Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| syntheses of potent teixobactin analogues against methicillin-resistant staphylococcus aureus (mrsa) through the replacement of l-allo-enduracididine with its isosteres. | the recently discovered cyclic depsipeptide, teixobactin, is a highly potent antibiotic against multi-drug resistant pathogens such as methicillin-resistant staphylococcus aureus (mrsa) and mycobaterium tuberculosis. it comprises of 4 d amino acids and a rare l-allo-enduracididine amino acid. the synthesis of a properly protected l-allo-enduracididine amino acid and its incorporation into teixobactin is time consuming, synthetically challenging and low yielding and is therefore a major bottlenec ... | 2017 | 28650495 |
| komodo dragon-inspired synthetic peptide drgn-1 promotes wound-healing of a mixed-biofilm infected wound. | cationic antimicrobial peptides are multifunctional molecules that have a high potential as therapeutic agents. we have identified a histone h1-derived peptide from the komodo dragon (varanus komodoensis), called vk25. using this peptide as inspiration, we designed a synthetic peptide called drgn-1. we evaluated the antimicrobial and anti-biofilm activity of both peptides against pseudomonas aeruginosa and staphylococcus aureus. drgn-1, more than vk25, exhibited potent antimicrobial and anti-bio ... | 2017 | 28649410 |
| ecological networking of cystic fibrosis lung infections. | in the context of a polymicrobial infection, treating a specific pathogen poses challenges because of unknown consequences on other members of the community. the presence of ecological interactions between microbes can change their physiology and response to treatment. for example, in the cystic fibrosis lung polymicrobial infection, antimicrobial susceptibility testing on clinical isolates is often not predictive of antibiotic efficacy. novel approaches are needed to identify the interrelations ... | 2016 | 28649398 |
| altered antibacterial activity of curcumin in the presence of serum albumin, plasma and whole blood. | antibacterial effect is one of the major therapeutic activities of plant-derived curcumin. this work evaluated the effect of serum albumin, human plasma, and whole blood on the in vitro activity of curcumin against eight clinical bacterial isolates by standard broth microdilution and plate-counting methods. toxicological effects of curcumin towards human red blood cells (rbcs) and peripheral blood mononuclear cells (pbmcs) were also investigated. curcumin exhibited weak activity against gram-neg ... | 2017 | 28649069 |
| antibacterial activity of penicillins alone and in combination with different agents against staphylococcus aureus. | difficulties in the treatment of the resistant strains of staphylococcus aureus, which is a frequent cause of nosocomial infections in paediatric patients, has prompted this research to empower the usage of various combinations of penicillin. during the study period 17,452 clinical samples were processed for culture. the positive cultures yielded 564 strains of s. aureus. out of these, 362 (64.2%) isolates were found to be methicillin sensitive s. aureus (mssa) and 202 (35.8%) methicillin resist ... | 2017 | 28649062 |
| optimization of hydrogel containing toluidine blue o for photodynamic therapy by response surface methodology. | photodynamic therapy with toluidine blue o (tbo) hydrogel exhibits antibacterial activity against staphylococcus aureus and escherichia coli in this paper. the response surface methodology is employed to optimize formulations for antibacterial activity. the optimal formulations are carbomer concentration of 3% (w/v), tbo concentration of 0.1mg/ml and the quality ratio of naoh and carbomer of 0.4 (w/w). under the optimized formulations, the log-transformed of cfuml(-1) on the staphylococcus aureu ... | 2017 | 28649006 |
| evaluation of vancomycin mic creep in methicillin-resistant staphylococcus aureus infections-a systematic review and meta-analysis. | vancomycin is currently the primary option treatment for methicillin-resistant staphylococcus aureus (mrsa). however, an increasing number of mrsa isolates with high mics, within the susceptible range (vancomycin mic creep), are being reported worldwide. resorting to a meta-analysis approach, this study aims to assess the evidence of vancomycin mic creep. | 2017 | 28648858 |
| the influence of mild acidity on lysyl-phosphatidylglycerol biosynthesis and lipid membrane physico-chemical properties in methicillin-resistant staphylococcus aureus. | the increased biosynthesis of lysyl-phosphatidylglycerol in staphylococcus aureus when cultured under conditions of mild acidity and the resultant increased proportion of this lipid in the plasma membrane of the bacterium, alters the physico-chemical properties of lipid bilayers in a manner which is itself dependent upon environmental ph. clinically relevant strains of s. aureus, both methicillin susceptible and resistant, all exhibited increased lysyl-phosphatidylglycerol biosynthesis in respon ... | 2017 | 28648851 |
| pulmonary delivery of synergistic combination of fluoroquinolone antibiotic complemented with proteolytic enzyme: a novel antimicrobial and antibiofilm strategy. | bacterial resistance remains a major hindrance in treatment with antimicrobial agents. therefore, we assessed the improved antimicrobial and antibiofilm activity of levofloxacin (lfx) and serratiopeptidase (srp) combinations in in vitro microbiological studies. further, pharmacodynamic and pharmacokinetic studies of liposomal lfx in combination with srp (lfx liposome-srp) were performed in s. aureus infected rats. lfx at sub-mic with srp eradicated >90% of the preformed biofilm. the entrapment e ... | 2017 | 28648640 |
| [effects of combined application of culture supernatant of human umbilical cord mesenchymal stem cells and ciprofloxacin on staphylococcus aureus in vitro]. | objective: to explore the effects of combined application of culture supernatant of human umbilical cord mesenchymal stem cells (hucmscs) and ciprofloxacin on staphylococcus aureus (sa) in vitro. methods: hucmscs were isolated from umbilical cord tissue of full-term healthy fetus after cesarean section and cultured. cells in the third passage were used in the experiments after identification. sa strains isolated from wounds of burn patients in our burn wards were used in the experiments. cells w ... | 2017 | 28648039 |
| a new model for biofilm formation and inflammatory tissue reaction: intraoperative infection of a cranial implant with staphylococcus aureus in rats. | implant failure is a severe and frequent adverse event in all areas of neurosurgery. it often involves infection with biofilm formation, accompanied by inflammation of surrounding tissue, including the brain, and bone loss. the most common bacteria involved are staphylococcus aureus. we here test whether intraoperative infection of intracranial screws with staphylococcus aureus would lead to biofilm formation and inflammatory tissue reaction in rats. | 2017 | 28647798 |
