Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| the association between unwanted sexual experiences and early-onset cervical cancer and precancer by age 25: a case-control study. | we examined the association between unwanted sexual experiences and cervical cancer, cervical intraepithelial neoplasia 3, adenocarcinoma in situ, diagnosed ≤25 years of age. | 2016 | 27854558 |
| 2016 | 27854170 | ||
| identifying hispanic mothers' salient beliefs about human papillomavirus vaccine initiation in their adolescent daughters. | guided by the integrative model of behavioral prediction, we identify mothers' salient beliefs regarding their daughters' initiation of the human papillomavirus vaccine series. in all, 34 hispanic mothers responded to elicitation questions. salient beliefs included the following: (1) feeling secure, happy, relieved, concerned, and fear about vaccinating; (2) believing that vaccinating prevents and protects from human papillomavirus but may result in side effects and sexual disinhibition; (3) ide ... | 2016 | 27852885 |
| evaluation of viral load as a triage strategy with primary high-risk human papillomavirus cervical cancer screening. | the aim of the study was to evaluate the human papillomavirus (hpv) viral load combined with cytology as a secondary screening strategy after primary hpv screening. | 2017 | 27851695 |
| malignancies in women with hiv infection. | to review current knowledge of different cancer states affecting women with hiv infection. | 2017 | 27849632 |
| oral squamous papilloma occurring on the palate with review of literature. | squamous papillomas are common lesions occurring on skin, oral and nasal mucosa and male and female genital organs. oral squamous cell papilloma (osp) is a benign proliferation of the stratified squamous epithelium and is generally believed to be caused by human papilloma viruses (hpv). it constitutes around 2.5% of all oral verruco-papillary lesions. we here, report a case of palatal osp occurring in a 55-year-old male. the aetiological, clinical, diagnostic and treatment aspects of osp are dis ... | 2016 | 27849344 |
| is human papilloma virus vaccination effective for oral cancer? | 2016 | 27847730 | |
| adsorption of a synthetic tlr7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: a formulation approach. | for nearly a century, aluminum salts have been the most widely used vaccine adjuvant formulation, and have thus established a history of safety and efficacy. nevertheless, for extremely challenging disease targets such as tuberculosis or hiv, the adjuvant activity of aluminum salts may not be potent enough to achieve protective efficacy. adsorption of tlr ligands to aluminum salts facilitates enhanced adjuvant activity, such as in the human papilloma virus vaccine cervarix®. however, some tlr li ... | 2016 | 27847326 |
| uptake of the human papillomavirus vaccine in kenya: testing the health belief model through pathway modeling on cohort data. | many studies investigate hpv vaccine acceptability, applying health behavior theories to identify determinants; few include real uptake, the final variable of interest. this study investigated the utility of the health belief model (hbm) in predicting hpv vaccine uptake in kenya, focusing on the importance of promotion, probing willingness to vaccinate as precursor of uptake and exploring the added value of personal characteristics. | 2016 | 27846857 |
| evaluation of human papillomavirus detection by abbott m2000 system on samples collected by fta elute™ card in a chinese hiv-1 positive population. | hiv+/aids women have an increased risk of developing into cin and cervical cancer compared to the general population. limited medical resource and the lack of aids relevant knowledge impair the coverage and efficiency of cervical cancer screening. | 2016 | 27846440 |
| human papillomavirus as a cause of anal cancer and the role of screening. | anal cancer is a serious health problem in hiv-positive men who have sex with men, and precursor lesions, anal intraepithelial neoplasia, are well defined. given the similarities with cervical cancer, screening for and treatment of anal intraepithelial neoplasia might prevent anal cancer. screening programmes should meet the wilson and jungner criteria. we used these criteria to evaluate the current body of evidence supporting a screening programme for anal dysplasia. | 2017 | 27845952 |
| effects of numerical information on intention to participate in cervical screening among women offered hpv vaccination: a randomised study. | to investigate the effects of different types of information about benefits and harms of cervical screening on intention to participate in screening among women in the first cohorts offered human papilloma virus (hpv) vaccination. | 2016 | 27845597 |
| o-linked-n-acetylglucosamine transferase is associated with metastatic spread of human papillomavirus e6 and e7 oncoproteins to the lungs of mice. | high-risk human papilloma virus (hpv) 16/18 infections are often found in lung cancer. the cellular mechanisms involved in the metastatic spread of hpv-infected cervical cancer cells remain largely elusive. high o-linked-n-acetylglucosamine (o-glcnac) modification has also been observed in lung cancer. in the present study, we assessed the relationship between o-glcnac transferase (ogt) and hpv 16/18 e6/e7, or c-x-c chemokine receptor type 4 (cxcr4), in hela cells and in lungs of xenografted mic ... | 2017 | 27845045 |
| randomized phase ii study of duligotuzumab (mehd7945a) vs. cetuximab in squamous cell carcinoma of the head and neck (mehgan study). | duligotuzumab, a novel dual-action humanized igg1 antibody that blocks ligand binding to epidermal growth factor receptor (egfr) and human epidermal growth factor receptor 3 (her3), inhibits signaling from all ligand-dependent her dimers, and can elicit antibody-dependent cell-mediated cytotoxicity. high tumor-expression of neuregulin 1 (nrg1), a ligand to her3, may enhance sensitivity to duligotuzumab. | 2016 | 27843803 |
| giant condyloma acuminata in indonesian females with sle under immunosuppressant and steroid therapy. | introduction. immunosuppressant and steroid therapy in systemic lupus erythematosus (sle) increases the risk of human papillomavirus (hpv) infections, one of which is giant condyloma acuminata (gca). to our knowledge, there is no report evaluating the correlation between immunosuppressive and steroid therapy in patients with sle and the prevalence of gca. case report. a 42-year-old female was diagnosed with sle a year ago and has been treated with steroids and immunosuppressive drugs. in the las ... | 2016 | 27843658 |
