Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| genome-wide transcriptomic analysis of a superior biomass-degrading strain of a. fumigatus revealed active lignocellulose-degrading genes. | various saprotrophic microorganisms, especially filamentous fungi, can efficiently degrade lignocellulose that is one of the most abundant natural materials on earth. it consists of complex carbohydrates and aromatic polymers found in the plant cell wall and thus in plant debris. aspergillus fumigatus z5 was isolated from compost heaps and showed highly efficient plant biomass-degradation capability. | 2015 | 26076650 |
| deciphering chemokine properties by a hybrid agent-based model of aspergillus fumigatus infection in human alveoli. | the ubiquitous airborne fungal pathogen aspergillus fumigatus is inhaled by humans every day. in the lung, it is able to quickly adapt to the humid environment and, if not removed within a time frame of 4-8 h, the pathogen may cause damage by germination and invasive growth. applying a to-scale agent-based model of human alveoli to simulate early a. fumigatus infection under physiological conditions, we recently demonstrated that alveolar macrophages require chemotactic cues to accomplish the ta ... | 2015 | 26074897 |
| role of aspergillus fumigatus in triggering protease-activated receptor-2 in airway epithelial cells and skewing the cells toward a t-helper 2 bias. | aspergillus fumigatus (af) infection and sensitization are common and promote th2 disease in individuals with asthma. innate immune responses of bronchial epithelial cells are now known to play a key role in determination of t cell responses upon encounter with inhaled pathogens. we have recently shown that extracts of af suppress jak-stat signaling in epithelial cells and thus may promote th2 bias. to elucidate the impact of af on human bronchial epithelial cells, we tested the hypothesis that ... | 2016 | 26072921 |
| coccidioides endospores and spherules draw strong chemotactic, adhesive, and phagocytic responses by individual human neutrophils. | coccidioides spp. are dimorphic pathogenic fungi whose parasitic forms cause coccidioidomycosis (valley fever) in mammalian hosts. we use an innovative interdisciplinary approach to analyze one-on-one encounters between human neutrophils and two forms of coccidioides posadasii. to examine the mechanisms by which the innate immune system coordinates different stages of the host response to fungal pathogens, we dissect the immune-cell response into chemotaxis, adhesion, and phagocytosis. our singl ... | 2015 | 26070210 |
| aspergillus arthritis and organ transplantation. | we report a case of a kidney and pancreas transplanted patient, hospitalized for septic hip arthritis. the whole diagnostic work-up including synovial and bone biopsies remained negative. after inefficient empirical anti-bacterial antibiotic treatment, femoral head resection was performed and tissue analysis revealed aspergillus fumigatus hyphae. treatment with voriconazole along with hip replacement led to complete recovery. however, drug interaction between immunosuppressive and anti-fungal dr ... | 2012 | 26069774 |
| synthesis, characterization and biological activity of schiff bases based on chitosan and arylpyrazole moiety. | the schiff bases of chitosan were synthesized by the reaction of chitosan with 3-(4-substituted-phenyl)-1-phenyl-1h-pyrazole-4-carbaldehyde. the structure of the prepared chitosan derivatives was characterized by ft-ir spectroscopy, elemental analysis, and x-ray diffraction studies and thermogravimetric analysis (tg). the results show that the specific properties of schiff bases of chitosan can be altered by modifying the molecular structures with proper substituent groups.tg results reveal that ... | 2015 | 26067768 |
| an alternative host model of a mixed fungal infection by azole susceptible and resistant aspergillus spp strains. | aspergillus fumigatus is the most common mold involved in human infections. however, the number of non-fumigatus species able to cause disease is continuously increasing. among them, aspergillus lentulus is reported in hematological and cystic fibrosis patients and in those treated with corticosteroids. a. lentulus differs from a. fumigatus in some clinically relevant aspects such as virulence and antifungal susceptibility, showing high mics to most antifungals. previous studies proved that a. l ... | 2015 | 26065322 |
| a pharmacokinetic/pharmacodynamic analysis of a standard voriconazole regimen in different cyp2c19 genotypes by monte carlo simulation. | the objective of this study was to evaluate the standard voriconazole dosage regimen (maintenance dose was 200 mg bid orally) against aspergillus infections in different cyp2c19 genotypes from a pharmacokinetic/pharmacodynamic (pk/pd) perspective. | 2015 | 26062298 |
| microbial ecology of a crewed rover traverse in the arctic: low microbial dispersal and implications for planetary protection on human mars missions. | between april 2009 and july 2011, the nasa haughton-mars project (hmp) led the northwest passage drive expedition (nwpdx), a multi-staged long-distance crewed rover traverse along the northwest passage in the arctic. in april 2009, the hmp okarian rover was driven 496 km over sea ice along the northwest passage, from kugluktuk to cambridge bay, nunavut, canada. during the traverse, crew members collected samples from within the rover and from undisturbed snow-covered surfaces around the rover at ... | 2015 | 26060984 |
| structural insights into binding of the antifungal drug fluconazole to saccharomyces cerevisiae lanosterol 14α-demethylase. | infections by fungal pathogens such as candida albicans and aspergillus fumigatus and their resistance to triazole drugs are major concerns. fungal lanosterol 14α-demethylase belongs to the cyp51 class in the cytochrome p450 superfamily of enzymes. this monospanning bitopic membrane protein is involved in ergosterol biosynthesis and is the primary target of azole antifungal drugs, including fluconazole. the lack of high-resolution structural information for this drug target from fungal pathogens ... | 2015 | 26055382 |
| calcium-mediated induction of paradoxical growth following caspofungin treatment is associated with calcineurin activation and phosphorylation in aspergillus fumigatus. | the echinocandin antifungal drug caspofungin at high concentrations reverses the growth inhibition of aspergillus fumigatus, a phenomenon known as the "paradoxical effect," which is not consistently observed with other echinocandins (micafungin and anidulafungin). previous studies of a. fumigatus revealed the loss of the paradoxical effect following pharmacological or genetic inhibition of calcineurin, yet the underlying mechanism is poorly understood. here, we utilized a codon-optimized biolumi ... | 2015 | 26055379 |
| hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (mdn-0010). | fungal infections have increased dramatically in the last 2 decades, and fighting infectious diseases requires innovative approaches such as the combination of two drugs acting on different targets or even targeting a salvage pathway of one of the drugs. the fungal cell wall biosynthesis is inhibited by the clinically used antifungal drug caspofungin. this antifungal activity has been found to be potentiated by humidimycin, a new natural product identified from the screening of a collection of 2 ... | 2015 | 26055366 |
