Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| high-level cellular and humoral immune responses in guinea pigs immunized intradermally with a heat-inactivated varicella-zoster virus vaccine. | the threat of varicella and herpes zoster in immunocompromised individuals necessitates the development of a safe and effective varicella-zoster virus (vzv) vaccine. the immune responses of guinea pigs to the intradermal (i.d.) or subcutaneous (s.c.) administration of a heat-inactivated or live vzv vaccine were investigated. relative to nonimmunized animals, a single 399-pfu dose of vaccine induced nonsignificant increases in gamma interferon (ifn-γ), granzyme b, and perforin mrna expression in ... | 2015 | 25787138 |
| survey on public awareness, attitudes, and barriers for herpes zoster vaccination in south korea. | a cross-sectional study was performed to assess current public awareness of herpes zoster (hz) and its vaccine, determine the factors that influence people's intention regarding hz vaccination, and investigate the barriers for vaccination by changing decisions with sequential questions regarding knowledge, cost, and physician's recommendation in the department of infectious diseases, korea university guro hospital, in south korea, between august 23 and september 15 of 2013. among 603 subjects wh ... | 2015 | 25785481 |
| zoster vaccination increases the breadth of cd4+ t cells responsive to varicella zoster virus. | the live, attenuated varicella vaccine strain (voka) is the only licensed therapeutic vaccine. boost of varicella zoster virus (vzv)-specific cellular immunity is a likely mechanism of action. we examined memory cd4(+) t-cell responses to each vzv protein at baseline and after zoster vaccination. | 2015 | 25784732 |
| disseminated varicella-zoster virus in an immunocompetent adult. | varicella-zoster is the virus that causes varicella (chicken pox), herpes zoster (shingles), and rarely, severe disseminated disease including diffuse rash, encephalitis, hepatitis, and pneumonitis. disseminated disease is most often seen in immunocompromised patients. we describe a case of disseminated zoster in an immunocompentent patient who had previously been immune to vzv. this case is also unusual in that his clinical presentation was most consistent with varicella while his laboratory da ... | 2015 | 25780980 |
| varicella zoster virus encephalitis in a patient with disseminated herpes zoster: report and review of the literature. | herpes zoster infection occurs owing to reactivation of varicella zoster virus and classically manifests as a vesicular eruption involving a single dermatome. disseminated herpes zoster - defined as having greater than twenty vesicles outside the primary or adjacent dermatome - is uncommon and typically occurs in immunocompromised individuals. central nervous system complications during or following a zoster outbreak are exceedingly rare. encephalitis is reported to affect only 0.1-0.2% of patie ... | 2014 | 25780972 |
| herpes zoster involving penis and scrotum: an unusual occurrence. | herpes zoster is an infectious vesicular skin rash in a dermatomal distribution caused by varicella zoster virus. it occurs very uncommonly in sacral dermatomes. we describe a case with rash on penis and scrotum due to involvement of s2 dermatome in a young male. the disease followed an uneventful course and the patient recovered completely without any sequelae or complications. this case is being presented to highlight its unusual location and to discuss differentiation from another viral infec ... | 2015 | 25772966 |
| long-term survival in a patient with progressive multifocal leukoencephalopathy after therapy with rituximab, fludarabine and cyclophosphamide for chronic lymphocytic leukemia. | a 50-year-old male with chronic lymphocytic leukemia (cll) was treated with fludarabine, cyclophosphamide and rituximab, which produced a complete remission. eight months after the last dose of rituximab he had visual disturbance, diminished muscular strength in the right arm and vesicular-papular lesions in the left ophthalmic branch region of the v cranial nerve. these were initially interpreted as herpes virus encephalopathy (hve), but brain magnetic resonance imaging (mri) showed evidence of ... | 2015 | 25767742 |
| investigating the biology of alpha herpesviruses with ms-based proteomics. | viruses are intracellular parasites that can only replicate and spread in cells of susceptible hosts. alpha herpesviruses (α-hvs) contain double-stranded dna genomes of at least 120 kb, encoding for 70 or more genes. the viral genome is contained in an icosahedral capsid that is surrounded by a proteinaceous tegument layer and a lipid envelope. infection starts in epithelial cells and spreads to the peripheral nervous system. in the natural host, α-hvs establish a chronic latent infection that c ... | 2015 | 25764121 |
| the impact of demographic changes on the epidemiology of herpes zoster: spain as a case study. | varicella zoster virus (vzv) causes varicella upon first exposure and may reactivate later in life into herpes zoster (hz), with a risk that is thought to be reduced by re-exposures to vzv. given the decades-long time scales of reactivation and its dependence on the accumulation of re-exposure episodes, adopting a long-term perspective may be useful to correctly interpret current epidemiological trends of vzv. in this study, we investigate the possible impact of demographic changes on varicella ... | 2015 | 25761709 |
| genome-wide genetic investigation of serological measures of common infections. | populations and individuals differ in susceptibility to infections because of a number of factors, including host genetic variation. we previously demonstrated that differences in antibody titer, which reflect infection history, are significantly heritable. here we attempt to identify the genetic factors influencing variation in these serological phenotypes. blood samples from >1300 mexican americans were quantified for igg antibody level against 12 common infections, selected on the basis of th ... | 2015 | 25758998 |
| varicella zoster virus-associated anterior uveitis in a seronegative adult without a history of chickenpox. | the aim of this report was to present a case of varicella zoster virus (vzv)-associated anterior uveitis, which developed in an adult who was seronegative for anti-vzv antibodies. | 2015 | 25750518 |
