Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| naturally occurring systemic immune responses to hpv antigens do not predict regression of cin2/3. | essentially all squamous cervical cancers and their precursor lesions, high grade cervical intraepithelial neoplasia (cin2/3), are caused by persistent human papillomavirus (hpv) infection. however, not all cin2/3 lesions progress to cancer. in a brief, observational study window monitoring subjects with cin2/3 from protocol entry (biopsy diagnosis) to definitive therapy (cervical conization) at week 15, in a cohort of 50 subjects, we found that 26% of cin2/3 lesions associated with hpv16, the g ... | 2010 | 20012604 |
| human papillomavirus types 16 and 18 mrna levels and not dna levels may be associated with advancing stages of cervical cancer. | human papillomavirus (hpv) contributes to the development of cervical cancer. we hypothesize that hpv dna and messenger rna (mrna) levels may be associated with increasing stages of cervical cancer. | 2009 | 20009900 |
| invited commentary: human papillomavirus infection and risk of cervical precancer--using the right methods to answer the right questions. | epidemiologists are well aware of the negative consequences of measurement error in exposure and outcome variables to their ability to detect putative causal associations. however, empirical proof that remedying the misclassification problem improves estimates of epidemiologic effect is seldom examined in detail. of all areas in cancer epidemiology, perhaps the best example of the consequences of misclassification and of the steps taken to circumvent them was the pursuit, beginning in the mid-19 ... | 2010 | 20007675 |
| an analysis of the human papilloma virus vaccine debate on myspace blogs. | the roll out of hpv immunization programs across the united states was hindered by controversy. we tracked the debate in the united states through myspace, then the most popular social networking site, in order to better understand the public's reaction to the vaccine. | 2010 | 20003922 |
| integrating clinical, community, and policy perspectives on human papillomavirus vaccination. | infection with genital human papillomavirus (hpv) may cause anogenital cancers, oropharyngeal cancers, anogenital warts, and respiratory papillomas. two prophylactic vaccines (a bivalent and a quadrivalent vaccine) are now licensed and currently in use in a number of countries. both vaccines prevent infection with hpv-16 and hpv-18, which together cause approximately 70% of cervical cancers, and clinical trials have demonstrated 90%-100% efficacy in preventing precancerous cervical lesions attri ... | 2010 | 20001821 |
| [expression of gelatinases a and b and their endogenous regulators in immortal and transformed fibroblasts]. | matrix metalloproteinases (mmp) play a critical role in tumor invasion and metastasis. the aim of this study was to elucidate peculiarity of expression of gelatinases a and b (mmp-2 and mmp-9), membrane type mmp (mt1-mmp) and tissue inhibitor of mmp (timp-2) in immortal (if) and transformed fibroblasts (tf).the study was carried out using embryo rat fibroblasts, sequentially immortalized with the polyomavirus lt gene and transformed with the e7 gene of human papilloma virus (hpv-16). papilloma v ... | 2009 | 20000122 |
| the role of human papillomavirus testing in cervical cancer screening. | 2009 | 19999172 | |
| hpv in adolescents. making the wake-up call. | 2007 | 19998883 | |
| bowen's disease of the nail matrix presenting as melanonychia: detection of human papillomavirus type 56. | 2009 | 19997699 | |
| human papilloma virus and female lung adenocarcinoma. | lung cancer is the leading cause of cancer among women worldwide, and adenocarcinoma is the most common histological subtype among non-smoking women. previous studies showed that human papillomavirus (hpv) infection may relate to the tumorigenesis of pulmonary adenocarcinoma. women with anogenital malignancy have a higher risk of lung cancer, which raises the possibility of hpv transmission from the cervix to the lung. two postulated pathways are discussed in this work. first, hpv may infect the ... | 2009 | 19995646 |
| should boys receive the human papillomavirus vaccine? yes. | 2009 | 19969602 | |
| appendix to: "pcr detection rates of high risk human papillomavirus dna in paired self-collected urine and cervical scrapes after laser co(2) conization for high-grade cervical intraepithelial neoplasia". | 2010 | 19969337 | |
| [preparation and identification of type specific and conformation dependent hpv16 l1 protein monoclonal antibody.]. | to generate type specific and conformation dependent monoclonal antibodies against human papillomavirus 16 major capsid l1 protein (hpv16 l1). | 2009 | 19961800 |
| type-specific human papillomavirus oncogene messenger rna levels correlate with the severity of cervical neoplasia. | this study aimed to evaluate whether quantitation of high-risk human papillomavirus (hr-hpv) e6 messenger rna (mrna) can be a potential biomarker for detecting the severity of cervical lesions. hpv genotyping was performed using a modified my11/gp6+ pcr for hpv dna amplification, followed by hpv genotype-specific hybridization with on a gene chip. e6 type-specific pcr was used to validate multiple infections. quantitative real-time reverse transcriptase (qrt-pcr) and real-time pcr used to measur ... | 2010 | 19960432 |
| interaction of immunological genes on chromosome 2q33 and ifng in susceptibility to cervical cancer. | cervical cancer is caused by persistent infection with human papillomavirus and genetic susceptibility factors may augment disease risk. the immune response consists of complex interactions and it was recently proposed that the association of combinations of genotypes at several genes should be examined. in support of this the combination cd28+17(tt)/ifng+874(aa) was shown to increase cervical cancer risk in a brazilian population (vb guzman et al. new approach reveals cd28 and ifng gene interac ... | 2010 | 19959217 |
| [effect of hpv16e6 on sensitivity of chemotherapy for cervical carcinoma in different p53 genotype cell lines]. | to investigate the effect of human papillomavirus types 16e6 on the sensitivity of chemotherapy for cervical carcinoma in different p53 genotype cell lines. | 2009 | 19952400 |
