Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| reaching women in the peruvian andes through cervical cancer screening campaigns: assessing attitudes of stakeholders and patients. | peru is characterized by high cervical cancer incidence and mortality rates. the country also experiences significant gaps in quality cervical cancer screening coverage for the population. | 2016 | 27799747 |
| exploring the use of oropharyngeal cancer histology to account for hpv status in population-based studies. | to assess whether poorly differentiated tumors and non-keratinizing tumors have similar demographic and clinical characteristics as human papilloma virus (hpv)-positive tumors in patients with oropharyngeal cancer. | 2016 | 27798923 |
| supporting human papillomavirus vaccination in adolescents: perspectives from commercial and medicaid health plans. | an estimated 79 million americans are infected with human papillomavirus (hpv). vaccination can reduce the burden of infection and hpv-associated cancers; yet, vaccination rates remain low. little is known about why some health plans achieve higher vaccination rates. | 2017 | 27798527 |
| experience of combined liquid based cervical cytology and high-risk hpv mrna for cervical cancer screening in thammasat university hospital. | cervical cancer is the second most common of malignancy found in thai women. human papillomavirus (hpv) infection is a major cause. the objective of the present study was to evaluate the prevalence of hpv infection and association with abnormal cervical cytology in thai women. | 2016 | 27797253 |
| lack of evidence for a relationship between high risk human papillomaviruses and breast cancer in iranian patients. | whether there is any relationship between human papilloma virus (hpv) and breast carcinoma is not clear. some previous studies have indicated a possible role in oncogenesis in the breast. in this study, we therefore analyzed the presence of hpv infection in breast tissues of iranian women from yazd city. | 2016 | 27797244 |
| silent high grade cervical intraepithelial neoplasia in atypical smears from liquid based cervical cytology - three years experience in thammasat university hospital. | to study the prevalence of cin2+ diagnosis in women with atypical papaniculoau (pap) smears to suggest appropriate management option for thai health care. | 2016 | 27797243 |
| the cellular dna helicase chlr1 regulates chromatin and nuclear matrix attachment of the human papillomavirus 16 e2 protein and high-copy-number viral genome establishment. | in papillomavirus infections, the viral genome is established as a double-stranded dna episome. to segregate the episomes into daughter cells during mitosis, they are tethered to cellular chromatin by the viral e2 protein. we previously demonstrated that the e2 proteins of diverse papillomavirus types, including bovine papillomavirus (bpv) and human papillomavirus 16 (hpv16), associate with the cellular dna helicase chlr1. this virus-host interaction is important for the tethering of bpv e2 to m ... | 2017 | 27795438 |
| otorhinolaryngology manifestations secondary to oral sex. | over the last few years, oral and pharyngeal signs and symptoms due to oral sex have increased significantly. however, no review articles related to this subject have been found in the medical literature. the objective of our study was to identify otorhinolaryngological manifestations associated with orogenital/oroanal contact, both in adults and children, in the context of consensual sex or sexual abuse. | 2016 | 27793330 |
| investigation of ezh2 pathways for novel epigenetic treatment strategies in oropharyngeal cancer. | in recent decades, the incidence of oropharyngeal squamous cell carcinoma (opscc) has been rising worldwide as a result of increasing oncogenic human papillomavirus (hpv) infections in the oropharynx. ezh2 is an epigenetic regulatory protein associated with tumor aggressiveness and negative survival outcomes in several human cancers. we aimed to determine the role of ezh2 as a potential therapeutic epigenetic target in hpv-positive and negative opscc. | 2016 | 27793210 |
| digital concentration readout of dna by absolute quantification of optically countable gold nanorods. | isolation and amplification procedures are indispensable for traditional single-molecule detection methods applied in low-abundance biomolecule analysis. here, we describe a method for ultrasensitive detection of dna through encoding a single target molecule with a single-countable nanometer-sized substitute (gold nanorod, aunr) and enrichment of the substitute aunrs into a limited region followed by accurate microscopic enumeration. the enrichment and the bright distinct color allow the aunrs t ... | 2016 | 27792306 |
| seborrheic keratosis-like lesions of the cervix and vagina: report of a new entity possibly related to low-risk human papillomavirus infection. | we report a series of 7 unusual and morphologically distinct cervical or upper vaginal lesions in women aged 41 to 70 years. the lesions involved the cervix in 3 cases, the upper vagina in 2, the cervix and vagina in 1, and in 1 case the site of origin could not be determined. the lesions had a consistent morphologic appearance with a surface "plaque-like" or "stuck-on" configuration apparent in those cases where surrounding normal tissues were present. broad coalescing solid sheets and intercon ... | 2017 | 27792064 |
| a comparative study of pulsed dye laser versus long pulsed nd:yag laser treatment in recalcitrant viral warts. | viral warts are common infectious skin disease induced by human papillomavirus (hpv). but the treatment of recalcitrant warts is still challenging. | 2016 | 27791434 |
| cervical cancer screening practices, knowledge of screening and risk, and highly active antiretroviral therapy adherence among women living with human immunodeficiency virus in lima, peru. | cervical cancer (cc) is the leading cause of cancer death among peruvian women. awareness shown by women living with hiv (wlhiv) of their increased risk and papanicoloau (pap) smear frequency is understudied, particularly in peru. we assessed the uptake of guidelines-based cc screening practices and its associations with two predictors, knowledge of cc screening and risk and highly active antiretroviral therapy (haart) adherence, among wlhiv. collected by self-administered questionnaires from 20 ... | 2017 | 27789849 |
