Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [varicella gastritis under immunosuppression : case report of a woman after lung transplantation due to granulomatosis with polyangiitis]. | a 35-year-old woman who had previously undergone a lung transplantation presented with severe abdominal pain and vomiting. the gastroscopy showed diffuse ulcerative gastric lesions. tests for varicella zoster virus and epstein-barr virus via polymerase chain reactions (pcr) on endoscopically obtained gastric biopsies were found to be positive and confirmed varicella gastritis. intravenous antiviral therapy with acyclovir was administered resulting in a normalization of all clinical symptoms, esp ... | 2017 | 28405696 |
| evaluation of a taqman array card for detection of central nervous system infections. | infections of the central nervous system (cns) are often acute, with significant morbidity and mortality. routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that may be unavailable to a number of patients in sub-saharan africa. we developed a taqman array card (tac) that detects multiple pathogens simultaneously from cerebrospinal fluid. the 21-pathogen cns multiple-pathogen tac (cns-tac) assay includes two parasites (ba ... | 2017 | 28404679 |
| human papillomavirus, epstein-barr virus, and methylation status of p16(ink4a) in penile cancer. | little is known about penile carcinogenesis. the aim of this study was to evaluate the prevalence of hpv and ebv, and the methylation status of p16(ink4a) in penile cancer samples, and to contribute to the understanding of the mechanisms responsible for penile cancer development. hpv dna was detected in 63.6% of 122 cases, with hpv16 being the most prevalent type. ebv dna was detected in 47.7%, with ebv-1 being the most prevalent type. hpv/ebv co-infections were found in 27.3% of the cases. hype ... | 2017 | 28403538 |
| human and epstein-barr virus mirna profiling as predictive biomarkers for endemic burkitt lymphoma. | endemic burkitt lymphoma (ebl) is an aggressive b cell lymphoma and is associated with epstein-barr virus (ebv) and plasmodium falciparum malaria co-infections. central to bl oncogenesis is the over-expression of the myc proto-oncogene which is caused by a translocation of an ig enhancer in approximation to the myc gene. while whole genome/transcriptome sequencing methods have been used to define driver mutations and transcriptional dysregulation, microrna (mirna) dysregulation and differential ... | 2017 | 28400759 |
| oral and cutaneous lymphomas other than mycosis fungoides and sézary syndrome in a mexican cohort: recategorization and evaluation of international geographical disparities. | nonmycosis fungoides/sézary syndrome (non-mf/ss) primary cutaneous lymphomas (pcl) are currently categorized under the 2005-world health organization/european organization for research and treatment of cancer (who-eortc) classification for pcl. these differ in behavior from secondary cutaneous lymphomas (scl) and to lymphomas limited to the oral cavity (primary oral lymphomas [pol]) both categorized under the 2016-who classification for lymphoid neoplasms. | 2017 | 28400635 |
| a histological study of fulminant type 1 diabetes mellitus related to human cytomegalovirus reactivation. | fulminant type 1 diabetes mellitus (t1dm) is thought to be partly caused by virus infection. | 2017 | 28398495 |
| natural killer/t-cell lymphomas in pediatric and adolescent patients. | natural killer/t-cell (nk/t-cell) lymphomas are rare in children and adolescents and consist predominantly of nasal-type extranodal nk/t-cell lymphomas. more than half of pediatric/adolescent patients with nk/t-cell lymphomas present with localized nasal/sinus involvement, but the disease may involve many organs. nk/t-cell lymphoma cells are cytotoxic and associated with necrosis and angioinvasion; they express cd56, cd2, cytoplasmic cd3 epsilon, and to a variable degree cd30. the cells contain ... | 2017 | 28398275 |
| real-time pcr detection of the most common bacteria and viruses causing meningitis. | central nervous system (cns) infections require prompt diagnosis, as the clinical condition progresses rapidly and may lead to severe permanent sequelae or death. the causative agents include viruses, bacteria, fungi, and parasites. in this study, samples with the diagnosis of cns infection based on cerebrospinal fluid (csf) sent to us from other hospitals/labs, were studied by multiplex real-time polymerase chain reaction (pcr) method. the purpose of this study is to demonstrate, retrospectivel ... | 2017 | 28397477 |
| m2-polarized tumour-associated macrophages in stroma correlate with poor prognosis and epstein-barr viral infection in nasopharyngeal carcinoma. | to assess the relationships between cd163 expression, localization of cd163(+) macrophages, clinicopathological features and prognosis of npc. | 2017 | 28395580 |
| [causes and management of pediatric spontaneous tonsillar haemorrhage]. | objective: to analyze the causes and management plan of pediatric spontaneous tonsillar haemorrhage(sth). methods: according to the criteria of sth difined by griffies, patients with sth from december 2013 to january 2016 were included in this retrospective study. results: a total of 11 patients were reviewed. the etiological diagnosis included 3 pediatric epstein-barr virus associated infectious mononucleosis(ebv-im), 3 suspected pediatric ebv-im to 3 acute suppurative tonsillitis, 1 acute vira ... | 2017 | 28395496 |
| b-cell and classical hodgkin lymphomas associated with immunodeficiency: 2015 sh/eahp workshop report-part 2. | the 2015 workshop of the society for hematopathology/european association for haematopathology submitted small and large b-cell lymphomas (bcls), including classical hodgkin lymphoma (chl), in the context of immunodeficiency. | 2017 | 28395108 |
| ebv-positive b-cell proliferations of varied malignant potential: 2015 sh/eahp workshop report-part 1. | the 2015 workshop of the society for hematopathology/european association for haematopathology aimed to review b-cell proliferations of varied malignant potential associated with immunodeficiency. | 2017 | 28395107 |
| t- and nk-cell lymphomas and systemic lymphoproliferative disorders and the immunodeficiency setting: 2015 sh/eahp workshop report-part 4. | the 2015 workshop of the society for hematopathology/european association for haematopathology aimed to review immunodeficiency-related t- and natural killer (nk)-cell lymphoproliferations. | 2017 | 28395105 |