| human papillomavirus knowledge and vaccine acceptability among a national sample of heterosexual men. | if approved for use in young males in the united states, prophylactic human papillomavirus (hpv) vaccine may reduce the incidence of hpv-related disease in vaccinated males and their sexual partners. we aimed to characterise heterosexual men's willingness to get hpv vaccine and identify correlates of vaccine acceptability. | 2010 | 19951936 |
| hpv vaccine acceptance among latina mothers by hpv status. | we investigated whether latina mothers who were and were not human papillomavirus (hpv) positive differed in their knowledge and acceptance of the hpv vaccine for their children. | 2009 | 19951213 |
| adherence to cervical cancer screening guidelines for u.s. women aged 25-64: data from the 2005 health information national trends survey (hints). | although it is widely accepted that papanicolaou (pap) screening can reduce cervical cancer mortality, many women still do not maintain regular cervical cancer screenings. | 2009 | 19951209 |
| persistent antibodies to hpv virus-like particles following natural infection are protective against subsequent cervicovaginal infection with related and unrelated hpv. | whether persistent human papillomavirus (hpv) igg antibodies following natural infection are protective against subsequent infection is unknown. in a cohort of 508 college women followed for 3 y, persistent seropositivity was defined as the presence of type-specific hpv virus-like particle (vlp) antibodies at > or = 2 consecutive visits 1 y apart. protection from incident infection with any hpv was conferred by persistent antibodies to hpv16 (p = 0.02), hpv31 (p < 0.001), hpv33 (p = 0.03), hpv35 ... | 2009 | 19951181 |
| enhancing the scope of conventional cervical cytology for detecting hpv infection. | cervical neoplasia is attributed to a persistent human papilloma virus infection. the pap smear being the mainstay of cervical cancer screening in low-resource settings, we studied the nonclassical features which might indicate hpv infection. these included abortive koilocytes, mild dyskeratosis, parakeratosis, mild nuclear hyperchromasia, bi/multinucleation, measles cells, and keratohyaline-like granules. two hundred and eight women with a satisfactory pap smear and a hybrid capture ii test wer ... | 2010 | 19950400 |
| immunization for hiv-positive individuals. | this review summarizes recent literature addressing immunization in the setting of hiv infection, with a specific focus on emerging evidence that can guide the care of hiv-positive adults. | 2010 | 19949327 |
| causes of oral cancer--an appraisal of controversies. | major risk factors for oral cancer are cigarette smoking and alcohol misuse. among asian populations, regular use of betel quid (with or without added tobacco) increases oral cancer risks. dentists should be aware of some emerging risk factors for oral, and particularly oropharyngeal cancer such as the role of the human papillomavirus infection (hpv). decreases in risk could be achieved by encouraging high fruit and vegetable consumption. some controversies related to the aetiology of this disea ... | 2009 | 19946320 |
| currently approved prophylactic hpv vaccines. | cervarix and gardasil are two prophylactic hpv vaccines designed primarily for cervical cancer prevention. cervarix is effective against hpv-16, -18, -31, -33 and -45, the five most common cancer-causing types, including most causes of adenocarcinoma for which we cannot screen adequately. gardasil is effective against hpv-16, 18 and 31, three common squamous cell cancer-causing types. in addition, gardasil is effective against hpv-6 and -11, causes of genital warts and respiratory papillomatosis ... | 2009 | 19943762 |
| anal-rectal cytology: a review. | the incidence of invasive anal squamous cell carcinoma, a human papilloma virus (hpv) related cancer, is on the rise, especially in hiv positive men who have sex with men (msm). like cervical cancer, anal cancer is associated with precursor lesions detectable on exfoliative cytology as squamous intraepithelial lesions and on biopsy as intraepithelial neoplasia. anal-rectal cytology screening programs, similar to cervical cytology screening programs, have been developed in an effort to detect and ... | 2010 | 19941374 |
| an analysis on the combination expression of hpv l1 capsid protein and p16ink4a in cervical lesions. | human papillomavirus (hpv) infection in cervix is the most important reason for cervical cancer, but only 2% cervical hpv infection will develop into cervical cancer. so how to identify patients at risk of progressive cervical lesions from those infected with hpv to avoid over treatment is a big issue in clinic. the aims of this study were to detect the expression of hpv l1 capsid protein and p16(ink4a) in cervical lesions and to investigate the combination expression of hpv l1 capsid protein an ... | 2010 | 19941368 |
| annual disease burden due to human papillomavirus 16 and 18 infections in finland. | apart from cancers of the lower female genital tract, human papillomaviruses (hpv) are associated with a large number of benign, premalignant and malignant lesions at different anatomic sites in both genders. malignant tumours and their precursors are usually attributed to the oncogenic (high-risk, hr) hpv types, whereas benign lesions (mostly papillomas) are ascribed to the low-risk (lr) hpv types, most notably hpv6 and hpv11. to date, the main interest has been focused on hr-hpv types and thei ... | 2009 | 19939209 |
| human papillomavirus prevalence and cytopathology correlation in young ugandan women using a low-cost liquid-based pap preparation. | screening for hpv-driven cervical dysplasia and neoplasia is a significant public health concern in the developing world. the purpose of this study was to use a manual, low-cost liquid-based pap preparation to determine hpv prevalence in hiv-positive and hiv-negative young women in kampala, uganda and to correlate cervical cytopathology with hpv-dna genotype. about 196 post-partum women aged 18-30 years underwent rapid hiv testing and pelvic examination. liquid-based cervical cytology samples we ... | 2010 | 19937939 |
| update on quadrivalent human papillomavirus vaccination and pregnancy outcomes: is contraception advisable? | 2009 | 19935015 | |