| disseminated varicella-zoster virus involving the esophagus and stomach. | 2015 | 25746981 | |
| temporal trends in herpes zoster-related hospitalizations in madrid (spain), 2003-2013. | this study aimed to estimate herpes zoster (hz) related hospitalization rates in the autonomous community of madrid (spain), considering both total and complicated cases, and to analyze their temporal trends by sex and age. | 2015 | 25743583 |
| laboratory investigations of vaccinated patients with varicella. | accompanying varicella vaccination in children in germany recommended with one (2004) and two (2009) doses, sentinel surveillance of varicella with a sample (n∼900) of private physicians was established in 2005. physicians reported monthly aggregated data on all varicella cases and case-based on vaccinated patients, of whom skin lesion samples were laboratory investigated to identify varicella-zoster virus (vzv). we analyzed the impact of vaccination frequency on the number of cases and on labor ... | 2015 | 25738815 |
| varicella-zoster virus encephalitis mimicking toxoplasmosis relapse. | 2015 | 25738170 | |
| the characterization of varicella zoster virus-specific t cells in skin and blood during aging. | reactivation of the varicella zoster virus (vzv) increases during aging. although the effects of vzv reactivation are observed in the skin (shingles), the number and functional capacity of cutaneous vzv-specific t cells have not been investigated. the numbers of circulating ifn-γ-secreting vzv-specific cd4(+) t cells are significantly decreased in old subjects. however, other measures of vzv-specific cd4(+) t cells, including proliferative capacity to vzv antigen stimulation and identification o ... | 2015 | 25734814 |
| varicella zoster virus pneumonitis and brainstem encephalitis without skin rash in an immunocompetent adult. | varicella zoster virus (vzv) pneumonitis and brainstem encephalitis developed in an immunocompetent adult without rash. chest computed tomography exhibited nodularity; lung biopsy revealed multinucleated giant cells, cowdry a inclusions, vzv antigen, and dna. varicella zoster virus central nervous system disease was verified by cerebrospinal fluid (csf) anti-vzv igg antibody with reduced serum/csf ratios. | 2014 | 25734134 |
| high-resolution mri vessel wall imaging in varicella zoster virus vasculopathy. | contrast-enhanced vessel wall imaging high-resolution mri (hrmr) has revealed vessel wall thickening and enhancement in multiple intracranial vasculopathies, including varicella zoster virus (vzv) vasculopathy. we retrospectively reviewed a database of patients with virologically-verified vzv vasculopathy, who underwent initial and follow-up hrmr between april 2011 and may 2014. six patients were identified. baseline demographic and clinical characteristics were collected, including stroke risk ... | 2015 | 25732801 |
| curious discoveries in antiviral drug development: the role of serendipity. | antiviral drug development has often followed a curious meandrous route, guided by serendipity rather than rationality. this will be illustrated by ten examples. the polyanionic compounds (i) polyethylene alanine (pea) and (ii) suramin were designed as an antiviral agent (pea) or known as an antitrypanosomal agent (suramin), before they emerged as, respectively, a depilatory agent, or reverse transcriptase inhibitor. the 2',3'-dideoxynucleosides (ddns analogues) (iii) have been (and are still) u ... | 2015 | 25726922 |
| varicella-zoster virus claims yet another painful scalp--giant cell arteritis. | 2015 | 25724229 | |
| trends in varicella mortality in the united states: data from vital statistics and the national surveillance system. | this manuscript describes trends in us varicella mortality using national vital statistics system data for 2008-2011, the first years of the routine 2-dose varicella vaccination program, and characteristics of varicella deaths reported to cdc during 1996-2013. we obtained data on deaths with varicella as underlying or contributing cause from the 2008-2011 mortality multiple cause-of death records and calculated rates to compare with the prevaccine and mature 1-dose varicella vaccination program ... | 2015 | 25714052 |
| the relationship between herpes zoster and stroke. | varicella zoster virus (vzv) infects >95 % of the world population. typically, varicella (chickenpox) results from primary infection. the virus then becomes latent in ganglionic neurons along the entire neuraxis. in immunocompromised individuals, vzv reactivates and causes herpes zoster (shingles), pain, and rash in 1-2 dermatomes. multiple case reports showed a link between stroke and zoster, and recent studies have emerged which reveal that vzv infection of the cerebral arteries directly cause ... | 2015 | 25712420 |
| drug resistance of clinical varicella-zoster virus strains confirmed by recombinant thymidine kinase expression and by targeted resistance mutagenesis of a cloned wild-type isolate. | in this study, approaches were developed to examine the phenotypes of nonviable clinical varicella-zoster virus (vzv) strains with amino acid substitutions in the thymidine kinase (tk) (open reading frame 36 [orf36]) and/or dna polymerase (pol) (orf28) suspected to cause resistance to antivirals. initially, recombinant tk proteins containing amino acid substitutions described as known or suspected causes of antiviral resistance were analyzed by measuring the tk activity by applying a modified co ... | 2015 | 25712361 |
| management of ramsay hunt syndrome in an acute palliative care setting. | the ramsay hunt syndrome is characterized by combination of herpes infection and lower motor neuron type of facial nerve palsy. the disease is caused by a reactivation of varicella zoster virus and can be unrepresentative since the herpetic lesions may not be always be present (zoster sine herpete) and might mimic other severe neurological illnesses. | 2017 | 25709192 |
| [parsonage-turner syndrome following varicella-zoster virus infection]. | 2015 | 25704804 | |
| common childhood viral infections. | infections caused by viruses are universal during childhood and adolescence. clinicians will regularly care for children and adolescents who present with infections caused by a wide number of viral pathogens. these infections have varied presentations. many infections may have clinical presentations that are specific to the infecting virus but present differently, based on the age and immunocompetence of the patient. some children are directly impacted early in their lives when maternal disease ... | 2015 | 25703483 |