| the aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence. | septins are a conserved family of gtpases that regulate important cellular processes such as cell wall integrity, and septation in fungi. the requirement of septins for virulence has been demonstrated in the human pathogenic yeasts candida albicans and cryptococcus neoformans, as well as the plant pathogen magnaporthe oryzae. aspergillus spp. contains five genes encoding for septins (aspa-e). while the importance of septins aspa, aspb, aspc, and aspe for growth and conidiation has been elucidate ... | 2015 | 26051489 |
| first determination of azole resistance in aspergillus fumigatus strains carrying the tr34/l98h mutations in turkey. | aspergillus fumigatus is the most important etiological agent of invasive aspergillosis. recently, an increasing number of azole-resistant a. fumigatus isolates have been described in various countries. the prevalence of azole resistance was investigated in this study using our culture collection of a. fumigatus isolates collected between 1999 and 2012 from clinical specimens. seven hundred and forty-six a. fumigatus isolates, collected from 419 patients, were investigated. first, all isolates w ... | 2015 | 26048062 |
| the role of lox-1 in innate immunity to aspergillus fumigatus in corneal epithelial cells. | to determine the role of lectin-like oxidized low-density lipoprotein receptor 1 (lox-1) in corneal epithelial cells exposed to fungus. | 2015 | 26047046 |
| acute invasive pulmonary aspergillosis complicating allergic bronchopulmonary aspergillosis: case report and systematic review. | aspergillus fumigatus can cause a variety of pulmonary syndromes including allergic bronchopulmonary aspergillosis (abpa), chronic pulmonary aspergillosis and invasive pulmonary aspergillosis (ipa). occurrence of ipa and abpa in the same patient is rare as the risk factors for abpa and ipa are different. we describe a 45-year-old male with abpa treated with oral methylprednisolone and itraconazole, who developed acute respiratory failure secondary to ipa, a month later. the patient subsequently ... | 2015 | 26045286 |
| an evaluation of antifungal agents for the treatment of fungal contamination in indoor air environments. | fungal contamination in indoor environments has been associated with adverse health effects for the inhabitants. remediation of fungal contamination requires removal of the fungi present and modifying the indoor environment to become less favourable to growth. this may include treatment of indoor environments with an antifungal agent to prevent future growth. however there are limited published data or advice on chemical agents suitable for indoor fungal remediation. the aim of this study was t ... | 2015 | 26042369 |
| lysophospholipids from the guangxi sponge spirastrella purpurea. | four known (1-4) and two new (5 and 6) lysophospholipids were isolated from the sponge spirastrella purpurea from weizhou island, guangxi autonomous region, china. the structures of the new compounds (5 and 6) were elucidated by detailed spectroscopic techniques, including 1d and 2d nmr ((1)h and (13)c nmr, (1)h-(1)h cosy, hsqc, and hmbc) as well as mass spectrometry and optical rotation experiments. the known compounds (1-4) were identified by comparison of their spectroscopic data and specific ... | 2015 | 26037518 |
| genomic context of azole resistance mutations in aspergillus fumigatus determined using whole-genome sequencing. | a rapid and global emergence of azole resistance has been observed in the pathogenic fungus aspergillus fumigatus over the past decade. the dominant resistance mechanism appears to be of environmental origin and involves mutations in the cyp51a gene, which encodes a protein targeted by triazole antifungal drugs. whole-genome sequencing (wgs) was performed for high-resolution single-nucleotide polymorphism (snp) analysis of 24 a. fumigatus isolates, including azole-resistant and susceptible clini ... | 2015 | 26037120 |
| the role of syk signaling in antifungal innate immunity of human corneal epithelial cells. | fungal keratitis is a kind of intractable and sight-threatening diseases. spleen-tyrosine kinase (syk) is a non-receptor tyrosine kinase, which plays an important role in the signaling pathway of the receptors. in the current study, we investigate the expression and function of syk in human corneal epithelial cells with aspergillus fumigatus (a. fumigatus) infection. | 2015 | 26036769 |
| proteomic analyses reveal the key roles of brla and abaa in biogenesis of gliotoxin in aspergillus fumigatus. | the opportunistic human pathogenic fungus aspergillus fumigatus primarily reproduces by forming a large number of asexual spores (conidia). sequential activation of the central regulators brla, abaa and weta is necessary for the fungus to undergo asexual development. in this study, to address the presumed roles of these key developmental regulators during proliferation of the fungus, we analyzed and compared the proteomes of vegetative cells of wild type (wt) and individual mutant strains. appro ... | 2015 | 26032501 |
| sertraline enhances the activity of antimicrobial agents against pathogens of clinical relevance. | serotonin reuptake inhibitors were recently reported to possess antimicrobial potentials, potentiate activity of several antibiotics, reverse multidrug resistant phenotypes of bacteria and make them susceptible to previously resistant drugs. we investigated antimicrobial potentials of sertraline (sr) against atcc strains, clinical isolates of staphylococcus aureus, escherichia coli and pseudomonas aeruginosa alone and in-combination with seven antibiotics. antifungal activity was investigated ag ... | 2015 | 26029671 |
| direct transbronchial administration of liposomal amphotericin b into a pulmonary aspergilloma. | pulmonary aspergillomas usually occur in pre-existing lung cavities exhibiting local immunodeficiency. as pulmonary aspergillomas only partially touch the walls of the cavities containing them, they rarely come into contact with the bloodstream, which makes it difficult for antifungal agents to reach them. although surgical treatment is the optimal strategy for curing the condition, most patients also have pulmonary complications such as tuberculosis and pulmonary fibrosis, which makes this stra ... | 2014 | 26029520 |
| cytokines induce effector t-helper cells during invasive aspergillosis; what we have learned about t-helper cells? | invasive aspergillosis caused by aspergillus species (aspergillus fumigatus, a. flavus, and a. terreus) is life-threatening infections in immunocompromised patients. understanding the innate and adaptive immune response particularly t-helper cells (th-cells) against these aspergillus species and how the different sub-set of th-cells are regulated by differentiating cytokines at primary target organ site like lung, kidney and brain is of great significance to human health. this review focuses on ... | 2015 | 26029179 |
| the role of a phospholipase (pld) in virulence of purpureocillium lilacinum (paecilomyces lilacinum). | phospholipases are key enzymes in pathogenic fungi that cleave host phospholipids, resulting in membrane destabilization and host cell penetration. however, understanding the role of phospholipases on the virulence of the filamentous fungus purpureocillium lilacinum has been still rather limited. in this study, pld gene was characterized. it encodes the protein phospholipase d (pld) in p. lilacinum. this gene, 3303 bp open reading frame fragment (orf), encodes a protein of 1100 amino acids with ... | 2015 | 26026833 |