| prevalence of sexually transmitted infections among female adolescents aged 14 to 19 in the united states. | most young women initiate sexual activity during adolescence; risk for sexually transmitted infections (stis) accompanies this initiation. in this study we estimated the prevalence of the most common stis among a representative sample of female adolescents in the united states. | 2009 | 19933728 |
| assessing knowledge of human papillomavirus and collecting data on sexual behavior: computer assisted telephone versus face to face interviews. | education campaigns seeking to raise awareness of human papillomavirus (hpv) and promoting hpv vaccination depend on accurate surveys of public awareness and knowledge of hpv and related sexual behavior. however, the most recent population-based studies have relied largely on computer-assisted telephone interviews (cati) as opposed to face to face interviews (ftfi). it is currently unknown how these survey modes differ, and in particular whether they attract similar demographics and therefore le ... | 2009 | 19930668 |
| high level protein expression in plants through the use of a novel autonomously replicating geminivirus shuttle vector. | we constructed a novel autonomously replicating gene expression shuttle vector, with the aim of developing a system for transiently expressing proteins at levels useful for commercial production of vaccines and other proteins in plants. the vector, pric, is based on the mild strain of the geminivirus bean yellow dwarf virus (beydv-m) and is replicationally released into plant cells from a recombinant agrobacterium tumefaciens ti plasmid. pric differs from most other geminivirus-based vectors in ... | 2010 | 19929900 |
| hpv vaccine protein l1 predicts disease outcome of high-risk hpv+ early squamous dysplastic lesions. | prediction of the clinical outcome of nonadvanced, early dysplastic lesions is one of the unresolved problems of cervical cancer screening programs. we examined the influence of human papillomavirus (hpv) l1 capsid protein detection in a randomized, prospective study of 187 high-risk hpv+ early dysplastic lesions during 36 to 46 months. the difference in the clinical outcome of the hpv l1- cases and the hpv l1+ cases was highly statistically significant (p < .0001) and independent of the classif ... | 2009 | 19926574 |
| eligibility and willingness of first-year students entering university to participate in a hpv vaccination catch-up program. | in france, human papillomavirus (hpv) vaccine is routinely recommended for 14-year-old girls; a catch-up vaccination should be offered to girls and women 15-23 years of age before the first time they have sex or within the first year after sexual activity begins. the aim of the present study was to examine the eligibility and willingness of first-year college students of toulouse university (france) to participate in a hpv vaccination catch-up program, and to estimate their knowledge of hpv vacc ... | 2010 | 19926199 |
| formation of 8-nitroguanine, a nitrative dna lesion, in inflammation-related carcinogenesis and its significance. | chronic infection and inflammation contribute to a substantial part of environmental carcinogenesis. recently, it has been estimated that chronic inflammation accounts for approximately 25% of cancer cases. various infectious diseases and physical, chemical, and immunological factors participate in inflammation-related carcinogenesis. under inflammatory conditions, reactive oxygen and nitrogen species, which are generated from inflammatory and epithelial cells, may play an important role in carc ... | 2009 | 19921494 |
| a 25-year analysis of veterans treated for tonsillar squamous cell carcinoma. | to determine the recurrence and survival outcome based on treatment date, type of treatment, stage of disease, and comorbidity and the recurrence and survival differences based on smoking status as a surrogate for human papillomavirus status in veterans treated for tonsillar squamous cell carcinoma (scc). | 2009 | 19917929 |
| substituted tetrahydro-beta-carbolines as potential agents for the treatment of human papillomavirus infection. | the identification and optimization of a series of substituted tetrahydro-beta-carbolines with potent activity against human papillomavirus is described. structure-activity studies focused on the substitution pattern and chirality of the beta-carboline ring system are discussed. optimization of these parameters led to compounds with antiviral activities in the low nanomolar range. | 2010 | 19914830 |
| biomarkers in cervical screening: quantitative reverse transcriptase pcr analysis of p16ink4a expression. | molecular insights into the human papillomavirus (hpv)-induced cervical carcinogenesis led to the discovery of biomarkers for cervical disease. the detection of cellular proteins that are overexpressed by hpv-infected cells, such as tumor suppressor protein p16(ink4a), might play an important role in future cervical cancer screening strategies. p16(ink4a) immunostaining correlates with the severity of cytological and histological abnormalities, but shows some methodological shortcomings such as ... | 2010 | 19910796 |
| prevalence of human papillomavirus genotypes, and mucosal iga anti-viral responses in women with cervical ectopy. | data on the prevalence of different human papillomavirus (hpv) genotypes and the associated mucosal immune response in women with cervical ectopy are scarce. | 2010 | 19906557 |
| women with hiv are more commonly infected with non-16 and -18 high-risk hpv types. | to review and summarize evidence from clinical, translational and epidemiologic studies which have examined the clinically relevant aspects of hpv type prevalence and cervical dysplasia in hiv-infected women. | 2010 | 19906410 |
| age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized setting. | human papillomavirus (hpv) dna testing has shown higher sensitivity than cytology for detecting cervical lesions, but it is uncertain whether the higher sensitivity is dependent on the age of the woman being screened. we compared the age-specific performance of primary hpv dna screening with that of conventional cytology screening in the setting of an organized population-based cervical cancer screening program in finland. | 2009 | 19903804 |