| invasive cervical cancers in the united states, botswana and kenya: hpv type distribution and health policy implications. | more deaths occur in african women from invasive cervical cancer (icc) than from any other malignancy. icc is caused by infection with oncogenic types of human papillomavirus (hpv). co-infection with the human immunodeficiency virus (hiv) accelerates the natural history of icc, and may influence the hpv type distribution. because hpv vaccines are available, this malignancy is theoretically preventable, but the vaccines are largely type-specific in protection against infection. data on specific h ... | 2016 | 27843487 |
| genotyping for human papillomavirus types 16 and 18 in women with minor cervical lesions: a systematic review and meta-analysis. | high-risk human papillomavirus (hrhpv) testing to triage women with minor cervical lesions generates many referrals. | 2017 | 27842420 |
| health information seeking on the internet: the role of involvement in searching for and assessing online health information. | this study focuses on how young people with differing levels of involvement seek and evaluate information about the human papillomavirus online. the results, which are drawn from an experiment and a self-administered survey, suggest that compared to people with a low level of involvement, people with a high level of involvement engage in more information search activity. the results also indicate that those with a high level of involvement in a given subject place a higher value on a website's m ... | 2016 | 27841742 |
| safety of the human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine in adolescents aged 12-15 years: interim analysis of a large community-randomized controlled trial. | this community-randomized controlled trial was initiated to assess the overall and herd effects of 2 different human papillomavirus (hpv) immunization strategies in over 80,000 girls and boys aged 12-15 y in 33 communities in finland (clinicaltrials.gov nct00534638). overall, 14,838 adolescents received hpv-16/18 vaccine (2,440 boys and 12,398 girls) and 17,338 received hepatitis-b virus (hbv) vaccine (9,221 boys and 8,117 girls). in an interim analysis, vaccine safety was assessed by active mon ... | 2016 | 27841725 |
| recurrent head and neck cancer: united kingdom national multidisciplinary guidelines. | this is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the uk. recurrent cancers present some of the most challenging management issues in head and neck surgical and oncological practice. this is rendered even more complex by the poor evidence base to support management options, the substantial implications that treatments can have on the function and quality of life, and the difficult decision-making considerations for supp ... | 2016 | 27841130 |
| oropharyngeal cancer: united kingdom national multidisciplinary guidelines. | this is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the uk. there has been significant debate in the management of oropharyngeal cancer in the last decade, especially in light of the increased incidence, clarity on the role of the human papilloma virus in this disease and the treatment responsiveness of the human papilloma virus positive cancers. this paper discusses the evidence base pertaining to the management of oroph ... | 2016 | 27841123 |
| aetiology and risk factors for head and neck cancer: united kingdom national multidisciplinary guidelines. | this is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the uk. it discusses the aetiology and risk factors for head and neck cancer and the recommended interventions appropriate for each risk factor. recommendations • recent evidence synthesis from national institute for health and care excellence suggests that the following brief interventions for smoking cessation work should be used: ○ ask smokers how interested they are ... | 2016 | 27841107 |
| improved antiviral activity of a polyamide against high-risk human papillomavirus via n-terminal guanidinium substitution. | we report the synthesis of two novel pyrrole-imidazole polyamides with n-terminal guanidinium or tetramethylguanidinium groups and evaluate their antiviral activity against three cancer-causing human papillomavirus strains. introduction of guanidinium improves antiviral activity when compared to an unsubstituted analog, especially in ic90 values. these substitutions change dna-binding preferences, while binding affinity remains unchanged. | 2016 | 27840672 |
| providers' time spent and tools used when discussing the hpv vaccine with parents of adolescents. | little is known about hpv vaccine communication tools currently used by primary care providers of adolescents, or how such tools impact the quality of hpv vaccine recommendations, which some have defined as using a "presumptive" communication style, continuing to offer vaccines despite resistance, and strongly recommending vaccines at the appropriate ages. we surveyed primary care providers to assess their current use of hpv vaccine communication tools, and how these related to their hpv vaccine ... | 2016 | 27840015 |
| spatial variations in cervical cancer prevention in colombia: geographical differences and associated socio-demographic factors. | we examined spatial variations in the frequencies of women who had not heard of human papillomavirus vaccination (nhrd-vac) and who had not had pap testing (nhd-pap) among colombian administrative divisions (departments), before and after considering differences in socio-demographic factors. following global and local tests for clustering, bayesian poisson hierarchical models identified department factors associated with nhrd-vac and nhd-pap, as well as the extent of the spatially structured and ... | 2016 | 27839583 |
| increasing hpv vaccination and eliminating barriers: recommendations from young men who have sex with men. | there is a disparity in hpv vaccination rates in particular among young men who have sex with men (ymsm) and until very recently there has been a dearth of research examining factors related to hpv vaccination for ymsm. the purpose of this study was to elicit ymsm's beliefs about hpv and the hpv vaccine as well as describe perceived barriers and facilitators of vaccine initiation and completion. | 2016 | 27838067 |