| antimicrobial investigation of selected soil actinomycetes isolated from unexplored regions of kashmir himalayas, india. | the aim of the present study was to isolate and evaluate the antimicrobial potential of soil actinomycetes of kashmir himalayas. the secondary metabolites of actinomycetes are the prominent source of antibiotics. a total of 121 morphologically different actinomycete strains were isolated and screened for antimicrobial activity against various human pathogens. the ethyl acetate extract of fermented broth an actinomycete strain, identified as streptomyces pratensis exhibited significant antimicrob ... | 2017 | 28647504 |
| self-disinfecting surfaces and activity against staphyloccocus aureus atcc 6538 under real-life conditions. | environmental surface contamination provides a potential reservoir for pathogens to cause infections. as such, self-disinfecting surfaces have been developed to possibly reduce exogenous transmission. five different self-disinfecting surfaces were evaluated for activity against staphylococcus aureus atcc 6538 under real-life conditions using the dry inoculation method. various antimicrobial effects were detected. however, following disinfection with alcoholic wipes, these effects disappeared. fu ... | 2017 | 28647424 |
| test characteristics of milk amyloid a elisa, somatic cell count, and bacteriological culture for detection of intramammary pathogens that cause subclinical mastitis. | bovine mastitis is an important disease in the dairy industry, causing economic losses as a result of withheld milk and treatment costs. several studies have suggested milk amyloid a (maa) as a promising biomarker in the diagnosis of mastitis. in the absence of a gold standard for diagnosis of subclinical mastitis, we estimated the diagnostic test accuracy of a commercial maa-elisa, somatic cell count (scc), and bacteriological culture using bayesian latent class modeling. we divided intramammar ... | 2017 | 28647334 |
| higher mortality of severe influenza patients with probable aspergillosis than those with and without other coinfections. | aspergillus-associated infection might comprise up to 23-29% of severe influenza patients from the community throughout stay in an intensive care unit (icu). in taiwan, cases of severe influenza with aspergillosis are increasingly reported. therefore, we describe the relative risk of mortality among severe influenza patients with aspergillosis and other coinfections compared to severe influenza patients without aspergillus coinfections. | 2017 | 28647219 |
| toxic shock syndrome - the seven rs of management and treatment. | staphylococcal and streptococcal toxic shock syndrome (tss) are associated with significant morbidity and mortality. there has been considerable progress in understanding the pathophysiology and delineating optimal management and treatment. this article reviews the management of tss, outlining the 'seven rs of managing and treating tss': recognition, resuscitation, removal of source of infection, rational choice of antibiotics, role of adjunctive treatment (clindamycin and intravenous immunoglob ... | 2017 | 28646955 |
| generalized herd effects and vaccine evaluation: impact of live influenza vaccine on off-target bacterial colonisation. | interactions between pathogens and commensal microbes are major contributors to health and disease. infectious diseases however are most often considered independent, viewed within a one-host one-pathogen paradigm and, by extension, the interventions used to treat and prevent them are measured and evaluated within this same paradigm. vaccines, especially live vaccines, by stimulating immune responses or directly interacting with other microbes can alter the environment in which they act, with ef ... | 2017 | 28646948 |
| microbiological purity assessment of cosmetics used by one and several persons and cosmetics after their expiry date | microbiological purity of cosmetics provides safety of users during their use, prevents physicochemical changes of a preparation, infections and diseases of the skin. | 2017 | 28646837 |
| eco-friendly synthesis of silver nanoparticles using green algae (caulerpa serrulata): reaction optimization, catalytic and antibacterial activities. | stable colloidal silver nanoparticles (agnps) were synthesized using caulerpa serrulata (green marine algae) aqueous extract as an efficient reducing and stabilizing agent. this method is considered to be a sustainable alternate to the more complicated chemical procedures. to achieve the optimization synthesis of agnps, several effects such as extract concentration, contact time, ph values, and temperature were examined. the synthesized agnps were characterized by uv-vis spectroscopy, ft-ir, xrd ... | 2017 | 28646435 |
| photodynamic therapy controls of staphylococcus aureus intradermal infection in mice. | infections caused by staphylococcus aureus lead to skin infections, as well as soft tissues and bone infections. given the communal resistance to antibiotics developed by strains of this bacterium, photodynamic therapy emerges as a promising alternative treatment to control and cure infections. females of the balb/c mice were infected with 10(8) cfu of methicillin-resistant s. aureus (mrsa) and divided into four distinct groups: p-l- (negative control group), p+l- (group exposed only to curcumin ... | 2017 | 28646389 |
| crispr/cas9-mediated genome editing via postnatal administration of aav vector cures haemophilia b mice. | haemophilia b, a congenital haemorrhagic disease caused by mutations in coagulation factor ix gene (f9), is considered an appropriate target for genome editing technology. here, we describe treatment strategies for haemophilia b mice using the clustered regularly interspaced short palindromic repeat (crispr)/cas9 system. administration of adeno-associated virus (aav) 8 vector harbouring staphylococcus aureus cas9 (sacas9) and single guide rna (sgrna) to wild-type adult mice induced a double-stra ... | 2017 | 28646206 |
| staphylococcus aureus strain newman photoinactivation and cellular response to sunlight exposure. | sunlight influences microbial water quality of surface waters. previous studies have investigated photoinactivation mechanisms and cellular photostress responses of fecal indicator bacteria (fib), including escherichia coli and enterococci, but further work is needed to characterize photostress responses of bacterial pathogens. here we investigate the photoinactivation of staphylococcus aureus (strain newman), a pigmented, waterborne pathogen of emerging concern. we measured photodecay using sta ... | 2017 | 28646114 |
| structures and dynamics of hibernating ribosomes from staphylococcus aureus mediated by intermolecular interactions of hpf. | in bacteria, ribosomal hibernation shuts down translation as a response to stress, through reversible binding of stress-induced proteins to ribosomes. this process typically involves the formation of 100s ribosome dimers. here, we present the structures of hibernating ribosomes from human pathogen staphylococcus aureus containing a long variant of the hibernation-promoting factor (sahpf) that we solved using cryo-electron microscopy. our reconstructions reveal that the n-terminal domain (ntd) of ... | 2017 | 28645916 |