| selective targeting of hpv-16 e6/e7 in cervical cancer cells with a potent oncolytic adenovirus and its enhanced effect with radiotherapy in vitro and vivo. | recent studies have shown that oncolytic adenovirus specifically targeted tumor cells while sparing normal cells. here, we report a novel e1a-mutant adenovirus (m6) with antisense hpv16 e6 e7 dna inserted into the deleted 6.7k/gp19k region of e3. the target effects of m6 on hpv16-positive cervical cancer cells were evaluated in vivo and in vitro. by using cytopathic effect (cpe) and viral replication assays, we verified m6 was competent to selectively replicate in cervical cancer cells in vitro. ... | 2010 | 19903581 |
| development of a soluble ptd-hpv18e7 fusion protein and its functional characterization in eukaryotic cells. | though accumulated evidence has demonstrated the transformation capacity of human papillomavirus (hpv) type 18 protein e7, the underlying mechanism is still arguable. developing a protein transduction domain (ptd)-linked e7 molecule is a suitable strategy for assessing the biological functions of the protein. in the present study, hpv18 e7 protein fused to an n-terminal ptd was expressed in the form of glutathione s-transferase fusion protein in escherichia coli with pgex-4t- 3 vector. after glu ... | 2009 | 19902124 |
| human papillomavirus vaccines: current issues & future. | cervical cancer is the leading cause of cancer mortality among women in worldwide. some 99 per cent of cervical cancer cases are linked to genital infection with human papillomaviruses (hpvs) comprised of approximately 15 oncogenic genital hpv types. most hpv infections resolve spontaneously. but, the remainder persist and may then progress to cervical cancer in some women. in high-resource countries, the best way to prevent cervical cancer is to implement organised gynaecological screening prog ... | 2009 | 19901444 |
| human papillomavirus infection, cancer & therapy. | infection with human papillomaviruses (hpvs) is a major public health burden worldwide and is associated with a variety of epithelial lesions, including benign warts and several types of anogenital tumours, particularly cervical carcinoma. from available data it is clear that members of the hpv family are important human pathogens. prevention or elimination of these infections would not only benefit the numerous patients with benign lesions, but ultimately should reduce the incidence of cervical ... | 2009 | 19901437 |
| genotypes of the human papillomavirus: relevance to indian field trials of the vaccine. | highly effective hpv vaccines are likely to become available for use in india shortly. the availability and validation of the vaccines to prevent oncogenic hpv infection associated lesions from progressing to cancer has clearly offered a cost effective long-term strategy to reduce the cervical cancer burden, particularly for developing countries where effective screening programmes are not available. the enthusiasm for these new vaccines duly justified, are we in reality targeting the actual del ... | 2009 | 19901434 |
| human papillomavirus infection (hpv) & screening strategies for cervical cancer. | the incidence of cervical cancer is declining slowly necessitating concerted and organized control measures. control through primary prevention has become a distinct reality though a prophylactic vaccine, which may take quite some time for its widespread use. thus control of cervical cancer through secondary preventive measures is the only viable solution now. while high quality cytology screening may not be feasible for widescale implementation in developing countries because of lack of necessa ... | 2009 | 19901432 |
| infection of human papillomaviruses in cancers of different human organ sites. | clinico-epidemiological and molecular studies have established the casual link between human papillomavirus (hpv) infection and cervical cancer as also association of hpv infection with several other cancers. in india, cervical cancer is a leading cancer among women and almost all cases of cervical cancer show prevalence of high risk (hr)-hpv infection. hpv has been also detected in a significant proportion of oral, esophageal, anal, vaginal, vulvar, and penile cancer and in a small percentage o ... | 2009 | 19901431 |
| production of immunogenic human papillomavirus-16 major capsid protein derived virus like particles. | recombinant dna technology allows expression of the human papillomavirus (hpv) major capsid protein (l1) in heterologous expression systems and the recombinant protein self assembles to virus-like particles (vlp). we took up this study to produce recombinant hpv-16 l1 in yeast, establish the process of recombinant l1 derived vlp preparation and develop an elisa using vlp as the antigen for serological evaluation of anti hpv-16 l1 antibody status. | 2009 | 19901429 |
| no evidence for a pathogenic role of human papillomavirus infection in ocular surface squamous neoplasia in germany. | the etiology of ocular surface squamous neoplasia is unknown. possible etiologic factors are physical and/or viral damage by human papillomavirus (hpv), especially in sub-saharian populations. this study focused on the presence of human papillomavirus in ocular surface squamous neoplasia in comparison to pterygia and normal conjunctiva. | 2009 | 19899994 |
| cost-effectiveness analysis of human papillomavirus (hpv) vaccination in the netherlands: recent publication reinforces favorable cost-effectiveness despite misleading conclusion. | 2010 | 19896454 | |
| women >or=30 years of age with low grade squamous intraepithelial lesion (lsil) have low positivity rates when cotested for high-risk human papillomavirus: should we reconsider hpv triage for lsil in older women? | high-risk human papillomavirus (hr-hpv) testing for colposcopy triage of low grade squamous intraepithelial lesion (lsil) is not recommended because of high positive rates in young women. it remains unclear whether hr-hpv testing may be useful for triage of older women. we compiled hr-hpv data for women aged >or=30 years with lsil for the period march 1, 2006 to february 28, 2008. follow-up cervical biopsy information was collected for the period march 1, 2006 to august 15, 2008. we used the hyb ... | 2010 | 19894254 |