| hhv8/kshv-positive lymphoproliferative disorders and the spectrum of plasmablastic and plasma cell neoplasms: 2015 sh/eahp workshop report-part 3. | the 2015 workshop of the society for hematopathology/european association for haematopathology aimed to review immunodeficiency-related lymphoproliferative disorders with plasmablastic and plasma cell differentiation. | 2017 | 28395104 |
| chronic active epstein-barr virus associated enteritis may develop into a precancerous disease. | 2017 | 28394808 | |
| multivisceral transplantation for abdominal tumors in children: a single center experience and review of the literature. | standard management of intra-abdominal pediatric solid tumors requires complete resection. however, tumors with multiple organ and vascular involvement present a unique surgical challenge. we conducted a retrospective chart review of four patients, aged 2-14 years, undergoing mvt for intra-abdominal tumors with significant involvement of the visceral arteries and/or portomesenteric venous system at our institution. indications for mvt included hepatocellular carcinoma, inflammatory myofibroblast ... | 2017 | 28393434 |
| posttransplantation lymphoproliferative disorder after pediatric solid organ transplantation: experiences of 20 years in a single center. | to evaluate the clinical spectrum of posttransplantation lymphoproliferative disorder (ptld) after solid organ transplantation (sot) in children. | 2017 | 28392824 |
| the transcription factor hobit identifies human cytotoxic cd4(+) t cells. | the t cell lineage is commonly divided into cd4-expressing helper t cells that polarize immune responses through cytokine secretion and cd8-expressing cytotoxic t cells that eliminate infected target cells by virtue of the release of cytotoxic molecules. recently, a population of cd4(+) t cells that conforms to the phenotype of cytotoxic cd8(+) t cells has received increased recognition. these cytotoxic cd4(+) t cells display constitutive expression of granzyme b and perforin at the protein leve ... | 2017 | 28392788 |
| pericardial effusion following hematopoietic cell transplantation in children is associated with increased risk of mortality. | hematopoietic cell transplantation (hct) is curative for many pediatric malignant and non-malignant disorders, but is associated with significant morbidity and mortality, including development of pericardial effusion (pef). we report the results of a retrospective chart review performed to assess the incidence, risk factors and prognostic effect of pef in the pediatric hct patients at lucile packard children's hospital (lpch), stanford university. one hundred and nineteen patients receiving hct ... | 2017 | 28390986 |
| posttransplant lymphoproliferative disorder after clinical islet transplantation: report of the first two cases. | we report the first two cases of posttransplant lymphoproliferative disorder (ptld) in recipients of islet transplants worldwide. first, a 44-year-old recipient of three islet infusions developed ptld 80 months after his initial transplantation, presenting with abdominal pain and diffuse terminal ileum thickening on imaging. he was treated with surgical excision, reduction of immunosuppression, and rituximab. seven months later, he developed central nervous system ptld, presenting with vertigo a ... | 2017 | 28390107 |
| epstein-barr virus antibodies in serum and dna load in saliva are not associated with radiological or clinical disease activity in patients with early multiple sclerosis. | to investigate the association of epstein-barr virus (ebv) nuclear antigen-1 (ebna-1) and viral capsid antigen (vca) immunoglobulin (ig)g antibodies in serum as well as ebv dna load in saliva with radiological and clinical disease activity in patients with clinically isolated syndrome (cis) and early relapsing-remitting ms (rrms). | 2017 | 28388676 |
| conjunctival tumor caused by epstein-barr virus-related infectious mononucleosis: case report and review of literature. | the conjunctival tumor associated with epstein-barr virus related infectious mononucleosis is a rare ocular manifestation. only a few cases have been reported in the literature. we reported this rare condition that presented in a 5-year-old boy. | 2017 | 28388350 |
| host virus and pneumococcus-specific immune responses in high-count monoclonal b-cell lymphocytosis and chronic lymphocytic leukemia: implications for disease progression. | patients diagnosed with chronic lymphocytic leukemia display a high incidence of infections due to an associated immunodeficiency that includes hypogammaglobulinemia. a higher risk of infections has also been recently reported for high-count monoclonal b-cell lymphocytosis, while no information is available in low-count monoclonal b-cell lymphocytosis. here, we evaluated the status of the humoral immune system in patients with chronic lymphocytic leukemia (n=58), as well as in low- (n=71) and hi ... | 2017 | 28385786 |
| oral hairy leukoplakia arising in a patient with hairy cell leukaemia: the first reported case. | oral hairy leukoplakia (ohl) is an oral mucosal lesion that is associated with epstein-barr virus infection. it commonly presents as an asymptomatic, non-removable white patch on the lateral borders of the tongue in individuals who are immunocompromised. historically, ohl was thought to be pathognomonic of hiv infection; however, it is now an established phenomenon in a range of conditions affecting immune competence. hairy cell leukaemia (hcl) is a rare chronic b cell lymphoproliferative diseas ... | 2017 | 28385698 |
| untreated relapsing remitting multiple sclerosis patients show antibody production against latent epstein barr virus (ebv) antigens mainly in the periphery and innate immune il-8 responses preferentially in the cns. | multiple sclerosis (ms) is an inflammatory and neurodegenerative disorder of the central nervous system (cns). reliable biomarkers are urgently needed for its diagnosis and management, and as clues to its pathogenesis, in which ebv is implicated. | 2017 | 28385186 |
| post-transplant lymphoproliferative disease in lung transplantation: a nested case-control study. | post-transplant lymphoproliferative disorder (ptld) may compromise long-term outcome of lung transplant (ltx) recipients. a case-control study was performed, comparing ltx recipients with ptld (n=31) to matched recipients without ptld (controls, n=62). risk factors for ptld and post-transplant outcomes were assessed. ptld prevalence was 3.9%, time to ptld 323 (166-1132) days; and 54.8% had early-onset ptld versus 45.2% late-onset ptld. at ltx, more epstein-barr virus (ebv)-seronegative patients ... | 2017 | 28383790 |
