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retention prediction of low molecular weight anions in ion chromatography based on quantitative structure-retention relationships applied to the linear solvent strength model.quantitative structure-retention relationships (qsrrs) represent a popular technique to predict the retention times of analytes, based on molecular descriptors encoding the chemical structures of the analytes. the linear solvent strength (lss) model relating the retention factor, k to the eluent concentration (log k=a-blog [eluent]), is a well-known and accurate retention model in ion chromatography (ic). in this work, qsrrs for inorganic and small organic anions were used to predict the regress ...201728057331
marine reserve targets to sustain and rebuild unregulated fisheries.overfishing threatens the sustainability of coastal marine biodiversity, especially in tropical developing countries. to counter this problem, about 200 governments worldwide have committed to protecting 10%-20% of national coastal marine areas. however, associated impacts on fisheries productivity are unclear and could weaken the food security of hundreds of millions of people who depend on diverse and largely unregulated fishing activities. here, we present a systematic theoretic analysis of t ...201728056064
learning discriminative bayesian networks from high-dimensional continuous neuroimaging data.due to its causal semantics, bayesian networks (bn) have been widely employed to discover the underlying data relationship in exploratory studies, such as brain research. despite its success in modeling the probability distribution of variables, bn is naturally a generative model, which is not necessarily discriminative. this may cause the ignorance of subtle but critical network changes that are of investigation values across populations. in this paper, we propose to improve the discriminative ...201528055846
lower urinary tract symptoms: prevalence, perceptions, and healthcare-seeking behavior amongst nigerian men.the aim of this study was to determine the prevalence of lower urinary tract symptoms (luts) and the factors influencing the healthcare-seeking behavior of men with luts.201628053950
higher rates of sex evolve during adaptation to more complex environments.a leading hypothesis for the evolutionary maintenance of sexual reproduction proposes that sex is advantageous because it facilitates adaptation. changes in the environment stimulate adaptation but not all changes are equivalent; a change may occur along one or multiple environmental dimensions. in two evolution experiments with the facultatively sexual rotifer brachionus calyciflorus, we test how environmental complexity affects the evolution of sex by adapting replicate populations to various ...201728053226
reasons for chemotherapy refusal or acceptance in older adults with cancer.the majority of americans diagnosed as having cancer are older than 65 years. they are, however, less likely than younger patients to receive chemotherapy. our study aimed to better understand the specific reasons for acceptance or refusal of chemotherapy in older adults with cancer.201728052175
assessment of apoptosis in the native vein used for hemodialysis access.to determine whether apoptosis is more common in previously punctured native veins than in non-punctured native veins among patients who undergo surgical creation of arteriovenous fistula (avf) for dialysis access.201628051278
distribution of streptococcus mutans and streptococcus sobrinus in dental plaque of indian pre-school children using pcr and sb-20m agar medium.dental caries is one of the most common infectious diseases affecting the oral cavity. among the oral bacteria, mutans streptococci have been implicated as major cariogenic bacteria as they can produce high levels of dental caries causing substances such as lactic acid and extracellular polysaccharides.201628050506
refining prognosis for intracerebral hemorrhage by early reassessment.prognostic assessments, which are crucial for decision-making in critical illnesses, have shown unsatisfactory reliability. we compared the accuracy of a widely used prognostic score against a model derived from clinical data obtained 5 days after admission for patients with intracerebral hemorrhage (ich), a condition for which prognostication has proven notoriously challenging and prone to bias.201728049196
efficacy and safety of duloxetine in chinese patients with chronic pain due to osteoarthritis: a randomized, double-blind, placebo-controlled study.we assessed the efficacy and safety of duloxetine (60 mg, once daily), compared with placebo, during a 13-week treatment period in chinese patients with chronic pain due to osteoarthritis (oa).201728043937
similar efficacies of endoscopic ultrasound gallbladder drainage with a lumen-apposing metal stent versus percutaneous transhepatic gallbladder drainage for acute cholecystitis.acute cholecystitis in patients who are not candidates for surgery is often managed with percutaneous transhepatic gallbladder drainage (pt-gbd). endoscopic ultrasound-guided gallbladder drainage (eus-gbd) with a lumen-apposing metal stent (lams) is an effective alternative to pt-gbd. we compared the technical success of eus-gbd versus pt-gbd, and patient outcomes, numbers of adverse events (aes), length of hospital stay, pain scores, and repeat interventions.201728043931
long-term outcome of the retrourethral transobturator male sling after transurethral resection of the prostate.to evaluate long-term outcomes of advance and advancexp male slings in patients with persistent stress urinary incontinence (sui) after transurethral resection of the prostate (turp).201628043113
serum uric acid level in relation to severity of the disease and mortality of critically ill patients.this study was conducted to evaluate the validity of serum uric acid (ua) in prediction of mortality among patients in the emergency department.201728042216