| human papillomavirus genotypes in invasive cervical cancer in jordan. | 2010 | 19892334 | |
| artistic: a randomised trial of human papillomavirus (hpv) testing in primary cervical screening. | primary cervical screening uses cytology to detect cancer precursor lesions [cervical intraepithelial neoplasia stage 3 or beyond (cin3+)]. human papillomavirus (hpv) testing could add sensitivity as an adjunct to cytology or as a first test, reserving cytology for hpv-positive women. this study addresses the questions: does the combination of cytology and hpv testing achieve a reduction in incident cin3+?; is hpv testing cost-effective in primary cervical screening?; is its use associated with ... | 2009 | 19891902 |
| erythema multiforme following vaccination for human papillomavirus. | erythema multiforme (em) is an acute self-limited immune-mediated reaction manifested by target skin lesions with mucous membrane involvement. the most common causes are infections and drugs. vaccinations have been reported as a triggering factor, and they may be a frequent cause of em in childhood. a 19-year-old female developed several target lesions of the hands and feet 10 days after the second dose of human papillomavirus (hpv) vaccine. clinico-histologically, a diagnosis of em minor was ma ... | 2010 | 19887766 |
| association of cystic neck metastases and human papillomavirus-positive oropharyngeal squamous cell carcinoma. | human papillomavirus is an established cause of oropharyngeal squamous cell carcinoma. similar to cervical cancer, these cancers are usually caused by high-risk human papillomavirus types 16 and 18 and are associated with high-risk sexual behaviors. human papillomavirus-associated oropharyngeal squamous cell carcinoma typically affects the palatine and lingual tonsils and frequently results in cystic neck metastases. the histopathology of this subset of head and neck squamous cell carcinoma is u ... | 2009 | 19886714 |
| vaccinate or not? poep says physicians don't always suggest hpv vaccine. | even though the human papillomavirus vaccine has preventive benefits, a texas medical association survey shows texas physicians are slow to recommend it consistently to their young female patients. | 2009 | 19885756 |
| actual vs preferred sources of human papillomavirus information among black, white, and hispanic parents. | 2009 | 19884601 | |
| comparative prognostic value of hpv16 e6 mrna compared with in situ hybridization for human oropharyngeal squamous carcinoma. | a significant proportion of oropharyngeal squamous cell carcinomas (oscc) are associated with the human papilloma virus (hpv), particularly hpv16. the optimal method for hpv determination on archival materials however, remains unclear. we compared a quantitative real-time polymerase chain reaction (qrt-pcr) assay for hpv16 mrna to a dna in situ hybridization (ish) method, and evaluated their significance for overall (os) and disease-free (dfs) survival. | 2009 | 19884544 |
| oral sexual behaviors and the prevalence of oral human papillomavirus infection: oropharyngeal cancer, "safer sex," and human immunodeficiency virus infection. | 2009 | 19883243 | |
| prevalence and type distribution of human papillomavirus infection in women from datong, china. | this survey of 931 cervical specimens in women from datong, china indicates that the overall human papillomavirus (hpv) prevalence was 18.6%, and the most prevalent high-risk hpv types were 16, 58, 18, 52 and 33. this study demonstrates the epidemiology of hpv infection in datong and the potential impact of vaccination in this region. | 2010 | 19883160 |
| viral entry mechanisms: human papillomavirus and a long journey from extracellular matrix to the nucleus. | papillomaviruses are epitheliotropic non-enveloped double-stranded dna viruses, whose replication is strictly dependent on the terminally differentiating tissue of the epidermis. they induce self-limiting benign tumors of skin and mucosa, which may progress to malignancy (e.g. cervical carcinoma). prior to entry into basal cells, virions attach to heparan sulfate moieties of the basement membrane. this triggers conformational changes, which affect both capsid proteins, l1 and l2, and such change ... | 2009 | 19878308 |
| all 4 di-leucine motifs in the first hydrophobic domain of the e5 oncoprotein of human papillomavirus type 16 are essential for surface mhc class i downregulation activity and e5 endomembrane localization. | the e5 oncoprotein of human papillomavirus type 16 downregulates surface mhc class i and interacts with the heavy chain of the mhc complex via the first hydrophobic domain, believed to form the first helical transmembrane region (tm1) of e5. tm1 contains 4 equally spaced di-leucine (ll1-ll4) motifs. di-leucine motifs have been implicated in protein-protein interactions and as localization signals. to see if any of the 4 di-leucine motifs of tm1 are involved in mhc downregulation by e5, we mutate ... | 2010 | 19876920 |
| the prevalence of human papillomavirus type 58 in chinese patients with cervical carcinoma and its influence on survival. | to assess the prevalence of human papillomavirus (hpv) type-specific infections and its influence on prognosis and survival rate of cervical cancer patients treated with radiotherapy alone or in combination with chemotherapy or hyperthermotherapy or both. | 2009 | 19875274 |
| diindolylmethane inhibits cervical dysplasia, alters estrogen metabolism, and enhances immune response in the k14-hpv16 transgenic mouse model. | this study was designed to establish whether 3,3'-diindolylmethane (dim) can inhibit cervical lesions, alter estrogen metabolism in favor of c-2 hydroxylation, and enhance immune function in the k14-hpv16 transgenic mouse model. mice were bred, genotyped, implanted with e(2) pellets (0.25 mg/90-day release) under anesthesia, and divided into groups. wild-type and transgenic mice were given either ain76a diet alone or with 2,000 ppm dim for 12 weeks. blood and reproductive tracts were obtained. b ... | 2009 | 19861518 |
| human papillomavirus knowledge and awareness among undergraduates in healthcare training in new zealand. | to describe knowledge of hpv and its transmission, knowledge of the hpv vaccine, and awareness of free hpv vaccine for 12-18 year old new zealand females; and to assess whether there are significant age and gender differences in hpv-related knowledge. | 2009 | 19859090 |