| crystal structure of importin-α bound to the nuclear localization signal of epstein-barr virus ebna-lp protein. | epstein-barr virus ebna-lp protein is a transcriptional coactivator of ebna2. efficient nuclear localization of ebna-lp is essential for cooperation with ebna2. here we report the crystal structure of the nuclear import adaptor importin-α1 bound to the nuclear localization signal (nls) of ebna-lp that shows ebna-lp residues 44-rrvrrr-49 binding to the major nls-binding site at the p0-p5 positions. in contrast to previously characterized classical nlss that invariably have a basic residue [either ... | 2017 | 28383161 |
| magnetic resonance imaging-detected tumor residue after intensity-modulated radiation therapy and its association with post-radiation plasma epstein-barr virus deoxyribonucleic acid in nasopharyngeal carcinoma. | purpose : to evaluate the prognostic value of magnetic resonance imaging (mri)-detected tumor residue after intensity-modulated radiation therapy (imrt) and its association with post-treatment plasma epstein-barr virus deoxyribonucleic acid (ebv dna) in nasopharyngeal carcinoma (npc). methods and materials : a prospective database of patients with histologically-proven npc was used to retrospectively analyze 664 cases. pre- and post-treatment mri scans were independently reviewed by two senior r ... | 2017 | 28382149 |
| epstein-barr virus-associated hemophagocytic lymphohistiocytosis during pregnancy. | an 11-week pregnant, 32-year-old japanese woman who had recovered from infectious mononucleosis visited our center due to fever, anorexia, and bilateral hypochondrial pain. blood tests revealed leukopenia, thrombocytopenia and elevated ferritin. she was diagnosed with hemophagocytic lymphohistiocytosis (hlh). a high viral load of the epstein-barr virus (ebv) was recognized, indicating ebv-hlh. she was treated with a single dose of dexamethasone to protect the fetus. however, the disease was unco ... | 2017 | 28381688 |
| inflammatory cytokine production in chronic active epstein-barr virus infection. | in order to clarify the mechanisms underlying the development of inflammation in chronic active epstein-barr virus infection (cabev), we examined cytokine production using patient samples. eleven patients were analyzed. the serum concentrations of ifn-γ, tnf-α, and il-6 were significantly higher in patients than in healthy donors. the mrnas of these cytokines in peripheral blood mononuclear cells were elevated in patients as compared with healthy donors. the mrna of ifn-γ was significantly highe ... | 2017 | 28381684 |
| transient oral human cytomegalovirus infections indicate inefficient viral spread from very few initially infected cells. | cytomegalovirus (cmv) is acquired by the oral route in children, and primary infection is associated with abundant mucosal replication as well as the establishment of latency in myeloid cells that results in lifelong infection. the efficiency of primary cmv infection in humans following oral exposure, however, is unknown. we consistently detected self-limited, low-level oral cmv shedding events, which we termed transient cmv infections, in a prospective birth cohort of 30 highly exposed cmv-unin ... | 2017 | 28381570 |
| clinicopathological analysis of methotrexate-associated lymphoproliferative disorders: comparison of diffuse large b-cell lymphoma and classical hodgkin lymphoma types. | patients with rheumatoid arthritis often develop methotrexate-associated lymphoproliferative disorders (mtx-lpd) during mtx treatment. mtx-lpd occasionally regresses spontaneously after simply discontinuing mtx treatment. in patients without spontaneous regression, additional chemotherapy is required to avoid disease progression. however, the differences between spontaneous and non-spontaneous regression have yet to be elucidated. to clarify the factors important for spontaneous regression, we a ... | 2017 | 28380678 |
| early disseminated lyme disease causing false positive serology for primary epstein-barr virus infection - report of 2 cases. | false positive serology for lyme disease was reported in patients with acute infectious mononucleosis. here we describe two patients with early-disseminated lyme disease who were misdiagnosed with infectious mononucleosis based on false positive tests for primary epstein-barr virus infection. | 2017 | 28379435 |
| severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with epstein-barr virus. | epstein-barr virus, a member of the herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation for 30-50 days. the liver is involved in 80-90% of patients in a self-limiting transient manner, with jaundice being much more uncommon (5%). from a hematological standpoint it may manifest aplastic anemia, neutropenia, and thrombocytopenia. we report a case of infectious mononucleosis ... | 2017 | 28376627 |
| [epstein-barr virus-positive large b-cell lymphoma arising within atrial myxoma:report of a case]. | 2017 | 28376601 | |
| [clinicopathologic analysis of epstein-barr virus-positive mucocutaneous ulcer]. | 2017 | 28376595 | |
| current state of pcr-based epstein-barr virus dna testing for nasopharyngeal cancer. | clinical studies have shown plasma epstein-barr virus (ebv) dna level to be an independent prognostic biomarker for nasopharyngeal carcinoma (npc). however, the proportion of npc patients whose tumors are associated with ebv vary with geographic location, and there are a variety of assays for plasma ebv. to develop the level of evidence needed to demonstrate the clinical utility of plasma ebv dna detection for npc patients and encourage widespread adoption of this biomarker test in clinical labo ... | 2017 | 28376165 |
| evidence for a mesothelial origin of body cavity effusion lymphomas. | primary effusion lymphoma (pel) is a kaposi's sarcoma herpes virus (kshv)-induced lymphoma that typically arises in body cavities of hiv-infected patients. pel cells are often co-infected with epstein-barr virus (ebv). "pel-like" lymphoma is a kshv-unrelated lymphoma that arises in body cavities of hiv-negative patients. "pel-like" lymphoma is sometimes ebv positive. the derivation of pel/"pel-like" cells is unclear. | 2017 | 28376153 |
| the immune response to epstein barr virus and implications for posttransplant lymphoproliferative disorder. | posttransplant lymphoproliferative disorder (ptld) is a serious complication in organ transplant recipients and is most often associated with the epstein barr virus (ebv). ebv is a common gammaherpes virus with tropism for b lymphocytes and infection in immunocompetent individuals is typically asymptomatic and benign. however, infection in immunocompromised or immunosuppressed individuals can result in malignant b cell lymphoproliferations such as ptld. ebv+ ptld can arise following primary ebv ... | 2017 | 28376031 |