| modulation of the dna damage response during the life cycle of human papillomaviruses. | human papillomavirus (hpv) is the most common sexually transmitted viral infection. infection with certain types of hpv pose a major public health risk as these types are associated with multiple human cancers, including cervical cancer, other anogenital malignancies and an increasing number of head and neck cancers. the hpv life cycle is closely tied to host cell differentiation with late viral events such as structural gene expression and viral genome amplification taking place in the upper la ... | 2017 | 27836727 |
| effects of phone and text message reminders on completion of the human papillomavirus vaccine series. | to assess the effect of phone or text message reminders to parents of adolescents on human papillomavirus (hpv) vaccine series completion in rochester, ny. | 2017 | 27836533 |
| associations between vaginal infections and potential high-risk and high-risk human papillomavirus genotypes in female sex workers in western kenya. | infection with and persistence of high-risk human papillomavirus (hr hpv) are the strongest risk factors for cervical cancer. little is known about the prevalence and role of concurrent sexually transmitted infections (stis) found in hpv-infected female sex workers (fsw) in africa. this study purports to test our a priori hypotheses that stis are associated with genotypes pertaining to the α-group species 9. the objectives were to determine the prevalence of bacterial vaginosis (bv), trichomonas ... | 2016 | 27836494 |
| study-based evaluation of the abbott realtime high risk hpv test in comparison to the hc2 hr hpv test in women aged ≥30 years using residual lbc thinprep specimens. | high-risk human papillomavirus (hr hpv) testing is already part of cervical cancer screening programs in a number of countries. new tests need to be validated not only in clinical studies but also in routine screening settings with regard to their clinical performance. | 2016 | 27835974 |
| association of cytologic grade of anal "pap" smears with viral loads of human papillomavirus types 16, 18, and 52 detected in the same specimens from men who have sex with men. | human papilloma virus (hpv) load has been linked to cellular abnormalities of the uterine cervix, and proposed as predictors of hpv persistence and progression of dysplasia to cervical cancer. however, the association of hpv viral load and anal dysplasia and cancer has not been as thoroughly investigated. | 2016 | 27835758 |
| the association of health seeking behaviors with human papillomavirus vaccination status among high-risk urban youth. | vaccination is the primary strategy to reduce the burden of human papillomavirus (hpv) related diseases in the united states. unvaccinated youth are at risk for hpv infection and associated diseases, and limited research has explored factors associated with hpv vaccination among those who are disadvantaged and at high risk, including lesbian, gay, bisexual, transgender and queer and/or homeless. | 2016 | 27835629 |
| intravaginal practices and prevalence of sexual and reproductive tract infections among women in rural malawi. | many women engage in intravaginal practices (ivp) with a goal of improving genital hygiene and increasing sexual pleasure. intravaginal practices can disrupt the genital mucosa, and some studies have found that ivp increases risk of acquisition of hiv and bacterial vaginosis (bv). limited prior research also suggests significant associations between ivp, herpes simplex virus type 2 (hsv-2), and high-risk types of human papillomavirus (hpv). | 2016 | 27835627 |
| cdc6 expression is induced by hpv16 e6 and e7 oncogenes and represses e-cadherin expression. | cervical cancer is one of the most common cancers in women worldwide, and its development is related to two viral oncoproteins e6 and e7 from high-risk human papillomaviruses. aberrant expression of e-cadherin is associated with epithelial-to-mesenchymal transition (emt), and it is frequently seen in cervical cancer. however, the underlying mechanisms involved in e-cadherin suppression in cervical cancer are not clear. we studied the effects of human papillomavirus 16 (hpv16) e6 and e7 on e-cadh ... | 2016 | 27834356 |
| differentiated exophytic vulvar intraepithelial lesions are genetically distinct from keratinizing squamous cell carcinomas and contain mutations in pik3ca. | human papillomavirus-negative keratinizing vulvar cancers typically harbor tp53 mutations as do their precursors, differentiated vulvar intraepithelial neoplasia. however, atypical verruciform proliferations are also associated with these malignancies and their pathogenesis is poorly understood. this study compared 11 atypical verruciform lesions, including atypical verruciform hyperplasia, vulvar acanthosis with altered differentiation, and verruciform lichen simplex chronicus, with 14 human pa ... | 2017 | 27834349 |
| a physician's reflection on the moral use of human papilloma virus vaccine. | controversies often surround the use of vaccines, particularly among the pediatric population. often, the possible temporal relationship between vaccination and subsequent disease is at the center of the controversy. however, others have questioned the moral status of the human papilloma virus (hpv) vaccine because of some instances of state coercion and also the possibility that the vaccine may promote promiscuity. this article addresses the moral status of the hpv vaccine from the perspective ... | 2016 | 27833202 |
| murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin. | vaccination is the most powerful way to prevent human beings from contracting infectious diseases including viruses. in the case of the human papillomavirus (hpv) vaccine, an unexpectedly novel disease entity, hpv vaccination associated neuro-immunopathetic syndrome (hans), has been reported and remains to be carefully verified. to elucidate the mechanism of hans, we applied a strategy similar to the active experimental autoimmune encephalitis (eae) model - one of the most popular animal models ... | 2016 | 27833142 |
| human polyomavirus and human papillomavirus prevalence and viral load in non-malignant tonsillar tissue and tonsillar carcinoma. | human papillomaviruses (hpvs) are an acknowledged cause of a subset of oropharyngeal cancers, especially of tonsillar cancer. similar to hpv, some human polyomaviruses (hpyvs), such as merkel cell polyomavirus (mcpyv), have an oncogenic potential. recently, several novel hpyvs have been discovered. the aim of our study was to determine viral dna prevalence and viral dna load of 13 different hpyvs in benign and malignant tonsillar tissue and to compare the data with those found for hpv. a total o ... | 2017 | 27832373 |