| international trends in anal cancer incidence rates. | previous studies have reported rapid increases in anal cancer incidence rates in seven high-income countries in north america, europe and oceania. there is very limited information on whether this pattern is replicated in other parts of the world. in this study, we examine recent trends in anal cancer incidence in 18 countries worldwide. | 2016 | 27789668 |
| emerging viral stis among hiv-positive men who have sex with men: the era of hepatitis c virus and human papillomavirus. | the number of infectious disease outbreaks and the number of unique pathogens responsible have significantly increased since the 1980s. hiv-positive men who have sex with men (msm) are a vulnerable population with regards to the introduction, spread and clinical consequences of (newly introduced) stis. after the introduction of combination antiretroviral treatment (cart), the incidence of sexually acquired hepatitis c virus (hcv) infection and human papillomavirus (hpv)-induced anal cancers have ... | 2016 | 27789574 |
| safety of extending screening intervals beyond five years in cervical screening programmes with testing for high risk human papillomavirus: 14 year follow-up of population based randomised cohort in the netherlands. | 2016 | 27789534 | |
| [multiple epidermolytic acanthomas of the genitalia]. | epidermolytic hyperkeratosis presents a particular histological image common to several clinical pictures, including that of keratinopathic ichthyoses. it may also occur fortuitously in various tumoral and inflammatory lesions. it is the elementary histopathological lesion of epidermolytic acanthoma, which may either be single or multiple, and when it occurs in the genital area, is known as epidermolytic hyperkeratosis of the genitalia or multiple epidermolytic acanthoma of the genitalia. herein ... | 2017 | 27789051 |
| giant condyloma (buschke-loewenstein tumor) in a 16-year-old patient: case report. | the buschke-loewenstein tumor is characterized by excessive growth of verrucous lesions on the genitals and/or perianal region. it is considered benign despite the high rate of recurrence and the possibility of malignant transformation. it is commonly associated with subtypes 6 and 11 of the human papillomavirus (hpv), and host's immunity plays an important role in the development of the disease. surgical excision is the recommended treatment in most cases. we present the case of a 16 years old ... | 2016 | 27788531 |
| the role of cytology in the 21st century: the integration of cells and molecules. | cervical cancer screening test performance has been hampered by either a lack of sensitivity in pap cytology or a lack of specificity of human papillomavirus (hpv) testing. this is disturbing for patients and a cause of high costs for health care providers. | 2016 | 27788516 |
| oral human papillomavirus infection, sexual behaviors and risk of oral squamous cell carcinoma in southeast of china: a case-control study. | the causal association between human papillomavirus (hpv) and oral squamous cell carcinoma (oscc) remains controversial. most of previous studies did not consider the potential modification effect of sexual behaviors when evaluating the role of hpv infection in oscc risk. | 2016 | 27788480 |
| [prevalence of human papillomavirus infection and risk of cervical cancer or precancerous lesions in 15 years follow up: a prospective cohort study]. | objective: to evaluate the 15 years changing trends of prevalence of high risk hpv (hr-hpv) infection and the risks of cervical cancer and precancerous lesions (cin2+ ) among a chinese rural population. methods: the screening cohort with 1 997 women aged 35 to 45 years old was built in 1999 in xiangyuan county, shanxi province (spoccs-i) and followed up by cytology and hr-hpv testing in the years of 2005, 2010, and 2014. the changes of hr-hpv prevalence and the risks of cervical precancerous les ... | 2016 | 27784468 |
| next generation sequencing and its applications in hpv-associated cancers. | approximately 18% of all human cancers have a viral etiology, and human papillomavirus (hpv) has been identified as one of the most prevalent viruses that plays causative role in nearly all cervical cancers and, in addition, in subset of head and neck, anal, penile and vulvar cancers. the recent introduction of next generation sequencing (ngs) and other 'omics' approaches have resulted in comprehensive knowledge on the pathogenesis of hpv-driven tumors. specifically, these approaches have provid ... | 2017 | 27784002 |
| influence of il-6, il-8, and tgf-β1 gene polymorphisms on the risk of human papillomavirus-infection in women from pernambuco, brazil. | human papillomavirus (hpv) infections are strongly associated with the development of cervical intraepithelial neoplasias and invasive cervical cancer. polymorphisms in cytokine-encoding genes and behavioural cofactors could play an important role in protecting an individual against viral infections and cancer. here, we investigated whether il-6 -174 g>c, il-8 +396 g>t, and tgf-β1 +869 g>c and +915 g>c polymorphisms were associated with susceptibility to hpv infection in women from north-east (p ... | 2016 | 27783717 |
| clinical features and treatment outcomes of japanese head and neck cancer patients with a second primary cancer. | it has been well established that patients with head and neck cancer (hnc) have an elevated risk of developing a second primary cancer (spc), owing to the common carcinogenic risk factors, including tobacco and alcohol consumption, and inactive aldehyde dehydrogenase-2 genotype. here we investigated the current state of spc in japanese hnc patients. | 2016 | 27783469 |
| centers for disease control and prevention 2015 human papillomavirus vaccine recommendations for sexually assaulted patients: a review and update. | individuals who have been sexually assaulted are at risk for contracting human papillomavirus (hpv), the most common sexually transmitted infection. one of the best methods in protecting against contracting the hpv is to receive the hpv vaccine. to date, national sexual assault protocols and guidelines do not include information on hpv vaccination. the current 2015 centers for disease control and prevention has updated their recommendations for sexually assaulted patients to now receive the hpv ... | 2017 | 27782923 |
| hpv awareness, knowledge and vaccination attitudes among church-going african-american women. | the purpose of this exploratory study was to improve understanding of the sociodemographic correlates of human papillomavirus (hpv) awareness, knowledge, and vaccination attitudes in a convenience sample of church-going, african-american women and how knowledge about hpv-related cancers relates to vaccination attitudes for girls and boys. | 2016 | 27779945 |
