. ovinus pupae. our findings suggest that hippoboscidae play a role in the transmission of bartonella among ruminants. the vertical transmission of bartonella in m. ovinus and ...	2004	15466580
[subcutaneous nodules with malignant presentation, but caused by infection].	three patients, a woman aged 32, a boy aged 6.5 and a man aged 56 years, presented with a subcutaneous mass suggesting a malignancy: respectively a rubbery swelling, painful to the touch below the left scapula, a partly massive, partly soft swelling on the inside of the left upper leg, and a non-fluctuating mass near the right eighth rib, parasternally. additional diagnostic investigation revealed an infectious cause: respectively mycobacterium tuberculosis, bartonella henselae and salmonella ty ...	2004	15455512
[hepatitis during the course of bartonellosis (carrion's disease) study of 2 cases with hepatobiliary function tests with special reference to the colloidal gold and cephalin-cholesterol reactions].		1950	15440605
a non-pathogenic bartonella-like organism developing in embryonate eggs after injection with haemobartonella muris.		1950	15428634
experimental anemias in the rat; i. macrocytic anemia in chronic pteroylglutamic acid deficiency and after splenectomy in bartonella muris infection.		1950	15414205
clinical manifestations of carrión's disease.		1949	15393033
a study of 22 cases of carrion's disease with intercurrent malaria.		1949	15392068
proteomic analysis of the sarcosine-insoluble outer membrane fraction of the bacterial pathogen bartonella henselae.	bartonella henselae is an emerging zoonotic pathogen causing a wide range of disease manifestations in humans. in this study, we report on the analysis of the sarcosine-insoluble outer membrane fraction of b. henselae atcc 49882 houston-1 by one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis (1-d sds-page) and two-dimensional nonequilibrium ph gradient polyacrylamide gel electrophoresis (2-d nephge). protein species were identified by matrix-assisted laser desorption/ioniz ...	2004	15378747
organismal effects of pesticide exposure on meadow voles (microtus pennsylvanicus) living in golf course ecosystems: developmental instability, clinical hematology, body condition, and blood parasitology.	this is the second of two articles reporting the results of a nonlethal biomonitoring study that quantified the effects of pesticide exposure on meadow voles (microtus pennsylvanicus) living in golf course ecosystems of the ottawa/gatineau region (on and pq, canada, respectively). in the present article, we describe results of measurements regarding developmental instability (e.g., fluctuating asymmetry), congenital birth defects (e.g., skeletal terata), clinical hematology (e.g., differential c ...	2004	15376537
low seroprevalence of bartonella species in danish elite orienteers.	in the 1990s, studies were conducted to investigate 16 episodes of sudden unexpected cardiac death (sucd) among swedish elite orienteers during the period from 1979 to 1992. a case control study revealed that a significantly higher proportion of swedish elite orienteers were b. elizabethae seropositive compared to controls. the aim of our study, designed as a case-control study, was to determine whether similarly high rates of b. elizabethae seropositivity were present among danish elite oriente ...	2004	15370673
bartonella henselae igg antibodies are prevalent in dogs from southeastern usa.	in contrast to the large body of literature regarding bartonella henselae in humans and cats, there is little information about b. henselae as an infectious agent in dogs. due to the paucity of information regarding the b. henselae serology in dogs, we performed a cross-sectional serosurvey using b. henselae antigen in order to compare the seroprevalence between sick and healthy dogs from the south-eastern usa. ninety-nine sera were collected from clinically healthy dogs. three hundred and one s ...	2004	15369661
[solitary nontuberculous mycobacterial infection of a cervical lymph node caused by bartonella henselae (cat scratch disease)].	cat scratch disease (csd) is a common cause of subacute regional lymphadenopathy. cats are the principal reservoir of bartonella henselae, the etiologic agent in most cases of csd. because the histopathological findings are typical but not specific, a wide range of other agents must be considered in differential diagnosis. we report on a patient with a solitary swelling of the neck which remained over months with initial features suggestive of unspecific lymphadenitis, but who, after careful his ...	2004	15365888
liver and spleen abscesses without endocarditis due to bartonella quintana in an immunocompetent host.		2004	15365873
clinical implication of prolonged fever in children with cat scratch disease.	cat scratch disease, caused by bartonella henselae, typically presents with a localized lymphadenopathy with a brief period of fever and general symptoms. however, there are atypical cases with a wide spectrum of clinical manifestations including prolonged fever (> or =37.5 degrees c, for more than 7 days), or with systemic complication, or without lymphadenopathy. we analyzed relationships among those manifestations in children with cat scratch disease. a total of 127 patients were serologicall ...	2004	15365864