an alternative derivation of the stationary distribution of the multivariate neutral wright-fisher model for low mutation rates with a view to mutation rate estimation from site frequency data.recently, burden and tang (2016) provided an analytical expression for the stationary distribution of the multivariate neutral wright-fisher model with low mutation rates. in this paper we present a simple, alternative derivation that illustrates the approximation. our proof is based on the discrete multivariate boundary mutation model which has three key ingredients. first, the decoupled moran model is used to describe genetic drift. second, low mutation rates are assumed by limiting mutations ...201728041892
optimized tomography methods for plasma emissivity reconstruction at the asdex upgrade tokamak.the soft x-ray (sxr) emission provides valuable insight into processes happening inside of high-temperature plasmas. a standard method for deriving the local emissivity profiles of the plasma from the line-of-sight integrals measured by pinhole cameras is the tomographic inversion. such an inversion is challenging due to its ill-conditioned nature and because the reconstructed profiles depend not only on the quality of the measurements but also on the inversion algorithm used. this paper provide ...201628040918
takotsubo cardiomyopathy associated with miller-fisher syndrome.51-year-old female who presented with progressive paresthesia, numbness of the lower extremities, double vision, and trouble walking. physical exam was remarkable for areflexia, and ptosis. her initial ekg showed nonspecific st segment changes and her troponin t was elevated to 0.41ng/ml which peaked at 0.66ng/ml. echocardiogram showed a depressed left ventricular ejection fraction to 35% with severely hypokinetic anterior wall and left ventricular apex was severely hypokinetic. emg nerve conduc ...201728040387
high frequency of programmed death-ligand 1 expression in emphysematous bullae-associated lung adenocarcinomas.emphysematous bullae (eb) are known to be associated with a high incidence of lung cancer; however, the reason for this has yet to be elucidated. the objective of the present study was to clarify the prevalence of programmed death-ligand-1 (pd-l1) expression in eb-associated lung adenocarcinomas.201728038981
brazilian young dental practitioners' use and acceptance of digital radiographic examinations.the aim of this study was to investigate the use and acceptance of digital radiographic examinations by brazilian dental practitioners in daily practice and to evaluate the advances that have occurred over the past 5 years.201628035301
failure of physiologic transformation of spiral arteries, endothelial and trophoblast cell activation, and acute atherosis in the basal plate of the placenta.failure of physiologic transformation of spiral arteries has been reported in preeclampsia, fetal growth restriction, fetal death, and spontaneous preterm labor with intact or ruptured membranes. spiral arteries with failure of physiologic transformation are prone to develop atherosclerotic-like lesions of atherosis. there are striking parallels between preeclampsia and atherosclerotic disease, and between lesions of atherosis and atherosclerosis. endothelial activation, identified by intercellu ...201728034657
sample size determination for the fluctuation experiment.the luria-delbrück fluctuation experiment protocol is increasingly employed to determine microbial mutation rates in the laboratory. an important question raised at the planning stage is "how many cultures are needed?" for over 70 years sample sizes have been determined either by intuition or by following published examples where sample sizes were chosen intuitively. this paper proposes a practical method for determining the sample size. the proposed method relies on existing algorithms for comp ...201728033535
time preferences and natural resource extraction behavior: an experimental study from artisanal fisheries in zanzibar.natural resource users face a trade-off between present and future consumption. using harmful methods or extracting unsustainably, lowers future consumption. therefore, it is reasonable to posit that people with higher time preferences extract more as compared to people with lower time preferences. the present study combines experimental methods and questionnaire data in order to understand the relationship between individual time preferences and fishers' extraction behavior. we elicit individua ...201628033328
breast cancer metastasis associations with clinicopathological characteristics in mexican women younger than 40 years of agebackground: in mexico, breast cancer (bca) is in first place regarding cancer mortality and has been established as a priority health issue. the incidence of metastasis from bca is very high and presents as the principal mortality factor among women younger than 40 years of age. objective. to determine any associations between clinicopathological characteristics and metastasis in mexican women under 40 years of age. methods: during the 2010–2015 period, a total of 180 female bca cases seen at th ...201628032733
comparison of commercial nanoliquid chromatography columns for fast, targeted mass spectrometry-based proteomics.we compared four commonly used, commercially available reverse phase nanolc columns for identification/determination of wnt/β-catenin-related pathway proteins.201628031966
vitamin d status among long-term survivors of testicular cancer.a correlation between disturbances in hormone levels and the onset of metabolic disorders has been reported in long-term survivors of testicular cancer (tc).we evaluated serum vitamin d levels and other biological parameters in a consecutive series of 61 long-term (≥3 years) unilateral tc survivors with a median a follow-up of 4 years and in a cohort of healthy males. deficient vitamin d levels were observed in 10 (17%) of the 58 long-term unilateral tc survivors but were not reported in healthy ...201728030821
healthy exercise habits are associated with lower risk of burnout and higher quality of life among u.s. medical students.although burnout and low quality of life (qol) are common among medical students, little remains known about personal fitness habits of medical students that may promote well-being.201728030419