| prospective evaluation of azole resistance in aspergillus fumigatus clinical isolates in france. | several studies, especially in europe, have recently reported the emerging phenomenon of azole resistance in aspergillus fumigatus, but very few data are available in france. our study aimed to determine the resistance prevalence in a. fumigatus isolates recovered from clinical samples over a 1-year period in two university hospital centers. | 2015 | 26026171 |
| polymorphonuclear neutrophils and granulocytic myeloid-derived suppressor cells inhibit natural killer cell activity toward aspergillus fumigatus. | invasive aspergillosis is a devastating infectious disease in immunocompromised patients. besides neutrophils and macrophages, natural killer (nk) cells have recently emerged as important players in immunity to this infection. it was shown that nk cells comprise an essential role in the clearance of aspergillus fumigatus (a. fumigatus) in neutropenic but not in nonneutropenic mice. however, the antifungal activity of nk cells and their regulation have not been fully characterized. in this study, ... | 2015 | 26026170 |
| hsp70 and the cochaperone stia (hop) orchestrate hsp90-mediated caspofungin tolerance in aspergillus fumigatus. | aspergillus fumigatus is the primary etiologic agent of invasive aspergillosis (ia), a major cause of death among immunosuppressed patients. echinocandins (e.g., caspofungin) are increasingly used as second-line therapy for ia, but their activity is only fungistatic. heat shock protein 90 (hsp90) was previously shown to trigger tolerance to caspofungin and the paradoxical effect (i.e., decreased efficacy of caspofungin at higher concentrations). here, we demonstrate the key role of another molec ... | 2015 | 26014950 |
| use of principal factor analysis to generate a corn silage fermentative quality index to rank well- or poorly preserved forages. | to investigate corn silage fermentative quality, a principal factor analysis was carried out on a database consisting of 196 corn silages sampled from the core, lateral and apical parts of silo feed-out face and characterised by 36 variables. eleven principal factor components (pcs) were retained and interpreted. two pcs were related to chemical and digestibility variables; four pcs were characterised by end-products associated with clostridia, heterolactic, homolactic or aerobic fermentations; ... | 2016 | 26010065 |
| epidemiological aspect and common bacterial and fungal isolates from suppurative corneal ulcer in mymensingh region. | this prospective study was done to find out the epidemiological factors of suppurative corneal ulcer and the common causative bacterial and fungal isolates from the, patients with suppurative corneal ulcer in secondary and tertiary level hospital at mymensingh region. a total 100 samples of corneal scrapings were collected purposively from clinically diagnosed suppurative corneal ulcer patients from march 18, 2012 to march 17, 2013. out of the total 100 samples, bacterial species were 29(29%) ca ... | 2015 | 26007250 |
| synthesis, in-vitro antibacterial, antifungal, and molecular modeling of potent anti-microbial agents with a combined pyrazole and thiophene pharmacophore. | ethyl 5-acetyl-4-methyl-2-(phenylamino)thiophene-3-carboxylate (2) and there derivatives 3a-c, 4, 6a-c and 9a-f were synthesized. the structure of compound 2 was deduced by 1h-nmr, 13c-nmr, ft-ir, ms, microanalysis, and single-crystal x-ray crystallography. the compound crystallized in the monoclinic system, with space group p21/c and cell coordinates a = 8.5752(16) å, b = 21.046(4) å, c = 8.2941(12) å, β = 101.131(6)°, v = 1468.7(4) å3, and z = 4. compounds 2, 3a-c, 4, 5a-c and 9a-f were subjec ... | 2015 | 26007175 |
| prevalence and mechanism of triazole resistance in aspergillus fumigatus in a referral chest hospital in delhi, india and an update of the situation in asia. | aspergillus fumigatus causes varied clinical syndromes ranging from colonization to deep infections. the mainstay of therapy of aspergillus diseases is triazoles but several studies globally highlighted variable prevalence of triazole resistance, which hampers the management of aspergillosis. we studied the prevalence of resistance in clinical a. fumigatus isolates during 4 years in a referral chest hospital in delhi, india and reviewed the scenario in asia and the middle east. aspergillus speci ... | 2015 | 26005442 |
| strain differences in the immune mechanisms of resistance of immunocompetent rats to pulmonary aspergillosis. | although the relevance of genetically-based variations in susceptibility to pulmonary aspergillosis was shown in immunocompromised mice and is indicated in humans, there is virtually no information concerning variations in antifungal immune responses in resistant individuals. we have shown recently the relevance of proinflammatory cytokine (interferon-γ/ifn-γ and interleukin-17/il-17) responses in resistance to sublethal aspergillus fumigatus infection of non-suppressed dark agouti (da) rats (st ... | 2015 | 26004347 |
| the clinical presentations of pulmonary aspergillosis in children with cystic fibrosis - preliminary report. | pulmonary aspergillosis is a very serious complication in cystic fibrosis (cf) patients due to the great variety of its clinical presentations and the fact that it worsens the prognosis. we can distinguish the following: aspergillus colonization (ac), aspergillus infection (ai) and allergic bronchopulmonary aspergillosis (abpa). aspergillus colonization (ac) is defined as isolation of aspergillus spp. from 50% ormore sputum samples over six months to one year without observing deterioration in l ... | 2015 | 26003072 |
| material properties and antimicrobial activity of polyhydroxybutyrate (phb) films incorporated with vanillin. | polyhydroxybutyrate (phb) was produced by bacillus mycoides dfc 1, isolated from garden soil. antimicrobial (am) films of phb were prepared by incorporating vanillin (4-hydroxy-3-methoxybenzaldehyde) from 10 to 200 μg/g of phb. the films were assessed for antimicrobial activity against foodborne pathogens and spoilage bacteria comprising of escherichia coli, salmonella typhimurium, shigella flexneri, and staphylococcus aureus and fungi such as aspergillus flavus, aspergillus fumigatus, aspergill ... | 2015 | 26002697 |
| a facile synthesis of novel miconazole analogues and the evaluation of their antifungal activity. | four novel miconazole analogues (8-11) were synthetized and evaluated for activity against four filamentous fungi (mucor hiemalis, aspergillus fumigatus, trichosporon cutaneum, and rhizopus oryzae) and eight species of candida as yeast specimens. compounds 9 and 10 showed very good activity when evaluated in yeast (mic 0.112 and 0.163 μg/ml) compared to the reference compound, itraconazole (mic 0.067 μg/ml). the best antifungal activity in filamentous strains was shown by compound 9. hence compo ... | 2015 | 25989345 |