| [guidelines for antifungal prophylaxis, diagnosis and therapy in pediatric hematology and oncology - a review of literature and expert recommendations]. | problems with importing non-registered medicines for treating rare life-threatening infectious diseases led to establishment of the emergency anti-infective drug reserve (eaidr) for the czech republic. | 2014 | 25702289 |
| prevalence and distribution of vzv in temporal arteries of patients with giant cell arteritis. | varicella-zoster virus (vzv) infection may trigger the inflammatory cascade that characterizes giant cell arteritis (gca). | 2015 | 25695965 |
| safety and immunogenicity of single dose live attenuated varicella vaccine (vr 795 oka strain) in healthy indian children: a randomized controlled study. | varicella, an acute viral systemic infection that may cause lifelong latent infection with the potential for causing clinical reactivation, may be prevented by immunization. the present study was an open label, randomized, controlled, phase iii, multicentre trial, conducted to evaluate and compare the safety, tolerability and immunogenicity of a freeze dried live attenuated oka strain varicella vaccine (vr 795 oka strain) with varilrix (oka-rit strain) in children. a total of 268 healthy indian ... | 2015 | 25692656 |
| varicella-zoster meningitis with a late-onset of skin eruption. | viral meningitis caused by varicella-zoster virus (vzv) is an uncommon neurological complication of herpes zoster. it may occur before or after the onset of the vesicular rash along the dermatomal distribution, which is the classic presentation of herpes zoster. we describe a case of a 51-year-old immunocompetent caucasian man who presented with neck and severe right-sided facial pain. eight days later, he had photophobia and papular rash on his forehead. cerebrospinal fluid (csf) examination co ... | 2015 | 25691578 |
| rare varicella zoster virus infection in an alt free flap. | 2016 | 25690120 | |
| a manual and an automatic ters based virus discrimination. | rapid techniques for virus identification are more relevant today than ever. conventional virus detection and identification strategies generally rest upon various microbiological methods and genomic approaches, which are not suited for the analysis of single virus particles. in contrast, the highly sensitive spectroscopic technique tip-enhanced raman spectroscopy (ters) allows the characterisation of biological nano-structures like virions on a single-particle level. in this study, the feasibil ... | 2015 | 25686406 |
| the immunogenicity and safety of zoster vaccine in taiwanese adults. | the efficacy and safety of zostavax in subjects 60 years of age and older was established in the shingles prevention study (sps) and in subjects 50 to 59 years of age in the zostavax efficacy and safety trial (zest). we evaluated the safety and immunogenicity of zostavax in a total of 150 taiwanese subjects ≥50 years of age, who received a single dose of zostavax. gpelisa was used to determine geometric mean titers (gmt) of the varicella-zoster virus (vzv) antibody. the geometric mean fold rise ... | 2015 | 25681662 |
| the anti-obesity drug orlistat reveals anti-viral activity. | the administration of drugs to inhibit metabolic pathways not only reduces the risk of obesity-induced diseases in humans but may also hamper the replication of different viral pathogens. in order to investigate the value of the us food and drug administration-approved anti-obesity drug orlistat in view of its anti-viral activity against different human-pathogenic viruses, several anti-viral studies, electron microscopy analyses as well as fatty acid uptake experiments were performed. the result ... | 2015 | 25680890 |
| perinatal cytomegalovirus and varicella zoster virus infections: epidemiology, prevention, and treatment. | mother-to-child transmission of cytomegalovirus (cmv) and varicella zoster virus (vzv) can lead to severe birth defects and neurologic impairment of infants. congenital cmv complicates up to 1% of all pregnancies globally. although antiviral treatment of infants congenitally infected with cmv can ameliorate the cmv-associated hearing loss and developmental delay, interventions to prevent congenital cmv infection and the associated neurologic impairments are still being evaluated. congenital vzv ... | 2015 | 25677997 |
| absence of varicella zoster virus reactivation after infliximab administration for plaque psoriasis. | herpes zoster (hz) in patients receiving tumor necrosis factor (tnf) antagonists may be more severe and the incidence seems increased. the influence of tnf antagonists on varicella zoster virus (vzv) reactivation is unknown. | 2015 | 25676341 |
| epidemic varicella zoster virus reactivation in renal transplant recipients: a case report. | immunosuppression after transplantation renders the transplant recipient susceptible to a broad array of viral pathogens. of 31 patients transplanted during 2012 in our center, 6 (19.3%) experienced varicella zoster virus (vzv) reactivation. the median time from transplantation to reactivation was 6.2 months. immunosuppression consisted of antithymocyte globulin in 5 patients and basiliximab in 1, followed by tacrolimus, mycophenolic acid, and prednisolone. two patients had t-cell-mediated rejec ... | 2016 | 25645794 |
| use of clinical and neuroimaging characteristics to distinguish temporal lobe herpes simplex encephalitis from its mimics. | we describe the spectrum of etiologies associated with temporal lobe (tl) encephalitis and identify clinical and radiologic features that distinguish herpes simplex encephalitis (hse) from its mimics. | 2015 | 25637586 |
| arsenic exposure and prevalence of the varicella zoster virus in the united states: nhanes (2003-2004 and 2009-2010). | arsenic is an immunotoxicant. clinical reports observe the reactivation of varicella zoster virus (vzv) in people who have recovered from arsenic poisoning and in patients with acute promyelocytic leukemia that have been treated with arsenic trioxide. | 2015 | 25636148 |