clinical value of neutrophil to lymphocyte and platelet to lymphocyte ratio after aneurysmal subarachnoid hemorrhage.inflammation and thrombosis are associated with the pathogenesis of aneurysmal subarachnoid hemorrhage (asah) and neutrophil to lymphocyte ratio (nlr) and platelet to lymphocyte ratio (plr) are emerging as novel inflammatory markers in stroke. we aimed to identify the association of nlr and plr with delayed cerebral ischemia (dci) and 3-month outcome after asah.201728028791
comprehensive two-dimensional gas chromatographic profiling and chemometric interpretation of the volatile profiles of sweat in knit fabrics.human axillary sweat is a poorly explored biofluid within the context of metabolomics when compared to other fluids such as blood and urine. in this paper, we explore the volatile organic compounds emitted from two different types of fabric samples (cotton and polyester) which had been worn repeatedly during exercise by participants. headspace solid-phase microextraction (spme) and comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (gc×gc-tofms) were employed to pr ...201728028595
engineered feature used to enhance gardening at a 3800-year-old site on the pacific northwest coast.humans use a variety of deliberate means to modify biologically rich environs in pursuit of resource stability and predictability. empirical evidence suggests that ancient hunter-gatherer populations engineered ecological niches to enhance the productivity and availability of economically significant resources. an archaeological excavation of a 3800-year-old wetland garden in british columbia, canada, provides the first direct evidence of an engineered feature designed to facilitate wild plant f ...201628028536
detection of cancer stem cells in colorectal cancer: histopathological and immunohistochemical study.growing evidence supports the notion that the onset of tumorigenesis could occur through cancer stem cells (cscs). these tumour cells show low proliferative rates, high self-renewal capacity, propensity to differentiate into active proliferating tumour cells & resistance to chemoradiotherapy thus, possibly causing local recurrences & metastasis formation. cd44 has been used as a marker to isolate cscs from colorectal carcinoma (crc).201628028388
effect of etomidate on pneumonia development in critically ill, nontrauma patients.to determine whether etomidate use before intubation increased development of hospital-acquired pneumonia (hap) in critically ill, nontrauma patients.201628027685
impact of industry collaboration on randomised controlled trials in oncology.industry funders can simply provide money or collaborate in trial design, analysis or reporting of clinical trials. our aim was to assess the impact of industry collaboration on trial methodology and results of randomised controlled trials (rct).201728027518
characterization of the neurological diseases associated with mycoplasma pneumoniae infection and anti-glycolipid antibodies.mycoplasma pneumoniae infection often causes various neurological complications of both the central nervous system (cns) and the peripheral nervous system. we retrospectively investigated the igm and igg antibodies to nine glycolipids [gm1, gm2, gm3, gd1a, gd1b, gd3, gt1b, gq1b, and gal-c (galactocerebroside)] and clinical features in neurological diseases associated with m. pneumoniae infection diagnosed in multiple hospitals throughout japan between september 2010 and march 2012. of the 46 pat ...201728025664
the prevalence and risk factors associated with osteoradionecrosis of the jaw in oral and oropharyngeal cancer patients treated with intensity-modulated radiation therapy (imrt): the memorial sloan kettering cancer center experience.to determine the prevalence and correlation of various risk factors [radiation dose, periodontal status, alcohol and smoking] to the development of osteoradionecrosis (orn).201728024723
using fisher information to track stability in multivariate systems.with the current proliferation of data, the proficient use of statistical and mining techniques offer substantial benefits to capture useful information from any dataset. as numerous approaches make use of information theory concepts, here, we discuss how fisher information (fi) can be applied to sustainability science problems and used in data mining applications by analysing patterns in data. fi was developed as a measure of information content in data, and it has been adapted to assess order ...201628018650
survey evaluating the practice of children's hospitals having pharmacist collaborative drug therapy management protocols.objectives: the purpose of this study is to determine how frequently children's hospitals in the united states are using pharmacist-physician collaborative drug therapy management (cdtm), and to characterize their use in this population. methods: a phone survey was created to collect data regarding the use of pharmacist-physician cdtm at children's hospitals. children's hospitals were called between february 2014 and april 2014. data were collected from either a clinical pharmacist or pharmacy d ...201728018151
spheno-orbital meningiomas: a 16-year surgical experience.to examine the efficacy of spheno-orbital meningioma (som) resection aimed at symptomatic improvement, rather than gross total resection, followed by radiation therapy for recurrence.201728017748
wright-fisher exact solver (wfes): scalable analysis of population genetic models without simulation or diffusion theory.the simplifying assumptions that are used widely in theoretical population genetics may not always be appropriate for empirical population genetics. general computational approaches that do not require the assumptions of classical theory are therefore quite desirable. one such general approach is provided by the theory of absorbing markov chains, which can be used to obtain exact results by directly analyzing population genetic markov models, such as the classic bi-allelic wright-fisher model. a ...201628011785
perspectives of patients and family members regarding psychological support using intensive care diaries: an exploratory mixed methods study.diaries summarizing intensive care are routine practice in some countries, although evidence to support diary use is limited. the purpose of this study was to identify whether distress post-intensive care influences patients' and relatives' choice as to whether they would like to receive a diary and what information delivery method is preferred.201728011420