| functional variant of the p2x7 receptor gene is associated with human papillomavirus-16 positive cervical squamous cell carcinoma. | human papillomavirus (hpv) infection and the fate of hpv infected cervical epithelial cells are strictly associated with cervical cancer development. p2x7 receptor has been implicated in both the regulation of immune responses and apoptosis of cervical cancer cells. the study aims to investigate if polymorphisms in the p2rx7 gene are associated with the risk of cervical cancer in taiwanese women. p2rx7 253 t/c, 835 g/a, and 1513 a/c loss-of-function polymorphisms were genotyped in a hospital-bas ... | 2016 | 27779103 |
| variation in human papillomavirus vaccine uptake and acceptability between female and male adolescents and their caregivers. | hpv vaccination coverage is suboptimal. previous research largely focused on vaccinating girls. this study aimed to identify factors associated with hpv vaccination among male and female adolescents. we conducted secondary analyses using the national immunization survey-teen. we specified parallel logistic models to examine associations of adolescent, caregiver, and provider characteristics with vaccination status among boys and girls. the primary outcome was hpv vaccination status defined as un ... | 2016 | 27778139 |
| design of a long-term follow-up effectiveness, immunogenicity and safety study of women who received the 9-valent human papillomavirus vaccine. | the 9-valent human papillomavirus (hpv) (9vhpv) vaccine targets four hpv types (6/11/16/18) also covered by the quadrivalent hpv (qhpv) vaccine and five additional types (31/33/45/52/58). vaccine efficacy to prevent hpv infection and disease was established in a phase iii clinical study in women 16-26years of age. a long-term follow-up (ltfu) study has been initiated as an extension of the phase iii clinical study to assess effectiveness of the 9vhpv vaccine up to at least 14years after the star ... | 2017 | 27777126 |
| pd-l1 expression in tonsillar cancer is associated with human papillomavirus positivity and improved survival: implications for anti-pd1 clinical trials. | in this study, we examined pd-l1 expression by immunohistochemistry in 99 patients with tonsillar cancer and known human papillomavirus (hpv) status to assess its clinical significance. we showed that the pattern of pd-l1 expression is strongly related to hpv status. the pd-l1 positivity rate was 83.3% in hpv-positive cases and 56.9% in hpv-negative cases (p < 0.05). patients with hpv-positive/pd-l1-positive cancer had significantly better event free survival and overall survival compared with p ... | 2016 | 27776338 |
| the epidemiologic status of gynecologic cancer in thailand. | between the years of 2010-2012, it was estimated there were a total of 112,392 new cases of cancers in thailand, thus, the total age-standardized rate (asr) per 100,000 is 137.6. in regards to the most prevalent types of cancer in female, breast cancer has the highest asr, followed by cervical cancer (asr=14.4); liver and bile duct cancer; colon and rectum cancer; trachea, bronchus and lung cancer; ovarian cancer (asr=6.0); thyroid cancer; non-hodgkin lymphoma and uterine cancer (asr=4.3). the t ... | 2016 | 27775261 |
| major clinical research advances in gynecologic cancer in 2015. | in 2015, fourteen topics were selected as major research advances in gynecologic oncology. for ovarian cancer, high-level evidence for annual screening with multimodal strategy which could reduce ovarian cancer deaths was reported. the best preventive strategies with current status of evidence level were also summarized. final report of chemotherapy or upfront surgery (chorus) trial of neoadjuvant chemotherapy in advanced stage ovarian cancer and individualized therapy based on gene characterist ... | 2016 | 27775259 |
| [human papillomavirus 16 e5 protein inhibits keratinocyte growth factor-triggered autophagy]. | objective to investigate the effect of e5 protein of human papillomavirus type 16 (hpv16 e5) on keratinocyte growth factor-triggered autophagy. methods firstly, pci-neo-e5 recombinant plasmid was constructed. after that, the recombinant plasmid harboring pci-neo-e5 was transfected into hacat cells using lipofectamine(tm)2000 reagent, and the mrna transcriptional level of 16 e5 was evaluated by quantitative real-time pcr (qrt-pcr). then, the expression of lc3biiwas detected by western blotting an ... | 2016 | 27774947 |
| intravaginal practices are associated with greater odds of high-risk hpv infection in haitian women. | haitian women have the highest incidence of cervical cancer within the western hemisphere. intravaginal hygiene practices have been linked with human papilloma virus (hpv) infection and cervical dysplasia. these practices, known as 'twalet deba' in haitian creole, are common among haitian women and are performed with various natural and synthetic agents. as part of a community-based participatory research initiative aimed at reducing cervical cancer disparities in rural haiti, we explored the us ... | 2017 | 27774794 |
| prevalence of human papillomavirus, epstein-barr virus, and cytomegalovirus in fine needle aspirates from lung carcinoma: a case-control study with review of literature. | oncogenic viruses have recently been allied with lung carcinoma, however, the causal association has not been established till date. the study was conducted to determine the prevalence of high-risk human papillomavirus (hpv; subtypes 16, 18, 31, 33 and 45), epstein-barr virus (ebv) and cytomegalovirus (cmv) in lung carcinoma using polymerase chain reaction (pcr) on fine needle aspirates. | 2016 | 27774746 |
| human papillomavirus in kidney transplant recipients. | human papillomavirus (hpv) is a common infection in kidney transplant recipients. hpv causes cervical, anal, vulvar, vaginal, penile and head and neck cancers. kidney transplant recipients have a disproportionate burden of disease given prolonged immunosuppression. given the long pre-invasive state of precancer lesions such as cervical intraepithelial neoplasia (cin) and anal intraepithelial neoplasia (ain) most hpv-cancers are preventable with screening and targeted treatment of disease. pre-tr ... | 2016 | 27772624 |
| proteomic analysis of the gamma human papillomavirus type 197 e6 and e7 associated cellular proteins. | gamma hpv197 was the most frequently identified hpv when human skin cancer specimens were analyzed by deep sequencing (arroyo muhr et al., int. j. cancer 136: 2546-55, 2015). to gain insight into the biological activities of hpv197, we investigated the cellular interactomes of hpv197 e6 and e7. hpv197 e6 protein interacts with a broad spectrum of cellular lxxll domain proteins, including ube3a and maml1. hpv197 e6 also binds and inhibits the tp53 tumor suppressor and interacts with the ccr4-not ... | 2017 | 27771561 |