| identification of three redundant segments responsible for herpes simplex virus 1 icp0 to fuse with nd10 nuclear bodies. | infected cell protein 0 (icp0) of herpes simplex virus 1 (hsv-1) is a key regulator in both lytic and latent infections. in lytic infection, an important early event is the colocalization of icp0 to nuclear domain 10 (nd10), the discrete nuclear bodies that impose restrictions on viral expression. icp0 contains an e3 ubiquitin ligase that degrades promyelocytic leukemia protein (pml) and sp100, two major components of nd10, and disperses nd10 to alleviate repression. we previously reported that ... | 2015 | 25631093 |
| sensorineural hearing loss in hemorrhagic dengue? | dengue is an acute febrile infectious disease, with high fever followed by symptoms flu-like. dengue hemorrhagic fever (dhf) is a vascular leak syndrome and could present spontaneous bleeding and worsening of symptoms after some days. dengue could have some ent manifestations, however hearing loss is not one of them. sudden hearing loss is considered as sensorineural or perceptual hearing loss with a sudden onset in a person without other prior otological history. the relation between infectious ... | 2014 | 25625489 |
| varicella zoster virus meningitis in a young immunocompetent adult without rash: a misleading clinical presentation. | meningitis caused by varicella zoster virus (vzv) is rare in healthy population. predominantly immunocompromised patients are affected by reactivation of this virus with primary clinical features of rash and neurological symptoms. here we report a young otherwise healthy man diagnosed with a vzv meningitis without rash. he complained of acute headache, nausea, and vomiting. the clinical examination did not show any neurological deficits or rash. cerebrospinal fluid (csf) analysis revealed a high ... | 2014 | 25614843 |
| [varicella-zoster virus infection in a child complicated with bacterial pneumonia]. | this case report describes how a three-year-old girl referred to our paediatric ward, infected with varicella-zoster virus and a bacterial pneumonia causing atelectasis. the girl did not respond to initial treatment with intravenous antibiotics. only after a lung drain was inserted she gradually recovered. we briefly describe the incidence of bacterial pneumonia as a complication to varicella-zoster virus and raise the question whether to vaccinate against varicella-zoster virus. | 2015 | 25612944 |
| viruses, apoptosis, and neuroinflammation--a double-edged sword. | apoptosis, or programmed cell death, is a fundamental and widespread cell biological process that is distinct from cell necrosis and can be induced by a wide variety of stimuli including viral infections. apoptosis may occur via either the intrinsic or extrinsic pathways and confers several advantages to the virally infected host including the prevention of further viral propagation and the potential inhibition and resolution of inflammatory processes. several viruses have been shown to have the ... | 2015 | 25604493 |
| the association of varicella zoster virus reactivation with bell's palsy in children. | bell's palsy is considered the most common cause of facial nerve paralysis in children. although different theories have been postulated for its diagnosis, reactivation of the varicella zoster virus (vzv) has been implicated as one of the causes of bell's palsy. the aim of the study was to evaluate the association of varicella-zoster virus infection with bell's palsy and its outcome in children. | 2015 | 25599860 |
| varicella zoster virus reactivation after autologous sct is a frequent event and associated with favorable outcome in myeloma patients. | the occurrence of varicella zoster virus (vzv) reactivation is increased after allogeneic transplantation, whereas limited data are available for herpes zoster (hz) after autologous sct (asct). we determined the incidence and the prognostic significance of hz and its correlation with vzv serology in 191 consecutive myeloma patients undergoing high-dose melphalan chemotherapy with asct. we found that vzv reactivation occurred in 57 (30%) patients, in 8.5% during induction and in 21.5% after asct ... | 2015 | 25599166 |
| evaluation of a multiplex bead immunoassay for determination of immune status to varicella-zoster virus in medical center students and employees. | this study evaluated an enzyme immunoassay, a multiplex bead immunoassay (mbia), and the anticomplement immunofluorescence (acif) test for detecting varicella-zoster virus igg antibodies in sera from medical center students and employees. the agreement between methods was ≥95%. the mbia was less sensitive than was the acif test, with a negative predictive value of 66.7%. | 2015 | 25589555 |
| viral infections in acute graft-versus-host disease: a review of diagnostic and therapeutic approaches. | while immunosuppressive therapy for acute graft-versus-host disease (agvhd) advances, viral reactivation has been found to be an increasingly common complication in these patients. dermatologists may often be consulted on inpatient services for evaluation. | 2015 | 25582535 |
| herpesviruses and breast milk. | breast milk has always been the best source of nourishment for newborns. however, breast milk can carry a risk of infection, as it can be contaminated with bacterial or viral pathogens. this paper reviews the risk of acquisition of varicella-zoster virus (vzv) and cytomegalovirus (cmv), herpesviruses frequently detected in breastfeeding mothers, via breast milk, focusing on the clinical consequences of this transmission and the possible strategies for preventing it. maternal vzv infections are c ... | 2014 | 25573640 |
| a 'cocoon immunization strategy' among patients with inflammatory bowel disease. | a 'cocoon strategy' is defined as the strategy of protecting vulnerable patients from infectious diseases by vaccinating those in close contact with them. in our study, we evaluate the vaccination status among children living with patients with inflammatory bowel disease (ibd) to determine the realization of the cocoon strategy and to identify characteristics associated with pediatric vaccine refusal. | 2015 | 25569568 |