| the first nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in japan. | to investigate the trends of antimicrobial resistance in pathogens isolated from skin and soft-tissue infections (ssti) at dermatology departments in japan, a japanese surveillance committee conducted the first nationwide survey in 2013. three main organisms were collected from ssti at 30 dermatology departments in medical centers and 10 dermatology clinics. a total of 860 strains - 579 of staphylococcus aureus, 240 of coagulase-negative staphylococci, and 41 of streptococcus pyogenes - were col ... | 2017 | 28645883 |
| the effect of antimicrobial photodynamic therapy on the expression of novel methicillin resistance markers determined using cdna-aflp approach in staphylococcus aureus. | widespread methicillin resistant staphylococcus aureus (mrsa) and absence of effective antimicrobial agents has led to limited therapeutic options for treating mrsa infection. we aimed to evaluate the effect of antimicrobial photodynamic therapy (apdt) on the expression of novel identified methicillin resistance markers (nimrms) in s. aureus using complementary dna-amplified fragment length polymorphism (cdna-aflp) approaches to address the therapeutic alternatives for mrsa infections. | 2017 | 28645784 |
| the scottish enhanced staphylococcus aureus bacteraemia surveillance programme: the first 18 months of data in children. | national enhanced surveillance of staphylococcus aureus bacteraemia (sab) commenced on 1(st) october 2014 to gain a more in-depth understanding of the epidemiology of sab in scotland. children under 16 years of age were analysed separately from adults because previous studies had demonstrated epidemiological differences. | 2017 | 28645466 |
| treatment results of corneal collagen cross-linking combined with riboflavin and 440 nm blue light for bacterial corneal ulcer in rabbits. | to study the treatment effect of corneal collagen cross-linking (cxl) combined with 440 nm blue light and riboflavin on bacterial corneal ulcer using animal experiments. | 2017 | 28644681 |
| antibacterial effect of a 4x cu-tio₂ coating simulating acute periprosthetic infection-an animal model. | the purpose of our study was to investigate the antibacterial effect of a spacer (ti6al4v) coated with 4x cu-tio₂ in an animal model simulating an acute periprosthetic infection by staphylococcus aureus. ti6al4 bolts contaminated with staphylococcus aureus were implanted into the femoral condyle of rabbits (n = 36) divided into 3 groups. after one week in group 1 (control) the bolts were removed without any replacement. in group2 ti6al4v bolts with a 4x cu-tio₂ coating and in group 3 beads of a ... | 2017 | 28644421 |
| enhanced antibacterial activity of ent-labdane derivatives of salvic acid (7α-hydroxy-8(17)-ent-labden-15-oic acid): effect of lipophilicity and the hydrogen bonding role in bacterial membrane interaction. | in the present study, the antibacterial activity of several ent-labdane derivatives of salvic acid (7α-hydroxy-8(17)-ent-labden-15-oic acid) was evaluated in vitro against the gram-negative bacterium escherichia coli and the gram-positive bacteria staphylococcus aureus and bacillus cereus. for all of the compounds, the antibacterial activity was expressed as the minimum inhibitory concentration (mic) in liquid media and minimum inhibitory amount (mia) in solid media. structure activity relations ... | 2017 | 28644410 |
| development of silver-nanoparticle-decorated emulsion-templated hierarchically porous poly(1-vinylimidazole) beads for water treatment. | water, the driver of nature, has always been polluted by the blind hurling of highly toxic contaminants, but human-friendly science has continuously been presenting better avenues to help solve these challenging issues. in this connection, the present study introduces novel nanocomposites composed of emulsion-templated hierarchically porous poly(1-vinylimidazole) beads loaded with the silver nanoparticles generated via an in situ approach. these nanocomposites have been thoroughly characterized ... | 2017 | 28644011 |
| nonribosomal peptide synthetase biosynthetic clusters of eskape pathogens. | covering: up to 2017.natural products are important secondary metabolites produced by bacterial and fungal species that play important roles in cellular growth and signaling, nutrient acquisition, intra- and interspecies communication, and virulence. a subset of natural products is produced by nonribosomal peptide synthetases (nrpss), a family of large, modular enzymes that function in an assembly line fashion. because of the pharmaceutical activity of many nrps products, much effort has gone in ... | 2017 | 28642945 |
| genome comparisons of two taiwanese community-associated methicillin-resistant staphylococcus aureus st59 clones support the multi-origin theory of ca-mrsa. | sequence type (st) 59 is an epidemic lineage of community-associated methicillin-resistant staphylococcus aureus (ca-mrsa) in asia. two st59 clones are prevalent in taiwan: the taiwan clone (tw) causes severe infections, whereas the asian-pacific clone (ap) is usually commensal. in this study, we sequenced the genome and transcriptome of the representative strains of these two clones and found their differences to focus on three mobile genetic elements: tw carries sccmec type vt, panton-valentin ... | 2017 | 28642157 |
| new and improved? a review of novel antibiotics for gram-positive bacteria. | the number of antibiotics in the pipeline targeting gram-positive pathogens has increased in recent years. | 2017 | 28642145 |
| chimeric analogs of human β-defensin 1 and θ-defensin disrupt pre-established bacterial biofilms. | antibiofilm activity of several human defensin analogs that have the ability to kill planktonic bacteria, against pre-established biofilms of escherichia coli mg1655 and staphylococcus aureus nctc 8530 were examined. linear and linear fatty acylated analogs did not show any activity while disulfide constrained analogs disrupted pre-established s. aureus biofilms. chimeric analogs of human β-defensin 1 and θ-defensin, hbtd-1 and [d]hbtd-1 were highly active against s. aureus biofilms. among the a ... | 2017 | 28642103 |
| transfer of antibiotic resistance in staphylococcus aureus. | staphylococcus aureus is a serious human pathogen with remarkable adaptive powers. antibiotic-resistant clones rapidly emerge mainly by acquisition of antibiotic-resistance genes from other s. aureus strains or even from other genera. transfer is mediated by a diverse complement of mobile genetic elements and occurs primarily by conjugation or bacteriophage transduction, with the latter traditionally being perceived as the primary route. recent work on conjugation and transduction suggests that ... | 2017 | 28641931 |
| the antimicrobial spectrum of xeroform(®). | xeroform(®) is a petrolatum-based fine mesh gauze containing 3% bismuth tribromophenate. bismuth, similar to other metals, has antimicrobial properties. xeroform(®) has been used for decades in burn and plastic surgery as a donor site dressing and as a covering for wounds or partial thickness burns. despite this, the antimicrobial spectrum of xeroform(®) remains largely unknown. we examined the in-vitro efficacy of xeroform(®) against common burn pathogens using zone-of-inhibition methodology in ... | 2017 | 28641915 |