| [evaluation of the cost-effectiveness of two alternative human papillomavirus vaccines as prophylaxis against uterine cervical cancer]. | to determine the cost-effectiveness of human papillomavirus (hpv) vaccination and cervical lesion screening versus screening alone for the prevention of uterine cervical cancer (ucc). | 2017 | 27831602 |
| oncogenic role of tumor viruses in humans. | viruses are the intracellular pathogens that reproduce only in the living cell and manipulate the cellular machinery to produce more viruses. viral replications can affect cellular genes of the host in multiple cancerous ways. approximately, 20% of all human oncogenesis is caused by cancer-causing viruses known as oncoviruses. viral infection causes chronic inflammation leading to cell death, uncontrollable proliferation, and modulated expression of some of the regulatory proteins. oncogenesis i ... | 2017 | 27830995 |
| awareness and knowledge about hpv and hpv vaccine among romanian women. | cervical cancer is one of the most prevalent gynecological malignancies worldwide. romania has the highest incidence of this type of cancer in europe. a successful prevention strategy has to consider the primary prevention measures (including health education on human papilloma virus (hpv) infection but also vaccination). the aim of this study was to assess the knowledge and attitudes of romanian women about hpv and hpv vaccine. we conducted a cross-sectional study survey of 454 women using an a ... | 2016 | 27830570 |
| how colposcopy misses invasive cervical cancer: a case report from the improve-colpo study. | colposcopy with biopsy is pivotal to cervical cancer prevention programs as it is called to identify the precancerous lesions on patients that screen positive. we present a cervical cancer case from improve-colpo, a postmarketing, multicenter, two-arm observational study on us community colposcopy that collects outcomes with the adjunctive dynamic spectral imaging (dsi) in its prospective arm. a 45-year-old woman was seen for suffering of heavy periods. she had cytology of atypical squamous cell ... | 2016 | 27830099 |
| human papillomavirus type 18 infection in a female renal allograft recipient: a case report. | human papillomavirus type 18 is the second most common cause of cervical cancer and is found in 7 to 20 % of cases of cervical cancer. the oncogenic potential of high-risk human papillomavirus is associated with expression of early proteins e6 and e7. due to long-term immunosuppressive therapy, renal transplant recipients have a higher risk of developing persistent human papillomavirus infection. | 2016 | 27829434 |
| a naturally occurring variant of hpv-16 e7 exerts increased transforming activity through acquisition of an additional phospho-acceptor site. | human papillomavirus e6 and e7 play critical roles in cancer development, although not all isolates of the viral oncoproteins are identical. a common e7 variant encodes an amino acid change at n29s. we show that this change increases the levels of phosphorylation by ckii by creating an additional phospho-acceptor site at s29. this confers increased phospho-dependent interaction with a number of cellular targets, including tata box binding protein (tbp) and prb. a further consequence is an increa ... | 2017 | 27829177 |
| human papillomavirus-associated anal and cervical cancers in hiv-infected individuals: incidence and prevention in the antiretroviral therapy era. | the incidence of human papillomavirus (hpv)-related cancers has increased (anal cancer) or not declined (cervical cancer) since the introduction of antiretroviral therapy (art). this article reviews recent data on incidence and prevention efforts for hpv-related cancers in the art era. | 2017 | 27828801 |
| in vitro expression of hpv16 e7 linked to hmgb1 immunoadjuvant in mammalian cells. | e7 is the major transforming protein of human papillomavirus (hpv) that plays important role in maintaining the proliferative state in hpv-infected cells. furthermore, high mobility group 1 protein (hmgb1) is a highly conserved component of chromatin that can be secreted by macrophages and activated monocytes and thus functions as an inflammation mediator. | 2016 | 27826978 |
| pax1 and sox1 methylation as an initial screening method for cervical cancer: a meta-analysis of individual studies in asians. | epigenetic alterations of gene or dna methylation have been highlighted as promising biomarkers for early cervical cancer screening. herein, we evaluated the diagnostic performance of paired boxed gene 1 (pax1) and sex determining region y-box 1 (sox1) methylation for cervical cancer detection. | 2016 | 27826568 |
| the danish quality database for cervical cancer screening. | to monitor and improve the quality of the danish national cervical cancer screening program, an annual report is published, including nine quality indicators. | 2016 | 27826216 |
| the interaction between human papillomavirus and other viruses. | the etiological role of human papillomavirus (hpv) in anogenital tract and head and neck cancers is well established. however, only a low percentage of hpv-positive women develop cancer, indicating that hpv is necessary but not sufficient in carcinogenesis. several biological and environmental cofactors have been implicated in the development of hpv-associated carcinoma that include immune status, hormonal changes, parity, dietary habits, tobacco usage, and co-infection with other sexually trans ... | 2017 | 27826043 |
| management of women with human papillomavirus persistence: long-term follow-up of a randomized clinical trial. | introduction of human papillomavirus-based screening is ongoing in many countries, given its higher sensitivity and longer-lasting protection compared with cytology-based screening. however, optimal clinical management of human papillomavirus-positive but cytology-negative women is unclear, and additional studies with clinical follow-up are warranted. | 2017 | 27825977 |
