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refinement of the solution structure of the dna hexamer 5'd(gcatgc)2: combined use of nuclear magnetic resonance and restrained molecular dynamics.the solution structure of the self-complementary dna hexamer 5'd(gcatgc)2 comprising the specific target site for the restriction endonuclease sph 1 is investigated by using nuclear magnetic resonance spectroscopy and restrained molecular dynamics. all the nonexchangeable proton resonances are assigned sequentially, and from time-dependent nuclear overhauser enhancement measurements a set of 158 approximate interproton distances are determined. these distances are used as the basis of a structur ...20133651407
[operation of breast milk centers in finland]. 19873649433
[congress 86. there is nothing too small to be discussed]. 20133638012
the role of the clinical environment in the translation of research into practice. 20133636224
prescription-writing with a pc.we described the development of an automated system to perform writing of prescriptions and associated advice. a prototype computer program has been in operation in a dermatologist's office for three years. all prescriptions are routinely generated using the system. the program, originally developed for a multi-user computer system, now operates in a self-contained personal computer. the program is constructed to use external human-readable files as the drug formulary or data base. experience wi ...19863634667
class d tetracycline resistance determinants of r plasmids from the fish pathogens aeromonas hydrophila, edwardsiella tarda, and pasteurella piscicida.tetracycline resistance determinants of r plasmids from the fish pathogens aeromonas hydrophila, edwardsiella tarda, and pasteurella piscicida were classified as class d by their expression of resistance to tetracycline and minocycline and through their dna structure.19873631946
thymic involvement in acute disseminated histiocytosis x. 20133628861
effect of apoe on triglyceride emulsion interaction with hepatocyte and hepatoma g2 cells.the uptake and internalization of a triglyceride emulsion by rat hepatocytes in culture less than 24 hr was either inhibited or uninfluenced by apoe. apoe significantly increased the uptake of these emulsions in later cultures. specific low density lipoprotein (ldl) binding was similar for hepatocyte monolayers prior to and after 24 hr. rat hepatocytes in culture for 2 days, which were treated with collagenase, detached and then replated within 1 hr and were apoe-responsive in 2 hr. heparin inhi ...19873625037
development changes in the human cardiac isomyosin distribution: an immunohistochemical study using monoclonal antibodies.with monoclonal antibodies (mab) specific for myosin heavy chain (mhc) isozymes, we have investigated the isomyosin content of atrial, ventricular and conductive fibers of 19 human fetuses (ranging from 14-36 weeks of gestation) and 3 newborns (2 days-2 weeks). in addition, the conduction system of 2 human adult hearts was studied. the fetal atrium is composed mostly of alpha-mhc during the first 23 weeks of gestation. beta-mhc is already expressed as traces at 14 weeks of gestation, and its exp ...19873621496
[a strain of edwardsiella tarda isolated from a patient with chronic diarrhea]. 19873621316
thermally induced disulfide bond exchanges in human ige.the thermally induced changes in human ige was investigated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. when the ige (1 mg/ml) was heated at 56 degrees c for several hours in the absence of sodium dodecyl sulfate, it gave aggregated forms that could be reduced completely to heavy and light chains with dithiothreitol. on the other hand, in the presence of sodium dodecyl sulfate (0.1%), the ige was changed by heating to five components with small mol. wts dependent on temperat ...19873614214
[effect of anaprilin on the humoral and cellular immune response].the immunosuppressive effect of anaprilin on humoral and cellular responses was established during experiments on mice. the influence of the drug on the phenomenon of hypersensitivity of delayed type begins to be revealed at the lower dose of the drug (0.5 mg/kg) as compared with the inhibitory action of the beta-adrenoblocker on antibody formation (1 mg/kg).20123609279
fracture healing perspectives. 20123595004
[medical care problems of patients with delayed consolidation]. 20133587953
yolk sac carcinoma. tumor board of the children's hospital of philadelphia. 20123587120