| 1,1ꞌ-carbonyldiimidazole (cdi) mediated facile synthesis, structural characterization, antimicrobial activity and in-silico studies of coumarin-3-carboxamide derivatives. | despite of the availability of variety of antibacterial agents, re-emergance of pathogenic bacteria is still a serious medical concern. so, identification of new, safer, and selective antibacterial agents is the key interest in the medicinal chemistry research. | 2017 | 28641525 |
| pathogen-specific mortality in very low birth weight infants with primary bloodstream infection. | mortality in very low birth weight infants following microbiology confirmed primary bloodstream infections varies with the type of causative pathogen. given evidence from other studies that infections with gram negative bacteria and fungi cause a higher case fatality risk. we tried to confirm this in a nation-wide multi-center trial. | 2017 | 28640920 |
| mrsa infections in norway: a study of the temporal evolution, 2006-2015. | norway has one of the lowest prevalences of methicillin-resistant staphylococcus aureus (mrsa) infections in the world. this study exploits the extensive data on mrsa infections in the norwegian surveillance system to investigate the important factors defining the mrsa epidemiology. | 2017 | 28640901 |
| dominance of community-associated methicillin-resistant staphylococcus aureus clones in a maternity hospital. | methicillin- resistant staphylococcus aureus (mrsa) is a major pathogen causing healthcare- and community- acquired infections. the purpose of this study was to characterize mrsa isolated at the maternity hospital between 2006 and 2011 for their genetic relatedness. | 2017 | 28640870 |
| chemical composition and biological activities of leaf and fruit essential oils from eucalyptus camaldulensis. | the chemical composition of the essential oils from the leaves and fruit of eucalyptus camaldulensis grown in mersin, turkey was analyzed using gas chromatography (gc) and gas chromatography-mass spectrometry (gc-ms) techniques. the biological activities (antibacterial and antifungal) were examined using the agar well diffusion method. the main leaf oil constituents were p-cymene (42.1%), eucalyptol (1,8-cineole) (14.1%), α-pinene (12.7%) and α-terpinol (10.7%). the main constituents of the frui ... | 2017 | 28640755 |
| panton-valentine leukocidin producing staphylococcus aureus facial pyomyositis causing partial cavernous sinus thrombosis. | we present a case of sub-total cavernous sinus thrombosis secondary to panton-valentine leucocidin-associated staphylococcus aureus pyomyositis of the muscles of mastication in a previously healthy child, who was successfully managed with no residual disease. he was found to have a factor v leiden heterozygous mutation. we highlight the propensity of pvl-sa to induce venous thrombosis at any site, but with potential for more severe consequences in the head. we highlight pyomyositis as a differen ... | 2017 | 28640000 |
| agr functionality affects clinical outcomes in patients with persistent methicillin-resistant staphylococcus aureus bacteraemia. | methicillin-resistant staphylococcus aureus bacteremia (mrsab) often persists despite appropriate antibiotic therapy. it is unclear what microbiological factors contribute to poor clinical outcomes in persistent mrsab (pmrsab). we aimed to identify clinical and microbiological risk factors for in-hospital mortality in pmrsab. we analysed mrsab cases prospectively collected between 2009 and 2016 at 11 hospitals in korea, defining cases of pmrsab as mrsab lasting ≥5 days despite administration of ... | 2017 | 28639163 |
| bacterial genome sequencing in clinical microbiology: a pathogen-oriented review. | in recent years, whole-genome sequencing (wgs) has been perceived as a technology with the potential to revolutionise clinical microbiology. herein, we reviewed the literature on the use of wgs for the most commonly encountered pathogens in clinical microbiology laboratories: escherichia coli and other enterobacteriaceae, staphylococcus aureus and coagulase-negative staphylococci, streptococci and enterococci, mycobacteria and chlamydia trachomatis. for each pathogen group, we focused on five di ... | 2017 | 28639162 |
| phytochemical screening, antimicrobial and cytotoxicity studies of ethanol leaf extract of aphaniasenegalensis (sapindaceae). | aphania senegalensis (sapindaceae) is commonly used in senegalese traditional medicine to treat pain, inflammation, asthenia, bacterial and fungal infections. the aim of this study was to determine the type of phytochemical constituents present in the ethanol leaf extract and its antimicrobial activity against selected bacterial and fungal pathogens. | 2017 | 28638876 |
| cuff extrusion in peritoneal dialysis: single-centre experience with the cuff-shaving procedure in five patients over a 4-year period. | catheter-related infections in peritoneal dialysis (pd) remain a significant complication, and some patients with recurrent exit-site (esi) and/or tunnel infections may experience external cuff extrusion. in these cases, cuff-shaving has been described as a possible course of treatment. during a 4-year period, there were 44 patients with pd at our department; all received double-cuffed tenckhoff catheters. six (13%) never started on pd. five (13%) of the 38 active pd patients experienced cuff ex ... | 2017 | 28638613 |
| the anticancer peptide tat-rasgap317-326 exerts broad antimicrobial activity. | antibiotic resistance has become a major health issue. nosocomial infections and the prevalence of resistant pathogenic bacterial strains are rising steadily. therefore, there is an urgent need to develop new classes of antibiotics effective on multi-resistant nosocomial pathogenic bacteria. we have previously shown that a cell-permeable peptide derived from the p120 ras gtpase-activating protein (rasgap), called tat-rasgap317-326, induces cancer cell death, inhibits metastatic progression, and ... | 2017 | 28638371 |
| effect of maternal obesity on maternal-fetal transfer of preoperative cefazolin at cesarean section. | american congress of obstetricians and gynecologists recommends a single dose of antibiotic prophylaxis before all cesarean sections (c/s). this recommendation is based on pharmacokinetic studies that include only non-obese patients. we sought to evaluate 1) cefazolin plasma concentrations among obese and non-obese patients after administration of a 2-g cefazolin dose for prevention of surgical wound infections, and 2) whether cefazolin concentration in fetal circulation may be protective agains ... | 2017 | 28638306 |
| predictors of adverse outcomes in children with staphylococcus aureus bacteremia. | staphylococcus aureus bacteremia is a common infection, associated with significant morbidity and mortality in children. factors associated with adverse treatment outcomes are poorly understood in the pediatric population. | 2017 | 28638305 |