common femoral artery access on youtube: what practices are being shown and who is delivering the message?novice learners are increasingly turning to youtube as a learning resource for surgical procedures. one example of such a procedure is common femoral artery puncture and sheath placement. practitioners in several specialties perform this procedure to access the arterial system for angiography and intervention. we set forth to compare the techniques demonstrated on youtube by the various specialists, as well as compare each specialty׳s prevalence on this website.201728011261
urine culture guided antibiotic interventions: a pharmacist driven antimicrobial stewardship effort in the ed.antibiotics are overprescribed for abnormal urine tests including asymptomatic bacteriuria (ab), contributing to rising antimicrobial resistance rates. pharmacists reviewed urine cultures daily from emergency department (ed) encounters to assess antibiotic appropriateness. we studied antibiotic prescribing practices and assessed compliance to national guidelines, correlations with urine analysis (ua) components, and opportunities for antimicrobial stewardship in the ed.201728010959
simultaneous ability and difficulty estimation via the linear discriminant function.in this paper, parameter estimation of the dichotomous rasch model (rasch, 1960) using the linear discriminant function (fisher, 1936) is presented. this is accomplished by considering the scored item responses to be distinct groups and using a design matrix that is identical to one used in logistic regression for joint maximum likelihood estimation. the real dataset that was examined was the fraction subtraction dataset from tatsuoka (1984). through simulation parameter estimation accuracy usin ...201728009590
sex ratio elasticity influences the selection of sex ratio strategy.there are three sex ratio strategies (srs) in nature-male-biased sex ratio, female-biased sex ratio and, equal sex ratio. it was r. a. fisher who first explained why most species in nature display a sex ratio of ½. consequent srs theories such as hamilton's local mate competition (lmc) and clark's local resource competition (lrc) separately explained the observed deviations from the seemingly universal 1:1 ratio. however, to the best of our knowledge, there is not yet a unified theory that accou ...201628009000
existence of traveling waves for the generalized f-kpp equation.variation in genotypes may be responsible for differences in dispersal rates, directional biases, and growth rates of individuals. these traits may favor certain genotypes and enhance their spatiotemporal spreading into areas occupied by the less advantageous genotypes. we study how these factors influence the speed of spreading in the case of two competing genotypes under the assumption that spatial variation of the total population is small compared to the spatial variation of the frequencies ...201728008475
flow diversion in ruptured intracranial aneurysms: a meta-analysis.flow diversion is now an established technique to treat unruptured intracranial aneurysms not readily amenable to endovascular coil embolization or open microsurgical occlusion. the role of flow-diverting devices in treating ruptured aneurysms is less clear.201728007770
clinical effectiveness of different polishing systems and self-etch adhesives in class v composite resin restorations: two-year randomized controlled clinical trial.the aim of this randomized controlled clinical trial was to compare the clinical effectiveness of different polishing systems and self-etch adhesives in class v composite resin restorations. a total of 164 noncarious cervical lesions (nccls) from 35 patients were randomly allocated to one of four experimental groups, each of which used a combination of polishing systems and adhesives. the two polishing systems used were sof-lex xt (sof), a multistep abrasive disc, and enhance/pogo (ep), a simpli ...201628002695
parasitoids of the eucalyptus gall wasp leptocybe invasa (hymenoptera: eulophidae) in china.leptocybe invasa fisher & la salle (hymenoptera, eulophidae) is an invasive pest in eucalyptus plantations throughout the world. potential biological control agents for l. invasa were investigated in the fujian, guangdong, hainan, guangxi, jiangxi, and sichuan provinces of china, where eucalyptus spp. have been severely damaged by the eucalyptus gall wasp. three hymenopteran parasitoids of l. invasa were identified: quadrastichus mendeli kim & la salle (eulophidae), aprostocetus causalis la sall ...201628000590
detecting spatial regimes in ecosystems.research on early warning indicators has generally focused on assessing temporal transitions with limited application of these methods to detecting spatial regimes. traditional spatial boundary detection procedures that result in ecoregion maps are typically based on ecological potential (i.e. potential vegetation), and often fail to account for ongoing changes due to stressors such as land use change and climate change and their effects on plant and animal communities. we use fisher information ...201728000431
mixed-valence nickel bis(azamacrocycle) compounds with ghost-leg-type sheets.the fabrication of so-called ghost-leg sheets and their electronic properties is reported. this unique sheet structure is composed of one-dimensional mixed-valence nickel chains, which are linked with one another by bis(azamacrocycle) ligands. they are also topologically unique ni(ii) /ni(iii) mixed-valence complexes, as confirmed by x-ray and optical measurements. moreover, their magnetic susceptibilities indicated two-dimensional antiferromagnetic behavior following the fisher 1d chain model w ...201728000324
topical oral cavity chemoprophylaxis using isotretinoin rinse: a 15-year experience.to determine the utility of isotretinoin oral rinses as a method of chemoprevention for recurrent oral cavity squamous cell carcinoma (scc), carcinoma in situ, and dysplasia.201728000225