| prospective multicenter international surveillance of azole resistance in aspergillus fumigatus. | to investigate azole resistance in clinical aspergillus isolates, we conducted prospective multicenter international surveillance. a total of 3,788 aspergillus isolates were screened in 22 centers from 19 countries. azole-resistant a. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles. | 2015 | 25988348 |
| nationwide surveillance of azole resistance in aspergillus diseases. | aspergillus disease affects a broad patient population, from patients with asthma to immunocompromised patients. azole resistance has been increasingly reported in both clinical and environmental aspergillus strains. the prevalence and clinical impact of azole resistance in different patient populations are currently unclear. this 1-year prospective multicenter cohort study aimed to provide detailed epidemiological data on aspergillus resistance among patients with aspergillus disease in belgium ... | 2015 | 25987612 |
| cyp2c19*17 genetic polymorphism--an uncommon cause of voriconazole treatment failure. | we describe an immunosuppressed, 48-year-old male, allogeneic hematopoietic stem cell transplant recipient with severe graft-versus-host disease who developed invasive pulmonary aspergillus fumigatus infection 6 months after transplant. his lack of response to voriconazole and undetectable serum trough levels of the drug led us to establish that he had the uncommon cytochrome p450, cyp2c19*17 allele, which leads to a rapid metabolism of voriconazole but not of the other azole antifungals. we dis ... | 2015 | 25986028 |
| bio-harvesting and pyrolysis of the microalgae botryococcus braunii. | the microalgae botryococcus braunii is widely recognized as a potentially important biofuel-feedstock whose commercial exploitation is limited by difficulties with its cultivation and harvesting. in this study, two b. braunii strains, kossou-4 and overjuyo-3 were successfully cultured at a 500 l-scale for 60-days. harvesting by bio-flocculation with aspergillus fumigatus at an optimum ratio of 1:40 of fungus to microalgal culture resulted in up to 98% recovery of biomass in the two strains. ulti ... | 2015 | 25983230 |
| gliotoxin production by aspergillus fumigatus strains from animal environment. micro-analytical sample treatment combined with a lc-ms/ms method for gliotoxin determination. | in this study, gliotoxin production by aspergillus fumigatus strains from animal environment is studied. moreover, a rapid, easy and environment-friendly micro-analytical sample treatment procedure coupled with lc-ms/ms was applied for the determination of gliotoxin from a. fumigatus cultures. the ability of gliotoxin production by 143 strains was assayed in yeast extract sucrose agar, and 1 ml of chloroform was used for toxin extraction without further clean-up. mean recoveries at two spiking l ... | 2015 | 25982450 |
| tnf-related apoptosis-inducing ligand (trail) regulates midline-1, thymic stromal lymphopoietin, inflammation, and remodeling in experimental eosinophilic esophagitis. | eosinophilic esophagitis (eoe) is an inflammatory disorder of the esophagus defined by eosinophil infiltration and tissue remodeling with resulting symptoms of esophageal dysfunction. tnf-related apoptosis-inducing ligand (trail) promotes inflammation through upregulation of the e3 ubiquitin-ligase midline-1 (mid1), which binds to and deactivates the catalytic subunit of protein phosphatase 2ac, resulting in increased nuclear factor κb activation. | 2015 | 25981737 |
| prior in vitro exposure to voriconazole confers resistance to amphotericin b in aspergillus fumigatus biofilms. | triazoles are the mainstay of treatment for aspergillosis, although resistance to these antifungal agents may be associated with treatment failure. refractory infections often necessitate a switch to other antifungal agents, including amphotericin b (amb), although these infections may not resolve. the aim of this study was to investigate the effect of prior azole exposure on amb sensitivity in aspergillus fumigatus biofilms. it was hypothesised that sequential antifungal therapy has the potenti ... | 2015 | 25979638 |
| evolution of fungal populations in corn silage conserved under polyethylene or biodegradable films. | to identify cultivable filamentous fungi before ensiling, after silage conservation, in farm-silos covered with two different plastic films (polyethylene (pe) vs biodegradable (mb)), as well as after aerobic exposure of whole-crop corn silage. | 2015 | 25976243 |
| photodynamic activity of nanostructured fabrics grafted with xanthene and thiazine dyes against opportunistic fungi. | fungi are an important class of human pathogens for which considerable research has gone into defeating them. the photodynamic effects of rose bengal (rb), phloxine b (pb), azure a (aa), and toluidine blue o (tbo) dyes to inhibit aspergillus fumigatus, aspergillus niger, trichoderma viride, penicillium funiculosum, and chaetomium globosum were investigated grafted to nano- and micro-structured fabrics. three antifungal tests conducted: broth microdilution test of free dyes, zone of inhibition an ... | 2015 | 25972050 |
| activation of vitamin d regulates response of human bronchial epithelial cells to aspergillus fumigatus in an autocrine fashion. | aspergillus fumigatus (a. fumigatus) is one of the most common fungi to cause diseases in humans. recent evidence has demonstrated that airway epithelial cells play an important role in combating a. fumigatus through inflammatory responses. human airway epithelial cells have been proven to synthesize the active vitamin d, which plays a key role in regulating inflammation. the present study was conducted to investigate the impact of a. fumigatus infection on the activation of vitamin d and the ro ... | 2015 | 25960612 |
| bronchial myeloid sarcoma with concurrent aspergillus fumigatus infection in a patient presenting with hemoptysis. | myeloid sarcoma (ms) is an extramedullary myeloid neoplasm characterized by proliferation of myeloblasts which can occur in any organ or site. bronchial and pulmonary involvement, however, is uncommon. we describe a case of bronchial ms in an 81-year-old female with a history of high-grade myelodysplastic syndrome; she was started on treatment few months before, and she presented with fever, cough and profuse hemoptysis. she was found to be pancytopenic with bilateral airspace consolidations, mo ... | 2015 | 25959740 |
| co-recognition of β-glucan and chitin and programming of adaptive immunity to aspergillus fumigatus. | the prevalence of fungal infections has increased concurrently with increases in immune suppressive therapies and susceptible individuals. opportunistic fungal pathogens such as aspergillus fumigatus may exhibit invasive growth and dissemination resulting in a high mortality rate. herein, we discuss how immune sensing of germination directs innate immune responses and programs adaptive responses that could promote or impair immune protection during periods of heightened susceptibility. in infect ... | 2015 | 25954267 |
| assessment of microbial contamination within working environments of different types of composting plants. | the objective of the study was to determine the degree of microbiological contamination, type of microflora, bioaerosol particle size distribution, and concentration of endotoxins in dust in different types of composting plants. in addition, this study provides a list of indicator microorganisms that pose a biological threat in composting facilities, based on their prevalence within the workplace, source of isolation, and health hazards. we undertook microbiological analysis of the air, work sur ... | 2015 | 25947216 |