| septic embolic stroke resulting from staphylococcus lugdunensis endocarditis. | staphylococcus lugdunensis, a member of the coagulase-negative staphylococci (cons), has been recognized as a causal organism for infective endocarditis since the 1980s. although most cons have an insidious and chronic nature, they are involved in a variety of systemic infections. s lugdunensis infective endocarditis is a rare entity but is as catastrophic as staphylococcus aureus infective endocarditis and requires aggressive antibiotic therapy and, typically, valve replacement. s lugdunensis i ... | 2017 | 28638293 |
| inflammation-induced osteogenesis in a rabbit tibia model. | pathologic conditions associated with bone formation can serve as models to identify bone-promoting mediators. the inflammatory response to bacterial infections generally leads to osteolysis and impaired bone healing, but paradoxically, it can also have pro-osteogenic effects. as a potential model to investigate pro-osteogenic stimuli, this study characterizes the bone formation in an established rabbit tibia model of periprosthetic infection. our hypothesis was that the infection with staphyloc ... | 2017 | 28637383 |
| prevalence of extended-spectrum β-lactamase-producing enterobacteriaceae and methicillin-resistant staphylococcus aureus in pig farms in switzerland. | the presence of methicillin-resistant staphylococcus aureus (mrsa) in pig farms has been widely reported, and the emergence of extended-spectrum β-lactamase-producing enterobacteriaceae (esbl-e) has been documented in several countries. however, data for switzerland are very scarce. this study aimed to compare changes in the prevalence of mrsa in swiss pig farms between 2008 and 2015 and make the first ever estimates of the presence of esbl-e and carbapenemase producers in pigs and pig farm work ... | 2017 | 28636975 |
| role of positively charged residues on the polar and non-polar faces of amphipathic α-helical antimicrobial peptides on specificity and selectivity for gram-negative pathogens. | we have designed de novo and synthesized eight 26-residue all d-conformation amphipathic α-helical cationic antimicrobial peptides (amps), four with "specificity determinants" which provide specificity for prokaryotic cells over eukaryotic cells and four amps without specificity determinants. the eight amps contain six positively charged lys residues on the polar face in four different arrangements to understand the role of these residues have on antimicrobial activity against 14 acinetobacter b ... | 2017 | 28636788 |
| semisynthetic flavone-derived antimicrobials with therapeutic potential against methicillin-resistant staphylococcus aureus (mrsa). | a new series of semisynthetic flavone-based small molecules mimicking antimicrobial peptides has been designed from natural icaritin to combat drug-resistant gram-positive bacterial infections. compound 6 containing two arginine residues exhibited excellent antibacterial activity against gram-positive bacteria, including mrsa, and very low toxicity to mammalian cells, resulting in a high selectivity of more than 511, comparable to that of several membrane-active antibiotics in clinical trials. o ... | 2017 | 28636355 |
| virulence genes of s. aureus from dairy cow mastitis and contagiousness risk. | staphylococcus aureus (s. aureus) is a major agent of dairy cow intramammary infections: the different prevalences of mastitis reported might be related to a combination of s. aureus virulence factors beyond host factors. the present study considered 169 isolates from different italian dairy herds that were classified into four groups based on the prevalence of s. aureus infection at the first testing: low prevalence (lp), medium-low (mlp), medium-high (mhp) and high (hp). we aimed to correlate ... | 2017 | 28635647 |
| synthesis, evaluation and modeling of some triazolothienopyrimidinones as anti-inflammatory and antimicrobial agents. | new triazolotetrahydrobenzothienopyrimidinone derivatives were synthesized. | 2017 | 28635307 |
| imipenem/cilastatin : a reappraisal of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy. | imipenem is an antibacterial agent of the carbapenem class of β-lactams, with a very broad spectrum of activity that includes most gram-negative and gram-positive pathogens, aerobes and anaerobes, and with marked activity against species producing β-lactamases. it is coadministered with cilastatin, a renal dehydropeptidase inhibitor that prevents renal metabolism of imipenem. as initial monotherapy, imipenem/cilastatin provides effective and well-tolerated treatment of moderate to severe infecti ... | 1992 | 28634918 |
| telavancin: a novel semisynthetic lipoglycopeptide agent to counter the challenge of resistant gram-positive pathogens. | telavancin (td-6424), a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by theravance for overcoming resistant gram-positive bacterial infections, specifically methicillin-resistant staphylococcus aureus (mrsa). the us food and drug administration (usfda) had approved telavancin in 2009 for the treatment of complicated skin and skin structure infections (csssis) caused by gram-positive bacteria, including mrsa (s. aureus, streptococcus agalactiae, s ... | 2017 | 28634536 |
| effectiveness and safety of daptomycin in patients with infective endocarditis undergoing heart valve replacement: a subgroup analysis from real-world data. | european cubicin(®) outcomes registry and experience (eu-core) was a retrospective, non-interventional, multicenter registry that collected real-world clinical outcomes following daptomycin use for the treatment of gram-positive infections. eu-core data from patients with infective endocarditis (ie) who underwent heart valve replacement were analysed. | 2017 | 28634535 |
| whole blood profiling of bacillus calmette-guérin-induced trained innate immunity in infants identifies epidermal growth factor, il-6, platelet-derived growth factor-ab/bb, and natural killer cell activation. | vaccination of infants with bacillus calmette-guérin (bcg) activates both the innate and adaptive arms of the immune response. the antimycobacterial effects of these responses most likely account for the ability of bcg to protect against childhood forms of tuberculosis (tb). there is also evidence for a heterologous protective effect of bcg vaccination against tb-unrelated mortality in low birth weight infants. a possible mechanism of action of this effect, the induction of trained innate immuni ... | 2017 | 28634479 |
| coumarin-benzimidazole hybrids as a potent antimicrobial agent: synthesis and biological elevation. | molecular hybridization approach is an emerging tool in drug discovery for designing new pharmacophores with biological activity. a novel, new series of coumarin-benzimidazole hybrids were designed, synthesized and evaluated for their broad spectrum antimicrobial activity. among all the synthesized molecules, compound (e)-3-(2-1h-benzo[d]imidazol-1-yl)-1-((4-chlorobenzyl)oxy)imino)ethyl)-2h-chromen-2-one showed the most promising broad spectrum antibacterial activity against pseudomonas aerugino ... | 2017 | 28634338 |