| [head and neck squamous cell cancer]. | head and neck squamous cell carcinoma (hnscc) is relatively common and is strongly related to smoking and alcohol consumption but infection by human papillomavirus has also emerged as a risk factor for hnscc. the treatment of these tumors is complicated and patients are best served by a multidisciplinary team. the therapy now commonly involves a multidisciplinary approach including surgery, radiation treatment and chemotherapy. lower stage disease carries a relatively good prognosis. the treatme ... | 2009 | 19858546 |
| signature sequence validation of human papillomavirus type 16 (hpv-16) in clinical specimens. | persistent infection indicated by detection of human papillomavirus 16 (hpv-16) on repeat testing over a period of time poses the greatest cervical cancer risk. however, variants of hpv-16, hpv-31 and hpv-33 may share several short sequence homologies in the hypervariable l1 gene commonly targeted for hpv genotyping. the purpose of this study was to introduce a robust laboratory procedure to validate hpv-16 detected in clinical specimens, using the genbank sequence database as the standard refer ... | 2010 | 19858529 |
| evaluation of quadrivalent hpv 6/11/16/18 vaccine efficacy against cervical and anogenital disease in subjects with serological evidence of prior vaccine type hpv infection. | in the quadrivalent (types 6/11/16/18) hpv vaccine (gardasil/silgard) clinical program, 73% of women aged 16-26 were naïve to all vaccine hpv types. in these women, prophylactic administration of the vaccine was highly effective in preventing hpv 6/11/16/18-related cervical disease. of the remaining women, 15% of had evidence of past infection with one or more vaccine hpv types (seropositive and dna negative) at the time of enrollment. here we present an analysis in this group of women to determ ... | 2009 | 19855170 |
| risk messages about hpv, cervical cancer, and the hpv vaccine gardasil: a content analysis of canadian and u.s. national newspaper articles. | the human papillomavirus vaccine (gardasil) is a significant advancement in women's health. we compared the reporting of fear-inducing messages about human papillomavirus, cervical cancer, and the human papillomavirus vaccine in canadian and u.s. national newspapers between january 2006 and december 2007. significant differences between countries were found in the number of articles containing fear messages about human papillomavirus, cervical cancer, and the human papillomavirus vaccine. educat ... | 2009 | 19851946 |
| high-risk human papilloma virus infection, tumor pathophenotypes, and brca1/2 and tp53 status in juvenile breast cancer. | juvenile breast cancer is rare and poorly known. we studied a series of five breast cancer patients diagnosed within 25 years of age that included two adolescents, 12- and 15-years-old, and 3 young women, 21-, 21-, and 25-years-old, respectively. all cases were scanned for germline mutations along the entire brca1/2 coding sequences and tp53 exons 4-10, using protein truncation test, denaturing high performance liquid chromatography and direct sequencing. paraffin-embedded primary tumors (availa ... | 2010 | 19851859 |
| human papillomavirus types in invasive cervical cancer specimens from turkey. | the main aim of the study is to describe the human papillomavirus (hpv) type-specific distribution in invasive cervical cancer (icc) specimens from turkey. paraffin-embedded icc specimens were identified from the histopathologic archives of the hacettepe university medical school in turkey. hpv detection was carried out through amplification of hpv dna by a spf-10 broad-spectrum primer polymerase chain reaction and subsequently followed by dna enzyme immunoassay and genotyping by lipa25 (version ... | 2009 | 19851201 |
| differential binding patterns to host cells associated with particles of several human alphapapillomavirus types. | the focus of this research was to compare the binding profiles of human papillomavirus (hpv) 11, 16, 18 and 45 virus-like particles (vlps) to hacat cells and to the extracellular matrix (ecm) secreted by these cells. all four hpv types tested bind to a component(s) of the ecm. hpv11 vlp binding is blocked when the ecm is pretreated with an anti-laminin 5 (ln5) polyclonal antibody. a series of treatments utilizing heparins and heparinase revealed that hpv18 vlps are dependent on heparan sulfates ... | 2010 | 19846678 |
| abrogation of the brd4-positive transcription elongation factor b complex by papillomavirus e2 protein contributes to viral oncogene repression. | the cellular bromodomain protein brd4 is a major interacting partner of the papillomavirus (pv) e2 protein. interaction of e2 with brd4 contributes to viral episome maintenance. the e2-brd4 interaction also plays an important role in repressing viral oncogene expression from the integrated viral genome in human pv (hpv)-positive cancer cells. however, the underlying mechanism is not clearly understood. in host cells, brd4 recruits positive transcription elongation factor b (p-tefb) to stimulate ... | 2010 | 19846528 |
| evaluation of an elisa for p16ink4a as a screening test for cervical cancer. | the low sensitivity of cytology and low specificity of human papillomavirus testing prompts searching for more accurate cervical cancer screening strategies. our goal was to evaluate an elisa-based test for p16(ink4a). | 2009 | 19843667 |
| cost-effectiveness of human papillomavirus vaccination and cervical cancer screening in women older than 30 years in the united states. | women older than 30 years are the main beneficiaries of improved cervical cancer screening with human papillomavirus (hpv) dna testing. the role of vaccination against hpv types 16 and 18, which is recommended routinely for preadolescent girls, is unclear in this age group. | 2009 | 19841455 |
| resolution of recurrent conjunctival papilloma after topical and intralesional interferon alpha2b with partial excision in a child. | the human papilloma virus (hpv) is a double-stranded dna virus that infects the epithelium of skin and mucosa. simple treatment of conjunctival papilloma is associated with recurrences, and while most medical therapy has met with limited success, interferon alpha 2b (ifn alpha2b) may be effective. in this report, we describe a 7-year-old child with severe, recurrent conjunctival papilloma who had complete regression of the papilloma after topical and intralesional ifn alpha2b with partial excisi ... | 2009 | 19840738 |
