Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| comparison of micrococcus, bcg and related polysaccharides in the specific and non-specific immune resistance to murine l1210 leukemia [proceedings]. | 1978 | 81034 | |
| in-vitro immunological assay for diagnosis of coeliac disease. | 1978 | 76821 | |
| requirements for induction of delay hypersensitivity in the chicken. | 1978 | 76579 | |
| the use of two-dimensional immunoelectrophoresis for the characterization of antigens of bcg substrains. | the usefulness of the method of two-dimensional immunoelectrophoresis (2d-iep) in comparative studies and characterization of the antigenic spectra of various bcg substrains have been estimated. the bcg substrains used were: substrain bcg-rio de janeiro, substrain bcg-poland, form-rough (r) and substrain bcg-poland, form-smooth (s). the 2d-iep technique was found to give characteristic immunoelectrophoretic patterns of antigenic composition of the different bcg substrains. the number of precipit ... | 1978 | 76422 |
| an attempt at the use of immunological methods for the detection of enzymes of bcg substrains. | immunological methods have been used to visualize peroxidase and dehydrogenase activities of substrains of bcg mycobacteria. immunodiffusion (id) and immunoelectrophoresis (ie) in agar gel and two-dimensional immunoelectrophoresis (2d-ie) in agarose gel were employed. in all these tests part of the id, ie, and 2d-ie preparations were stained with amido black 10b (ab 10b) to visualize the total number of precipitin lines and part were stained at the same time with histochemical methods for vizual ... | 1978 | 76421 |
| stimulation and inhibition of macrophages prior to immunization with a hapten-carrier conjugate. | delayed hypersensitivity reactions and antibody-mediated reactions to the carrier and to the hapten have been studied in animals treated with bcg or/and trypan blue before immunization with a hapten-carrier complex. the results show that it is possible to induce, with bcg, at the beginning of the response, an antigenic competition between hapten and carrier moieties of the antigen molecule. macrophages which modulate the response to the hapten-carrier complex by acting both on t cells involved i ... | 1977 | 75840 |
| macrophage disappearance reaction in rana esculenta induced by specific antigen and rabbit lymphokines. | macrophage disappearance reaction was induced by intraperitoneal injections of specific antigens in rana esculenta sensitized by bovine gamma globulin and mycobacterium bovis bcg. rabbit lymphokines derived from concanavalin a stimulated blood lymphocytes injected intraperitoneally were able to induce macrophage disappearance reaction in normal rana esculenta. this suggests that mammalian lymphokines are capable of acting in amphibia. mammalian lymphokines have not an exclusive class-specificity ... | 1977 | 73345 |
| precipitation of radiolabeled antigen-antibody complexes with protein a-containing staphylococcus aureus. | the feasibility of using protein a-containing staphylococcus aureus to measure antibodies in sera from several mammalian species was studied. a variety of unrelated radiolabeled antigens were tested, including components of bovine serum, dna, and bacterial and tumor-associated extracts. the use of s. aureus was found to be a reliable way to detect and measure the primary interactions between many of the antigens and antibodies tested. results were equivalent under many circumstances to those obt ... | 1977 | 68969 |
| transfer of delayed hypersensitivity in mice to microbial antigens with dialyzable transfer factor. | dialyzable lawrence-type transfer factor was prepared from the spleen cells of cf1 mice inoculated with coccidioides immitis- and candida albicans-killed vaccines and with live mycobacterium tuberculosis vaccine (bcg). these preparations were shown to transfer antigen-specific cell-mediated immunity to naive mice, as measured by the delayed skin test and footpad-swelling methods. reactivity could be demonstrated when the test antigens were given 24 h after the transfer factor, but not when they ... | 1977 | 68930 |
| use of sepharose-conjugated bcg antibodies for the purification of tuberculin-active components. | bacillus calmette-guérin (bcg) antibodies conjugated with cnbr-activated sepharose 4b led to the isolation of tuberculin-active components from the protoplasmic materials of bcg. from these results; it is concluded that most of the tuberculin-active components (sensitins) have mycobacterial antigenic properties. | 1977 | 68806 |