| herpes simplex virus 1 and cytomegalovirus are associated with pemphigus vulgaris but not with pemphigus foliaceus disease. | pemphigus vulgaris (pv) and pemphigus foliaceus (pf) are blistering autoimmune diseases that depend on interaction between genetic and environmental factors. viral infections, like herpes simplex viruses 1 and 2 (hsv1/2), cytomegalovirus (cmv), epstein-barr virus and dengue virus, could trigger or exacerbate pemphigus. igm and igg antibodies against these viruses in serum from pv and pf, their relatives and controls were determined. hsv1/2 expression was evaluated by direct immunofluorescence (d ... | 2017 | 28370424 |
| biased agonism and allosteric modulation of gpr183- a 7tm receptor also known as ebv-induced ebi2. | the g protein-coupled receptor epstein barr virus-induced gene 2 (ebi2, also known as gpr183) is activated by oxysterols and plays a pivotal role for proper b cell migration during immune responses. while the molecular basis of agonist binding has been addressed in several studies, the concept of biased agonism of ebi2 has not been explored. | 2017 | 28369721 |
| epstein-barr virus infection-induced inflammasome activation in human monocytes. | inflammasomes are cytoplasmic sensors that regulate the activity of caspase-1 and the secretion of interleukin-1β (il-1β) or interleukin-18 (il-18) in response to foreign molecules, including viral pathogens. they are considered to be an important link between the innate and adaptive immune responses. however, the mechanism by which inflammasome activation occurs during primary epstein-barr virus (ebv) infection remains unknown. human b lymphocytes and epithelial cells are major targets of ebv, ... | 2017 | 28369146 |
| gene expression analysis of hypersensitivity to mosquito bite, chronic active ebv infection and nk/t-lymphoma/leukemia. | the human herpes virus, epstein-barr virus (ebv), is a known oncogenic virus and plays important roles in life-threatening t/nk-cell lymphoproliferative disorders (t/nk-cell lpd) such as hypersensitivity to mosquito bite (hmb), chronic active ebv infection (caebv), and nk/t-cell lymphoma/leukemia. during the clinical courses of hmb and caebv, patients frequently develop malignant lymphomas and the diseases passively progress sequentially. in the present study, gene expression of cd16((-))cd56((+ ... | 2017 | 28367723 |
| using item response theory to optimize measurement of chronic stress in pregnancy. | utilize rasch analysis to develop an optimized self-reported measure of stress in pregnancy and examine the association with patient demographics and biologic measures of stress. | 2017 | 28364845 |
| monitoring of epstein-barr virus (ebv)/cytomegalovirus (cmv)/varicella-zoster virus (vzv) load in patients receiving tocilizumab for rheumatoid arthritis. | 2017 | 28363825 | |
| prevalence of neurotropic viruses in malignant glioma and their onco-modulatory potential. | the association between infectious agents and tumour aetiology is relevant in about 20% of cases. | 2017 | 28358704 |
| analysis of the variability of epstein-barr virus genes in infectious mononucleosis: investigation of the potential correlation with biochemical parameters of hepatic involvement. | primary epstein-barr virus (ebv) infection is usually asymptomatic, although at times it results in the benign lymphoproliferative disease, infectious mononucleosis (im), during which almost half of patients develop hepatitis. the aims of the present study are to evaluate polymorphisms of ebv genes circulating in im isolates from this geographic region and to investigate the correlation of viral sequence patterns with the available im biochemical parameters. | 2016 | 28356886 |
| haemophagocytic lymphohistiocytosis associated with fulminant hepatitis and multiorgan failure following primary epstein-barr virus and herpes simplex virus type 1 infection. | we present a case of severe fatal hepatitis in a young patient presumably triggered by two ubiquitous viral diseases which occurred in close succession. this case is unusual because of the exceptional chronological sequence of primary epstein-barr virus and herpes simplex virus type 1 infection causing systemic immune dysregulation associated with rapidly developing liver failure and consecutive multiorgan failure. clinical, laboratory and histopathological findings indicated the development of ... | 2017 | 28356254 |
| streptococcus gallolyticus infection in colorectal cancer and association with biological and clinical factors. | there is an unambiguous association of streptococcus gallolyticus infection with colorectal cancer, although there is limited information about epidemiology or interaction between molecular and environmental factors. we performed an original quantitative analysis of s. gallolyticus in unselected colorectal cancer patients (n = 190) and their association with clinical, pathological tumor molecular profiles (microsatellite instability, hypermethylator phenotype and chromosomal instability pathways ... | 2017 | 28355283 |
| mouse model of epstein-barr virus lmp1- and lmp2a-driven germinal center b-cell lymphoproliferative disease. | epstein-barr virus (ebv) is a major cause of immunosuppression-related b-cell lymphomas and hodgkin lymphoma (hl). in these malignancies, ebv latent membrane protein 1 (lmp1) and lmp2a provide infected b cells with surrogate cd40 and b-cell receptor growth and survival signals. to gain insights into their synergistic in vivo roles in germinal center (gc) b cells, from which most ebv-driven lymphomas arise, we generated a mouse model with conditional gc b-cell lmp1 and lmp2a coexpression. lmp1 an ... | 2017 | 28351978 |
| cytoreductive conditioning intensity predicts clonal diversity in ada-scid retroviral gene therapy patients. | retroviral gene therapy has proved efficacious for multiple genetic diseases of the hematopoietic system, but roughly half of clinical gene therapy trial protocols using gammaretroviral vectors have reported leukemias in some of the patients treated. in dramatic contrast, 39 adenosine deaminase-deficient severe combined immunodeficiency (ada-scid) patients have been treated with 4 distinct gammaretroviral vectors without oncogenic consequence. we investigated clonal dynamics and diversity in a c ... | 2017 | 28351939 |
