Publications

antibody response in the parotid fluid and serum of irus monkeys (macaca fascicularis) after local immunization with streptococcus mutans.	the antibody response of macaca fascicularis in parotid saliva and serum to local immunization by two routes with streptococcus mutans was studied and compared over 1 year. antibodies were titrated and classified by indirect immunofluorescent staining using specific antiglobulin conjugates. antiglucosyltransferase activity was assayed by an enzyme inhibition test. animals were immunized first by injecting formalin-killed bacterial cells and cell products subcutaneously into the vicinity of the f ...	1975	50286
bilateral projections from precentral motor cortex to the putamen and other parts of the basal ganglia. an autoradiographic study in macaca fascicularis.	by tracing radioactively labeled proteins transported by axonal flow, projections from area 4 to the ipsi- and contralateral neostriatum and claustrum were demonstrated in 7 monkeys. a reversed topographic organization was found on both sides for the corticoneostriatal and corticoclaustral projections. the most extensive terminal field could be observed in the putamen. in contrast, very few area 4 efferents seemed to terminate in the caudate nucleus. this suggests differential functions for the ...	1975	50112
disposition of flunisolide in the rat, mouse, dog, rhesus monkey, and cynomolgus monkey.	flunisolide (6 alpha-fluoro-11 beta, 16 alpha, 17 alpha, 21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide) administered as a single iv or oral dose to rats, mice, dogs, rhesus monkeys, and cynomolgus monkeys had a plasma t 1/2 of 1-3.5 hr and was eliminated mainly via the bile. after iv administration of 14c-labeled flunisolide, radioactivity was widely distributed into tissues and organs. the apparent volume of distribution of flunisolide in these five species was 3.0-8.0 liters/kg. a ...	1979	38078
delayed-onset pulmonary insufficiency in primates resuscitated from hemorrhagic shock.	forty-one unanesthetized cynomolgus monkeys were subjected to 2 hours of hemorrhagic hypotension at various mean arterial pressures (map) between 40 and 60 mm hg. resuscitation and maintenance of map were provided by lactated ringer's solution and homologous blood. thirty-eight per cent (57% of those surviving greater than 24 hours) developed a delayed-onset (18 to 24 hours) pulmonary insufficiency in spite of good urinary output, and which did not respond to furosemide. the group in which this ...	1979	36483
pharmacological studies on cs-430, a new psychotropic agent.	10-bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6(5h)-one (cs-430) is a new psychotropic drug and has the following properties. the compound showed sleep-inducing effect at both 0.2 and 5 mg/kg (p.o.) in cynomolgus monkeys or at 3 mg/kg (p.o.) in rats. cs-430 showed selective conflict attenuating in rats or anticonvulsant effects in mice. furthermore, cs-430 blocked non-discriminated (sidman) avoidance response without severe impairment of the motor function bu ...	1978	35173
plasmodium knowlesi in the marmoset (callithrix jacchus).	common marmosets were shown to be susceptible to plasmodium knowlesi malaria. the morphology of the parasite was indistinguishable from the observed in the natural host (macaca fascicularis) and the common laboratory model (macaca mulatta). a differential susceptibility to p. knowlesi was observed in the 8 marmosets studied. multiplication rates of parasites were variable over 24 h periods. five animals died of a fulminating infection within 12--17 days after challenge. three animals recovered s ...	1979	33359
semen preservation in macaca fascicularis.	semen was collected from adult male macaca fascicularis using a rectal probe for electro-ejaculation. the effect on sperm motility of varying semen extender egg yolk concentration, ph, glycerol concentration, and equilibration times of sperm with glycerol was examined. no significant difference was observed between motilities at extender egg yolk concentrations of 10% to 40%. progressive motility was significantly greater at ph 7.2 and 8.0 than at 5.8, 6.5, and 8.7 (p less than 0.05). glycerol c ...	1978	31513
the structure and function of acid proteases. vii. distribution and some properties of acid proteases in monkey tissues.	1. the distribution of acid protease activity in various tissues of japanese monkey (macaca fuscata fuscata) was investigated with hemoglobin as a substrate at ph 3.0. the activity per protein weight in crude extracts was highest in spleen and lung, and decreased in the order: spleen, lung greater than kidney, testis greater than brain greater than liver, placenta greater than thyroid gland, muscle. the activity in crude muscle extract was about one-tenth those of spleen and lung. the activity p ...	1977	14947
pneumococcal leptomeningitis in cynomolgus monkeys (macaca fascicularis).		1976	10668
perinephritis hypertension in monkeys. i. an increase of plasma renin activity associated with increased permeability of retinal vessels and angionecrosis.	the renal parenchyma of 5 crub-eating monkeys (macaca irus) was wrapped by cellophane, and plasma renin activity, blood pressure and vascular permeability of ocular ground were measured in comparison with 5 unoperated control monkeys. the results demonstrated that increases of systolic arterial pressure, plasma renin activity, and permeability of the retinal vessels were found in 4 operated monkeys. there was no such abnormal finding in the unoperated control monkeys. generally there was a rough ...	1976	6807
[dopamine of the caudate nucleus in perodictious potto, macaca mulatta and macaca fascicularis].	the dopamine, dopac and tyrosinehydroxylase contents of the caudate nucleus in the prosimian perodicticus potto and in the simii macaca mulatta and m. fascicularis have been estimated. the results do not support the hypothesis according to which the sluggishness of the potto is somehow related to a low dopamine content of part of the extrapyramidal system as found in the parkinson-syndrome.	1975	2371
experimental diarrhea in cynomolgus monkeys by oral administration with clostridium perfringens type a viable cells or enterotoxin.	purified c. perfringens type a enterotoxin fed orally in an amount of 5 mg caused both vomiting and diarrhea in the monkey only when the gastric juice had been neutralized. exposure of enterotoxin to ph 4.0 or below rapidly destroyed the activity. all three monkeys receiving sodium bicarbonate and 2.4 x 10(10) viable cells grown in ds medium developed diarrhea, and only one of them vomited once. the diarrhea lasted for 13, 18 and 19 hr. the symptoms were similar to those reported in human cases ...	1975	525
human and monkey prolactin and growth hormone: separation of polymorphic forms by isoelectric focusing.	the feasibility of using isoelectric focusing for the separation of primate pituitary growth hormone from prolactin and for the characterization of polymorphic forms of these hormones was explored. in a ph 3--10 gradient, extracts of both human and cynomolgus monkey pituitaries were each resolved into 4 growth hormone components and at least 3 prolactin components, as shown by radioimmunoassay. in narrower gradients (of 2--3 ph units) greater resolution was achieved; the principal growth hormone ...	1975	227