prevalence of infectious diseases in feral cats in northern florida.	objectives of this study were to determine prevalence of infection in feral cats in northern florida with a select group of infectious organisms and to determine risk factors for infection. blood samples or sera from 553 cats were tested with a panel of antibody, antigen or pcr assays. male cats were at higher risk for fiv, mycoplasma haemofelis, and m. haemominutum. infection with either felv or fiv was associated with increased risk for coinfection with the other retrovirus, m. haemofelis, or ...	2004	15363760
[evaluation of isolation media for the detection of bartonella henselae--isolation of bartonella henselae from domestic cats].	bartonella henselae is a causative agent of cat scratch disease. we preliminarily tested four media for the bacterial growth, including agar plates with sheep, horse or rabbit blood, and chocolate agar. of these media, rabbit blood and chocolate agar plate were found to be more excellent for the growth than the medium with sheep or horse blood. blood samples from 60 domestic cats in yamaguchi prefecture were then cultured using 7% rabbit blood agar plates and bactec9050 (bd), automated blood cul ...	2004	15359889
[hepatic abscesses in childhood: retrospective study about 33 cases observed in new-caledonia between 1985 and 2003].	hepatic abscesses in childhood are rarely observed in europe. the aim of this word was to study how to diagnose and how to treat an hepatic abscess.	2004	15350993
a family of variably expressed outer-membrane proteins (vomp) mediates adhesion and autoaggregation in bartonella quintana.	bartonella species are fastidious, gram-negative human pathogens that can persist in the host bloodstream for years and bind to and invade several types of host cells. for many pathogens, adhesion to host cells and extracellular matrix (ecm) components is a critical virulence determinant. bacteria often vary expression of surface adhesins by phase or antigenic variation to subvert the host immune response and permit adaptive interaction with different host structures. we developed a macaque anim ...	2004	15347808
genome update: promoter profiles.		2004	15347738
the right answer.		2004	15337400
infective endocarditis: a review of the best treatment options.	despite significant advances in antimicrobial therapy and an enhanced ability to diagnose and treat complications, infective endocarditis is still associated with substantial morbidity and mortality today, and its incidence has not decreased over the past decades. this apparent paradox may be explained by a progressive change in risk factors, leading to an evolution in its epidemiological and clinical features. in fact, new risk factors for endocarditis have emerged, such as intravenous drug abu ...	2004	15330728
pathogen carriage by the cat flea ctenocephalides felis (bouché) in the united kingdom.	the carriage of bartonella, rickettsia felis and haemoplasma species was investigated in cat fleas (ctenocephalides felis) collected from 121 cats and dogs in the united kingdom. dna extracted from fleas was analysed using genus and species-specific pcr and amplicons were characterised using dna sequencing. fifty percent of flea samples were pcr positive for at least one pathogen. twenty one percent were positive for r. felis, 17% for bartonella henselae, 40% for haemoplasma species and 20% were ...	2004	15327793
bartonella spp. dna associated with biting flies from california.	bartonella dna was investigated in 104 horn flies (haematobia spp.), 60 stable flies (stomoxys spp.), 11 deer flies (chrysops spp.), and 11 horse flies (tabanus spp.) collected on cattle in california. partial sequencing indicated b. bovis dna in the horn fly pool and b. henselae type m dna in one stable fly.	2004	15324557
[study on bartonella infection using molecular biological diagnostic techniques from china].	to establish polymerase chain reaction (pcr) technique for the detection of specific genes related to species of genus bartonella, and for diagnosing clinically suspected cat-scratch disease (csd) case complicated with pneumonia on both lungs. the appearance of bartonella infectious diseases calls for genus and species detection and tools for identification in order to make clinical diagnosis and carry on epidemiological studies.	2004	15308042
cat-scratch disease presenting as a breast mass.	the case of a 14-y-old girl who presented with a mass in her left breast after having contact with a guinea pig is presented. the diagnosis of cat-scratch disease was made by detection of bartonella henselae dna by pcr analysis of abscess aspirate.	2004	15307578