| epstein-barr virus and its association with fascin expression in colorectal cancers in the syrian population: a tissue microarray study. | colorectal cancer (crc) is the third most common malignancy in both men and women worldwide. colorectal carcinogenesis is a complex, multistep process involving environmental and lifestyle features as well as sequential genetic changes in addition to bacterial and viral infections. viral infection has a proven role in the incidence of approximately 20% of human cancers including gastric malignancies. accordingly, epstein-barr virus (ebv) has been recently shown to be present in human gastric can ... | 2017 | 28350509 |
| etiologic association between epstein-barr virus and oral squamous cell carcinoma: a brief evidence-based discussion. | epstein-barr virus (ebv), also known as human herpes virus-4, belongs to the γ-subfamily of herpes viruses.(1) nearly 90 to 95% of the world's adult population is an asymptomatic carrier of ebv.(1-3). | 2017 | 28349901 |
| ebv induces persistent nf-κb activation and contributes to survival of ebv-positive neoplastic t- or nk-cells. | epstein-barr virus (ebv) has been detected in several t- and nk-cell neoplasms such as extranodal nk/t-cell lymphoma nasal type, aggressive nk-cell leukemia, ebv-positive peripheral t-cell lymphoma, systemic ebv-positive t-cell lymphoma of childhood, and chronic active ebv infection (caebv). however, how this virus contributes to lymphomagenesis in t or nk cells remains largely unknown. here, we examined nf-κb activation in ebv-positive t or nk cell lines, snt8, snt15, snt16, snk6, and primary e ... | 2017 | 28346502 |
| epithelioid cell granuloma in the bone marrow secondary to epstein-barr virus infection. | 2017 | 28346186 | |
| correlation between epstein-barr virus infection and disease activity of systemic lupus erythematosus: a cross-sectional study | background: systemic lupus erythematosus (sle) is an autoimmune disease for whose pathogenesis viral infections are important. the epstein-barr virus (ebv) is the main infectious etiological agent. this study aimed to quantitative evaluation of ebv in sle patients. materials and methods: in this cross-sectional study, 40 patients with sle diagnosed based on american college of rheumatology criteria were selected using purposive sampling. all were included in the study after obtaining informed co ... | 2017 | 28345840 |
| frequency of epstein barr virus type 1 among nasopharyngeal carcinomas in iranian patients | background: around 95% of the world’s population are infected with the epstein-barr virus (ebv), which can persist latent in b lymphocytes and epithelial cells life-long. ebv has been linked with lymphoid and epithelial cancers and persistence of ebv infection in lymphoid or epithelial cells may result in virus-associated b-cell tumors or nasopharyngeal carcinomas (npc). this study was conducted to determine the frequency of ebv dna in nasopharyngeal carcinoma tissue of iranian patients. materia ... | 2017 | 28345327 |
| pre-emptive and therapeutic adoptive immunotherapy for nasopharyngeal carcinoma: phenotype and effector function of t cells impact on clinical response. | adoptive t cell therapy has emerged as a powerful strategy to treat human cancers especially haematological malignancies. extension of these therapies to solid cancers remains a significant challenge especially in the context of defining immunological correlates of clinical responses. here we describe results from a clinical study investigating autologous epstein-barr virus (ebv)-specific t cells generated using a novel ade1-lmppoly vector to treat patients with nasopharyngeal carcinoma (npc) ei ... | 2017 | 28344888 |
| 2b4-sap signaling is required for the priming of naive cd8(+) t cells by antigen-expressing b cells and b lymphoma cells. | mutations in sh2d1a gene that encodes sap (slam-associated protein) result in x-linked lymphoproliferative disease (xlp), a rare primary immunodeficiency disease defined by exquisite sensitivity to the b-lymphotropic epstein-barr virus (ebv) and b cell lymphomas. however, the precise mechanism of how the loss of sap function contributes to extreme vulnerability to ebv and the development of b cell lymphomas remains unclear. here, we investigate the hypothesis that sap is critical for cd8(+) t ce ... | 2017 | 28344876 |
| periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (pfapa) syndrome in children. | periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (pfapa) syndrome refers to a group of primary immunodeficiencies, namely autoinflammatory diseases. most pediatricians and otolaryngologists do not suspect pfapa syndrome when treating recurrent pharyngitis (according to ukrainian classification - tonsillitis) and stomatitis. therefore, patients with a given syndrome receive unnecessary treatment (antibiotic therapy or antiviral drugs) and the diagnosis is made late. the aim ... | 2017 | 28343210 |
| clinicopathological analysis of primary central nervous system nk/t-cell lymphoma: rare and localised aggressive tumour among extranasal nk/t-cell tumours. | the central nervous system (cns) is a rare primary site of non-hodgkin lymphoma. although direct invasion of nasal nk/t-cell tumours into cns is occasionally reported, primary cns nk/t-cell lymphoma is extremely rare, and the clinicopathological features of primary cns nk/t-cell lymphoma remain largely unknown. | 2017 | 28342197 |
| elevated serum levels of scd30 and il-6 and detectable il-10 precede classical hodgkin lymphoma diagnosis. | we investigated whether an immune system environment characterized by elevated serum levels of b-cell activation molecules was associated with the subsequent development of classical hodgkin lymphoma (chl). | 2017 | 28341757 |
| epstein barr virus hemophagocytic lymphohistiocytosis related to rituximab use and immunopathogenetic insights. | anti-cd20-based chemo-immunotherapeutic regimens have been suggested to assist in the management of epstein-barr virus (ebv)-induced hemophagocytic lymphohistiocytosis (hlh) and ebv-associated post-transplant lymphoproliferative disorders (ebv-ptld), by reducing ebv viral load and ebv-induced inflammation. herein we report a fatal ebv-related hlh in the context of hodgkin lymphoma (hl)-like richter's transformation of b chronic lymphocytic leukemia (b-cll), two months after rituximab treatment. ... | 2016 | 28340951 |