| experimental cancer immunotherapy: modification of tumor cells to increase immunogenicity. | firmly established transplantable c3h/hej mammary carcinomas can be inhibited by host challenge with vibrio cholerae neuraminidase (vcn)-treated tumor cells. the effect is totally immunospecific, even vcn-treated tumors bearing shared mammary tumor virus (mtv) antigen cannot induce the regression. thus, vcn is capable of increasing the immunogenicity of the private, unique-unshared tumor antigens on mammary carcinomas; vcn is incapable of increasing the immunogenicity of the shared mtv-associate ... | 1976 | 68699 |
| the effects of certain immunity systemic advuvants, pha, and human gamma globulin on the thymic cortex of mice: a light and electron microscope study. | thymus of (c57bl/6 x dba/2) f1 mice was examined histologically, histochemically and ultrastructurally, seven days after intravenous injection of bcg, pertussis vaccine, lipopolysaccharide or human gamma globulin, or intraperitoneal injection of complete or incomplete freund's adjuvants or of phytohemagglutinin. only bcg induced a marked increase of the secretory activity of the thymic epithelium at all histological sites (cortex, corticomedullary junction and medullar). only with this adjuvant ... | 1976 | 66071 |
| immunological and other laboratory studies of patients receiving short-term cimetidine therapy. | 1977 | 64654 | |
| the effects of bcg on both cellular and humoral immunity during the early response to a hapten carrier complex. | cell-mediated reactions to the carrier and antibody-mediated reactions to hapten and carrier were studied in guinea-pigs treated with a single i.v. injection of bcg at different intervals of time before immunization with two different doses of a hapten-carrier complex. the results clearly show that bcg-induced delayed hypersensitivity reactions to the carrier and decreased antibody synthesis to the hapten. it is proposed that bcg acts on a dispatcher cell which controls both cellular and humoral ... | 1976 | 63343 |
| a system for the examination of tubercle bacilli and other mycobacteria. | methods are described for the examination of mycobacteria cultured from clinical specimens. in the "screening" procedure used for new isolates tubercle bacilli are non-pigmented, do not grow at 25 degrees c and are sensitive to p-nitrobenzoic acid as well as normally to anti-tuberculosis drugs. classification is extended when necessary by the use of four tests--temperature requirements, pigmentation, oxygen preference and tween hydrolysis. these define 15 species or groups meeting the needs of c ... | 1976 | 62439 |
| [adjuvant immunotherapy with bcg for malignant brain tumors (author's transl)]. | 1976 | 62316 | |
| chemotherapy of gastrointestinal cancer. | 1975 | 61195 | |
| peroxidase staining in elicited and nonelicited mononuclear peritoneal cells from bcg-sensitized and nonsensitized mice. | the peroxidase (po) activity in nonelicited macrophages and in casein-elicited monocytes, obtained from peritoneal cavities of nonsensitized and bcg-sensitized mice and cultivated on glass for 1 or 2 h, was studied by light and electron microscopy, using the 3,3'-diaminobenzidine technique. these two types of glass-adherent peritoneal cells differed in po activity. in macrophages, po activity was predominantly in the nuclear envelope, rough endoplasmic reticulum, and occasionally in vesicles of ... | 1976 | 61177 |
| specificity of antigenic fractions of tuberculin. | purified protein derivative from mycobacterium bovis was separated into 6 fractions by electrophoresis at 1500 v/40 ma in ph 4.2 acetic acid-pyridine buffer. further purification of one of the fractions on sephadex g 25 column and by acid hydrolysis yielded antigen "ps" eliciting tuberculin reaction only in animals vaccinated with m. bovis bcg but not in those sensitized with m. avium and some fast-growing mycobacteria. the specificity of antigen "ps" was confirmed in vitro: the antigen induced ... | 1976 | 59518 |
| shared antigens between human malignant melanoma cells and mycobacterium bovis (bcg). | this study was undertaken to investigate the antigenic relationships between human malignant melanoma cells and mycobacterium bovis (bcg). rabbits were immunized with sonicates of bcg or with malignant melanoma cells from different patients and the resulting antisera were tested for their capacity to bind radiolabeled soluble extracts prepared from bcg and melanoma cells. the binding of antibodies to radiolabeled antigens was studied by precipitation of radiolabeled antigen-antibody complexes by ... | 1976 | 58033 |
| partial purification of a serum factor that causes necrosis of tumors. | tumor necrosis can be induced in transplanted mouse methylcholanthrene-induced sarcoma by a tumor necrosis factor in the serum of mice infected with bacillus calmette-guérin and given bacterial endotoxin. sera from normal mice, endotoxin-treated mice, and mice infected with bacillus calmette-guérin do not contain this factor. a 20- to 30-fold purification of the serum factor has been achieved by (nh4)2so4 fractionation, sephadex g-100 and g-200 gel filtration, and preparative polyacrylamide elec ... | 1976 | 54919 |