| an adenoviral vector encoding full-length dectin-1 promotes aspergillus-induced innate immune response in macrophages. | the incidence of invasive pulmonary aspergillosis (ipa) has increased significantly over the last two decades. alveolar macrophages (ams) represent the first line of pulmonary host response to aspergillus conidia. recognition of conidia by ams involves dectin-1 (clec7a), which is a conserved structure to combine β-glucans. the deficiency of dectin-1 results in impaired fungal killing and uncontrolled growth of aspergillus fumigatus. thus, we hypothesized that high expression of dectin-1 would en ... | 2015 | 25944256 |
| systematic global analysis of genes encoding protein phosphatases in aspergillus fumigatus. | aspergillus fumigatus is a fungal pathogen that causes several invasive and noninvasive diseases named aspergillosis. this disease is generally regarded as multifactorial, considering that several pathogenicity determinants are present during the establishment of this illness. it is necessary to obtain an increased knowledge of how, and which, a. fumigatus signal transduction pathways are engaged in the regulation of these processes. protein phosphatases are essential to several signal transduct ... | 2015 | 25943523 |
| glucocorticosteroids do not impact directly growth rate and biomass of rhizopus arrhizus (syn. r. oryzae) in vitro. | glucocorticoid (gc) use is a common risk factor for invasive fungal infections. this is attributed to the complex dysregulation of immunity caused by gcs. however, studies have demonstrated increased growth with gc exposure for some molds, such as aspergillus fumigatus and exserohilum rostratum. no such data exist for mucorales. therefore, we investigated the influence of gc exposure on the growth of rhizopus arrhizus (syn. r. oryzae) in different culture media and in different atmospheres. we m ... | 2015 | 25942104 |
| microbial communication leading to the activation of silent fungal secondary metabolite gene clusters. | microorganisms form diverse multispecies communities in various ecosystems. the high abundance of fungal and bacterial species in these consortia results in specific communication between the microorganisms. a key role in this communication is played by secondary metabolites (sms), which are also called natural products. recently, it was shown that interspecies "talk" between microorganisms represents a physiological trigger to activate silent gene clusters leading to the formation of novel sms ... | 2015 | 25941517 |
| environmental isolates of azole-resistant aspergillus fumigatus in germany. | azole antifungal drug resistance in aspergillus fumigatus is an emerging problem in several parts of the world. here we investigated the distribution of such strains in soils from germany. at a general positivity rate of 12%, most prevalently, we found strains with the tr34/l98h and tr46/y121f/t289a alleles, dispersed along a corridor across northern germany. comparison of the distributions of resistance alleles and genotypes between environment and clinical samples suggests the presence of loca ... | 2015 | 25941229 |
| trem-1 expression in rat corneal epithelium with aspergillus fumigatus infection. | to investigate the expression of triggering receptor expressed on myeloid cells-1 (trem-1) in the aberrant inflammation within the corneal epithelium at early period of fungal infection. | 2015 | 25938031 |
| the innate immune response to aspergillus fumigatus at the alveolar surface. | aspergillus fumigatus is an ubiquitous, saprophytic mould that forms and releases airborne conidia which are inhaled by humans on a daily basis. when the immune system is compromised (e.g. immunosuppressive therapy prior to organ transplantation) or there is pre-existing pulmonary malfunction (e.g. asthma, cystic fibrosis, tb lesions), a. fumigatus exploits weaknesses in the host defenses which can result in the development of saphrophytic, allergic or invasive aspergillosis. if not effectively ... | 2015 | 25934117 |
| the aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence. | aspergillus fumigatus is the most important airborne fungal pathogen, causing severe infections with invasive growth in immunocompromised patients. the fungal cell wall (cw) prevents the cell from lysing and protects the fungus against environmental stress conditions. because it is absent in humans and because of its essentiality, the fungal cw is a promising target for antifungal drugs. nowadays, compounds acting on the cw, i.e., echinocandin derivatives, are used to treat a. fumigatus infectio ... | 2015 | 25932027 |
| cxcr4+ granulocytes reflect fungal cystic fibrosis lung disease. | cystic fibrosis airways are frequently colonised with fungi. however, the interaction of these fungi with immune cells and the clinical relevance in cystic fibrosis lung disease are incompletely understood.we characterised granulocytes in airway fluids and peripheral blood from cystic fibrosis patients with and without fungal colonisation, non-cystic fibrosis disease controls and healthy control subjects cross-sectionally and longitudinally and correlated these findings with lung function parame ... | 2015 | 25929952 |
| epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes. | invasive aspergillosis (ia) is a fungal infection that particularly affects immunocompromised hosts. recently, several studies have indicated a high incidence of ia in intensive care unit (icu) patients. however, few data are available on the epidemiology and outcome of patients with ia in this setting. | 2015 | 25928694 |
| regulation of b-cell-activating factor expression on the basophil membrane of allergic patients. | to investigate the modulation of b-cell-activating factor (baff) expression on the basophil membrane of allergic patients. baff is an important regulator of b-cell activation, proliferation and immunoglobulin production, which may play a role in respiratory allergic diseases in promoting the production of ige by b cells. | 2015 | 25924578 |
| first description of azole-resistant aspergillus fumigatus due to tr46/y121f/t289a mutation in france. | azole resistance in aspergillus fumigatus is an emerging public health concern. recently, a novel fungicide-driven mutation in the cyp51a gene and its promoter, tr46/y121f/t289a, leading to high-level resistance to voriconazole has been identified in the netherlands, belgium, germany, denmark, tanzania, and india in both clinical and environmental samples. here we report the first description of a. fumigatus carrying this mutation in france, in a cystic fibrosis patient, underlining the need for ... | 2015 | 25918139 |
| azole-resistant aspergillosis. | azole-resistance in aspergillus fumigatus is emerging and is becoming an increasing problem in the management of aspergillosis. two types of development of resistance have been described; resistance acquired during azole treatment in an individual patient and through environmental exposure to fungicides. the main molecular mechanism of azole resistance in a. fumigatus is explained by mutations in the cyp51a-gene. the environmental route of resistance development is particularly worrying and may ... | 2015 | 25917808 |