| stable high-level expression of factor viii in chinese hamster ovary cells in improved elongation factor-1 alpha-based system. | recombinant factor viii (fviii), used for haemophilia a therapy, is one of the most challenging among the therapeutic proteins produced in heterologous expression systems. deletion variant of fviii, in which the entire domain b is replaced by a short linker peptide, was approved for medical use. efficacy and safety of this fviii deletion variant are similar to full-length fviii preparations while the level of production in cho cells is substantially higher. typical levels of productivity for cho ... | 2017 | 28340620 |
| a p110δ-specific inhibitor combined with bortezomib blocks drug resistance properties of ebv-related b cell origin cancer cells via regulation of nf-κb. | epstein-barr virus (ebv) infection is closely related to carcinogenesis of various cancers, and is also associated with the development of drug resistance in cancer stem cells. however, in ebv-positive cancer cells, the mechanistic details of the downstream signaling and the connection of pi3k with the nf-κb pathway for development of drug resistance remain controversial. diffuse large b-cell lymphoma (dlbcl) and multiple myeloma (mm) cells infected by ebv display drug resistance-related protein ... | 2017 | 28339079 |
| hla expression and hla type associations in relation to ebv status in hispanic hodgkin lymphoma patients. | a proportion of classical hodgkin lymphomas harbor the epstein barr virus (ebv). we previously demonstrated that associations between human leukocyte antigen (hla) alleles and susceptibility to ebv+ classical hodgkin lymphoma differ between european and chinese populations. data on hispanic populations is missing. here we examined the association between hla type, tumor cell hla expression and other characteristics in hispanic hodgkin lymphoma patients. hispanic hodgkin lymphoma patients diagnos ... | 2017 | 28334025 |
| epstein-barr virus lytic reactivation activates b cells polyclonally and induces activation-induced cytidine deaminase expression: a mechanism underlying autoimmunity and its contribution to graves' disease. | graves' disease is an autoimmune disease that results in and is the most common cause of hyperthyroidism, and the reactivation of persisting epstein-barr virus (ebv) in b lymphocytes induces the differentiation of host b cells into plasma cells. we previously reported that some ebv-infected b cells had thyrotropin receptor antibodies (trabs) as surface immunoglobulins (igs), and ebv reactivation induced these trab+ebv+ cells to produce trabs. ebv reactivation induces ig production from host b ce ... | 2017 | 28333576 |
| evaluation of lipid profile changes in pediatric patients with acute mononucleosis. | acute epstein-barr virus (ebv) infection could lead to atherogenic lipid profile changes in adults; while there is no evidence about the children with infectious mononucleosis (im). the aim of this study was to evaluate the lipid profile of the children in acute phase of mononucleosis and two months after the recovery. | 2017 | 28332346 |
| a novel recombinant variant of latent membrane protein 1 from epstein barr virus in argentina denotes phylogeographical association. | to study lmp1 variants distribution among children with ebv+ malignant and benign conditions as well as in healthy carriers. | 2017 | 28328987 |
| dacryoadenitis as the initial presentation of a natural killer t-cell lymphoma. | primary orbital natural killer t-cell lymphoma (nktcl) is a rare condition with only a few published cases in the literature. over 1 month, an 81-year-old man developed progressive left periocular inflammation unresponsive to treatment. clinical examination and imaging studies demonstrated a left lacrimal gland enlargement. bilateral anterior uveitis and erythematous nontender cutaneous lesions were also found. biopsies of the skin and lacrimal gland on the back revealed histopathologic and immu ... | 2017 | 28328558 |
| solitary plasmacytoma associated with epstein-barr virus: a clinicopathologic, cytogenetic study and literature review. | solitary plasmacytoma (sp) is an uncommon, indolent tumor of plasma cell neoplasms that presents as a mass lesion in extramedullary sites. evidence of epstein-barr virus (ebv) infection is frequently associated with various lymphatic and hematopoietic malignancies but is relatively rare in sp. moreover, it is essential to distinguish ebv-positive plasmacytoma from plasmablastic lymphoma. in this study, we found 4 ebv-encoded rna (eber)-positive patients among 46 consecutive immunocompetent patie ... | 2017 | 28325354 |
| epstein-barr virus gastritis. | 2017 | 28321083 | |
| epstein-barr virus-associated lymphoproliferative disorder with encephalitis following anti-thymocyte globulin for aplastic anemia resolved with rituximab therapy: a case report and literature review. | epstein-barr virus (ebv)-associated lymphoproliferative disorders (lpds) sometimes occur following anti-thymocyte globulin (atg) administration for allogenic stem cell transplantation but are rare in aplastic anemia (aa) patients. a 55-year-old woman with aa following atg developed refractory fever and was diagnosed with ebv-lpd. she was successfully treated with weekly rituximab monotherapy; however, she developed ebv encephalitis. she was admitted to the intensive care unit and finally recover ... | 2017 | 28321074 |
| case of lymphadenopathy with lytic bone lesions. | plasmablastic lymphoma, a rare highly aggressive non-hodgkin's lymphoma subtype, often associated with hiv infection, is a close differential diagnosis of plasmablastic myeloma. the 2 conditions may be morphologically and immunophenotypically identical. however, differentiating between the 2 conditions is critical for adequate patient management. herein, we describe an unusual case of plasmablastic myeloma with biclonal gammopathy which was initially diagnosed as plasmablastic lymphoma based on ... | 2017 | 28320703 |
| cytomegalovirus, epstein-barr virus and varicella zoster virus infection in the first two years of life: a cohort study in bradford, uk. | cytomegalovirus (cmv), epstein barr virus (ebv) and varicella-zoster virus (vzv) are common herpesviruses frequently acquired in childhood, which establish persistent, latent infection and are likely to impact the developing immune system. little is known about the epidemiology of cmv and ebv infections in contemporary uk paediatric populations, particularly whether age at infection differs by ethnic group. | 2017 | 28320319 |