| alternative evolutionary pathways for drug-resistant small colony variant mutants in staphylococcus aureus. | staphylococcus aureus is known to generate small colony variants (scvs) that are resistant to aminoglycoside antibiotics and can cause persistent and recurrent infections. the scv phenotype is unstable, and compensatory mutations lead to restored growth, usually with loss of resistance. however, the evolution of improved growth, by mechanisms that avoid loss of antibiotic resistance, is very poorly understood. by selection with serial passaging, we isolated and characterized different classes of ... | 2017 | 28634236 |
| variation in empiric coverage versus detection of methicillin-resistant staphylococcus aureus and pseudomonas aeruginosa in hospitalizations for community-onset pneumonia across 128 us veterans affairs medical centers. | objective to examine variation in antibiotic coverage and detection of resistant pathogens in community-onset pneumonia. design cross-sectional study. setting a total of 128 hospitals in the veterans affairs health system. participants hospitalizations with a principal diagnosis of pneumonia from 2009 through 2010. methods we examined proportions of hospitalizations with empiric antibiotic coverage for methicillin-resistant staphylococcus aureus (mrsa) and pseudomonas aeruginosa (paer) and with ... | 2017 | 28633678 |
| variation of alkaloid contents and antimicrobial activities of papaver rhoeas l. growing in turkey and northern cyprus. | papaver rhoeas l. (papaveraceae) corn poppy, widely distributed in turkey, is used to make a cough syrup for children, as a tea for disturbed sleep, for pain relief and as a sedative in folk medicine. | 2017 | 28633584 |
| immunotherapy targeting adenosine synthase a decreases severity of staphylococcus aureus infection in mouse model. | staphylococcusaureus is a severe pathogen found in the community and in hospitals. most notably, methicillin-resistant s. aureus (mrsa) is resistant to almost all antibiotics, which is a growing public health concern. the emergence of drug-resistant strains has prompted the search for alternative treatments such as immunotherapeutic approaches. previous research showed that s. aureus exploit the immunomodulatory attributes of adenosine to escape host immunity. in this study, we investigated aden ... | 2017 | 28633319 |
| value of surgery for infective endocarditis in dialysis patients. | to determine the value of surgery for infective endocarditis (ie) in patients on hemodialysis by comparing the nature and invasiveness of endocarditis in hemodialysis and nonhemodialysis patients and their hospital and long-term outcomes, and identifying risk factors for time-related mortality after surgery. | 2017 | 28633210 |
| disinfection efficiencies of sage and spearmint essential oils against planktonic and biofilm staphylococcus aureus cells in comparison with sodium hypochlorite. | staphylococcus aureus causes human infections and foodborne intoxications. this study explored the potential antibacterial actions of sage and spearmint essential oils (eos) against both its planktonic and biofilm cells, in comparison with sodium hypochlorite (naocl), a commonly applied chemical sanitizer. initially, the minimum inhibitory and bactericidal concentrations (mics, mbcs) of each plant mixture were determined against planktonic cultures, following growth at 30°c for 24h. stationary p ... | 2017 | 28633052 |
| emerging biomarkers of illness severity: urinary metabolites associated with sepsis and necrotizing methicillin-resistant staphylococcus aureus pneumonia. | our objective was to illustrate the potential of metabolomics to identify novel biomarkers of illness severity in a child with fatal necrotizing pneumonia caused by methicillin-resistant staphylococcus aureus (mrsa). we present a case report with two control groups and a metabolomics analysis: an infant with fatal mrsa pneumonia, four children with influenza pneumonia (pneumonia control group), and seven healthy children with no known infections (healthy control group). urine samples were collec ... | 2017 | 28632946 |
| preferential aerosolization of bacteria in bioaerosols generated in vitro. | little is known about how bacteria are aerosolized in terms of whether some bacteria will be found in the air more readily than others that are present in the source. this report describes in vitro experiments to compare aerosolization rates (also known as preferential aerosolization) of gram-positive and gram-negative bacteria as well as rod- and coccus-shaped bacteria, using two nebulization conditions. | 2017 | 28632907 |
| [pyogenic liver abscess in children: clinical experience in a pediatric reference center]. | liver abscess is a serious and an uncommon pediatric disease. | 2017 | 28632826 |
| mait cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: defining a novel mechanism of superantigen-induced immunopathology and immunosuppression. | superantigens (sags) are potent exotoxins secreted by staphylococcus aureus and streptococcus pyogenes. they target a large fraction of t cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically encountered in toxic shock syndrome (tss). given the rapidity with which tss develops, designing timely and truly targeted therapies for this syndrome requires identification of key mediators of the cytokine storm's initial wave. equally important, ... | 2017 | 28632753 |
| infection of ventricular assist device detected and monitored by 18f-fdg pet/ct. | we report a case of a 59-year-old man who presented with fever, sepsis, and left cervicothoracic cutaneous inflammation 13 months after implantation of jarvik 2000 device. device infection was suspected and f-fdg pet/ct showed an intense and homogeneous uptake along driveline cable. bacteriological local sample showed staphylococcus aureus. after adapted antibiotherapy, control f-fdg pet/ct displays treatment efficacy with no residual uptake in driveline. f-fdg pet/ct could be an important tool ... | 2017 | 28632696 |
| what is behind the epidemiological difference between community-acquired and health-care associated methicillin-resistant staphylococcus aureus? | 2017 | 28632426 | |
| citrobacter freundii as a cause of acute suppurative thyroiditis in an immunocompetent adult female. | acute suppurative thyroiditis (ast) is an uncommon condition, in the patients with preexisting thyroid disease or immunosuppression. the most common cause of ast is bacterial, and the most common bacteria are staphylococcus aureus, staphylococcus epidermidis, escherichia coli, and klebsiella species. due to various complications such as septicemia, septic thrombophlebitis, necrotizing mediastinitis, or pericarditis, prompt diagnosis and treatment are the keys to reduce mortality and morbidity. h ... | 2017 | 28631657 |
| risk of cardiac pacemaker pocket infection in a tertiary care hospital. | the risk of pacemaker pocket infections (ppis) is rare with good antisepsis techniques and use of advanced antibiotics. however, injudicious antibiotic usage leads to the rise of multidrug-resistant bacteria, which may cause ppi. few reports exist about the microbial spectrum of the ppi from our country, prompting us to study the same. | 2017 | 28631632 |