| the aspergillus fumigatus sita phosphatase homologue is important for adhesion, cell wall integrity, biofilm formation, and virulence. | aspergillus fumigatus is an opportunistic pathogenic fungus able to infect immunocompromised patients, eventually causing disseminated infections that are difficult to control and lead to high mortality rates. it is important to understand how the signaling pathways that regulate these factors involved in virulence are orchestrated. protein phosphatases are central to numerous signal transduction pathways. here, we characterize the a. fumigatus protein phosphatase 2a sita, the saccharomyces cere ... | 2015 | 25911225 |
| [indoor fungal exposure: what impact on clinical and biological status regarding aspergillus during cystic fibrosis]. | the sources of exposure during diseases due to aspergillus fungi in cystic fibrosis patients are still poorly explored. we assessed home fungal exposure in patients suffering from cystic fibrosis and analysed its impact on the presence of aspergillus biological markers, the colonisation of airways, as well as the sensitization and aspergillus serology. between march 2012 and august 2012, 34 patients benefited from a visit performed by a home environment medical adviser including sampling for myc ... | 2015 | 25910711 |
| genetic analysis using an isogenic mating pair of aspergillus fumigatus identifies azole resistance genes and lack of mat locus's role in virulence. | invasive aspergillosis (ia) due to aspergillus fumigatus is a major cause of mortality in immunocompromised patients. the discovery of highly fertile strains of a. fumigatus opened the possibility to merge classical and contemporary genetics to address key questions about this pathogen. the merger involves sexual recombination, selection of desired traits, and genomics to identify any associated loci. we constructed a highly fertile isogenic pair of a. fumigatus strains with opposite mating type ... | 2015 | 25909486 |
| iron acquisition and oxidative stress response in aspergillus fumigatus. | aspergillus fumigatus is a ubiquitous airborne fungal pathogen that presents a life-threatening health risk to individuals with weakened immune systems. a. fumigatus pathogenicity depends on its ability to acquire iron from the host and to resist host-generated oxidative stress. gaining a deeper understanding of the molecular mechanisms governing a. fumigatus iron acquisition and oxidative stress response may ultimately help to improve the diagnosis and treatment of invasive aspergillus infectio ... | 2015 | 25908096 |
| amca-a putative mitochondrial ornithine transporter supporting fungal siderophore biosynthesis. | iron is an essential nutrient required for a wide range of cellular processes. the opportunistic fungal pathogen aspergillus fumigatus employs low-molecular mass iron-specific chelators, termed siderophores, for uptake, storage and intracellular iron distribution, which play a crucial role in the pathogenicity of this fungus. siderophore biosynthesis (sb) depends on coordination with the supply of its precursor ornithine, produced mitochondrially from glutamate or cytosolically via hydrolysis of ... | 2015 | 25904899 |
| high-level pan-azole-resistant aspergillosis. | high-level pan-azole-resistant aspergillus fumigatus was recovered from four patients with chronic lung disease. in one patient, the development of progressive resistance followed long-term azole therapy and switching between antifungal azoles. the high-level pan-azole-resistant phenotypes were not associated with a specific cyp51a gene mutation. new strategies that avoid the development of progressive azole resistance are needed. | 2015 | 25903576 |
| analytical and clinical evaluation of the pathonostics aspergenius assay for detection of invasive aspergillosis and resistance to azole antifungal drugs during testing of serum samples. | the commercially developed pathonostics aspergenius species assay is a multiplex real-time pcr capable of detecting aspergillosis and genetic markers associated with azole resistance. the assay is validated for testing bronchoalveolar lavage fluids, replacing the requirement for culture and benefiting patient management. application of this assay to less invasive, easily obtainable samples (e.g., serum) might be advantageous. the aim of this study was to determine the analytical and clinical per ... | 2015 | 25903571 |
| synthesis, biological evaluation and 2d-qsar study of halophenyl bis-hydrazones as antimicrobial and antitubercular agents. | in continuation of our endeavor towards the development of potent and effective antimicrobial agents, three series of halophenyl bis-hydrazones (14a-n, 16a-d, 17a and 17b) were synthesized and evaluated for their potential antibacterial, antifungal and antimycobacterial activities. these efforts led to the identification of five molecules 14c, 14g, 16b, 17a and 17b (mic range from 0.12 to 7.81 μg/ml) with broad antimicrobial activity against mycobacterium tuberculosis; aspergillus fumigates; gra ... | 2015 | 25903147 |
| antifungal susceptibilities of candida, cryptococcus neoformans and aspergillus fumigatus from the asia and western pacific region: data from the sentry antifungal surveillance program (2010-2012). | the sentry antifungal surveillance program monitors global susceptibility rates of newer and established antifungal agents. we report the in vitro activity of seven antifungal agents against 496 contemporary clinical isolates of yeasts and molds. the isolates were obtained from 20 laboratories in the asia-western pacific (apac) region during 2010 through 2012. anidulafungin, caspofungin, micafungin, fluconazole, itraconazole, posaconazole and voriconazole were susceptibility tested using clsi me ... | 2015 | 25899126 |
| multiple cyp51a-based mechanisms identified in azole-resistant isolates of aspergillus fumigatus from china. | seventy-two a. fumigatus clinical isolates from china were investigated for azole resistance based on mutations of cyp51a. we identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the tr34/l98h/s297t/f495i mutation, while one carries only the tr34/l98h mutation. to our knowledge, the latter has not been found previously in china. the fourth multiazole-resistant isolate (with only moderate itraconazole resistance) carrie ... | 2015 | 25896700 |
| optimization of polyene-azole combination therapy against aspergillosis using an in vitro pharmacokinetic-pharmacodynamic model. | although amphotericin b-azole combination therapy has traditionally been questioned due to potential antagonistic interactions, it is often used successfully to treat refractory invasive aspergillosis. so far, pharmacodynamic (pd) interactions have been assessed with conventional in vitro tests, which do not mimic human serum concentrations and animal models using limited doses. we therefore simulated the human serum concentration profiles of amphotericin b and voriconazole in an in vitro dialys ... | 2015 | 25896699 |
| long-term pulmonary infections in heart transplant recipients. | pulmonary infections are life-threatening complications in heart transplant recipients. our aim was to evaluate long-term pulmonary infections and the effect of prophylactic antimicrobial strategies on time of occurrence of pulmonary infections in heart transplant recipients. | 2015 | 25894190 |