| [promotion of porphyromonas gingivalis to viral disease]. | chronic periodontitis is one of the most common oral diseases in humans, the main recognized pathogenic bac-terium of which is the porphyromonas gingivalis. various types of viruses have been detected in periodontal disease in situ, and the joint action of viral and bacterial pathogens infection mechanism are complicated. porphyromonas gingivalis has the characteristics resulting from the interaction with a variety of bacterium viruses, which may be the reason for chronic perio-dontitis being a ... | 2016 | 28317365 |
| type ii enteropathy-associated t-cell lymphoma: a rare report from iran. | type ii enteropathy-associated t-cell lymphoma (eatl) is a rare disease that is reported from asia, especially from taiwan. in this paper, we present a patient from iran (arab) with type ii eatl whose disease was not associated with celiac disease or epstein-barr virus (ebv) infection. the patient died due to intestinal perforation during the first chemotherapy. type ii eatl is a gastrointestinal lymphoma with poor prognosis and a high affinity for intestinal perforation. early detection of eatl ... | 2017 | 28316767 |
| airway inflammation and symptoms in children following liver and heart transplantation. | to describe the upper airway endoscopic findings of children with upper airway symptoms after liver transplantation (lt) or heart transplantation (ht). | 2017 | 28316109 |
| the clinical significance of epstein-barr virus dna in peripheral blood mononuclear cells in patients with non-hodgkin lymphoma. | the aim of the study was to determine the clinical significance of ebv dna in the peripheral blood mononuclear cells (pbmcs) from the patients with non-hodgkin lymphoma (nhl). newly diagnosed patients with nhl were enrolled in the study (n = 328), and clinical data retrospectively analyzed. ebv dna was detectable in 34.8% of patients, and the positivity rate was 51.6% for t/nk cell subtype and 24.3% for b cell subtype (p < .001). in diffuse large b cell lymphoma (dlbcl), extranodal nk/t-cell lym ... | 2017 | 28306367 |
| myalgic encephalomyelitis/chronic fatigue syndrome and gulf war illness patients exhibit increased humoral responses to the herpesviruses-encoded dutpase: implications in disease pathophysiology. | myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs) and gulf war illness (gwi) are debilitating diseases with overlapping symptomology and there are currently no validated tests for definitive diagnosis of either syndrome. while there is evidence supporting the premise that some herpesviruses may act as possible triggers of me/cfs, the involvement of herpesviruses in the pathophysiology of gwi has not been studied in spite of a higher prevalence of me/cfs in these patients. we have previ ... | 2017 | 28303641 |
| lymphoproliferative disease after pediatric liver transplant. | posttransplant lymphoproliferative disease is a major complication following solid-organ transplant. we summarize the relation of epstein-barr virus to this complication and discuss its treatment in pediatric patients. | 2017 | 28302005 |
| clinical significance of spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia in ebv-associated and ebv-negative gastric cancer. | spasmolytic polypeptide-expressing metaplasia (spem) and intestinal metaplasia (im) have been recognized as neoplastic precursors in gastric carcinogenesis. we explored the relationship between spem and im in epstein-barr virus-associated (ebvagc) and epstein-barr virus-negative (ebvngc) gastric cancer. 64 ebvagc and 154 ebvngc patients were included. ebv-positivity was identified using eber-1 in situ hybridization. spem was sub-classified into absent, early and advanced spem. acute and chronic ... | 2017 | 28300576 |
| roles of runx in b cell immortalisation. | runx1 and runx3 are the main runx genes expressed in b lymphocytes. both are expressed throughout b-cell development and play key roles at certain key developmental transitions. the tumour-associated epstein-barr virus (ebv) has potent b-cell transforming ability and manipulates runx3 and runx1 transcription through novel mechanisms to control b cell growth. in contrast to resting mature b cells where runx1 expression is high, in ebv-infected cells runx1 levels are low and runx3 levels are high. ... | 2017 | 28299664 |
| unveiling another missing piece in ebv-driven lymphomagenesis: ebv-encoded micrornas expression in eber-negative burkitt lymphoma cases. | epstein-barr virus (ebv) is a gammaherpesvirus linked to a number of lymphoid and epithelial malignancies, including burkitt lymphoma (bl) in which its frequency ranges from 30% in sporadic cases to 100% in the endemic ones. the possible contribution of ebv to bl pathogenesis is largely unknown. it has been suggested that ebv may be associated with all of the cases, including those diagnosed as ebv negative by a mechanism of hit-and-run. early during oncogenesis, viral genes are essential for in ... | 2017 | 28298901 |
| a workflow for in silico design of hil-10 and ebvil-10 inhibitors using well-known miniprotein scaffolds. | the over-expression of immune-suppressors such as il-10 is a crucial landmark in both tumor progression, and latent viral and parasite infection. il-10 is a multifunctional protein. besides its immune-cell suppressive function, it also promotes b-cell tumorigenesis of lymphomas and melanoma. human pathogens like unicellular parasites and viruses that remain latent inside b cells promote the over-expression of hil-10 upon infection, which inhibits cell-mediated immune surveillance, and at the sam ... | 2017 | 28293795 |
| dock 8 deficiency, ebv+ lymphomatoid granulomatosis, and intrafamilial variation in presentation. | dedicator of cytokinesis 8 (dock8) deficiency is an autosomal recessive, combined immunodeficiency within the spectrum of hyper-ige syndromes. epstein-barr virus-positive lymphomatoid granulomatosis (lyg) (ebv + lyg) is a rare diagnosis and a previously unreported presentation of dock8 deficiency. a 10-year-old girl was initially evaluated for mild eczema and recurrent sinopulmonary infections. she had normal immunoglobulins with elevated ige, poor polysaccharide response with low switched memor ... | 2017 | 28293550 |
| treatment of post-transplantation lymphoproliferative disorders after kidney transplant with rituximab and conversion to m-tor inhibitor. | post-transplantation lymphoproliferative disorders are serious complications of organ transplantation which treatment is not yet standardized. | 2016 | 28293043 |