disseminated infection with bartonella henselae as a cause of spontaneous splenic rupture.	a 65-year-old man developed massive hemoperitoneum secondary to spontaneous splenic rupture. histopathological analysis of the spleen demonstrated necrotizing granulomas. results of serological tests indicated infection with a species of bartonella, and immunohistochemical staining established bartonella henselae as the cause of splenitis. to our knowledge, this represents the first reported case of spontaneous splenic rupture caused by infection with a species of bartonella.	2004	15307019
[prevalence of bartonella henselae in stray and domestic cats in different italian areas: evaluation of the potential risk of transmission of bartonella to humans].	bartonella henselae is the major etiological agent of cat scratch disease in humans. cats act as the natural reservoir of b. henselae and can transmit the infection to humans by bite or scratch. the diffusion of b. henselae was evaluated by seroprevalence and bacteremic status in different stray cat populations located in nine areas of northern italy. a total of 1585 cats were tested by blood culture and 361 (23%) resulted bacteremic; 1416 out off 1585 cats were also tested for bartonella hensel ...	2004	15305701
genomes beyond compare.		2004	15303267
cat-scratch disease: historic, clinical, and pathologic perspectives.	cat-scratch disease (csd) initially was described in 1931, but the etiologic agent (bartonella henselae) was not elucidated until decades later. this disease is the most common cause of chronic lymphadenopathy among children and adolescents, characteristically manifesting as subacute regional lymphadenitis with an associated inoculation site due to a cat scratch or bite, often accompanied by fever. the hallmark histologic lesion is granulomatous inflammation with a central stellate microabscess. ...	2004	15298152
isolation of bartonella rattimassiliensis sp. nov. and bartonella phoceensis sp. nov. from european rattus norvegicus.	thirty-three isolates of bartonella spp., including 11 isolates not belonging to previously known species, were isolated from 66 rattus norvegicus subjects trapped in the city of marseille, france. based on seven different gene sequences, the 11 isolates were assigned to bartonella rattimassiliensis sp. nov. and bartonella phoceensis sp. nov.	2004	15297537
population genetic analysis of bartonella bacilliformis isolates from areas of peru where carrion's disease is endemic and epidemic.	carrion's disease is caused by infection with the alpha-proteobacterium bartonella bacilliformis. distribution of the disease is considered coincident with the distribution of its known vector, the sand fly lutzomyia verrucarum. recent epidemics of b. bacilliformis infections associated with atypical symptomatology in nonendemic regions have raised questions regarding the historic and present distribution of this bacterium and the scope of disease that infection causes. phylogenetic relationship ...	2004	15297516
bartonella koehlerae, a new cat-associated agent of culture-negative human endocarditis.	bartonella koehlerae is reported for the first time to be a human pathogen that causes culture-negative endocarditis. it is also shown that this species, isolated twice before from domestic cats, can be recovered as well from a stray cat population in israel. this work follows a recent report of the same case in which the causative agent was misidentified as b. henselae, based on serology and pcr-restriction fragment length polymorphism (rflp) analysis (a. schattner, o. zimhony, b. avidor, and m ...	2004	15297484
rapid detection and differentiation of bartonella spp. by a single-run real-time pcr.	a real-time pcr for the identification and differentiation of bartonella spp. based on the detection of mutations in an internal region of the glta gene by thermal analysis was developed. the assay included a simultaneous detection of the amplicons by direct hybridization of lcred and fluorescein-labelled probes coupled with melting curve analysis by the use of fluorescence resonance energy transfer technology. the protocol allowed establishing genospecie identity in less than 1 h without a need ...	2004	15294318
carrion's disease (bartonellosis bacilliformis) confirmed by histopathology in the high forest of peru.	bartonellosis or carrion's disease is endemic in some regions of peru, classically found in the inter-andean valleys located between 500 and 3200 meters above sea level. we report the case of a 43 year-old male patient, farmer, who was born in the pichanaki district (chanchamayo, junin), located in the high forest of peru. he presented with disseminated, raised, erythematous cutaneous lesions, some of which bled. the distribution of these lesions included the nasal mucosa and penile region. addi ...	2004	15286824
ectoparasites of gray squirrels in two different habitats and screening of selected ectoparasites for bartonellae.	gray squirrels, sciurus carolinensis, were livetrapped in 2 different habitat types, woodland (67 squirrels) and parkland (53 squirrels), in southeastern georgia. ectoparasites were recovered from anesthetized squirrels and compared between hosts from the 2 habitats. because of the absence of low vegetation in parkland habitats, it was hypothesized that the ectoparasite fauna, especially ticks and chiggers, would be more diverse on woodland squirrels. the results were generally in agreement with ...	2004	15270090