| invasive pulmonary aspergillosis in heart transplant recipients. | invasive pulmonary aspergillosis is the most common invasive mycosis in heart transplant recipients. early clinical recognition of this complication is difficult and laboratory data is not specific. our aim was to study the characteristics of invasive pulmonary aspergillosis infections in heart transplant recipients. | 2015 | 25894189 |
| role of bronchoalveolar lavage in diagnosis of fungal infections in liver transplant recipients. | pulmonary fungal infections remain the most important cause of morbidity and mortality in liver transplant recipients. fast and accurate causative diagnoses are essential for a good outcome. bronchoscopy with bronchoalveolar lavage frequently is performed to diagnose pulmonary infections in immunocompromised patients. the aim of this study was to evaluate the diagnostic use of bronchoalveolar lavage in liver transplant recipients with pulmonary infections. | 2015 | 25894185 |
| the gβ-like protein cpcb is required for hyphal growth, conidiophore morphology and pathogenicity in aspergillus fumigatus. | cpcb (cross pathway control b) encodes a yeast cpc2 and mammalian rack1 (receptor for activated protein kinase c) ortholog, which is a wd repeat protein with functional homology to the β subunit of heterotrimeric g proteins in aspergillus fumigatus. previous study has reported that cpcb governs growth and development in both a. fumigatus and aspergillus nidulans. however, little is known about the functional identities of cpcb orthologs and their relationships with g protein complexes. in this s ... | 2015 | 25892048 |
| th17 cytokine deficiency in patients with aspergillus skull base osteomyelitis. | fungal skull base osteomyelitis (sbo) is a severe complication of otitis externa or sinonasal infection, and is mainly caused by aspergillus species. here we investigate innate and adaptive immune responses in patients with aspergillus sbo to identify defects in the immune response that could explain the susceptibility to this devastating disease. | 2015 | 25888308 |
| multi-triazole-resistant aspergillus fumigatus infections in australia. | the emergence of triazole resistance, including multi-triazole-resistant aspergillus fumigatus is being reported around the world, but there has been little evidence of this problem to date in australia. here we describe a retrospective search of antifungal susceptibility results of all australian clinical a. fumigatus isolates referred to the national mycology reference centre, adelaide, australia between 2000 and 2013, yielding 13 isolates with elevated minimum inhibitory concentrations to itr ... | 2015 | 25885568 |
| experimental study on cryotherapy for fungal corneal ulcer. | fungal corneal ulcer is one of the major causes of visual impairment worldwide. treatment of fungal corneal ulcer mainly depends on anti-fungal agents. in the current study, we developed an integrated combination therapy of cryotherapy and anti-fungal agents to facilitate effective treatment of fungal corneal ulcer. | 2015 | 25880872 |
| antibiosis interaction of staphylococccus aureus on aspergillus fumigatus assessed in vitro by mixed biofilm formation. | microorganisms of different species interact in several ecological niches, even causing infection. during the infectious process, a biofilm of single or multispecies can develop. aspergillus fumigatus and staphyloccocus aureus are etiologic agents that can cause infectious keratitis. we analyzed in vitro single a. fumigatus and s. aureus, and mixed a. fumigatus-s. aureus biofilms. both isolates were from patients with infectious keratitis. structure of the biofilms was analyzed through microscop ... | 2015 | 25880740 |
| mortality associated with avian reovirus infection in a free-living magpie (pica pica) in great britain. | avian reoviruses (arvs) cause a range of disease presentations in domestic, captive and free-living bird species. arvs have been reported as a cause of significant disease and mortality in free-living corvid species in north america and continental europe. until this report, there have been no confirmed cases of arv-associated disease in british wild birds. | 2015 | 25880683 |
| microbial diversity in bioaerosol samples causing odts compared to reference bioaerosol samples as measured using illumina sequencing and maldi-tof. | the importance of the microbial diversity of bioaerosols in relation to occupational exposure and work related health symptoms is not known. the aim of this paper is to gain knowledge on the bacterial and fungal communities in dust causing organic dust toxic syndrome (odts) and in reference dust not causing odts. bacterial and fungal communities were described in personal exposure samples from grass seed workers developing odts, in dust generated from grass seeds causing odts and in dust generat ... | 2015 | 25880607 |
| genetic manipulation of the pneumocandin biosynthetic pathway for generation of analogues and evaluation of their antifungal activity. | pneumocandins are lipohexapeptides of the echinocandin family that potently interrupt fungal cell wall biogenesis by noncompetitive inhibition of 1,3-β-glucan synthase. the pneumocandin biosynthetic gene cluster was previously elucidated by whole genome sequencing. in addition to the core nonribosomal peptide synthetase and polyketide synthase (glnrps4 and glpks4), the pneumocandin biosynthetic cluster includes two p450-type hemeprotein monooxygenase genes (glp450-1 and glp450-2) and four nonhem ... | 2015 | 25879325 |
| antifungal and antibacterial metabolites from a french poplar type propolis. | during this study, the in vitro antifungal and antibacterial activities of different extracts (aqueous and organic) obtained from a french propolis batch were evaluated. antifungal activity was evaluated by broth microdilution on three pathogenic strains: candida albicans, c. glabrata, and aspergillus fumigatus. antibacterial activity was assayed using agar dilution method on 36 gram-negative and gram-positive strains including staphylococcus aureus. organic extracts showed a significant antifun ... | 2015 | 25873978 |
| a fungal protease allergen provokes airway hyper-responsiveness in asthma. | asthma, a common disorder that affects >250 million people worldwide, is defined by exaggerated bronchoconstriction to inflammatory mediators including acetylcholine (ach), bradykinin and histamine-also termed airway hyper-responsiveness. nearly 10% of people with asthma have severe, treatment-resistant disease, which is frequently associated with immunoglobulin-e sensitization to ubiquitous fungi, typically aspergillus fumigatus (af). here we show that a major af allergen, asp f13, which is a s ... | 2015 | 25865874 |
| does use of the polyene natamycin as a food preservative jeopardise the clinical efficacy of amphotericin b? a word of concern. | natamycin is a poorly soluble, polyene macrolide antifungal agent used in the food industry for the surface treatment of cheese and sausages. this use is not of safety concern. however, highly soluble natamycin-cyclodextrin inclusion complexes have been developed for the protection of beverages. this practice leads to high drug exposures exceeding the safety level. apart from the definition of an acceptable daily dietary exposure to natamycin, its effect on the faecal flora as a reservoir for re ... | 2015 | 25862309 |