| racial/ethnic disparities in cervical cancer screening and outcomes. | invasive cervical cancer disproportionately affects women without sufficient access to care, with higher rates among minority groups in higher-income countries and women in low-resource regions of the world. many elements contribute to racial/ethnic disparities in the cervical cancer continuum - from screening and diagnosis to treatment and outcome. sociodemographic factors, access to healthcare, income and education level, and disease stage at diagnosis are closely linked to such inequities. de ... | 2016 | 27825171 |
| similar risk patterns after cervical screening in two large u.s. populations: implications for clinical guidelines. | to compare the risks of histologic high-grade cervical intraepithelial neoplasia (cin) or worse after different cervical cancer screening test results between two of the largest u.s. clinical practice research data sets. | 2016 | 27824767 |
| prevalence of human papillomavirus in self-collected cervicovaginal swabs in young women in the united states between 2003 and 2012. | to evaluate whether there was a change in prevalence of human papillomavirus (hpv) in the united states correlated with the introduction of hpv vaccines in both vaccinated and unvaccinated women. | 2016 | 27824760 |
| establishment of a national cervical screening programme in ireland, cervicalcheck: the first 6 years. | the national cervical screening programme, cervicalcheck, commenced in ireland in 2008. free cervical smear tests are offered to over 1.2 million women aged 25-60 every 3 (aged 25-44) and 5 (aged 45-60) years. the purpose of this paper is to highlight the achievements and document the experience of the first 6 years of a new cervical screening programme. data were extracted from the programme screening register and colposcopy management systems. sas, version 9.4 was used for statistical analysis ... | 2016 | 27824660 |
| iκb kinase b mediating the downregulation of p53 and p21 by lipopolysaccharide in human papillomavirus 16(+) cervical cancer cells. | cervical cancer is the second most common cancer of woman in the world, and human papillomavirus (hpv) infection plays an important role in the development of most of the cases. iκb kinase β (ikkβ) is a kinase-mediating nuclear factor kappa b (nf-κb) activation by phosphorylating the inhibitor of nf-κb (iκb) and is related by some diseases caused by virus infection. however, there is little known about the correlation between ikkβ and hpv infection in cervical cancer. this study aimed to investi ... | 2016 | 27824003 |
| long-term survival outcomes in patients with surgically treated oropharyngeal cancer and defined human papilloma virus status. | this study investigated long-term survival outcomes in surgically treated oropharyngeal cancer patients with known human papilloma virus status. | 2016 | 27823577 |
| socio-demographic and reproductive determinants of cervical neoplasia in seven sub-sahara african countries. | since most human papilloma virus (hpv) infections regress without any intervention, hpv is a necessary but may not be a solely sufficient cause of cervical intraepithelial neoplasia (cin) and cervical cancer. hence, the influence of cofactors on progression from cervical hpv infection to high-grade cin and invasive cervical cancer has been a subject of intensive research. | 2016 | 27822586 |
| local action with global impact: highly similar infection patterns of human viruses and bacteriophages. | the investigation of host-pathogen interaction interfaces and their constituent factors is crucial for our understanding of an organism's pathogenesis. here, we explored the interactomes of hiv, hepatitis c virus, influenza a virus, human papillomavirus, herpes simplex virus, and vaccinia virus in a human host by analyzing the combined sets of virus targets and human genes that are required for viral infection. we also considered targets and required genes of bacteriophages lambda and t7 infecti ... | 2017 | 27822522 |
| burden of cancers attributable to infectious agents in nigeria: 2012-2014. | infections by certain viruses, bacteria, and parasites have been identified as risk factors for some cancers. in nigeria, like many other developing countries, infections remain a leading cause of morbidity and mortality. while there are data on the incidence of different cancers in nigeria, there has been no study of cancers attributable to infections. this study was carried out to determine the burden of cancers attributable to infections using data from two population-based cancer registries ... | 2016 | 27822455 |
| the danish national penile cancer quality database. | the danish national penile cancer quality database (dapeca-data) aims to improve the quality of cancer care and monitor the diagnosis, staging, and treatment of all incident penile cancer cases in denmark. the aim is to assure referral practice, guideline adherence, and treatment and development of the database in order to enhance research opportunities and increase knowledge and survival outcomes of penile cancer. | 2016 | 27822104 |
| a study of pap smear in hiv-positive females. | hiv-positive females are more likely to have abnormal pap smears than hiv-negative women. these abnormal pap smears are usually associated with low cd4 cell counts and human papilloma virus infection. | 2016 | 27821987 |
| reduction in vaccine-type human papillomavirus prevalence among women in the united states, 2009-2012. | between 2009 and 2012, the proportion of young women in the united states completing the human papillomavirus (hpv) vaccine doubled. to understand how quickly this increased uptake is affecting women in the united states, we evaluated the prevalence of vaccine-type (vt) hpv strains among young women in national data sets from 2009-2010 and 2011-2012. among 18-26-year-old women, the prevalence of vt hpv decreased markedly over a short interval, from 15.4% in 2009-2010 to 8.5% in 2011-2012 (preval ... | 2016 | 27821406 |
| prevalence and distribution of cervical high-risk human papillomavirus and cytological abnormalities in women living with hiv in denmark - the shade. | women living with hiv (wlwh) are at increased risk of persistent human papillomavirus (hpv) infection, cervical dysplasia and cervical cancer compared with women from the general population (wgp). we assessed the prevalence and distribution of cervical high-risk (hr) hpv infection and cytological abnormalities in wlwh compared with wgp in denmark. predictors of hpv and cytological abnormalities were estimated in wlwh. | 2016 | 27821088 |