yolk sac carcinoma. tumor board of the children's hospital of philadelphia. 20123587120
fatal motorcycle accidents and alcohol.a series of fatal motorcycle accidents from a 7-year period (1977-1983) has been analyzed. of the fatalities 30 were operators of the motorcycle, 11 pillion passengers and 8 counterparts. of 41 operators 37% were sober at the time of accident, 66% had measurable blood alcohol concentration (bac); 59% above 0.08%. in all cases where a pillion passenger was killed, the operator of the motorcycle had a bac greater than 0.08%. of the killed counterparts 2 were non-intoxicated, 2 had a bac greater th ...20123583171
apparent unmasking of [3h]gdp binding in rat brown-fat mitochondria is due to mitochondrial swelling.the presence of and biochemical background for the so-called 'unmasking' phenomenon in rat brown-fat mitochondria was investigated (i.e. the apparent increase in [3h]gdp binding to the 'uncoupling' protein thermogenin, without a concomitant increase in the amount of the protein). it was found that an unmasking could be observed both 1 h after norepinephrine injection and after 1 h cold stress, provided that the rats were preacclimated to 28 degrees c. the unmasking could be observed both when a ...19873569283
suppression of plasma aldosterone during stimulation of cardiopulmonary mechanoreceptors in man. 19863553842
computer-aided diagnosis of dermatologic disorders.in conclusion, several computer programs have been developed to aid diagnosis in dermatology. these have used various methods to reach a diagnosis, with some earlier programs using probabilistic techniques and later programs using cognitive models. several current trends, if they continue, would indicate that computer-assisted diagnosis may play a greater role. the growing number of physicians who own the prerequisite computing resources will probably want diagnostic software to accompany their ...20133536227
prosthodontic considerations for patients with cleft lip and palate.the prosthodontist provides the final active treatment for the patient with a cleft. he must anticipate and decide upon the prosthodontic procedures in collaboration with the plastic surgeon and/or the orthodontist during the period of their interventions. the purpose of prosthodontic treatment is to prevent the relapse of the maxillary segments and the teeth after surgical and/or orthodontic correction, as well as the rehabilitation of mastication, speech and aesthetics. the individual peculiar ...20123533786
[dental aspects of bidloo's "anatomy" (1685), illustrated by lairesse and plagerized by cowper (iii)]. 20123531781
to reduce or to integrate: psychiatry's dilemma.three conceptual approaches to psychiatry may be distinguished: the somatic (biological); the psychological (psychodynamic, psychosocial); and the integrative (holistic, biopsychosocial). the first two emerged in the early nineteenth century, the third - in this century. all three continue to vie for influence today. the author traces their historical precursors and discusses their current state. he argues that psychiatrists need to apply methodological reductionism but adopt an integrative orie ...20123518907
[effects of intracranial pressure on frontal sinus development].through a study of some syndromes of intra-cranial high and low pressure, the authors try to find out the relations between the intra-cranial stresses and the development of frontal sinuses. they account for the choice of frontal sinuses and the various factors determining this pneumatization. they study the morphology of the frontal sinuses in 20 cases of old and chronic hydrocephaly, in 13 cases of oxycephaly with a late diagnosis, and in 20 cases of adults suffering with infantile cerebral he ...20123505186
[comparison of the qualities of recovery after anesthesia with propofol, methohexital and etomidate]. 20123502320
the t cell receptor: its repertoire and role in thymocyte development. 20123498291
society for pediatric radiology john caffey award. mr appearance of blood and blood products: an in vitro study.there are conflicting reports on the appearance of blood and blood clot as seen in the human body by mri. this study was designed to show the in vitro mr signal intensity of human blood products in the fresh state and to evaluate the serial mri changes that occur over time (2 weeks). t1 relaxation times were also measured. anticoagulated whole blood, plasma, serum, white blood cell concentrates, platelet concentrates, lysed red cells, red cell concentrates, and blood clot were studied. the resul ...19863486571