| the effect of methylenetetrahydrofolate reductase polymorphisms on susceptibility to human papilloma virus infection and cervical cancer. | cervical cancer is the third most common cancer among women worldwide. several factors lead to cervical cancer, among which human papilloma virus (hpv) infection has a prominent role. methylenetetrahydrofolate reductase (mthfr) is crucial in folate metabolic pathway and plays an important role in dna synthesis and dna methylation. mthfr gene polymorphisms, including c677t and a1298c, lead to reduced enzyme activity. this case-control study aims to illustrate the association between mthfr gene po ... | 2016 | 27771518 |
| a direct detection of human papillomavirus 16 genomic dna using gold nanoprobes. | nanoparticles have been investigated as flagging tests for the sensitive dna recognition that can be utilized as a part of field applications to defeat restrictions. gold nanoparticles (aunps) have been widely utilized due to its optical property and capacity to get functionalized with a mixed bag of biomolecules. this study exhibits the utilization of aunps functionalized with single-stranded oligonucleotide (aunp-oligo test) for fast the identification of human papillomavirus (hpv). this test ... | 2017 | 27771413 |
| manufacturing costs of hpv vaccines for developing countries. | nearly all of the 500,000 new cases of cervical cancer and 270,000 deaths occur in middle or lower income countries. yet the two most prevalent hpv vaccines are unaffordable to most. even prices to gavi, the vaccine alliance, are unaffordable to graduating countries, once they lose gavi subsidies. merck and glaxosmithkline (gsk) claim their prices to gavi equal their manufacturing costs; but these costs remain undisclosed. we undertook this investigation to estimate those costs. | 2016 | 27771183 |
| felis catus papillomavirus type 2 e6 oncogene enhances mitogen-activated protein kinases and akt activation but not egfr expression in an in vitro feline model of viral pathogenesis. | a possible causative role of felis catus papillomavirus type 2 (fcapv2) in the development of feline oral and cutaneous squamous cell carcinomas (scc) has been recently suggested by demonstrating viral gene expression in vivo and transforming properties by its putative oncogenes e6 and e7 in vitro. the activated molecules mek (pmek), erk (perk) and akt (pakt) are signaling transduction effectors regulating cell proliferation and inhibition of apoptosis, which are critical steps towards tumour fo ... | 2016 | 27771077 |
| the rb binding domain of hpv31 e7 is required to maintain high levels of dna repair factors in infected cells. | human papillomaviruses (hpv) exhibit constitutive activation of atm and atr dna damage response (ddr) pathways, which are required for productive viral replication. expression of hpv31 e7 alone is sufficient to activate the ddr through an unknown mechanism. here, we demonstrate that the e7 rb binding domain is required to increase levels of many ddr proteins, including atm, chk2, chk1, the mrn components mre11, rad50, and nbs1, as well as the homologous recombination repair proteins brca1 and ra ... | 2017 | 27770701 |
| [categorization of uterine cervix tumors : what's new in the 2014 who classification]. | in the 2014 who classification, squamous cell precursor lesions are classified as low-grade and high-grade intraepithelial lesions. lsil corresponds to cin1, hsil includes cin2 and cin3. only adenocarcinoma in situ (ais) is accepted as precursor of adenocarcinoma and includes the stratified mucin-producing intraepithelial lesion (smile). although relatively rare, adenocarcinoma and squamous cell carcinoma can be mixed with a poorly differentiated neuroendocrine carcinoma. most cervical adenocarc ... | 2016 | 27770187 |
| vaccine development: from concept to early clinical testing. | in the 21st century, an array of microbiological and molecular allow antigens for new vaccines to be specifically identified, designed, produced and delivered with the aim of optimising the induction of a protective immune response against a well-defined immunogen. new knowledge about the functioning of the immune system and host pathogen interactions has stimulated the rational design of vaccines. the design toolbox includes vaccines made from whole pathogens, protein subunits, polysaccharides, ... | 2016 | 27769596 |
| [cervical cancer : update on morphology]. | the world health organization (who) classification from 2014 differentiates between different subtypes of mucinous adenocarcinoma of the uterine cervix. a gastric subtype was recently described that showed no association with high-risk human papillomavirus (hpv) infections, has a poor prognosis, is mainly diagnosed in women of asian origin and can occur in patients with peutz-jeghers syndrome. although no clear grading system has been recommended in the who classification, it is likely that grad ... | 2016 | 27766382 |
| keratinizing odontogenic cysts with a spectrum of verrucoid morphology: investigation of a potential role of human papillomavirus. | the role of human papillomavirus (hpv) in keratinizing odontogenic cysts (oc) has only rarely been studied. we describe the clinicopathologic findings in a series of ocs that had unusual keratinization patterns and were investigated for a possible hpv etiology. | 2016 | 27765332 |
| low prevalence of transcriptionally active human papilloma virus in indian patients with hnscc and leukoplakia. | in the present study, we comprehensively analyzed the prevalence of transcriptionally active human papilloma virus (hpv) in tissue samples of indian patients with leukoplakia, predominantly hyperplastic lesions and head and neck squamous cell carcinoma (hnscc). in addition, saliva samples from patients with hnscc were screened for hpv detection. | 2016 | 27765330 |
| hpv31 utilizes the atr-chk1 pathway to maintain elevated rrm2 levels and a replication-competent environment in differentiating keratinocytes. | productive replication of human papillomaviruses (hpv) is restricted to the uppermost layers of the differentiating epithelia. how hpv ensures an adequate supply of cellular substrates for viral dna synthesis in a differentiating environment is unclear. here, we demonstrate that hpv31 positive cells exhibit increased dntp pools and levels of rrm2, a component of the ribonucleotide reductase (rnr) complex, which is required for de novo synthesis of dntps. rrm2 depletion blocks productive replicat ... | 2016 | 27764728 |