what is important for confirming negative margins when resecting mandibular ameloblastomas?the purpose of this study was to assess the utility of intraoperative radiographs and frozen sections in achieving negative margins and preventing recurrence of mandibular ameloblastomas.201727998738
the relationship between polyethylene wear and periprosthetic osteolysis in total hip arthroplasty at 12 years in a randomized controlled trial cohort.polyethylene acetabular components are common in hip arthroplasty. highly cross-linked polyethylene (hxlpe) has lower wear than ultra-high molecular weight polyethylene (uhmwpe). evidence suggests that wear particles induce inflammation causing periprosthetic osteolysis contributing to implant loosening with wear rates of 0.05 mm/y were considered safe. we aimed to compare incidence and volume of periacetabular osteolysis between hxlpe and uhmwpe using computed tomography.201727998657
basalit trial: double-blind placebo-controlled allergen immunotherapy with rbet v 1-fv in birch-related soya allergy.conflicting results exist on the effect of allergen immunotherapy (ait) on pollen-related food allergy. we aimed to investigate the efficacy of one-year ait with the folding variant (fv) of recombinant (r) bet v 1 on birch-related soya allergy.201727998002
prediction of possible biomarkers and novel pathways conferring risk to post-traumatic stress disorder.post-traumatic stress disorder is one of the common mental ailments that is triggered by exposure to traumatic events. till date, the molecular factors conferring risk to the development of ptsd is not well understood. in this study, we have conducted a meta-analysis followed by hierarchical clustering and functional enrichment, to uncover the potential molecular networks and critical genes which play an important role in ptsd. two datasets of expression profiles from peripheral blood mononuclea ...201627997584
outcomes of endoscopic dacryocystorhinostomy in secondary acquired nasolacrimal duct obstruction: a case-control study.secondary acquired nasolacrimal duct obstruction (sando), where the obstruction is caused by a known process, is becoming more commonly treated by endoscopic dacryocystorhinostomy (endodcr). this study evaluates outcomes of endodcr for cases of sando in comparison to endodcr outcomes treating primary acquired nasolacrimal duct obstruction (pando).201627997463
anisotropic magnetic coupling with a two-dimensional characteristic in noncentrosymmetric cr11ge19.in this work, we successfully synthesize the single crystal cr11ge19. the magnetism of the noncentrosymmetric cr11ge19 with itinerant ferromagnetic ground state is thoroughly investigated on the single crystal. based on the variation measurements including the angular rotation, temperature, and magnetic field dependence of magnetization, we find that this material exhibits strong magnetic anisotropy along the c-axis. to clearly reveal the magnetic interactions, the critical behavior is studied u ...201627996053
robot-assisted radical prostatectomy in the setting of previous abdominal surgery: perioperative results, oncological and functional outcomes, and complications in a single surgeon's series.data on safety and efficacy of robot-assisted radical prostatectomy (rarp) after previous abdominal surgery are scarce. hence, we assessed perioperative, oncological and functional outcomes, and complications of rarp in patients with previous abdominal surgery after 1-year minimum follow-up.201627989916
everolimus tdm using thermo fisher qms immunoassay on indiko, beckman dxc, au680, and au5800 analyzers.everolimus (evr), a mtor inhibitor immunosuppressant approved for renal, liver and cardiac transplants. this study established the appropriate tdm performances of the thermo scientific qms evr assay by using the beckman dxc, followed by comparison to the thermo scientific indiko and a previously published lc-ms/ms assay, and beckman au680 and au5800 analyzers.201727988326
association between axl, hippo transducers, and survival outcomes in male breast cancer.male breast cancer (mbc) is an uncommon malignancy. we have previously reported that the expression of the hippo transducers taz/yap and their target ctgf was associated with inferior survival in mbc patients. preclinical evidence demonstrated that axl is a transcriptional target of taz/yap. thus, we herein assessed axl expression to further investigate the significance of active taz/yap-driven transcription in mbc. for this study, 255 mbc samples represented in tissue microarrays were screened ...201727987320
sex differences in mortality and morbidity following repair of intact abdominal aortic aneurysms.medicare studies have shown increased perioperative mortality in women compared with men following endovascular and open abdominal aortic aneurysm (aaa) repair. however, a recent regional study of high-volume centers, adjusting for anatomy but limited in sample size, did not show sex to be predictive of worse outcomes. this study aimed to evaluate sex differences after intact aaa repair in a national clinical registry.201727986477
episiotomy technique and management of anal sphincter tears-a survey of clinical practice and education.to ascertain current techniques of episiotomy used by obstetrics and gynaecology faculty members and residents in an academic department and to determine the current management strategies for third and fourth degree tears.201627986182
evaluation of circulating tumor cells in predicting therapeutic response in small cell lung cancer patients.circulating tumor cells (ctcs) have prognostic significance in patients with metastatic cancer, but their utility in predicting the response to tumor therapy is unknown. this study examined the correlation of ctcs with the therapeutic response in small cell lung cancer (sclc).201627986125
movements of a deep-water fish: establishing marine fisheries management boundaries in coastal arctic waters.management boundaries that define populations or stocks of fish form the basis of fisheries planning. in the arctic, decreasing sea ice extent is driving increasing fisheries development, highlighting the need for ecological data to inform management. in cumberland sound, southwest baffin island, an indigenous community fishery was established in 1987 targeting greenland halibut (reinhardtius hippoglossoides) through the ice. following its development, the cumberland sound management boundary (c ...201727984681