[pathogenesis of negative washout rate in stress thallium emission computed tomography of coronary artery disease--correlation with cine coronary angiographic findings]. 20123486404
[differentiation of the stimulating action of adrenaline and noradrenaline on oxygen consumption of the parotid gland in the rat].epinephrine and norepinephrine, but not isoproterenol, stimulated the consumption of oxygen in rat parotid gland slices in a dose dependent manner. their actions were abolished by phentolamine but propranolol had no effect. the response to epinephrine was selectively blocked by yohimbine, whereas the response to norepinephrine was inhibited by prazosin. nifedipine abolished the action of epinephrine but had no effect on norepinephrine. the findings suggest that epinephrine enhanced oxygen consum ...19873479428
immunohistochemical demonstration of pyloric gland-type cells with low-pepsinogen isozyme 1 in preneoplastic and neoplastic tissues of rat stomachs treated with n-methyl-n'-nitro-n-nitrosoguanidine.the appearance of pyloric gland-type cells with a low pepsinogen isozyme 1 (pg 1) content in the stomach mucosa of f344/du rats during stomach carcinogenesis was examined by a combination of paradoxical concanavalin a (con a) staining and immunohistochemical staining for pg 1. male f344 rats were given drinking water containing 100 micrograms n-methyl-n'-nitro-n-nitrosoguanidine [(mnng) cas: 70-25-7]/ml for 30 weeks and then normal tap water and were killed in week 10, 20, 30, 40, 50, or 70. unt ...19873470552
exocrine pancreatic neoplasms induced by methylazoxymethanol acetate in the guppy poecilia reticulata.exocrine pancreatic neoplasms developed in the guppy poecilia reticulata following a single brief exposure to methylazoxymethanol acetate [(mam-ac) cas: 592-62-1]. fish 6-10 days old were exposed to concentrations of mam-ac up to 100 mg/liter for 2 hours. exposed specimens were transferred to carcinogen-free water and sampled periodically for tumor development. pancreatic neoplasms occurred in approximately 9% of histologically examined individuals exposed to 10 mg mam-ac/liter or less. neoplast ...20123470547
design of dental equipment for remote rural and field areas.in the context of providing dental services, remote areas may be defined as those with overall low population densities; or isolated areas of low population density within more populous regions; or areas of high population density remote from dental services. the provision of equipment for remote areas is not simply a matter of extending the supply of conventional operatories to these regions. the particular needs of a region must be assessed first with equipment and instruments being selected t ...20123468078
[behavior of oxygen pressure in muscle (po2) in healthy subjects and in patients with intermittent claudication following standardized foot ergometric exercise]. 20123464140
bone marrow sinus and cell egress in human leukaemia: a morphometric study of core biopsies using wide-field electron microscopy.bone marrow biopsy specimens obtained from 24 untreated patients with several types of acute leukaemia (al) and eight patients with chronic myelocytic leukaemia (cml) were prepared without decalcification for electron microscopy. a new type of transmission electron microscope (lem 2000) was used for wide-field observation, and the venous sinuses were morphometrically evaluated on micrographs using an automatic image analyser. no differences were found between either al or cml bone marrows and th ...19863460628
a uniform image. 20123460127
in situ hybridization studies on variant t(2;8) translocations in burkitt lymphoma lines.in situ hybridization studies were performed on two burkitt lymphoma cell lines with variant t(2;8) translocation. in both cell lines the ck-gene is found in juxtaposition to the c-myc gene on the 8q+ chromosome. the location of the c-myc gene 5' of an immunoglobulin constant gene appears to be a general feature of all burkitt lymphomas. on the 2p chromosome the site of the breakpoint of the translocation is variable. in the cell line bl 64 the break is in the fragment carrying jk sequences and ...19863458667
[digestibility of macronutrients and nitrogen balance in pregnant rabbits].primiparous new zealand white does have been used to establish the weekly differences of several apparent digestibility coefficients (cda) and the nitrogen balance, between pregnant and non-pregnant does, as well as the evolution of the same parameters along the state of gestation. the intake was 180 g/animal and day at the most. the results show that protein followed by dry matter cdas were the most negatively affected in pregnant does with regard to the non-pregnant ones and throughout the ges ...19873448714