| mirna expression profiles of hpv-infected patients with cervical cancer in the uyghur population in china. | the study aimed to investigate the state of human papillomavirus (hpv) infection in patients with cervical cancer in the uyghur population in china and to identify mirna as biomarker for cervical cancer and hpv infection. we also performed genotyping to determine the variation in the types of hpv. using microrna (mirna) microarray technology, differential mirna expression between hpv-infected cervical cancer and uninfected normal cervical tissues was determined; the microarray results were verif ... | 2016 | 27764149 |
| epidemiology of hpv genotypes among hiv positive women in kenya: a systematic review and meta-analysis. | there is a scarcity of data on the distribution of human papillomavirus (hpv) genotypes in the hiv positive population and in invasive cervical cancer (icc) in kenya. this may be different from genotypes found in abnormal cytology. yet, with the advent of preventive hpv vaccines that target hpv 16 and 18, and the nonavalent vaccine targeting 90% of all icc cases, such hpv genotype distribution data are indispensable for predicting the impact of vaccination and hpv screening on prevention. even w ... | 2016 | 27764092 |
| status of new vaccine introduction - worldwide, september 2016. | since the global expanded program on immunization (epi) was launched in 1974, vaccination against six diseases (tuberculosis, polio, diphtheria, tetanus, pertussis, and measles) has prevented millions of deaths and disabilities (1). significant advances have been made in the development and introduction of vaccines, and licensed vaccines are now available to prevent 25 diseases (2,3). historically, new vaccines only became available in low-income and middle-income countries decades after being i ... | 2016 | 27764083 |
| after a decade of human papillomavirus vaccination, how to bend the vaccination uptake curve upward. | 2017 | 27763949 | |
| parents who refuse or delay hpv vaccine: differences in vaccination behavior, beliefs, and clinical communication preferences. | we sought to estimate the national prevalence of hpv vaccine refusal and delay in a nationally-representative sample of parents of adolescents. we also compared parents who refused versus delayed hpv vaccine in terms of their vaccination beliefs and clinical communication preferences. | 2017 | 27763818 |
| evaluation of the vulvar cancer histology code reported by central cancer registries: importance in epidemiology. | -knowing the subtype of vulvar cancer histology is important for estimating human papillomavirus-related cancer etiology. surveillance of human papillomavirus-related vulvar cancers informs public health decisions related to vaccination against human papillomavirus. | 2017 | 27763794 |
| impact of human papilloma virus vaccination on adolescent knowledge, perception of sexual risk and need for safer sexual behaviors in bali, indonesia. | to determine the impact of human papilloma virus (hpv) vaccination on knowledge, perception of sexual risk and need for continued safe sexual behavior among indonesian girls. | 2016 | 27762471 |
| correlation between indoleamine 2,3 dioxygenase mrna and cdkn2a/p16 mrna: a combined strategy to cervical cancer diagnosis. | cervical cancer (cc) is one of the most common cancers among women worldwide. the relation of the human papillomavirus (hpv) with cc and its precursor lesions was first suspected for over 40 years. the indoleamine 2,3 dioxygenase (ido) is an immune modulator enzyme responsible for the immune system tissue protection mechanism, which may be the key to the tumoural persistence. hpv oncoprotein e7 promotes the increase in cyclin-dependent kinase inhibitor p16 (cdkn2a/p16). the isolated and combined ... | 2016 | 27761872 |
| promising new wart treatment: a randomized, placebo-controlled, clinical trial. | warts are common dermatological lesion caused by skin epithelial cells' infection with human papillomavirus (hpv). | 2016 | 27761268 |
| systematic comparison of different meta-analyses, systematic reviews and hta reports on cervical cancer screening based on cytology or hpv test. | introduction: cervical cancer screening programs all over the world are being radically revised; preventive screening is increasingly based on detecting infection with human papillomavirus (hpv). this change was driven by large international studies (comparing cytological and hpv-based screening), which were then summarized in systematic reviews or hta reports. we carried out a systematic comparison of these meta-analyses, comparing their contents, quality, results and recommendations. material ... | 2016 | 27761029 |
| distinctive distribution of hpv genotypes in cervical cancers in multi-ethnic suriname: implications for prevention and vaccination. | suriname is ranked as high-risk country for cervical cancer, but recent national data of hpv prevalence and distribution in cervical cancer is scarce. in a retrospective cross-sectional study, cervical cancer incidence, hpv prevalence and hpv-type-specific distribution were investigated in all cervical cancer cases (n = 111), diagnosed in two consecutive years. hpv presence and type-specific prevalence were determined in paraffin-embedded biopsies utilizing master-nested multiplex pcr assays, ta ... | 2017 | 27760573 |
| laryngopharyngeal reflux and herpes simplex virus type 2 are possible risk factors for adult-onset recurrent respiratory papillomatosis (prospective case-control study). | the human papillomavirus (hpv) causes recurrent respiratory papillomatosis (rrp). although hpv prevalence is high, the incidence of papillomatosis is low. thus, factors other than hpv infection probably contribute to rrp. this study investigated whether patients with papillomatosis are more often infected with herpes simplex virus type 2 and chlamydia trachomatis (cht) and whether laryngopharyngeal reflux (lpr) occurs in this group of patients more often. | 2016 | 27759910 |
| genome-wide profiling of the human papillomavirus dna integration in cervical intraepithelial neoplasia and normal cervical epithelium by hpv capture technology. | hpv integration plays an important role in cervical carcinogenesis. hpv genotypes and the exact integration sites were investigated using hpv capture technology combined with next generation sequencing in 166 women. three, one and six integration sites were verified in 7 hpv-positive 'normal cervical epithelium', 6 hpv-positive cin2 and 15 hpv-positive cin 3 samples, respectively. of the 10 integrations, one and nine were involved with hpv33 and hpv16, respectively. our study accurately evaluate ... | 2016 | 27759101 |