mutation at expanding front of self-replicating colloidal clusters.we construct a scheme for self-replicating square clusters of particles in two spatial dimensions, and validate it with computer simulations in a finite-temperature heat bath. we find that the self-replication reactions propagate through the bath in the form of fisher waves. our model reflects existing colloidal systems, but is simple enough to allow simulation of many generations and thereby the first study of evolutionary dynamics in an artificial system. by introducing spatially localized mut ...201627982625
blood pressure treatment adherence and control after participation in the rehot.lack of adherence to pharmacological treatment is one of the main causes of low control rates in hypertension.201627982269
measuring changes in the optic nerve sheath diameter in patients with idiopathic normal-pressure hydrocephalus: a useful diagnostic supplement to spinal tap tests.cerebrospinal fluid (csf) removal improves clinical symptoms of many patients with idiopathic normal-pressure hydrocephalus (inph). the aim of this study was to investigate the correlation of changes in the optic nerve sheath diameter (onsd) with patient responses to csf removal.201727981690
cardiovascular abnormalities and in-hospital all-cause mortality in patients with spontaneous sub-arachnoid hemorrhage: an observational study.patients with spontaneous sub-arachnoid hemorrhage (sah) might develop various cardiac abnormalities, however; the prognostic implications of these cardiac abnormalities are not well known. this study aimed to detect the cardiac abnormality that correlates best with in-hospital all-cause mortality in patients with sah.201727981491
associated factors with cervical pre-malignant lesions among the married fisher women community at sadras, tamil nadu.to identify the associated factors of cervical pre-malignant lesions among the married fisher women residing in the coastal areas of sadras, tamil nadu.201727981091
a comparison between evacuation from the scene and interhospital transportation using a helicopter for subarachnoid hemorrhage.we investigated the changes in the vital signs and the final outcomes subarachnoid hemorrhage (sah) patients who were evacuated from the scene using the doctor-helicopter (dr. heli) service and those who only underwent interhospital transportation using the doctor-helicopter dr. heli service to investigate safety of this system.201727979421
incidence and predictors of angiographic vasospasm, symptomatic vasospasm and cerebral infarction in chinese patients with aneurysmal subarachnoid hemorrhage.cerebral vasospasm (cvs) is the most common neurological complication after aneurysmal subarachnoid hemorrhage (asah) and associated with poor functional outcome and mortality. reports on incidence and predictors of cvs in chinese patients with asah were scarce. we aimed to estimate the incidence and predictors of angiographic vasospasm (av), symptomatic vasospasm (sv), and cerebral infarction in chinese patients with asah.201627977801
preinvasive and invasive cervical adenocarcinoma: preceding low-risk or negative pap result increases time to diagnosis.the aims of the study were to investigate screening histories of women with adenocarcinoma in situ (ais) and adenocarcinoma (adca) of the cervix and to further evaluate screening for glandular disease.201727977543
therapeutic effects of nurse telephone follow-up for lung cancer patients in turkey.patients with lung cancer can encounter many difficulties as they adjust to the side effects of chemotherapy treatments.201627977427
barriers to reconstructive hand surgery for rheumatoid arthritis in china: a multicenter survey of patients and physicians.china has a similar rheumatoid arthritis (ra) disease burden compared with other countries, yet ra patients rarely receive surgical treatment for hand deformities that limit function and impact appearance. we investigated potential barriers to rheumatoid hand surgery in china.201627975029
an overlapping case of miller fisher syndrome, bickerstaff's encephalitis, and the asman variant of guillain-barre syndrome.a 56-year-old man presented with a 3-day history of progressive tingling of the hands, unsteadiness, and diplopia. he was initially diagnosed clinically with miller fisher syndrome (mfs) but later developed limb weakness consistent with guillain-barre syndrome (gbs) and subsequently reduced consciousness consistent with bickerstaff's brainstem encephalitis (bbe). neurophysiology revealed an axonal motor and sensory neuropathy, in keeping with the acute motor and sensory axonal neuropathy (amsan) ...201627974981
health-related quality of life in older coastal residents after multiple disasters.exposure to multiple disasters, both natural and technological, is associated with extreme stress and long-term consequences for older adults that are not well understood. in this article, we address age differences in health-related quality of life in older disaster survivors exposed to the 2005 hurricanes katrina and rita and the 2010 bp deepwater horizon oil spill and the role played by social engagement in influencing these differences.201727974075
fisher-wright model with deterministic seed bank and selection.seed banks are common characteristics to many plant species, which allow storage of genetic diversity in the soil as dormant seeds for various periods of time. we investigate an above-ground population following a fisher-wright model with selection coupled with a deterministic seed bank assuming the length of the seed bank is kept constant and the number of seeds is large. to assess the combined impact of seed banks and selection on genetic diversity, we derive a general diffusion model. the app ...201727964915
the role of voiding cystourethrography in asymptomatic unilateral isolated ureteropelvic junction obstruction: a retrospective study.the presence of concomitant vesicoureteric reflux (vur) and ureteropelvic junction obstruction (upjo) is uncommon. nevertheless, the reported vur coexisting with asymptomatic unilateral isolated hydronephrosis (auih) requiring pyeloplasty for correction of upjo was of low grade and mostly resolved during conservative follow-up. therefore, vcug may be not indicated in these children except if voiding symptoms, urinary tract infection (uti), dilated ureters, or bladder and ureteric abnormalities a ...201727964829