| [the complement fixation test with bcg in the diagnosis of leishmaniasis]. | the utility of complement-fixation test with an antigen from commercially lyophilized bcg was investigated in the diagnosis of leishmaniasis. the following results were obtained: visceral leishmaniasis: 4 positivity on 5 cases; oriental sore: 3 positivity on 6 cases; canine leishmaniasis: 6 positivity, at high level, and 2 negativity; other diseases: 5 positivity, on 17 sera of tbc; no positivity in sera from patients with various diseases, in control and in normal dogs. the results are compared ... | 1975 | 54183 |
| multiple in vitro mechanisms of tumor cytotoxicity demonstrated in the line-1 guinea pig hepatoma model. | the line-1 guinea pig hepatoma was used to study in vitro tumor cytotoxicity. cytotoxicity was determined by measurement of the loss of tritiated thymidine-labeled target cells from culture vessels. with this technique, we demonstrated that significant tumor cytotoxicity was caused by lymphoid cells from tumor-immune guinea pigs, by cells from guinea pigs immunized against an antigen urelated to the tumor target, and by cell-free supernatants rich in lymphocyte mediators. addition of normal peri ... | 1975 | 52720 |
| editorial: bovine tuberculosis and badgers. | 1975 | 50520 | |
| the immunological aspects of malignant disease. | 1975 | 49889 | |
| effect of infection with trichinella spiralis and bcg on thymic histology. | the histology of mouse thymic tissue was examined following infection with trichinella spiralis and/or bcg. icr/cd-1 mice were orally infected with 200 t. spiralis 56 days preceding intravenous administration of 4x10-6 viable bcg. following assessment of delayed hypersensitive foot pad reactions to bcg, the mice were bled and sacrificed. the thymus was removed from each animal, fixed in 10% neutral buffered formalin, embedded in paraffin and cut in 4 mum sections. examination of serial sections ... | 1975 | 49304 |
| comparison of the specificity of human and bovine tuberculin ppf for testing cattle. 3. national trial in great britain. | a field trial on a country-wide basis was undertaken to compare the specificity for bovine tuberculosis of single and comparative tuberculin tests in cattle using either weybridge human or weybridge bovine ppd. the tests were made on 10,305 cattle in 179 herds distributed throughout all regions of england, scotland and wales. results showed that a comparative tuberculin test using avian ppd with either human or bovine ppd had a much higher efficiency than a single injection of mammalian tubercul ... | 1975 | 47752 |
| comparison of the specificity of human and bovine tuberculin ppd for testing cattle. 2. south-eastern england. | a tuberculin testing trial was carried out in eight counties of south-eastern england to compare the specificity for bovine tuberculosis of weybridge human ppd with that of rotterdam bovine ppd. the matching of these two tuberculins for potency in naturally infected cattle had already been established, the bovine ppd being approximately one-and-a-half times more potent than the human ppd per unit of weight. in 1110 cattle in 25 herds with histories of long-standing freedom from tuberculosis and ... | 1975 | 47751 |
| comparison of the specificty of human and bovine tuberculin ppd for testing cattle. 1--republic of ireland. | a tuberculin testing trial in cattle was carried out in the republic of ireland to compare the specificity for bovine tuberculosis of a human purified protein derivative (ppd) tuberculin (weybridge) with that of a bovine ppd (rotterdam), and to determine whether discrimination between specific and non-specific reactions to mammalian tuberculin is better with doses of tuberculins smaller than those traditonally used for testing cattle. tests were carried out in 510 cattle, 395 of which were shown ... | 1975 | 47750 |
| investigation into the relationship of m ulcerans to m. buruli and other mycobacteria. | the main characteristics of mycoplasma ulcerans are its remarkably distinct drug sensitivity pattern and its rather poor enzymatic activity. m. microti is clearly distinguishable from m. bovis and m. tuberculosis. some of the m. buruli strains appear to be identical with m. ulcerans, whereas others show similarity either to m. microti or to m. tuberculosis. it seems that m. buruli is not a legitimate species. | 1975 | 47730 |
| a possible relationship between delayed hypersensitivity and cell-mediated immunity. | 1975 | 47728 | |