| [verrucae vulgares - clinical overview]. | 2016 | 27757862 | |
| impact of variations in triage cytology interpretation on human papillomavirus-based cervical screening and implications for screening algorithms. | women positive to human papillomavirus (hpv+) testing at cervical screening need triage, typically cytology and immediate colposcopy in case of atypical squamous cells of undetermined significance (ascus) or worse (ascus+) or, in cytology-normal hpv+ women, hpv test repeat after 1 year and colposcopy referral if still hpv+. our hypothesis was that substantial variations in triage positivity and sensitivity may produce little variation in overall referral to colposcopy and on sensitivity of the e ... | 2016 | 27755998 |
| treatment de-intensification strategies for head and neck cancer. | increasingly, squamous cell carcinoma of the oropharynx (opscc) is attributable to transformation resulting from high-risk human papillomavirus (hpv) infection. such cancers are significantly more responsive to treatment than traditional tobacco- and alcohol-associated squamous cell cancers of the head and neck. conventional management with definitive chemoradiation, surgery and adjuvant radiation, or radiation given with altered fractionation schemes, while effective, incurs long-term morbidity ... | 2016 | 27755996 |
| prevalence and risk factors of human papillomavirus infection in 18-year-old women: baseline report of a prospective study on human papillomavirus vaccine. | little is known about the epidemiology of human papillomavirus (hpv) in italy before the age of 25. at the european institute of oncology, a prospective observational study on cervical hpv infection in 18-year-old women undergoing quadrivalent hpv vaccination is ongoing. | 2017 | 27755229 |
| epidemiology of high-risk human papillomavirus and cervical lesions in african women living with hiv/aids: effect of anti-retroviral therapy. | to describe the effect of antiretroviral therapy (art) and hiv-related factors on high-risk human papillomavirus (hr-hpv) and high-grade cervical intraepithelial neoplasia lesions (cin2+) among women living with hiv/aids (wlha) in sub-saharan africa. | 2017 | 27755107 |
| optimal cervical cancer screening in women vaccinated against human papillomavirus. | current us cervical cancer screening guidelines do not differentiate recommendations based on a woman's human papillomavirus (hpv) vaccination status. changes to cervical cancer screening policies in hpv-vaccinated women should be evaluated. | 2017 | 27754955 |
| distribution of vaccine-type human papillomavirus does not differ by race or ethnicity among unvaccinated young women. | previous studies have demonstrated racial and ethnic differences in the distribution of human papillomavirus (hpv) types among adult women with cervical precancers. the aim of this study was to determine whether the distribution of vaccine-targeted hpv types varies by race/ethnicity among unvaccinated young women. | 2016 | 27754751 |
| human papillomavirus (hpv) awareness and vaccine receptivity among senegalese adolescents. | to examine hpv vaccine awareness and receptivity among adolescents and young adults in senegal. | 2017 | 27754581 |
| improving human papillomavirus vaccinations in military women. | the purpose of this evidence-based project was to provide patient education to increase human papillomavirus (hpv) vaccination rates in military women. despite the availability of a vaccine, hpv continues to be the most common sexually transmitted infection in the united states. the goal of this program was to increase patient knowledge and hpv vaccination rates by providing education and a verbal recommendation for vaccination during regularly scheduled well-woman exams. the project resulted in ... | 2016 | 27753556 |
| single and multiple high-risk and low-risk human papillomavirus association with cervical lesions of 11,224 women in jakarta. | we sought to evaluate prevalence, age-adjusted distribution, and impact of single and multiple high- and low-risk human papillomavirus (hpv) subtypes and their associations with cervical lesions. | 2016 | 27752850 |
| clinical and epidemiological study of human papillomavirus infection in women with systemic lupus erythematosus in eastern brazilian amazon. | cervical cancer, the second most common cancer affecting women in northern brazil, is strongly associated with human papillomavirus (hpv) infection. diseases affecting the immune state of a patient, including autoimmune diseases like systemic lupus erythematosus (sle), can lead to persistent hpv infection and cancer. we evaluated cervical hpv prevalence and the associated risk factors in 70 women with sle in the city of belém, located in brazilian amazon. hpv dna was detected by pcr using primer ... | 2017 | 27750272 |
| human papillomavirus 16 infection and tp53 mutation: two distinct pathogeneses for oropharyngeal squamous cell carcinoma in an eastern chinese population. | to investigate the clinicopathological characteristics, human papillomavirus (hpv) infection, p53 expression, and tp53 mutations in oropharyngeal squamous cell carcinoma (opscc) and determine their utility as prognostic predictors in a primarily eastern chinese population. | 2016 | 27749915 |
| increased growth of a newly established mouse epithelial cell line transformed with hpv-16 e7 in diabetic mice. | epidemiological evidence supports that infection with high-risk types of human papillomavirus (hpv) can interact with host and environmental risk factors to contribute to the development of cervical, oropharyngeal, and other anogenital cancers. in this study, we established a mouse epithelial cancer cell line, designated as chinese university papillomavirus-1 (cup-1), from c57bl/ksj mice through persistent expression of hpv-16 e7 oncogene. after continuous culturing of up to 200 days with over 6 ... | 2016 | 27749912 |
| genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer. | we conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from europe, north america and south america. we detected eight significantly associated loci (p < 5 × 10(-8)), seven of which are new for these cancer sites. oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, hla-dqb1), 10q26.13 (rs201982221, lhpp) and 11p15.4 (rs1453414, or52n2-trim5). oral cancer was associated with two new regions, 2p23.3 (rs6 ... | 2016 | 27749845 |