| the biological properties of e6 and e7 oncoproteins from human papillomaviruses. | more than 100 different human papillomavirus (hpv) types have been isolated so far, and they can be sub-grouped in cutaneous or mucosal according to their ability to infect the skin or the mucosa of the genital or upper-respiratory tracts. a sub-group of human mucosal hpvs, referred to as high-risk hpv types, is responsible for approximately 5% of all human cancers, which represents one-third of all the tumours induced by viruses. epidemiological and biological studies have shown that hpv16 is t ... | 2010 | 19838783 |
| an experimental investigation of the emotional and motivational impact of hpv information in adolescents. | we examined psychologic responses to information about human papillomavirus (hpv) in young women within the age range of the uk's hpv vaccination "catch-up" program (13-16 years). respondents absorbed hpv information without becoming worried, were receptive to cervical screening and vaccination, and these attitudes were enhanced by presentation of relevant information. | 2009 | 19837362 |
| parental response to human papillomavirus vaccine availability: uptake and intentions. | this study examined parental responses to the quadrivalent human papillomavirus (hpv) vaccine approximately 2 years post-licensure. correlates of vaccine uptake included daughter age, physician recommendation, and parental knowledge, beliefs, and attitudes. correlates of vaccination intentions were consistent with previous research. findings can inform future efforts aimed at promoting hpv vaccination. | 2009 | 19837361 |
| knowledge and early adoption of the hpv vaccine among girls and young women: results of a national survey. | in 2006, universal human papillomavirus (hpv) vaccination of females ages 9 to 26 years became a formal recommendation, yet little is known about knowledge and adoption of this vaccine. | 2009 | 19837351 |
| appropriate human papillomavirus vaccination strategies. | 2009 | 19837249 | |
| direct visual detection of dna based on the light scattering of silica nanoparticles on a human papillomavirus dna chip. | a detection system for a human papillomavirus (hpv) dna chip based on the light scattering of aggregated silica nanoparticle probes is presented. in the assay, a target hpv dna is sandwiched between the capture dna immobilized on the chip and the probe dna immobilized on the plain silica nanoparticle. the spot where the sandwich reaction occurs appears bright white and is readily distinguishable to the naked eye. scanning electron microscopy images clearly show the aggregation of the silica nano ... | 2009 | 19836580 |
| characterization of papillomavirus e1 helicase mutants defective for interaction with the sumo-conjugating enzyme ubc9. | the e1 helicase from bpv and hpv16 interacts with ubc9 to facilitate viral genome replication. we report that hpv11 e1 also interacts with ubc9 in vitro and in the yeast two-hybrid system. residues in e1 involved in oligomerization (353-435) were sufficient for binding to ubc9 in vitro, but the origin-binding and atpase domains were additionally required in yeast. nuclear accumulation of bpv e1 was shown previously to depend on its interaction with ubc9 and sumoylation on lysine 514. in contrast ... | 2009 | 19836047 |
| cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by e2. | this study systematically examined the viral long control region (lcr) activities and their responses to e2 for human papillomavirus (hpv) types 11, 16, and 18 as well as bovine papillomavirus 1 (bpv1) in a number of different cell types, including human cervical cancer cell lines, human oral keratinocytes, bj fibroblasts, as well as cv1 cells. the study revealed cell- and virus-type specific differences among the individual lcrs and their regulation by e2. in addition, the integration of the lc ... | 2009 | 19836046 |
| [expression, purification and immunogenicity analysis of hpv type 18 virus-like particles from escherichia coli]. | here, we presented a method to bacterially express the major structural protein l1 of human papillomavirus type 18 (hpv18) as soluble form. we found that the purified l1 could self-assemble to virus-like particles (vlps). further, we investigated the immunogenicity and the induced level of neutralizing antibody using these vlps. first, the genome of hpv18 was cloned from a patient in xiamen. it was used as template for pcr amplification of hpv18 l1 gene. the resultant dna fragment was inserted i ... | 2009 | 19835152 |
| bacterial vaginosis: a cause of infertility? | bacterial vaginosis (bv) is a common disorder of the genital tract in women characterized by an alteration of the normal acidic lactobacilli-predominant vaginal ecosystem to a vaginal environment dominated by gardnerella vaginalis, mycoplasma species and anaerobes, with an increase in ph. the present study evaluated whether bv is associated with reproductive complications in women. bv was screened with a gram stain of vaginal smear and interpretation was done using the nugent score. wet mount an ... | 2009 | 19833694 |
| immortalization of ameloblastoma cells via reactivation of telomerase function: phenotypic and molecular characteristics. | ameloblastoma (am) is recognized as a benign tumour but locally invasive with a high risk of recurrence. in vitro model systems for studying am are limited due to the fact that am cells grow poorly and begin to senesce early. japanese researchers have reported the construction of an am cell line, am-1, by exposing cells to human papillomavirus 16 (hpv16) but retaining the potential of transformation. in this study, we used a retroviral infection method to over-express the human telomerase revers ... | 2009 | 19833545 |
| prevalence of human papillomavirus 16 and 18 neutralizing antibodies in prenatal women in british columbia. | human papillomavirus (hpv) type 16 and 18 neutralizing antibody (nab) titers were measured in 1,020 prenatal women in british columbia aged 15 to 39. hpv 16 and 18 nabs were detected in 183/1,020 (17.9%) and 97/1,020 (9.5%), respectively, and 39 (3.8%) had nabs to both types. titers were similar across age strata. | 2009 | 19828766 |