| into the storm: chasing the opportunistic pathogen staphylococcus aureus from skin colonisation to life-threatening infections. | colonisation of the human skin by staphylococcus aureus is a precursor for a variety of infections ranging from boils to sepsis and pneumonia. the rapid emergence of methicillin-resistant s. aureus following the clinical introduction of this antimicrobial drug and reports of resistance to all currently used anti-staphylococcal drugs has added to its formidable reputation. s. aureus survival on the skin and in vivo virulence is underpinned by a remarkable environmental adaptability, made possible ... | 2017 | 28631399 |
| the mobile dso-gene-sso element in rolling-circle plasmids of staphylococci reflects the evolutionary history of its resistance gene. | the qacc and lnua genes of staphylococcus species were recently proposed to comprise a mobile element when residing on rolling-circle plasmids. here we present other examples of resistance genes on staphylococcal rolling-circle plasmids, including fosb producing resistance to fosfomycin, cat resulting in resistance to chloramphenicol and cadb for resistance to the toxic heavy metal cadmium. for three of these genes (qacc, lnua and fosb), evidence was obtained that the genes have spread between d ... | 2017 | 28631335 |
| prevalence of antimicrobial resistant pathogens from blood cultures: results from a laboratory based nationwide surveillance in ghana. | blood stream infections (bsi) are critical medical conditions with high morbidity and mortality. there is paucity of information on bsi from surveillance studies in ghana. | 2017 | 28630688 |
| looking to nature for a new concept in antimicrobial treatments: isoflavonoids from cytisus striatus as antibiotic adjuvants against mrsa. | the spread of multidrug-resistant staphylococcus aureus strains, including methicillin-resistant s. aureus (mrsa), has shortened the useful life of anti-staphylococcal drugs enormously. two approaches can be followed to address this problem: screening various sources for new leads for antibiotics or finding ways to disable the resistance mechanisms to existing antibiotics. plants are resistant to most microorganisms, but despite extensive efforts to identify metabolites that are responsible for ... | 2017 | 28630440 |
| multipathogenic necrotising supraglottitis in an immunocompetent patient. | supraglottitis is a potentially life-threatening condition. it is now uncommon due to the haemophilus influenzae type b vaccination and is more recently caused by streptococcus pneumoniae, s. pyogenes, h. influenzae non-type b, h. parainfluenzae, staphylococcus aureus and pasteurella multocida very rarely, it can cause necrotising supraglottitis/epiglottitis, and this has been reported in immunocompromised individuals. we present a unique case of multipathogenic supraglottitis causing laryngeal ... | 2017 | 28630241 |
| antimicrobial susceptibility trends among staphylococcus aureus isolates from u.s. hospitals: results from 7 years of the ceftaroline (aware) surveillance program, 2010 to 2016. | we evaluated trends in staphylococcus aureus antimicrobial susceptibility in u.s. hospitals in the 2010-2016 period. a total of 21,056 clinical isolates from 42 medical centers were tested for susceptibility by broth microdilution methods. methicillin-resistant s. aureus (mrsa) rates decreased from 50.0% (in 2010) to 42.2% (in 2016). susceptibility to erythromycin, levofloxacin, and clindamycin increased slightly, whereas susceptibility to ceftaroline, trimethoprim-sulfamethoxazole, and tetracyc ... | 2017 | 28630196 |
| topical antimicrobial treatments can elicit shifts to resident skin bacterial communities and reduce colonization by staphylococcus aureus competitors. | the skin microbiome is a complex ecosystem with important implications for cutaneous health and disease. topical antibiotics and antiseptics are often employed to preserve the balance of this population and inhibit colonization by more pathogenic bacteria. however, despite their widespread use, the impact of these interventions on broader microbial communities remains poorly understood. here, we report the longitudinal effects of topical antibiotics and antiseptics on skin bacterial communities ... | 2017 | 28630195 |
| β-lactam antibiotics with a high affinity for pbp2 act synergistically with the ftsz-targeting agent txa707 against methicillin-resistant staphylococcus aureus. | methicillin-resistant staphylococcus aureus (mrsa) is a multidrug-resistant pathogen that poses a significant risk to global health today. we have developed a promising new ftsz-targeting agent (txa707) with potent activity against mrsa isolates resistant to current standard-of-care antibiotics. we present here results that demonstrate differing extents of synergy between txa707 and a broad range of β-lactam antibiotics (including six cephalosporins, two penicillins, and two carbapenems) against ... | 2017 | 28630190 |
| in vitro activity of delafloxacin and microbiological response against fluoroquinolone-susceptible and nonsusceptible staphylococcus aureus isolates from two phase 3 studies of acute bacterial skin and skin structure infections. | delafloxacin is an investigational anionic fluoroquinolone antibiotic with broad-spectrum in vitro activity, including activity against gram-positive organisms, gram-negative organisms, atypical organisms, and anaerobes. the in vitro activity of delafloxacin and the percent microbiological response in subjects infected with fluoroquinolone-susceptible and nonsusceptible staphylococcus aureus isolates were determined from two global phase 3 studies of delafloxacin versus vancomycin plus aztreonam ... | 2017 | 28630189 |
| identification of 1-((2,4-dichlorophenethyl)amino)-3-phenoxypropan-2-ol, a novel antibacterial compound active against persisters of pseudomonas aeruginosa. | antibiotics typically fail to completely eradicate a bacterial population, leaving a small fraction of transiently antibiotic-tolerant persister cells intact. persisters are therefore seen to be a major cause of treatment failure and greatly contribute to the recalcitrant nature of chronic infections. the current study focused on pseudomonas aeruginosa, a gram-negative pathogen belonging to the notorious eskape group of pathogens (enterococcus faecium, staphylococcus aureus, klebsiella pneumonia ... | 2017 | 28630188 |
| antibiotic resistance as a stress response: recovery of high-level oxacillin resistance in methicillin-resistant staphylococcus aureus "auxiliary" (fem) mutants by induction of the stringent stress response. | studies with methicillin-resistant staphylococcus aureus (mrsa) strain col have shown that the optimal resistance phenotype requires not only meca but also a large number of "auxiliary genes" identified by tn551 mutagenesis. the majority of auxiliary mutants showed greatly increased levels of oxacillin resistance when grown in the presence of sub-mics of mupirocin, suggesting that the mechanism of reduced resistance in the auxiliary mutants involved the interruption of a stringent stress respons ... | 2017 | 28630179 |