| comparison of dna testing strategies in monitoring human papillomavirus infection prevalence through simulation. | hpv dna diagnostic tests for epidemiology monitoring (research purpose) or cervical cancer screening (clinical purpose) have often been considered separately. women with positive linear array (la) polymerase chain reaction (pcr) research test results typically are neither informed nor referred for colposcopy. recently, a sequential testing by using hybrid capture 2 (hc2) hpv clinical test as a triage before genotype by la has been adopted for monitoring hpv infections. also, hc2 has been reporte ... | 2016 | 27821079 |
| hpv genotype analysis for women in shaanxi province of china. | the aim of this study was to examine the subtype distribution of human papilloma virus (hpv) in women in the shaanxi province of china. a dna chip, along with polymerase chain reaction amplification and reverse dot blot technology, was adopted to analyze the hpv genotypes of 22,937 cases of cervical cell specimens. the hpv infection rate was 18.70%, wherein high-risk, low-risk, and high- and low-risk multiple infection rates were 15.75, 2.96 and 1.91%, respectively. high-risk infections accounte ... | 2016 | 27819735 |
| giant perineal condyloma acuminatum (buschke-lowenstein tumour): a case report. | the giant condyloma acuminatum, also known as buschke- lowenstein tumor (blt), is a rare sexually-transmitted disease. moreover, the condyloma acuminatum produced by human papilloma virus (hpv) infection becomes one the most common sexually-transmitted infection which affects the perineal region. under such situations, the first therapeutic option is surgical excision. the objective of this article is to present a case in which the tumor has reached giant dimensions and also to stress the import ... | 2017 | 27819643 |
| human papillomavirus-associated small cell carcinoma/neuroendocrine carcinoma of the oropharynx: a report of two cases. | small cell carcinoma/neuroendocrine carcinoma (scnec) of the oropharynx is uncommon. two cases of scnec in an 81-year-old woman and in a 54-year-old man are presented here. | 2016 | 27818885 |
| down-regulation of microrna-146a is associated with high-risk human papillomavirus infection and epidermal growth factor receptor overexpression in penile squamous cell carcinoma. | dysregulation of host microrna expression has been involved in the development and progression of human papillomavirus (hpv)-related tumors. analysis of mir-146a expression in a series of 59 penile squamous cell carcinomas (psccs) showed that its levels were lower in high-risk hpv-positive than in hpv-negative psccs and inversely correlated with expression of epidermal growth factor receptor (egfr), a known target for mir-146a. analysis of genotype distribution for rs2910164, a common functional ... | 2017 | 27818285 |
| the human papillomavirus e7 oncoprotein as a regulator of transcription. | high-risk human papillomaviruses (hpvs) encode oncoproteins which manipulate gene expression patterns in the host keratinocytes to facilitate viral replication, regulate viral transcription, and promote immune evasion and persistence. in some cases, oncoprotein-induced changes in host cell behavior can cause progression to cancer, but a complete picture of the functions of the viral oncoproteins in the productive hpv life cycle remains elusive. e7 is the hpv-encoded factor most responsible for m ... | 2017 | 27818212 |
| external quality assessment for human papillomavirus 16/18 dna detection and genotyping in shanghai, china. | human papillomavirus (hpv) dna detection and genotyping is now being used for cervical screening by a growing number of laboratories in shanghai, but they may have various levels of proficiency. the objective of this study was to evaluate the performance of clinical laboratories for hpv dna detection and genotyping by an external quality assessment (eqa) program. | 2017 | 27816947 |
| punch biopsy guided by both colposcopy and hr-hpv status is more efficient for identification of immediate high-grade squamous intraepithelial lesion or worse among hpv-infected women with atypical squamous cells of undetermined significance. | to investigate the accuracy of colposcopy for diagnosing high-grade squamous intraepithelial lesion (hsil) or worse (hsil+) in human papillomavirus (hpv)-infected patients with atypical squamous cells of undetermined significance (ascus) cytology, and determine whether genotyping and viral load quantitation can be useful for detecting immediate hsil+ risk in these patients. | 2016 | 27816739 |
| in vitro and in vivo synergistic therapeutic effect of cisplatin with human papillomavirus16 e6/e7 crispr/cas9 on cervical cancer cell line. | human papillomavirus (hpv) type 16 is one of the major etiologic factors of cervical cancer. our study aims to investigate the potentiality of the antiviral clustered regularly interspaced short palindromic repeat (crispr)/crispr-associated cas9 system (crispr/cas9) targeting the e6 and e7 oncogenes of hpv16 as a potential chemosensitizer of cisplatin (cis-diaminedichloroplatinum ii; cddp) for cervical cancer. | 2016 | 27816686 |
| papillomavirus infections in the oral and genital mucosa of asymptomatic women. | human papillomavirus (hpv) has been found in several regions of the body, including the oral cavity. recently, this virus has been associated with oropharyngeal cancer, but little is known about hpv transmission to the oral cavity. we carried out a study to investigate concurrent oral and cervical infections in 76 asymptomatic women attending a healthcare program. demographic and behavior data were obtained through a structured questionnaire. oral and cervical mucosa scrapings were collected and ... | 2017 | 27816418 |
| threshold cost-effectiveness analysis for a therapeutic vaccine against hpv-16/18-positive cervical intraepithelial neoplasia in the netherlands. | in this study, the potential price for a therapeutic vaccine against human papilloma virus (hpv)-16 & 18 (pre)-malignant cervical lesions is examined. a decision tree model was built in the context of the new dutch cervical cancer-screening program and includes a primary test for the presence of hpv. based on data of cervical cancer screening and hpv prevalence in the netherlands, cohorts were created with hpv-16 or 18 positive women with cervical intraepithelial neoplasia (cin) 2 or 3 or cervic ... | 2016 | 27816370 |
| assessment of human papillomavirus e6/e7 oncogene expression as cervical disease biomarker. | the aims of this study were to detect hpv e6/e7 mrna expression in women with high-risk genotypes (hpv-16, -18, -31, -33 and -45) analysing its relationship with tissue pathology and 2) 2-year follow-up of e6/e7 mrna tested group. | 2016 | 27816058 |