predicted time of dialysis in patients with different volumes of urea distribution--the use of mathematical model. 20123447442
inflammatory bowel disease: one condition or two?demographic data obtained from epidemiological studies of crohn's disease and ulcerative proctocolitis in regio leiden (leiden health care region) were compared. ulcerative colitis (6.8 cases/10(5) population/year) had an incidence almost twice that of crohn's disease (3.9/10(5)/year; p less than 0.001). each disease occurred with equal frequency in both sexes and diagnosis of the diseases occurred at similar ages (spearman's correlation coefficient = 0.84; p less than 0.01). where ulcerative co ...20123443227
is hypertension treated adequately?in hypertensive patients, morbidity and mortality from the malignant phase, stroke, left ventricular failure, coronary disease and progressive renal failure are closely linked to the level of blood pressure. this relationship between blood pressure and risk can be demonstrated also when blood pressure is lowered with antihypertensive agents. thus, it appears that the treated blood pressure level is a much stronger indicator of prognosis than is the initial untreated value. however, in the last 2 ...20123443056
edwardsiella tarda bacteremia. 19873436323
[basic trends and tasks of applied anatomical research today]. 20123435260
stresses and satisfactions of the two-pharmacist relationship.potential advantages and disadvantages of dual-career relationships are identified, and strategies for addressing common issues encountered by dual-career couples are presented. with regard to career issues, clarification of expectations and discussion between partners regarding career commitment, job selection and mobility, and maintenance of professional identity is emphasized. benefits of dual-career relationships include shared occupational interests, financial rewards, and respect for each ...20123434582
women in a changing profession. 20123434574
the effects of task complexity on motor performance in left and right cva patients.the effects of task complexity on movement ipsilateral to lesion were examined using the fitts tapping task [fitts, p.m., j. exp. psychol. 47, 381-391, 1954]. subjects were required to rapidly tap two targets, which were 1 or 4 cm wide. twenty controls and ten left hemisphere and nine right hemisphere stroke patients were studied. only the left hemisphere group showed significant deficits with greater impairment found in the wide target condition. quantified ct scan analyses indicated lesion vol ...20123431674
impact of pharmacist intervention on oral theophylline therapy in adult inpatients.the impact of clinical pharmacy services on the utilization of oral theophylline therapy was evaluated in a ten-week study involving 138 adult inpatients. the study initially involved an independent prospective five-week audit of theophylline use, in which clinical pharmacists monitored theophylline therapy and any interventions were designed so as not to influence future actions taken by medical officers with regard to oral theophylline therapy. the second part of the study involved active inte ...20113428141
the challenges of rural nursing. 20123426401
[burn scars of the lower extremities and chronic venous insufficiency]. 20123407224
[the use of the large saphenous vein in-situ in the treatment of ischemia of the leg and foot]. 20123406073
serum myoglobin levels in patients with ischemic myocardial insult.serum myoglobin levels were studied in 178 consecutive patients admitted for chest pain due to ischemic cardiac injury. serum myoglobin level was compared with the clinical condition, electrocardiographic changes, and serum creatine kinase levels. elevated serum myoglobin concentration was present in all patients with acute myocardial infarction, as defined by world health organization, geneva, criteria, and, in addition, in about 50% of patients with so-called acute coronary insufficiency. on t ...20123401097