evaluation of indirect fluorescence antibody assay for detection of bartonella clarridgeiae and seroprevalence of b. clarridgeiae among patients with suspected cat scratch disease.	the possibility of bartonella clarridgeiae being a causative agent of cat scratch disease (csd) was investigated by using indirect fluorescence antibody assays with 288 suspected csd patients. immunoglobulin g antibody to noncocultivated b. clarridgeiae was suitable only for detection of b. clarridgeiae antibody. significant cross-reactivity between bartonella henselae and b. clarridgeiae was noted, and no csd case caused by b. clarridgeiae was detected.	2004	15243113
multiplex real-time pcr for detection of anaplasma phagocytophilum and borrelia burgdorferi.	a multiplex real-time pcr assay was developed for the simultaneous detection of anaplasma phagocytophilum and borrelia burgdorferi. the assay was tested on various anaplasma, borrelia, erhlichia, and rickettsia species, as well as on bartonella henselae and escherichia coli, and the assay was found to be highly specific for a. phagocytophilum and the borrelia species tested (b. burgdorferi, b. parkeri, b. andersonii, and b. bissettii). the analytical sensitivity of the assay is comparable to tha ...	2004	15243077
frontal and stealth attack strategies in microbial pathogenesis.	interactions between microbes and human hosts can range from a benign, even symbiotic collaboration to a competition that may turn fatal--resulting in death of the host, the microbe or both. despite advances that have been made over the past decades in understanding microbial pathogens, more people worldwide still die every year from infectious disease than from any other cause. this highlights the relevance of continuing to probe the mechanisms used by microorganisms to cause disease, and empha ...	2004	15241423
report of an unusual case of persistent bacteremia by bartonella bacilliformis in a splenectomized patient.	we report a case of a 56-year-old man with a history of splenectomy for idiopathic thrombocytopenic purpura who developed persistent bacteremia in the acute phase of human bartonellosis. this patient did not develop hemolytic anemia. only after several courses of antibiotic treatment was the infection eradicated. this is an unusual case of overwhelming post-splenectomy infection by bartonella bacilliformis, which provides clinical evidence that the spleen is a critical effector organ of clearanc ...	2004	15238689
interaction between protein subunits of the type iv secretion system of bartonella henselae.	in this study we used the yeast two-hybrid system to identify interactions between protein subunits of the virb type iv secretion system of bartonella henselae. we report interactions between inner membrane and periplasmic proteins, the pilus polypeptide, and the core complex and a novel interaction between virb3 and virb5.	2004	15231811
seroprevalence of and risk factors for bartonella henselae and bartonella quintana infections among pet cats in jordan.	to determine the seroprevalences of bartonella henselae and bartonella quintana antibodies in jordanian pet cats, serum samples from 153 cats from three geographical regions were analyzed. seroprevalences were determined by indirect immunofluorescence. the true seroprevalences to b. henselae and b. quintana were 32 and 1.5%, respectively. the seroprevalence of b. henselae-specific antibodies in cats from northern jordan was significantly higher than in cats from the central or southern parts of ...	2004	15219970
rickettsia felis, bartonella henselae, and b. clarridgeiae, new zealand.		2004	15216855
bartonella species isolated from rodents, greece.		2004	15216849
the louse-borne human pathogen bartonella quintana is a genomic derivative of the zoonotic agent bartonella henselae.	we present the complete genomes of two human pathogens, bartonella quintana (1,581,384 bp) and bartonella henselae (1,931,047 bp). the two pathogens maintain several similarities in being transmitted by insect vectors, using mammalian reservoirs, infecting similar cell types (endothelial cells and erythrocytes) and causing vasculoproliferative changes in immunocompromised hosts. a primary difference between the two pathogens is their reservoir ecology. whereas b. quintana is a specialist, using ...	2004	15210978
emerging issues in infective endocarditis.	infective endocarditis, a serious infection of the endocardium of the heart, particularly the heart valves, is associated with a high degree of illness and death. it generally occurs in patients with altered and abnormal heart architecture, in combination with exposure to bacteria through trauma and other potentially high-risk activities involving transient bacteremia. knowledge about the origins of endocarditis stems from the work of fernel in the early 1500s, and yet this infection still prese ...	2004	15207065