| criteria for reducing unnecessary testing for herpes simplex virus, varicella-zoster virus, cytomegalovirus, and enterovirus in cerebrospinal fluid samples from adults. | excessive utilization of laboratory diagnostic testing leads to increased health care costs. we evaluated criteria to reduce unnecessary nucleic acid amplification testing (naat) for viral pathogens in cerebrospinal fluid (csf) samples from adults. this is a single-center split retrospective observational study with a screening cohort from 2008 to 2012 and a validation cohort from 2013. adults with available results for herpes simplex virus 1/2 (hsv-1/2), varicella-zoster virus (vzv), cytomegalo ... | 2015 | 25568435 |
| rates of vaccine evolution show strong effects of latency: implications for varicella zoster virus epidemiology. | varicella-zoster virus (vzv) causes chickenpox and shingles, and is found in human populations worldwide. the lack of temporal signal in the diversity of vzv makes substitution rate estimates unreliable, which is a barrier to understanding the context of its global spread. here, we estimate rates of evolution by studying live attenuated vaccines, which evolved in 22 vaccinated patients for known periods of time, sometimes, but not always undergoing latency. we show that the attenuated virus evol ... | 2015 | 25568346 |
| one-year follow-up of zoster-associated pain in 764 immunocompetent patients with acute herpes zoster treated with famciclovir (familiar study). | herpes zoster (hz), a reactivation of varicella zoster virus manifested by skin blisters and neuralgia, can lead to postherpetic neuralgia in 10-20% of affected subjects. | 2014 | 25564680 |
| lack of association between human herpesvirus and vestibular schwannoma: analysis of 121 cases. | to assess for the presence of human herpesvirus (hhv) using immunohistochemical and polymerase chain reaction (pcr) assay in surgically excised vestibular schwannoma (vs) samples. | 2015 | 25560404 |
| satellite lesions accompanying herpes zoster: a new prognostic sign for high-risk zoster. | the incidence, clinical relevance and pathogenesis of single, isolated, varicella-like skin lesions occurring far beyond the primary herpes zoster (hz)-affected dermatome remain unclear. | 2015 | 25556958 |
| comparison of intramuscular and subcutaneous administration of a herpes zoster live-attenuated vaccine in adults aged ≥50 years: a randomised non-inferiority clinical trial. | zostavax(®) is a live, attenuated varicella zoster virus (vzv) vaccine developed specifically for the prevention of hz and phn in individuals aged ≥50 years. during the clinical development of zostavax, which was mainly in the us, the vaccine was administrated by the subcutaneous (sc) route. in europe, many healthcare professionals prefer administering vaccines by the intramuscular (im) route. this was an open-label, randomised trial conducted in 354 subjects aged ≥50 years. the primary objectiv ... | 2015 | 25555381 |
| acute pancreatitis associated with herpes zoster: case report and literature review. | varicella-zoster virus (vzv) is a type of herpes virus known to cause varicella, mainly in young children, and herpes zoster in adults. although generally non-lethal, vzv infection can be associated with serious complications, particularly in adults. acute pancreatitis caused by vzv infection is a rare event, with reports primarily concerning immunocompromised individuals. here we report a 44-year-old immunocompetent female who developed acute pancreatitis associated with vzv infection. the pati ... | 2014 | 25548507 |
| ocular herpes: the pathophysiology, management and treatment of herpetic eye diseases. | herpesviruses are a prominent cause of human viral disease, second only to the cold and influenza viruses. most herpesvirus infections are mild or asymptomatic. however, when the virus invades the eye, a number of pathologies can develop and its associated sequelae have become a considerable source of ocular morbidity. the most common culprits of herpetic eye disease are the herpes simplex virus (hsv), varicella zoster virus (vzv), and cytomegalovirus (cmv). while primary infection can produce o ... | 2014 | 25547680 |
| autophagic flux without a block differentiates varicella-zoster virus infection from herpes simplex virus infection. | autophagy is a process by which misfolded and damaged proteins are sequestered into autophagosomes, before degradation in and recycling from lysosomes. we have extensively studied the role of autophagy in varicella-zoster virus (vzv) infection, and have observed that vesicular cells are filled with >100 autophagosomes that are easily detectable after immunolabeling for the lc3 protein. to confirm our hypothesis that increased autophagosome formation was not secondary to a block, we examined all ... | 2015 | 25535384 |
| seasonal variation and trend of chicken pox in the southern region of saudi arabia (2007-2012). | chicken pox is a contagious disease caused by varicella zoster virus. children are most susceptible to infection. in 1998, the who recommended that routine childhood varicella vaccination be considered in countries where the disease is a relatively important public health concern. there are few data on the trends of chicken pox. we aimed to evaluate the trend of chicken pox in saudi arabia (ksa) during the period 2007-2012. | 2014 | 25534179 |
| a prospective study of the clinical characteristics of patients with herpes simplex and varicella zoster keratitis, presenting to a new zealand emergency eye clinic. | to identify the demographic and clinical associations of patients presenting with herpetic keratitis in new zealand compared with presentations of presumed microbial keratitis. | 2015 | 25532996 |
| varicella zoster virus encephalomyelitis as a late complication following haematopoietic stem cell transplantation. | varicella zoster virus (vzv) causes the primary infection manifesting as varicella or chickenpox, with possibility of reactivation later in life. a 71-year-old man presented with headache and lower extremity weakness. there was no evidence of skin lesions to suggest a recent zoster infection. the patient had a history of multiple myeloma diagnosed 2 years earlier, treated with chemotherapy and autologous stem cell transplant. antimicrobial prophylaxis was discontinued 12 months after the transpl ... | 2014 | 25527690 |
| [activity and cost related to hospital management of herpes zoster in france: focus on ophthalmic herpes zoster]. | herpes zoster secondary to reactivation and replication of the varicella zoster virus (vzv) caused a painful disease which impact the quality of life. among the complications, herpes zoster ophtalmicus was responsible to post-herpetic neuralgia and lesions of the ocular globus. the aim of this study is to evaluated the burden and cost of herpes zoster in secondary care in france with focus on herpes zoster ophtalmicus (hzo). | 2014 | 25515904 |