civil commitment in the psychiatric emergency room. ii. mental disorder indicators and three dangerousness criteria.proponents of return to a "need for treatment" standard for civil commitment contend that the current dangerousness standard forces psychiatrists to neglect severely ill patients in favor of those who are less ill but dangerous to others. among 198 psychiatric emergency patients in five facilities, those rated as most dangerous on three ratings of involuntary admissibility, a reliable index of indicators employed by clinicians in evaluating danger to self, danger to others, and grave disability, ...20123395205
geographical variation in lymphoma incidence. 20123390384
[protein studies in cystic and peritoneal fluids of ovarian tumors with special reference to cea].the levels of total protein, ig, afp, beta-hcg, cea, sc, sp1 and alpha 2-pag were measured in cystic and peritoneal effusions obtained from 70 females with benign and malignant ovarian tumors. this study was carried out to test out parameters those are useful for tumor monitoring of ovarian cancer. our results indicate that determining cea in peritoneal effusions could be one of useful methods in tumor monitoring of mucinous cystadenocarcinomas in cases of known histology and praetherapeutic est ...20123376613
sociological and medical aspects of nutrition. 20123376489
cerebral metabolism of plasma [14c]palmitate in awake, adult rat: subcellular localization.following intravenous injection of [u-14c]palmitate in awake adult rats, whole brain radioactivity reached a broad maximum between 15-60 min, then declined rapidly to reach a relatively stable level between 4 hr and 20 hr. at 44 hr total radioactivity was 57% of the 4 hr value (p less than 0.05). about 50% of palmitate which entered the brain from the blood was oxidized rapidly, producing 14c-labeled water-soluble components which later left the cytosol. radioactivity in the cytosolic fraction p ...19883368026
court-ordered vs. voluntary treatment of abusive and neglectful parents.the effects of voluntary vs. court-mandated participation in a comprehensive child abuse and neglect treatment program were compared. the treatment program offered therapeutic family day care for the children of preschool age, group sessions for the parents, and home treatment for the entire family. the impact of the program was noted in the quality of the affective interaction between parents and children and disciplinary methods used, among other measures. families in voluntary and court-order ...20113365581
evaluation of prostaglandins as mediators of tubuloglomerular feedback.orthograde and retrograde microperfusion experiments were conducted in sprague-dawley rats to evaluate the participation of vasoconstrictive eicosanoids as mediators of tubuloglomerular feedback (tgf) signals. retrograde perfusion with 160 microm arachidonic acid (aa) added to a hypotonic solution enhanced the stop-flow pressure (sfp) feedback responses compared with those obtained with the control hypotonic solution (delta sfp, 1.6 +/- 0.4 vs. 10.1 +/- 0.7 mmhg with aa). blockade of thromboxane ...19883364575
the electroencephalogram and acute ischemic stroke. distinguishing cortical from lacunar infarction.one hundred consecutive cases of clinically diagnosed, acute forebrain infarction were studied using computerized tomography (ct) and electroencephalography (eeg). computed tomography confirmed brain infarction in 91 patients and was normal in the remaining nine. each eeg was read independently by two experienced electroencephalographers without knowledge of ct or clinical details and their findings were compared with those of ct. lateralized theta and/or delta activity predicted ipsilateral cor ...20123358704
hypothermia and the action of neuromuscular blocking agents. 20123354819
[erythema nodosum and brucellosis]. 20123352359
anti-inflammatory activity of oleoresin from brazilian copaifera.the oleoresin from brazilian copaifera species yielded copalic acid and sesquiterpenes and showed marked anti-inflammatory activity using various experimental models in rats. the oleoresin significantly inhibited carrageenin-induced pedal edema following oral doses from 0.70 to 2.69 ml/kg, but was somewhat less effective than 50 mg/kg calcium phenylbutazone. repeated administration of the oleoresin at a dose of 1.26 ml/kg for a 6-day period reduced granuloma formation with a response comparable ...19883352280
sinus arrest associated with clonidine therapy.a 65-year-old male with diabetes, hypertension, and mild renal failure developed dizziness and syncope one week after starting clonidine 0.45 mg/day. a continuous ecg recording revealed sinus bradycardia, nodal rhythm, and multiple episodes of sinus arrest lasting up to 4.5 seconds. upon discontinuation of clonidine, serial continuous ecg recordings revealed gradual decrease in the number and duration of the sinus arrest episodes, until their complete disappearance shortly after the third day of ...20123349661