flea-borne bartonella grahamii and bartonella taylorii in bank voles.	bartonella species are increasingly associated with a range of human and animal diseases. despite this, we have a poor understanding of the ecology and epidemiology of many species, especially those circulating in wild populations. previous studies have demonstrated that a diverse range of bartonella species are abundant in wild rodent populations; little is known regarding their modes of transmission, although both direct and indirect routes have been suggested. in this study, with bank voles ( ...	2004	15200860
bartonella henselae causing severe and protracted illness in an otherwise healthy person.	bartonella henselae is an emerging pathogen capable of causing severe disease. we report a case of severe protracted illness in an otherwise healthy police dog handler. the patient recovered slowly after antibiotic treatment. this case report emphasizes the importance of considering b. henselae infections in patients with fever of unknown origin.	2004	15198195
lack of bartonella sp. in 167 ixodes ricinus ticks collected in central sweden.	sudden death in swedish orienteers was demonstrated to be significantly associated with antibodies to bartonella sp. to test if these antibodies could be related with tick exposure, we searched bartonella sp. in ixodes ricinus ticks using specific pcr amplification and culture. no bartonella sp. was detected in 167 ticks tested.	2004	15198190
prevalence of borrelia burgdorferi, bartonella spp., babesia microti, and anaplasma phagocytophila in ixodes scapularis ticks collected in northern new jersey.	pcr analysis of ixodes scapularis ticks collected in new jersey identified infections with borrelia burgdorferi (33.6%), babesia microti (8.4%), anaplasma phagocytophila (1.9%), and bartonella spp. (34.5%). the i. scapularis tick is a potential pathogen vector that can cause coinfection and contribute to the variety of clinical responses noted in some tick-borne disease patients.	2004	15184475
infection and blood transfusion: a guide to donor screening.	in recent years, blood-component therapy has become more accessible in veterinary practice. as with human medicine, care must be taken to minimize the risk of disease transmission from donor to recipient. determining the appropriate diseases to screen for is complicated by regional variations in disease incidence, the existence of chronic carrier states for some diseases, the difficulty in screening-test selection, and testing cost. the feline diseases considered include retroviral infections, f ...	2004	15179926
cat scratch disease in two brothers.		2004	15179075
[bacteria of bartonella genus: characteristics, pathogenicity factors and methods of molecular-genetic investigation].	bartonella bacteria are an agent of a variety of human and animal diseases whose etiology used to be unknown. the survey contains a description of the above bacteria with the established pathogenicity factors and with the molecular and genetic approaches to studies of genes' functions and of their regulation being in the focus of attention. modern methods related with the genus-specific and species-specific determination and identification of bartonella bacteria are discussed.	2004	15164714
legionella dumoffii djla, a member of the dnaj family, is required for intracellular growth.	legionella dumoffii is one of the common causes of legionnaires' disease and is capable of replicating in macrophages. to understand the mechanism of survival within macrophages, transposon mutagenesis was employed to isolate the genes necessary for intracellular growth. we identified four defective mutants after screening 790 transposon insertion mutants. two transposon insertions were in genes homologous to icmb or dotc, within dot/icm loci, required for intracellular multiplication of l. pneu ...	2004	15155669
predominant outer membrane antigens of bartonella henselae.	a hallmark of bartonella henselae is persistent bacteremia in cats despite the presence of a vigorous host immune response. to understand better the long-term survival of b. henselae in cats, we examined the feline humoral immune response to b. henselae outer membrane (om) proteins in naturally and experimentally infected cats. initially, a panel of sera (n = 42) collected throughout north america from naturally infected cats was used to probe b. henselae total membranes to detect commonly recog ...	2004	15155610
recommendations for treatment of human infections caused by bartonella species.		2004	15155180
[microbial diagnosis with pcr will become clinically beneficial with a faster analysis].	pcr was introduced in 1985 by mullis and was immediately recognized as a valuable tool in biomedical research and was awarded the nobel prize in 1993. two culture-negative meningitis cases are described where haemophilus influenzae and neisseria meningitidis were found by 16srna-pcr. the modern real time pcr technology using fluorescent probes (hybridization probes, lightup probes, molecular beacons etc) for detection of the pcr-product or on dna microarray chips, is under development for routin ...	2004	15150950