| evaluation of 2 multiplex real-time pcr assays for the detection of hsv-1/2 and varicella zoster virus directly from clinical samples. | we compared the performance of 2 multiplex assays (focus simplexa and quidel lyra) to individual real-time pcr for the detection of herpes simplex virus-1 (hsv-1), hsv-2, and varicella zoster virus (vzv) from clinical specimens. results were compared to a consensus standard, defined as the result obtained by at least 2 of the 3 molecular methods. the sensitivity of the quidel assay ranged from 92.0% for hsv-1 to 97.7% for hsv-2, while the specificity for all targets was 100%. the focus assay dem ... | 2015 | 25511233 |
| fatal visceral varicella-zoster developing early after autologous hematopoietic stem cell transplantation for refractory diffuse large b-cell lymphoma. | a middle-aged woman who had undergone autologous hematopoietic stem cell transplantation (hsct) 1 month previously suffered severe epigastralgia and relapse of lymphoma. the epigastralgia was not relieved by chemotherapy. thereafter, her pancreatic and hepatic enzyme levels were markedly elevated and disseminated varicella emerged. despite acyclovir administration, her general condition deteriorated rapidly and she died. serum varicella zoster virus (vzv) dna level was shown to be elevated and a ... | 2014 | 25501115 |
| [effect of acyclovir and steroid in a young immunocompetent male with herpes zoster myelitis]. | herpes zoster myelitis is a rare condition, usually seen in aged and immunocompromised patients. due to atypical presen-tations it can be hard to diagnose. intraspinal lesions on magnetic resonance imaging (mri) support the diagnosis. we present a 39-year-old otherwise healthy male with symptoms of viral meningitis and rapidly progressing symptoms of myelitis. lumbar puncture showed increased levels of monocytes and varicella zoster virus dna. despite a negative mri, based on a few previous case ... | 2014 | 25497608 |
| [meningoencephalitis caused by west nile virus in a renal transplant recipient]. | west nile virus (wnv) infection which is asymptomatic or mild in normal population, it may cause serious clinical conditions leading to death in eldery and immunosupressed patients. the virus is mainly transmitted by mosquito bites, however transfusion, transplantation, transplasental and nosocomial ways have also been reported to be responsible for viral transmission. it is known that wnv may cause life-threatining conditions such as central nervous system (cns) infections especially in bone ma ... | 2014 | 25492663 |
| development and validation of new diagnostic criteria for acute retinal necrosis. | the purposes of this study are to develop and validate new diagnostic criteria for acute retinal necrosis (arn) based on the ocular findings, clinical course, and virologic testing of intraocular fluids. | 2015 | 25492579 |
| serum vitamin d levels are positively associated with varicella zoster immunity in chronic dialysis patients. | uremia results in a relatively immunocompromised status, and patients under chronic dialysis have an elevated risk of developing herpes zoster (hz). we sought to investigate the relationship between vitamin d status and immunity to varicella-zoster virus (vzv). a multicenter prevalent hemodialysis cohort was assembled between 2012 and 2013. we assayed the biochemical parameters, 25-hydroxy- (25-oh-d) and 1,25-dihydroxyvitamin d, vitamin d-binding protein levels in the sera. vzv immunity was quan ... | 2014 | 25487609 |
| hospitalization with varicella and shingles before and after introduction of childhood varicella vaccination in germany. | in germany, one dose of varicella vaccination has been recommended for children aged <24 months since 2004, and 2 doses have been recommended since 2009. vaccination coverage (vc) is above 80% for one dose and 60% for 2 doses. in this study, data on varicella- and shingles-associated hospitalizations before and after vaccine introduction were assessed. based on icd-coded data of the main diagnosis of hospitalized cases from 1995-2012 in germany, annual age-adjusted and age-specific hospitalizati ... | 2014 | 25483695 |
| the burden of disease of herpes zoster in tuscany. | herpes zoster (hz) is a disease caused by the reactivation of the latent α-herpes virus varicella zoster virus (vzv), for which, in italy, a specific surveillance system does not exist, but around 200 000 cases are estimated each year. in older patients, who are at increased risk of developing hz, symptoms are more severe and the chances to develop postherpetic neuralgia (phn), the most severe complication, are substantially higher. a vaccine against hz with demonstrated efficacy and an acceptab ... | 2015 | 25483534 |
| herpes zoster and postherpetic neuralgia in catalonia (spain). | the objective of the study was to analyze the descriptive epidemiology and costs of herpes zoster (hz) and postherpetic neuralgia (phn) in people aged ≥50 years in catalonia (spain). the incidence of hz in catalonia was estimated by extrapolating the incidence data from navarre (spain) to the population of catalonia. the incidence of phn was estimated according to the proportion of cases of hz in the case series of the hospital del sagrado corazón de barcelona that evolved to phn. drug costs wer ... | 2015 | 25483532 |
| attitude toward immunization and risk perception of measles, rubella, mumps, varicella, and pertussis in health care workers working in 6 hospitals of florence, italy 2011. | health care workers (hcws) are at risk of infection and transmission of vaccine-preventable infectious diseases. in recent years cases of measles or varicella in health care workers were observed with increasing frequency. the aim of our study was to investigate attitude toward immunization and risk perception of measles, rubella, mumps, varicella, and pertussis in hcws working in 6 hospitals of florence (italy). | 2014 | 25483489 |
| characteristics of uveitic glaucoma and evaluation of its surgical treatment. | to investigate the characteristics of uveitic glaucoma (ug) and evaluate surgical treatments. | 2014 | 25473265 |