interaction of glucocorticoid receptor from rat liver with protamine and arginine.the nontransformed glucocorticoid receptor (gr) from rat liver was found to bind to protamine-sepharose and could be recovered by a salt gradient without a change in molecular configuration. the nontransformed gr also bound to arginine-sepharose, but the transformed gr did not bind to either resin. ligand-free gr interacted with both resins and was eluted without loss of its steroid binding ability. the bindings of gr to protamine- and arginine-sepharose were saturable. the apparent dissociation ...19883347046
13c nmr studies of carboxylate inhibitor binding to cobalt(ii) carboxypeptidase a.both 13c nmr and electronic absorption spectral studies on cobalt(ii) carboxypeptidase a in the presence of acetate and phenylacetate provide evidence for two binding sites for each of these agents. the transverse relaxation rate t2-1 for the 13c-enriched carboxyl groups of the inhibitors is significantly increased when bound to the paramagnetic cobalt carboxypeptidase as compared to the diamagnetic zinc enzyme. the acetate concentration dependence of t2p-1 shows two inflections indicative of se ...20123346659
iowa emergency medical services: funding the future. iowa department of public health. 20123346141
topical ocular drug delivery: recent developments and future challenges.existing ocular drug delivery systems are fairly primitive and inefficient, but the stage is set for the rational design of newer and significantly improved systems. the focus of this review is on recent developments in topical ocular drug delivery systems relative to their success in overcoming the constraints imposed by the eye and to the improvements that have yet to be made. in addition, this review attempts to place in perspective the importance of pharmacokinetic modeling, ocular drug phar ...19863332284
hemosorption and other efferent methods in medicine. 20123329539
assessing the effects of psychotherapy. i. analysis and critique of present conventions of estimating change.the use of the difference between pre- and posttherapy status as an estimate of change and of the regression transformation as an adjustment for initial status variation is discussed in reliability and scaling terms. also, the quantitative view of psychotherapeutic change implied by difference scores is set in contrast to a qualitative view of change as inner (re)structuring. further, it is argued that psychotherapeutic goals should be conceived in terms of metapsychology rather than as the acqu ...20123326019
economic rights of the institutionalized mentally disabled. 20113319919
sepiapterin reductase in cultured human cells.sepiapterin reductase, an enzyme involved in the synthesis of tetrahydrobiopterin (the natural cofactor for phenylalanine, tyrosine and tryptophan hydroxylases), has been assayed in cultured human amniotic fibroblasts and in cultured mononuclear blood cells. in both cases, the michaelis constants for sepiapterin and nadph were essentially equal; 20 microm and 6 microm respectively for stimulated mononuclear blood cells and 22 microm and 5 microm respectively for amniotic fibroblasts. the inhibit ...19873318833
arteriolar oxygen reactivity: where is the sensor?the hypothesis that arterioles are intrinsically sensitive to oxygen was tested by comparing arteriolar diameter responses with local and global po2 changes in superfused hamster cheek pouch preparations. local po2 changes were produced by microapplication of fluid onto the surface of occluded or unoccluded aparenchymal arterioles or by cannulation and perfusion of arterioles in situ. global changes refer to po2 changes in the superfusate flowing over the entire preparation. local, effective po2 ...20123318502
[hypoglycemic syndrome of auto-immune origin]. 20123302474
glomerulonephritis, b monoclonal small lymphocytic lymphoma and mixed cryoglobulinemia.a novel association in the same patient with small lymphocytic lymphoma, type ii cryoglobulinemia and glomerulonephritis is reported. this case is also characterized by a quite unusual sequence of glomerular alterations. a first renal biopsy showed severe endocapillary proliferative glomerulonephritis due to monocytic infiltration without any evidence of deposition of immune reactants. the immune deposits associated with type ii cryoglobulinemia were only observed at a second renal biopsy perfor ...20123297440