host cell modulation by human, animal and plant pathogens.	members of the alpha-proteobacteria display a broad range of interactions with higher eukaryotes. some are pathogens of humans, such as rickettsia and bartonella that are associated with diseases like epidemic typhus, trench fever, cat scratch disease and bacillary angiomatosis. others like the brucella cause abortions in pregnant animals. yet other species have evolved elaborate interactions with plants; in this group we find both plant symbionts and parasites. despite radically different host ...	2004	15149019
exposure to feline and canine pathogens in bobcats and gray foxes in urban and rural zones of a national park in california.	exposure of bobcats (lynx rufus) and gray foxes (urocyon cinereoargenteus) to a range of common canine and feline pathogens was assessed in urban and rural zones of golden gate national recreation area, a national park in the san francisco bay area, (california, usa) from 1992 to 1995. testing included serology for canine distemper virus, canine parvovirus (cpv), canine adenovirus, leptospira interrogans, feline calicivirus (fcv), feline panleukopenia virus, feline herpesvirus, feline enteric co ...	2004	15137484
prevalence of bartonella infection in wild african lions (panthera leo) and cheetahs (acinonyx jubatus).	bartonella species are emerging pathogens that have been isolated worldwide from humans and other mammals. our objective was to estimate the prevalence of bartonella infection in free-ranging african lions (panthera leo) and cheetahs (acinonyx jubatus). blood and/or serum samples were collected from a convenience sample of 113 lions and 74 cheetahs captured in africa between 1982 and 2002. whole blood samples available from 58 of the lions and 17 of the cheetahs were cultured for evidence of bar ...	2004	15135511
chronic canine ehrlichiosis (ehrlichia canis): a retrospective study of 19 natural cases.	nineteen dogs from greece with chronic ehrlichiosis were studied. the dogs exhibited bicytopenia or pancytopenia, bone marrow hypoplasia, seroreactivity to ehrlichia canis (e. canis) antigens, and had no history of drug or radiation exposure. anorexia, depression, severe bleeding tendencies, hypoalbuminemia, and increased serum alanine aminotransferase activity were also hallmarks of the disease. all these animals eventually died, irrespective of the treatment applied. some dogs were also serolo ...	2004	15131097
clinical problem-solving. index of suspicion.		2004	15128900
cat scratch disease and other zoonotic bartonella infections.		2004	15112775
[a case of bartonella henselae infection from a dog].	a 50-year-old male with left cervical lymphadenopathy visited our hospital. infectious and lymphomatous diseases were suspected in the patient. since the patient owned a dog, which often licked the patient's face, bartonella infection was also suspected. histopathological examination in the lymph node biopsy revealed the epithelioid granuloma, but b. henselae was not detected from the culture of the lymphnode. b. henselae dna also was not detected from the lymph node. since the antibody titer (l ...	2004	15103910
prevalence and diversity of bartonella in rodents of northern thailand: a comparison with bartonella in rodents from southern china.	we report results of the first study to investigate the distribution and diversity of bartonella in rodents from thailand. whole blood from 195 rodents, representing six species, was tested for the presence of bartonella species using standard culture techniques. isolates were obtained from 17 (8.7%) of the samples, and 14 of those isolates represented distinct strains, based upon partial sequencing of the citrate synthase (glta) gene. phylogenetic analysis of the isolates and other bartonella s ...	2004	15100459
seroprevalence of bartonella infection in american free-ranging and captive pumas (felis concolor) and bobcats (lynx rufus).	bartonella henselae is the main agent of cat scratch disease in humans and domestic cats are the main reservoir of this bacterium. we conducted a serosurvey to investigate the role of american wild felids as a potential reservoir of bartonella species. a total of 479 samples (439 serum samples and 40 nobuto strips) collected between 1984 and 1999 from pumas (felis concolor) and 91 samples (58 serum samples and 33 nobuto strips) collected from bobcats (lynx rufus) in north america, central americ ...	2004	15099499
[cotton wool spots in a 16-year-old girl].		2005	15095109
bacillary angiomatosis with cytomegaloviral and mycobacterial infections of the palpebral conjunctiva in a patient with aids.	we report the clinical and histopathologic findings of bacillary angiomatosis involving the palpebral conjunctiva with concomitant infection by cytomegalovirus and mycobacterium species in a patient with acquired immune deficiency syndrome. after debulking, the conjunctival tissue was studied with the use of light and electron microscopy; stains for bacteria, acid-fast bacilli, and bartonella species; and immunohistochemical studies for cytomegalovirus and herpes simplex virus. we observed the t ...	2004	15083089
retinal and optic nerve neovascularization associated with cat scratch neuroretinitis.		2004	15076968