| deletion of the orf9p acidic cluster impairs the nuclear egress of varicella-zoster virus capsids. | the protein encoded by orf9 is essential for varicella-zoster virus (vzv) replication. previous studies documented its presence in the trans-golgi network and its involvement in secondary envelopment. in this work, we deleted the orf9p acidic cluster, destroying its interaction with orf47p, and this resulted in a nuclear accumulation of both proteins. this phenotype results in an accumulation of primary enveloped capsids in the perinuclear space, reflecting a capsid de-envelopment defect. | 2015 | 25473054 |
| vzv encephalitis following successful treatment of cmv infection in a patient with kidney transplant. | a 73-year-old woman with a history of deceased donor kidney transplantation and a recent cytomegalovirus (cmv) infection, presented to the emergency department with an altered mental status. she was found to have varicella zoster virus vzv encephalitis based on cerebrospinal fluid analysis and was treated successfully with intravenous valaciclovir with an improvement in her mental status. a review of the literature shows very few case reports on patients with kidney transplantation developing vz ... | 2014 | 25465457 |
| herpes zoster in children vaccinated against varicella-zoster virus: experience in our hospital. | 2015 | 25456110 | |
| varicella-zoster virus vaccination under the exogenous boosting hypothesis: two ethical perspectives. | the varicella-zoster virus (vzv) causes two diseases: varicella ('chickenpox') and herpes zoster ('shingles'). vzv vaccination of children reduces exposure to chickenpox in the population and it has been hypothesized that this could increase the prevalence of shingles. this 'exogenous boosting' effect of vzv raises an important equity concern: introducing a vaccination program could advance the health of one population group (children) at the expense of another (adults and elderly). we discuss t ... | 2014 | 25454883 |
| varicella-zoster virus and virus dna in the blood and oropharynx of people with latent or active varicella-zoster virus infections. | varicella-zoster virus (vzv) can be detected in the blood from approximately 5 days before to 4 days after varicella. vzv dna, primarily in t-lymphocytes, is detected as early as 8-10 days prior to rash and can persist for a week. the duration and magnitude of vzv dnaemia correlates with immune status and the efficacy of antiviral therapy. vzv dna is also readily detected in the oropharynx just prior to rash and for 1-2 weeks thereafter. detection of vzv dna in blood and saliva has been useful f ... | 2014 | 25453570 |
| disseminated, persistent, and fatal infection due to the vaccine strain of varicella-zoster virus in an adult following stem cell transplantation. | live attenuated varicella vaccine is recommended for healthy individuals who are susceptible to varicella. although the vaccine is safe, effective, and used worldwide, serious adverse events have been reported, mainly in immunocompromised patients who subsequently recovered. here, we describe the fatality of an immunocompromised patient who received the varicella vaccine. his medical history provides a cautionary lens through which to view the decision of when vaccination is appropriate. a middl ... | 2015 | 25452596 |
| varicella vaccination coverage inverse correlation with varicella hospitalizations in spain. | varicella vaccines available in spain were marketed in 1998 and 2003 for non-routine use. since 2006 some regions included universal varicella vaccination in their regional routine vaccination programs at 15-18 months of age. regions without universal vaccination in toddlers, but instead with the strategy of vaccinating susceptible adolescents, reached different varicella vaccination coverage through private market. this study shows the correlation between severe varicella zoster virus infection ... | 2014 | 25444825 |
| use of a current varicella vaccine as a live polyvalent vaccine vector. | varicella-zoster virus (vzv) is the causative agent of varicella and zoster. the varicella vaccine was developed to control vzv infection in children. the currently available oka vaccine strain is the only live varicella vaccine approved by the world health organization. we previously cloned the complete genome of the oka vaccine strain into a bacterial artificial chromosome vector and then successfully reconstituted the virus. we then used this system to generate a recombinant oka vaccine virus ... | 2016 | 25444800 |
| varicella zoster virus-associated generalized pustular psoriasis in a baby with heterozygous il36rn mutation. | 2014 | 25438000 | |
| animal models of varicella zoster virus infection. | primary infection with varicella zoster virus (vzv) results in varicella (chickenpox) followed by the establishment of latency in sensory ganglia. declining t cell immunity due to aging or immune suppressive treatments can lead to vzv reactivation and the development of herpes zoster (hz, shingles). hz is often associated with significant morbidity and occasionally mortality in elderly and immune compromised patients. there are currently two fda-approved vaccines for the prevention of vzv: variv ... | 2013 | 25437040 |
| cost-effectiveness of vaccination against herpes zoster. | herpes zoster (hz) is a common disease among elderly, which may develop into a severe pain syndrome labeled postherpetic neuralgia (phn). a live-attenuated varicella zoster virus vaccine has been shown to be effective in reducing the incidence and burden of illness of hz and phn, providing the opportunity to prevent significant health-related and financial consequences of hz. in this review, we summarize the available literature on cost-effectiveness of hz vaccination and discuss critical parame ... | 2014 | 25424815 |
| fingolimod and risk of varicella-zoster virus infection: back to the future with an old infection and a new drug. | 2015 | 25420159 | |
| varicella-zoster virus infections in patients treated with fingolimod: risk assessment and consensus recommendations for management. | varicella-zoster virus (vzv) infections increasingly are reported in patients with multiple sclerosis (ms) and constitute an area of significant concern, especially with the advent of more disease-modifying treatments in ms that affect t-cell-mediated immunity. | 2015 | 25419615 |