common evolutionary origin of the ilvgmeda attenuation locus and trna(1leu) in escherichia coli.published sequences of transcripts from ilvgmeda leader regions of several enteric bacteria were compared with published sequences of the trnas from escherichia coli. the analyses revealed homology between the ilvgmeda leader peptide-coding region and trna(1leu) in e. coli, salmonella typhimurium, and klebsiella aerogenes, whereas homology was not present in serratia marcescens and edwardsiella tarda.19873294812
comparative biology of test species.this paper assesses the capacity of animal models to predict human response to carcinogenic agents with consideration for the heterogeneity of humans. it is widely accepted that human susceptibility to toxic substances, including carcinogens, is highly variable. conventional rodent models are usually highly inbred and valued for their ability to display characteristic homogeneity. current practice assumes that the homogeneity of response to toxic agents, including carcinogens, in the rodent mode ...19883289908
contamination of freshly slaughtered pig carcasses with human pathogenic yersinia enterocolitica.evidence is presented for the extent of contamination of freshly slaughtered pig carscasses with human pathogenic yersinia enterocolitica and shows the significance of faecal contamination as a source of infection. swab samples collected from the rectum and the surface of a total of 1458 pig carcasses were examined for the presence of human pathogenic y. enterocolitica. y. enterocolitica, biovar iv, serogroup 0:3, were isolated from the rectum of 360 pigs (24.7%). the organism was isolated from ...19883275322
[medium-term results of radial keratotomies and discussion]. 20123269275
effect of recent antibacterial agents against bacteria causing diarrhoea.the susceptibility of 424 bacterial isolates causing diarrhoea were tested by agar dilution technique on mueller-hinton agar against amoxicillin, ampicillin, ceftriaxone, chloramphenicol, co-trimoxazole, ciprofloxacin, doxycycline, norfloxacin and ofloxacin. the bacterial species included were aeromonas hydrophila, edwardsiella tarda, pleisomonas shigelloides, salmonella spp., shigella spp., vibrio cholerae and vibrio parahaemolyticus. the most active compounds were the fluorinated 4-quinolones ...19883266900
interleukin 4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma.addition of il-4 (1,000 u/ml) to either high or low concentrations of il-2 augmented tumor-infiltrating lymphocytes (til) growth from human melanoma. weekly restimulation with irradiated tumor cells in conjunction with il-4 allowed enhanced growth of til. with low-dose il-2 (10 u/ml) and il-4, expanded til had little cytolytic activity against daudi or allogeneic tumors. further, il-4 augmented the total lytic activity against autologous tumors in most cases. with high-dose il-2 (1,000 u/ml), il ...19883264324
t cell recognition of bovine ribonuclease. self/non-self discrimination at the level of binding to the i-ak molecule.bovine rnase a specific t-cell hybridomas were generated to study the recognition of foreign ag by t lymphocytes. one hybrid, ts12, was shown to recognize rnase in association with i-ak. this hybridoma required bovine rnase to be processed before recognition. the immunogenic determinant on the rnase molecule recognized by ts12 was localized to the tryptic fragment rnase(40-61). all of the stimulatory ability of this determinant was shown to be contained within the synthetic 14mer rnase(43-56). w ...19883264304
[aids. revolt against physicians who ought to get away from nurses. interview by grethe kjaergaard]. 20123256090
edwardsiella tarda serotyping scheme for international use.a combination of two systems for the serotyping of edwardsiella tarda developed independently at the national institute of health, tokyo, japan, and the centers for disease control, atlanta, ga., has enabled a single serotyping scheme comprising 61 o groups and 45 h antigens to be established for international use.19883235660
hemobilia due to ruptured hepatic artery aneurysm. 20113235180
karyological studies in coris julis (pisces, labridae).in the present investigation the diploid number 2n = 48 (nf = 58) has been determined for females, primary males, and secondary males of coris julis from the gulf of palermo. differentiated sex chromosomes have not been observed in the population under study.20113234765