immunotherapy in the precision medicine era: melanoma and beyond.in a perspective, mack su and david fisher discuss the development of immunotherapies for treatment of melanoma and other cancer types.201627959922
in-depth characterization of the tomato fruit pericarp proteome.since the genome of solanum lycopersicum l. was published in 2012, some studies have explored its proteome although with a limited depth. in this work, we present an extended characterization of the proteome of the tomato pericarp at its ripe red stage. fractionation of tryptic peptides generated from pericarp proteins by off-line high-ph reverse-phase phase chromatography in combination with lc-ms/ms analysis on a fisher scientific q exactive and a sciex triple-tof 6600 resulted in the identifi ...201727957804
anti-gq1b-negative miller fisher syndrome with acute areflexic mydriasis and cholinergic supersensitivity.miller fisher syndrome is a rare variant of guillain-barré syndrome and it is characterised by ophthalmoplegia, ataxia, and areflexia. pupillomotor involvement occurs in approximately half of the patients with the disorder. the authors report a patient with acute areflexic mydriasis, external ophthalmoplegia, areflexia, and ataxia. although the pupils were unreactive to light and near stimuli, administration of 0.1% pilocarpine resulted in marked miosis, suggesting cholinergic supersensitivity. ...201127956933
prevalence and predictive value of bi-rads 3, 4, and 5 lesions detected on breast mri: correlation with study indication.this study aims to determine the prevalence and predictive value of breast imaging reporting and data system (bi-rads) 3, 4, and 5 findings on breast magnetic resonance imaging (mri) and to evaluate the impact of study indication on the predictive value of bi-rads categories.201727955878
percutaneous guided biopsy for diagnosing suspected primary malignant bone tumors in pediatric patients: a safe, accurate, and cost-saving procedure.percutaneous biopsy is the reference diagnostic procedure for adult musculoskeletal tumors. its place in pediatrics is controversial and open biopsy remains recommended.201727942776
prediction of opioid analgesic efficacy by measurement of pupillary unrest.pupillary unrest under ambient light (pual) is the fluctuation in pupil diameter in time around a mean value. pual is augmented by light and diminished by administration of opioids. we hypothesized that, because pupillary unrest is a marker of opioid effect, low levels of pual may be associated with reduced opioid efficacy, as measured by changes in the numerical rating scale (nrs) pain scores of patients in the postanesthesia care unit (pacu).201727941575
trade-offs between data resolution, accuracy, and cost when choosing information to plan reserves for coral reef ecosystems.conservation planners must reconcile trade-offs associated with using biodiversity data of differing qualities to make decisions. coarse habitat classifications are commonly used as surrogates to design marine reserve networks when fine-scale biodiversity data are incomplete or unavailable. although finely-classified habitat maps provide more detail, they may have more misclassification errors, a common problem when remotely-sensed imagery is used. despite these issues, planners rarely consider ...201727940319
the disvis and powerfit web servers: explorative and integrative modeling of biomolecular complexes.structure determination of complex molecular machines requires a combination of an increasing number of experimental methods with highly specialized software geared toward each data source to properly handle the gathered data. recently, we introduced the two software packages powerfit and disvis. these combine high-resolution structures of atomic subunits with density maps from cryo-electron microscopy or distance restraints, typically acquired by chemical cross-linking coupled with mass spectro ...201727939290
guillain barré syndrome is induced in non-obese diabetic (nod) mice following campylobacter jejuni infection and is exacerbated by antibiotics.campylobacter jejuni is a leading cause of bacterial gastroenteritis linked to several serious autoimmune sequelae such as the peripheral neuropathies guillain barré syndrome (gbs) and miller fisher syndrome (mfs). we hypothesized that gbs and mfs can result in nod wild type (wt) mice or their congenic interleukin (il)-10 or b7-2 knockouts secondary to c. jejuni infection. mice were gavaged orally with c. jejuni strains hb93-13 and 260.94 from patients with gbs or cf93-6 from a patient with mfs ...201727939129
a randomized controlled trial of end-tidal carbon dioxide detection of preterm infants in the delivery room.to compare the ability of qualitative versus quantitative methods of end-tidal carbon dioxide (etco2) detection to maintain normocarbia during face mask ventilation (fmv) of preterm infants (<32 weeks) in the delivery room.201727939108
[sox10 mutation is relevant to inner ear malformation in patients with waardenburg syndrome].objective: to determine the relevance between the sox10 mutation and waardenburg syndrome (ws) accompanied with inner ear abnormality by analyzing the inner ear imaging results and molecular and genetic results of the ws patients with the sox10 mutation. methods: this study included 36 ws in patients during 2001 and 2015 in the department of otorhinolaryngology head and neck surgery, chinese peoples's liberation army general hospital. the condition of the inner ear of each patient was assessed b ...201627938609
[effects of neoadjuvant chemoradiotherapy on the rates of sphincter preserving surgery in lower rectal cancer and analysis of their prognostic factors].objectives: to identify independent factors of sphincter preserving surgery, and to evaluated whether preoperative chemoradiotherapy (crt) improves the sphincter preservation rate for lower rectal cancers. methods: a total of 541 consecutive patients who underwent curative surgery for locally advanced rectal cancer (ct3-4nx or ctxn+ ) within 6 cm of the anal verge with or without neoadjuvant crt in department of colorectal surgery, union hospital, fujian medical university between september 2000 ...201627938574