| relapsing pityriasis rosea. | to assess the prevalence of relapses of pityriasis rosea (pr), a retrospective cohort study investigated all pr cases diagnosed in genoa between 2000 and 2013 and followed them up to today. of 570 cases, 21 (3.7%) relapsed. most of them had a single episode, but 4 had two episodes and 2 had three episodes. the herald patch was always absent, size and number of the lesions were reduced, and duration was shorter than that of the primary episodes. constitutional symptoms were present, though less s ... | 2014 | 25412725 |
| [infections caused by human alpha herpes viruses]. | varicella-zoster virus (vzv), herpes simplex virus one (hsv-1) and herpes simplex virus two (hsv-2) represent three out of the eight known human herpesviruses and belong to the subfamily of α-herpesviruses. these viruses are present worldwide and humans are their sole host and reservoir. after the primary infection, these viruses persist in the body throughout life. the period of latency may be interrupted by reactivation of infection due to various factors. each virus can induce a wide spectrum ... | 2014 | 25412485 |
| abortive intrabronchial infection of rhesus macaques with varicella-zoster virus provides partial protection against simian varicella virus challenge. | varicella-zoster virus (vzv) is a human neurotropic alphaherpesvirus and the etiological agent of varicella (chickenpox) and herpes zoster (hz, shingles). previously, inoculation of monkeys via the subcutaneous, intratracheal, intravenous, or oral-nasal-conjunctival routes did not recapitulate all the hallmarks of vzv infection, including varicella, immunity, latency, and reactivation. intrabronchial inoculation of rhesus macaques (rms) with simian varicella virus (svv), a homolog of vzv, recapi ... | 2015 | 25410871 |
| oligoclonal restriction of antiviral immunoreaction in oligoclonal band-negative ms patients. | presence of oligoclonal bands (ocb) in cerebrospinal fluid (csf) is a diagnostic hallmark of multiple sclerosis (ms). however, up to 10% of patients were ocb negative in routine laboratory tests. the aim of this study was to determine whether there is at least an oligoclonal restriction of intrathecal antibody synthesis against measles, rubella and/or varicella zoster virus (mrz-specific ocb) in csf from oligoclonal bands-negative patients with ms. | 2015 | 25402869 |
| vaccines for the elderly. | the aging of the human population is posing serious challenges to research and to public health authorities in order to prevent diseases that more frequently affect the elderly, a portion of the population that will increase more and more in the coming years. while some vaccines exist and are used in the elderly to effectively fight against some infections (e.g. influenza, pneumococci, varicella-zoster virus, diphtheria, and tetanus), still a lot of work remains to be done to better adapt these ... | 2015 | 25402229 |
| clinical characteristics and cost of chickenpox hospitalization in thai children. | although primary varicella-zoster-virus (vzv) infection generally causes uncomplicated illness confined to skin and mucous membrane among healthy children, it infrequently causes life-threatening infection especially among immuno-suppressed hosts or young infants. limited information is available regarding the clinical features, outcomes, and the financial burden incurred by severe primary varicella infection in thai children who required hospitalization. | 2014 | 25391184 |
| necrotizing herpetic retinopathy after intravitreal triamcinolone acetonide injection. | to report a new complication of intravitreal triamcinolone acetonide (ta) injection. | 2007 | 25390980 |
| bilateral viral retinitis in a patient with immune deficiency because of purine nucleoside phosphorylase deficiency. | progressive retinal outer necrosis is a devastating viral necrotizing retinitis, which affects predominantly immunocompromised patients. we report a case in which the ocular findings led to a search for an underlying immune deficiency, established as congenital purine nucleoside phosphorylase deficiency. | 2012 | 25390949 |
| acute retinal necrosis after corticosteroid pulse therapy for unilateral vogt-koyanagi-harada disease. | to report on a patient with unilateral vogt-koyanagi-harada (vkh) disease who developed varicella zoster-associated acute retinal necrosis after corticosteroid pulse therapy for the vkh disease. | 2010 | 25390121 |
| epstein-barr infection of the retina: case report and review of the literature. | the purpose of this study is to describe a presumed case of epstein-barr virus (ebv) infection of the retina in a 65-year-old female with sudden bilateral vision loss. | 2011 | 25389670 |
| safety and immunogenicity of an adjuvanted herpes zoster subunit candidate vaccine in hiv-infected adults: a phase 1/2a randomized, placebo-controlled study. | human immunodeficiency virus (hiv)-infected individuals are at increased risk of herpes zoster (hz), even in the antiretroviral therapy (art) era. because concerns exist about the use of live-attenuated vaccines in immunocompromised individuals, a subunit vaccine may be an appropriate alternative. | 2015 | 25371534 |
| [the prevalence of active infection with viruses from the family herpesviridae among members of families with children]. | cytomegalovirus infection (cmv) is one of the most common viral infections during pregnancy and one of the most common causes of birth defects in newborns. cmv infection occurs mostly through close contact with small children who can secrete the virus in saliva and urine. children, especially in preschool and early school can also be a source of infection with other herpesviruses. the aim of the study was to determine the prevalence of active infections caused by viruses from the family herpesvi ... | 2014 | 25369658 |
| etiologic agents of central nervous system infections among febrile hospitalized patients in the country of georgia. | there is a large spectrum of viral, bacterial, fungal, and prion pathogens that cause central nervous system (cns) infections. as such, identification of the etiological agent requires multiple laboratory tests and accurate diagnosis requires clinical and epidemiological information. this hospital-based study aimed to determine the main causes of acute meningitis and encephalitis and enhance laboratory capacity for cns infection diagnosis. | 2014 | 25369023 |