| anal intraepithelial neoplasia. | anal squamous cell cancer (scc) is a relatively uncommon cancer in the united states. anal scc has long been associated with human immunodeficiency virus (hiv) positivity and/or men who have sex with men. the incidence of anal scc has been increasing in both genders regardless of hiv status. few clinicians are aware that white women, when not controlling for gender and sexual preference together, have the highest incidence of anal scc. anal intraepithelial neoplasia (ain), dysplastic cells of th ... | 2017 | 27749636 |
| biological characterization of three immortalized esophageal epithelial cell lines. | the key molecular events that contribute to tumorigenesis are incompletely understood. the aim of the present study was to characterize and compare the biological phenotypes of three human telomerase reverse transcriptase (htert) and/or human papillomavirus 16 e6 and e7‑immortalized esophageal epithelial cell lines, ne2‑htert (ne2), ne3‑e6e7‑htert (ne3) and neca6‑e6e7‑htert (neca6). the present study used soft‑agar colony formation assays, tumorigenicity assays in nude mice, and cell proliferati ... | 2016 | 27748861 |
| multispectral autofluorescence imaging for detection of cervical lesions: a preclinical study. | the aim of this study was to develop a novel optical imaging system for detecting protoporphyrin ix (ppix) autofluorescence, to prove that ppix autofluorescence is as useful as 5-aminolevulinic acid (5-ala)-induced fluorescence for detecting and localizing cervical cancer, and to monitor the change in ppix autofluorescence or induced ppix fluorescence before, during, and after photodynamic therapy (pdt). | 2016 | 27748558 |
| awareness and knowledge of human papillomavirus (hpv), hpv-related cancers, and hpv vaccines in an uninsured adult clinic population. | human papillomavirus (hpv) vaccines offer primary prevention of cervical cancer and protection against other hpv-associated cancers. hpv vaccine coverage in the united states (u.s.) remains low, particularly among older adolescents/young adults, and the uninsured. we assessed awareness and knowledge of hpv disease, hpv-related cancers, and hpv vaccines among working, uninsured adults. data from the 2014 health information national trends survey (hints 4, cycle 4) were used as a benchmark. patien ... | 2016 | 27748078 |
| human papilloma viruses and breast cancer - assessment of causality. | high risk human papilloma viruses (hpvs) may have a causal role in some breast cancers. case-control studies, conducted in many different countries, consistently indicate that hpvs are more frequently present in breast cancers as compared to benign breast and normal breast controls (odds ratio 4.02). the assessment of causality of hpvs in breast cancer is difficult because (i) the hpv viral load is extremely low, (ii) hpv infections are common but hpv associated breast cancers are uncommon, and ... | 2016 | 27747193 |
| summary of emerging targets in anal cancer: the case for an immunotherapy based-approach. | squamous cell carcinoma of the anal canal (scca) remains a less common gastrointestinal malignancy despite a continued increase in the annual incidence in the united states and globally. the vast majority of all cases are attributed to persistent infection and integration into host cell dna by human papillomavirus (hpv). for patients with metastatic anal cancer, there is currently no accepted consensus standard of care. given the viral etiology associated with the oncogenesis of this tumor, grea ... | 2016 | 27747086 |
| beneficial effects of human papillomavirus vaccine for prevention of cervical abnormalities in miyagi, japan. | prevention of cervical cancer has been unsuccessful in japan because of low rates of cancer screening and vaccination. the vaccine adverse review committee of the japanese government investigated 2,475 adverse events and reported 617 (6.9/100,000) severe cases and 176 (2.0/100,000) cases with chronic pain. the proactive recommendation for human papillomavirus (hpv) vaccination has been suspended since june 2013. in this study, we examined vaccination rate and incidence of abnormal cervical cytol ... | 2016 | 27746423 |
| human papillomavirus vaccination and subsequent cervical cancer screening in a large integrated healthcare system. | human papillomavirus vaccination may result in lowered intention to be screened for cervical cancer, potentially leading to gaps in screening coverage and avoidable cervical cancer diagnoses. | 2017 | 27746152 |
| risk-factors and awareness of hpv in turkish people with anogenital warts in bagcilar district: a cross-sectional study. | anogenital warts (agws) are epithelial tumors which develop as a result of human papilloma virus (hpv) infection. we aimed to assess the sociodemographic, sexual and other possible risk-factors, and awareness of the hpv infection among turkish people with agw in the bagcilar district of istanbul. | 2016 | 27743437 |
| the use of telehealth to teach reproductive health to female rural high school students. | to evaluate the use of telehealth to teach reproductive health to rural areas with high rates of teen pregnancy. | 2017 | 27742427 |
| role of transoral robotic surgery in current head & neck practice. | morbidity and mortality associated with increasingly radical doses of chemoradiotherapy have led many to question the current standard of care in head and neck cancer. recently, surgeons have developed minimally invasive, transoral techniques which have demonstrated excellent survival and favourable functional outcomes. transoral robotic surgery (tors) is the most recent, cutting edge in the evolution of transoral techniques; tors allows surgeons unprecedented access to and visualisation of the ... | 2016 | 27742406 |
| improvement of gynecological screening of female renal transplant recipients by self-sampling for human papillomavirus detection. | female renal transplant recipients (rtrs) have increased risk for developing human papillomavirus (hpv)-related (pre)malignancies of the lower genital tract. annual cervical screening is advised for rtrs, but the participation rate is low. the aim of this study is to investigate whether hpv self-sampling is suitable for gynecological screening of rtrs to increase participation rate. | 2017 | 27741039 |