| clinical performance of human papillomavirus e6 and e7 mrna testing for high-grade lesions of the cervix. | infection with high-risk (hr) human papillomavirus (hpv) is the major cause of cervical cancer. however, relatively few infections progress to malignant disease. progression to malignancy requires the overexpression of the e6 and e7 genes in the integrated hpv genome. it follows that the e6 and e7 transcripts could be useful markers of disease progression. the study presented here tests this possibility, using data from colposcopy and from cytological and histological tests to compare rna assays ... | 2009 | 19828739 |
| human papillomavirus-16 e7 interacts with glutathione s-transferase p1 and enhances its role in cell survival. | human papillomavirus (hpv)-16 is a paradigm for "high-risk" hpvs, the causative agents of virtually all cervical carcinomas. hpv e6 and e7 viral genes are usually expressed in these tumors, suggesting key roles for their gene products, the e6 and e7 oncoproteins, in inducing malignant transformation. | 2009 | 19826491 |
| outcomes from a mass media campaign to promote cervical screening in nsw, australia. | despite the decline in the incidence of cervical cancer in australia as a result of population screening, a substantial proportion of women in nsw screen less regularly than the recommended two-yearly interval or do not screen. with higher rates of cervical cancer in unscreened and underscreened women, and despite the introduction of the human papillomavirus vaccine, there remains a need to continue to remind women to screen. the mass media has been shown to be effective at improving participati ... | 2010 | 19822553 |
| anal condyloma acuminatum. | anal condyloma acuminatum is a human papillomavirus (hpv) that affects the mucosa and skin of the anorectum and genitalia. anal condyloma acuminatum is the most commonly diagnosed sexually transmitted disease in the united states. to date, there are more than 100 hpv types, with hpv-6, hpv-10, and hpv-11 predominately found in the anogenital region and causing approximately 90% of genital warts. risk factors for anal condyloma acuminatum include multiple sex partners, early coital age, anal inte ... | 2009 | 19820442 |
| human papillomavirus infection: low-risk and high-risk genotypes in women in catania, sicily. | human papillomavirus (hpv) infection has been strongly and consistently associated with cervical carcinoma and its cytologic precursors, such as squamous intraepithelial lesions. a cross-sectional survey was conducted with the aim of estimating the prevalence of cervical hpv infection in women attending a service of colposcopy in catania, eastern sicily, italy. | 2009 | 19820375 |
| the nonsynonymous single-nucleotide polymorphisms in codon 31 of p21 gene and the susceptibility to cervical cancer in chinese women. | it was suggested that single-nucleotide polymorphisms in p21 codon 31 seem to be associated with a variety of human malignancies; very few studies have focused on the association between p21 codon 31 polymorphisms and cervical cancer. this study explored whether p21 codon 31 nonsynonymous single-nucleotide polymorphisms might be associated with an increased risk of cervical cancer development among chinese women. | 2009 | 19820361 |
| methylation of the long control region of hpv16 is related to the severity of cervical neoplasia. | oncogenic human papillomavirus (hpv) is the cause of cervical cancer. hypermethylation of the cpg islands located at the long control region (lcr) of the hpv genome may regulate the expression of the major oncogenes e6 and e7, and may relate to cancer progression. the goal of the present study was to investigate the methylation patterns of cpg dinucleotides contained within the lcr of the hpv16 genome in a collection of clinical specimens comprising the full spectrum of cervical carcinogenesis. | 2009 | 19819061 |
| targeting and retention of hpv16 e7 to the endoplasmic reticulum enhances immune tumour protection. | the endoplasmic reticulum (er) is where the major histocompatibility complex (mhc) class i molecules are loaded with epitopes to cause an immune cellular response. most of the protein antigens are degraded in the cytoplasm to amino acids and few epitopes reach the er. antigen targeting of this organelle by calreticulin (crt) fusion avoids this degradation and enhances the immune response. we constructed a recombinant adenovirus to express the e7 antigen with an er-targeting signal peptide (sp) p ... | 2010 | 19818090 |
| induction of human papillomavirus oncogene-specific cd8 t-cell effector responses in the genital mucosa of vaccinated mice. | cervical cancer, the second leading cause of cancer mortality in women worldwide, results from infection with a subset of human papillomaviruses (hpv), hpv-16 being the most prevalent type. the available prophylactic vaccines are an effective strategy to prevent this cancer in the long term. however, they only target 70-80% of all cervical cancers and cannot control existing hpv infections and associated lesions. therapeutic vaccines are thus necessary for women who cannot benefit from prophylac ... | 2010 | 19816937 |
| [expression and functional analysis of crt-e2-egfp fusion protein in b16 cells]. | to detect the expression of the calreticulin and hpv e2 fusion protein in b16, and study the effects on proliferation and apoptosis of b16 cell lines in vivo. | 2009 | 19811736 |
| correlation of cxcl12 expression and foxp3+ cell infiltration with human papillomavirus infection and clinicopathological progression of cervical cancer. | human cervical cancer is an immunogenic tumor with a defined pattern of histopathological and clinical progression. tumor-infiltrating t cells contribute to immune control of this tumor; however, cervical cancer dysregulates this immune response both through its association with human papillomavirus (hpv) infection and by producing cytokines and chemokines. animal tumor models have revealed associations between overproduction of the chemokine stromal cell-derived factor-1 (sdf-1 or cxcl12) and d ... | 2009 | 19808652 |