| human papillomavirus detection in fine needle aspiration cytology of lymph node metastasis of head and neck squamous cell cancer. | currently, testing on hpv in oropharyngeal squamous cell carcinoma (opscc) is performed on histological material. however, in a certain percentage of the cases who present with lymph node metastases no primary tumor can be identified and only fine needle aspiration cytology (fnac) is available for analysis. | 2016 | 27816020 |
| human papillomavirus prevalence in unvaccinated heterosexual men after a national female vaccination program. | in australia, high uptake of the quadrivalent human papillomavirus (4vhpv) vaccine has led to reductions in the prevalence of human papillomavirus (hpv) genotypes 6, 11, 16, and 18 in women and girls aged ≤25 years. we evaluated the impact of the program impact on hpv prevalence in unvaccinated male subjects. | 2017 | 27815379 |
| interventions to close the divide for women with breast and cervical cancer between low-income and middle-income countries and high-income countries. | breast and cervical cancers are the commonest cancers diagnosed in women living in low-income and middle-income countries (lmics), where opportunities for prevention, early detection, or both, are few. yet several cost-effective interventions could be used to reduce the burden of these two cancers in resource-limited environments. population- wide vaccination against human papillomavirus (hpv) linked to cervical screening, at least once, for adult women has the potential to reduce the incidence ... | 2017 | 27814963 |
| estimating long-term clinical effectiveness and cost-effectiveness of hpv 16/18 vaccine in china. | human papillomavirus (hpv) 16 and 18 are the two most common hpv oncogenic types that can be prevented by vaccination. this study aimed at assessing the cost-effectiveness of 3 doses of the bivalent hpv vaccine in rural and urban settings in china. | 2016 | 27814703 |
| analysis of e2 gene integrity in hpv16 and hpv58 viruses isolated from women with cervical pathology. | integration of human papillomavirus (hpv) dna into human cells accompanied by the disruption of the viral genome has been described as a prerequisite for cancer development. this study aimed to investigate e2 gene integrity of hpv16 and hpv58 viruses isolated from infected women with cervical lesions. forty-two hpv16- and 31 hpv58-positive samples were analysed. e2 integrity was assumed when all fragments covering the e2 gene were amplified with specific polymerase chain reaction primers. overal ... | 2016 | 27812600 |
| molecular evidence of high-risk human papillomavirus infection in colorectal tumours from cuban patients. | the association between colorectal cancer and human papillomavirus (hpv) infection is still unproven. the aim of this study was to investigate the presence of high-risk hpv (hr-hpv) dna in colorectal tissues from cuban patients. a total of 63 colorectal formalin-fixed paraffin-embedded tissues were studied (24 adenocarcinoma, 18 adenoma, and 21 colorectal tissues classified as benign colitis). dna from colorectal samples was analysed by quantitative real-time polymerase chain reaction to detect ... | 2016 | 27812599 |
| cervical cancer incidence in british columbia: predicting effects of changes from pap to human papillomavirus screening and of changes in screening participation. | to estimate the impact of increased participation in screening, and of the proposed change from pap to human papillomavirus screening on the incidence of cervical cancer in british columbia. | 2016 | 27810984 |
| perspectives for therapeutic hpv vaccine development. | human papillomavirus (hpv) infections and associated diseases remain a serious burden worldwide. it is now clear that hpv serves as the etiological factor and biologic carcinogen for hpv-associated lesions and cancers. although preventative hpv vaccines are available, these vaccines do not induce strong therapeutic effects against established hpv infections and lesions. these concerns create a critical need for the development of therapeutic strategies, such as vaccines, to treat these existing ... | 2016 | 27809842 |
| study protocol of the choice trial: a three-armed, randomized, controlled trial of home-based hpv self-sampling for non-participants in an organized cervical cancer screening program. | the effectiveness of cervical cancer screening programs is challenged by suboptimal participation and coverage. offering cervico-vaginal self-sampling for human papillomavirus testing (hpv self-sampling) to non-participants can increase screening participation. however, the effect varies substantially among studies, especially depending on the approach used to offer hpv self-sampling. the present trial evaluates the effect on participation in an organized screening program of a hpv self-sampling ... | 2016 | 27809810 |
| widening gap between cervical cancer screenings safe for some. | extending the cervical cancer screening interval beyond 5 years for women aged 40 or above who test negative for human papilloma virus (hpv) is safe, say researchers. | 2016 | 27808642 |
| subsite variation in survival of oropharyngeal squamous cell carcinomas 2004 to 2011. | to evaluate subsite-specific differences in survival between squamous cell carcinomas of the base of tongue and tonsillar fossa in a modern cohort likely to have been treated with intensity-modulated radiation therapy, chemotherapy for stage iii and iv, and have had a high incidence of human papillomavirus-associated tumors. | 2016 | 27808409 |
| the whole story: a systematic review of economic evaluations of hpv vaccination including non-cervical hpv-associated diseases. | many economic evaluations of hpv vaccination have been published, but most have focused on the prevention of cervical disease as a primary health outcome. the cost-effectiveness of vaccination is likely to be underestimated if not all hpv-associated diseases are taken into account. in this review, we assess the influence of non-cervical hpv-associated diseases on the incremental cost-effectiveness ratio (icer) of preadolescent hpv vaccination. areas covered: we systematically searched the litera ... | 2017 | 27807989 |