| albumin inhibits pseudomonas aeruginosa quorum sensing and alters polymicrobial interactions. | polymicrobial interactions are complex and can influence the course of an infection, as is the case when two or more species exhibit a synergism that produces a disease state not seen with any of the individual species alone. cell-to-cell signaling is key to many of these interactions, but little is understood about how the host environment influences polymicrobial interactions or signaling between bacteria. chronic wounds are typically polymicrobial, with staphylococcus aureus and pseudomonas a ... | 2017 | 28630071 |
| effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and clostridium difficile infection: a systematic review and meta-analysis. | antibiotic stewardship programmes have been shown to reduce antibiotic use and hospital costs. we aimed to evaluate evidence of the effect of antibiotic stewardship on the incidence of infections and colonisation with antibiotic-resistant bacteria. | 2017 | 28629876 |
| nasal colonization of staphylococcus aureus colonal complex 5: prevalence, influencing factors, and phenotypic and molecular characteristics in pregnant chinese women. | colonal complex 5 (cc5) has been referred to as the most pandemic community-associated staphylococcus aureus in most asian countries. however, few studies have focused on cc5 isolates in pregnant women. the aim of this study was to determine the prevalence and phenotypic and molecular characteristics of s aureus and methicillin-resistant s aureus (mrsa) cc5 nasal colonization in pregnant chinese women. | 2017 | 28629756 |
| active identification of patients who are methicillin-resistant staphylococcus aureus colonized is not associated with longer duration of vancomycin therapy. | excessive prescribing of vancomycin among patients admitted to inpatient wards is a challenge for antimicrobial stewardship programs, especially in the setting of expanded screening programs for methicillin-resistant staphylococcus aureus (mrsa). studies examining factors associated with longer duration of vancomycin use are limited. | 2017 | 28629753 |
| atp-synthesis capacity of pulsed light-exposed bacteria. | the ability of four different bacteria to synthesize new atp upon exposure to different doses of pulsed-light (pl) irradiation was investigated. the bacterial cells were pl treated on a gel surface, resuspended in phosphate buffered saline (pbs) and subsequently incubated in tryptic soy broth (tsb) at 37°c. cellular atp levels were monitored during a 2h incubation period and compared to the respective colony count data. although pl affected atp production in a dose dependent manner, the results ... | 2017 | 28629639 |
| antibacterial activity of crude extracts of some south african medicinal plants against multidrug resistant etiological agents of diarrhoea. | this study evaluated the antibacterial activity of some plants used in folklore medicine to treat diarrhoea in the eastern cape province, south africa. | 2017 | 28629407 |
| a new antibiotic produced by the cyanobacterium-symbiotic fungus simplicillium lanosoniveum. | the culture broth of the cyanobacterium-symbiotic fungus simplicillium lanosoniveum var. tianjinienss q. l. dong exhibited unanticipated antibacterial activities against the gram-positive bacteria, particularly the pathogenic bacterium staphylococcus aureus, indicating the secretion of antibiotic-like metabolite, for which the modified sabouraud medium was the suitable medium. the antibiotic-like metabolite was separated with macroporous resins ct-12 (absorption) and 95% ethanol (desorption), pu ... | 2017 | 28629233 |
| assembly of chitosan support matrix with gallic acid-functionalized nanoparticles. | the incorporation of gallic acid (ga) in a direct way or into nanoparticles included in chitosan edible films appears as a suitable approach to increase its preservation upon adverse conditions. the addition of nanoparticles to chitosan-based matrices resulted in improvements in their solubility, swelling, and mechanical properties. it is worth noting that by means of the nanoencapsulation, the release process can be modulated in relation to the delivery of ga included directly in the matrix, re ... | 2017 | 28629089 |
| construction of poly(lactic-co-glycolic acid)/zno nanorods/ag nanoparticles hybrid coating on ti implants for enhanced antibacterial activity and biocompatibility. | poly(lactic-co-glycolic acid)/ag/zno nanorods coating were successfully prepared on the surface of ti metallic implants using a hydrothermal method and subsequent spin-coating of mixtures of poly(lactic-co-glycolic acid) and silver nanoparticles. the poly(lactic-co-glycolic acid)/ag/zno nanorods coating exhibited excellent antibacterial efficacy of over 96% against both staphylococcus aureus and escherichia coli when the initial content of ag nanoparticles was over 3wt%. in addition, the release ... | 2017 | 28629062 |
| unsuccessful treatment of methicillin-resistant staphylococcus aureus endocarditis with dalbavancin. | limited evidence describes dalbavancin use in infective endocarditis (ie). | 2017 | 28628223 |
| multidrug-resistant bacteria and travel. | antimicrobial resistance is a global problem which affects also tropical countries. travelers to these regions expose themselves to the risk of being colonised and infected with multidrug-resistant bacteria. the region visited, the occurrence of diarrhoea and the use of antibiotics are the principal risk factors leading to colonisation with multidrug-resistant enterobacteriaceae, which can affect up to 80% of travellers. colonisation with meticillin resistant staphylococcus aureus and vancomycin ... | 2017 | 28627852 |
| corneal ring infiltrate secondary to staphylococcus aureus-induced endogenous endophthalmitis: a case report. | 2017 | 28627769 | |
| the effects of selected phytochemicals on biofilm formed by five methicillin-resistant staphylococcus aureus. | the aim of this study was to evaluate the ability of 0.1% thyme oil (to), trans-cinnamaldehyde (tc), ferulic acid (fa), p-coumaric acid (p-ca), caffeic acid (ca), lavender essential oil (lo), geranium essential oil (go) and tee tree oil (tto) to control biofilms formed by methicillin-resistant staphylococcus aureus (mrsa) strains. depending on the strains, to reduced 59.7-85% of biofilm mass, while tc 52.9-82.4% after 48 h of treatment. reduction of metabolic activity of biofilms in ranges 79.3- ... | 2017 | 28627304 |
| derivatives of holomycin and cyclopropaneacetic acid from streptomyces sp. dt-a37. | on the basis of the one strain-many compounds strategy, five compounds including two new holomycin derivatives 2 - 3, two new cyclopropaneacetic acid derivatives 4 - 5, together with one known compound holomycin (1) were isolated from a marine-derived bacterium streptomyces sp. dt-a37. their structures were elucidated using nmr and hr-esi-ms analyses. all these compounds were evaluated for their antimicrobial activity, cytotoxic activity, and inhibitory activity against brd4 protein. compound 1 ... | 2017 | 28627048 |