| smarcb1 (ini-1)-deficient sinonasal carcinoma: a series of 39 cases expanding the morphologic and clinicopathologic spectrum of a recently described entity. | to more fully characterize the clinical and pathologic spectrum of a recently described tumor entity of the sinonasal tract characterized by loss of nuclear expression of smarcb1 (ini1), we analyzed 39 smarcb1-deficient sinonasal carcinomas collected from multiple medical centers. the tumors affected 23 males and 16 females with an age range of 19 to 89 years (median, 52). all patients presented with locally advanced disease (t3, n=5; t4, n=27) involving the sinuses (mainly ethmoid) with variabl ... | 2017 | 28291122 |
| the added value of hepatitis e diagnostics in determining causes of hepatitis in routine diagnostic settings in the netherlands. | hepatitis e virus (hev) genotype 3 is endemic in europe and an underdiagnosed and emerging (public) health issue. in recent years commercial enzyme immunoassays (eias) that detect antibodies to hev more adequately, became available. we investigated the added value of this hev serology in the diagnostic work flow to detect viral causes of recent hepatitis. | 2017 | 28285979 |
| epstein-barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle. | the epstein-barr virus (ebv) nuclear antigen 1 (ebna1) is a sequence-specific dna-binding protein that plays an essential role in viral episome replication and segregation, by recruiting the cellular complex of dna replication onto the origin (orip) and by tethering the viral dna onto the mitotic chromosomes. whereas the mechanisms of viral dna replication are well documented, those involved in tethering ebna1 to the cellular chromatin are far from being understood. here, we have identified regu ... | 2017 | 28284242 |
| establishment of multiplex solid-phase strip pcr test for detection of 24 ocular infectious disease pathogens. | to establish and evaluate a new multiplex solid-phase strip polymerase chain reaction (strip pcr) for concurrent detection of common ocular infectious disease pathogens. | 2017 | 28282487 |
| the mediating role of meaning in the association between stress and health. | stress is a common feature of life and has routinely been linked with negative health outcomes. however, meaning has been identified as a possible buffer against stress. | 2017 | 28281134 |
| viral load of ebv dnaemia is a predictor of ebv-related post-transplant lymphoproliferative disorders in pediatric renal transplant recipients. | post-transplant lymphoproliferative disorder (ptld) is a severe complication of solid organ transplantation that can be classified into two major subtypes, namely, early lesions and non-early lesions, based on histopathological findings. in the vast majority of cases, proliferating cells are b lymphocytes and, most frequently, proliferation is induced by epstein-barr virus (ebv) infection. | 2017 | 28280938 |
| ebv-associated hepatic smooth muscle tumor of uncertain biologic behavior after heart transplantation in a pediatric patient: case report. | epstein-barr virus-associated smooth muscle tumor (ebv-smt) is a rare neoplasm recognized in immunocompromised patients. there are less than 30 cases of ebv-smt reported in pediatric population following solid organ transplantation. herein, we report a case of an 8-year-old female who was incidentally noted to have multiple lesions in the liver 8 years after heart transplantation. the tumor was composed of a cellular proliferation of spindle-shaped cells with low mitotic activity. the diagnosis ... | 2017 | 28280632 |
| epstein-barr virus-induced gene 3 (ebi3) can mediate il-6 trans-signaling. | ebi3 is a subunit of the composite cytokines il-27 and il-35. both have beneficial functions or effects in models of infectious and autoimmune diseases. this suggests that administration of ebi3 could be therapeutically useful by binding free p28 and p35 to generate il-27 and il-35. il-27- and il-35-independent functions of ebi3 could compromise its therapeutic uses. we therefore assessed the effects of ebi3 on cytokine receptor expressing cells. we observed that ebi3 activates stat3 and induces ... | 2017 | 28280243 |
| predictive biomarkers along gastric cancer pathogenetic pathways. | gastric cancer is the second leading cause of cancer all over the world. unfortunately, several gastric cancers are diagnosed in an advanced stage and chemotherapy and/or target therapies remain the only options to treat patients. areas covered: herein we evaluate the new molecular proposal of gastric cancer classification, offering the possibility to recognize different pathogenetic mechanisms and molecular biomarkers potentially useful for target therapies. expert commentary: the possibility o ... | 2017 | 28277834 |
| designing an effective vaccine to prevent epstein-barr virus-associated diseases: challenges and opportunities. | epstein-barr virus (ebv) is a ubiquitous herpesvirus associated with a number of clinical manifestations. primary ebv infection in young adolescents often manifests as acute infectious mononucleosis and latent infection is associated with multiple lymphoid and epithelial cancers and autoimmune disorders, particularly multiple sclerosis. areas covered: over the last decade, our understanding of pathogenesis and immune regulation of ebv-associated diseases has provided an important platform for th ... | 2017 | 28276306 |
| investigation on the association between thyroid tumorigeneses and herpesviruses. | herpesviruses have been associated with various human malignancies and with thyroid autoimmunity. aiming to investigate the presence of these viruses in thyroid nodules, we analyzed serum and thyroid tissue from 183 patients (83 benign and 100 malignant thyroid nodules). we also obtained 104 normal thyroid tissues extracted from the contralateral lobe of these patients. we used elisa to screen the serology of all patients and a real-time quantitative pcr to analyze thyroid tissue viral load in a ... | 2017 | 28276007 |
| gastric cancer genomics: advances and future directions. | advancement in the field of cancer genomics is revolutionizing the molecular characterization of a wide variety of different cancers. recent application of large-scale, next-generation sequencing technology to gastric cancer, which remains a major source of morbidity and mortality throughout the world, has helped better define the complex genomic landscape of this cancer. these studies also have led to the development of novel genomically based molecular classification systems for gastric cancer ... | 2017 | 28275688 |
| post-transplant lymphoproliferative disorder after liver transplantation: incidence, long-term survival and impact of serum tacrolimus level. | to investigate incidence and survival of post-transplant lymphoproliferative disorder (ptld) patients after liver transplantation. | 2017 | 28275302 |