| programmed death-ligand 1 expression, microsatellite instability, epstein-barr virus, and human papillomavirus in nasopharyngeal carcinomas of patients from the philippines. | most nasopharyngeal carcinomas (npcs) in a high-incidence population are driven by epstein-barr virus (ebv) infection. ebv-associated malignancies have increased expression of the programmed death-ligand 1 (pd-l1). immunotherapy agents targeting the pd-1/pd-l1 pathway have achieved durable treatment effects in patients with various cancer types including ebv-associated malignancies. in this study, we sought to investigate pd-l1 expression in a cohort of patients with npcs from the philippines. f ... | 2016 | 27807760 |
| lymphoepithelioma-like carcinoma of breast-evaluation for epstein-barr virus-encoded rna, human papillomavirus, and markers of basal cell differentiation. | this is a largest series of 5 cases of lymphoepithelioma-like carcinoma (lec) of the breast attempting to look at the expression of basal cytokeratins (cks), human papillomavirus, and epstein-barr virus-encoded rnas in these tumors. five cases were selected after stringent evaluation of all breast carcinomas showing dense lymphoid infiltration. histologically, all these tumors showed the typical histology except 1 tumor that showed an unusual granulomatous response. all tumors were negative for ... | 2016 | 27806845 |
| erratum to "the effect of human papillomavirus on dna repair in head and neck squamous cell carcinoma" [oral oncol. 61 (2016) 27-30]. | 2016 | 27806837 | |
| functional variants of human papillomavirus type 16 demonstrate host genome integration and transcriptional alterations corresponding to their unique cancer epidemiology. | human papillomaviruses (hpvs) are a worldwide burden as they are a widespread group of tumour viruses in humans. having a tropism for mucosal tissues, high-risk hpvs are detected in nearly all cervical cancers. hpv16 is the most common high-risk type but not all women infected with high-risk hpv develop a malignant tumour. likely relevant, hpv genomes are polymorphic and some hpv16 single nucleotide polymorphisms (snps) are under evolutionary constraint instigating variable oncogenicity and immu ... | 2016 | 27806689 |
| deregulated mirnas in human cervical cancer: functional importance and potential clinical use. | cervical cancer (cc) is one of the most common malignancies affecting women worldwide. while the morbidity and mortality associated with cc are decreasing in western countries, they both remain high in developing countries. unfortunately, many issues about molecular mechanisms of cc are not clear yet. mirnas are a group of small noncoding rnas that could post-transcriptionally modulate the expression of specific genes and participate in the initiation and progression of multiple diseases includi ... | 2017 | 27806630 |
| virtues and weaknesses of dna methylation as a test for cervical cancer prevention. | epigenetics is the study of heritable and non-heritable genetic coding that is additive to information contained within classical dna base pair sequences. differential methylation has a fundamental role in the development and outcome of malignancies, chronic and degenerative diseases and aging. dna methylation can be measured accurately and easily via various molecular methods and has become a key technology for research and healthcare delivery, with immediate roles in the elucidation of disease ... | 2016 | 27806357 |
| systemic matrix metalloproteinase-8 response in chronic tonsillitis. | the development of several life-long diseases, such as coronary heart disease, is affected by low-grade systemic inflammation. data on the potential long-term health effects of chronic tonsillitis are limited. many inflammatory conditions present with enhanced systemic matrix metalloproteinase (mmp)-8 response. in head and neck cancer, high plasma level of tissue inhibitor of metalloproteinase (timp)-1 predicts poor prognosis. we analyzed s-mmp-8 with immunofluorometric assay and s-timp-1 with a ... | 2017 | 27804311 |
| the association of medication use with clearance or persistence of oral hpv infection. | persistent oral human papillomavirus (hpv) infection increases risk for oropharyngeal carcinoma, and people living with hiv have higher rates of oral hpv infection and related cancers. some prescription medications have immunomodulatory effects, but the impact of medication use on oral hpv natural history is unknown. | 2016 | 27804058 |
| two cases of acute disseminated encephalomyelitis following vaccination against human papilloma virus. | we herein present two cases of acute disseminated encephalomyelitis (adem) following vaccination against human papilloma virus (hpv). case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of cervarix. brain magnetic resonance imaging (mri) showed an isolated small, demyelinating lesion in the pontine tegmentum. case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of gardasil. brain mri revealed hyperintense lesion in the pons ... | 2017 | 27803416 |
| acute disseminated encephalomyelitis following immunization with human papillomavirus vaccines. | 2016 | 27803397 | |
| a markov decision process model for cervical cancer screening policies in colombia. | cervical cancer is the second most common cancer in women around the world, and the human papillomavirus (hpv) is universally known as the necessary agent for developing this disease. through early detection of abnormal cells and hpv virus types, cervical cancer incidents can be reduced and disease progression prevented. we propose a finite-horizon markov decision process model to determine the optimal screening policies for cervical cancer prevention. the optimal decision is given in terms of w ... | 2017 | 27803361 |
| the vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next? | the vaginal microbiota plays a significant role in health and disease of the female reproductive tract. next-generation sequencing techniques based upon the analysis of bacterial 16s rrna genes permit in-depth study of vaginal microbial community structure to a level of detail not possible with standard culture-based microbiological techniques. the human papillomavirus (hpv) causes both cervical intraepithelial neoplasia (cin) and cervical cancer. although the virus is highly prevalent, only a s ... | 2016 | 27802830 |
| a brief information-motivation-behavioral skills intervention to promote human papillomavirus vaccination among college-aged women. | human papillomavirus (hpv) is prevalent among college-aged women. although hpv vaccines decrease women's risk for cervical cancer, the vaccination rates remain inadequate. | 2016 | 27799835 |