| usefulness of p16(ink4a) staining for managing histological high-grade squamous intraepithelial cervical lesions. | p16(ink4a) (p16) tumor-suppressor protein is a biomarker of human papillomavirus (hpv) oncogenic activity that has revealed a high rate of positivity in histological high-gade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 2 (hsil/cin2) lesions. however, there is a paucity of data regarding p16 status as a surrogate marker of hsil/cin2 evolution. the aim of this study was to evaluate the outcome of hsil/cin2 patients followed up without treatment for 12 months according ... | 2017 | 27739439 |
| [nomenclature of squamous cell precursor lesions of the lower female genital tract : current aspects]. | the majority of precancerous lesions of the lower female genital tract (intraepithelial neoplasia, in) are caused by human papillomavirus (hpv) infections resulting in cellular atypia and in turn an altered tissue architecture. depending on the pathogenesis, a distinction is made between vulvar intraepithelial neoplasia (vin) classified as classical vin associated with high-risk hpv infections (u-vin) and differentiated vin (d-vin), which is associated with lichen sclerosus et atrophicus and p53 ... | 2016 | 27738814 |
| risk of delayed human papillomavirus vaccination in inner-city adolescent women. | uptake of human papillomavirus (hpv) vaccine in the united states is slow, and the effectiveness of the vaccine has not been assessed in high-risk adolescent populations. | 2016 | 27738056 |
| experiences and lessons learned from 29 hpv vaccination programs implemented in 19 low and middle-income countries, 2009-2014. | cervical cancer is the greatest cause of age-weighted years of life lost in the developing world. human papillomavirus (hpv) infection is associated with a high proportion of cervical cancers, and hpv vaccination may help to reduce the incidence of cancer. the aim of the study was to identify barriers, obstacles, and strategies and to analyze key concerns and lessons learned with respect to the implementation of hpv vaccination program in low- and middle-income countries. | 2016 | 27737666 |
| a comparison of prognostic ability of staging systems for human papillomavirus-related oropharyngeal squamous cell carcinoma. | the current american joint committee on cancer/union for international cancer control (ajcc/uicc) staging system, developed for human papillomavirus (hpv)-unrelated disease, discriminates poorly when applied to hpv-related oropharyngeal squamous cell cancer (opscc), leading to calls for a new staging system. | 2017 | 27737449 |
| ecological association of human papillomavirus vaccination with cervical dysplasia prevalence in the united states, 2007-2014. | to examine prevalence of low- and high-grade cervical lesions over time in a large cohort of us female adolescents and women. | 2016 | 27736208 |
| human papillomaviruses genotyping in plantar warts. | plantar warts are caused by human papillomaviruses (hpvs) and have been associated with several hpv genotypes. however, there are few studies focused exclusively on plantar warts. in this work, we aim to identify the hpv genotypes of plantar warts and explore their relation to demographic and clinical characteristics of patients. a total of 72 patients diagnosed with plantar warts were recruited at the laser unit at podiatric hospital, university of barcelona, spain. inner hyperkeratosis laminar ... | 2017 | 27736001 |
| human papillomavirus and head and neck carcinomas: focus on evidence in the babel of published data. | human papillomavirus (hpv)-associated squamous cell carcinoma of the oropharynx is a well-defined entity mostly affecting young to middle-aged male non-smokers. it is generally associated with a favourable outcome, and for this reason a less intensive therapeutic approach has been proposed for this subset of patients. the incidence of hpv-associated oropharyngeal cancers is rapidly increasing in most western countries, but detailed epidemiological data are not available for the italian populatio ... | 2016 | 27734976 |
| diverse families' experiences with hpv vaccine information sources: a community-based participatory approach. | current sources of publicly available human papillomavirus (hpv) information may not adequately meet the needs of diverse families. this study sought to describe associations between sociodemographic and acculturation factors, and sources of hpv information among diverse parents and caregivers. community organizations purposively recruited participants from african american, african refugee, hispanic/latino, american indian, and native hawaiian and pacific islander communities for a 21-item surv ... | 2017 | 27734247 |
| phase ii trial of post-operative radiotherapy with concurrent cisplatin plus panitumumab in patients with high-risk, resected head and neck cancer. | treatment intensification for resected, high-risk, head and neck squamous cell carcinoma (hnscc) is an area of active investigation with novel adjuvant regimens under study. in this trial, the epidermal growth-factor receptor (egfr) pathway was targeted using the igg2 monoclonal antibody panitumumab in combination with cisplatin chemoradiotherapy (crt) in high-risk, resected hnscc. | 2016 | 27733374 |
| impact of hpv infection on oral squamous cell carcinoma. | head and neck squamous cell carcinomas (hnscc) are often divided by their aetiology. noxae associated collectives are compared with the human papilloma virus (hpv)-associated group, whereas different localisations of oral (oscc) and oropharyngeal (opscc) squamous cell carcinomas are mostly discussed as one single group. our aim was to show that classification by aetiology is not appropriate for oscc. | 2016 | 27732948 |
| gender and sexual health: same-sex relationships. | a transformation in legal and cultural attitudes toward same-sex relationships is under way nationwide. as same-sex marriage has become legal, the unique social and medicolegal issues faced by individuals in same-sex relationships are evolving rapidly. national organizations have published recommendations for making clinical environments more inclusive of lesbian, gay, bisexual, and queer (lgbq) individuals and their families. medical issues for patients in same-sex relationships include a highe ... | 2016 | 27731970 |
| knowledge of the hpv status biases cytotechnologists' interpretation of pap tests originally diagnosed as negative for intraepithelial lesion or malignancy. | because of cervical cancer screening recommendations and forthcoming first-line human papillomavirus (hpv) screening, many papanicolaou (pap) tests will be performed in patients with known concurrent hpv results. this study was designed to evaluate whether knowledge of the hpv status affects cytotechnologists' interpretation of pap tests. | 2017 | 27731938 |