"how readers understand causal and correlational expressions used in news headlines": correction to adams et al. (2016).reports an error in "how readers understand causal and correlational expressions used in news headlines" by rachel c. adams, petroc sumner, solveiga vivian-griffiths, amy barrington, andrew williams, jacky boivin, christopher d. chambers and lewis bott (journal of experimental psychology: applied, advanced online publication, nov 3, 2016, np). in the article, the fourth author was inadvertently omitted from the advance online version. also, the second paragraph of the author note should have inc ...201727936831
comparison of tests of contingency tables.we explore the use of bootstrap for testing independence of two categorical variables. we develop a theoretical justification for bootstrapping a contingency table and provide more accurate inference for small sample sizes. we also study the effect of equalized marginals on tests of independence. the small sample properties of the proposed and existing tests of independence are examined using monte carlo simulations. it is shown that the fisher exact test and the chi-squared test with continuity ...201627936354
causes of mortality in individuals with tuberous sclerosis complex.the causes of death in patients with tuberous sclerosis complex (tsc) have rarely been studied, with only one published account, which was reported from the mayo clinic in 1991. we aimed to investigate mortality in a large cohort of patients with tsc from one of two national referral clinics in the uk.201727935023
evaluating frontier orbital energy and homo/lumo gap with descriptors from density functional reactivity theory.wave function theory (wft) and density functional theory (dft)-the two most popular solutions to electronic structure problems of atoms and molecules-share the same origin, dealing with the same subject yet using distinct methodologies. for example, molecular orbitals are artifacts in wft, whereas in dft, electron density plays the dominant role. one question that needs to be addressed when using these approaches to appreciate properties related to molecular structure and reactivity is if there ...201727933419
effect of template reporting of brain mris for multiple sclerosis on report thoroughness and neurologist-rated quality: results of a prospective quality improvement project.to assess the impact of structured reporting templates on the objective and subjective quality of radiology reports for brain mris in patients with multiple sclerosis (ms).201727932248
abdominoplasty and gluteoplasty after massive weight loss: an all-in-one technique.patients requesting body-contouring surgery after massive weight loss often present with abdominal and lumbar skin excess as well as gluteal ptosis and loss of gluteal projection. in order to restore gluteal projection a circular abdominoplasty in combination with an autologous gluteal augmentation (all-in-one technique) can be performed.201727931170
multiple factors affect socioeconomics and wellbeing of artisanal sea cucumber fishers.small-scale fisheries are important to livelihoods and subsistence seafood consumption of millions of fishers. sea cucumbers are fished worldwide for export to asia, yet few studies have assessed factors affecting socioeconomics and wellbeing among fishers. we interviewed 476 men and women sea cucumber fishers at multiple villages within multiple locations in fiji, kiribati, tonga and new caledonia using structured questionnaires. low rates of subsistence consumption confirmed a primary role of ...201627930649
cramer-rao lower bound evaluation for linear frequency modulation based active radar networks operating in a rice fading environment.this paper investigates the joint target parameter (delay and doppler) estimation performance of linear frequency modulation (lfm)-based radar networks in a rice fading environment. the active radar networks are composed of multiple radar transmitters and multichannel receivers placed on moving platforms. first, the log-likelihood function of the received signal for a rician target is derived, where the received signal scattered off the target comprises of dominant scatterer (ds) component and w ...201627929433
late presentation of ataxia, areflexia, and electrophysiological abnormalities as part of miller fisher syndrome: case report.miller fisher syndrome (mfs) is characterised by the triad of ophthalmoplegia, ataxia, and areflexia. a case with external ophthalmoplegia and absence of ataxia and areflexia until the end of second week is presented. electrophysiological findings became apparent after the third week and showed reduced amplitudes of sensory nerve action potentials and prolonged latencies of f with no evidence of conduction blocks. there was no response to intravenous immunoglobulin, but there was response to cor ...201627928406
early intraocular complications of subarachnoid haemorrhage after aneurysm rupture.the aim of this study was to identify factors predisposing for early intraocular complications of aneurysmal subarachnoid haemorrhage (sah). the authors analysed 96 selected cases of aneurysmal sah. forty patients (42%) demonstrated abnormal fundus findings, including disc swelling (13.5%), retinal haemorrhages (23%), and vitreous haemorrhage (5%). the incidence of intraocular pathologies was significantly higher in patients who lost consciousness at the onset of sah, were admitted with high sco ...201427928299
sagittal alignment two years after selective and nonselective thoracic fusion for lenke 1c adolescent idiopathic scoliosis.matched cohort.201527927559
do ponte osteotomies enhance correction in adolescent idiopathic scoliosis? an analysis of 191 lenke 1a and 1b curves.retrospective review of a prospectively collected multicenter database of patients with adolescent idiopathic scoliosis (ais).201527927535
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