| the effect of toxoplasma cell fractions and mycobacterial immunostimulants against virulent toxoplasma gondii in mice. | toxoplasma gondii tachyzoites were disrupted in a ribi cell fractionator and separated into cell walls and protoplasm by differential centrifugation. these products were used alone or combined with a mycobacterial glycolipid (p3) and injected either as oil-in-water emulsions or incorporated in freund's incomplete adjuvant. mice were vaccinated by intravenous or intradermal routes and challenged intraperitoneally with a highly virulent strain of toxoplasma gondii. a local granuloma formation was ... | 1979 | 44793 |
| activation of macrophages assessed by in vivo and in vitro tests. | 1979 | 44641 | |
| non-specific induction of increased resistance in mice to trypanosoma congolense and trypanosoma brucei by immunostimulants. | administration of the immunostimulants corynebacterium parvum, bacillus calmette-guérin (bcg) or bordetella pertussis prior to, or at the same time as, challenge with trypanosoma congolense significantly increased survival times in mice, both of trypano-susceptible (a/j) and trypano-resistant (c57bl) strains. the increased survival time was associated with significant alterations in parasitaemia, which included lengthening of the pre-patent period, a delay in the time taken to reach the first pe ... | 1979 | 44360 |
| interferon and cytotoxic factor (cytotoxin) released in the blood of mice infected with mycobacterium bovis bcg. i. enhanced production of interferon and appearance of cytotoxin stimulated by capsular polysaccharide of klebsiella pneumoniae or bacterial lipopolysaccharide. | interferon production stimulated by the active substance (neutral fraction) of the capsular polysaccharide of klebsiella pneumoniae (neutral cps-k) in bcg-infected mice was compared with that by bacterial lipopolysaccharide (lps). prior infection with bcg increased the responsiveness of mice to the lethal effect of neutral cps-k as well as to that of lps. associated with this, bcg-infected mice showed a markedly enhanced ability to produce interferon after stimulation not only by lps but also by ... | 1979 | 41163 |
| superoxide production in pulmonary alveolar macrophages and killing of bcg by the superoxide-generating system with or without catalase. | the superoxide production of bcg-infected and noninfected alveolar macrophages was measured by superoxide dismutase-inhibitable nitro blue tetrazolium reduction. the cells were incubated with or without cell-free bronchial lavage fluid (pulmonary washings). when control alveolar macrophages were infected by bcg, superoxide production was decreased markedly, probably due to bacterial cytotoxic factors. in contrast, the production of superoxide in alveolar macrophages exposed to pulmonary washings ... | 1979 | 37165 |
| antimycobacterial activity of lecithin-cholesterol liposomes in the presence of phospholipase a2. | tubercle bacilli were preincubated with lecithin-cholesterol liposomes to be subsequently exposed to phospholipase a2. after further incubation in the environment of acidic buffer, viable units in the final mixture were enumerated by inoculating the serial dilutions of an aliquot onto kirchner agar medium containing horse serum in 5%. another aliquot was used for lipid analyses to confirm hydrolysis of lecithin. in addition to this bactericidal type of experiments, bacteriostatic tests were also ... | 1978 | 32413 |
| effect of immunomodulators on thymocyte suppressive activity in mice. | 1978 | 28950 | |
| studies on antituberculotic action of some phenothiazine derivatives in vitro. | five phenothiazine derivatives (chlorpromazine, levomepromazine, diethazine, promethazine and chlorpromazine) sulphoxyde were tested for antimycobacterial activity. the growth of mycobacterium tuberculosis, m. bovis and m. butyricum was inhibited by chlorpromazine practically at identical concentrations. the minimum inhibitory concentrations for m. tuberculosis were: chlorpromazine and levomepromazine, 10 microgram/ml; diethazine and promethazine 20 microgram/ml, whilst chlorpromazine sulphoxyde ... | 1977 | 24964 |
| of mice and men in bone marrow transplantation. | 1977 | 17189 | |
| graft-versus-host reaction-like phenomenon induced by bcg in mice lethally irradiated and transferred with syngeneic bone marrow cells. | 1977 | 16697 | |
| immunity to mycobacterium leprae infections in mice stimulated by m. leprae, bcg, and graft-versus-host reactions. | infections of mice with mycobacterium leprae in one rear foot pad immunized them against a second infection in the other rear foot pad. purified bacilli harvested from the first infection also produced immuniy when injection into the foot pads of previously uninfected mice. injections of bcg afforded similar protection, but had no adjuvant effect on m. leprae. m. duvali, a cultivable mycobacterium that is reported to be more closely related antigenically to m. leprae than bcg is, provided much l ... | 1976 | 11189 |
| purification of plasma membrane from bcg-induced rabbit alveolar macrophages. | 1976 | 7672 |