| allergic bronchopulmonary aspergillosis presenting as recurrent mass-like consolidation. | allergic bronchopulmonary aspergillosis (abpa) is a hypersensitive disease showing various radiographic and clinical manifestations. its clinical course has not been fully understood. here i describe a case of a 23-year-old immunocompetent man with frequently relapsing abpa. he was asthmatic. he visited our hospital because of a chronic cough. laboratory examination showed eosinophilia with increased total and aspergillus-specific ige as well as positive skin reaction to aspergillus fumigatus. r ... | 2015 | 25861349 |
| biodegradation of pesticides using fungi species found in the aquatic environment. | relatively limited attention has been given to the presence of fungi in the aquatic environment compared to their occurrence in other matrices. taking advantage and recognizing the biodegradable capabilities of fungi is important, since these organisms may produce many potent enzymes capable of degrading toxic pollutants. therefore, the aim of this study was to evaluate the potential ability of some species of filamentous fungi that occur in the aquatic environment to degrade pesticides in untre ... | 2015 | 25860553 |
| correction: the ph-responsive pacc transcription factor of aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. | [this corrects the article doi: 10.1371/journal.ppat.1004413.]. | 2015 | 25853727 |
| genome sequence comparison of aspergillus fumigatus strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis. | aspergillus fumigatus is the aspergillus species most commonly associated with aspergillosis. of the various presentations of aspergillosis, one of the most frequently observed in cases involving a. fumigatus pulmonary infections is aspergilloma (pa). in such infections one finds a fungus ball composed of fungal hyphae, inflammatory cells, fibrin, mucus, and tissue debris. chronic necrotizing pulmonary aspergillosis (cnpa), also known as semi-invasive or invasive aspergillosis, is locally invasi ... | 2015 | 25851262 |
| structure of n-myristoyltransferase from aspergillus fumigatus. | n-myristoyltransferase (nmt) is an enzyme which translocates the 14-carbon saturated fatty acid myristate from myristoyl-coa to the n-terminal glycine of substrate peptides. this myristoylation process is involved in protein modification in various eukaryotes, including animals and fungi. furthermore, this enzyme has been shown to be essential to the growth of various species, such as saccharomyces cerevisiae, which indicates that nmt is an attractive target for the development of a novel antifu ... | 2015 | 25849386 |
| antifungal properties of silver nanoparticles against indoor mould growth. | the presence of moulds in indoor environments causes serious diseases and acute or chronic toxicological syndromes. in order to inhibit or prevent the growth of microorganisms on building materials, the disruption of their vital processes or the reduction of reproduction is required. the development of novel techniques that impair the growth of microorganisms on building materials is usually based on silver nanoparticles (agnps). it makes them an alternative to other biocides. agnps have proven ... | 2015 | 25847174 |
| variable risk of atopic disease due to indoor fungal exposure in nhanes 2005-2006. | exposure to damp indoor environments is associated with increased risk of eczema, allergy and asthma. the role of dampness-related exposures and risk of allergic diseases are yet to be fully explored in the us population. | 2015 | 25845975 |
| atypical early aspergillus endocarditis post prosthetic mitral valve repair: a case report. | a 64-year-old female operated 1 month previous for mitral valve repair presented with acute respiratory distress and dyspnea. echocardiography showed large echogenic valvular mass measuring 2.3 × 1.3 cm with severe mitral regurgitation and dehiscence of the mitral ring posteriorly. the mass was attached subvalvularly to the ventricular septal-free wall and eroding through it, which required complete aggressive dissection of the infected tissues. diagnosis was confirmed after resection of the val ... | 2017 | 25838877 |
| calcium oxalate in the sputum may aid in the diagnosis of pulmonary aspergillosis: a report of two cases. | we present two cases of pulmonary aspergillosis in which calcium oxalate crystals in the sputum proved to be a useful diagnostic clue. in case 1, aspergillus hyphae was not identified; however, calcium oxalate crystals were present, and chronic necrotizing pulmonary aspergillosis was diagnosed. in case 2, calcium oxalate was detected and aspergillus fumigatus was identified later. thus, the presence of calcium oxalate in the sputum may be an important indicator for an a. fumigatus infection. | 2015 | 25834787 |
| characterization of the bioactive metabolites from a plant growth-promoting rhizobacteria and their exploitation as antimicrobial and plant growth-promoting agents. | a plant growth-promoting bacterial strain, pm 105, isolated from a tea plantation soil from the north eastern region of india was identified as pseudomonas aeruginosa through classical and 16s ribosomal dna (rdna) gene sequencing. further studies with this strain confirmed broad spectrum antifungal activity against ten human and plant pathogenic fungal pathogens viz. aspergillus flavus, aspergillus fumigatus, aspergillus niger, aspergillus tubingensis, candida albicans, colletotrichum gloeospori ... | 2015 | 25832181 |
| fungi in cystic fibrosis and non-cystic fibrosis bronchiectasis. | bronchiectasis is a pathologic bronchial dilatation with loss of function that can result from multiple inflammatory and infectious injuries to the conducting airways of the lung. molds, particularly the filamentous fungus aspergillus fumigatus, have been implicated as a common cause of both cystic fibrosis (cf) and non-cf bronchiectasis, the latter primarily in patients with severe asthma. the pathogenesis of mold-associated bronchiectasis is usually due to atopic sensitization to mold allergen ... | 2015 | 25826588 |
| exposures and health outcomes in relation to bioaerosol emissions from composting facilities: a systematic review of occupational and community studies. | the number of composting sites in europe is rapidly increasing, due to efforts to reduce the fraction of waste destined for landfill, but evidence on possible health impacts is limited. this article systematically reviews studies related to bioaerosol exposures within and near composting facilities and associated health effects in both community and occupational health settings. six electronic databases and bibliographies from january 1960 to july 2014 were searched for studies reporting on heal ... | 2015 | 25825807 |
| azole drug import into the pathogenic fungus aspergillus fumigatus. | the fungal pathogen aspergillus fumigatus causes serious illness and often death when it invades tissues, especially in immunocompromised individuals. the azole class of drugs is the most commonly prescribed treatment for many fungal infections and acts on the ergosterol biosynthesis pathway. one common mechanism of acquired azole drug resistance in fungi is the prevention of drug accumulation to toxic levels in the cell. while drug efflux is a well-known resistance strategy, reduced azole impor ... | 2015 | 25824209 |