neonatal sepsis and meningitis caused by edwardsiella tarda. 19883231505
metasternal gland secretion of the locust tree borer, megacyllene robiniae (coleoptera: cerambycidae).1. the volatile components of metasternal gland extracts of male and female megacyllene robiniae have been analyzed by gas chromatography-mass spectroscopy. 2. the major component was identified as 2-(1,3-hexadien-1-yl)-5-methyltetrahydrofuran, a new natural product. 3. 1-phenylethanol is present only in male extracts. 4. acetates of hexadecanol and octadecanol are also present.20113224513
hiv-1 seroprevalence in male prostitutes in northeast italy. 19883216323
[status quo in lipid diagnosis from the internal medicine viewpoint. discussion of the contribution of the same title by w. reuter in z. gesamte inn. med. 43 (1988) 71-74]. 20113213119
silicone as a trace contaminant in laboratory solvents.this paper examines a suite of lipid solvents for their utility as solvents for silicone analysis by raman spectroscopy, and discusses the observation that off-the-shelf reagents could be contaminated by silicone during manufacture. of the solvents examined, only chloroform was transparent in those spectral regions (chiefly 500 cm-1) in which silicone exhibits its raman spectrum. also, the chloroform examined showed evidence of silicone contamination. therefore, chloroform is suggested as a suit ...20113212449
cd of ethidium bromide complexes with normal and electrophoretically anomalous dna restriction fragments. 20113207850
[infertility and chlamydia infection]. 19883206475
inhibitory activity of antibiotic-producing marine bacteria against fish pathogens.the activity of antibiotic-producing marine bacteria was assayed against bacterial fish pathogens belonging to the genera vibrio, aeromonas, pasteurella, edwardsiella, yersinia and pseudomonas with the aim of evaluating the possible use of these marine strains for controlling epizootics in aquaculture. inhibition tests on solid medium showed that, in general, the majority of fish bacteria were strongly sensitive to the marine bacteria. only two strains (edwardsiella tarda and pseudomonas aerugin ...19883204073
hepatotoxic and hepatoprotective potential of histamine (h2)-receptor antagonists. 20113195618
effect of bromoethylamine hydrobromide on systemic acid-base balance.intravenous administration of bromoethylamine hydrobromide (bea) has been shown to induce papillary necrosis of the kidney. we used this model to clarify the role of the medullary structure in acid-base homeostasis. bea (25 mg) or vehicle was injected to male sprague-dawley rats. blood specimens and 24 hr urine were collected once a week totaling 4 weeks. blood bicarbonate significantly decreased in bea treated rats with no change in plasma creatinine or creatinine clearance at 3 and 4 weeks, we ...19883194903
effect of synthetic thrombin inhibitor (md805) as an alternative drug on heparin induced thrombocytopenia during hemodialysis. 20113194891
edwardsiella tarda septicemia complicating acute leukemia.we describe here an unusual case of edwardsiella tarda septicemia preceded by acute gastroenteritis in a patient with acute leukemia in complete remission receiving maintenance chemotherapy. she also had ulcerated rectal cancer with bleeding, which was thought to serve as the portal of entry into the blood stream. she was successfully treated with cefmetazole and gentamicin in combination. however, the concomitant resolution of chemotherapy-induced granulocytopenia may have had a favorable effec ...19883193663
muscle function in women with rheumatoid arthritis--the influence of glucocorticosteroids. a clinical and morphological investigation. 20113187461
compulsory continuing dental education. 20113166118
[low doses of subcutaneous cytosine arabinoside in the treatment of patients with myelodysplastic syndromes]. 20113165541
yeast activators stimulate plant gene expression.gal4 is a transcriptional activator found in yeast. two distinct functions of the protein are required for its activity: one directs sequence-specific dna binding, and another interacts with some other component of the transcriptional machinery, for example, rna polymerase ii or a tata-binding protein. two short regions of gal4 function as 'activating sequences' when attached to the dna-binding portion of gal4 and these regions can be replaced by a large number of peptides encoded by escherichia ...19883165494
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